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Panel Sample Selection ModelsThe empirical evidence currently available in the literature regarding the effects of a country's IMF program participation on its output growth is rather inconclusive. In this paper we propose and estimate a panel data sample selection model featuring state dependence. As in this model the output growth effects of program participation can be conditional on the realization of a state variable (conditional pooling), our framework may reconcile previous empirical evidence based on models without state-dependent effects. We find that the effects of IMF program participation on output growth vary systematically with an index reflecting a country's institutional record, and that output growth effects of program participation are significantly positive only if the program participation is coupled with sufficient improvement of the institutional record.
Das Forschungsunternehmen "Romanisch und Deutsch am Hinterrhein / GR" von Prof. Dr. Theodor Ebneter (Sprachlabor der Universität Zürich) wurde in den Jahren 1978-1992 am Phonogrammarchiv der Universität Zürich als erstes bilinguistisches Projekt durchgeführt.
Für jede der vier Talschaften des Hinterrheins waren ursprünglich zwei Bände, einer für das Deutsche und einer für das Romanische, vorgesehen. […] Da die Gewährsleute ihre jeweilige Mundart gerne mit jener von Chur vergleichen, wurde die Dissertation von Oscar Eckhardt "Die Mundart der Stadt Chur" (1991)als Band 9 veröffentlicht.
Nachdem Prof. Ebneters Leitung des Phonogrammarchivs 1992 zu Ende ging, konnte mit Unterstützung des Schweizerischen Nationalfonds Band 7 "Romanisch im Boden, in Trin und in Flims" mit seinem Umfang von 622 Seiten abgeschlossen werden, der als romanistische Ergänzung zu Urs Willis 1990 publiziertem Band 8 "Deutsch im Bezirk Imboden " die Untersuchung dieser vierten und letzten Talschaft beschliessen sollte.
Der vorliegende Band 11 der Reihe "Romanisch und Deutsch am Hinterrhein / GR" ersetzt nun Willis Band 8 und schliesst zugleich das Forschungsuntemehmen mit der germanistischen Aufarbeitung des Bodens, von Trins und von Flims ab. Dieser Band wurde von Dr. Alfred Toth und Prof. Dr. Theodor Ebneter parallel zur Herstellung von Band 10 "Die romanisch-deutsche Sprachlandschaft am unteren Hinterrhein" verfasst. Die Ersetzung von Willis Band durch den vorliegenden war auch deshalb nötig, um die die deutschen Mundarten des Bezirks Imboden betreffenden Daten in Band 10 einbauen zu können. Zu diesem Zweck wurden im Winter und Frühling 1994/95 alle Ortschaften des Bezirks Imboden mit 27 Gewährspersonen in längeren Gesprächen aufgenommen.
Band 11 orientiert sich methodisch einerseits an Band 7 über die romanistische Situation des Bezirks Imboden, dessen germanistische Ergänzung er darstellt, anderseits an Band 9 über die Mundart von Chur, der innerhalb der Reihe zum erstenmal vergleichsweise herangezogen werden konnte, nachdem alle übrigen germanistischen Bände früher erschienen waren. Aus diesem Grunde wurde der Einleitung (Kap. 1), der Phonologie (Kap. 2) und der Morphologie (Kap. 3) ein Kapitel 4 "Vergleich der Dialekte des Bezirks Imboden mit der Mundart der Stadt Chur" beigesteIlt, in dem auch Aspekte der Morphosyntax (Kap. 4.3.), der Syntax (Kap. 4.4.) sowie der Lexikologie (Kap. 4.5.) behandelt werden.
Nachdem ich meine Lizentiatsarbeit [..] abgeschlossen hatte, fragte mich Prof. Ebneter an, ob ich bereit wäre, mit dem gleichen Transkritionssystem auch eine Umfrage zu diversen Verbalformen in Graubünden zu erstellen. […] Von Prof. Ebneter bekam ich eine Liste mit den gewünschten Verbformen. Ich habe zu diesen je einen Satz konstruiert, der den Gewährspersonen vorgelegt wurde. Einmal hatten die Informantinnen und Informanten die Verbformen mit vorangestelltem Subjektpronomen und einmal mit Inversion aus der standardsprachliche Vorlage in der 1. Person Singular zu übersetzen. In der Folge habe ich dann das ganze Paradigma abgefragt.
Die Resultate meiner Erhebung sind teilweise in die Verbalmorphologie des Abschlussbandes zum Forschungsprojekt "Deutsch und Romanisch am Hinterrhein" eingeflossen. Insgesamt aber sind die Verbformen noch nie integral veröffentlicht worden. Eine eigenständige gedruckte Publikation verlangte wohl auch einen Kommentar zu den Paradigmen. Mit der Möglichkeit, Texte auch digital zu publizieren, hat sich allerdings eine neue Verbreitungsform ergeben, die es erlaubt, auch "Materialien" zu veröffentlichen, die vielleicht anderen wissenschaftlich Arbeitenden nützlich sein können. Im Zeichen des zum Teil rapiden Sprachwandels gerade in der Verbalmorphologie stellen die 1988 erfassten Verbparadigmen aber auch ein Brückendokument dar, das spannende Vergleiche zwischen den Aussagen früherer Forschungen und aktuellen Daten zulässt.
Although oil price shocks have long been viewed as one of the leading candidates for explaining U.S. recessions, surprisingly little is known about the extent to which oil price shocks explain recessions. We provide the first formal analysis of this question with special attention to the possible role of net oil price increases in amplifying the transmission of oil price shocks. We quantify the conditional recessionary effect of oil price shocks in the net oil price increase model for all episodes of net oil price increases since the mid-1970s. Compared to the linear model, the cumulative effect of oil price shocks over course of the next two years is much larger in the net oil price increase model. For example, oil price shocks explain a 3% cumulative reduction in U.S. real GDP in the late 1970s and early 1980s and a 5% cumulative reduction during the financial crisis. An obvious concern is that some of these estimates are an artifact of net oil price increases being correlated with other variables that explain recessions. We show that the explanatory power of oil price shocks largely persists even after augmenting the nonlinear model with a measure of credit supply conditions, of the monetary policy stance and of consumer confidence. There is evidence, however, that the conditional fit of the net oil price increase model is worse on average than the fit of the corresponding linear model, suggesting much smaller cumulative effects of oil price shocks for these episodes of at most 1%.
Efforts to control bank risk address the wrong problem in the wrong way. They presume that the financial crisis was caused by CEOs who failed to supervise risk-taking employees. The responses focus on executive pay, believing that executives will bring non-executives into line—using incentives to manage risk-taking—once their own pay is regulated. What they overlook is the effect on non-executive pay of the competition for talent. Even if executive pay is regulated, and executives act in the bank’s best interests, they will still be trapped into providing incentives that encourage risk-taking by non-executives due to the negative externality that arises from that competition. Greater risk-taking can increase short-term profits and, in turn, the amount a non-executive receives, potentially at the expense of long-term bank value. Non-executives, therefore, have an incentive to incur significant risk upfront so long as they can depart for a new employer before any losses materialize. The result is an upward spiral in compensation—reducing an executive’s ability to set non-executive pay and the ability of any one bank to adjust compensation to reflect risk-taking and long-term outcomes. New regulation must address the tension between compensation and competition. Regulators should take account of the effect of competition on market-wide levels of pay, including by non-banks who compete for talent. The ability of non-executives to jump from a bank employer to another financial firm should also be limited. In addition, banks should be required to include a long-term equity component in non-executive pay, with subsequent employers being restricted from compensating a new employee for any losses she incurs related to her prior work.
We examine trust and trustworthiness of individuals with varying professional preferences and experiences. Our subjects study business and economics in Frankfurt, the financial center of Germany and continental Europe. In the trust game, subjects with a high interest in working in the financial industry return 25 percent less than subjects with a low interest. We find no evidence that the extent of professional experience in the financial industry has a negative impact on trustworthiness. We also do not find any evidence that the financial industry screens out less trustworthy individuals in the hiring process. In a prediction game that is strategically equivalent to the trust game, the amount sent by first-movers was significantly smaller when the second-mover indicated a high interest in working in finance. These results suggest that the financial industry attracts less trustworthy individuals, which may contribute to the current lack of trust in its employees.
In the wake of the Global Financial Crisis that started in 2007, policymakers were forced to respond quickly and forcefully to a recession caused not by short-term factors, but rather by an over-accumulation of debt by sovereigns, banks, and households: a so-called “balance sheet recession.” Though the nature of the crisis was understood relatively early on, policy prescriptions for how to deal with its consequences have continued to diverge. This paper gives a short overview of the prescriptions, the remaining challenges and key lessons for monetary policy.
n a contribution prepared for the Athens Symposium on “Banking Union, Monetary Policy and Economic Growth”, Otmar Issing describes forward guidance by central banks as the culmination of the idea of guiding expectations by pure communication. In practice, he argues, forward guidance has proved a misguided idea. What is presented as state of the art monetary policy is an example of pretence of knowledge. Forward guidance tries to give the impression of a kind of rule-based monetary policy. De facto, however, it is an overambitious discretionary approach which, to be successful, would need much more (or rather better) information than is currently available. In Issing's view, communication must be clear and honest about the limits of monetary policy in a world of uncertainty.
Die „Rente mit 63“ hat wieder einmal den Blick auf den Renteneintritt gerichtet. In der öffentlichen Debatte werden dabei zwei Ereignisse regelmäßig vermischt: das Ende des Arbeitslebens und der Beginn der Rentenzahlung. Dabei müssen beide nicht unmittelbar aufeinander folgen. Unter bestimmten Umständen kann es finanziell attraktiv sein, die staatliche Rente nicht sofort nach dem Ausstieg aus dem Erwerbsleben zu beantragen, sondern die Ausgaben bis zum späteren Rentenbeginn durch den Abbau von Finanzkapital zu finanzieren. Dieser Beitrag gibt einen kurzen Einblick in die neueste Studie von Olivia Mitchell, Andreas Hubener und Raimund Maurer zur Alterssicherung in den USA und stellt auch Berechnungen für Deutschland auf.
Jubiläen drängen zur Standortbestimmung. Im Jahr 2014 feiert die Frankfurter Goethe Universität ihren 100. Geburtstag. Man lud zu Bilanzen ein, zum Blick nach vorn, auf Erfahrungen und Erwartungen der Rechtswissenschaft und ihrer Teildisziplinen. In diese Spannung stellt sich auch dieser Beitrag zu den Perspektiven des Fachs ‚Rechtsgeschichte‘. Es wird deswegen nur kurz um 100 Jahre (I.), wenig um die Zeit nach 1945 (II.), weit mehr um Rahmenbedingungen rechtshistorischen Forschens in der ‚Berliner Republik‘ (III.) – und um Zukunftsperspektiven des Fachs gehen (IV.).
Results of an Odonata survey carried out in the peatlands of Central Kalimantan, Indonesia, in 2012
(2014)
The results of a survey of Odonata (dragonflies and damselflies) in the peat lands of Central Kalimantan, Indonesia, in 2012 are presented. Fifty four species of Odonata found in the area in June-July 2012 are listed, along with brief notes and the locations in which they were found. Of the species found, twelve had not been recorded in Central Kalimantan previously, and of these at least four are completely new to science. Six species, originally described from Central Kalimantan and not recorded any- where since 1953, were rediscovered. At least sixteen of the species found during the survey are considered to be of conservation concern. The discovery of at least four new species to science in a relatively short survey indicates a high probability of occurrence of many more species that are awaiting discovery, and that many un-discovered species may be lost or highly threatened because of the rapid demise of peat swamp forest habitats. A checklist of the Odonata known from Central Kalimantan is provided in an appendix.
The human endothelin receptors, ETA and ETB, are two members of the G-protein coupled receptors family (GPCRs) and they are key players in cardiovascular regulation. The characterization of their functionality in vitro has been limited by the possibility to obtain high quality samples using conventional expression systems. The Cell-Free expression system is an alternative technique for the production of membrane protein as well as GPCRs and can overcome some of the limitations that are commonly encountered using an in vivo approach. Cell-Free expression protocols for the two receptors ETA and ETB have been optimized by implementing post- and co-translational association to lipid bilayers. The efficiency of the reconstitution or association to liposomes and nanodiscs has systematically been studied and the ligand binding properties of the two receptors have been analyzed using a set of different complementary techniques. In several different conditions a high affinity binding of the peptide ligand ET-1 to both endothelin receptors could be obtained and the highest activity values were detected in sample prepared using a co-translational approach in presence of nanodiscs. Furthermore, the characteristic differential binding pattern of selected agonists and antagonists to the two receptors was confirmed. In samples obtained from several Cell-Free expression conditions, two intrinsic properties of the functionally folded ETB receptor, such as the proteolytic processing based on conformational recognition as well as the formation of SDS-resistant complexes with the peptide ligand ET-1, were detected. ETA and ETB are able to induce in vivo the activation of hetrotrimeric G proteins upon stimulation with an agonist, leading to the dissociation of the heterotrimeric complex and the exchange of GDP to GTP in the Galpha subunit. The Cell-Free expression system was chosen for the production of two G alpha subunit, Galpha s and Galpha q. Soluble expression of the two proteins was achieved and the production of active Galpha s was confirmed using fluorescent as well as radioactive assays. In conclusion, the obtained results document a new process for the production of ligand binding competent endothelin receptors, as well as Galpha proteins, using a Cell-Free expression system. The combination of this expression system and the nanodiscs technology appears to be a promising tool for the further characterization of membrane proteins as well as GPCRs.
We investigate the relationship between anchoring and the emergence of bubbles in experimental asset markets. We show that setting a visual anchor at the fundamental value (FV) in the first period only is sufficient to eliminate or to significantly reduce bubbles in laboratory asset markets. If no FV-anchor is set, bubble-crash patterns emerge. Our results indicate that bubbles in laboratory environments are primarily sparked in the first period. If prices are initiated around the FV, they stay close to the FV over the entire trading horizon. Our insights can be related to initial public offerings and the interaction between prices set on pre-opening markets and subsequent intra-day price dynamics.
he observed hump-shaped life-cycle pattern in individuals' consumption cannot be explained by the classical consumption-savings model. We explicitly solve a model with utility of both consumption and leisure and with educational decisions affecting future wages. We show optimal consumption is hump shaped and determine the peak age. The hump results from consumption and leisure being substitutes and from the implicit price of leisure being decreasing over time; more leisure means less education, which lowers future wages, and the present value of foregone wages decreases with age. Consumption is hump shaped whether the wage is hump shaped or increasing over life.
This paper provides a systematic analysis of individual attitudes towards ambiguity, based on laboratory experiments. The design of the analysis allows to capture individual behavior across various levels of ambiguity, ranging from low to high. Attitudes towards risk and attitudes towards ambiguity are disentangled, providing pure measures of ambiguity aversion. Ambiguity aversion is captured in several ways, i.e. as a discount factor net of a risk premium, and as an estimated parameter in a generalized utility function. We find that ambiguity aversion varies across individuals, and with the level of ambiguity, being most prominent for intermediate levels. Around one third of subjects show no aversion, one third show maximum aversion, and one third show intermediate levels of ambiguity aversion, while there is almost no ambiguity seeking. While most theoretical work on ambiguity builds on maxmin expected utility, our results provide evidence that MEU does not adequately capture individual attitudes towards ambiguity for the majority of individuals. Instead, our results support models that allow for intermediate levels of ambiguity aversion. Moreover, we find risk aversion to be statistically unrelated to ambiguity aversion on average. Taken together, the results support the view that ambiguity is an important and distinct argument in decision making under uncertainty.
Paul Tillich wurde 1929 nach Frankfurt/M., wo es damals noch keine Theologische Fakultät gab, auf den Lehrstuhl für Philosophie mit der Verpflichtung berufen, „Philosophie und die Soziologie einschließlich Sozialpädagogik“ zu vertreten. Der ordinierte Pfarrer verstand die Konzentration auf die Philosophie gerade nicht als Absage an die Theologie; er sah sich immer als ein Grenzgänger, ohne Überläufer zu werden. Was seine Verbindung zur „Frankfurter Schule“ anbelangt, so wurde der Jude Theodor Wiesengrund Adorno von Tillich habilitiert; mit Max Horkheimer veranstaltete er Seminare. Während seiner Frankfurter Zeit hat sich Tillich z. B. dem Verhältnis von Protestantismus und Profanität zugewandt: „Das Heilige liegt nicht außerhalb des Profanen, sondern in seiner Tiefe. Es ist der schöpferische Grund des Profanen“; Kultur ist ihrer Substanz nach Religion. 1929 schloß sich Tillich der SPD an, aus der er 1933 austrat. Dennoch mußte er am 10.5.1933 mit ansehen, wie auf dem Frankfurter Römer auch ein Exemplar seines Buches „Die sozialistische Entscheidung“ verbrannt wurde. Zusammen mit Max Horkheimer wurde Tillich am 13.4.1933 „beurlaubt“ und am 20.12.1933 aus dem Staatsdienst entlassen. Er emigrierte in die USA, wo er 1965 starb.
Auch den großen katholischen Theologen Karl Rahner SJ, der sich 1937 in Innsbruck für katholische Dogmatik habilitierte, zeichnet eine ähnliche Breite des Wissens und Denkens aus. 1964 erhielt er den „Prestigelehrstuhl“ Romano Guardinis (Lehrstuhl für christliche Weltanschauung) in München. Seine akademische Lehrtätigkeit und sein Wirken als Konzilstheologe machten ihn schon in jungen Jahren weit über Deutschland und Europa hinaus bekannt.
Ich beginne mit einer etwas vereinfachten Darstellung der sogenannten 'Letzten Dinge' (Eschata) in der traditionellen (neu)scholastischen Theologie (Vgl. Siegfried Meier, Sterben, Tod und Auferstehung, in: Schulinformationen, Paderborn, 30. Jg., Nr. 2, 2000, S. 61ff.). Diese geht davon aus, daß sich im Tod die unsterbliche Seele vom sterblichen Leib trennt. Der Leichnam verfällt, die Seele hingegen kommt ganz allein vor das Gericht Gottes. Daher nennt man dieses Gericht auch das besondere Gericht (iudicium particulare). Derjenige, der im Zustand der Heiligkeit verstorben ist und alle zeitlichen Sündenstrafen schon in diesem Leben abgebüßt hat, dessen Seele kommt sofort in den Himmel. Stirbt hingegen ein Mensch im Zustand der Todsünde, beginnt durch den Richterspruch Gottes die sofortige Verdammnis in der Hölle. Der mittelmäßige Mensch, der weder als Heiliger noch als Todsünder gestorben ist, muß eine Zeit der Läuterungsqualen im Fegefeuer erleiden. Schwere und Menge der noch nicht abgebüßten Sündenstrafen bestimmen die Dauer und Intensität des dortigen Aufenthaltes. Erst danach kann die Seele in den Himmel gelangen. Am letzten Tag der Weltgeschichte, dem sogenannten 'Jüngsten Tag', kommt es zur Auferstehung der Toten. Das bedeutet, daß die Seelen mit dem toten Körper wieder zu lebendigen Menschen vereinigt werden. Dann wird Gericht gehalten über den ganzen Menschen. Dieses Gericht wird daher als das allgemeine Gericht (iudicium universale) bezeichnet. Nach diesem Gericht gibt es nur noch Himmel und Hölle.
Was das Fegefeuer und den damit verbundenen Ablaß anbelangt, so haben sich die Reformatoren mit diesem Bild von Tod und Auferstehung kritisch auseinandergesetzt, was aber Gemeinsamkeiten, die auch im Blick auf gemeinsames Erbe antiker Philosophie begründet sind, nicht ausschließt...
Jubiläen haben es in sich! In diesem Jahr werden wir vor allem an den großen Philosophen Immanuel Kant erinnert, der am 12.2.1804 in Königsberg in Preußen gestorben ist. Sein Denkmal am Königsberger Dom hat den Krieg und auch die Russen überstanden. Am populärsten ist bis heute Kants Erläuterung von „Aufklärung“: „Aufklärung ist der Ausgang des Menschen aus seiner selbst verschuldeten Unmündigkeit. Unmündigkeit ist das Unvermögen, sich seines Verstandes ohne Leitung eines anderen zu bedienen. Sapere aude! Habe Mut, dich deines eigenen Verstandes zu bedienen! ist also der Wahlspruch der Aufklärung!“1 Nicht nur, daß die 1784 niedergeschriebene Abhandlung Kants nicht am Anfang der deutschen Aufklärung steht, sondern eher ihr Schwanengesang ist: In der Regel wird auch verschwiegen, daß der Autor selbst die prinzipielle Gültigkeit dieser Sätze entscheidend einschränkte, wenn er am Schluß seiner Abhandlung alle radikalen Konsequenzen ausdrücklich verwarf und das Grundgesetz des friderizianischen Preußen pries: „Räsonniert, soviel als ihr wollt, und worüber ihr wollt, nur gehorcht!“ Kant hat den Angriff Napoleons auf Europa, den Zusammenbruch Preußens und Österreichs nicht mehr erlebt. So ist ihm die bittere Erfahrung erspart geblieben, daß von den Idealen einer Revolution meistens nur verwirklicht wird, was machtpolitisch brauchbar ist...
Anonyme Protestanten?
(2014)
Selbst bei theologisch so verschiedenen Charakteren wie Dorothee Sölle und Paul Tillich wurden religionskulturelle Unterschiede zwischen Personen durch den Verweis auf Gemeinsamkeiten in ihrem Leben und Handeln als „anonyme Christen“ zumindest relativiert, wenn nicht gar durch diese umfassende Kategorie ganz eingezogen. Differenzen zwischen Selbsteinschätzung und Fremdwahrnehmung der betreffenden Personen spielen dann kaum noch eine wesentliche Rolle.
Im Rückblick auf zwei Jubiläen soll im Folgenden die Brauchbarkeit der Kategorie „Anonyme Christen“ am Sonderfall „Anonyme Protestanten“ überprüft werden.
Der Titel bedarf einer besonderen Begründung! 800 Jahre Elisabeth von Thüringen: Katholische und Evangelische Kirche begehen z. B. in Hessen mit einer Fülle von Veranstaltungen 2007 das „Elisabethjahr“. Die Ev. Kirche in Kurhessen-Waldeck und die Ev. Kirche in Hessen und Nassau haben unter dem Titel „Krone, Brot und Rosen. 800 Jahre Elisabeth von Thüringen“ einen umfangreichen Veranstaltungskalender vorgelegt. Bereits an ihrem 775. Todestag lassen die hessischen Landeskirchen und Bistümer in ökumenischer Eintracht, aber mit unterschiedlicher Akzentuierung das Elisabethjahr beginnen. „In einem war man sich schnell einig: Elisabeth kann sicher nicht als moderne Sozialapostolin gedeutet werden, die auf die reine Mitmenschlichkeit setzte; dafür waren ihre Christusfrömmigkeit und ihre Christusnachfolge zu stark ausgeprägt; sie verband praktizierte Caritas mit tiefer Gottesbeziehung. Es gab aber ein hartes Ringen um ein gemeinsames Erscheinungsbild des Gedenkens. Das Attribut ‚heilig‘ war für die evangelische Seite nicht akzeptabel. Für Protestanten ist die fürstliche Wohltäterin nur Elisabeth von Thüringen, und so steht es auch auf dem Logo für evangelische Gedenkveranstaltungen. Auf dem Logo für ökumenisch verantwortete Veranstaltungen wird kompromißhaft zusammengefügt: ‚Heilige Elisabeth. Elisabeth von Thüringen‘ “ (Gernot Facius). Wenn ich im Folgenden weiter von der „Hl. Elisabeth“ rede, soll dieser Hintergrund nicht vergessen werden.
Spuren der Elisabeth-Verehrung finden sich aber nicht nur in Deutschland und in Ungarn. Auch in Italien, Portugal, Tschechien, ja sogar in Skandinavien und den baltischen Ländern erinnert man sich an die deutsche Nationalheilige des Mittelalters...
"Du sollst dir kein Bildnis noch irgendein Gleichnis machen, weder des, das oben im Himmel, noch des, das unten auf Erden, oder des, das im Wasser unter der Erde ist" (Exodus 20,4): Dieses Gebot aus dem Dekalog hat die Religions- und Kulturgeschichte immer wieder berührt. Vor allem der reformierte Protestantismus rühmt sich seiner 'Bilderlosigkeit'. Was sind aber 'Bilder'? ...
Mohammad Arkoun (٭1928, Algeria; †2010, Paris) was an influential Muslim intellectual and particularly concerned with - amongst a profound spectrum of scholarly interests – reforming the academic study of Islamic societies. Trained at the University of Algiers (Faculty of Philology) he ventured off to lecture Arab language and literature at the Sorbonne. His engagement with philosophy and sociology led in 1968 to his PhD at the Sorbonne through a work on Ibn Miskawayh’s ethics...
This exploration into Arkoun’s stances on the Quran looks onto the genesis of the Quran, the notion of the Quran as the ‘deliverer of truth’, and with that, its significane for the ‘being in the world’ of Muslim societies. I will also point out some crucial difficulties in the study of Arkoun’s views on the Quran as well as their implications for the study of Islamic cultures.
The Crusade movement is one of the most important occurrences of medieval history. It took place throughout two centuries in the Levant and affected both Muslims and Crusaders and in turn changed the way in which West and East related to one another. When the Crusaders took control of the Holy Land and many Islamic cities in the Levant, they transferred their feudal European system there. They established four main fiefdoms or lordships, Jerusalem, Edessa, Antioch and Tripoli. In addition, there were another twelve secondary fiefdoms, of which Tibnīn was one. Tibnīn was called “Toron” by the Crusaders. Once the Crusaders had captured Tibnīn, they began building its fortified castle, from which the fief of Tibnīn gained its importance throughout the period of the Crusades.
This paper traces the military role of Tibnīn and its rulers in the Latin East against the Muslims until 1187/ 583. Tibnīn played a key role in overcoming the Muslims in Tyre and controlled it in 1124. It also played a vital role in the conflict between Damascus and the Kingdom of Jerusalem. Tibnīn participated in defending Antioch, Banyas, Hebron and Transjordan several times. Furthermore, its soldiers and Knights joined the army of the Kingdom of Jerusalem to capture Ascalon in 1153, and joined the campaigns of Amaury I, King of Jerusalem, against Egypt from 1164 to1169. The military situation of Tibnīn under the rule of the royal house until its fall to the Muslims in 1187/ 583 will be studied as well.
The Crusade movement is one of the most important occurrences of medieval history. It took place throughout two centuries in the Levant and affected both Muslims and Crusaders and in turn changed the way in which West and East related to one another.1 When the Crusaders took control of the Holy Land and many Islamic cities in the Levant, they transferred their feudal European system there. They established four main fiefdoms or lordships, Jerusalem, Edessa, Antioch and Tripoli. In addition, there were another twelve secondary fiefdoms,2 of which Tibnīn was one. Tibnīn was called “Toron” by the Crusaders. Once the Crusaders had captured Tibnīn, they began building its fortified castle, from which the fief of Tibnīn gained its importance throughout the period of the Crusades.
This paper traces the military role of Tibnīn and its rulers in the Latin East against the Muslims until 1187/ 583. Tibnīn played a key role in overcoming the Muslims in Tyre and controlled it in 1124. It also played a vital role in the conflict between Damascus and the Kingdom of Jerusalem. Tibnīn participated in defending Antioch, Banyas, Hebron and Transjordan several times. Furthermore, its soldiers and Knights joined the army of the Kingdom of Jerusalem to capture Ascalon in 1153, and joined the campaigns of Amaury I, King of Jerusalem, against Egypt from 1164 to1169. The military situation of Tibnīn under the rule of the royal house until its fall to the Muslims in 1187/ 583 will be studied as well.
In this essay, one of the most serious problems highlighted with respect to contemporary Iranians, who are mostly known as Shi‘ite-Perso (Shi‘ite-Persian) citizens of Iran, and what their view toward abusing wine and opium is. On one hand, the wealthy Persian literature is full of poems, narrations and notes with reference to wine and opium, while on the other hand, many parts of Shi‘ite-Islamic thought deem wine unclean and illegal, and abusing opium is forbidden except under certain [hard-fulfilling] conditions. Hereby, in this essay the aim is to express why the question “are drinking wine and abusing opium known as addiction or literal culture?” is suspended throughout the young Iranian generation. In this regard, the standpoints of Persian poets and Iranian religious figures towards wine and opium will be considered.
Motivated by the question whether sound and expressive applicative similarities for program calculi with should-convergence exist, this paper investigates expressive applicative similarities for the untyped call-by-value lambda-calculus extended with McCarthy's ambiguous choice operator amb. Soundness of the applicative similarities w.r.t. contextual equivalence based on may-and should-convergence is proved by adapting Howe's method to should-convergence. As usual for nondeterministic calculi, similarity is not complete w.r.t. contextual equivalence which requires a rather complex counter example as a witness. Also the call-by-value lambda-calculus with the weaker nondeterministic construct erratic choice is analyzed and sound applicative similarities are provided. This justifies the expectation that also for more expressive and call-by-need higher-order calculi there are sound and powerful similarities for should-convergence.
The pi-calculus is a well-analyzed model for mobile processes and mobile computations.
While a lot of other process and lambda calculi that are core languages of higher-order concurrent and/or functional programming languages use a contextual semantics observing the termination behavior of programs in all program contexts, traditional program equivalences in the pi-calculus are bisimulations and barbed testing equivalences, which observe the communication capabilities of processes under reduction and in contexts.
There is a distance between these two approaches to program equivalence which makes it hard to compare the pi-calculus with other languages. In this paper we contribute to bridging this gap by investigating a contextual semantics of the synchronous pi-calculus with replication and without sums.
To transfer contextual equivalence to the pi-calculus we add a process Stop as constant which indicates success and is used as the base to define and analyze the contextual equivalence which observes may- and should-convergence of processes.
We show as a main result that contextual equivalence in the pi-calculus with Stop conservatively extends barbed testing equivalence in the (Stop-free) pi-calculus. This implies that results on contextual equivalence can be directly transferred to the (Stop-free) pi-calculus with barbed testing equivalence.
We analyze the contextual ordering, prove some nontrivial process equivalences, and provide proof tools for showing contextual equivalences. Among them are a context lemma, and new notions of sound applicative similarities for may- and should-convergence.
The Paddys River Wetlands in the New South Wales Southern Highlands, southwest of Sydney, are characterised by several watercourses with associated swamps (fens), some of which, on Forestry Corporation of NSW land, have been the focus for removal of Pinus radiata wildings by the Penrose Swamps Conservation Group. In this study we map a population of Eucalyptus aquatica trees in one of these swamps perched above Paddys River (latitude 34.65575o S, longitude 150.21831o E; 600 m elevation). Eucalyptus aquatica is geographically restricted to the Paddys River area and is listed as a threatened species at state and national levels. New findings on the physical characteristics of the swamp in relation to the bedrock geology, stream geomorphology, peat development and the main native plant species, are presented. The occurrence of clumps of Eucalyptus aquatica appears to be independent of the type or thickness of the growing substrate. Rather it is suggested that a continuous supply of water and the shelter afforded by the narrow valley may be key factors determining the distribution of the trees at the study site. An on-going programme of research is underway to study other occurrences of Eucalyptus aquatica.
The Queensland Herbarium Regional Ecosystem Survey and Mapping (QHRESM) program has contributed almost 90000 (89389) specimens to the Queensland Herbarium in Brisbane accounting for 28% of the specimens added to the Herbarium between 1970 and 2011. These specimens have been collected across all bioregions and vegetation communities in Queensland in a systematic sampling program driven by the requirement to sample comprehensively all vegetation communities. The QHRESM’s Queensland Herbarium (BRI) specimens represent more than 79% of the native, and 73% of the naturalised vascular flora of Queensland, as well as making valuable contributions to the bryophytes, lichens and liverworts collections. The data and specimens collected enhance our ability to assess local, state and continental-scale plant diversity, and will be used by botanists, ecologists, governments, business and the public for long into the future.
Natural vegetation of freely draining beach sand ridges in the valley of the Upper Myall River on the lower North Coast of NSW is sclerophyllous open forest or woodland. Based on previous experience on the nearby Eurunderee area, the vegetation on the sand ridges was classified into three types. These were mapped using aerial photographs and field observation. In transects, each 50 m long, the presence of species was scored in 10, 5 X 5 m quadrats. 48 such transects were used sampling all three types of vegetation on the sand ridges and also vegetation in periodically waterlogged sites adjacent to the ridges. Data from the transects, subjected to an ordination using principal components analysis, revealed clear separation between vegetation of the ridges and that of periodically waterlogged sites. In the ordination, vegetation of the ridges formed a continuum with the three types occupying characteristic parts of the continuum, reflecting their respective distributions on sands with different geomorphological histories. The most grassy, tallest forest, termed Dry Sclerophyll Forest (DSF) is on sands either recently disturbed or deposited (Holocene) or closely overlying other substrates. Banksia serrata occurs in DSF. The least grassy, most sclerophyllous, lowest forest or woodland, termed Dry Heath Forest (DHF), occurs on sands apparently little disturbed since they were laid down in the Pleistocene. Banksia aemula occurs in DHF. An intermediate forest, in which Banksia aemula and Banksia serrata occur together, Intermediate Dry Forest (IDF), is most widely found on the sand mass close to Bombah Broadwater. This sand is postulated to have been reworked during the last Glacial Period. In short, the vegetation of these sand ridges largely varies with time since they were laid down or last disturbed in a major way. Preliminary observations indicate the degree of podsolization of their soils is similarly related to this variation in time.
Lysimachia mauritiana Lam. (family Primulaceae), a small short-lived herb native to India, Indian and Pacific Ocean islands, and coastal east Asia, is described as a new naturalised record from the eastern suburbs of Sydney, New South Wales, Australia. It was first recorded in 1981 near Coogee, and grows in exposed rock crevices and seepages on the seacoast, very similar to its natural habitat overseas. Lysimachia mauritiana is known to have been cultivated in the area in 1961 in a home garden, which is the likely source of this introduction; it appears to be spreading locally as a weed.
Vegetation of Little Bora Nature Conservation Trust Agreement, North Western Slopes, New South Wales
(2014)
The vegetation of the Little Bora Nature Conservation Trust Agreement property (560 ha in area), 8 km south east of Bingara (lat 29° 55’S long 150° 37’) in the Gwydir Shire and within the Nandewar Bioregion is described. Eight vegetation communities are defined based on flexible UPGMA analysis of cover-abundance scores of all vascular plant taxa. These communities are mapped based on ground truthing, ADS40 imagery interpretation, topography and substrate. Communities described are: 1) Melaleuca bracteata – Eucalyptus melanophloia – Eucalyptus camaldulensis Woodland, 2) Callitris glaucophylla – Eucalyptus melanophloia – Eucalyptus albens Woodland, 3) Callitris glaucophylla – Eucalyptus melanophloia – Brachychiton populneus Woodland, 4) Eucalyptus albens Woodland, 5) Eucalyptus caleyi – Eucalyptus albens – Callitris glaucophylla Woodland, 6) Callitris glaucophylla – Eucalyptus melanophloia – Eucalyptus albens Woodland, 7) Austrostipa verticillata – Austrostipa scabra Derived Grassland, 8) Eucalyptus melliodora – Eucalyptus dealbata Woodland. A total of 232 vascular plant taxa were found of which 14% were considered exotic in origin. 66 ha of listed threatened communities were mapped along with populations of a currently listed Extinct plant (TSC Act) Dodonaea stenophylla.
A population of 700 Blandfordia cunninghamii Lindl. (family Blandfordiaceae) plants in the Blue Mountains, 100 km west of Sydney, New South Wales was monitored over a period of seven years, during which a part of the population area was burnt in a Hazard Reduction Burn (HRB). The survey measured flowering of Blandfordia cunninghamii in both the burnt and unburnt areas. In part of the unburnt area flowering (in December) was strongly correlated with previous September rainfall, but in another unburnt area there was no flowering at all over the seven years. An enhanced flowering response after fire was found in the burnt area and the diminution of this enhanced response in subsequent years was found to be logarithmic (taking into account potential rainfall effects). No recruitment of juvenile plants after fire was observed. 87% of seeds of Blandfordia cunninghamii were found to be germinable. Slow juvenile growth of Blandfordia cunninghamii in the field was measured over seven years. Seed was collected for two major seedbanks, the NSW Plantbank at the Australian Botanic Garden, Mt Annan and the Millennium Seedbank at Kew in the United Kingdom.
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
Der vollständige Titel der vorliegenden Arbeit lautet: Sprachwandel in Chur: 'Aufnahmen des Sprachatlasses der deutschen Schweiz (SDS) konfrontiert mit der Mundart von heute'. Entsprechend dieses Programmes sollen folgende Fragen beantwortet werden:
o Was für Aenderungen können wir in der Churer Mundart ausmachen?
o In welche Richtung gehen diese Aenderungen? Lassen sich Tendenzen ausmachen?
o Welche Einflüsse führten zu den festgestellten Veränderungen?
Es ist klar, dass im Rahmen dieser Arbeit nur ein Teil allen Sprachwandels in Chur festgehalten werden konnte. Es ist aber durchaus möglich, anhand der erfassen Veränderungen Schlüsse zu ziehen, die sich auch auf die Mundart von Chur überhaupt übertragen lassen.
Schwerpunktmässig wurden für diese Arbeit Vokalismus und morphologisch-syntaktische Probleme bevorzugt behandelt. Für Konsonantismus eignet sich die Form der schriftlichen Umfrage wenig (Vgl. Kap.l.3.). Der Wandel im mundartlichen Wortschatz ist zu gross, als dass er auch nur annähernd vollständig behandelt werden könnte. Und Stiefkinder mussten auch satzmelodische und rhythmische Probleme bleiben. Dafür wurden anhand ausgesuchter Beispiele Phänomene erfasst, bei welchen der SDS nicht als Grundlage dienen konnte.
Wichtig ist für diese Arbeit, dass mit "der Mundart von heute" auch wirklich heutige Mundart erfasst wurde. Es sollte also keineswegs eine "richtige" Churer Mundart rekonstruiert (auch wenn dies mit den Verweisen auf die SDS-Karten implizit natürlich gemacht worden ist), sondern vielmehr mit den Aussagen der Gewährspersonen (Gwp) gearbeitet werden. In diesem Sinne kann Sekundärliteratur Erhellung bringen, soll aber nicht Untersuchungsgegenstand sein.
SAFE Newsletter : 2014, Q2
(2014)
Many studies about endocrine pollution in the aquatic environment reveal changes in the reproduction system of biota. We analysed endocrine activities in two rivers in Southern Germany using three approaches: (1) chemical analyses, (2) in vitro bioassays, and (3) in vivo investigations in fish and snails. Chemical analyses were based on gas chromatography coupled with mass spectrometry. For in vitro analyses of endocrine potentials in water, sediment, and waste water samples, we used the E-screen assay (human breast cancer cells MCF-7) and reporter gene assays (human cell line HeLa-9903 and MDA-kb2). In addition, we performed reproduction tests with the freshwater mudsnail Potamopyrgus antipodarum to analyse water and sediment samples. We exposed juvenile brown trout (Salmo trutta f. fario) to water downstream of a wastewater outfall (Schussen River) or to water from a reference site (Argen River) to investigate the vitellogenin production. Furthermore, two feral fish species, chub (Leuciscus cephalus) and spirlin (Alburnoides bipunctatus), were caught in both rivers to determine their gonadal maturity and the gonadosomatic index. Chemical analyses provided only little information about endocrine active substances, whereas the in vitro assays revealed endocrine potentials in most of the samples. In addition to endocrine potentials, we also observed toxic potentials (E-screen/reproduction test) in waste water samples, which could interfere with and camouflage endocrine effects. The results of our in vivo tests were mostly in line with the results of the in vitro assays and revealed a consistent reproduction-disrupting (reproduction tests) and an occasional endocrine action (vitellogenin levels) in both investigated rivers, with more pronounced effects for the Schussen river (e.g. a lower gonadosomatic index). We were able to show that biological in vitro assays for endocrine potentials in natural stream water reasonably reflect reproduction and endocrine disruption observed in snails and field-exposed fish, respectively.
We study consumption-portfolio and asset pricing frameworks with recursive preferences and unspanned risk. We show that in both cases, portfolio choice and asset pricing, the value function of the investor/representative agent can be characterized by a specific semilinear partial differential equation. To date, the solution to this equation has mostly been approximated by Campbell-Shiller techniques, without addressing general issues of existence and uniqueness. We develop a novel approach that rigorously constructs the solution by a fixed point argument. We prove that under regularity conditions a solution exists and establish a fast and accurate numerical method to solve consumption-portfolio and asset pricing problems with recursive preferences and unspanned risk. Our setting is not restricted to affine asset price dynamics. Numerical examples illustrate our approach.
We study self- and cross-excitation of shocks in the Eurozone sovereign CDS market. We adopt a multivariate setting with credit default intensities driven by mutually exciting jump processes, to capture the salient features observed in the data, in particular, the clustering of high default probabilities both in time (over days) and in space (across countries). The feedback between jump events and the intensity of these jumps is the key element of the model. We derive closed-form formulae for CDS prices, and estimate the model by matching theoretical prices to their empirical counterparts. We find evidence of self-excitation and asymmetric cross-excitation. Using impulse-response analysis, we assess the impact of shocks and a potential policy intervention not just on a single country under scrutiny but also, through the effect on cross-excitation risk which generates systemic sovereign risk, on other interconnected countries.
Exit strategies
(2014)
We study alternative scenarios for exiting the post-crisis fiscal and monetary accommodation using a macromodel where banks choose their capital structure and are subject to runs. Under a Taylor rule, the post-crisis interest rate hits the zero lower bound (ZLB) and remains there for several years. In that condition, pre-announced and fast fiscal consolidations dominate - based on output and inflation performance and bank stability - alternative strategies incorporating various degrees of gradualism and surprise. We also examine an alternative monetary strategy in which the interest rate does not reach the ZLB; the benefits from fiscal consolidation persist, but are more nuanced.
We study the behavioral underpinnings of adopting cash versus electronic payments in retail transactions. A novel theoretical and experimental framework is developed to primarily assess the impact of sellers’ service fees and buyers’ rewards from using electronic payments. Buyers and sellers face a coordination problem, independently choosing a payment method before trading. In the experiment, sellers readily adopt electronic payments but buyers do not. Eliminating service fees or introducing rewards significantly boosts the adoption of electronic payments. Hence, buyers’ incentives play a pivotal role in the diffusion of electronic payments but monetary incentives cannot fully explain their adoption choices. Findings from this experiment complement empirical findings based on surveys and field data.
In dieser Arbeit wurde der langsame Neutroneneinfang (s-Prozess) mit dem Nukleosynthese-Programm NETZ simuliert. Ziel solcher Programme ist es, die solare Häufigkeitsverteilung zu reproduzieren.
Der s-Prozess dient der Synthese von Elementen schwerer als Eisen und ereignet sich in astrophysikalischen Szenarien mit relativ geringen Neutronendichten. Dadurch sind die Neutroneneinfangzeiten meist größer als die Betazerfallszeiten und der Prozesspfad folgt dem Stabilitätstal in der Nuklidkarte. Aus diesem Grund sind die Reaktionsraten gut messbar und es steht ein umfangreiches Daten-Netzwerk zur Verfügung, welches in die Simulationen einfließen kann.
Man unterschiedet zwischen der schwachen- und der Hauptkomponente des s-Prozesses. Die schwache Komponente findet in massereichen Sternen (M > 8M⊙) beim Helium-Kernbrennen und Kohlenstoff-Schalenbrennen statt. Bei Temperaturen über 2.5 × 108 K wird die Reaktion 22Ne(α ,n)25Mg aktiviert, welche Neutronen liefert, die von der Eisensaat eingefangen werden. Bei einer mittleren Neutronendichte von 106/cm3 reicht die Neutronenbestrahlung jedoch nicht aus, um den Synthesefluss über die abgeschlossene Neutronenschale bei N = 50 hinweg zu treiben. Folglich werden nur Isotope zwischen Eisen und Yttrium (56 < A < 90) aufgebaut.
Schwerere Isotope (90 ≤ A ≤ 208) werden dagegen in der Hauptkomponente synthetisiert. Diese findet in thermisch pulsierenden AGB-Sternen statt, in denen während des Helium-Schalenbrennens Neutronen hauptsächlich über die Reaktion 13C(α ,n)16O zur Verfügung gestellt werden.
Am Ende der jeweiligen Brennphasen gibt es einen Anstieg von Temperatur und Neutronendichte, welche jedoch nicht die globale Häufigkeitsverteilung, wohl aber Verzweigungspunkte beeinflussen können. An diesen Punkten liegen die Neutroneneinfang- und Betazerfallszeiten in der gleichen Größenordnung, sodass der s-Prozesspfad aufspaltet.
Hinzu kommt, dass unter stellaren Bedingungen die Reaktionsraten starken Änderungen unterworfen sein können. Bei hohen Temperaturen und Dichten befinden sich die Kerne in angeregten Zuständen, die wie auch der Grundzustand Neutronen einfangen oder radioaktiv zerfallen können, jedoch bei veränderten Raten. Dieser Sachverhalt kann einen Einfluss auf die Häufigkeitsverteilung haben.
Das umfangreiche Reaktionsnetzwerk des s-Prozesses kann schnell und mit guter Genauigkeit mit dem Programm NETZ berechnet werden. Dabei muss dem Programm ein Neutronenpuls - der zeitliche Verlauf von Neutronendichte und Temperatur - vorgegeben werden. Ziel dieser Arbeit war es, einen geeigneten solchen Puls zu finden, um die bisherigen Ergebnisse von NETZ zu optimieren. Außerdem wurde eine Aktualisierung der Reaktionsraten und solaren Häufigkeitsverteilung durchgeführt.
Die neuen Neutronenpulse für die schwache- und Hauptkomponente liefern eine Verbesserung in der Übereinstimmung von berechneter und solarer Häufigkeit. Dabei konnte für die Hauptkomponente sowohl ein Profil mit einem rechteckigen als auch mit einem exponentiellen Verlauf der Neutronendichte gefunden werden.
Darüber hinaus bietet NETZ die Möglichkeit, den Einfluss veränderter Reaktionsraten auf die Häufigkeitsverteilung abzuschätzen. Dazu steht inzwischen auch ein Online-Interface zur Verfügung. Dies ist besonders interessant, wenn es neue Messungen z.B. für Neutroneneinfangreaktionen gibt und man die Relevanz für den s-Prozess bestimmen möchte. So konnte in dieser Arbeit die Bedeutung der kürzlich neu gemessenen Raten für 63,65Cu(n,γ) und 69,71Ga(n,γ) beurteilt werden.
Alzheimer’s disease (AD) is a common, age associated neurodegenerative disease that manifests as progressive dementia and is characterized by accumulation of the amyloid beta (Aβ) peptide which is a processing product of a transmembrane protein termed Alzheimer Amyloid Precursor Protein (APP). The Aβ peptide is generated by a sequential proteolytic processing of APP by two distinct proteases that are termed β- and γ-secretase. The β-secretase, also called BACE-1 or memapsin 2, belongs to the family of aspartyl proteases. BACE-1 evidently cleaves APP in an acidic endosomal compartment after endocytosis of APP, thereby facilitating Aβ peptide generation.
Sorting of transmembrane proteins is generally controlled by sorting signals in the cytoplasmic domains of the cargo proteins. The short cytoplasmic tail of BACE-1 with 23 amino acids contains a sorting signal of the acidic cluster, di-leucine (ACDL) type. The two Leu residues in this determinant are important for the clathrin mediated endocytosis of BACE-1, whereas the acidic residues together with the Leu are required for the endosomal sorting and recycling of BACE-1 back to the plasma membrane. The ACDL motif binds to the members of the GGA (Golgi-localized γ ear-containg ARF- binding proteins) family (GGA1-GGA3) that are involved in the sorting of BACE-1.
One of the major aims of this study was to address the role of flotillins in the intracellular sorting of BACE-1. This study shows that flotillin-1 directly binds to the di-leucine motif in the cytoplasmic tail of BACE-1, whereas flotillin-2 only shows an association mediated by flotillin-1. Flotillin-1 competes with GGA2 for the binding to BACE-1 tail, and thus influences the endosomal sorting of BACE-1. Importantly, depletion of flotillins results in an altered localization of the wildtype BACE-1, whereas the plasma membrane resident Leu to Ala (LLAA) mutant is not affected. Flotillin knockdown results in an accumulation of BACE-1, implicating reduced degradation and enhanced stability of this protease. Thus, flotillins appear to be important for the cellular targeting of BACE-1 and also influence the amyloidogenic processing of APP, as demonstrated by an increase in the amyloidogenic C-99 processing fragments.
When flotillin depleted cells were subjected to apoptotic stresses including Aβ25-35 synthetic peptide (inducer of the extrinsic apoptosis pathway) or several chemotherapeutic agents (staurosporine, brefeldin A, doxorubicin, carboplatin and paclitaxel: intrinsic apoptosis pathway) and cytotoxicity was determined, various apoptotic markers were activated in flotillin depleted cells. Caspase-3 and GGA3 are well accepted apoptosis markers and an enhanced caspase-3 cleavage was detected upon STS induced apoptosis in SH-SY5Y, HeLa, and HaCaT cell lines and increased GGA3 cleavage was observed in MCF7 cell line.
One of the major reasons for the apoptotic sensitivity in the absence of flotillins was a PI3K/Akt signaling defect. Neuroblastoma cells depleted of flotillins showed diminished levels of total Akt, phospho-Akt and phospho-ERK upon STS induced apoptosis. Since PI3K/Akt was the primary survival pathway affected upon STS induced apoptosis, ectopic expression of Akt in neuroblastoma cell line reduced caspase-3 cleavage and retarded apoptosis.
The direct downstream target of Akt is FOXO3a, whose localization was investigated in flotillin depleted cells. A major proportion of FOXO3a was localized in the nucleus of flotillin knockdown cells, implicating that FOXOs are active in these cells and subsequently trigger the transcription of death genes. Strikingly, an essential anti-apoptotic molecule and a major cancer target, Mcl-1, was inherently downregulated in flotillin knockdown cells. Mcl-1 is a chief member of the Bcl-2 family as it plays a pivotal role in cell survival and it is a critical protein in cancer therapeutics as suppression of Mcl-1 protein can curtail the survival and growth of tumorous cells.
Neuroblastoma cells were rescued from undergoing permanent damage due to STS induced apoptosis by overexpression of anti-apoptotic Bcl-2. Phorbol esters are well known PKC activators, and pre-treatment of neuroblastoma cells with phorbol esters along with staurosporine reduced caspase-3 cleavage.
These results demonstrate that absence of flotillins can sensitize cellular systems to apoptosis induction. The two main characteristics of cancer cells include resistance to apoptosis and unresponsiveness to chemotherapeutic agents. It is a well established fact that impaired apoptosis is central to tumour development. This study implicates that the downregulation of flotillin function can trigger cellular susceptibility and enhances apoptosis in response to conventional chemotherapeutic agents. Therefore, flotillins can serve as vital regulators in providing a more rational approach in molecular-targeted therapies for receding cancer growth and survival.
5-lipoxygenase (5-LO) is an enzyme with a substantial role in inflammatory processes. In vitro kinase assays using [32P]-ATP in combination with mutagenesis have revealed that serine residues 271, 523 and 663 can be phosphorylated by MK2, PKA and ERK2 kinases, respectively. A few available reports regarding 5-LO protein sequence have covered up to 30% of the sequence after amino acid sequencing including Ser663. In LCMS/MS analyses of 5-LO tryptic digests from different cellular sources different peptides have been detected; however, none of the three phosphorylations has been detected and only Ser663 was included in the covered sequence.
As there was no comprehensive mass spectrometric analysis of 5-LO, the purpose of this study was to optimize the experimental conditions under which detection of the aforementioned phosphorylation events, as well as other possible post-translational modifications (PTMs), would be feasible. Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) was used for peptide analysis of 5-LO cleaved either by chemical reagents or by proteases. Sequence coverage of 5-LO could be enhanced to be close to completion by combination of results from digestions by trypsin, AspN and chymotrypsin. In-gel trypsin digestion followed by in-solution AspN digestion proved to be a useful sample treatment for reproducible detection of the Ser271-containing peptide.
Nevertheless, in none of the examined cleavage protocols the sequence around Ser523 was detected reproducibly or with acceptable signal intensity for subsequent peptide fragmentation. Propionic anhydride and sulfo-NHS-SS-biotin cross-linker (EZ-linkTM), were used for derivatization of lysine side chains and hindrance of lysine residue recognition by trypsin. Phosphopeptide enrichment became possible after tryptic digestion of these samples, not only due to formation of an individual Ser523-containing peptide, but also because TiO2-mediated enrichment, which is performed in acidic pH, was not impaired by positively charged free lysine side chains. Additionally, biotinylation of lysine residues was exploited for an intermediate enrichment step of the lysine containing peptides, prior to TiO2 phosphopeptide enrichment.
MALDI-MS analysis after in-vitro phosphorylation of 5-LO by the three kinases showed that Ser271 was phosphorylated in the MK2 and PKA kinase assays, while Ser523 was phosphorylated only in the PKA kinase assay. Surpisingly, no phosphopeptides were detected in the in-vitro kinase assays with ERK2, even though the unmodified counterpart of the Ser663-containing peptide was easily detected. The detection limit for each of the three phosphorylation sites was determined by the use of custom made phosphopeptides and an amount of 0.06 pmol of phosphopeptide in 1 μg 5-LO (representing 0.5% phosphorylation rate) was sufficient in all cases for successful enrichment and detection by MS.
In-vitro kinase assays with [32P]-ATP were performed for some kinases that were expected to phosphorylate 5-LO according to in-silico data. Three members of the Src tyrosine kinase family (Fgr, Hck and Yes) and the Ser/Thr specific kinase DNA-PK used 5-LO as their substrate and mainly residues at the N-terminal part of 5-LO were detected phosphorylated by MS (e.g. Y42, Y53). Additional in-vitro assays for recombinant 5-LO modification included incubation with glutathione or compound U73122, previously described as inhibitor of 5-LO.
Since in-vitro assays might have generated artifacts, a method for 5-LO purification from human cells was sought, in order to examine the modification state of the protein in the cellular context. ATP-agarose affinity purification and anti-5-LO immunoprecipitation proved inappropriate for sample purification for MALDI-MS analysis. Consequently, two human cell lines that are able to express 5-LO (Rec-1 Blymphocytes and MM6 monocytes) were transduced with a DNA cassette that contained recombinant human 5-LO sequence with an attached N-terminal FLAG-tag. Anti-FLAG immunoprecipitation was then performed effectively in cell lysates and the precipitated FLAG-5-LO was separated by SDS-PAGE before MALDI-MS analysis.
The examined cell stimuli were expected to result to phosphorylation of 5-LO at Ser523 by PKA in Rec-1 cells and to phosphorylation of Ser271 and/or Ser663 in MM6 cells by activated MK2 and ERK2, respectively. Additionally, under the conditions of MM6 cell stimulation, Fgr, Hck and Yes kinases, which phosphorylated 5-LO in vitro, were expected to be activated and the possibility of 5-LO phosphorylation on tyrosine was investigated. Although immunoblotting results indicated that all the aforementioned phosphorylation events existed in the examined samples, MALDI-MS analysis verified only phosphorylation on Ser271 in differentiated MM6 cells, interestingly regardless of cell stimulation.
Finally, the primary amine derivatization procedure by EZ-linkTM was utilized for MS analysis of lysine rich proteins. In the past, chemical propionylation of histones had been employed prior to trypsin digestion; however it was easily confused in MS with combinations of other PTMs (e.g. acetylation, methylation). Moreover, propionylation is a PTM for histone H3 and this information was lost. Consequently, the EZ-link reagent was more useful for analysis of histones, as unambiguous assignment of PTMs and detection of native propionylation on bovine H3 became possible.
Mechanisms behind how the immune system signals to the brain in response to systemic inflammation are not fully understood. Transgenic mice expressing Cre recombinase specifically in the hematopoietic lineage in a Cre reporter background display recombination and marker gene expression in Purkinje neurons. Here we show that reportergene expression in neurons is caused by intercellular transfer of functional Cre recombinase messenger RNA from immune cells into neurons in the absence of cell fusion. In vitro purified secreted extracellular vesicles (EVs) from blood cells contain Cre mRNA, which induces recombination in neurons when injected into the brain. Although Cre-mediated recombination events in the brain occur very rarely in healthy animals, their number increases considerably in different injury models, particularly under inflammatory conditions, and extend beyond Purkinje neurons to other neuronal populations in cortex, hippocampus, and substantia nigra. Recombined Purkinje neurons differ in their miRNA profile from their nonrecombined counterparts, indicating physiological significance. These observations reveal the existence of a previously unrecognized mechanism to communicate RNA-based signals between the hematopoietic system and various organs, including the brain, in response to inflammation.
Als am 11.10.1987 der Stern- Reporter Sebastian Knauer den toten, erst kurz zuvor vom Amt des Ministerpräsidenten in Kiel zurückgetretenen, Uwe Barschel (CDU) in der Badewanne seines Genfer Hotelzimmers fotografierte1, schuf er eine Fotografie, deren Bekanntheit und Streitbarkeit bis heute nicht verblasst ist.
Securities transaction tax in France: impact on market quality and inter-market price coordination
(2014)
The general concept of a Securities Transaction Tax is controversial among academics and politicians. While theoretical research is quite advanced, the empirical guidance in a fragmented market context is still scarce. Possible negative effects for market liquidity and market efficiency are theoretically predicted, but have not been empirically tested yet. In light of the agreement of eleven European member states to implement an STT, this study aims to give a comprehensive overview of the effects of the STT, introduced in France in 2012, on liquidity demand, liquidity supply, volatility and inter-market information transmission. The results show that the STT has led to a decline in liquidity demand, has had a detrimental effect on liquidity supply and negatively influences the inter-market information transmission efficiency. However, no effect on volatility can be observed.
Die Stellungnahme befasst sich mit einem wichtigen Aspekt der Offenlegung der Bezüge von Entscheidungsträgern im Bankensektor. Komplementär zu der Diskussion um die Veröffentlichung der Vergütung von Vorstandsmitgliedern börsennotierter Unternehmen ist auch auf Landeseben versucht worden, die Transparenz der Vergütung von Führungskräften kommunaler oder landeseigener Unternehmen zu erhöhen. Namentlich sind die Träger der Sparkassen durch den neuen § 19 Abs. 6 des Sparkassengesetzes von Nordrhein-Westfalen verpflichtet worden, darauf „hinzuwirken“, dass die „gewährten Bezüge jedes einzelnen Mitglieds des Vorstands, des Verwaltungsrates und ähnlicher Gremien unter Namensnennung“ veröffentlich werden. Diese Vorschrift ist jedoch weitgehend wirkungslos geblieben; nicht zuletzt weil das OLG Köln in einer einstweiligen Verfügung die Vorschrift mangels Gesetzgebungskompetenz des Landes als nichtig behandelt hat. In dieser Situation ist am 8. August 2013 der Vorschlag eines Gesetzes „zur Offenlegung der Bezüge von Sparkassenführungskräften im Internet“ durch die Fraktion der Piraten im Landtag Nordrhein-Westfalen eingebracht worden. Der Entwurf ist Gegenstand der Stellungnahme, die Helmut Siekmann für den Haushalts- und Finanzausschuss des Landtags Nordrhein-Westfalen erstellt hat. Sie stellt maßgebend darauf ab, dass die Sparkassen als Anstalten des öffentlichen Rechts einen öffentlichen Auftrag zu erfüllen haben und den Grundsätzen des Verwaltungsorganisationsrechts unterliegen. Als Teil der (leistenden) Verwaltung müssen sie Transparenz- und Kontrollansprüchen der Bürger und ihren Repräsentanten in den Parlamenten genügen.
In the United States, on April 1, 2014, the set of rules commonly known as the "Volcker Rule", prohibiting proprietary trading activities in banks, became effective. The implementation of this rule took more than three years, as “proprietary trading” is an inherently vague concept, overlapping strongly with genuinely economically useful activities such as market-making. As a result, the final Rule is a complex and lengthy combination of prohibitions and exemptions.
In January 2014, the European Commission put forward its proposal on banking structural reform. The proposal includes a Volcker-like provision, prohibiting large, systemically relevant financial institutions from engaging in proprietary trading or hedge fund-related business. This paper offers lessons to be learned from the implementation process for the Volcker rule in the US for the European regulatory process.
Der vorliegende Artikel analysiert systematisch die Erreichung der MiFID-Ziele anhand der wissenschaftlichen Literatur. Ziel der MiFID ist es, die Rahmenbedingungen für einen effizienten und kostengünstigen Wertpapierhandel zu schaffen. Erreicht werden soll dies durch die Verschärfung des Wettbewerbs, die Integration der Märkte, die Offenlegung von Handelsintentionen und -geschäften sowie die Stärkung der rechtlichen Position der Investoren. Im Ergebnis zeigt sich, dass die Förderung des Wettbewerbes als erfolgreich bewertet wird, aber die regulatorischen Möglichkeiten der Marktintegration nicht ausgeschöpft werden. Ferner wird die Forderung nach einheitlichen Transparenzbestimmungen für alle Ordermechanismen nur teilweise umgesetzt. Der Anleger erfährt letztlich gegenüber Finanzintermediären durch die MiFID keinen höheren Schutz.
Im Zeitalter von Globalisierung und Massenmigration ergeben sich derzeit nicht nur neue Fragestellungen und Perspektiven für die germanistische Exilforschung, es lässt sich auch ein wachsendes Interesse der Öffentlichkeit am Thema des Exils beobachten. Entscheidende Impulse erhielt die Auseinandersetzung in jüngster Vergangenheit ins besondere durch Herta Müller und ihre Forderung, ein "Museum des Exils" zu gründen. Das Exil in diesem Sinne "in der gegenwärtigen deutschen Erinnerungskultur zu verankern", ist erklärtes Ziel der vom Literaturarchiv Marbach und der Deutschen Nationalbibliothek in Frankfurt am Main initiierten virtuellen Ausstellung 'Künste im Exil', die im September 2013 offiziell freigeschaltet wurde. Das Netzwerkprojekt interessiert sich dabei vor allem auch für die "unerwarteten Verbindungslinien zwischen historisch spezifischen Exil-Situationen". […]
Mit Beiträgen zu Marica Bodrožić, Saša Stanisic, Olga Grjasnowa, Doron Rabinovici, Abbas Khider und Michael Lentz versammelt das Heft einige exemplarische Lektüren zu Exiltexten der Gegenwart. Zum Weiter lesen regt die von Philipp Wulf erstellte Bibliographie zu Texten von in Deutschland lebenden Exilautoren an, die auf der Internetseite der Walter A. Berendsohn Forschungsstelle eingestellt ist. Die Arbeit des "Writers in exile"-Programms stellt Franziska Sperr in ihrem Artikel vor. Yvonne Siebels berichtet über digitale Exil-Portale, zu der auch die virtuelle Ausstellung Künste im Exil gehört. Andreas Marquet stellt den Beitrag zur Tänzerin und Autorin Jo Mihaly vor, mit dem die Forschungsstelle in der digitalen Ausstellung vertreten ist.
Financial innovation is, as usual, faster than regulation. New forms of speculation and intermediation are rapidly emerging. Largely as a result of the evaporation of trust in financial intermediation, an exponentially increasing role is being played by the so-called peer to peer intermediation. The most prominent example at the moment is Bitcoin.
If one expects that shocks in these markets could destabilize also traditional financial markets, then it will be necessary to extend regulatory measures also to these innovations.
Fünf Jahre nach Beginn der Banken- und Staatsschuldenkrise („Finanzkrise“) kämpfen wir weiterhin mit den elementaren Problemen: Bei Märkten und Marktteilnehmern fehlt es an Stabilität und Vertrauen. Viele Banken stehen immer noch nicht auf eigenen Füßen und nehmen die ihnen in Europa traditionell zukommende zentrale Rolle für Wachstum und Entwicklung nicht wahr. Den guten Absichten, auf die sich die großen politischen Mächte während der ersten G-20 Treffen 2008 und 2009 verständigt hatten, ist eine Reihe von sinnvollen Ideen und Konzepten gefolgt. Die Voraussetzungen für einen grundlegenden reformerischen Erfolg sind somit gegeben – doch nun muss die Umsetzung folgen. Dazu bedarf es mutiger Entscheidungen. Im Jahr 2014 muss die europäische Politik gleich mehrere Weichen stellen. Der Bundesregierung kommt dabei die Schlüsselrolle zu. Sie muss den Mut haben zu radikaler Ordnungspolitik!
This article discusses the recent proposal for debt restructuring in the euro zone by Pierre Paris and Charles Wyplosz. It argues that the plan cannot realize the promised debt relief without producing moral hazard. Ester Faia revisits the Redemption Fund proposed in November 2011 by the German Council of Economic Experts and argues that this plan, up to date, still remains the most promising path towards succesful debt restructuring in Europe.
Das ursprüngliche Ziel des Erneuerbare-Energien-Gesetz war die Verringerung der Emissionen. Eigentlich hat die Politik bereits ein Instrument an der Hand, das dieses Ziel fokussiert und kostensparend erreichen kann: den Handel mit CO2-Zertifikaten. Der Autor argumentiert, dass das Nebeneinander von CO2-Handel und EEG höchst unproduktiv ist und schleunigst beendet werden sollte. Ein plausibleres Argument für den politischen Erfolg des EEG und das derzeitige Herumdoktern im Detail ist, dass die Politik mit dem EEG Industriepolitik betreiben und die Kosten auf zukünftige Parlamente und Generationen überwälzen kann.
On November 8, 2013, several members of the British House of Lords’ Subcommittee A conducted a hearing at the ECB in Frankfurt, Germany, on “Genuine Economic and Monetary Union and its Implications for the UK”. Professors Otmar Issing and Jan Pieter Krahnen were called as expert witnesses.
The testimony began with a general discussion on the elements considered necessary for a functioning internal market. Do economic union and monetary union require a fiscal union or even a political union, beyond the elements of the banking union currently being prepared? In this context, also the critique of the German current account surplus and the international expectations that Germany stimulate internal demand to support growth in crisis countries, were discussed.
With regard to the monetary union, the members of the subcommittee asked for an assessment of how European nations and the banking industry would have fared in the banking crisis that followed the Lehman collapse, had there not been a common currency. Given the important role that the ECB has played in the course of the crisis management, the members further asked for an evaluation of the OMT-program of the ECB and also if the monetary union is in need of common debt instruments, in order to provide the ECB with the possibility of buying EU liabilities, comparable to the Fed buying US Treasury bonds. Finally, the dual role of the ECB for monetary policy and banking supervision was an issue touched on by several questions.
In many cases, the dire situation of public finances calls into question the very soundness of sovereigns and prompts corrective actions with far-reaching consequences. In this context, European authorities responded with several measures on different fronts, for instance by passing the "Fiscal Compact", which entered into force on January 1, 2013. Of critical importance in this framework is the assessment of a country’s situation by way of statistical measures, in order to take corrective actions when called for according to the letter of the law. If these statistics are not correct, there is a risk of imposing draconian measures on countries that do not really need it.
Before the 2007–09 crisis, standard risk measurement methods substantially underestimated the threat to the financial system. One reason was that these methods didn’t account for how closely commercial banks, investment banks, hedge funds, and insurance companies were linked. As financial conditions worsened in one type of institution, the effects spread to others. A new method that more accurately accounts for these spillover effects suggests that hedge funds may have been central in generating systemic risk during the crisis.
Social impact bonds are a special type of bond whose purpose is to provide long term funds to projects with a social impact. Especially in the UK and in the US these bonds are increasingly being used to raise funds to finance government projects. Their return depends on the social improvements achieved. Especially in times of crisis, governments lack funds to prevent the social consequences of recessions. Faia argues that the European Union should develop an equivalent to the British Social Finance Ltd. to finance projects for social improvement.
Neither Northerners are willing to invest in a South they perceive as unwilling to undertake necessary structural reforms, nor are Southerners willing to invest in their countries in a climate of austerity and policy uncertainty imposed, in their view, by the North. This results in a vicious cycle of mistrust. However, as the author argues, big steps in the direction of reforms may provide just enough thrust to break out of this vicious cycle, propel southern countries – and especially Greece – to a much happier future, and promote the chances for more balanced economic performance in North and South.
Social Security rules that determine retirement, spousal, and survivor benefits, along with benefit adjustments according to the age at which these are claimed, open up a complex set of financial options for household decisions. These rules influence optimal household asset allocation, insurance, and work decisions, subject to life cycle demographic shocks, such as marriage, divorce, and children. Our model-based research generates a wealth profile and a low and stable equity fraction consistent with empirical evidence. We confirm predictions that wives will claim retirement benefits earlier than husbands, while life insurance is mainly purchased by younger men. Our policy simulations imply that eliminating survivor benefits would sharply reduce claiming differences by sex while dramatically increasing men’s life insurance purchases.
One of the motivations for establishing a European banking union was the desire to break the ties with between national regulators and domestic financial institutions in order to prevent regulatory capture. However, supervisory authority over the financial sector at the national level can also have valuable public benefits. The aim of this policy letter is to detail these public benefits in order to counter discussions that focus only on conflicts of interest. It is informed by an analysis of how financial institutions interacted with policy-makers in the design of national bank rescue schemes in response to the banking crisis of 2008. Using this information, it discusses the possible benefits of close cooperation between financial institutions and regulators and analyzes these in the wake of a European banking union.
The exposure to tobacco smoke during pregnancy is considered to be amongst the most harmful avoidable risk factors. In this scientometric and gender study scientific data on smoking and pregnancy was analyzed using a variety of objective scientometric methods like the number of scientific contributions, the number of citations and the modified h-index in combination with gender-specific investigations. Covering a time period from 1900 to 2012, publishing activities of 27,955 authors, institutions and countries, reception within the international scientific community and its reactions were analyzed and interpreted. Out of 10,043 publications the highest number of scientific works were published in the USA (35.5%), followed by the UK (9.9%) and Canada (5.3%). These nations also achieve the highest modified h-indices of 128, 79 and 62 and the highest citation rates of 41.4%, 8.6% and 5.3%, respectively. Out of 12,596 scientists 6,935 are female (55.1%), however they account for no more than 49.7% of publications (12,470) and 42.8% of citations (172,733). The highest percentage of female experts about smoking and pregnancy is found in Australasia (60.7%), while the lowest is found in Asia (41.9%). The findings of the study indicate an increase in gender equality as well as in quantity and quality of international scientific research about smoking and pregnancy in the future.
In this work we study basic properties of unstable particles and scalar hadronic resonances, respectively, within simple quantum mechanical and quantum field theoretical (effective) models. The term 'particle' is usually assigned to entities, described by physical theories, that are able to propagate over sufficiently large time scales (e.g. from a source to a detector) and hence could be identified in experiments - one especially should be able to measure some of their distinct properties like spin or charge. Nevertheless, it is well known that there exists a huge amount of unstable particles to which it seems difficult to allocate such definite values for their mass and decay width. In fact, for extremely short-lived members of that species, so called resonances, the theoretical description turns out to be highly complicated and requires some very interesting concepts of complex analysis.
In the first chapter, we start with the basic ideas of quantum field theory. In particular, we introduce the Feynman propagator for unstable scalar resonances and motivate the idea that this kind of correlation function should possess complex poles which parameterize the mass and decay width of the considered particle. We also brie
y discuss the problematic scalar sector in particle physics, emphasizing that hadronic loop contributions, given by strongly coupled hadronic intermediate states, dominate its dynamics. After that, the second chapter is dedicated to the method of analytic continuation of complex functions through branch cuts. As will be seen in the upcoming sections, this method is crucial in order to describe physics of scalar resonances because the relevant functions to be investigated (namely, the Feynman propagator of interacting quantm field theories) will also have branch cuts in the complex energy plane due to the already mentioned loop contributions. As is consensus among the physical community, the understanding of the physical behaviour of resonances requires a deeper insight of what is going on beyond the branch cut. This will lead us to the idea of a Riemann surface, a one-dimensional complex manifold on which the Feynman propagator is defined.
We then apply these concepts to a simple non-relativistic Lee model in the third chapter and demonstrate the physical implications, i.e., the motion of the propagator poles and the behaviour of the spectral function. Besides that, we investigate the time evolution of a particle described by such a model. All this will serve as a detailed preparation in order to encounter the rich phenomena occuring on the Riemann surface in quantum field theory. In the last chapter, we finally concentrate on a simple quantm field theoretical model which describes the decay of a scalar state into two (pseudo)scalar ones. It is investigated how the motion of the propagator poles is in
uenced by loop contributions of the two (pseudo)scalar particles. We perform a numerical study for a hadronic system involving a scalar seed state (alias the σ-meson) that couples to pions. The unexpected emergence of a putative stable state below the two-pion threshold is investigated and it is claeifieed under which conditions such a stable state appears.
There are no European recommendations on issues specifically related to lung transplantation (LTX) in cystic fibrosis (CF). The main goal of this paper is to provide CF care team members with clinically relevant CF-specific information on all aspects of LTX, highlighting areas of consensus and controversy throughout Europe. Bilateral lung transplantation has been shown to be an important therapeutic option for end-stage CF pulmonary disease. Transplant function and patient survival after transplantation are better than in most other indications for this procedure. Attention though has to be paid to pretransplant morbidity, time for referral, evaluation, indication, and contraindication in children and in adults. This review makes extensive use of specific evidence in the field of lung transplantation in CF patients and addresses all issues of practical importance. The requirements of pre-, peri-, and postoperative management are discussed in detail including bridging to transplant and postoperative complications, immune suppression, chronic allograft dysfunction, infection, and malignancies being the most important. Among the contributors to this guiding information are 19 members of the ECORN-CF project and other experts. The document is endorsed by the European Cystic Fibrosis Society and sponsored by the Christiane Herzog Foundation.
Objective: To analyze Mucograft (MG), a recently introduced collagen matrix, in vitro and in vivo, and compare it with BioGide (BG), a well-established collagen membrane, as control.
Material and methods: A detailed analysis of the materials surface and ultra-structure was performed. Cellular growth patterns and proliferation rates of human fibroblasts on MG and BG were analyzed in vitro. In addition, the early tissue reaction of CD-1 mouse to these materials was analyzed by means of histological and histomorphometrical analysis.
Results: MG showed a three-fold higher thickness both in dry and wet conditions, when compared to BG. The spongy surface of BG significantly differed from that of MG. Cells showed a characteristic proliferation pattern on the different materials in vitro. Fibroblasts tended to proliferate on the compact layers of both collagens, with the highest values on the compact side of BG. In vivo, at day three both materials demonstrated good tissue integration, with a mononuclear cell sheet of fibroblasts on all surfaces, however, without penetrating into the materials.
Conclusions: The findings of this study showed that MG and BG facilitate cell proliferation on both of their surfaces in vitro. In vivo, these two materials induce a comparable early tissue reaction, while serving as cell occlusive barriers.
This work deals with the determination of the scale parameter ΛM̄S̄ from lattice QCD and perturbation theory results of the static quark-antiquark potential for nf = 2. The investigation is done in momentum space. Lattice methods as well as perturbation theory calculations are introduced. Another part of this work concerns the calculation of the quark-antiquark potential from gauge link configurations for nf = 2 + 1 + 1.
Low-energy effective models for two-flavor quantum chromodynamics and the universality hypothesis
(2014)
Die Untersuchung der Natur auf extremen Längenskalen hat seit jeher zu bahnbrechenden Einsichten und Innovationen geführt. Insbesondere zu unserem heutigen Verständnis, dass Nukleonen (Protonen und Neutronen) aus Quarks zusammengesetzt sind, die infolge der starken Wechselwirkung, vermittelt durch Gluonenaustausch, gebunden sind. Mit dem Aufkommen des Quarkmodells wurde bald die Quantenchromodynamik (QCD) erfolgreich in der Beschreibung vieler messbarer Eigenschaften der starken Wechselwirkung. Um es mit Goethe zu sagen: mit den modernen Hochenergie-Beschleuniger-Experimenten wird versucht unser Verständnis davon zu verbessern, was die Welt im Innersten zusammenhält. Am Large Hadron Collider (LHC) werden beispielsweise Protonen derart beschleunigt und miteinander zur Kollision gebracht, dass bislang unerreichte Energiedichten auftreten, infolge derer Temperatur und baryochemisches Potential Werte annehmen, die mit denen des frühen Universums vergleichbar sind. Es gibt sowohl theoretische als auch experimentelle Hinweise darauf, dass hadronische Materie mit zunehmender Temperatur und/oder zunehmendem baryochemischen Potentials einen Phasenübergang durchläuft, hin zu einem exotischen Zustand, der als Quark-Gluon-Plasma bekannt ist. Dieser Übergang wird begleitet von einem sogenannten chiralen Übergang. Es ist eine wichtige Frage, ob es sich bei diesem chiralen Übergang um einen echten Phasenübergang (von erster bzw. zweiter Ordnung) handelt, oder ob ein sogenannter crossover vorliegt. Einige Resultate deuten auf einen crossover für verschwindendes baryochemisches Potential und einen Phasenübergang erster Ordnung für verschwindende Temperatur hin, lassen jedoch noch keinen endgültigen Schluss zu, ob dies tatsächlich der Realität entspricht. Wenn ja, so liegt die Annahme nahe, dass ein kritischer Endpunkt existiert, an dem der chirale Übergang von zweiter Ordnung ist. In der Tat existiert ein kritischer Endpunkt in einigen theoretischen Zugängen zur Beschreibung des chiralen Phasenübergangs, deren Aussagekraft seit jeher lebhaft diskutiert wird. Ein zentrales Ziel des zukünftigen CBM-Experiments an der GSI in Darmstadt ist es, die Existenz im Experiment zu überprüfen.
In der Nähe des QCD-(Phasen)übergangs ist es die Abwesenheit jeglicher perturbativer Entwicklungsparameter, die exakte analytische Berechnungen verbietet. Das gleiche gilt für realistische effektive Modelle für QCD. Nichtperturbative Methoden sind daher unverzichtbar für die Untersuchung des QCD-Phasendiagramms. Zu den populärsten dieser Zugänge gehören Gitter-QCD, Resummierungsverfahren, der Dyson-Schwinger-Formalismus, sowie die Funktionale Renormierungsgruppe (FRG). All diese Methoden ergänzen sich gegenseitig und werden zum Teil auch miteinander kombiniert. Eine der Stärken der FRG-Methode ist, dass sie nicht nur erfolgreich auf effektive Modelle angewendet werden kann, sondern auch auf QCD selbst. Für letztere Ab-Initio-Rechnungen sind die aus effektiven Modellen für QCD gewonnenen Resultate von grossem Wert.
Der Schwerpunkt der vorliegenden Arbeit liegt auf der Fragestellung von welcher Ordnung der chirale Phasenübergang im Fall von genau zwei leichten Quarksorten ist. Problemstellungen wie die Suche nach einer Antwort auf die Frage nach den Bedingungen für die Existenz eines Phasenübergangs zweiter Ordnung, die Bestimmung der Universalitätsklasse in diesem Fall etc. erfordern Wissen aus verschiedenen Gebieten.
Kapitel 1 besteht aus einer allgemeinen Einleitung.
In Kapitel 2 stellen wir zunächst einige allgemeine Aspekte von Phasenübergängen dar, die von besonderer Relevanz für das Verständnis des Renormierungsgruppen-Zugangs zu ebendiesen sind. Unser Fokus liegt hierbei auf einer kritischen Untersuchung der Universalitätshypothese. Insbesondere die Rechtfertigung des linearen Sigma-Modells als effektive Theorie für den chiralen Ordnungsparameter beruht auf der Gültigkeit selbiger.
Kapitel 3 beschäftigt sich mit dem chiralen Phasenübergang von einem allgemeinen Standpunkt aus. Wir ergünzen wohlbekannte Fakten durch eine detaillierte Diskussion der sogenannten O(4)-Hypothese. Die Überprüfung der Gültigkeit selbiger wird schließlich in Kapitel 6 und 7 in Angriff genommen.
In Kapitel 4 stellen wir die von uns benutzte FRG-Methode vor. Außerdem diskutieren wir den Zusammenhang zwischen effektiven Theorien für QCD und der QCD selbst.
Kapitel 5 behandelt ein mathematisches Thema, das für alle unserer Untersuchungen unabdingbar ist, nämlich die systematische Konstruktion polynomialer Invarianten zu einer gegebenen Symmetrie. Wir präsentieren einen einfachen, jedoch neuartigen, Algorithmus für die praktische Konstruktion von Invarianten einer gegebenen polynomialen Ordnung.
Kapitel 6 widmet sich Renormierungsgruppen-Studien einer Reihe dimensional reduzierter Theorien. Von zentralem Interesse ist hierbei das lineare Sigma-Modell, insbesondere in Anwesenheit der axialen Anomalie. Es stellt sich heraus, dass die Fixpunkt-Struktur des letzteren vergleichsweise kompliziert ist und ein tieferes Verständnis der zugrundeliegenden Methode sowie ihrer Annahmen erfordert. Dies führt uns zu einer sorgfältigen Analyse der Fixpunkt-Struktur von Modellen verschiedenster Symmetrien. Im Zusammenhang mit der Untersuchung des Einflusses von Vektor- und Axial-Vektor-Mesonen stoßen wir hierbei auf eine neue Universalitä}tsklasse.
Während wenig Spielraum für die Wahl der Symmetriegruppe der effektiven Theorie für den chiralen Ordnungsparameter besteht, ist die Identifizierung der Ordnungsparameter-Komponenten mit den relevanten mesonischen Freiheitsgraden hochgradig nichttrivial. Diese Wahl entspricht der Wahl einer Darstellung der Gruppe und kann zur Zeit nicht eindeutig aus der QCD hergeleitet werden. Es ist daher unerlässlich, verschiedene Möglichkeiten auszutesten. Eine wohlbekannte Wahl besteht darin, das Pion und seinen chiralen Partner, das Sigma-Meson, der O(4)-Darstellung für SU(2)_A x SU(2)_V zuzuordnen, welche einen Phasenübergang zweiter Ordnung erlaubt. Dieses Szenario ist jedoch nur dann sinnvoll, wenn nahe der kritischen Temperatur alle anderen Mesonen entsprechend schwer sind. Im Fall von genau zwei leichten Quarkmassen erfordert dies eine hinreichend große Anomaliestärke. Berücksichtigt man zusätzlich zum Pion und Sigma-Meson auch das Eta-Meson und das a_0-Meson, liefern unsere derzeitigen expliziten Rechnungen keinen Nachweis für die Existenz eines Phasenübergang zweiter Ordnung. Stattdessen spricht die Abwesenheit eines physikalischen (hinsichtlich der Massen) infrarot-stabilen Fixpunktes für einen fluktuationsinduzierten Phasenübergang erster Ordnung. Dieses Ergebnis ist auch zu erwarten (jedoch nicht impliziert), allein durch die Existenz zweier quadratischer Invarianten. Es besteht jedoch immer noch eine hypothetische Chance auf einen Phasenübergang zweiter Ordnung in der SU(2)_A x U(2)_V -Universalitätsklasse. Dies wäre der Fall, wenn der entsprechende von uns gefundene unphysikalische infrarot-stabile Fixpunkt physikalisch werden sollte in höherer Trunkierungsordnung. Interessanterweise finden wir bei endlicher Temperatur für gewisse Parameter einen Phasenübergang zweiter Ordnung. Es ist unklar, ob diese Wahl der Parameter in den Gültigkeitsbereich der dimensional reduzierten Theorie fällt.
Erst vor kurzem (Ende September 2013) wurde die Existenz eines infrarot-stabilen U(2)_A x U(2)_V-symmetrischen Fixpunkts durch Pelissetto und Vicari verifiziert (die zugehörige anomale Dimension ist mit 0.12 angegeben). Dieses Resultat war sehr
überraschend, da für zwei leichte Quarksorten und abwesende Anomalie ein Phasenübergang erster Ordnung relativ gesichert erschien, insbesondere durch die Epsilon-Entwicklung. Offensichtlich versagt letztere jedoch im Limes D=3, also für drei räumliche Dimensionen, da lediglich Fixpunkte gefunden werden können, die auch nahe D=4 existieren. Inspiriert durch diesen wichtigen Fund führen wir eine FRG-Fixpunktstudie in lokaler Potential-Näherung und hoher Trunkierungsordnung (bis zu zehnter Ordnung in den Feldern) durch. Die Stabilitätsanalyse besitzt jedoch leider keine Aussagekraft, da die Stabilitätsmatrix für den Gaußschen Fixpunkt marginale Eigenwerte besitzt. Wir sind überzeugt davon, dass dies nicht mehr der Fall ist, wenn man über die lokale Potential-Näherung hinausgeht und eine nichtverschwindende anomale Dimension zulässt. Die bisherigen Resultate verdeutlichen die Limitierungen der lokalen Potential-Näherung und der Epsilon-Entwicklung, auf denen unsere Untersuchungen zur Universalitätshypothese in weiten Teilen beruhen. Systematische Untersuchungen der Fixpunktstruktur von Modellen mit acht Ordnungsparameter-Komponenten wurden in der Literatur im Rahmen der Epsilon-Entwicklung durchgeführt und im Rahmen dieser Dissertation innerhalb der lokalen Potential-Näherung. Die meisten der Vorhersagen der Epsilon-Entwicklung konnten bestätigt werden, einige hingegen werden in Frage gestellt durch das Auftauchen marginaler Stabilitätsmatrix-Eigenwerte.
Einige wichtige Fragestellungen können nicht im Rahmen einer dimensional reduzierten Theorie behandelt werden, da die explizite Temperaturabhängigkeit in diesem Fall eliminiert wurde.
Insbesondere ist es in diesem Fall nicht möglich, die Stärke eines Phasenübergangs erster Ordnung vorherzusagen, da diese von Observablen (Meson-Massen und die Pion-Zerfallskonstante im Vakuum) abhängen, an die man bei verschwindender Temperatur fitten muss. Dieser Umstand führt uns zu solchen FRG-Studien, in denen die Temperatur als expliziter Parameter verbleibt.
Ein beträchtlicher Teil der für die vorliegende Dissertation zur Verfügung stehenden Arbeitszeit wurde darauf verwendet, eigene Implementierungen geeigneter Algorithmen zur numerischen Lösung der auftretenden partiellen Differentialgleichungen zu finden. Exemplarische Routinen (welche ausschließlich wohlbekannte Methoden nutzen) sind in einem Anhang zur Verfügung gestellt. Das Hauptziel der vorliegenden Arbeit, die Anwendung auf effektive Modelle für QCD, wird in Kapitel 7 präsentiert. Unsere (vorläufigen) FRG-Studien des linearen Sigma-Modells mit axialer Anomalie bei nichtverschwindender Temperatur erlauben verschiedene Szenarien. Sowohl einen extrem schwach ausgeprägten, als auch einen sehr deutlichen Phasenübergang erster Ordnung, ganz abhängig von der Wahl der Ultraviolett-Abschneideskala und oben genannter Parameter. Sogar ein Phasenübergang zweiter Ordnung scheint möglich für gewisse Parameterwerte. Um verlässliche Schlussfolgerungen zu ziehen, sind weitere Untersuchungen nötig und bereits im Gange. In Kapitel 7 verifizieren wir außerdem bereits bekannte numerische Resultate für das Quark-Meson-Modell.
This paper makes a conceptual contribution to the effect of monetary policy on financial stability. We develop a microfounded network model with endogenous network formation to analyze the impact of central banks' monetary policy interventions on systemic risk. Banks choose their portfolio, including their borrowing and lending decisions on the interbank market, to maximize profit subject to regulatory constraints in an asset-liability framework. Systemic risk arises in the form of multiple bank defaults driven by common shock exposure on asset markets, direct contagion via the interbank market, and firesale spirals. The central bank injects or withdraws liquidity on the interbank markets to achieve its desired interest rate target. A tension arises between the beneficial effects of stabilized interest rates and increased loan volume and the detrimental effects of higher risk taking incentives. We find that central bank supply of liquidity quite generally increases systemic risk.
This paper explores consequences of consumer education on prices and welfare in retail financial markets when some consumers are naive about shrouded add-on prices and firms try to exploit it. Allowing for different information and pricing strategies we show that education is unlikely to push firms to disclose prices towards all consumers, which would be socially efficient. Instead, price discrimination emerges as a new equilibrium. Further, due to a feedback on prices, education that is good for consumers who become sophisticated may be bad for consumers who stay naive and even for the group of all consumers as a whole
This paper makes a conceptual contribution to the effect of monetary policy on financial stability. We develop a microfounded network model with endogenous network formation to analyze the impact of central banks' monetary policy interventions on systemic risk. Banks choose their portfolio, including their borrowing and lending decisions on the interbank market, to maximize profit subject to regulatory constraints in an asset-liability framework. Systemic risk arises in the form of multiple bank defaults driven by common shock exposure on asset markets, direct contagion via the interbank market, and firesale spirals. The central bank injects or withdraws liquidity on the interbank markets to achieve its desired interest rate target. A tension arises between the beneficial effects of stabilized interest rates and increased loan volume and the detrimental effects of higher risk taking incentives. We find that central bank supply of liquidity quite generally increases systemic risk.
This paper investigates the role of monetary policy in the collapse in the long-term real interest rates in the decade before the onset of the financial crisis using a sample of five advanced economies (United States, United Kingdom, the euro area, Sweden and Canada). The results from an estimated panel VAR with monthly data show that, while monetary policy shocks had negligible effects on long-term real interest rates, shocks to the long-term real interest rates had a one-to-one effect on the short nominal rate.
This paper empirically tests the role of bank lending tightening on non-financial corporate (NFC) bond issuance in the eurozone. By utilizing a unique data set provided by the ECB Bank Lending Survey, we capture the "pure" credit supply effect on corporate external financing. We find that tightened credit standards positively affect the NFC bond issuance: A 1pp increase in banks reporting considerable tightening on loans leads to around a 7% increase in firms' bond issuance in the eurozone. Focusing on a spectrum of aspects contributing to bank credit tightening, we document that banks' balance sheet constraints, as well as the perception of risk lead to significantly higher NFC bond issuance. In addition, we show that stricter lending conditions, such as wider margins, higher collateral requirements and covenants significantly increase NFC bond issuance volumes too. Furthermore, the impact of bank credit tightening on firms' bond issuance is particularly observable in core eurozone countries and not in peripheral countries. This is partially due to the underdeveloped of debt capital markets in the peripheral countries.
This paper investigates the determinants of value and growth investing in a large administrative panel of Swedish residents over the 1999-2007 period. We document strong relationships between a household’s portfolio tilt and the household’s financial and demographic characteristics. Value investors have higher financial and real estate wealth, lower leverage, lower income risk, lower human capital, and are more likely to be female than the average growth investor. Households actively migrate to value stocks over the life-cycle and, at higher frequencies, dynamically offset the passive variations in the value tilt induced by market movements. We verify that these results are not driven by cohort effects, financial sophistication, biases toward popular or professionally close stocks, or unobserved heterogeneity in preferences. We relate these household-level results to some of the leading explanations of the value premium.
We analyze the risk premium on bank bonds at origination with a special focus on the role of implicit and explicit public guarantees and the systemic relevance of the issuing institutions. By looking at the asset swap spread on 5,500 bonds, we find that explicit guarantees and sovereign creditworthiness have a substantial effect on the risk premium. In addition, while large institutions still enjoy lower issuance costs linked to the TBTF framework, we find evidence of enhanced market disciple for systemically important banks which face, since the onset of the financial crisis, an increased premium on bond placements.
We examine the impact of so-called "Crisis Contracts" on bank managers' risk-taking incentives and on the probability of banking crises. Under a Crisis Contract, managers are required to contribute a pre-specified share of their past earnings to finance public rescue funds when a crisis occurs. This can be viewed as a retroactive tax that is levied only when a crisis occurs and that leads to a form of collective liability for bank managers. We develop a game-theoretic model of a banking sector whose shareholders have limited liability, so that society at large will suffer losses if a crisis occurs. Without Crisis Contracts, the managers' and shareholders' interests are aligned, and managers take more than the socially optimal level of risk. We investigate how the introduction of Crisis Contracts changes the equilibrium level of risk-taking and the remuneration of bank managers. We establish conditions under which the introduction of Crisis Contracts will reduce the probability of a banking crisis and improve social welfare. We explore how Crisis Contracts and capital requirements can supplement each other and we show that the efficacy of Crisis Contracts is not undermined by attempts to hedge.
Banks can deal with their liquidity risk by holding liquid assets (self-insurance), by participating in interbank markets (coinsurance), or by using flexible financing instruments, such as bank capital (risk-sharing). We use a simple model to show that undiversifiable liquidity risk, i.e. the liquidity risk that banks are unable to coinsure on interbank markets, represents an important risk factor affecting their capital structures. Banks facing higher undiversifiable liquidity risk hold more capital. We posit that empirically banks that are more exposed to undiversifiable liquidity risk are less active on interbank markets. Therefore, we test for the existence of a negative relationship between bank capital and interbank market activity and find support in a large sample of U.S. commercial banks.
Plus Puls : 2014, 1
(2014)
Background: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) usually presents in middle aged men and shows an indolent clinical behavior. However, up to 30% of the patients present a secondary transformation into aggressive diffuse large B cell lymphoma (DLBCL). The aim of the present study was to characterize morphology and immunophenotype of this kind of DLBCL in detail and compare it with conventional DLBCL.
Methods: Morphology and immunophenotype of 33 cases of NLPHL with simultaneous or sequential transformation into DLBCL were investigated. These cases were compared with 41 de novo DLBCL in Finnish men.
Results: The majority of cases exhibited different immunophenotypes in the NLPHL and the DLBCL components. The immunophenotype of the DLBCL secondary to NLPHL was heterogeneous. However, BCL6, EMA, CD75 and J-chain were usually expressed in both components (≥73% positive). Overall, the NLPHL component was more frequently positive for EMA, CD75 and J-chain than the DLBCL component. In contrast, B cell markers, CD10 and BCL2, were more frequently expressed and were expressed at higher levels in the DLBCL component than in the NLPHL component. In the independent series of de novo DLBCL 4 cases could be identified with a growth pattern and immunophenotype that suggested that they had arisen secondarily from NLPHL.
Conclusions: The morphology and immunophenotype of DLBCL arisen from NLPHL is heterogeneous. Further characterization of the particular molecular features of this subgroup is warranted to be able to better identify these cases among conventional DLBCL.