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Nach der Befreiung des Konzentrationslagers Theresienstadt am 9. Mai 1945 fand die dort seit Februar inhaftierte Journalistin Eva Noack-Mosse eine kleine Anzahl von Gedichten und Gedichtfragmenten auf "Fetzen armseligen Papiers [...] meist mit Bleistift gekritzelt, vielfach durchgestrichen und verbessert, oft verlöscht und schwer lesbar." Sie wurden der dort am 19. April 1945 verstorbenen Kunsthistorikerin und Dichterin Gertrud Kantorowicz zugeschrieben und gehörten zu der "unübersehbaren Flut" von Versen, die sich laut Hans Günther Adlers monumentaler Geschichte von Theresienstadt über das Lager ergoss. Er sah in den meisten nur "ein einsames Gesellschaftsspiel mit sich selbst," denn noch "ein klapperndes Versmaß verspricht mehr Schutz und Bestand als das Fristen eines zerhämmerten und gnadenlosen Daseins." Geht man aber von der persönlichen Bekanntschaft der jungen Gertrud Kantorowicz mit Stefan George und den hiermit verbundenen lange nachwirkenden Anregungen aus und wird ferner berücksichtigt, welche Rolle im George-Kreis die Antike-Rezeption gespielt hat, so ist es nicht mehr so verwunderlich, dass die meisten Theresienstadt-Gedichte Kantorowicz' in antikisierenden Versformen und im hohen Stil gehalten sind; das ist nicht nur eine unerhörte Verfremdung der herabziehenden und demütigenden Lagererfahrung, sondern auch ein Sich-Erheben über Schmutz, Gewalt und Ungeist, eine ganz persönlich geprägte poetische Selbstbehauptung und Widerstandshandlung. Diesen Zusammenhängen soll im Folgenden nachgegangen werden.
This paper presents a contrastive analysis of auto- and hetero-stereotypes of Bosnians and Germans. The analysis is based on data collected from respondents choosing from a list of 140 characteristics. The anonymous online questionnaire asked respondents to identify those characteristics that they considered to be connected with their own culture or with the other culture, and to give their reasons for their choice (in the case of the most important characteristics). The analysis based on this data reveals how Germans and Bosnians perceive themselves and each other. It also enables the compilation of a list of stereotypes based on the most frequently identified characteristics, which can be used as a basis for further analysis and interpretation. This first analysis is intended as a foundation for future analyses of ethnic stereotypes among Germans and ethnic groups in the western Balkans: Bosnians, Serbs and Croats.
Game Plan
(2018)
Atrial septostomy (AS) is recommended for pulmonary arterial hypertension (PAH)-associated right ventricular (RV) failure, recurrent syncope, or pulmonary hypertensive crisis (PHC). We aimed to evaluate the feasibility and efficacy of AS to manage PAH from infancy to adulthood. From June 2009 to December 2016, transcatheter atrial communications were created in 11 PAH patients (4 girls/women; median age = 4.3 years; range = 33 days–26 years; median body weight = 14 kg; range = 3–71 kg; NYHA-/Ross class IV; n = 11). PAH was classified as idiopathic (n = 6) or secondary (n = 5). History of syncope was dominant (n = 6); two with patent foramen ovale (PFO) admitted with recurrent PHC, three patients required resuscitation before AS. Three patients had PAH-associated low cardiac output. The average pulmonary arterial pressures (PAP systolic/diastolic) were 101/50 (±34/23); the corresponding systemic arterial pressures (SAP) were 99/54 (±23/11); and the mean ratio of PAPd / SAPd was 0.97 (±0.4). Percutaneous trans-septal puncture was uneventfully performed in nine patients; a PFO was dilated in two patients. There was no procedure-related mortality. The median balloon size was 10 mm (range = 6–14 mm); the mean catheter time was 174.6 ± 48 min; fluoroscopy time was 19.8 (±11) min. Syncope and PHC were successfully treated in all patients. The mean arterial oxygen saturation decreased from 97 ± 2 to 89 ± 11.7. One patient died awaiting lung transplantation, one continues to be listed; two patients received a reverse Potts-shunt, one patient died during follow-up; seven patients are stable with PAH-specific treatment. Percutaneous AS is an effective method palliating PAH-associated syncope, PHCs or right (bi-) ventricular heart failure.
Many cancers have the tumor suppressor p53 inactivated by mutation, making reactivation of mutant p53 with small molecules a promising strategy for the development of novel anticancer therapeutics. The oncogenic p53 mutation Y220C, which accounts for approximately 100,000 cancer cases per year, creates an extended surface crevice in the DNA-binding domain, which destabilizes p53 and causes denaturation and aggregation. Here, we describe the structure-guided design of a novel class of small-molecule Y220C stabilizers and the challenging synthetic routes developed in the process. The synthesized chemical probe MB710, an aminobenzothiazole derivative, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro. MB725, an ethylamide analogue of MB710, induced selective viability reduction in several p53-Y220C cancer cell lines while being well tolerated in control cell lines. Reduction of viability correlated with increased and selective transcription of p53 target genes such as BTG2, p21, PUMA, FAS, TNF, and TNFRSF10B, which promote apoptosis and cell cycle arrest, suggesting compound-mediated transcriptional activation of the Y220C mutant. Our data provide a framework for the development of a class of potent, non-toxic compounds for reactivating the Y220C mutant in anticancer therapy.
During the Late Cretaceous and early Cenozoic the Earth experienced prolonged climatic cooling most likely caused by decreasing volcanic activity and atmospheric CO2 levels. However, the causes and mechanisms of subsequent major global warming culminating in the late Paleocene to Eocene greenhouse climate remain enigmatic. We present deep and intermediate water Nd-isotope records from the North and South Atlantic to decipher the control of the opening Atlantic Ocean on ocean circulation and its linkages to the evolution of global climate. The marked convergence of Nd-isotope signatures 59 million years ago indicates a major intensification of deep-water exchange between the North and South Atlantic, which coincided with the turning point of deep-water temperatures towards early Paleogene warming. We propose that this intensification of Atlantic overturning circulation in concert with increased atmospheric CO2 from continental rifting marked a climatic tipping point contributing to a more efficient distribution of heat over the planet.
Analyses of scope reconstruction typically fall into two competing approaches: 'semantic reconstruction', which derives non-surface scope using semantic mechanisms, and 'syntactic reconstruction', which derives it by positing additional syntactic representations at the level of Logical Form. Grosu and Krifka (2007) proposed a semantic-reconstruction analysis for relative clauses like the gifted mathematician that Dan claims he is, in which the relative head NP can be interpreted in the scope of a lower intensional quantifier. Their analysis relies on type-shifting the relative head into a predicate of functions. We develop an alternative analysis for such relative clauses that replaces type-shifting with syntactic reconstruction. The competing analyses diverge in their predictions regarding scope possibilities in head-external relative clauses. We use Hebrew resumptive pronouns, which disambiguate a relative clause in favor of the head-external structure, to show that the prediction of syntactic reconstruction is correct. This result suggests that certain type-shifting operations are not made available by Universal Grammar.
According to Ogihara (1995), the usage of the embedded present in a speech report such as John said that Mary is in the room is restricted by the cause of John’s belief (the state that made John think that Mary is in the room): the present tense can be used only if this cause still holds at the time that John said that Mary is in the room is uttered.
This paper presents experimental evidence demonstrating that this is only one of the factors that licenses a felicitous usage of the embedded present tense. In particular, we show that the cause of belief still holding is not a necessary condition, and identify two additional, sufficient (but not necessary) factors: in cases of false belief, who is aware of the falsity of the belief and duration of the reported state. While these factors are independent, they collectively support the idea that the present tense encodes ‘current relevance’, even in embedded contexts (e.g. Costa 1972; McGilvray 1974). This gives rise to the question of how we can derive ‘current relevance’ and, in particular, whether previous analyses of the embedded present tense are adequately equipped to do so.
Zielsetzung: Beteiligung von Medizinstudierenden im Rahmen der konzeptionellen Entwicklung eines zielgruppenspezifischen und attraktiven allgemeinmedizinischen Lehrangebots im ländlichen Raum.
Methodik: Es wurde ein Fragebogen entwickelt, der die Bewertung der Studierenden hinsichtlich des aktuellen Ablaufs ihres Studiums, den späteren Berufswunsch sowie die Anforderungen an ein zu entwickelndes allgemeinmedizinisches Schwerpunktprogramm im ländlichen Raum erfasst. Mittels einer Online-Befragung wurden im Sommer 2015 alle Medizinstudierende ab dem vierten vorklinischen Semester (n=2.150) der Goethe-Universität Frankfurt einmalig befragt. Die statistische Auswertung erfolgte primär deskriptiv. Die persönliche Einstellung hinsichtlich der Bereitschaft, als Hausarzt tätig zu werden, wurde auf statistische Signifikanz überprüft. Zudem wurde erhoben, ob ein messbarer Zusammenhang zwischen der eigenen Herkunft und dem späteren Wunscharbeitsort besteht.
Ergebnisse: Von insgesamt 2.150 kontaktierten Studierenden nahmen 617 an der Befragung teil (Rücklaufquote=28,7%). Die Ergebnisse repräsentieren eine große Bandbreite an Ideen und Anregungen, die sowohl die Meinung von Befürwortern als auch eher kritisch gegenüber der Lehre in der Allgemeinmedizin eingestellten Medizinstudierenden widerspiegeln. Von dem geplanten Schwerpunktprogramm erwarten die Studierenden einen starken Praxisbezug ebenso wie das Kennenlernen administrativer sowie wirtschaftlicher Hintergründe zum Führen einer Praxis.
Schlussfolgerungen: Durch die Einbeziehung der Zielgruppe am Entwicklungsprozess bestand die Möglichkeit, das zu entwickelnde Schwerpunktprogramm auf die späteren Teilnehmer passgenauer zuzuschneiden. Zudem ist zu erwarten, dass die Beteiligung der Studierenden zu einer höheren Akzeptanz des Programms führt. Die gewonnenen Ergebnisse zur Gestaltung eines Lehrangebots können als Orientierung für die mögliche Entwicklung ähnlicher Schwerpunktprogramme an anderen medizinischen Fakultäten dienen.