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Wie kann die Verkehrswende in Hessen gelingen? Podiumsdiskussion über die Zukunft der Mobilität +++ Mehr als Wohnen: Einladung zur Abschlusstagung im Forschungsprojekt „WohnMobil“ +++ ISOE-Lehrveranstaltungen im Wintersemester +++ Gut gemeint, aber ungeeignet: EU-Verordnung zur Wasserwiederverwendung in der Landwirtschaft +++ Wissenskommunikation für eine nachhaltige Entwicklung +++ Green Talents zu Gast im ISOE +++ Studie „share“: Untersuchung zu free-floating Carsharing abgeschlossen +++ Soziale Aspekte technischer Innovationen: Beispiel SEMIZENTRAL +++ Forschungsprojekt MULTI-ReUse: Interaktive Wissensvermittlung +++ 10 Jahre Senckenberg Biodiversität und Klima Forschungszentrum +++ Frankfurter Wissenschaftsrunde diskutiert Zukunftsthemen „Smart City – Smart Education“ +++ Aus dem ISOE +++ Termine +++ Publikationen
Gedenken an Elmar Altvater +++ Buch zum transdisziplinären Forschungs- und Entwicklungsprojekt CuveWaters erschienen +++ „Brilliant Minds“ für die Nachhaltigkeitsforschung gesucht +++ Frankfurter Forschungsteam untersucht natürliche Bekämpfung exotischer Stechmücken +++ Lösungsstrategien für weniger Plastik in Flüssen und Seen +++ Matthias Bergmann zum Honorarprofessor der Leuphana Universität ernannt +++ Wassermanagement für Millionenstädte – Beispiel Coimbatore in Südindien +++ Behaviour Change für die Verkehrswende +++ Gewässerschutz: Abschlussveranstaltung im Forschungsprojekt NiddaMan +++ Soziale Ökologie an der Uni +++ UN-Weltwassertag: Lösungen für globale Wasserkrise liegen (auch) in der Natur +++ Aus dem ISOE: Neuer Wissenschaftlicher Beirat berufen +++ Termine +++ Publikationen
Wie ist ein nachhaltiger Umgang mit Plastik möglich? +++ Arzneimittelrückstände im Wasser – Fortbildung für Beschäftigte der Pharmazie +++ ISOE-Mobilitätsforschung unterstützt Wissenschaftlichen Beirat des VCD +++ Internationale Summer School für Nachwuchswissenschaftler*innen +++ Savannen-Ökosysteme nachhaltig bewirtschaften +++ Planungssicherheit für Kommunen: Den Wasserbedarf der Zukunft prognostizieren +++ ÖPNV-Forum Stuttgart: Ergebnisse der Studie Mobiles Baden-Württemberg +++ Was Geschlechtergerechtigkeit mit Klimapolitik zu tun hat +++ Mehr Klimaschutz durch "negative Emissionen"? Internationale Konferenz zu Chancen und Risiken neuer Technologien +++ Aus dem ISOE +++ Termine +++ Publikationen
In Carl Barks' 1963 comic strip "The Invisible Intruder", the bed becomes the main theme of the story. We get to know how Uncle Scrooge became a creative and successful entrepreneur. Since his parents were too poor to provide a proper sleeping place for their son, Scrooge had to sleep in a cabinet drawer. Therefore, Scrooge's only aim was to buy himself a bed. His capitalist creativity is, as he himself admits, driven by the "desire for a better bed." With the economic growth of his company, his bed becomes bigger too. But in the end, he throws out his enormous mattress because it is too sensitive to the vibrations caused by the money rammer in the money bin; and moreover, the investigation into the cause of the vibrations became far too expensive. Eventually, Scrooge is returning to his childhood bed: the cabinet drawer. What is striking about this story is not the idea that objects of everyday culture play a leading role within a narrative; it is the fact that the usual cultural function of furniture is altered in a significant way. The misapplication of the drawer draws attention to the object of everyday culture as signifier of the everyday experience in capitalist societies. The function of the bed is no longer defined by criteria of good sleep but of economic calculation. The bed thereby becomes an agency within the narrative that questions the stability of the cultural and linguistic semantics of the everyday. In the following, I will press the point that the representation of the bed in literary texts from Homer to Kafka can be read as an implicit linguistic theory of cultural signification.
Objective: Imaging studies in diffuse low-grade gliomas (DLGG) vary across centers. In order to establish a minimal core of imaging necessary for further investigations and clinical trials in the field of DLGG, we aimed to establish the status quo within specialized European centers.
Methods: An online survey composed of 46 items was sent out to members of the European Low-Grade Glioma Network, the European Association of Neurosurgical Societies, the German Society of Neurosurgery and the Austrian Society of Neurosurgery.
Results: A total of 128 fully completed surveys were received and analyzed. Most centers (n = 96, 75%) were academic and half of the centers (n = 64, 50%) adhered to a dedicated treatment program for DLGG. There were national differences regarding the sequences enclosed in MRI imaging and use of PET, however most included T1 (without and with contrast, 100%), T2 (100%) and TIRM or FLAIR (20, 98%). DWI is performed by 80% of centers and 61% of centers regularly performed PWI.
Conclusion: A minimal core of imaging composed of T1 (w/wo contrast), T2, TIRM/FLAIR, PWI and DWI could be identified. All morphologic images should be obtained in a slice thickness of ≤ 3 mm. No common standard could be obtained regarding advanced MRI protocols and PET.
Importance of the study: We believe that our study makes a significant contribution to the literature because we were able to determine similarities in numerous aspects of LGG imaging. Using the proposed "minimal core of imaging" in clinical routine will facilitate future cooperative studies.
In diesem Beitrag untersuchen wir Entwicklungstendenzen von Infrastrukturen in den Digitalen Geisteswissenschaften. Wir argumentieren, dass infolge (1) der Verfügbarkeit von immer mehr Daten über sozial-semiotische Netzwerke, (2) der Methodeninflation in geisteswissenschaftlichen Disziplinen, (3) der zunehmend hybriden Arbeitsteilung zwischen Mensch und Maschine und (4) der explosionsartigen Vermehrung künstlicher Texte ein erheblicher Anpassungsdruck auf die Weiterentwicklung solcher Infrastrukturen entstanden ist. In diesem Zusammenhang beschreiben wir drei Informationssysteme, die sich unter anderem durch die Interaktionsmöglichkeiten unterscheiden, die sie ihren Nutzern bieten, um solchen Herausforderungen zu begegnen. Dabei skizzieren wir mit VienNA eine neuartige Architektur solcher Systeme, welche aufgrund ihrer Flexibilität die Möglichkeit bieten könnte, letztere Herausforderungen zu bewältigen.
Wenn Literatur über biopolitische und technologische Entwicklungen nachdenkt, kommt sie selten ohne wertende Perspektiven aus. Begeisterten Ausblicken auf angeblich erwartbare oder zumindest möglich scheinende Segnungen technologischen Fortschritts in der Zukunft stehen skeptisch-warnende, dystopische Inszenierungen von Machbarkeitsphantasien und menschlicher Hybris gegenüber. Literarische Zukunftsbilder und die in ihnen zum Ausdruck kommenden Ängste oder Hoffnungen lassen sich daher nicht selten als mehr oder weniger geschickt verkappte Kommentare zu gesellschaftspolitischen Tendenzen der jeweiligen Gegenwart verstehen. Insbesondere das Weiterspinnen von bereits existierenden wissenschaftlichen Erfindungen, deren Potentiale kontrovers diskutiert werden, scheint sich hierfür anzubieten.
Un Jésus postmoderne
(2018)
[Rezension zu:] Thibault, Bruno: Un Jésus postmoderne. Les récritures romanesques contemporaines des Evangiles. - Leiden-Boston: Brill Rodopi 2017 - (Chiasma ; 37)
[Rezension zu:] Ette, Ottmar: WeltFraktale - Wege durch die Literaturen der Welt. - Stuttgart: J.B. Metzler Verlag 2017.
[Rezension zu:] Pillet, Fabien: Vers une esthétique interculturelle de la réception. - Heidelberg: Universitätsverlag Winter 2016.
Am Beispiel von zwei Ausstellungskatalogen historischer Ansichtskarten aus Troppau (Opava) vor 1945 geht der Aufsatz der Frage nach, wie in diesen beiden Medien regionale Kontinuitäten repräsentiert werden können. Die Verwendung deutscher neben tschechischen Ortsbezeichnungen sowohl auf den Karten selbst wie in den Kataloglegenden erweist sich dabei als Indikator für Brüche in der Identität, deren angemessene Repräsentation nicht trivial erscheint. Ansichtskarten als Medium sollen eine lokale oder auch nationale Identität über Räume und Zeiten hinweg vermitteln; sie müssen Sprache und Bild verbinden, welche aber unterschiedlich anfällig für Identitätsbrüche sind. Es wird versucht, die Problematik mit Hilfe von H.U. Gumbrechts Begriffsprägung einer erweiterten Chronotope zu beschreiben. Das erweist sich aber gegenüber der traditionellen historischen Methode bestenfalls partiell als Erkenntnisgewinn.
Die Entscheidung, "Flüchtling" zum Wort des Jahres 2015 zu erklären, bewirkte zweierlei: Sie rief Flucht und Vertreibung in das kulturelle Bewusstsein zurück und rückte ihre medialen Repräsentationsformen in das Blickfeld der Migrationsdiskurse. Der literarische Diskurs der Migration interessiert sich für ästhetische Darstellungsformen von Migrationsformen. Er hinterfragt festgefahrene Vorstellungsmuster und problematisiert die bedeutungskonstruierenden und -konstituierenden Schemata der Migration, zu denen auch die erzwungenen Formen Flucht und Vertreibung zählen. Der literaturwissenschaftliche Diskurs geht der Frage nach Figurationen des Flüchtlings nach und untersucht, in welchen kulturellen Bedeutungszusammenhängen Flüchtlingsfiguren verortet werden, an welchen poetischen Mitteln diese Verortung erprobt wird und welche Erkenntnisse aus dem literarischen Diskurs des Flüchtlings gewonnen werden können. Dieser Diskurs verlöre aber an Wirkung, würde er jene begriffliche Signifikanz nicht auch in ästhetischer Hinsicht begründen. Zugleich gilt es die Wechselwirkung des Literarischen und Gesellschaftlichen im methodischen Vorgehen zu berücksichtigen. Ohne die Wechselwirkung an dieser Stelle historisch vertiefen zu können, sollen die Semantiken, die der öffentlich-politische Diskurs dem Flüchtlingsthema bisher zugeschrieben hat, herangezogen werden, denn in diesen Semantiken lässt sich eine Symbolik erkennen, die Aufschlüsse über das Verständnis des Kulturellen nach einer Definition ex negativo geben kann: Symptomatisch ist die dreifache Annahme, Flüchtlinge betrachteten identitätsstiftende Kriterien der aufnehmenden Gesellschaft nicht als verbindlich, sie teilten deren Geschichte nicht und könnten daher auch nicht an deren Gedächtnishorizont teilhaben; dieses Verständnis erfasst den Flüchtling nicht als Phänomen kultureller und globaler Prozesse, sondern verortet ihn an den Grenzen des Eigenen im Sinne einer Erscheinung außerhalb des eigenkulturellen Raumes.
Vom 20. bis 22. September 2017 fand an der Philologischen Fakultät der Universität des Baskenlandes die nunmehr dritte internationale Fachtagung zu literarischen Repräsentationen von Heimat statt. Unter dem Motto "Unheimliche Heimaträume" widmeten sich die Referentinnen und Referenten mehrheitlich der deutschsprachigen Literatur seit 1918. Dennoch gab es auch dieses Mal eine Sektion zur baskischsprachigen Literatur.
Eine Studie zur fehleranalytischen Kompetenz der Studierenden in der Deutschlehrendenausbildung
(2018)
Die Fehleranalyse gilt seit langem als eine wertvolle Hilfe beim Fremdsprachenunterricht, weil sowohl Lernende als auch Lehrende dadurch wichtige Informationen über den Spracherwerbsprozess bekommen können. Auch die vorliegende Arbeit beabsichtigt mit Hilfe der Fehleranalyse zu Erkenntnissen über die fehleranalytische Kompetenz der künftigen Deutschlehrer zu gelangen. Ausgangspunkt dieser Studie war die Frage, ob es eine direkte Verbindung zwischen dem Sprachniveau und der fehleranalytischen Kompetenz der Studierenden gebe. An der Untersuchung haben 37 Studierenden der Gazi Universität teilgenommen, von denen sieben Rückkehrende aus Deutschland waren und über gute Sprachkenntnisse verfügten. Alle Probanden befanden sich im sechsten Semester und hatten sich im Rahmen der angewandten Linguistik ein semesterlang mit der Fehleranalyse befasst. Den Probanden wurden zwei Texte vorgelegt, deren Fehler sie identifizieren und anhand eines Rasters klassifizieren mussten. Es hat sich herausgestellt, dass bei der Fehleridentifizierung die Fremdsprachenkenntnisse ein entscheidender Faktor waren. Bei der Fehlerklassifizierung dagegen, schienen die Fremdsprachenkenntnisse eher eine untergeordnete Rolle zu spielen.
Zur Behandlung von chronisch entzündlichen Erkrankungen besteht nach wie vor ein dringendes medizinisches Bedürfnis, da die bisher eingesetzten Medikamente gerade in der Langzeittherapie zu schwerwiegenden Nebenwirkungen führen können. Um chronisch entzündliche Erkrankungen in Zukunft adäquat therapieren zu können, sind bereits verschiedene neuartige Ansätze in klinischer bzw. präklinischer Entwicklung. Ein möglicher Ansatz besteht in einer dualen Hemmung der mikrosomalen Prostaglandin E2 Synthase-1 (mPGES-1) und der 5-Lipoxygenase (5-LO). Im Rahmen dieser Arbeit wurden die Struktur-Wirkungs-Beziehungen (SAR) von zwei verschiedenen Leitstrukturen an der 5 LO und der mPGES 1 untersucht. Die erste Leitstruktur entstammt aus den Arbeiten von Waltenberger et al. und besitzt im Grundgerüst eine Sulfonamidstruktur. In dieser Arbeit ist es gelungen, durch eine gezielte Untersuchung der Struktur-Wirkungsbeziehungen, die Leitstruktur I an der 5 LO und der mPGES-1 in ihrer Potenz zu optimieren. Die Leitstruktur (IC50: 5-LO (zellfrei) = 5.7 µM, IC50: 5 LO (PMNL) = 3.7 µM, IC50: mPGES-1 = 4.5 µM) konnte durch Variation in allen drei Positionen modifiziert werden, so dass die optimierte Struktur 170 (IC50: 5-LO (zellfrei) = 2.3 µM, IC50: 5-LO (PMNL) = 0.4 µM, IC50: mPGES-1 = 0.7 µM) entstanden ist. Für die Verbindung 170 wurden die pharmakokinetischen Eigenschaften, wie Löslichkeit und metabolische Stabilität, sowie der Wirkmechanismus auf molekularer Ebene bestimmt. Ebenso konnte für Verbindung 170 auch in vivo anti-entzündliche Eigenschaften festgestellt werden.
Die zweite Leitstruktur stammt ebenfalls aus den Arbeiten von Waltenberger et al. und besitzt im Grundgerüst eine Mercaptobenzothiazol-Grundstruktur. Aufgrund der Ähnlichkeit zu den bekannten Pirinixinsäurederivaten wurde auch hier für die Untersuchung der Struktur-Wirkungs-Beziehungen zunächst eine Kettenverlängerung an der Alkylkette vorgenommen. Es ließ sich auch hier durch eine gezielte SAR, die Leitstruktur bis hin zum submikromolaren Bereich in Verbindung 219 optimieren. Gleichzeitig ist es gelungen in Verbindung 219 einer der am potentesten dual ausgeglichensten dualen 5 LO/mPGES-1 Inhibitoren zu identifizieren.
Zusammenfassend lässt sich sagen, dass in dieser Arbeit es gelungen ist durch gezielte Untersuchungen der Struktur-Wirkungs-Beziehungen zwei verschiedene Substanzklassen zu dualen 5-LO/mPGES-1 Inhibitoren zu optimieren. Ebenso konnte für Substanz 170 auch in vivo anti-entzündliche Eigenschaften festgestellt werden. Diese Arbeit soll dazu beitragen, das therapeutische Potential von dualen 5-LO/mPGES-1 Inhibitoren als anti-entzündliche Wirkstoffe in Zukunft besser einschätzen zu können.
Der ligandaktivierte Transkriptionsfaktor Farnesoid X Rezeptor (FXR) ist neben seiner Funktion als Regulator des Gallensäurehaushaltes auch in vielen anderen metabolischen Prozessen wie Glukose- und Lipidhomöostase involviert und besitzt antiinflammatorische Eigenschaften. Gerade bei hepatischen, gastrointestinalen und systemischen Erkrankungen erscheint FXR daher als interessante Zielstruktur zur Behandlung metabolischer Erkrankungen. Basierend auf den natürlichen Liganden von FXR, den Gallensäuren, wurde Obeticholsäure (OCA) als seminsynthetisches Derivat der endogenen Chenodesoxycholsäure zu einem potenten FXR-Agonisten entwickelt. OCA wurde in mehreren Studien auf seine therapeutische Wirkung bei hepatisch-entzündlichen Krankheitsbildern wie der primären biliären Cholangitis (PBC), der nicht-alkoholischen Fettleber (engl: non-alcoholic fatty liver disease, NAFLD) und der daraus folgenden nicht-alkoholischen Steatohepatitis (NASH) getestet. Mittlerweile ist OCA als Zweitlinientherapie der PBC auf dem Arzneimittelmarkt zuge-lassen. Neben OCA gibt es noch eine große Anzahl an weiteren FXR-Liganden, deren strukturelle Diversität von Steroiden bis nicht-steroidalen kleinen Molekülen (engl: small molecules) reicht. Trotz dieser Erfolge muss das Therapiepotential von FXR noch weiter ausgebaut werden. Die meisten verfügbaren Liganden besitzen in vitro zwar eine hohe Potenz, können in ihrem pharmakokinetischen Profil oder ihrer Selektivität gegenüber anderen nukleären Rezeptoren aber nicht überzeugen.
Die hier vorliegende Arbeit hat sich mit der Entwicklung unterschiedlicher Liganden für FXR beschäftigt und diese in vitro und teilweise auch in vivo charakterisiert, um sie entsprechend ihrer Wirkungsweise einzuordnen und ein besseres Verständnis der regulatorischen Funktion von FXR zu erlangen.
Modulation von FXR bezieht sich nicht nur auf die agonistische Aktivierung, sondern setzt sich auch mit Antagonismus auseinander. Neben einigen Krankheitsbildern, die aus einer Überexpression von FXR resultieren, werden Antagonisten als Werkzeug (engl: tool compound) zur Aufklärung von konformellen Veränderungen von FXR und deren Auswirkung auf bestimmte Signalwege benötigt. Für die Erforschung solcher FXR-Antagonisten sollte das Potential nicht-steroidaler Antirheumatika (engl: non-steroidal anti-rheumatic drugs, NSAIDs) als etwaige Leitstrukturen untersucht werden, da in einer Veröffentlichung von Lu et al. ein FXR-Antagonismus durch NSAIDs postuliert wurde. Beim Versuch der Reproduktion der Ergebnisse von Lu et al. mit den drei NSAIDs Ibuprofen, Indometacin und Diclofenac wurde festgestellt, dass die Effekte auf den ersten Blick antagonistisch erscheinen, aber bei genaueren biochemischen Untersuchungen zweifelsfrei als Zytotoxizität identifiziert wurden.
FXR-Antagonisten wie Guggulsteron oder Gly-MCA sind auf ihre therapeutische Wirksamkeit unter-sucht worden, aber die genaue Wirkweise ist noch nicht aufgeklärt. Aufgrund ihrer steroidalen Grundstruktur ist ihre Selektivität gegenüber anderen nukleären Rezeptoren fraglich. Die überschaubare Anzahl an publizierten nicht-steroidalen FXR-Antagonisten besitzt zwar moderate IC50-Werte, ihre strukturelle Diversität und Selektivität ist aber limitiert. Zur Entwicklung neuer potenter FXR-Antagonisten, die aus kleinen Molekülen (engl: small molecules) aufgebaut sind, wurde eine N-Phenylbenzamid-Leitstruktur ausgewählt. Diese Leitstruktur wurde im Rahmen der SAR-Unter-suchungen zur Entwicklung von Anthranilsäurederivaten als FXR-Partialagonisten innerhalb des Arbeitskreises entdeckt. Ausgehend von dieser Leitstruktur wurde eine mehrstufige, systematische SAR-Untersuchung durchgeführt, wodurch ein sehr potenter FXR-Antagonist entwickelt werden konnte, der anschließend umfangreich biochemisch auf FXR-Modulation, Selektivität, Löslichkeit, Toxizität und metabolische Stabilität charakterisiert wurde.
Neben dem Verständnis eines Modulationsmechanismus ist die konkrete Anwendung eines FXR-Liganden zu therapeutischen Zwecken von großem Interesse. Die Beteiligung von FXR in unterschiedlichen metabolischen Prozessen macht den Rezeptor zu einem begehrten Ansatzpunkt für die Wirkstoffentwicklung. Doch die Behandlung eines multifaktoriellen Krankheitsbildes (z.B. metabolisches Syndrom, NASH) sollte sich nicht nur auf einen der gestörten Signalwege beziehen, da diese Erkrankungen durch mehrere Faktoren ausgelöst oder beeinflusst werden. Der semisynthetische FXR-Agonist OCA zeigte innerhalb der FLINT-Studie sowohl antientzündliche und antifibrotische Effekte, als auch eine Verbesserung der metabolischen Parameter mit Blick auf NAFLD und NASH. Die lösliche Epoxidhydrolase (engl: soluble epoxidhydrolase, sEH) besitzt nachweislich anti-inflammatorische und antisteatotische Effekte in der Leber. Aus diesem Grund wurde eine Leitstruktur entwickelt, die eine duale Modulation aus FXR-Aktivierung und sEH-Inhibition erzeugt. Dafür wurden die Pharmakophore eines im Arbeitskreis entwickelten FXR-Partialagonisten sowie eines potenten sEH-Inhibitors miteinander verknüpft. Zur Weiterentwicklung einer ausgewogenen hohen Potenz beider Modulationsfaktoren wurden mehrere unterschiedliche SAR-Untersuchungen als translationales Projekt in mehreren Arbeiten durchgeführt. In der hier vorliegenden Arbeit konnten dieses SAR-Untersuchungen zusammengeführt und weiterentwickelt werden. Dabei wurde ein ausgewogener und hochpotenter dualer Modulator erhalten, der umfassend in vitro und in vivo charakterisiert wurde. Die gezielte duale Aktivität, die mit dieser Substanz erreicht wurde, führt in einem Krankheitsbild zu synergistischer Ergänzung zweier Therapieoptionen. Jedoch kann eine unerwünschte Promiskuität über verwandten nukleären Faktoren zu Nebenwirkungen führen. Die Ursache dafür kann eine saure Funktion darstellen. Ein sehr potenter nicht-azider FXR-Agonist mit einem subnanomolaren EC50-Wert konnte im Arbeitskreis entwickelt werden. Diese Verbindung ist FXR-selektiv, hat keinen toxischen Effekt auf HepG2-Zellen und eine moderate metabolische Halbwertszeit. Die qRT-PCR-Untersuchung direkter und indirekter FXR-Zielgene zeigte eine verstärkte Expression nach der Inkubation mit der nicht-aziden Substanz. Dadurch lässt sich das Prinzip der Nebenwirkungsminderung durch nicht-azide Verbindungen beweisen.
Insgesamt konnte in dieser Arbeit gezeigt werden, wie vielfältig und vielversprechend eine FXR-Modulation aufgebaut sein kann. Zum einen konnte über eine ausgeprägte biochemische Evaluation eine Differenzierung zwischen FXR-Antagonismus und Zelltoxizität bewiesen werden, worauf sich aufbauend eine genaue in vitro-Charakterisierung von neuen N-phenylbenzamidbasierten FXR-Antagonisten durchführen ließ, die ausgehend von einer moderat potenten Leitstruktur zu einer sehr potenten optimierten Substanz entwickelt wurden. FXR-Antagonismus und die dazu passenden tool compounds sind nicht nur von Bedeutung zum besseren Verständnis der unterschiedlichen Bindungsmodi des FXR, sondern auch potentielle Therapieansätze zur Behandlung von Krankheiten, in denen eine FXR-Überexpression stattfindet. Die agonistische Modulation von FXR wurde genauer betrachtet in der in vitro-Untersuchung nicht-azider FXR-Agonisten, die durch das Fehlen einer sauren Funktion ein hohes Maß an Selektivität und dabei eine geringe Toxizität aufwiesen. Synergistische Effekte zur Behandlung eines multifaktoriellen Krankheitsbildes durch die Kombination von FXR-Partialagonismus und sEH-Inhibition konnte durch die Entwicklung der potenten und balancierten Substanz sowohl in vitro als auch in vivo bewiesen werden, wodurch diese Verbindung ein vielversprechender Kandidat für weitere klinische Entwicklung ist.
Bridge International is a for-profit chain of private (pre-)primary schools employing technology to allegedly provide “high-quality, affordable education” in the Global South. Like many other actors, Bridge (cl)aims to bridge the global digital divide and to use information and communication technologies to realize development (“ICT4D”), in particular in sub-Saharan Africa. But are such projects really allowing the region to “catch up” with the rest of the world and strengthen its weak global standing? Not necessarily. Many projects’ implementation mirrors existing global power inequalities and may even reinforce them.1 Moreover, the technologies employed themselves augment these imbalances. The present contribution illustrates this, using Bridge as a case study.
Das Internet ist ein gigantisches Netzwerk von Maschinen. Während sich dessen konkrete Nutzung permanent weiterentwickelt, bleibt dessen Funktion im Kern doch immer der Austausch von Informationen. Die vielfältigen Institutionen der Internet Governance lassen sich als Versuch verstehen, diesen Austausch zu ermöglichen. Eine zentrale Rolle kommt dabei der Internet Corporation for Assigned Names and Numbers (ICANN) zu. Sie verwaltet das globale Adressbuch des Internets und legt so fest, wie weit das Netz des Internets reicht. Die technische Notwendigkeit einer solchen zentralen Instanz wird im Prinzip kaum bestritten. Zunehmend jedoch verschärfen sich die Konflikte darüber, wie weit deren Kompetenzen reichen und wer sie kontrollieren sollte. Letztlich, so möchte ich zeigen, geht es um die Frage, wieviel internationale Autorität in diesem Bereich der Internet Governance notwendig und legitim ist.
The discussion about the interplay between digital technologies and the process of globalization is often focused around the following question: who has access to global information networks and who benefits from digital communication technologies? These are essential questions and it can hardly be denied that they confront us with a series of political and ethical questions. However, we also need to recognize the ongoing digitalization of the globe, a process where more and more people are put on various kinds of maps...
Europe’s new digital borders
(2018)
The European Union’s (EU) external border framework is not only increasingly reliant on digital databases, but these databases are now set to become interoperable. By 2020, the European Commission (EC) aims to have a fully interconnected new architecture for identity management at the border in place. Based on biometric enrolment of all third-country citizens, Europe’s new digital borders raise a number of concerns, including suspicion, large-scale surveillance, and internal policing that spread well beyond the border site.
Border management today is embedded into a complex network of data collection and data analysis that provides authorities with knowledge about who (or what) attempts to cross the border. While still serving as physical chokepoints for the examination and extraction of dangerous, suspicious, or illegitimate elements from global flows of mobility, border operations therefore increasingly rely on a number of databases...
With the rise of big data, internet-of-things, machine learning, targeted advertising, face recognition algorithms, virtual assistants, cyberbullying, cyberstalking, and cyberwarfare, we find more and more people and policy makers around the world debating whether technological advances are helping us or hurting us. Such debates often focus on trying to figure out a way to balance the need to preserve human values with the desire to not interfere with technological progress. The central problem that arises then is what to do when values and progress come into direct conflict with each other. Should we err on the side of caution and rein in companies like Google, Twitter, and Facebook so they do not interfere with personal privacy and national democracy? Or should we take a more pioneering perspective and view the occasional rights violation as a necessary risk that can be outweighed by the rewards for medicine, manufacturing, and media? Or should we try to find a middle path and have tech companies and policy makers work together to develop guidelines for “responsible research and innovation”?
Almost a decade ago, the internet was celebrated as one of history’s greatest liberation tools. People have unparalleled access to information and a greater deal of freedom to express themselves without fear of censorship or reprisal. This enthusiasm was short-lived, however. Today’s internet is heaving with hate speech, censorship, fake news, misinformation, and all forms of extremism. Governments have tightened their grip on digital spaces, and tech companies have grown into nontransparent empires with immense influence on the world’s politics, economies, and societies. These changes have brought forward new terrains of conflict and have redefined the relationship between the citizen and the state.
Large-scale digitisation has brought cultural heritage objects and materials from the remotest places of the world to our computer screens. At first sight, this innovation seems to make cultural heritage accessible to everyone like never before. However, technological advances have not eliminated social inequalities between powerful and marginalized communities and ethical issues in communicating cultural heritage. These issues became much more vivid and obvious when the spread of cultural heritage reached the global scale.
Die re:publica 2018 in der Twitteranalyse: User Statistiken, beliebteste Tweets und insbesondere die Debatte um das Verhalten der Bundeswehr rund um die #rp18. Deskriptive Analysen und rudimentäres Textmining. Agenda-Setting durch die Bundeswehr? Vielleicht ein bisschen. For our international readers, the graphs are kept in english. R code and data here.
Die Habilitation des Berner Literaturwissenschaftlers Matthias N. Lorenz untersucht die intertextuelle Auseinandersetzung mit Joseph Conrads "Heart of Darkness" (1899) im deutschen Sprachraum. Intertextualität fasst Lorenz im Anschluss an Ulrich Broich und Manfred Pfister als "bewusst intendierte" und "deutlich signalisierte Beziehungen" zwischen Texten. In einem 'close reading' kommen zunächst Zeitgenossen Conrads zur Sprache. Auf eine Latenzzeit der Conrad-Rezeption in der Nachkriegszeit folgt in den 80er Jahren eine Renaissance. Das längste Kapitel ist den Conrad-Lektüren von sieben Autorinnen und Autoren aus den Jahren 1986-2012 gewidmet. Hier leuchtet Lorenz feministische, kapitalismuskritische und postkoloniale Transformationen von "Heart of Darkness" aus. Schließlich rückt das Thema der Traumatisierung von Europäern in der Konfrontation mit Gewalt in Afrika in den Mittelpunkt der Betrachtung.
Der Beitrag bietet eine Übersicht zu den Zusammenhängen zwischen Immaterialgüterrechten (IP [intellectual property]-Rechte), Privatautonomie und Innovation. Demnach beruht das IP-Recht auf der Annahme, dass erst die Kombination aus fungiblen Ausschließlichkeitsrechten und Privatautonomie – also die juristische Form der Marktwirtschaft – einen innovationsförderlichen Effekt verspricht. Dementsprechend kombiniert das geltende Recht ein hohes materielles IP-Schutzniveau mit einer weitreichenden Anerkennung der Privatautonomie der Berechtigten. Dieser Regulierungsansatz hat den Vorteil, dass sehr anpassungsfähige Rahmenbedingungen für Innovationen geschaffen werden. Wer für seine Innovation eine umfassende Exklusivität benötigt, kann unter Geltung der beiden genannten Prinzipien ebenso operieren wie Akteure, die auf IP-Schutz teilweise oder ganz verzichten möchten, weil ihnen dies unter den gegebenen Wettbewerbsbedingungen vorzugswürdig erscheint. Und doch erläutert der Beitrag, dass die naheliegende Folgerung zu kurz greift, der Gesetzgeber könne sich darauf beschränken, möglichst umfassende und zugleich fungible IP-Rechte zu kodifizieren, da der Markt stets für eine effiziente und auch sonst sozial wünschenswerte Ressourcenallokation sorge. Denn die mit ausschließlichen IP-Rechten verbundenen Transaktionskosten stehen diesem Ziel nicht selten im Wege. Damit zeigt sich, dass keine noch so elaborierte Vertragsrechtstheorie die Frage nach dem Sinn des logisch vorrangigen Eigentums erübrigt.
This paper revisits the macroeconomic effects of the large-scale asset purchase programmes launched by the Federal Reserve and the Bank of England from 2008. Using a Bayesian VAR, we investigate the macroeconomic impact of shocks to asset purchase announcements and assess changes in their effectiveness based on subsample analysis. The results suggest that the early asset purchase programmes had significant positive macroeconomic effects, while those of the subsequent ones were weaker and in part not significantly different from zero. The reduced effectiveness seems to reflect in part better anticipation of asset purchase programmes over time, since we find significant positive macroeconomic effects when we consider shocks to survey expectations of the Federal Reserve’s last asset purchase programme. Finally, in all estimations we find a significant and persistent positive impact of asset purchase shocks on stock prices.
Im Rahmen dieser Arbeit wurden sRNAs des halophilen Archaeons Haloferax volcanii hinsichtlich ihrer biologischen und ihrer regulatorischen Funktion charakterisiert.
Um einen Überblick über die biologischen Funktionen archaealer sRNAs zu erhalten, wurde eine umfassende phänotypische Charakterisierung von 27 sRNA-Deletionsmutanten im Vergleich zum Wildtyp ausgewertet. Im Zuge dieser phänotypischen Charakterisierungen wurden zehn verschiedene Wachstumsbedingungen, morphologische Unterschiede und Veränderungen in der Zellmotilität untersucht. Hierbei zeigten nahezu alle Deletionsmutanten unter mindestens einer der getesteten Bedingungen phänotypische Unterschiede. Durch den Verlust von sRNAs wurden sowohl sogenannte Gain-of-function als auch Loss-of-function Phänotypen beobachtet. Haloarchaeale sRNAs spielen eine wichtige Rolle beim Wachstum mit verschiedenen Salzkonzentrationen, mit verschiedenen Kohlenstoffquellen und beim Schwärmverhalten, sind jedoch weniger in die Adaptation an diverse Stressbedingungen involviert.
Zur näheren Charakterisierung der regulatorischen Funktion archaealer sRNAs wurden sRNA362, sRNAhtsf468 und sRNA479 mittels molekulargenetischer Methoden wie Northern Blot-Analyse und DNA-Mikroarray sowie bioinformatischer in silico-Analyse untersucht. Das Expressionslevel von sRNA362 konnte bestimmt und potentielle Zielgene für sRNAhtsf468 und sRNA479 identifiziert werden.
Eine vorangegangene Studie zeigte den Einfluss von sRNA30 unter Hitzestress und führte zur Identifikation differentiell produzierter Proteine in Abwesenheit der sRNA. In dieser Arbeit wurde mittels Northern Blot-Analysen die Expression der sRNA30 charakterisiert. Das Wachstum in An- und Abwesenheit von sRNA30 wurde bei 42°C und 51°C phänotypisch charakterisiert und der regulatorische Einfluss der sRNA auf die mRNA differentiell regulierter Proteine durch Northern Blot-Analyse überprüft. Eine Transkriptomanalyse mittels DNA-Mikroarray nach Hitzeschock-Induktion führte zur Identifikation differentiell regulierter Gene involviert in Transportprozesse, Metabolismus, Transkriptionsregulation und die Expression anderer sRNAs. Die differentielle Regulation des Proteoms nach Hitzeschockinduktion in An- und Abwesenheit von sRNA30 konnte bestätigt werden.
Desweiteren wurde in dieser Arbeit sRNA132 und deren phosphatabhängige Regulation der Ziel-mRNA HVO_A0477-80 näher charakterisiert. Eine Induktionskinetik nach Phosphatentzug bestätigte die Bedeutung von sRNA132 für die verstärkte Expression des Operons HVO_A0477-80 unter Phosphatmangel-Bedingungen und verwies auf die Existenz weiterer Regulationsmechanismen. Während vor und nach Phosphatentzug kein Unterschied bezüglich der Zellmorphologie von Wildtyp und Deletionsmutante zu erkennen war, führte das Wachstum mit einem starken Phosphatüberschuss von 5 mM zu einer Zellverlängerung der Deletionsmutante. Die Kompetition der nativen 3‘-UTR des Operons HVO_A0477-80 mit einer Vektor-kodierten artifiziellen 3‘-UTR legt eine Regulation über die Bindung von sRNA132 an die 3‘-UTR nahe. Der Transkriptomvergleich nach Phosphatentzug in An- und Abwesenheit von sRNA132 führte zur Identifikation des Phosphoregulons der sRNA. Zu diesem Phosphoregulon gehören unter anderem zwei Glycerinphosphat-Dehydrogenasen, Transkriptionsregulatoren, eine Polyphosphatkinase und eine Glycerolphosphodiesterase. Zudem waren die Transkriptlevel der beiden ABC-Transporter HVO_A0477-80 und HVO_2375-8 für anorganisches Phosphat und des Transporters HVO_B0292-5 für Glycerinaldehyd-3-Phosphat in Abwesenheit der sRNA verringert. Die beiden ABC-Transportsysteme für anorganisches Phosphat wurden im Rahmen dieser Arbeit deletiert und weiter charakterisiert. Es konnte gezeigt werden, dass das ABC-Transportsystem HVO_2375-8 bei geringen Phosphatkonzentrationen leicht induziert wird und das Transkriptlevel in Anwesenheit von sRNA132 erhöht ist. Wachstumsversuche der jeweiligen Deletionsmutante in direkter Konkurrenz mit dem Wildtyp zeigten, dass keiner der beiden ABC-Transporter den anderen vollständig ersetzen kann und der Wildtyp mit beiden intakten ABC-Transportern unter phosphatlimitierenden Bedingungen einen Wachstumsvorteil besitzt. In silico-Analysen der Promotorbereiche von sRNA und ABC-Transporter legen zudem die Existenz von P-Boxen nahe.
Berühmt sind Benjamins Überlegungen zum bürgerlichen Interieur vor allem im "Passagen-Werk". Weniger bekannt hingegen sind seine Reflexionen über eine eigenartige Form von Erzählraum, der sich in der Mitte seines Erzähler-Aufsatzes lokalisiert. 'Eigenartig' ist er, weil es dort weniger um mündliches oder schriftliches Erzählen geht, als vielmehr um filmische Projektionen. Was projiziert wird, sind nach Benjamin "Ansichten der eigenen Person, unter denen er ohne es inne zu werden, sich selber begegnet ist". Solche Begegnungen gehören weder zur Erfahrung dieser Person noch zu ihrer Selbsterzählung oder Autobiographie. Diese "Out-takes eines Lebens" werden unwissentlich aufgenommen, unbewusst aufbewahrt und am Sterbebett mechanisch projiziert. Benjamin modifiziert in seinem Erzähler-Aufsatz die geläufige, entscheidend filmische Vorstellung, dass einem kurz vor dem Tod noch einmal das ganze Leben vorgeführt werde: Die Vorführung, die hier stattfindet, projiziert nur die Momente, die nie wirklich zum eigenem Leben gehört haben. Um diese andere Erzählart und diesen anderen Erzählraum zu erkunden, muss die betreffende Stelle im Erzähler-Aufsatz zusammen mit Benjamins Schriften zum buckligen Männlein gelesen werden. Was sich durch diese Lektüre manifestiert, ist eine andere Theorie der erzählerischen Autorität und der Tradierbarkeit von "unvergesslichen" Erfahrungen.
Rettungsschirm
(2018)
Macht sich die Zweideutigkeit des "Rettungsschirms" im Deutschen vor allem in Gestalt seiner visuellen und metaphorischen Figurationen bemerkbar, fällt sie im Englischen schon auf wörtlicher Ebene auf. Denn das Englische kennt zwei unterschiedliche Worte für die benannte Sache, sodass der Schirm entweder als 'umbrella' ("Regenschirm") oder als 'parachute' ("Fallschirm") auftreten muss. So finden sich denn auch beide Varianten in der englischsprachigen Berichterstattung über die Eurokrise. Die entsprechenden Formulierungen 'rescue umbrella' oder 'rescue parachute' lassen sich dabei in der Regel als Übersetzungsversuche aus dem Deutschen erkennen. Darüber hinaus finden sich beide Varianten häufig in englischsprachigen Einlassungen deutscher Krisenkommentatoren, die für diese Einrichtung werben oder sie kritisieren wollen. Viele englischsprachige Fachpublikationen, in denen explizit von 'rescue umbrella/parachute' die Rede ist, stammen auch aus der Feder deutscher Autorinnen und Autoren. Dieser Befund lässt die Vermutung zu, dass es sich bei dem Rettungsschirm um eine genuin deutsche Wortschöpfung handeln könnte. Die Vermutung lässt sich durch eine Reihe sprachwissenschaftlicher Untersuchungen bestätigen, die sich mit der Metaphorik der Finanzkrise beschäftigt haben. Das Gesamtbild der unterschiedlich angelegten empirischen Studien lässt recht klar erkennen, dass der Rettungsschirm eine der dominierenden Metaphern im deutschen Krisendiskurs und offenbar auch ein spezifisch deutsches Sprachgebilde ist.
Software
(2018)
Software regiert die Welt. Software hat die alte Unterscheidung von Geist und Materie - aufgemischt. Im engeren, in der und durch die Informatik terminologisch gewordenen Sinn meint der Begriff die Programme, die auf Universalrechenmaschinen (als der Hardware) zum Laufen gebracht werden können. Aber auch deren Bedienungsanleitungen wurden weiland dazu gezählt. Ebenso sind auch die gemäß den Befehlen der Programme verarbeiteten Daten und Adressen nicht Hard-, sondern Software. Die ganze heutige Bilderwelt im Web und auf den Milliarden Handys, alle gestreamte und downgeloadete Musik, nicht anders als dieser Text hier (bevor er in Druck gegangen sein wird): Alles ist Software. Und nichts ist Software. Weil ja auch jenseits der Schrift auf Papier, der Spur im Vinyl, des Granulats von Silbersalzen, kurzum: im sogenannten Digitalen nichts ohne die physikalisch-elektrischen Zustände der es prozessierenden Schaltkreise geht. Insofern gilt: Es gibt keine Software. Es gibt nur das Milliardengeschäft der Illusion, dass alles Software sei. Vielleicht könnte man sagen, dass 'Software' zu nichts anderem ge- und erfunden wurde, als um genau diese 'coincidentia oppositorum' von Alles und Nichts zu bezeichnen - oder hinter ihrer Bezeichnung zu verstecken. Beide Seiten machen jedenfalls erklärlich, dass es ein eigenes Wort für die Sache brauchte. Als Fremdwort außerhalb des englischen Sprachraums kann die einmal etablierte Vokabel, ebenso Unklarheiten mit sich führen, wie sie als 'terminus technicus' (im Englischen wie in anderen Sprachen) auch für das genaue Gegenteil, nämlich wissenschaftliche Präzision, einstehen kann.
With the discovery of light beyond human visibility, scientists strove to extend the range of observation to invisible parts of the light’s spectrum. Realising that light of all frequencies is part the same physical phenomenon, brought a leap in understanding about electromagnetic waves. With the development of more advanced technology, detectors with higher sensitivity for adjacent frequencies to the visible were built. From this, with each new observable wavelength, more insight into otherwise invisible processes and phenomenons were observed. Hand in hand with this went the enhancement of the output power of corresponding sources. This has lead to higher sensitivity setups throughout the spectrum, leading to observations which have given a deeper understanding in various fields of science. Nowadays, detectors and emitters in many different regions of the invisible electro magnetic spectrum have found their way in our every day life. Innovations in technology has lead to practical applications such as X-rays in medicine, motion sensors and remote controls using infrared light, distance sensors and data transmission using radar and radio devices. The frequency regions above infrared are optically generated and below radar can be produced using electric methods. There is no straight line that separates these frequencies. There rather is a whole intermediate region known as the terahertz (THz) regime. Due to the lack of sensitive detectors and efficient sources, the THz frequency region has not been exploited for application use on a widespread basis so far. It combines properties from the surrounding frequency ranges which make it an ideal spectrum for various applications. Consequently, THz radiation and THz imaging are active fields of research.
The work presented in this thesis consists of the development and testing of novel THz imaging concepts, which uses a THz antenna coupled field effect transistor (TeraFET) detector. Two detection principles are applied using two different optical setups. The first uses a pulsed optical parametric oscillator (OPO) THz source where the optical output power is detected. The source relies on a nonlinear effect of a lithium niobate crystal to generate tunable THz pulses from a Q-switched pump laser. The THz signal is detected and amplified by a double stage operational amplifier for monitoring the real time 20 ns pulses on an oscilloscope where a signal to noise ratio (SNR) of ⇠ 25 at a frequency range from 0.75 to 1.1 THz is reached. Imaging of the area of interest with a resolution of 1.2 mm is achieved through raster scanning of the THz pulses. Also spectroscopy with a frequency resolution of ⇠ 50 GHz is demonstrated using a para-aminobenzoic acid sample. The second setup utilises two synchronised electronic multiplier chain sources where their output is mixed on the detector. To form a heterodyne detection setup, the intermediate frequency is fed to a lock-in amplifier which then amplifies the so called beat signal from the TeraFET detector. One source is fixed relative to the detector even through scanning to ensure a stable signal. This detection method allows for amplitude and phase detection for every scanning position, making numerical light field propagation and object reconstruction possible. Numerical focussing is a key feature achieving a lateral resolution of the input transmittance of ⇡ 2 mm.
After the introduction, the second chapter describes the setup, measurement results and challenges which arise using a TeraFET together with the pulsed THz source “Firefly-THz”. In the description of the setup, special attention is given to the shielding of the detector and the electronics. General findings discuss first the overall performance and later spectroscopy and imaging as application examples. Another subsection continues with potential noise sources before the chapter is concluded. Chapter three expands on the topic of Fourier optics from a theoretical point of view. First, parts of the theory of the Fourier Transform (FT) are set out for the reader and how the Fast Fourier Transform (FFT) results from the Discrete Fourier Transform (DFT). This approach is used for theoretical considerations and the implementation of a Fourier optic script that allows for numerical investigations on electro magnetic field propagation through an optical system. The boundary conditions are chosen to be practical relevant to make predictions on measurements presented in chapter four. The following fourth chapter describes the realisation of a heterodyne THz detection setup. Before the measurement results are presented, the setup and its electric configuration are shown. The results come close to the analytical predictions so that the same algorithm which propagates the field from an object to the Fourier plane is used to propagate the measured field back to the object. The influence of phase noise on the measurement results are discussed before simulation and measurement is compared. The last chapter in this thesis concludes on the findings in the pulsed THz detection and the heterodyne THz Fourier imaging and gives an outlook for both configurations.
En este estudio se describen dos nuevas especies de hemípteros del género Aleuropleurocelus (Hemiptera: Aleyrodidae): Aleuropleurocelus mexicanus Carapia y Sánchez sp. nov., encontrada en los estados de Coahuila, México, Puebla, Sonora, y Tlaxcala en hojas de Quercus agrifolia Née y Quercus sp., y Aleuropleurocelus anahuac Carapia y Sánchez sp. nov. encontrada en los estados de México, Morelos y Puebla en el envés de hojas de Quercus. Se proporcionan microfotografías de estructuras morfológicas de puparios y se discute la separación con otras especies ovales de Aleuropleurocelus.
Different response of Ptch mutant and Ptch wildtype Rhabdomyosarcoma toward SMO and PI3K inhibitors
(2018)
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (ERMS). They also show activation of Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling. Here we compared the therapeutic effectiveness and the impact on HH target gene expression of Smoothened (SMO) antagonists with those of the PI3K inhibitor pictilisib in ERMS with and without mutations in the HH receptor Patched1 (PTCH). Our data demonstrate that growth of ERMS showing canonical Hh signaling activity due to Ptch germline mutations is efficiently reduced by SMO antagonists. This goes along with strong downregulation of the Hh target Gli1. Likewise Ptch mutant tumors are highly responsive toward the PI3K inhibitor pictilisib, which involves modulation of AKT and caspase activity. Pictilisib also modulates Hh target gene expression, which, however, is rather not correlated with its antitumoral effects. In contrast, sporadic ERMS, which usually express HH target genes without having PTCH mutation, apparently lack canonical HH signaling activity. Thus, stimulation by Sonic HE (SHH) or SAG (Smoothened agonist) or inhibition by SMO antagonists do not modulate HH target gene expression. In addition, SMO antagonists do not provoke efficient anticancer effects and rather exert off-target effects. In contrast, pictilisib and other PI3K/AKT/mTOR inhibitors potently inhibit cellular growth. They also efficiently inhibit HH target gene expression. However, of whether this is correlated with their antitumoral effects it is not clear. Together, these data suggest that PI3K inhibitors are a good and reliable therapeutic option for all ERMS, whereas SMO inhibitors might only be beneficial for ERMS driven by PTCH mutations.
The production of hypernuclei is investigated for p̅+A→Λ‾+ΛA reactions in a covariant meson exchange approach. Besides the conventional pseudo-scalar (K) and vector (K*) channels, we study for the first time also contributions from the correlated πK scalar channel, described by the k/K*0 meson. Initial and final state interactions are considered by eikonal theory. The total and angular differential cross sections of the coherent process p̅+AZ→ΛA(Z−1)+Λ̅ are evaluated at the beam momenta 1:5…20 GeV/c within the meson exchange model with bound proton and Λ-hyperon wave functions. It is shown that the shape of the beam momentum dependence of the hypernucleus production cross sections with various discrete Λ states is strongly sensitive to the presence of the scalar k meson exchange in the p̅p→Λ̅Λ amplitude. This can be used as a clean test of the exchange by scalar πK correlation in coherent p̅A reactions.
Africa, UK, and Ireland: Writing Politics and Knowledge Production comprises 6 scholarly/nonfiction essays, 7 short stories, 67 poems, and 2 plays from writers and poets based in the UK, Africa and Ireland the diasporas. It focuses on politics and knowledge production acting as a vehicle in which the production of new knowledge between these three regions/countries intersects in the literary sphere. It dissects the scientific methods of producing knowledge through the act of producing new knowledge, it looks at the management of knowledge, the processing and sharing of knowledge, and dissects, artistically and critically. It further stresses the importance of the ownership of knowledge and how this knowledge shapes politics. The collection contains work from up-and-coming poets and writers, alongside established ones, also included are pieces from academic scholars, essayists, poets, writers of fiction, playwrights. Africa, UK, and Ireland: Writing Politics and Knowledge Production will prove useful to literary and language theorists, poetry collections, political sciences, social sciences and human sciences, general academia and readers, education departments and students.
A Dark Energy
(2018)
Don is the only child of a happy family full of love, but it does not last. At 6 years old Don s parents are burned in a fire through arson, and suspects his father s brother is the culprit. As the family fights over his father's wealth nobody wants anything to do with Don, particularly the Uncle whom he suspects of arson and ends up taking most of his father s wealth. After a difficult upbringing in orphanages and living with an abusive old man Don starts working as an agent in Central Investigations Organisation, Zimbabwe s security intelligence organisation. Despite this apparent success Don never deals with the existential dilemmas he has as a result of his childhood. He becomes a loner, he doesn't believe in love, marriage, or happiness... until he meets Lilian. Soon after he is called into the president s office to cover up an extramarital affair. When a political rival of the president, the corrupt defence minister, bones gets wind of the cover up and unsuccessfully tries to blackmail Don something terrible happens and Don becomes thrown back into the darkness. Straddling literary genres this novel explores themes related to family, love, politics, life and existence. It is the story of a man pushed to breaking point and how that, inevitably, impacts society.
A Conversation : A Contact
(2018)
This English/Shona edtion of How the Twins Grew Up brings authentic biographical stories of two twin brothers. The stories take place in their family circle, at school, at home or in the backyard. It is written as a realistic prose narrative with a humorous intonation, unexpected dramatic twists and interesting punch lines. The stories are short and concise, with effective endings and situations, full of laughter, caricature and absurdity. The book has been translated into 20 languages and has received several awards. For those who love humour and want to return to their childhood, these stories will come as a real refreshment and a unique artistic experience.
In poet and artist Elena Botts new poetry collection: epochs of morning light, we see a shimmering, variegated new voice; we hear: where the trees still talk to each other, and winter feels like a song... (from When I have died we will be here). We feel the weather of her emotions; a contract with the ethereal and the visceral, as when we stand within the short but large poem: blossoms back to under the earth: I felt your ghost move through me out past the Baltic as though you had been in my heart the whole time. In this sensual canvas, beauty never suffers from loneliness, nor the sublime. Each poem herein as Botts wanders memory and weaves tapestries of word worlds, reveals a true and original voice in modern poetry: allowing light to conquer darkness; darkness to defy the estate of the sun, and colors mixed in ways only an artist of the pen could fathom
Logbook written by a drifter
(2018)
Logbook written by a drifter, is a cycle of interlinked poems that deal with life, spirituality, language, philosophy, love and relationships. A main theme are relationships which have changed the character. Those which the character doesn't know how to deal with; which have make the character into a wreck, emotionally, psychologically, or spiritually: he is in a small space. This collection encourages us to keep those spaces, spaces of the drift, until we have faced our challenges, afterall sometimes drifting is all we can do!
Under The Steel Yoke
(2018)
In Under The Steel Yoke I hear the wailing of fellow citizens as leadership subversion takes root. When servants become masters- that is a subversion, waves of despair threaten our people. I attempt to reflect the resilience of fellow Zimbabweans as we fight on for survival, hope refuses to die. The ideals of the true liberators prick our collective conscience. These poems are meant to provoke debate about nation building and they are an assertion that there can never be peace without justice. These poems are the voices heard on the streets, in pubs, factories, churches, homes and wherever our people irk a living. These voices yearn for a glorious future.
This careful selection of short poems, I Threw a Star in a Wine Glass, originally written in Arabic and translated into English can offer you a passport to live for other planets never imagined. With love and soft fragrance, works the poet Fethi Sassi to realize a dream, that was until now, breathing in the depth of his personality.
Another collection of exciting stories, articles and poems by young South Africans. We hope you will enjoy them so much that you #Can't StopReading. All of these pieces have been read and enjoyed by thousands of readers on FunDza's online library. Each piece also has discussion and writing activities for reading clubs and classes.
Social Memory, Silenced Voices, and Political Struggle : Remembering the Revolution in Zanzibar
(2018)
This volume focuses on the cultural memory and mediation of the 1964 Zanzibar revolution, analyzing its continuing reverberations in everyday life. The revolution constructed new conceptions of community and identity, race and cultural belonging, as well as instituting different ideals of nationhood, citizenship, sovereignty. As the commemoration of the 50th anniversary of the revolution revealed, the official versions of events have shifted significantly over time and the legacy of the uprising is still deeply contested. In these debates, the question of Zanzibari identity remains very much at stake: Who exactly belongs in the islands and what historical processes brought them there? What are the boundaries of the nation, and who can claim to be an essential part of this imagined and embodied community? Political belonging and power are closely intertwined with these issues of identity and historyraising intense debates and divisions over precisely where Zanzibar should be situated within the national order of things in a postcolonial and interconnected world. Attending to narratives that have been overlooked, ignored, or relegated to the margins, the authors of these essays do not seek to simply define the revolution or to establish its ultimate meaning. Instead, they seek to explore the continuing echoes and traces of the revolution fifty years on, reflected in memories, media, and monuments. Inspired by interdisciplinary perspectives from anthropology, history, cultural studies, and geography, these essays foreground critical debates about the revolution, often conducted sotto voce and located well off the official stageattending to long silenced questions, submerged doubts, rumors and secrets, or things that cannot be said.
Arguably, one of the most polarising figures in modern times has been Robert Gabriel Mugabe, the former President of the Republic of Zimbabwe. The mere mentioning of his name raises a lot of debate and often times vicious, if not irreconcilable differences, both in Zimbabwe and beyond. In an article titled: Lessons of Zimbabwe, Mahmood Mamdani succinctly captures the polarity thus: It is hard to think of a figure more reviled in the West than Robert Mugabe and his land reform measures, however harsh, have won him considerable popularity, not just in Zimbabwe but throughout southern Africa. This, together with his recent stylised ouster, speaks volumes to his conflicted legacy. The divided opinion on Mugabes legacy can broadly be represented, first, by those who consider him as a champion of African liberation, a Pan-Africanist, an unmatched revolutionary and an avid anti-imperialist who, literally, spoke the truth to Western imperialists. On the other end of the spectrum are those who seemingly paying scant regard to the predicament of millions of black Zimbabweans brutally dispossessed of their land and human dignity since the Rhodesian days have differentially characterised Mugabe as a rabid black fascist, an anti-white racist, an oppressor, and a dictator. Drawing on all these opinions and characterisations, the chapters ensconced in this volume critically reflect on the personality, leadership style and contributions of Robert Mugabe during his time in office, from 1980 to November 2017. The volume is timely in view of the current contested transition in Zimbabwe, and with regard to the ongoing consultations on the Land Question in neighbouring South Africa. It is a handy and richly documented text for students and practitioners in political science, African studies, economics, policy studies, development studies, and global studies.
Kenya's War of Independence restores Kenyas stolen history to its rightful place, stripped of colonial interpretations. In this expanded and revised version of his 1986 booklet, Kimaathi, Mau Mau's First Prime Minister of Kenya, Durrani covers Mau Maus resistance to colonialism and neo-colonialism and reflects on its ideology, organisation and achievements. He sees Mau Mau in the larger context of Kenyas war of independence and looks at the influence of organised, radical trade unions as the engine of resistance, linking economic with political demands of working people. Additional chapters document the post-independence resistance by the underground December Twelve Movement-Mwakenya. Durrani captures the dynamism of transition from colonialism to neo-colonialism: Imperialism replaced colonialism, African elites replaced White Settlers, neo-colonial government replaced colonial government. Resistance changed from the War of Independence to War of Economic Independence. Worker and peasant resistance is evident once again. History is on the march.
This book looks at the third pillar of resistance to British colonialism peoples resistance, the others being Mau Mau and radical trade union movement. It brings together several aspects of peoples resistance to colonialism and imperialism before and after independence and includes resistance by nationalities, women, students, peasants and workers in what can only be described as peoples resistance. While Mau Mau and trade unions were essential in the liberation struggle, on their own they would have faced innumerable difficulties to achieve their goal. Peasants, nationalities, women, children and young people, students, independent churches, independent schools, all played a part in reinforcing the organized and ideology led resistance of Mau Mau and trade unions. Additional material is included to provide thought for reflections. The first two essays deal with the question of nationalities and with the contradictions between capitalism and socialism with the collapse of USSR. They point to the fact that that the struggle in Kenya influences, and is in turn influenced by, developments around the world. The next section is the presentation at the launch of Kenyas War of Independence in Nairobi on February 21, 2018. The final section contains solidarity messages from Shiraz Durrani, Abdilatif Abdalla and Kang'ethe Mungai at the event to commemorate and celebrate the revolutionary work of Karimi Nduthu held on March 24, 2018 at the Professional Centre in Nairobi.The Kenya Resists Series covers different aspects of resistance by people of Kenya to colonialism and imperialism. It reproduces material from books, unpublished reports, research and oral or visual testimonies. The three aspects chosen for the first three publications in the Series Mau Mau, Trade Unions and Peoples Resistance make up the three pillars of resistance of the people of Kenya.
It is due to the success of the trade union movement in the national liberation movement that the colonial government suppressed prominent trade unions and attacked TU leaders like Makhan Singh, Fred Kubai, Pio Gama Pinto and Bildad Kaggia. It also passed on colonial laws to the independent Kenya government so as to ensure that future trade unions were forced to take the non-radical approach to meet worker needs. They thus created imperialist-oriented and led trade unions that bedevil working class politics to this day. There are valuable lessons to be learnt from the history of the militant trade unions in Kenya and also from understanding how colonialism and imperialism enforced changes that made the trade unions ineffective after independence. The selections in this book recall relevant events in the history of the militant trade union movement in Kenya and record the contribution that the trade union movement made to Mau Mau and to Kenya's war of independence. The Kenya Resists Series covers different aspects of resistance by people of Kenya to colonialism and imperialism. It reproduces material from books, unpublished reports, research and oral or visual testimonies. The three aspects chosen for the first three publications in the Series - Mau Mau, Trade Unions and People's Resistance - make up the three pillars of resistance of the people of Kenya.
Background: Histological evidence suggests that autism spectrum disorder (ASD) is accompanied by a reduced integrity of the grey-white matter boundary. This has also recently been confirmed by a structural neuroimaging study in vivo reporting significantly reduced grey-white matter tissue contrast (GWC) in adult individuals (18–42 years of age) with ASD relative to typically developing (TD) controls. However, it remains unknown whether the neuroanatomical differences in ASD at the grey-white matter boundary are stable across development or are age-dependent.
Methods: Here, we examined differences in the neurodevelopmental trajectories of GWC in a cross-sectional sample of 77 male ASD individuals and 76 typically developing (TD) controls across childhood and early adulthood (from 7 to 25 years).
Results: Using nested model comparisons, we first established that the developmental trajectory of GWC is complex in many regions across the cortex and includes linear and non-linear effects of age. Second, while ASD individuals have significantly reduced GWC overall, these differences are age-dependent and are most prominent during childhood (< 15 years).
Conclusions: Taken together, our findings suggest that differences in GWC in ASD are unlikely to reflect atypical grey matter cytoarchitecture alone, but may also represent other aspects of the cortical architecture such as age-dependent variability in myelin integrity.
We use minutes from 17,000 financial advisory sessions and corresponding client portfolio data to study how active client involvement affects advisor recommendations and portfolio outcomes. We find that advisors confronted with acquiescent clients stick to their standards and recommend expensive but well diversified mutual fund portfolios. However, if clients take an active role in the meetings, advisors deviate markedly from their standards, resulting in poorer portfolio diversification and lower Sharpe ratios. Our findings that advisors cater to client requests parallel the phenomenon of doctors prescribing antibiotics to insistent patients even if inappropriate, and imply that pandering diminishes the quality of advice.
Die vorliegende Promotionsarbeit befasst sich mit der retrospektiven Untersuchung von dentalen Implantaten, die nach Augmentation mit einem synthetischen Knochenersatzmaterial Nanobone® (Artoss, Rostock, Germany) inseriert wurden.
Ziel der vorangegangenen Studie war die Untersuchung, ob durch die Verkürzung der Einheilzeit von 6 auf 3 Monaten ein vergleichbares Ergebnis an Knochenneubildung erreicht werden kann. Es konnte gezeigt werden, dass eine Sinusbodenaugmentation mit dem synthetischen Knochenersatzmaterial Nanobone® schon nach einer Einheilzeit von 3 Monaten ein suffizientes Implantatbett vorweist und somit eine langzeitstabile Implantatrestauration (3-Jahres Follow up) ermöglicht.
Im Rahmen des 10-Jahres Follow-up konnten 12 der insgesamt 14 Patienten klinisch nachuntersucht werden.
Somit standen für die durchgeführte Nachuntersuchung noch 24 der insgesamt 27 Implantate zur Verfügung.
Hiervon wurden 17 Implantate nach 3 Monaten und 7 Implantate nach 6 Monaten inseriert.
Zehn Jahre nach der primären Augmentation und zweizeitigen Implantation zeigten sich bei der Nachuntersuchung 22 der 24 Implantate stabil und reizfrei in situ.
Die Parameter, die in der klinischen Untersuchung erhoben wurden waren, neben der festen und stabilen in situ Insertion der Implantate, eine Periotest-Messung (Medizintechnik Gulden, Modautal, Deutschland), das Bluten auf Sondieren (Bleeding on probing, BOP), die Bestimmung des Plaqueindex sowie die Untersuchung des Weichgewebes auf Rezessionen und Weichgewebsdehiszenzen.
Zwei der 24 Implantate mussten explantiert werden, eines davon bereits ein Jahr nach Implantation aufgrund von progredienten Entzündungszeichen und Lockerung.
Dies entspricht einer mittleren Implantatüberlebensrate von 91,66% oder einer Verlustrate von 8,34%.
Anders als im 3 Jahres Follow-up zeigte sich im Gruppenvergleich 3- zu 6 Monaten ein deutlicher Unterschied mit einer Implantatüberlebensrate in der 6- Monatsgruppe von 100% (7 von 7 Implantaten in situ) zu einer Implantatüberlebensrate der 3-Monatsgruppe von 88,24% (15 von 17 Implantaten in situ).
Somit ergibt sich ein deutlich besseres Outcome 10 Jahre post implantationem im Sinne einer erhöhten Implantatüberlebensrate und einer niedrigeren Komplikationsrate für die 6-Monatskontrollgruppe im Vergleich zu den Patienten, bei denen bereits 3 Monate post augmentationem implantiert wurde.
Die vorliegenden Untersuchungen zeigen, dass die Langzeitergebnisse nach Verwendung von alloplastischen KEM NanoBone®, auch nach 10 Jahren, mit vergleichbaren Langzeitergebnissen zu autologen Knochenersatz zur Knochenaugmentation im Oberkieferbereich mit gegebenenfalls kombinierter Sinusbodenaugmentation und zweizeitiger Implantatversorgung einhergehen.
Whether Africa is developed or not, depends on how and what one addresses. Development is relative. Nonetheless, the fact is: Africa developed Europe; and thereby became underdeveloped. Addressed academically, the notion of development creates many questions amongst which are: Development in what? Whose development? Development for whom? Who defines development? In this volume, the development dealt with is polygonal; and touches on politico-economic sequels which also affect the social aspect. No doubt. Africa is abundantly rich in terms of resource and culture. Paradoxically, however, Africa is less developed economically compared to Europe thanks to the history of unequal encounters, among other reasons. We cannot emphasise enough the fact that Africas underdevelopment is the price of the development of Europe which is based on historical realities gyrating around Europes criminal past wherein slavery and colonialism enabled Europe to spawn its future capital and investment. How can anyone quibble about Europes development resulting from perpetual plunderage of Africa with impunity committed by European treasure-hunting adventurers? This volume prescribes Africas restorative recompense as the only way forward for the duo and the world.
Jostling Between 'Mere Talk' & Blame Game? : Beyond Africa's Poverty and Underdevelopment Game Talk
(2018)
One of the fundamental challenges in rethinking and remaking development in Africa from a Pan African perspective is that too much mere talk and blame game have played out at the expense of real action. The blame game and mere talk on Africas poverty and underdevelopment jam have remained printed in bold on the face of the continent, yet Africas dire situation warrants nothing less than real emphatic action. This book focuses on the empirics of the production and reproduction of poverty and underdevelopment across Africa in a fashion that warrants urgent pragmatic policy attention and quest for workable homegrown solutions to persistent predicaments. The volume advances the need to recognise the realities of global inequalities and move swiftly in a most informed and transparent manner to address the poverty and underdevelopment conundrum. The book sets the tempo and pace on the need for praxis and pragmatism on the African situation. It is handy to students and practitioners in African studies, poverty and development studies, global studies, policy studies, economics and political science.
Poetic encounter: Rhapsodies from the South is compilation of poems by Southern African Writers from South Africa and Zimbabwe. The poems, were written not only to depict life but also tell tales of socio-political and economic history that Southern African people traversed from colonialism, apartheid to freedom. Therefore, readers from all walks-of-life can identify with themes such as apartheid, economic deprivation, religion and culture, love and so forth that are carefully ensconced in this compilation. The authors invite the readers, to not only indulge the lived injustice and violent nature of both our historic past and trajectory to the current state of affairs, but also appreciate, cry, smile and reminiscence about the life in general as encapsulated in this refreshing and aesthetic work of art - the poetic encounter.
As part of its on-going public dialogue program on progress in Ethiopia's development and public policy the Forum for Social Studies is undertaking a project of research and public dialogue on a number of selected topics on the theme of 'Prospects and Challenges for Inclusive and Participatory Development in Ethiopia'. The aim is to enable researchers and professionals to present evidence-based papers to stimulate debate and reflection. This first book in the program looks at the impact of development or lack of it, on specific social groups, namely women, young people and vulnerable groups that should be entitled to decent social care.
School Development Through Teacher Research : Lesson and Learning Studies in Sweden and Tanzania
(2018)
School Development through Teacher Research - Lesson and Learning Studies in Sweden and Tanzania presents the results from a three-year-long joint research project conducted by educational researchers from Tanzania and Sweden. Even though the country contexts differ in social, economic as well as educational conditions, including teacher education and classroom standards, many recurrent education challenges are shared. These include the tendency to make educational reforms with little or no input from professionals. The new educational reforms in both countries put a much higher responsibility on teachers; teachers must be able to organise teaching that enables all students to develop required abilities/competencies. Thus, teachers need tools to develop knowledge that can contribute to their professional knowledge base. With an overall interest in issues of teaching and action research, this joint project aimed to use Lesson and Learning Study as models for developing and improving the quality of teaching and learning in schools. The research project was realised through four case studies in each country with a focus on students' development of specific capabilities and values Science, Vocational Skills/Home and Consumer Studies, English as second language and Mathematics in grades 6-7. Complementing the cases School Development through Teacher Research - Lesson and Learning Studies in Sweden and Tanzania offers an introductory background to Lesson and Learning Studies as models for teacher-driven research and school development. The book is written to support teachers and teacher educators' wishing to reflect about learning and the struggle of learners to discern various concepts, principles and practices. As well as those who genuinely wish to see serious learning take place, rather than simply seeing content 'covered' - including curriculum designers and developers, educational researchers, educational supervisors and leaders and student-teachers as well as students of pedagogy and didactics. We dedicate the book to teacher educators, teachers and school leaders who are seriously striving to enhance students' learning and understanding in different subject areas.
A Son of Two Countries is a story of struggle for education. Born in 1946 in Rwanda under Belgian colonial rule, the author recounts his early education in Rwanda and later as a refugee in Tanzania. He was naturalized as a Tanzanian citizen in 1980 while doing his undergraduate studies at the University of Dar es Salaam. As he struggled to get education, the author was also grappling with his refugee status, with all the challenges that it entailed. The book gives insights into the contradictions of colonial and post-colonial education, as well as the author's reflections on education in Tanzania, given his long experience in the education sector in that country. Finally, we get some glimpses into the dual identity of the author as a Tanzanian citizen of Rwandan origin and how this shaped his relationship with the two countries he calls home. As he aptly puts it, 'Rwanda gave me my heart; Tanzania gave me my brain. I find it difficult to choose between my heart and my brain'.
It was not the European and American churches which evangelised Africa, but the mission societies. The missions from the Great Awakening such as the London Missionary Society and Church Missionary Society, or the Holy Ghost Fathers and the White Fathers, which started the process of Sub-Saharan Africa becoming a Christian continent are well known and documented. Less known, and less documented are the interdenominational faith missions which began in 1873 with the aim of visiting the still unreached areas of Africa: North Africa, the Sudan Belt and the Congo Basin. Missions such as the Africa Inland Mission or Sudan Interior Mission gave birth to some of the big churches like ECWA in Nigeria and Africa Inland Church in Kenya. It is the aim of this book to describe faith missions and their theology and to present an overview of the early development of faith missions insofar as they touched Africa.
Homosexuality is a cross-cutting challenge to Malawian society with theological, socio-cultural, economic, legal, political, and human rights implications. This book argues that the solution to the homosexuality debate in Malawi does not lie in either the criminalization or decriminalization of homosexuality; neither does it lie in homophobia nor heterophobia. However, the solution to the homosexuality debate lies in achieving a harmonious co-existence of both heterosexuals and homosexuals by practicing mutual tolerance. The book concludes by suggesting various activities to be taken by: The Government of Malawi; Gay Rights Activists; Religious Leaders; Traditional Leaders; and Malawian Society to ensure the aforementioned tolerance and understanding is encouraged.
The missionary work of the Seventh-day Adventist Church started in Southern Malawi in 1902, and histories of churches are usually told from that starting point. This book uses a different approach, it tells the story of Lunjika Mission (earlier called Mombera Mission) which begins in 1932, showing how the SDA Church met a new culture, that of the strongly patrilineal Ngoni and their neighbours to the North, and how it dealt with other churches that had started missionary work in that broad area up to two generations before.
Some scholars classify the Last Church of God and His Christ under the ecclesiastical-cultural bloc known as African Indigenous Churches (AICs). David Barret has divided the world's Christians into seven major ecclesiastical blocs. However, there are many large churches and denominations which do not define themselves under any of these three terms, and often reject all three. As far back as 1549 (Japan) and 1741 (USA), new types of Christianity have emerged that do not fit readily into any of these preceding six major blocs. These consist of denominations, churches and movements that have been initiated, founded and spread by black, Non-White or non-European peoples without European assistance, mainly in the Global South, but also among Black and Non-White minorities in the Western World. The African Indigenous Churches fall under this category. The aim of the book, is to examine the history of the Last Church of God and His Christ International in Malawi from its beginning (1916) through the years and to portray a picture of its current existence in its various branches: What developments and changes have taken place over the years? What has been the relationship of the church to African culture? How has the church grown or expanded? Has the church been able to maintain its unity? And what has been the relationship of the church with other churches?
Stephen Kauta Msiska was ordained to the ministry in 1945 and served the Livingstonia Synod in a number of lakeshore parishes before being appointed ?rst a tutor and later Principal of the united CCAP Theological College at Nkhoma where he taught from 1962 to 1974. His ?rm stand for what he understood to be the principles of the Christian Gospel led to a clash with the one-party regime and he was forced to ?ee to his home village and to live there in relative obscurity. This book makes accessible some of the fruits not only of his years of active pastoral ministry and theological teaching but also of his time of lonely suffering and sorrow. Distinctive in the writing of this pioneering theologian is a profound, though not uncritical, sympathy with the traditional religion of his people combined with a passionate concern for authentic Christian discipleship. Careful readers of this original and thoughtful book will ?nd the 'golden buttons' which Stephen Kauta is determined should not be lost.
The English-Ciyawo dictionary has been designed to help Yawo learners improve their English language skills for undertaking secondary school and university in the following ways: It helps a Yawo learner identify and learn the 3,000 most important and frequently used words in the English language. It gives a learner the most important meanings of each English word. It shows a learner how an English word is used in a sentence and also gives a translation of each sentence in Ciyawo to help a learner fully grasp the meaning.
Writing Namibia: Literature in Transition is a cornucopia of extraordinary and fascinating material which will be a rich resource for students, teachers and readers interested in Namibia. The text is wide ranging, defining literature in its broadest terms. In its multifaceted approach, the book covers many genres traditionally outside academic literary discourse and debate. The 22 chapters cover literature of all categories in Namibia since independence: written and performance poetry, praise poetry, Oshiwambo orature, drama, novels, autobiography, womens writing, subaltern studies, literature in German, Ju|hoansi and Otjiherero, childrens literature, Afrikaans fiction, story-telling through film, publishing, and the interface between literature and society. The inclusive approach is the books strength as it allows a wide range of subjects to be addressed, including those around gender, race and orature which have been conventionally silenced.
Migration has assumed growing significance in the global development agenda as its potential for economic and social development is increasingly acknowledged. Within the Africa context, perceptions of migration as a negative phenomenon have shifted to recognition of its central role to Africa's transformation. Despite this shift, emerging migration dynamics have not been adequately contextualized and conceptualized, making it difficult to integrate migration into development planning processes. This book attempts to fill the gaps in migration knowledge production, particularly from the perspectives of researchers in the global south and more specifically from Ghana. The chapters provide multi disciplinary perspectives in the contemporary migration landscape in Ghana and Africa. Rather than focus on migration as a problem to be solved, the chapters explore migration as an intrinsic part of the broader processes of structural change in Ghana, which could create opportunities for development if properly harnessed. This reader is an essential resource for migration and development researchers, students, policy makers, practitioners and others interested in the field of development.
Millions of Ghanaians live with diabetes, hypertension, stroke, cancers and other major chronic diseases. Millions more are at risk of getting these conditions. Individuals living with chronic conditions experience many disruptions, especially at the early stages of diagnosis and adjustment. The disruptions are physical (medical complications), psychological (depression), material (impoverishment), social (stigma) and spiritual (struggles with faith and trust). These experiences have an impact on family life and resources, with primary caregivers bearing similar disruptions to their chronically ill loved ones. While chronic conditions cannot be cured, many individuals hope for a cure. This hope drives healthcare seeking across different sectors of Ghanas vibrant pluralistic health system. When hope for a cure meets claims to cure within the herbalist and faith healing sectors, especially, the outcomes for individuals and their families can be catastrophic. The Ghanaian situation is mirrored in many African countries. It is estimated that African chronic non-communicable disease (NCD) prevalence, morbidity and mortality rates will rise faster than rates in Asia and Latin America over the coming decades. The long term and costly nature of NCDs has major implications for individuals, communities, health systems and governments. In this inaugural lecture, Professor Ama de-Graft Aikins discusses the psychology of chronic disease risk, experience and care in Africa. She makes a case for why the problem of NCDs needs to be examined through a psychological lens. She draws on her independent and collaborative work on diabetes representations and experiences among Ghanaians in Ghana and Europe, and the broader African and global health literature, to highlight the complex multi-level context of chronic disease risk, experience and care. She presents a synthesis of the evidence through the concepts of physical ills and ideological ills, arguing that both are interconnected and, as a result, must be addressed through interdisciplinary approaches. She concludes by offering practical solutions for reducing chronic disease risk and improving the quality of long-term experience and care in Ghana, using examples from countries that have implemented successful NCD interventions.
Speaking of Mauritius as an economic miracle has become a cliché, and with good reason: Its development since Independence in 1968 can easily be narrated as a rags-to-riches story. In addition, it is a stable democracy capable of containing the conflict potential inherent in its complex ethnic and religious demography. This book brings together some of the finest scholarship, domestic as well as foreign, on contemporary Mauritius, offering perspectives from constitutional law, cultural studies, sociology, archaeology, economics, social anthropology and more. While celebrating the indisputable, and impressive, achievements of the Mauritian nation on its fiftieth birthday, this book is far from toothless. Looking back inevitably implies looking ahead, and in order to do so, critical self-scrutiny is essential, to be able to learn from the mistakes of the past. The contributors raise fundamental questions concerning a broad range of issues, from the dilemmas of multiculturalism to the marginal role of women in public life, from the question of constitutional reform and the continued problem of corruption to the slow destruction of Mauritius joy and pride, namely the beauty and purity of its natural scenery. Taking stock of the first fifty years, this book also looks ahead to the next fifty years, giving some cues as to where Mauritius can and should aim in the next decades.
African agriculture faces major challenges with growing population pressure and the impact of climate change. Until now food production overall has broadly kept pace with demand. To maintain this impressive achievement, production from the land needs to be intensified, soil fertility must be enhanced, forests and water resources must be conserved, and land use practices must be sustainable over the long term. This book shows what needs to be done, and points to how best to achieve this. The book starts with a brief guide to what plants and animals need to grow well, how farmers currently use the land, and the research that is being conducted on new agricultural technologies. A comparison is made of productivity on small and large farms, which demonstrates that, contrary to some suggestions, small farmers, properly serviced, can be as productive or even more productive than larger farms. Subsequent chapters discuss issues of land tenure, pastoralism, training, the importance of women farmers, access to finance, markets, value chains, and contract farming as a partnership between small-scale producers, processors and traders in agricultural products. The final section of the book discusses whether a new 'green revolution' is feasible or desirable for Africa. The potential risks and benefits of dependence on purchased agrochemicals, genetically modified varieties, and multinational seed and chemical companies are examined. A series of twelve broad policy proposals for achieving a sustainable agriculture sector is presented for consideration. Fifteen case studies illustrate the issues discussed in the book. Most of the examples are from East Africa, particularly Tanzania, but the principles addressed are relevant across the African continent. Each chapter of the book includes references and suggestions for further reading, most of them freely available to anyone with internet access. A set of essay questions exploring the issues covered in each chapter is included, to provide practical help for students of agriculture and their teachers.
The most fundamental difference between developing and developed societies is technology, in a broad yet specific sense; so states the author of this important study, Liberation and Technology: Development possibilities in pursuing technological autonomy. The ways in which technology is developed, institutionalized, animated and celebrated, form the core of development (human, economic, environmental, etc.) and ultimately civilization itself. But techno-spheres are not only technical. They are also social, political, and ideological. For societies and countries that have long been kept from realizing their own prosperity and dignity, development is also liberation. The main treatise of this book is that each developing society ought to seek to achieve technological autonomy in its quest for positive transformations and prosperity for its people. Technological autonomy is about attaining a high level of self-determination in planning and managing technological affairs. Attaining endogenous capacity to guide and execute decisions on production and innovation; creating and transferring key technological products and services; steering relevant foreign and local investment as well as trade; setting own priorities of development free from external manipulation; are goals that must be central to such planning efforts. With evidence and argument, and in plain language, this book suggests a novel way of thinking about development, through envisioning and building better techno-social systems. For these reasons this book is a welcome addition to the body of ideas informing practitioners and theorists in the field of developmentpolitical leaders, economists, sociologists, engineers, technologists, scientists, scholars, planners and activists who are involved in relevant development processes and liberation struggles.
Religious Conversion: An African Perspective includes a selection of key texts which are not easily accessible elsewhere. Most of the chapters discuss the long-standing thesis of Robin Horton who argues that religious change results from social transformation. The contributors provide different perspectives on what remains an ongoing provocative, though inconclusive debate. The book has chapters on conversion in Africa from such authorities as Robin Horton, Humphrey Fisher, and Richard Gray. It also contains chapters on Zambia by Elizaebeth Colson, Brendan Carmody, Austin Cheyeka, Felix Phiri and W Van Binsbergen. This collection of chapters provides an introduction to the discussion surrounding the query: Did the Christian and Muslim messages bring something fundamentally new to the African religious horizon? What has indigenisation meant? What is the role of traditional religion?
The National Cohesion and Integration Commission (NCIC) was set up to facilitate and promote equality of opportunity, good relations, harmony and peaceful coexistence between persons of the different ethnic and racial communities of Kenya, and to advise the Government on all aspects thereof after the violence that followed the December 2007 elections. In Kenya, Bridging Ethnic Divides: A Commissioner's Experience on Cohesion and Integration, Commissioner Alice Wairimu Nderitu looks behind the scenes at the NCIC's efforts to ensure peaceful co-existence. Such as, working with elders, mediating confidentially between political leaders at the highest levels and co-founding and working as first Co-Chair of Uwiano Platform for Peace, a conflict prevention agency largely credited with leading efforts in ensuring peaceful processes during the 2010 Constitutional referendum and 2013 General elections. The book tells of NCIC's efforts in grappling with the seemingly intractable problem of managing the negative consequence of ethnic differences on questions such as: Why is Kenya so ethnically polarised? Why is an ethnic group the key defining factor in Kenyan politics? What hope is there for an inclusive Kenya? The book shows that positive policies and intra- and inter-ethnic spaces can be used to counter negative influences that lead to fear, exclusion and violence. The diversity of Kenya's ethnicities and races need not be a pretext for conflict, but a source of truly national identity. It proves that dialogue on understanding differences and commonalities leads to improved relationships and understanding on societal dynamics. This in turn, contributes to preventing and transforming conflicts through appropriate inclusion policies, identifying entry points for change as well as opportunities to tackle the norms and behaviours that underpin structural disparities.
Very few countries hide or obscure the significance of their most important historical achievements. Kenya has managed to do so without any regrets or even a thought about the implication of such a major oversight in connection with Mau Mau Resistance. The reason for this underplay is not difficult to understand. The government that came to power at independence was not only not part of the Mau Mau movement which fought for land and freedom for working people, but actively opposed it. It sought and was given by the departing colonial power state power, land and freedom for its class, thereby sidelining the radical resistance movement and its activists. This elite then used its state power to ensure that the nation forgets its radical history which would have alerted future generations to the theft of their inheritance and country. This book provides essential facts about Mau Mau. It seeks to give voice to the Mau Mau resistance fighters. It is aimed at young people who were born after independence and who have been deprived of their historical heritage; it is also a tribute to those who played a part in the war of independence and in Mau Mau without whose contribution independence would have remained a dream. It seeks to restore Kenyas working class history of resistance to colonialism and imperialism. The Kenya Resists Series covers different aspects of resistance by people of Kenya to colonialism and imperialism. It reproduces material from books, unpublished reports, research and oral or visual testimonies. The three aspects chosen for the first three publications in the Series Mau Mau, Trade Unions and Peoples Resistance make up the three pillars of resistance of the people of Kenya.
Temperature- and field-dependent 1H-, 19F-, and 79,81Br-NMR measurements together with zero - field 79,81Br-NQR measurements on polycrystalline samples of barlowite, Cu4(OH)6FBr are conducted to study the magnetism and possible structural distortions on a microscopic level. The temperature dependence of the 79,81Br-NMR spin-lattice relaxation rates 1/T1 indicate a phase transition at TN ≃ 15 K which is of magnetic origin, but with an unusually weak slowing down of fluctuations below TN. Moreover, 1/T1T scales linear with the bulk susceptibility which indicates persisting spin fluctuations down to 2 K. Quadupolare resonance (NQR) studies reveal a pair of zero-field NQR- lines associated with the two isotopes of Br with the nuclear spins of I = 3/2. Quadrupole coupling constants of vQ ≃ 28.5 MHz and 24.7 MHz for 79Br- and 81Br-nuclei are determined from Br-NMR and the asymmetry parameter of the electric field gradient was estimated to η ≃ 0.2. The Br-NQR lines are consistent with our findings from Br-NMR and they are relatively broad, even above TN. This broadening and the relative large η value suggests a symmetry reduction at the Br- site reflecting the presence of a local distortion in the lattice. Our density-functional calculations show that the displacements of Cu2 atoms located between the kagome planes do not account for this relatively large η. On the other hand, full structural relaxation, including the deformation of kagome planes, leads to a better agreement with the experiment.
Ulrich Gerhardt : Nachruf
(2018)
Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson’s disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin ligase Parkin is important to trigger selective autophagy. Although autophagy receptors recruit LC3-labeled autophagic membranes onto damaged mitochondria, how other essential autophagy units such as ATG9A-integrated vesicles are recruited remains unclear. Here, using mammalian cultured cells, we demonstrate that RABGEF1, the upstream factor of the endosomal Rab GTPase cascade, is recruited to damaged mitochondria via ubiquitin binding downstream of Parkin. RABGEF1 directs the downstream Rab proteins, RAB5 and RAB7A, to damaged mitochondria, whose associations are further regulated by mitochondrial Rab-GAPs. Furthermore, depletion of RAB7A inhibited ATG9A vesicle assembly and subsequent encapsulation of the mitochondria by autophagic membranes. These results strongly suggest that endosomal Rab cycles on damaged mitochondria are a crucial regulator of mitophagy through assembling ATG9A vesicles.
The genus Disparalona Fryer, 1968 comprises a well-defined species complex, the hamatagroup, which might have sibling species in South America. This hamata-group needs urgent revision. Besides that, a complete morphological evaluation of the endemic species D. leptorhyncha (Daday, 1905) is lacking. Thus, the aim of the present study is to revise populations of species of the hamatagroup in South America and to redescribe D. leptorhyncha. Our findings pointed to an occurrence of species which are part of the Disparalona (Mixopleuroxus) linage. Currently, the Neotropics have the highest diversity to the genus, with three species of the hamata-complex – D. (M.) hamata (Birge, 1879), D. (M.) lucianae sp. nov., D. (M.) tenuispina sp. nov. – in addition to D. (M.) leptorhyncha. These species can be differentiated from each other by the morphology of their rostrum, labrum, and postabdomen.