Refine
Document Type
- Article (4)
Language
- English (4)
Has Fulltext
- yes (4)
Is part of the Bibliography
- no (4)
Keywords
- reproducibility (4) (remove)
Institute
- Medizin (2)
- Georg-Speyer-Haus (1)
- Psychologie (1)
Despite advances in bioinformatics, custom scripts remain a source of difficulty, slowing workflow development and hampering reproducibility. Here, we introduce Vectools, a command-line tool-suite to reduce reliance on custom scripts and improve reproducibility by offering a wide range of common easy-to-use functions for table and vector manipulation. Vectools also offers a number of vector related functions to speed up workflow development, such as simple machine learning and common statistics functions.
Despite advances in bioinformatics, custom scripts remain a source of difficulty, slowing workflow development and hampering reproducibility. Here, we introduce Vectools, a command-line tool-suite to reduce reliance on custom scripts and improve reproducibility by offering a wide range of common easy-to-use functions for table and vector manipulation. Vectools also offers a number of vector related functions to speed up workflow development, such as simple machine learning and common statistics functions.
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
Problematisation: In recent years, psychology has been going through a crisis of sorts. Research methods and practices have come under increased scrutiny, with many issues identified as negatively contributing to low replicability and reproducibility of psychological research.
Implications: As a consequence, researchers are increasingly called upon to overhaul and improve their research process. Various stakeholders within the scientific community are arguing for more openness and rigor within industrial and organisational (I-O) psychological research. A lack of transparency and openness further fuels criticisms as to the credibility and trustworthiness of I-O psychology which negatively affects the evidence-based practices which it supports. Furthermore, traditional gate-keepers such as grant agencies, professional societies and journals, are adapting their policies, reflecting an effort to curtail these trends.
Purpose: The purpose of this opinion paper is, therefore, to stimulate an open dialogue with the South African Journal of Industrial Psychology (SAJIP) contributing authors, its editorial board and readership about the challenges associated with the replication crisis in psychology. Furthermore, it attempts to discuss how the identified issues affect I-O psychology and how these could be managed through open science practices and other structural improvements within the SAJIP.
Recommendations: We enumerate several easily implementable open science practices, methodological improvements and editorial policy enhancements to enhance credibility and transparency within the SAJIP. Relying on these, we recommend changes to the current practices that can be taken up by researchers and the SAJIP to improve reproducibility and replicability in I-O psychological science.