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Background: In an earlier study we demonstrated the feasibility to create tissue engineered venous scaffolds in vitro and in vivo. In this study we investigated the use of tissue engineered constructs for ureteral replacement in a long term orthotopic minipig model. In many different projects well functional ureretal tissue was established using tissue engineering in animals with short-time follow up (12 weeks). Therefore urothelial cells were harvested from the bladder, cultured, expanded in vitro, labelled with fluorescence and seeded onto the autologous veins, which were harvested from animals during a second surgery. Three days after cell seeding the right ureter was replaced with the cell-seeded matrices in six animals, while further 6 animals received an unseeded vein for ureteral replacement. The animals were sacrificed 12, 24, and 48 weeks after implantation. Gross examination, intravenous pyelogram (IVP), H&E staining, Trichrome Masson's Staining, and immunohistochemistry with pancytokeratin AE1/AE3, smooth muscle alpha actin, and von Willebrand factor were performed in retrieved specimens.
Results: The IVP and gross examination demonstrated that no animals with tissue engineered ureters and all animals of the control group presented with hydronephrosis after 12 weeks. In the 24-week group, one tissue engineered and one unseeded vein revealed hydronephrosis. After 48 weeks all tissue engineered animals and none of the control group showed hydronephrosis on the treated side. Histochemistry and immunohistochemistry revealed a multilayer of urothelial cells attached to the seeded venous grafts.
Comclusions: Venous grafts may be a potential source for ureteral reconstruction. The results of so far published ureteral tissue engineering projects reveal data up to 12 weeks after implantation. Even if the animal numbers of this study are small, there is an increasing rate of hydronephrosis revealing failure of ureteral tissue engineering with autologous matrices in time points longer than 3 months after implantation. Further investigations have to prove adequate clinical outcome and appropriate functional long-term results.
The Neoplastic Room at the Muzeum Sztuki in Łódź was originally designed in 1948 by the avant-garde artist Władysław Strzemiński. Destroyed in 1950 and reconstructed in 1960, it became the focal point of the museum, with the 'International Collection of Modern Art' by the a.r. group being exhibited there. At the same time, it became a point of reference for contemporary artists and a strategy for building a permanent collection for the museum, as well as a reflection on how the past can give a vision of the future. This essay focuses on the gesture of 're-curating' the Neoplastic Room in relation to the performative practice of the artists involved (e.g., Daniel Buren, Elżbieta Jabłońska).
Intersubjetividade e ontologia social nas revisões da teoria do reconhecimento de Axel Honneth
(2017)
O artigo sintetiza as revisões que Axel Honneth impôs a sua obra após a recepção crítica de Luta por reconhecimento (1992), propondo compreendê-las como passos intermediários em direção ao novo modelo crítico apresentado em O direito da liberdade (2011), chamado por Honneth de reconstrução normativa. O objetivo não é examinar as determinações de método da reconstrução normativa, mas percorrer o caminho intelectual de Honneth entre suas duas obras principais, explicitando as revisões e os novos pressupostos da obra “madura” do autor. Essas revisões, concentradas ao redor de uma compreensão considerada por Honneth como mais adequada da intersubjetividade e da ontologia social, escoram e justificam as decisões de método do último livro. Desde o início de sua elaboração teórica, Honneth teve de lidar com a objeção de cometer sistematicamente uma falácia naturalista ao buscar o fulcro de uma teoria crítica da sociedade na experiência concreta do sofrimento. Mesmo Luta por reconhecimento ainda esteve justificadamente sujeito à mesma crítica, como Honneth viria a admitir. Argumento que o objetivo das revisões levadas a cabo na década de 2000 foi sanar essa lacuna, encontrando, por um lado, um índice de racionalidade interno ao próprio ato de reconhecimento, e, por outro, um índice de racionalidade presente nas normas e práticas sociais sedimentadas historicamente por relações de reconhecimento.