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Scheidt, Moritz von ; Bauer, Sabine ; Ma, Angela ; Hao, Ke ; Kessler, Thorsten ; Vilne, Baiba ; Wang, Ying ; Hodonsky, Chani J. ; Ghosh, Saikat K.B. ; Mokry, Michal ; Gao, Hua ; Kawai, Kenji ; Sakamoto, Atsushi ; Kaiser, Juliane ; Bongiovanni, Dario ; Fleig, Julia ; Oldenbuettel, Lilith ; Chen, Zhifen ; Moggio, Aldo ; Sager, Hendrik ; Hecker, Judith S. ; Bassermann, Florian ; Mägdefessel, Lars ; Miller, Clint L. ; Koenig, Wolfgang ; Zeiher, Andreas M. ; Dimmeler, Stefanie ; Graw, Matthias ; Braun, Christian ; Ruusalepp, Arno ; Leeper, Nicholas J. ; Kovacic, Jason C. ; Björkegren, Johan L.M. ; Schunkert, Heribert
Background: Leukocyte progenitors derived from clonal hematopoiesis of undetermined potential (CHIP) are associated with increased cardiovascular events. However, the prevalence and functional relevance of CHIP in coronary artery disease (CAD) are unclear, and cells affected by CHIP have not been detected in human atherosclerotic plaques.
Methods: CHIP mutations in blood and tissues were identified by targeted deep-DNA-sequencing (DNAseq: coverage >3,000) and whole-genome-sequencing (WGS: coverage >35). CHIP-mutated leukocytes were visualized in human atherosclerotic plaques by mutaFISHTM. Functional relevance of CHIP mutations was studied by RNAseq.
Results: DNAseq of whole blood from 540 deceased CAD patients of the Munich cardIovaScular StudIes biObaNk (MISSION) identified 253 (46.9%) CHIP mutation carriers (mean age 78.3 years). DNAseq on myocardium, atherosclerotic coronary and carotid arteries detected identical CHIP mutations in 18 out of 25 mutation carriers in tissue DNA. MutaFISHTM visualized individual macrophages carrying DNMT3A CHIP mutations in human atherosclerotic plaques. Studying monocyte-derived macrophages from Stockholm-Tartu Atherosclerosis Reverse Networks Engineering Task (STARNET; n=941) by WGS revealed CHIP mutations in 14.2% (mean age 67.1 years). RNAseq of these macrophages revealed that expression patterns in CHIP mutation carriers differed substantially from those of non-carriers. Moreover, patterns were different depending on the underlying mutations, e.g. those carrying TET2 mutations predominantly displayed upregulated inflammatory signaling whereas ASXL1 mutations showed stronger effects on metabolic pathways.
Conclusions: Deep-DNA-sequencing reveals a high prevalence of CHIP mutations in whole blood of CAD patients. CHIP-affected leukocytes invade plaques in human coronary arteries. RNAseq data obtained from macrophages of CHIP-affected patients suggest that pro-atherosclerotic signaling differs depending on the underlying mutations. Further studies are necessary to understand whether specific pathways affected by CHIP mutations may be targeted for personalized treatment.
Koppers-Lalic, Danijela ; Verweij, Marieke C. ; Lipinska, Andrea D. ; Wang, Ying ; Quinten, Edwin ; Reits, Eric A. ; Koch, Joachim ; Loch, Sandra ; Marcondes Rezende, Marisa ; Daus, Franz ; Bienkowska-Szewczyk, Krystyna ; Osterrieder, Nikolaus ; Mettenleiter, Thomas C. ; Heemskerk, Mirjam H. M. ; Tampé, Robert ; Neefjes, Jacques J. ; Chowdhury, Shafiqul I. ; Ressing, Maaike E. ; Rijsewijk, Frans A. M. ; Wiertz, Emmanuel J. H. J.
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell. The transporter associated with antigen processing (TAP) plays an essential role in MHC class I–restricted antigen presentation, as TAP imports peptides into the ER, where peptide loading of MHC class I molecules takes place. In this study, the UL49.5 proteins of the varicelloviruses bovine herpesvirus 1 (BHV-1), pseudorabies virus (PRV), and equine herpesvirus 1 and 4 (EHV-1 and EHV-4) are characterized as members of a novel class of viral immune evasion proteins. These UL49.5 proteins interfere with MHC class I antigen presentation by blocking the supply of antigenic peptides through inhibition of TAP. BHV-1, PRV, and EHV-1 recombinant viruses lacking UL49.5 no longer interfere with peptide transport. Combined with the observation that the individually expressed UL49.5 proteins block TAP as well, these data indicate that UL49.5 is the viral factor that is both necessary and sufficient to abolish TAP function during productive infection by these viruses. The mechanisms through which the UL49.5 proteins of BHV-1, PRV, EHV-1, and EHV-4 block TAP exhibit surprising diversity. BHV-1 UL49.5 targets TAP for proteasomal degradation, whereas EHV-1 and EHV-4 UL49.5 interfere with the binding of ATP to TAP. In contrast, TAP stability and ATP recruitment are not affected by PRV UL49.5, although it has the capacity to arrest the peptide transporter in a translocation-incompetent state, a property shared with the BHV-1 and EHV-1 UL49.5. Taken together, these results classify the UL49.5 gene products of BHV-1, PRV, EHV-1, and EHV-4 as members of a novel family of viral immune evasion proteins, inhibiting TAP through a variety of mechanisms.
Altınçekiç, Nadide ; Korn, Sophie Marianne ; Qureshi, Nusrat Shahin ; Dujardin, Marie ; Ninot-Pedrosa, Martí ; Abele, Rupert ; Abi Saad, Marie Jose ; Alfano, Caterina ; Almeida, Fabio C. L. ; Alshamleh, Islam ; Amorim, Gisele Cardoso de ; Anderson, Thomas K. ; Anobom, Cristiane D. ; Anorma, Chelsea ; Bains, Jasleen Kaur ; Bax, Adriaan ; Blackledge, Martin ; Blechar, Julius ; Böckmann, Anja ; Brigandat, Louis ; Bula, Anna ; Bütikofer, Matthias ; Camacho-Zarco, Aldo R. ; Carlomagno, Teresa ; Caruso, Icaro Putinhon ; Ceylan, Betül ; Chaikuad, Apirat ; Chu, Feixia ; Cole, Laura ; Crosby, Marquise G. ; De Jesus, Vanessa ; Dhamotharan, Karthikeyan ; Felli, Isabella C. ; Ferner, Jan ; Fleischmann, Yanick ; Fogeron, Marie-Laure ; Fourkiotis, Nikolaos K. ; Fuks, Christin ; Fürtig, Boris ; Gallo, Angelo ; Gande, Santosh L. ; Gerez, Juan Atilio ; Ghosh, Dhiman ; Gomes-Neto, Francisco ; Gorbatyuk, Oksana ; Guseva, Serafima ; Hacker, Carolin ; Häfner, Sabine ; Hao, Bing ; Hargittay, Bruno ; Henzler-Wildman, Katherine ; Hoch, Jeffrey C. ; Hohmann, Katharina Felicitas ; Hutchison, Marie T. ; Jaudzems, Kristaps ; Jović, Katarina ; Kaderli, Janina ; Kalnins, Gints ; Kanepe, Iveta ; Kirchdoerfer, Robert N. ; Kirkpatrick, John ; Knapp, Stefan ; Krishnathas, Robin ; Kutz, Felicitas ; Zur Lage, Susanne ; Lambertz, Roderick ; Lang, Andras ; Laurents, Douglas ; Lecoq, Lauriane ; Linhard, Verena ; Löhr, Frank ; Malki, Anas ; Bessa, Luiza Mamigonian ; Martin, Rachel W. ; Matzel, Tobias ; Maurin, Damien ; McNutt, Seth W. ; Mebus-Antunes, Nathane Cunha ; Meier, Beat H. ; Meiser, Nathalie ; Mompeán, Miguel ; Monaca, Elisa ; Montserret, Roland ; Perez, Laura Mariño ; Moser, Celine ; Muhle-Goll, Claudia ; Neves-Martins, Thais Cristtina ; Ni, Xiamonin ; Norton-Baker, Brenna ; Pierattelli, Roberta ; Pontoriero, Letizia ; Pustovalova, Yulia ; Ohlenschläger, Oliver ; Orts, Julien ; Poian, Andrea T. da ; Pyper, Dennis Joshua ; Richter, Christian ; Riek, Roland ; Rienstra, Chad M. ; Robertson, Angus ; Pinheiro, Anderson S. ; Sabbatella, Raffaele ; Salvi, Nicola ; Saxena, Krishna ; Schulte, Linda ; Schiavina, Marco ; Schwalbe, Harald ; Silber, Mara ; Almeida, Marcius da Silva ; Sprague-Piercy, Marc A. ; Spyroulias, Georgios A. ; Sreeramulu, Sridhar ; Tants, Jan-Niklas ; Tars, Kaspars ; Torres, Felix ; Töws, Sabrina ; Trevino, Miguel A. ; Trucks, Sven ; Tsika, Aikaterini C. ; Varga, Krisztina ; Wang, Ying ; Weber, Marco E. ; Weigand, Julia E. ; Wiedemann, Christoph ; Wirmer-Bartoschek, Julia ; Wirtz Martin, Maria Alexandra ; Zehnder, Johannes ; Hengesbach, Martin ; Schlundt, Andreas
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium seeks to provide such new approaches by gathering scientific expertise worldwide. In particular, making available viral proteins and RNAs will pave the way to understanding the SARS-CoV-2 molecular components in detail. The research in COVID19-NMR and the resources provided through the consortium are fully disclosed to accelerate access and exploitation. NMR investigations of the viral molecular components are designated to provide the essential basis for further work, including macromolecular interaction studies and high-throughput drug screening. Here, we present the extensive catalog of a holistic SARS-CoV-2 protein preparation approach based on the consortium’s collective efforts. We provide protocols for the large-scale production of more than 80% of all SARS-CoV-2 proteins or essential parts of them. Several of the proteins were produced in more than one laboratory, demonstrating the high interoperability between NMR groups worldwide. For the majority of proteins, we can produce isotope-labeled samples of HSQC-grade. Together with several NMR chemical shift assignments made publicly available on covid19-nmr.com, we here provide highly valuable resources for the production of SARS-CoV-2 proteins in isotope-labeled form.
Ablikim, Medina ; Achasov, Mikhail N. ; Adlarson, Patrik ; Albrecht, Malte ; Aliberti, Riccardo ; Amoroso, Antonio ; An, M. R. ; An, Qi ; Bai, X. H. ; Bai, Yu ; Bakina, Olga ; Baldini Ferroli, Rinaldo ; Balossino, Ilaria ; Ban, Yong ; Batozskaya, V. ; Becker, D. ; Begzsuren, Khurelbaatar ; Berger, Niklaus ; Bertani, Monica ; Bettoni, Diego ; Bianchi, Fabrizio ; Bloms, Johannes ; Bortone, Alberto ; Boyko, Igor R. ; Briere, Roy A. ; Brüggemann, Anja ; Cai, Hao ; Cai, Xiao ; Calcaterra, Alessandro ; Cao, G. F. ; Cao, N. ; Çetin, Serkant Ali ; Chang, J. F. ; Chang, W. L. ; Chelkov, G. ; Chen, C. ; Chen, G. ; Chen, H. S. ; Chen, M. L. ; Chen, S. J. ; Chen, T. ; Chen, X. R. ; Chen, X. T. ; Chen, Y. B. ; Chen, Z. J. ; Cheng, W. S. ; Chu, X. ; Cibinetto, Gianluigi ; Cossio, Fabio ; Cui, J. J. ; Dai, H. L. ; Dai, J. P. ; Dbeyssi, A. ; de Boer, R. E. ; Dedovich, Dmitri V. ; Deng, Z. Y. ; Denig, Achim ; Denysenko, Igor ; Destefanis, Marco Giovanni Maria ; De Mori, Francesca ; Ding, Yanchun ; Dong, J. ; Dong, L. Y. ; Dong, M. Y. ; Dong, X. ; Du, S. X. ; Egorov, P. ; Fan, Y. L. ; Fang, J. ; Fang, S. S. ; Fang, W. X. ; Fang, Y. ; Farinelli, R. ; Fava, Luciano ; Feldbauer, Florian ; Felici, Giulietto ; Feng, C. Q. ; Feng, J. H. ; Fischer, K. ; Fritsch, Miriam ; Fritzsch, C. F. ; Fu, C. D. ; Gao, H. ; Gao, Y. N. ; Gao, Yang ; Garbolino, Sara ; Garzia, Isabella ; Ge, P. T. ; Geng, C. ; Gersabeck, Evelina ; Gilman, A. ; Götzen, Klaus ; Gong, L. ; Gong, W. X. ; Gradl, Wolfgang ; Greco, M. ; Gu, M. H. ; Guan, C. Y. ; Guo, A. Q. ; Guo, L. B. ; Guo, R. P. ; Guo, Y. P. ; Guskov, A. ; Han, T. T. ; Han, W. Y. ; Hao, X. Q. ; Harris, Frederick Allan ; He, K. K. ; He, K. L. ; Heinsius, Fritz-Herbert ; Heinz, C. H. ; Heng, Y. K. ; Herold, Christoph ; Himmelreich, Mathilde ; Holtmann, Tobias ; Hou, G. Y. ; Hou, Y. R. ; Hou, Z. L. ; Hu, H. M. ; Hu, J. F. ; Hu, T. ; Hu, Y. ; Huang, G. S. ; Huang, K. X. ; Huang, L. Q. ; Huang, L. Q. ; Huang, X. T. ; Huang, Y. P. ; Huang, Z. ; Hussain, Tahir ; Hüsken, Nils ; Imoehl, William ; Irshad, M. ; Jackson, J. ; Jaeger, S. ; Janchiv, S. ; Ji, Q. ; Ji, Q. P. ; Ji, X. B. ; Ji, X. L. ; Ji, Y. Y. ; Jia, Z. K. ; Jiang, H. B. ; Jiang, S. S. ; Jiang, X. S. ; Jiang, Y. ; Jiao, J. B. ; Jiao, Z. ; Jin, S. ; Jin, Y. ; Jing, M. Q. ; Johansson, Tord ; Kalantar-Nayestanaki, Nasser ; Kang, X. S. ; Kappert, R. ; Kavatsyuk, Myroslav O. ; Ke, B. C. ; Keshk, I. K. ; Khoukaz, Alfons ; Kiese, P. ; Kiuchi, R. ; Kliemt, Ralf ; Koch, L. ; Kolcu, O. B. ; Kopf, Bertram ; Kuemmel, M. ; Kuessner, M. ; Kupsc, Andrzej ; Kühn, Wolfgang ; Lane, J. J. ; Lange, Jens Sören ; Larin, Paul ; Lavania, A. ; Lavezzi, Lia ; Lei, Z. H. ; Leithoff, Hans Heinrich ; Lellmann, Max ; Lenz, T. ; Li, C. ; Li, C. ; Li, C. H. ; Li, Cheng ; Li, D. M. ; Li, F. ; Li, G. ; Li, H. ; Li, H. ; Li, H. B. ; Li, H. J. ; Li, H. N. ; Li, J. Q. ; Li, J. S. ; Li, J. W. ; Li, Ke ; Li, L. J. ; Li, L. K. ; Li, Lei ; Li, M. H. ; Li, P. R. ; Li, S. X. ; Li, S. Y. ; Li, T. ; Li, W. D. ; Li, W. G. ; Li, X. H. ; Li, Xing Long ; Li, Xiaoyu ; Li, Z. Y. ; Liang, H. ; Liang, H. ; Liang, H. ; Liang, Y. F. ; Liang, Y. T. ; Liao, G. R. ; Liao, L. Z. ; Libby, J. ; Limphirat, A. ; Lin, C. X. ; Lin, D. X. ; Lin, T. ; Liu, B. J. ; Liu, C. X. ; Liu, D. ; Liu, F. H. ; Liu, Fang ; Liu, Feng ; Liu, G. M. ; Liu, H. ; Liu, H. M. ; Liu, Huanhuan ; Liu, Huihui ; Liu, J. B. ; Liu, J. L. ; Liu, J. Y. ; Liu, K. ; Liu, K. Y. ; Liu, Ke ; Liu, L. ; Liu, M. H. ; Liu, P. L. ; Liu, Q. ; Liu, S. B. ; Liu, T. ; Liu, W. K. ; Liu, W. M. ; Liu, X. ; Liu, Y. ; Liu, Y. B. ; Liu, Z. A. ; Liu, Z. Q. ; Lou, X. C. ; Lu, F. X. ; Lu, H. J. ; Lu, J. G. ; Lu, X. L. ; Lu, Y. ; Lu, Y. P. ; Lu, Z. H. ; Luo, C. L. ; Luo, M. X. ; Luo, T. ; Luo, X. L. ; Lyu, X. R. ; Lyu, Y. F. ; Ma, F. C. ; Ma, H. L. ; Ma, L. L. ; Ma, M. M. ; Ma, Q. M. ; Ma, R. Q. ; Ma, R. T. ; Ma, X. Y. ; Ma, Y. ; Maas, Frank E. ; Maggiora, Marco ; Maldaner, Stephan ; Malde, S. ; Malik, Qadeer Afzal ; Mangoni, Alessio ; Mao, Y. J. ; Mao, Z. P. ; Marcello, S. ; Meng, Z. X. ; Messchendorp, Johannes Gerhardus ; Mezzadri, Giulio ; Miao, H. ; Min, T. J. ; Mitchell, Ryan Edward ; Mo, X. H. ; Muchnoi, Nikolai Yu. ; Muramatsu, Hajime ; Nefedov, Y. ; Nerling, Frank ; Nikolaev, Ivan Borisovich ; Ning, Z. ; Nisar, Shabana ; Niu, Y. ; Olsen, Stephen L. ; Ouyang, Q. ; Pacetti, Simone ; Pan, X. ; Pan, Y. ; Pathak, A. ; Pathak, A. ; Pelizäus, Marc ; Peng, H. P. ; Peters, Klaus ; Pettersson, J. ; Ping, J. L. ; Ping, R. G. ; Plura, S. ; Pogodin, S. ; Poling, Ronald ; Prasad, Vindhyawasini ; Qi, F. Z. ; Qi, H. ; Qi, H. R. ; Qi, M. ; Qi, T. Y. ; Qian, S. ; Qian, W. B. ; Qian, Z. ; Qiao, C. F. ; Qin, J. J. ; Qin, L. Q. ; Qin, X. P. ; Qin, X. S. ; Qin, Z. H. ; Qiu, J. F. ; Qu, S. Q. ; Qu, S. Q. ; Rashid, K. H. ; Redmer, C. F. ; Ren, K. J. ; Rivetti, Angelo ; Rodin, Viktor ; Da Rocha Rolo, Manuel Dionisio ; Rong, Gang ; Rosner, Christoph ; Ruan, S. N. ; Sang, H. S. ; Sarantsev, Andrei V. ; Schelhaas, Yasemin ; Schnier, Claudius ; Schoenning, Karin ; Scodeggio, Marco ; Shan, K. Y. ; Shan, W. ; Shan, X. Y. ; Shangguan, J. F. ; Shao, L. G. ; Shao, M. ; Shen, C. P. ; Shen, H. F. ; Shen, X. Y. ; Shi, B.-A. ; Shi, H. C. ; Shi, J. Y. ; Shi, R. S. ; Shi, X. ; D Shi, X. ; Song, J. J. ; Song, W. M. ; Song, Y. X. ; Sosio, Stefano ; Spataro, Stefano ; Stieler, F. ; Su, K. X. ; Su, P. P. ; Su, Y.-J. ; Sun, G. X. ; Sun, H. ; Sun, H. K. ; Sun, J. F. ; Sun, L. ; Sun, S. S. ; Sun, T. ; Sun, W. Y. ; Sun, X ; Sun, Y. J. ; Sun, Y. Z. ; Sun, Z. T. ; Tan, Y. H. ; Tan, Y. X. ; Tang, C. J. ; Tang, G. Y. ; Tang, J. ; Y Tao, L. ; Tao, Q. T. ; Teng, J. X. ; Thoren, Viktor ; Tian, W. H. ; Tian, Y. ; Uman, I. ; Wang, B. ; Wang, B. L. ; Wang, D. Y. ; Wang, F. ; Wang, H. J. ; Wang, H. P. ; Wang, K. ; Wang, L. L. ; Wang, M. ; Wang, M. Z. ; Wang, Meng ; Wang, S. ; Wang, T. ; Wang, T. J. ; Wang, W. ; Wang, W. H. ; Wang, W. P. ; Wang, X. ; Wang, X. F. ; Wang, X. L. ; Wang, Y. D. ; Wang, Y. F. ; Wang, Y. H. ; Wang, Y. Q. ; Wang, Ying ; Wang, Z. ; Wang, Z. Y. ; Wang, Ziyi ; Wei, D. H. ; Weidner, Frederik ; Wen, S. P. ; White, D. J. ; Wiedner, Ulrich ; Wilkinson, Guy ; Wolke, M. ; Wollenberg, Leonard ; Wu, J. F. ; Wu, L. H. ; Wu, L. J. ; Wu, X. ; Wu, X. H. ; Wu, Y. ; Wu, Z. ; Xia, L. ; Xiang, T. ; Xiao, D. ; Xiao, H. ; Xiao, S. Y. ; Xiao, Y. L. ; Xiao, Z. J. ; Xie, X. H. ; Xie, Y. ; Xie, Y. G. ; Xie, Y. H. ; Xie, Z. P. ; Xing, T. Y. ; Xu, C. F. ; Xu, C. J. ; Xu, G. F. ; Xu, Q. J. ; Xu, S. Y. ; Xu, X. P. ; Xu, Y. C. ; Yan, F. ; Yan, L. ; Yan, W. B. ; Yan, W. C. ; Yang, H. J. ; Yang, H. L. ; Yang, H. X. ; Yang, L. ; Yang, S. L. ; Yang, Tao ; Yang, Y. X. ; Yang, Yifan ; Ye, M. ; Ye, M. H. ; Yin, J. H. ; You, Z. Y. ; Yu, B. X. ; Yu, C. X. ; Yu, G. ; Yu, T. ; Yuan, C. Z. ; Yuan, L. ; Yuan, S. C. ; Yuan, X. Q. ; Yuan, Y. ; Yuan, Z. Y. ; Yue, C. X. ; Zafar, A. A. ; Zeng, F. R. ; Zeng Zeng, X. ; Zeng, Y. ; Zhan, Y. H. ; Zhang, A. Q. ; Zhang, B. L. ; Zhang, B. X. ; Zhang, D. H. ; Zhang, G. Y. ; Zhang, Haitao ; Zhang, H. H. ; Zhang, H. H. ; Zhang, H. Y. ; Zhang, J. L. ; Zhang, J. Q. ; Zhang, J. W. ; Zhang, J. X. ; Zhang, J. Y. ; Zhang, J. Z. ; Zhang, Jianyu ; Zhang, Jiawei ; Zhang, L. M. ; Zhang, L. Q. ; Zhang, Lei ; Zhang, P. ; Zhang, Q. Y. ; Zhang, Shulei ; Zhang, X. D. ; Zhang, X. M. ; Zhang, X. Y. ; Zhang, X. Y. ; Zhang, Y. ; Zhang, Y. T. ; Zhang, Y. H. ; Zhang, Yan ; Zhang, Yao ; Zhang, Z. H. ; Zhang, Z. Y. ; Zhang, Z. Y. ; Zhao, G. ; Zhao, J. ; Zhao, J. Y. ; Zhao, J. Z. ; Zhao, Lei ; Zhao, Ling ; Zhao, M. G. ; Zhao, Q. ; Zhao, S. J. ; Zhao, Y. B. ; Zhao, Y. X. ; Zhao, Z. G. ; Zhemchugov, Alexey ; Zheng, B. ; Zheng, J. P. ; Zheng, Y. H. ; Zhong, B. ; Zhong, C. ; Zhong, X. ; Zhou, H. ; Zhou, L. P. ; Zhou, X. ; Zhou, X. K. ; Zhou, X. R. ; Zhou, X. Y. ; Zhou, Y. Z. ; Zhu, Jianhui ; Zhu, K. ; Zhu, K. J. ; Zhu, L. X. ; Zhu, S. H. ; Zhu, T. J. ; Zhu, W. J. ; Zhu, Y. C. ; Zhu, Z. A. ; Zou, B. S. ; Zou, J. H.
The Born cross sections of the e+e− → D*+D*− and e+e− → D*+D− processes are measured using e+e− collision data collected with the BESIII experiment at center-of-mass energies from 4.085 to 4.600 GeV, corresponding to an integrated luminosity of 15.7 fb−1. The results are consistent with and more precise than the previous measurements by the Belle, Babar and CLEO collaborations. The measurements are essential for understanding the nature of vector charmonium and charmonium-like states.
Ablikim, Medina ; Achasov, Mikhail N. ; Adlarson, Patrik ; Ahmed, Samer ; Albrecht, Malte ; Aliberti, Riccardo ; Amoroso, Antonio ; An, M. R. ; An, Qi ; Bai, X. H. ; Bai, Yu ; Bakina, Olga ; Baldini Ferroli, Rinaldo ; Balossino, Ilaria ; Ban, Yong ; Begzsuren, Khurelbaatar ; Berger, Niklaus ; Bertani, Monica ; Bettoni, Diego ; Bianchi, Fabrizio ; Bloms, Johannes ; Bortone, Alberto ; Boyko, Igor R. ; Briere, Roy A. ; Brüggemann, Anja ; Cai, Hao ; Cai, Xiao ; Calcaterra, Alessandro ; Cao, G. F. ; Cao, N. ; Çetin, Serkant Ali ; Chang, Jinfan ; Chang, W. L. ; Chelkov, Gueorgui A. ; Chen, G. ; Chen, Hesheng ; Chen, M. L. ; Chen, S. J. ; Chen, X. R. ; Chen, Yuanbo ; Chen, Z. J. ; Cheng, W. S. ; Cibinetto, Gianluigi ; Cossio, Fabio ; Dai, Hongliang ; Dai, Xinchen ; Dbeyssi, Alaa ; Boer, Remco E. de ; Dedovich, Dmitri V. ; Deng, Ziyan ; Denig, Achim ; Denysenko, Igor ; Destefanis, Marco Giovanni Maria ; De Mori, Francesca ; Ding, Yanchun ; Dong, J. ; Dong, Liaoyuan ; Dong, Mingyi ; Dong, X. ; Du, Shuxian ; Fan, Y. L. ; Fang, J. ; Fang, Shuangshi ; Fang, Y. ; Farinelli, Riccardo ; Fava, Luciano ; Feldbauer, Florian ; Felici, Giulietto ; Feng, C. Q. ; Feng, J. H. ; Fritsch, Miriam ; Fu, Chengdong ; Gao, Y. N. ; Gao, Ya ; Gao, Yang ; Garzia, Isabella ; Ge, P. T. ; Geng, C. ; Gersabeck, Evelina ; Gilman, A. ; Goetzen, Klaus ; Gong, L. ; Gong, Wenxuan ; Gradl, Wolfgang ; Greco, M. ; Gu, L. M. ; Gu, Minhao ; Guan, C. Y. ; Guo, L. B. ; Guo, R. P. ; Guo, Yuping ; Guskov, Alexey ; Han, T. T. ; Han, W. Y. ; Hao, Xiqing ; Harris, Frederick Allan ; He, K. L. ; Heinsius, Fritz-Herbert ; Heinz, C. H. ; Heng, Yuekun ; Herold, Christoph ; Himmelreich, Mathilde ; Holtmann, Tobias ; Hou, G. Y. ; Hou, Y. R. ; Hou, Zhilong ; Hu, Haiming ; Hu, J. F. ; Hu, T. ; Hu, Y. ; Huang, G. S. ; Huang, L. Q. ; Huang, X. T. ; Huang, Y. P. ; Huang, Z. ; Hussain, Tahir ; Hüsken, Nils ; Imoehl, William ; Irshad, M. ; Jackson, J. ; Jaeger, S. ; Janchiv, S. ; Ji, Quan ; Ji, Qingping ; Ji, X. B. ; Ji, X. L. ; Ji, Y. Y. ; Jiang, H. B. ; Jiang, Xiaoshan ; Jiang, Y. ; Jiao, J. B. ; Jiao, Z. ; Jin, Shan ; Jin, Y. ; Jing, M. Q. ; Johansson, Tord ; Kalantar-Nayestanaki, Nasser ; Kang, X. S. ; Kappert, Rosa ; Kavatsyuk, Myroslav O. ; Ke, B. C. ; Keshk, I. K. ; Khoukaz, Alfons ; Kiese, P. ; Kiuchi, R. ; Kliemt, Ralf ; Koch, L. ; Kolcu, Onur Bugra ; Kopf, Bertram ; Kuemmel, M. ; Küßner, Meike ; Kupsc, Andrzej ; Kurth, M. G. ; Kühn, Wolfgang ; Lane, John Jake ; Lange, Jens Sören ; Larin, Paul ; Lavania, Anita ; Lavezzi, Lia ; Lei, Z. H. ; Leithoff, H. ; Lellmann, Max ; Lenz, Thomas ; Li, C. ; Li, C. 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We present the first experimental search for the rare charm decay D0→π0ν¯ν. It is based on an e+e− collision sample consisting of 10.6×10^6 pairs of D0¯D0 mesons collected by the BESIII detector at √s=3.773 GeV, corresponding to an integrated luminosity of 2.93 fb^−1. A data-driven method is used to ensure the reliability of the background modeling. No significant D0→π0ν¯ν signal is observed in data and an upper limit of the branching fraction is set to be 2.1×10^-4 at the 90% confidence level. This is the first experimental constraint on charmed-hadron decays into dineutrino final states.
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