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Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation. Pharmacologically enforced egress of hematopoietic stem cells from BM, or mobilization, has been achieved by directly or indirectly targeting the CXCL12/CXCR4 axis. Shortcomings of the standard mobilizing agent, granulocyte colony-stimulating factor (G-CSF), administered alone or in combination with the only approved CXCR4 antagonist, Plerixafor, continue to fuel the quest for new mobilizing agents. Using Protein Epitope Mimetics technology, a novel peptidic CXCR4 antagonist, POL5551, was developed. In vitro data presented herein indicate high affinity to and specificity for CXCR4. POL5551 exhibited rapid mobilization kinetics and unprecedented efficiency in C57BL/6 mice, exceeding that of Plerixafor and at higher doses also of G-CSF. POL5551-mobilized stem cells demonstrated adequate transplantation properties. In contrast to G-CSF, POL5551 did not induce major morphological changes in the BM of mice. Moreover, we provide evidence of direct POL5551 binding to hematopoietic stem and progenitor cells (HSPCs) in vivo, strengthening the hypothesis that CXCR4 antagonists mediate mobilization by direct targeting of HSPCs. In summary, POL5551 is a potent mobilizing agent for HSPCs in mice with promising therapeutic potential if these data can be orroborated in humans.
This is the fifth article in our series Trouble on the Far-Right.
The threat that the far right poses to civil society changes across time and space. In Britain this threat has generally been in the form of hate-crimes and public disorder, yet in the past two decades there has been a shift towards solo-actor terrorism. By examining far right groups in the UK in the post-war period this paper explores the drivers of this change; namely, how membership in extremist groups combined with the proliferation of far right networks created by the internet can create a pathway to radicalisation which ends in acts of terror.
This is the 18. article in our series Trouble on the Far-Right.
When it comes to change in social environments, a parable of philosopher Charles Handy gets pulled out quickly. If you drop a frog in boiling water, it jumps out immediately; but placed in cold water slowly warming up, it acclimates itself and falls to sleep, unaware of being boiled alive. The parable reminds us of the perceptional relativity of change: Within communities creeping developments cause habituation, abrupt breaks an arousing shock. In terms of social movements this truism becomes apparent in a double way: On the one hand, erupting crises may destabilize social orders and create the necessary space for dissident actors to gain momentum – while they would fail to mobilize outside the scenario of an anxious community gasping for a new guarantor of order. On the other hand, the rise of a dissident actor with unconventional performances may work as a shock triggering withdrawal reflexes in the broader society – while dissidents with relative habitual sentiments can find resonance in communities disappointed by the ruling order.
Does this perspective offer a potential to explain the rise of far right movements in Europe? Let’s examine it by the example of Germany where, in the last two years, far right actors have experienced a remarkable gain in political acceptance – on the streets, in the booths and in the talk shows. In this case, it could be argued that their success in protest and electoral mobilizations as well as their disproportionate high presence in the media rests on communication politics that effect a normalization of far right positions previously disreputed in public discourse. Through this creeping habituation by society, they are able to gain momentum in situations of crisis, producing themselves successfully as a legitimate agent of the “anxious citizens” disappointed by the government. To test this little argument, a finger exercise in frame analysis seems to be proper, a tool common in social movement studies to explain why certain ideas in certain contexts are potent to mobilize audiences – and are not in others.
This is the first article in our series Trouble on the Far-Right.
Europe is in trouble. Far right politics is spreading all over the place and its actors and discourses become increasingly influential at various levels: Parties from the far right achieved successes in French, Austrian and Slovakian elections. Far right movement organizations in Germany and Italy mobilized thousands of people to the streets. In Sweden and Great Britain, vigilante and terrorist groups wage armed struggle. And last but not least, ‚illiberal models of democracy‘ in Poland and Hungary demonstrate the far right’s capacity to transform politics on the European level...