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Wer ein Unternehmen gründet, geht ein Risiko ein: Das Vorhaben kann auch misslingen. Viele vermissen in Deutschland eine »Kultur des Scheiterns«, die Misserfolge verzeiht und den Mut der Gründer wertschätzt. Wie ein Blick auf die Gründerszene an der Goethe-Universität zeigt, ist der Mentalitätswandel aber bereits in vollem Gange.
If one thing can be learned from the recent boom in the apparently 'new' field of the 'history of the humanities', it is that, especially in the humanities, the history of an academic discipline is never mere history, because the research questions that inaugurate a discipline continue to subsist at its foundations. Knowledge in the humanities, it seems, develops differently. In many fields, 'progress' is far less linear than in the natural sciences; indeed, research programmes may shuttle back and forth between different epochs, with interpretations of the past continually shedding new light upon the present.
Neuronal calcium signals propagating by simple diffusion and reaction with mobile and stationary buffers are limited to cellular microdomains. The distance intracellular calcium signals can travel may be significantly increased by means of calcium-induced calcium release from internal calcium stores, notably the endoplasmic reticulum. The organelle, which can be thought of as a cell-within-a-cell, is able to sequester large amounts of cytosolic calcium ions via SERCA pumps and selectively release them into the cytosol through ryanodine receptor channels leading to the formation of calcium waves. In this study, we set out to investigate the basic properties of such dendritic calcium waves and how they depend on the three parameters dendrite radius, ER radius and ryanodine receptor density in the endoplasmic membrane. We demonstrate that there are stable and abortive regimes for calcium waves, depending on the above morphological and physiological parameters. In stable regimes, calcium waves can travel across long dendritic distances, similar to electrical action potentials. We further observe that abortive regimes exist, which could be relevant for spike-timing dependent plasticity, as travel distances and wave velocities vary with changing intracellular architecture. For some of these regimes, analytic functions could be derived that fit the simulation data. In parameter spaces, that are non-trivially influenced by the three-dimensional calcium concentration profile, we were not able to derive such a functional description, demonstrating the mathematical requirement to model and simulate biochemical signaling in three-dimensional space.
White Gods Black Demons
(2018)
Irony and humour have always been used to counter frustration, despair and to expose double standards. In these ten sharply polished stories, Mandishona explores the dark comedy that lies just beneath the surface of tragedy in Zimbabwean society in the last decade. His perceptions leave few untouched: politicians, new farmers, exiles, stranded queues and inflation that renders the currency worthless... Truth and morality are dispensable in a society where wealth is rewarded with respect, integrity marred by untruth, rumour displaces fact, and power is only interested in its own survival. Mandishona holds a mirror up to reality and without equivocation asks us to look at what is real: the likeness or the distortion and what it is we want to see.
White matter microstructural changes and episodic memory disturbances in late-onset bipolar disorder
(2018)
Background: Bipolar disorder (BD) has been associated with distributed network disruption, but little is known on how different clinical subtypes, particularly those with an earlier and later onset of disease, are related to connectivity changes in white matter (WM) tracts.
Methods: Diffusion tensor imaging (DTI) and volumetric measures were carried out in early-onset bipolar patients [(EOD) (n = 16)], late-onset bipolar disorder [(LOD)(n = 14)] and healthy controls (n = 32). We also computed ROI analysis of gray matter (GM) and white matter (WM) volumes using the regions with significant group differences in the DTI parameters. Cognitive and behavior measurements were analyzed between groups.
Results: Lower fraction of anisotropy (FA) in the right hemisphere comprising anterior thalamic radiation, fornix, posterior cingulate, internal capsule, splenium of corpus callosum was observed in the LOD in comparison with EOD; additionally, lower FA was also found in the LOD in comparison with healthy controls, mostly in the right hemisphere and comprising fibers of the splenium of the corpus callosum, cingulum, superior frontal gyrus and posterior thalamic radiation; LOD also showed worse episodic memory performance than EOD; no statistical significant differences between mood symptoms, WM and GM volumes were found between BD groups.
Conclusion: Even after correcting for age differences, LOD was associated with more extensive WM microstructural changes and worse episodic memory performance than EOD; these findings suggest that changes in the WM fiber integrity may be associated with a later presentation of BD, possibly due to mechanisms other than neuroprogression. However, these findings deserve replication in larger, prospective, studies.
'Do the erstwhile colonial settlers - who, unlike in most other parts of the postcolonial world, have decided in large numbers to make the country their permanent home - deserve equal recognition as members of the emergent nation?' South Africa has been reeling under the recent blows of an apparent resurgence of crude public manifestations of racism and a hardening of attitudes on both sides of the racial divide. To probe this topic as it relates to white South Africans, Afrikaans and Afrikaners, MISTRA, in partnership with the Friedrich Ebert Stiftung (FES) and the National Institute for the Humanities and Social Sciences (NIHSS), convened a round-table discussion. The discourse was rigorous. This volume comprises the varied and thought-provoking presentations from that event, including a keynote address by former president Kgalema Motlanthe, inputs from Melissa Steyn, Andries Nel, Mary Burton, Christi van der Westhuizen, Lynette Steenveld, Bobby Godsell, Dirk Hermann (of Solidarity), Ernst Roets (of Afriforum), Xhanti Payi, Mathatha Tsedu, Pieter Duvenage, Hein Willemse and Nico Koopman, and closing remarks by Achille Mbembe and Mathews Phosa. It deals with a range of issues around 'whiteness' in general and delves into the place of Afrikaners and the Afrikaans language in democratic South Africa, demonstrating that there is no homogeneity of views on these topics among white South Africans overall and Afrikaners in particular. In fact, in these pages, one finds a multifaceted effort to scrub energetically at the boundaries that apartheid imposed on all South Africans in different ways.