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In meinem Vortrag habe ich mich mit den eher technischen Bestimmungen des Referentenentwurfs des Schuldverschreibungsgesetzes zu den Anforderungen an die Beschlüsse der Gläubigerversammlung und vor allem mit ihrer gerichtlichen Kontrolle zu befassen. Diese technischen Fragen lassen sich freilich nicht ganz von den Fragen trennen, die Gegenstand der Referate zu den Befugnissen der Gläubigerversammlung und zu den Anleihebedingungen sind. Ich werde mir also gewisse Grenzüberschreitungen insbesondere auf die Gebiete der zu diesen Themen speziell vorgesehenen Referate zuschulden kommen lassen und bitte hierfür schon jetzt um Nachsicht. Mit Anmerkungen versehene Fassung eines Vortrags auf dem Seminar des Deutschen Aktieninstituts „Die Novellierung des Schuldverschreibungsrechts“ am 16. 9. 2008. Die Vortragsform ist beibehalten.
Background: Polymorphisms within the insulin gene can influence insulin expression in the pancreas and especially in the thymus, where self-antigens are processed, shaping the T cell repertoire into selftolerance, a process that protects from ß-cell autoimmunity.
Methods: We investigated the role of the -2221Msp(C/T) and -23HphI(A/T) polymorphisms within the insulin gene in patients with a monoglandular autoimmune endocrine disease [patients with isolated type 1 diabetes (T1D, n = 317), Addison´s disease (AD, n = 107) or Hashimoto´s thyroiditis (HT, n = 61)], those with a polyglandular autoimmune syndrome type II (combination of T1D and/or AD with HT or GD, n = 62) as well as in healthy controls (HC, n = 275).
Results: T1D patients carried significantly more often the homozygous genotype "CC" -2221Msp(C/T) and "AA" -23HphI(A/T) polymorphisms than the HC (78.5% vs. 66.2%, p = 0.0027 and 75.4% vs. 52.4%, p = 3.7 × 10-8, respectively). The distribution of insulin gene polymorphisms did not show significant differences between patients with AD, HT, or APS-II and HC.
Conclusion: We demonstrate that the allele "C" of the -2221Msp(C/T) and "A" -23HphI(A/T) insulin gene polymorphisms confer susceptibility to T1D but not to isolated AD, HT or as a part of the APS-II.
Poster presentation A central problem in neuroscience is to bridge local synaptic plasticity and the global behavior of a system. It has been shown that Hebbian learning of connections in a feedforward network performs PCA on its inputs [1]. In recurrent Hopfield network with binary units, the Hebbian-learnt patterns form the attractors of the network [2]. Starting from a random recurrent network, Hebbian learning reduces system complexity from chaotic to fixed point [3]. In this paper, we investigate the effect of Hebbian plasticity on the attractors of a continuous dynamical system. In a Hopfield network with binary units, it can be shown that Hebbian learning of an attractor stabilizes it with deepened energy landscape and larger basin of attraction. We are interested in how these properties carry over to continuous dynamical systems. Consider system of the form Math(1) where xi is a real variable, and fi a nondecreasing nonlinear function with range [-1,1]. T is the synaptic matrix, which is assumed to have been learned from orthogonal binary ({1,-1}) patterns ξμ, by the Hebbian rule: Math. Similar to the continuous Hopfield network [4], ξμ are no longer attractors, unless the gains gi are big. Assume that the system settles down to an attractor X*, and undergoes Hebbian plasticity: T´ = T + εX*X*T, where ε > 0 is the learning rate. We study how the attractor dynamics change following this plasticity. We show that, in system (1) under certain general conditions, Hebbian plasticity makes the attractor move towards its corner of the hypercube. Linear stability analysis around the attractor shows that the maximum eigenvalue becomes more negative with learning, indicating a deeper landscape. This in a way improves the system´s ability to retrieve the corresponding stored binary pattern, although the attractor itself is no longer stabilized the way it does in binary Hopfield networks.
Introduction To investigate the predictive value of clinical and biological markers for a pathological complete remission after a preoperative dose-dense regimen of doxorubicin and docetaxel, with or without tamoxifen, in primary operable breast cancer. Methods Patients with a histologically confirmed diagnosis of previously untreated, operable, and measurable primary breast cancer (tumour (T), nodes (N) and metastases (M) score: T2-3(>= 3 cm) N0-2 M0) were treated in a prospectively randomised trial with four cycles of dose-dense (bi-weekly) doxorubicin and docetaxel (ddAT) chemotherapy, with or without tamoxifen, prior to surgery. Clinical and pathological parameters (menopausal status, clinical tumour size and nodal status, grade, and clinical response after two cycles) and a panel of biomarkers (oestrogen and progesterone receptors, Ki-67, human epidermal growth factor receptor 2 (HER2), p53, bcl-2, all detected by immunohistochemistry) were correlated with the detection of a pathological complete response (pCR). Results A pCR was observed in 9.7% in 248 patients randomised in the study and in 8.6% in the subset of 196 patients with available tumour tissue. Clinically negative axillary lymph nodes, poor tumour differentiation, negative oestrogen receptor status, negative progesterone receptor status, and loss of bcl-2 were significantly predictive for a pCR in a univariate logistic regression model, whereas in a multivariate analysis only the clinical nodal status and hormonal receptor status provided significantly independent information. Backward stepwise logistic regression revealed a response after two cycles, with hormone receptor status and lymph-node status as significant predictors. Patients with a low percentage of cells stained positive for Ki-67 showed a better response when treated with tamoxifen, whereas patients with a high percentage of Ki-67 positive cells did not have an additional benefit when treated with tamoxifen. Tumours overexpressing HER2 showed a similar response to that in HER2-negative patients when treated without tamoxifen, but when HER2-positive tumours were treated with tamoxifen, no pCR was observed. Conclusion Reliable prediction of a pathological complete response after preoperative chemotherapy is not possible with clinical and biological factors routinely determined before start of treatment. The response after two cycles of chemotherapy is a strong but dependent predictor. The only independent factor in this subset of patients was bcl-2. Trial registration number NCT00543829
Background This study was carried out to compare the HRQoL of patients in general practice with differing chronic diseases with the HRQoL of patients without chronic conditions, to evaluate the HRQoL of general practice patients in Germany compared with the HRQoL of the general population, and to explore the influence of different chronic diseases on patients HRQoL, independently of the effects of multiple confounding variables. Methods A cross-sectional questionnaire survey including the SF-36, the EQ-5D and demographic questions was conducted in 20 general practices in Germany. 1009 consecutive patients aged 15–89 participated. The SF-36 scale scores of general practice patients with differing chronic diseases were compared with those of patients without chronic conditions. Differences in the SF-36 scale/summary scores and proportions in the EQ-5D dimensions between patients and the general population were analyzed. Independent effects of chronic conditions and demographic variables on the HRQoL were analyzed using multivariable linear regression and polynomial regression models. Results The HRQoL for general practice patients with differing chronic diseases tended to show more physical than mental health impairments compared with the reference group of patients without. Patients in general practice in Germany had considerably lower SF-36 scores than the general population (P < 0.001 for all) and showed significantly higher proportions of problems in all EQ-5D dimensions except for the self-care dimension (P < 0.001 for all). The mean EQ VAS for general practice patients was lower than that for the general population (69.2 versus 77.4, P < 0.001). The HRQoL for general practice patients in Germany seemed to be more strongly affected by diseases like depression, back pain, OA of the knee, and cancer than by hypertension and diabetes. Conclusion General practice patients with differing chronic diseases in Germany had impaired quality of life, especially in terms of physical health. The independent impacts on the HRQoL were different depending on the type of chronic disease. Findings from this study might help health professionals to concern more influential diseases in primary care from the patient´s perspective.
Background: This article reports on the relationship between cultural influences on life style, coping style, and sleep in a sample of female Portuguese immigrants living in Germany. Sleep quality is known to be poorer in women than in men, yet little is known about mediating psychological and sociological variables such as stress and coping with stressful life circumstances. Migration constitutes a particularly difficult life circumstance for women if it involves differing role conceptions in the country of origin and the emigrant country.
Methods: The study investigated sleep quality, coping styles and level of integration in a sample of Portuguese (N = 48) and Moroccan (N = 64) immigrant women who took part in a structured personal interview.
Results: Sleep quality was poor in 54% of Portuguese and 39% of Moroccan women, which strongly exceeds reports of sleep complaints in epidemiologic studies of sleep quality in German women. Reports of poor sleep were associated with the degree of adoption of a German life style. Women who had integrated more into German society slept worse than less integrated women in both samples, suggesting that non-integration serves a protective function. An unusually large proportion of women preferred an information-seeking (monitoring) coping style and adaptive coping. Poor sleep was related to high monitoring in the Portuguese but not the Moroccan sample.
Conclusion: Sleep quality appears to be severely affected in women with a migration background. Our data suggest that non-integration may be less stressful than integration. This result points to possible benefits of non-integration. The high preference for an information-seeking coping style may be related to the process of migration, representing the attempt at regaining control over an uncontrollable and stressful life situation.
The goal of this paper is to re-examine the status of the condition in (1) proposed in Alexiadou and Anagnostopoulou (2001; henceforth A&A 2001), in view of recent developments in syntactic theory. (1) The subject-in-situ generalization (SSG) By Spell-Out, vP can contain only one argument with a structural Case feature. We argue that (1) is a more general condition than previously recognized, and that the domain of its application is parametrized. More specifically, based on a comparison between Indo-European (IE) and Khoisan languages, we argue that (1) supports an interpretation of the EPP as a general principle, and not as a property of T. Viewed this way, the SSG is a condition that forces dislocation of arguments as a consequence of a constraint on Case checking.
In this paper we compare the distribution of PPs introducing external arguments in nominalizations with PPs introducing external arguments in the verbal domain. We show that several mismatches exist between the behavior of PPs in nominalizations and PPs in the verbal domain. This leads us to suggest that while PPs in the verbal domain are licensed by functional structure alone, within the nominal domain, PPs can also be licensed via an interplay of the encyclopaedic meaning of the root involved and the properties of the preposition itself. This second mechanism kicks in in the absence of functional structure.
Structuring participles
(2008)
In this paper we discuss three types of adjectival participles in Greek, ending in -tos and –menos, and provide a further argument for the view that finer distinctions are necessary in the domain of participles (Kratzer 2001, Embick 2004). We further compare Greek stative participles to their German (and English) counterparts. We propose that a number of semantic as well as syntactic differences shown by these derive from differences in their respective morpho-syntactic composition.
In this paper we investigate the distribution of PPs related to external arguments (agent, causer, instrument, causing event) in Greek. We argue that their distribution supports an analysis, according to which agentive/instrument and causer PPs are licensed by distinct functional heads, respectively. We argue against a conceivable alternative analysis, which links agentivity and causation to the prepositions themselves. We furthermore identify a particular type of Voice head in Greek anticausative realised by non-active Voice morphology.
In the recent literature there is growing interest in the morpho-syntactic encoding of hierarchical effects. The paper investigates one domain where such effects are attested: ergative splits conditioned by person. This type of splits is then compared to hierarchical effects in direct-inverse alternations. On the basis of two case studies (Lummi instantiating an ergative split person language and Passamaquoddy an inverse language) we offer an account that makes no use of hierarchies as a primitive. We propose that the two language types differ as far as the location of person features is concerned. In inverse systems person features are located exclusively in T, while in ergative systems, they are located in T and a particular type of v. A consequence of our analysis is that Case checking in split and inverse systems is guided by the presence/absence of specific phi-features. This in turn provides evidence for a close connection between Case and phi-features, reminiscent of Chomsky’s (2000, 2001) Agree.
On the role of syntactic locality in morphological processes : the case of (Greek) derived nominals
(2008)
The paper is structured as follows. In section 2, I briefly summarize the facts on English and Greek nominalizations. In section 3, I discuss English nominal derivation in some detail. In section 4, I turn to the question of licensing of AS in nominals. In section 5, I turn to the issue of the optionality of licensing of AS in the nominal system.
The causative/anticausative alternation has been the topic of much typological and theoretical discussion in the linguistic literature. This alternation is characterized by verbs with transitive and intransitive uses, such that the transitive use of a verb V means roughly "cause to Vintransitive" (see Levin 1993). The discussion revolves around two issues: the first one concerns the similarities and differences between the anticausative and the passive, and the second one concerns the derivational relationship, if any, between the transitive and intransitive variant. With respect to the second issue, a number of approaches have been developed. Judging the approach conceptually unsatisfactory, according to which each variant is assigned an independent lexical entry, it was concluded that the two variants have to be derivationally related. The question then is which one of the two is basic and where this derivation takes place in the grammar. Our contribution to this discussion is to argue against derivational approaches to the causative / anticausative alternation. We focus on the distribution of PPs related to external arguments (agent, causer, instrument, causing event) in passives and anticausatives of English, German and Greek and the set of verbs undergoing the causative/anticausative alternation in these languages. We argue that the crosslinguistic differences in these two domains provide evidence against both causativization and detransitivization analyses of the causative / anticausative alternation. We offer an approach to this alternation which builds on a syntactic decomposition of change of state verbs into a Voice and a CAUS component. Crosslinguistic variation in passives and anticausatives depends on properties of Voice and its combinations with CAUS and various types of roots.
This paper deals with the variable position of adjectives in the Romanian DP. As all other Romance languages, Romanian allows for adjectives to appear in both prenominal and post-nominal position. In addition, however, Romanian has a third pattern: the so-called cel construction, in which the adjective in the post-nominal position is preceded by a determiner-like element, cel. This pattern is superficially similar to Determiner Spreading in Greek. In this paper we contrast the cel construction to Greek DS and discuss the similarities and differences between the two. We then present an analysis of cel as involving an appositive specification clause, building on de Vries (2002). We argue that the same structure is also involved in the context of nominal ellipsis, the second environment in which cel is found.
Die Forschung zur Rolle und zum Anteil von Frauen in der Geschichte der Literatur hat sich in den letzten Jahrzehnten rasant entwickelt und damit begonnen, ihr Profil weiter aufzufachern. Sie hat dabei inzwischen einen hohen Standard erreicht. Allerdings klaffen die Komplexität der Theorien, die literaturhistorische Praxis und die häufig immer noch schlecht dokumentierte und daher, im Verhältnis zum Vorhandenen, kleine Materialbasis immer stärker auseinander, obwohl zu den vielen Publikationen der letzten Jahre auch eine Reihe von Bestandsaufnahmen und literaturhistorischen Studien, Literaturlexika und Datenbanken gehört, die sich mit Frauen als Autorinnen beschäftigen. Im Zentrum dieser Arbeiten stehen die Suche nach vergessenen, verdrängten undJoder nie wahrgenommenen Autorinnen und Texten, die Biographien von Autorinnen unter Einschluss der bibliographischen wie faktischen Sicherung der Texte und die Beschreibung der Rolle von Autorinnen iin Literaturbetrieb ihrer Zeit.
Wenn sich diese Untersuchung mit Lexika zu Schriftstellerinnen im deutschsprachigen Raum beschäftigt, so beinhaltet diese Themenstellung mehrere Eingrenzungen. Thema sind hier Lexika, die speziell und ausschließlich weibliche Autoren behandeln. Innerhalb dessen erfolgte eine Beschränkung auf Schriftstellerinnen im deutschsprachigen Raum Dabei wird als Schriftstellerinnenlexikon hier ein Werk definiert, das - in alphabetischer Reihenfolge nach Namen geordnet - biographische und bibliographische Informationen zu Schriftstellerinnen enthält.
A commonly held view in the literature on Scrambling and Clitic Doubling is that both constructions are sensitive to Specificity. For this reason Sportiche (1992) proposes to unify the two, an approach which has become quite standard in the relevant literature ever since. However, the claim that clitic doubling is the counterpart of Germanic scrambling has never been substantiated. In this paper we present extensive evidence from Greek that Clitic Doubling has common formal properties with Germanic Scrambling/Object Shift. Our evidence consists mainly of binding facts observed when doubling takes place, which seem, at first sight, to be completely unexpected. On closer inspection, however, it turns out that these facts are strongly reminiscent of the effects showing up in Germanic scrambling. We propose that these properties can be derived under a theory of clitic constructions along the lines of Sportiche (1992) implemented into the framework of Chomsky (1995). Finally we suggest the that the crosslinguistic distribution of Scrambling as opposed to Clitic Doubling should be linked to a parameter relating to properties of Agr: Move/Merge XP vs. Move/Merge X° to Agr. We show that this parameter unifies the behaviour of subjects and objects within a language and across languages. The paper is organised as follows. In section 2 we present evidence from binding, interpretational and prosodic effects that doubling and scrambling display very similar properties. In section 3 we present Sportiches account and point out some problems for it. In section 4 we present our proposal.
Der Elsassische Patriot. Erster Jahrgang 1776 : eine Wochenschrift zum Unterricht für alle Stände
(1776)
Julius Stockhausen (1826 - 1906) war als Oratorien- und Konzertsänger, ebenso auch als Gesangspädagoge weltberühmt. Seit 1878 lebte er in Frankfurt, zunächst als Lehrer am Hochschen Konservatorium, dann als Leiter einer eigenen Gesangsschule. Die wertvollsten Teile seines Nachlasses, vor allem die Musikautographen, wurden nach Stockhausens Tod durch eine Auktion verstreut. Dagegen blieben annähernd 850 Briefe von einem weiten Personenkreis des europäischen Musiklebens an Stockhausen zunächst im Familienbesitz erhalten; ebenso seine Familienkorrespondenz, die Tagebücher, Konzertprogramme und ein erlesener Bestand mit Musikdrucken. Der handschriftliche Bestand konnte um 1957 von unserer Bibliothek erworben werden, die Druckwerke waren bereits vor 1945 in die Rothschildsche Bibliothek gelangt.