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- Epilepsy (17)
- Escola de Frankfurt (17)
- Essay (17)
- Etymologie (17)
- Fagus sylvatica (17)
- Fehler (17)
- Filmographie (17)
- Florida (17)
- Französische Revolution (17)
- Freie Gewerkschaft (17)
- Frühe Neuzeit (17)
- Frühneuhochdeutsch (17)
- Genetics (17)
- Grillparzer, Franz (17)
- Gutzkow, Karl (17)
- Horrorfilm (17)
- Industriearbeiterin (17)
- Islamismus (17)
- Judentum (17)
- Kajkavisch (17)
- Kapitalmarktrecht (17)
- Komödie (17)
- Lewald, Fanny (17)
- Methode (17)
- Mundart (17)
- Natur <Motiv> (17)
- Nearctic (17)
- Oesterle, Günter (17)
- Photographie (17)
- Portugal (17)
- Presse (17)
- Professionalisierung (17)
- Pronomen (17)
- Präposition (17)
- Rezensionen (17)
- Schriftstellerin (17)
- Schule (17)
- Shakespeare, William (17)
- Social System (17)
- Spieltheorie (17)
- Sprachkritik (17)
- Stilistik (17)
- Student (17)
- Synergie (17)
- Tabu (17)
- Teoria crítica (17)
- Textverstehen (17)
- Turkey (17)
- Vielfalt (17)
- Wertpapieremission (17)
- Wettbewerb (17)
- climate (17)
- gene therapy (17)
- glioma (17)
- host plants (17)
- mortality (17)
- parasitoid (17)
- schizophrenia (17)
- stroke (17)
- tumor microenvironment (17)
- vegetation classification (17)
- Adverb (16)
- Angiogenesis (16)
- Anthologie (16)
- Biomarkers (16)
- Caribbean (16)
- CiNyungwe (16)
- Distribution (16)
- EBA (16)
- Euro (16)
- Finanzwirtschaft (16)
- Fiscal Policy (16)
- Gene expression (16)
- Genossenschaftsbewegung (16)
- Gesprochene Sprache (16)
- Gewerkverein der Heimarbeiterinnen Deutschlands für Kleider- und Wäschekonfektion und verwandte Berufe (1900-) (16)
- Gleichberechtigung (16)
- Grammatikalisation (16)
- Grass, Günter (16)
- Hausarbeit (16)
- Hegel, Georg Wilhelm Friedrich (16)
- Herrschaft (16)
- Industriearbeit (16)
- Infektionsabwehr (16)
- Infrarot (16)
- Journalismus (16)
- Kollokation (16)
- Koti (16)
- Kreditwesen (16)
- Krim (16)
- Marx, Karl (16)
- Memory (16)
- Migration <Motiv> (16)
- Modellierung (16)
- Mähren (16)
- Müller, Heiner (16)
- Nibelungenlied (16)
- Nordrhein-Westfalen (16)
- Nyungwe (16)
- Open Access (16)
- Outcome (16)
- Prostitution (16)
- Pädagogik (16)
- Relativistic heavy-ion collisions (16)
- Selbstdarstellung (16)
- Sicherheit (16)
- Sicherheitspolitik (16)
- Sprachpolitik (16)
- Sprachstatistik (16)
- Surgery (16)
- Synthesis (16)
- Systematics (16)
- Terminologie (16)
- Transparenz (16)
- Transylvanian Saxons (16)
- Ungarisch (16)
- Unternehmen (16)
- Vergleich (16)
- Wahlkampf (16)
- Wirklichkeit (16)
- Zeitung (16)
- asset pricing (16)
- cryptic species (16)
- culture (16)
- financial stability (16)
- inflation (16)
- memory (16)
- miRNA (16)
- new genera (16)
- ordination (16)
- phenology (16)
- populism (16)
- proteomics (16)
- terrorism (16)
- uncertainty (16)
- word order (16)
- Ägypten (16)
- ALICE (15)
- Alphabetisierung (15)
- Altgermanistik (15)
- Arbeitslosigkeit (15)
- Asia (15)
- Außenpolitik (15)
- Bildnis (15)
- Börne, Ludwig (15)
- Carabidae (15)
- Chuwabu (15)
- Cirrhosis (15)
- Contagion (15)
- Culture (15)
- Das Ganze (15)
- Datenschutz (15)
- EKoti (15)
- Echuwabo (15)
- Erzählforschung (15)
- Finanzierung (15)
- France (15)
- Fußball (15)
- Gefühl <Motiv> (15)
- Geschichte 1800-1900 (15)
- Grammatiktheorie (15)
- Historismus (15)
- Hochschuldidaktik (15)
- Hochschule (15)
- Hymenoptera (15)
- ISIS (15)
- Ideologie (15)
- Immunology (15)
- Indogermanische Sprachen (15)
- Interkulturelles Lernen (15)
- Konsumgenossenschaft (15)
- Korruption (15)
- Kritische Theorie (15)
- Kulturanthropologie (15)
- Kulturwissenschaft (15)
- Kulturwissenschaftliche Bibliothek Warburg (15)
- Landarbeiterin (15)
- Lehrbuch (15)
- Lepidoptera (15)
- Literaturgeschichte (15)
- Macht (15)
- Maschinelle Übersetzung (15)
- Mimesis (15)
- Mitgliederwerbung (15)
- Morphosyntax (15)
- Muttersprache (15)
- Nachhaltigkeit (15)
- Nationalbewusstsein (15)
- Nominalphrase (15)
- Obama (15)
- Palaearctic (15)
- Pension Insurance (15)
- Politische Verfolgung (15)
- Preußen (15)
- Prophetie (15)
- Protest (15)
- QCD (15)
- QGP (15)
- Quantitative Easing (15)
- Sarawak (15)
- Simulation (15)
- Solvency II (15)
- Sprechakt (15)
- Stadt <Motiv> (15)
- Topikalisierung (15)
- Twitter (15)
- Verlag (15)
- Wahlagitation (SPD) (15)
- Warburg, Aby Moritz (15)
- Westafrika (15)
- Wiederholung (15)
- Wikileaks (15)
- Wolf, Christa (15)
- X-ray crystallography (15)
- endothelial cells (15)
- gene expression (15)
- heavy-ion collisions (15)
- hippocampus (15)
- human rights (15)
- introduced species (15)
- key to species (15)
- mass spectrometry (15)
- multiple sclerosis (15)
- obesity (15)
- oxidative stress (15)
- parasitoids (15)
- recognition (15)
- reduction of pain (15)
- structural biology (15)
- systemic risk (15)
- temperature (15)
- teoria crítica (15)
- tissue oxygen partial pressure (15)
- tissue temperature (15)
- treatment (15)
- Agamben, Giorgio (14)
- Anglizismus (14)
- Arabisch (14)
- Arbeitsgemeinschaft Sammlung Deutscher Drucke (14)
- Artikulatorische Phonetik (14)
- Asset Pricing (14)
- Aussprache (14)
- Australia (14)
- Barock (14)
- Biogeography (14)
- Bitcoin (14)
- Bürgertum (14)
- Chewa-Sprache (14)
- Children (14)
- Chwabo (14)
- DNA (14)
- Demography (14)
- Döblin, Alfred (14)
- ESR Spectra (14)
- Epistemologie (14)
- Epoche (14)
- Erzählperspektive (14)
- European Central Bank (14)
- Flüchtlinge (14)
- Form (14)
- Fortschritt (14)
- Frieden (14)
- Gattungstheorie (14)
- Gegenwart (14)
- Genossenschaft (14)
- Gentherapie (14)
- Geschichte 1801-1870 (14)
- Griechenland (14)
- Habermas (14)
- Hadron (14)
- Held (14)
- Homosexualität (14)
- Humanismus (14)
- Indien (14)
- Infrastruktur (14)
- Inszenierung (14)
- Interrogativsatz (14)
- Israel (14)
- Jean Paul (14)
- Joyce, James (14)
- Kapitalmarkt (14)
- Kindersprache (14)
- Klima (14)
- Kommentar (14)
- Lernen (14)
- Literarische Gestalt (14)
- Literarische Übersetzung (14)
- Ludwig (14)
- Magnetic resonance imaging (14)
- Mathematik (14)
- Molinio-Arrhenatheretea (14)
- Mortality (14)
- Mörike, Eduard (14)
- Mündlichkeit (14)
- Nachkriegszeit (14)
- Nachlass (14)
- New Zealand (14)
- New species (14)
- Nungisch (14)
- Parodie (14)
- Pension (14)
- Philhellenismus (14)
- Reformation (14)
- Risikomanagement (14)
- Russia (14)
- Sauerstoffversorgung (14)
- Schwedisch (14)
- Schönheit (14)
- Slowakisch (14)
- South Africa (14)
- Spitteler, Carl (14)
- Sprachvariante (14)
- Sprachverstehen (14)
- Sprichwort (14)
- Strategie (14)
- Subjektivität (14)
- Taxonomie (14)
- Terror (14)
- Topographie <Kulturwissenschaft> (14)
- Transformation (14)
- Trauma (14)
- Vokal (14)
- Wagner, Richard (14)
- Walther <von der Vogelweide> (14)
- Widerstand (14)
- Wissenschaftskommunikation (14)
- Wortschatz (14)
- banking (14)
- credit risk (14)
- epigenetics (14)
- eutrophication (14)
- extracellular matrix (14)
- financial crisis (14)
- flora (14)
- focus (14)
- insurance (14)
- interculturality (14)
- lectotype (14)
- macrophages (14)
- planthopper (14)
- radical prostatectomy (14)
- tissue blood flow (14)
- ubiquitination (14)
- wound healing (14)
- Analyse (13)
- Andes (13)
- Apoidea (13)
- Ausländer (13)
- Bachtin, Michail M. (13)
- Barbar <Motiv> (13)
- Bayern (13)
- Biopolitik <Motiv> (13)
- Borges, Jorge Luis (13)
- Bourdieu, Pierre (13)
- Capsule endoscopy (13)
- Clearing (13)
- Cognition (13)
- Croatian language (13)
- Cryptocurrency (13)
- Das Andere (13)
- Deutschlehrer (13)
- Ding <Motiv> (13)
- Ecocriticism (13)
- Ecuador (13)
- Energie (13)
- Epigenetik (13)
- Faschismus (13)
- Filmtheorie (13)
- Finanzkrise (13)
- Fremdbild (13)
- Gesicht <Motiv> (13)
- Großstadt <Motiv> (13)
- Habitat (13)
- Handel (13)
- Heinrich von (13)
- Herder (13)
- Herwegh, Georg (13)
- Identity (13)
- Immunotherapy (13)
- Karikatur (13)
- Kasus (13)
- Kinder- und Hausmärchen (13)
- Kinderschutz (13)
- Klein- und Mittelbetrieb (13)
- Kompositum (13)
- Kreativität (13)
- Kulturpolitik (13)
- Lehrmittel (13)
- Literaturkanon (13)
- Machine Learning (13)
- Mammakarzinom (13)
- Medientheorie (13)
- Middle East (13)
- Moral (13)
- Motivation (13)
- Multikulturelle Gesellschaft (13)
- Multistable figures (13)
- Museum (13)
- NADPH oxidase (13)
- Nation (13)
- Negation (13)
- Neoliberalismus (13)
- Netzpolitik (13)
- Oncology (13)
- Oriental Region (13)
- Parkinson’s disease (13)
- Paul (13)
- Performativität <Kulturwissenschaften> (13)
- Phylogeny (13)
- Possessivität (13)
- Prag (13)
- Predigt (13)
- R2P (13)
- ROS (13)
- Radiotherapy (13)
- Rezeptionsästhetik (13)
- Rothacker, Erich (13)
- Römisches Reich (13)
- Saving (13)
- Schrift (13)
- Screening (13)
- Souveränität (13)
- Sozialer Wandel (13)
- Spanien (13)
- Sprachgebrauch (13)
- Sprachkompetenz (13)
- Sprachlehrbuch (13)
- Suttner, Bertha von (13)
- Tagalog (13)
- Transylvania (13)
- Ungarn (13)
- Vergangenheitsbewältigung (13)
- Vergesellschaftung (13)
- Verkehr (13)
- Vertrauen (13)
- Volkserzählung (13)
- Weiblichkeit (13)
- Zeitgenössische Kunst (13)
- bladder cancer (13)
- caves (13)
- child (13)
- cirrhosis (13)
- communication (13)
- cytokines (13)
- endemic (13)
- epidemiology (13)
- fiscal policy (13)
- fungi (13)
- genitalia (13)
- globalization (13)
- hrvatski jezik (13)
- ideology (13)
- islamic state (13)
- liquidity (13)
- lung cancer (13)
- meiofauna (13)
- metabolism (13)
- neurodegeneration (13)
- red riječi (13)
- review (13)
- signal transduction (13)
- species delimitation (13)
- spider (13)
- survival (13)
- synaptic plasticity (13)
- Öffentlichkeit (13)
- ABS (12)
- Aesthetics (12)
- Afghanistan (12)
- Allegorie (12)
- Anti-Utopie (12)
- Arbeiterinnenfrage (12)
- Arbeiterinnenverein (12)
- Argentina (12)
- Asymmetrische Information (12)
- Bank Lending (12)
- Behavior (12)
- Berliner Kindheit um neunzehnhundert (12)
- Buch (12)
- Bulgarisch (12)
- Börsenrecht (12)
- Bürgerliche Frauenbewegung (12)
- Chronotopos (12)
- Comments disabled (12)
- Computerspiel (12)
- Consumption (12)
- Cryoelectron microscopy (12)
- Datenbank (12)
- Deutsches Sprachgebiet (12)
- Diagnostik (12)
- Divina Commedia (12)
- Ecology (12)
- Einfühlung (12)
- Endothelial cells (12)
- England (12)
- Epidemiology (12)
- Familienname (12)
- Faust (12)
- Florenz (12)
- Frauenliteratur (12)
- George, Stefan (12)
- Germanist (12)
- Geschichte 1450-1650 (12)
- Geschlechterverhältnis (12)
- Gewalt <Motiv> (12)
- Greece (12)
- Grundschule (12)
- HCV (12)
- Heros (12)
- Historische Sprachwissenschaft (12)
- History (12)
- Idealisierung (12)
- Intellektueller (12)
- Investmentfonds (12)
- Kamerun (12)
- Kapitalertrag (12)
- Katastrophe <Motiv> (12)
- Kleidung (12)
- Klimaänderung (12)
- Kommunismus (12)
- Konsonant (12)
- Kopula (12)
- Krise (12)
- Lexikografie (12)
- Luther, Martin (12)
- Massenmedien (12)
- Membranproteine (12)
- MiFID II (12)
- Militär (12)
- Modalverb (12)
- Myanmar (12)
- NMR-Spektroskopie (12)
- Namibia (12)
- Nationalsozialismus <Motiv> (12)
- Neuer Markt (12)
- Neugriechisch (12)
- Pandemie (12)
- Paratext (12)
- Personenname (12)
- Pinus sylvestris (12)
- Portfolio Selection (12)
- Portugiesisch / Brasilien (12)
- Private Investment (12)
- Proust, Marcel (12)
- Psychologie (12)
- Publizistik (12)
- Rechtsradikalismus (12)
- Referenzidentität (12)
- Reise (12)
- Repräsentation (12)
- Revolution (12)
- Rheinland-Pfalz (12)
- Romania (12)
- Rumänien (12)
- Sage (12)
- Sehen (12)
- Semantics (12)
- Sozialgeschichte (12)
- Spannung (12)
- Stadtentwicklung (12)
- Standardsprache (12)
- Struktur (12)
- Subjekt (12)
- Suffix (12)
- Suicide (12)
- Tanz (12)
- Tempus (12)
- Theodor Adorno (12)
- Topik (12)
- Training (12)
- Transfer (12)
- United States (12)
- Vendée (France) (12)
- Verbreitung (12)
- Vereinte Nationen (12)
- Walser, Robert (12)
- Wirtschaftssprache (12)
- Zeit <Motiv> (12)
- Zustandsgleichung (12)
- alien species (12)
- alphabetisation (12)
- artificial intelligence (12)
- barcoding (12)
- cell death (12)
- colorectal cancer (12)
- disturbance (12)
- dry grassland (12)
- financial literacy (12)
- first record (12)
- health (12)
- human (12)
- language (12)
- leukemia (12)
- mouse (12)
- orthography (12)
- prevalence (12)
- restoration (12)
- risk (12)
- semantics (12)
- simulation (12)
- spiders (12)
- stress (12)
- surgery (12)
- syntax (12)
- validity (12)
- Ableitung <Linguistik> (11)
- Adjunkt <Linguistik> (11)
- Aktivismus (11)
- Alphabet (11)
- Ambiguität (11)
- Arbeitsmarkt (11)
- Arbeitsmarktpolitik (11)
- Arzneimittel (11)
- Aspekt (11)
- Auslandsgermanistik (11)
- Autophagy (11)
- Bioenergetics (11)
- Bloch, Ernst (11)
- Bolivia (11)
- Bryophytes (11)
- Bundesverfassungsgericht (11)
- Börsenordnung (11)
- Canguilhem, Georges (11)
- Cerambycidae (11)
- Chatten <Kommunikation> (11)
- Chemotherapy (11)
- Cisena (11)
- Computerphilologie (11)
- Czech Republic (11)
- Derivatives (11)
- Deutsch als Zweitsprache (11)
- Diabetes mellitus (11)
- Dienstmädchen (11)
- Diplomatie (11)
- Diskriminierung (11)
- Dissertation (11)
- Dokumentation (11)
- Droste-Hülshoff, Annette von (11)
- Dürrenmatt, Friedrich (11)
- EIOPA (11)
- Einkommensverteilung (11)
- Emotions (11)
- Endoscopy (11)
- Europäische Zentralbank (11)
- Evangelischer Arbeiterinnenverein (11)
- Federal Reserve (11)
- Freundschaft (11)
- Geburtenregelung (11)
- Geschichte <Motiv> (11)
- Globalization (11)
- Grimm, Wilhelm (11)
- Guatemala (11)
- Hadron-Hadron scattering (experiments) (11)
- Hegel (11)
- Heidegger, Martin (11)
- Hofmannsthal (11)
- Imagination (11)
- In vitro (11)
- Inversionsfigur (11)
- Italienbild (11)
- Jahrhundertwende (11)
- Jesus Christus (11)
- Joseph von (11)
- Jürgen Habermas (11)
- Konnotation (11)
- Kontrastive Phraseologie (11)
- Kredit (11)
- Kulturvermittlung (11)
- Kurzgeschichte (11)
- Lacan, Jacques (11)
- Legende (11)
- Leidenschaft (11)
- Life Insurance (11)
- Literaturgattung (11)
- Low Interest Rates (11)
- Makonde-Sprache (11)
- Mali (11)
- Mediterranean (11)
- Melancholie (11)
- Menschenrechte (11)
- Molecular biology (11)
- Mollusca (11)
- Mutterschaft (11)
- Mutterschaftsversicherung (11)
- Optionspreistheorie (11)
- Ovidius Naso, Publius (11)
- Peter (11)
- Peter Tauber (11)
- Politische Bildung (11)
- Pop-Kultur (11)
- Preis <Auszeichnung> (11)
- Primary care (11)
- Psychology (11)
- Quark Gluon Plasma (11)
- Quark-Gluon Plasma (11)
- RHIC (11)
- Rechtssprache (11)
- Rousseau, Jean-Jacques (11)
- Saccharomyces cerevisiae (11)
- Schizophrenia (11)
- Schutzverantwortung (11)
- Selbstbild (11)
- Sena (11)
- Silbe (11)
- TLAC (11)
- Textgeschichte (11)
- Theatertheorie (11)
- Tieck, Ludwig (11)
- Tiere <Motiv> (11)
- Transkulturalität (11)
- Uncertainty (11)
- VEGF (11)
- Verfassung (11)
- Verfilmung (11)
- Wahrnehmungswechsel (11)
- Waldgesellschaften (11)
- Weerth, Georg (11)
- Wohnverhältnisse (11)
- Wortfeld (11)
- Zeichen (11)
- Zweig, Stefan (11)
- al-Qaida (11)
- asymmetric information (11)
- bees (11)
- crisis (11)
- forest management (11)
- grammar (11)
- grazing (11)
- habitat (11)
- hydrogen bonding (11)
- integrins (11)
- intercultural communication (11)
- justice (11)
- macrophage polarization (11)
- magnetic resonance imaging (11)
- male genitalia (11)
- metastasis (11)
- model uncertainty (11)
- new synonym (11)
- outcome (11)
- p53 (11)
- participation (11)
- physical activity (11)
- psoriasis (11)
- public debt (11)
- quark gluon plasma (11)
- radiotherapy (11)
- real-time data (11)
- responsibility (11)
- risk factors (11)
- targeted therapy (11)
- transparency (11)
- vegetation (11)
- Ästhetische Wahrnehmung (11)
- Österreich-Ungarn (11)
- Überwachung (11)
- 19. Jahrhundert (10)
- 5-lipoxygenase (10)
- ACLF (10)
- Achtundsechziger (10)
- Aktienkurs (10)
- Alzheimer’s disease (10)
- Anthrozoologie (10)
- Arbeit <Motiv> (10)
- Arbeitsrecht (10)
- Arbeitsverhältnisse (10)
- Archivierung (10)
- Asset Allocation (10)
- Autor (10)
- Bankenaufsicht (10)
- Barrierefreiheit (10)
- Barthes, Roland (10)
- Baudelaire, Charles (10)
- Big Data (10)
- Bildungsroman (10)
- Biopolitik (10)
- Boko Haram (10)
- Bratoljub Klaić (10)
- Brustkrebs (10)
- Bundestag (10)
- C. elegans (10)
- CDU (10)
- COPD (10)
- Chile (10)
- Conservation (10)
- Costa Rica (10)
- Cyberwar (10)
- Deutsch-Ostafrika (10)
- Diagnostic markers (10)
- Dialektik (10)
- Ding (10)
- Disclosure (10)
- Disticha Catonis (10)
- Diversity (10)
- EGFR (10)
- Educação (10)
- Egypt (10)
- Eichendorff (10)
- Einkommen (10)
- Ellenberg indicator values (10)
- Energieumsatz <Medizin> (10)
- Entstehung (10)
- Erlebnisbericht (10)
- Evolutionspsychologie (10)
- Facebook (10)
- Fachinformationsdienst (10)
- Fauna (10)
- Fintech (10)
- Fragebogen (10)
- Frankfurt / Universität (10)
- Frankfurt <Main> / Universität / Poelzig-Bau (10)
- Frauenpolitik (SPD) (10)
- Frauenpresse (10)
- Freedom (10)
- GARCH-Prozess (10)
- Geld (10)
- Geld <Motiv> (10)
- Generative Grammatik (10)
- Gerechtigkeit (10)
- Germanistenverband (10)
- Geschichtsbild (10)
- Gesundheitswesen (10)
- Grenze (10)
- Hamburg (10)
- Heart failure (10)
- Heavy-ion collisions (10)
- Hepatocellular carcinoma (10)
- Humor (10)
- IR Spectra (10)
- Immunologie (10)
- Inclusion (10)
- Integriertes Lernen (10)
- Investor Protection (10)
- Ionenstrahl (10)
- Jiddisch (10)
- Joachim Wittstock (10)
- Jugendsprache (10)
- Justice (10)
- Kapitalmarkteffizienz (10)
- Kinderarbeit (10)
- Klitisierung (10)
- Knowledge (10)
- Kolumbien (10)
- Kommunikationsanalyse (10)
- Konfektion (10)
- Kontext (10)
- Konzentrationslager (10)
- Kooperation (10)
- Koreanisch (10)
- Kracauer, Siegfried (10)
- Kubrick, Stanley (10)
- Kuratieren (10)
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- Learning (10)
- Legitimation (10)
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- Recht <Motiv> (10)
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- Romantheorie (10)
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- Anapher <Syntax> (9)
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- Armut <Motiv> (9)
- Art (9)
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- Nationalsozialistische Deutsche Arbeiterpartei (NSDAP, 1920-) (8)
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- geographic distribution (8)
- harvestmen (8)
- hereditary angioedema (8)
- identification keys (8)
- inclusion (8)
- information structure (8)
- intraspecific variation (8)
- introduction (8)
- invasive (8)
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- sphingolipids (8)
- sustainability (8)
- taxonomic key (8)
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- transfer (8)
- ubiquitin (8)
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- Äquivalenz (8)
- 500-1500 (7)
- Ackerunkräuter (7)
- Adaptation (7)
- Aktiengesellschaft (7)
- Aktionär (7)
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- Basidiomycota (7)
- Bayesian estimation (7)
- Behinderung (7)
- Belize (7)
- Beuys, Joseph (7)
- Biological invasions (7)
- Biophysical chemistry (7)
- Black holes (7)
- Bobrowski, Johannes (7)
- Borrelia (7)
- Brandenburg (7)
- Bremen (7)
- Brüder Grimm (7)
- CRISPR/Cas9 (7)
- Cancer treatment (7)
- Capital-Asset-Pricing-Modell (7)
- Cerrado (7)
- Charakterisierung (7)
- Chemiker (7)
- Chewa (7)
- Chichewa (7)
- Christliche Arbeiterbewegung (7)
- Colorectal cancer (7)
- Corporate Social Responsibility (7)
- Culicidae (7)
- Curculionidae (7)
- Cyanobacteria (7)
- Das Böse (7)
- Das Heilige (7)
- Das Sakrale (7)
- Data processing (7)
- Data science (7)
- Deflation (7)
- Derivat, Wertpapier (7)
- Deutscher Einwanderer (7)
- Deutschland / Vereinigung (7)
- Deutschland <Bundesrepublik> (7)
- Deutschland <DDR> / Revolution <1989> (7)
- Deutschlandbild (7)
- Development (7)
- Diagnose (7)
- Dienstmädchenverein (7)
- Digital Rights (7)
- Digital Services Act (7)
- Dodd-Frank Act (7)
- Drogenkonsum (7)
- Drogenszene (7)
- Drung (7)
- EZB (7)
- Eastern Arc (7)
- Eco, Umberto (7)
- Electroencephalography (7)
- Elektronische Bibliothek (7)
- Empfindsamkeit (7)
- Empirische Ästhetik (7)
- Engel <Motiv> (7)
- Enzensberger, Hans Magnus (7)
- Epigenetics (7)
- Episches Theater (7)
- Epos (7)
- Erwerbslosigkeit (7)
- Essayismus (7)
- Ethica ordine geometrico demonstrata (7)
- Ethnizität (7)
- Euro Area (7)
- Europabild (7)
- Expedition Brochure (7)
- Expeditionsbericht (7)
- Exposure (7)
- Fachportal (7)
- Fantastische Literatur (7)
- Fassbinder, Rainer Werner (7)
- Feldforschung (7)
- Fernunterricht (7)
- Fichte, Johann Gottlieb (7)
- Filmkritik (7)
- Finance (7)
- Financial Regulation (7)
- Finanzierungsstruktur (7)
- Flaubert, Gustave (7)
- Foreign language teaching (7)
- Forensic entomology (7)
- Forschungsbericht (7)
- Frauenemanzipation (7)
- Frauenpolitik (SDAP) (7)
- Freidenker (7)
- Freie Liebe (7)
- Freizeit (7)
- GARCH (7)
- GIS (7)
- GPCR (7)
- Gegenwartsliteratur (7)
- Genauigkeit (7)
- Gene regulation (7)
- Genossenschaftliche Frauenbewegung (7)
- Genregulation (7)
- Genus verbi (7)
- German literature (7)
- Gerontologie (7)
- Geschichte 1933-1945 (7)
- Geschichtsunterricht (7)
- Geschlechterbeziehung (7)
- Gesundheitspolitik (7)
- Gewerbeaufsicht (7)
- Goethe-Universität Frankfurt (7)
- Gottsched, Johann Christoph (7)
- Griechenland (Altertum) (7)
- Guattari, Félix (7)
- HCC (7)
- Harz (7)
- Hemiptera (7)
- Hepatitis C (7)
- Herb induced liver injury (7)
- Herta Müller (7)
- Hilfsverb (7)
- Hitchcock (7)
- Hungary (7)
- Identification key (7)
- Identifikation (7)
- Identitätspolitik (7)
- Ikone (7)
- Immunohistochemistry (7)
- Immunological methods (7)
- Immunologische Methoden (7)
- Indústria cultural (7)
- International Financial Reporting Standards (7)
- Internationale Politik (7)
- Internationaler Vergleich (7)
- Jena (7)
- John (7)
- Johnson, Uwe (7)
- Kannibalismus <Motiv> (7)
- Kapitalgewinn (7)
- Kardiovaskuläre Krankheit (7)
- Karl Philipp (7)
- Karriere (7)
- Kaschnitz, Marie Luise (7)
- Kasperl (7)
- Katholische Arbeiterinnenbewegung (7)
- Kausalität (7)
- Kenya (7)
- Klopstock, Friedrich Gottlieb (7)
- Komposition <Wortbildung> (7)
- Konflikt (7)
- Konfliktlösung (7)
- Kreditwürdigkeit (7)
- Kriegsfürsorge (7)
- Kritische Ausgabe (7)
- Kulturerbe (7)
- Kunstpädagogik (7)
- Kybernetik (7)
- Latein (7)
- Laudatio (7)
- Lebensstil (7)
- Leibniz, Gottfried Wilhelm (7)
- Lesekompetenz (7)
- Liberdade (7)
- Linguistische Datenverarbeitung (7)
- Linkshegelianer (7)
- Lycosidae (7)
- MLL (7)
- Macaronesia (7)
- Macht <Motiv> (7)
- Makonde (7)
- Malaise trap (7)
- Manipulation (7)
- Mann (7)
- Marcuse (7)
- Martin (7)
- Martyrium (7)
- Mechanisms of disease (7)
- Medialität (7)
- Medienkompetenz (7)
- Mediensprache (7)
- Meinungsfreiheit (7)
- Metabolism (7)
- Metafiktion (7)
- Metallindustrie (7)
- Metonymie (7)
- Michel Foucault (7)
- Mitgliedsstaaten (7)
- Modalpartikel (7)
- Molecular neuroscience (7)
- Molekulardynamik (7)
- Monte-Carlo-Simulation (7)
- Moose (7)
- Moral Hazard (7)
- Morphonologie (7)
- Mygalomorphae (7)
- Märtyrer <Motiv> (7)
- Müller (7)
- Mündliche Kommunikation (7)
- NK cells (7)
- Nationenbildung (7)
- Naturphilosophie (7)
- Nebenläufigkeit (7)
- Neoliberalism (7)
- Nestroy, Johann (7)
- Neurology (7)
- Neuronales Netz (7)
- Neurons (7)
- Nietzsche (7)
- Normative Ordnungen (7)
- Normativität (7)
- Numerale (7)
- Nyanja (7)
- Nyanja-Sprache (7)
- Obesity (7)
- Odonata checklist (7)
- Orchidaceae (7)
- Organische Synthese (7)
- Osteoporosis (7)
- Othering (7)
- Oxidative stress (7)
- PD-L1 (7)
- Palästina (7)
- Pathogenesis (7)
- Performance (7)
- Pharmazie (7)
- Phase Diagrams (7)
- Philosoph (7)
- Pholcidae (7)
- Plato (7)
- Politics (7)
- Politikberatung (7)
- Politische Identität (7)
- Polytrauma (7)
- Popliteratur (7)
- Popmusik (7)
- Pregnancy (7)
- Preisbildung (7)
- Privacy (7)
- Privatisierung des Krieges (7)
- Programmiersprache (7)
- Proteins (7)
- Proteomanalyse (7)
- Präsenzlehre (7)
- Psycholinguistik (7)
- QCD phase diagram (7)
- Qualität (7)
- Quanten-Chromodynamik (7)
- Quantenchromodynamik (7)
- Quark (7)
- Quercus (7)
- Quercus robur (7)
- RFQ (7)
- Reaction time (7)
- Reactive oxygen species (7)
- Reduktion (7)
- Referenz <Linguistik> (7)
- Refugees (7)
- Rehabilitation (7)
- Rekonstruktion (7)
- Religionskritik (7)
- Responsibility to protect (7)
- Retirement (7)
- Rhinotragini (7)
- Risk assessment (7)
- Risk factors (7)
- Rolle (7)
- Romanistik (7)
- Rote-Liste-Arten (7)
- Rubus (7)
- Rumänisch (7)
- Russisch-Ukrainischer Krieg (7)
- Römische Geschichte (7)
- Schwangerschaftsabbruch (7)
- Seizure (7)
- Senegal (7)
- Sensory processing (7)
- Short story (7)
- Sichtbarkeit (7)
- Simmel, Georg (7)
- Slovakia (7)
- Snowden (7)
- Software (7)
- Sozialdemokratische Partei Deutschlands (SPD, 1890-) (7)
- Sparkasse (7)
- Species distribution modelling (7)
- Speech (7)
- Sprachgeschichte (7)
- Sprachproduktion (7)
- Stadtplanung (7)
- Stummfilm (7)
- Substantiv (7)
- Sudan (7)
- Systematik (7)
- Systemic risk (7)
- Säuglingssterblichkeit (7)
- Technologie (7)
- Tension (7)
- Terrorism (7)
- Textkohärenz (7)
- Theoriegeschichte (7)
- Therapie (7)
- Toxicity (7)
- Transfusion (7)
- Transitivität (7)
- Transkription (7)
- Traum <Motiv> (7)
- Tschechien (7)
- Ungeheuer (7)
- Unsterblichkeit (7)
- Unterhaltung (7)
- Vergütung (7)
- Verhalten (7)
- Vermittlung (7)
- Versammlungsfreiheit (7)
- Verschlusslaut (7)
- Vision (7)
- Visuelle Wahrnehmung (7)
- Volksaufklärung (7)
- Vulnerability (7)
- War (7)
- Werbesprache (7)
- Werbung (7)
- Willensfreiheit (7)
- Wolfram <von Eschenbach> (7)
- Wöchnerinnenschutz (7)
- X-Ray (7)
- X-Ray Structure Analysis (7)
- acute lymphoblastic leukemia (7)
- antiviral therapy (7)
- anxiety (7)
- aortic stenosis (7)
- aquatic insects (7)
- art (7)
- asthma (7)
- atrial fibrillation (7)
- beetles (7)
- biophysics (7)
- bipolar disorder (7)
- breeding (7)
- cGMP (7)
- capital structure (7)
- cell cycle (7)
- childhood (7)
- citizen science (7)
- cloud forest (7)
- cluster analysis (7)
- cochlear implant (7)
- colon cancer (7)
- concurrency (7)
- conduct disorder (7)
- cooperation (7)
- cytotoxicity (7)
- decision making (7)
- deep learning (7)
- deliberative democracy (7)
- density functional theory (7)
- descriptions (7)
- diet (7)
- diffusion tensor imaging (7)
- dung beetles (7)
- emancipation (7)
- expectations (7)
- fibrosis (7)
- financial system (7)
- forensic entomology (7)
- forward guidance (7)
- freshwater (7)
- functional magnetic resonance imaging (7)
- functional traits (7)
- genetics (7)
- global change (7)
- heart failure (7)
- hematopoietic stem cell transplantation (7)
- hermeneutics (7)
- human capital (7)
- immunology (7)
- indicator values (7)
- innovation (7)
- intertextuality (7)
- islamism (7)
- karst (7)
- leafhoppers (7)
- legal pluralism (7)
- leverage (7)
- liver cirrhosis (7)
- liverworts (7)
- longhorned beetles (7)
- machine-learning (7)
- mathematical modeling (7)
- mice (7)
- modeling (7)
- molecular phylogenetics (7)
- morphometrics (7)
- natural history (7)
- natural killer cells (7)
- neophytes (7)
- network analysis (7)
- new subspecies (7)
- nitric oxide (7)
- oligomerization (7)
- parasitoid wasps (7)
- particulate matter (7)
- perception (7)
- phylogeography (7)
- phytodiversity (7)
- polypharmacy (7)
- predictive coding (7)
- pregnancy (7)
- prognosis (7)
- prophylaxis (7)
- prudential supervision (7)
- qualitative research (7)
- quality control (7)
- racism (7)
- representation (7)
- resilience (7)
- rna (7)
- screening (7)
- seizure (7)
- shadow banking (7)
- signaling (7)
- sleep (7)
- social security (7)
- solitary bees (7)
- spectroscopy (7)
- stability (7)
- subjectivity (7)
- terminology (7)
- text book (7)
- thermal and non-thermal effects (7)
- thermische und nicht-thermische Effekte (7)
- trade (7)
- training (7)
- transcription (7)
- transcriptome (7)
- tumor-associated macrophages (7)
- vector (7)
- venture capital (7)
- visual cortex (7)
- whiteflies (7)
- wound exudation (7)
- zoogeography (7)
- Ökosystem (7)
- 3D printing (6)
- 401(k) plan (6)
- Abduktion <Logik> (6)
- Abnehmer (6)
- Achim von (6)
- Acinetobacter baumannii (6)
- Addition Compounds (6)
- Adenocarcinoma (6)
- Adhesion (6)
- Adverse Selection (6)
- Affect (6)
- Affix (6)
- Afrikanische Sprachen (6)
- Agitation (SDAP) (6)
- Agitation (SPS) (6)
- Akustik (6)
- Akzent (6)
- Alemannisch (6)
- Altern (6)
- Altertum (6)
- Altes Testament (6)
- Alzheimer (6)
- Amazon (6)
- Amerikabild (6)
- Analogie (6)
- Andreas (6)
- Anna Amalia <Sachsen-Weimar-Eisenach (6)
- Antike <Motiv> (6)
- Antiviral therapy (6)
- Anxiety (6)
- Apoptose (6)
- Arbeitsgedächtnis (6)
- Arbeitsloser (6)
- Arbeitswelt (6)
- Archaeology (6)
- Argentinien (6)
- Arnim (6)
- Atherosclerosis (6)
- Atlantic (6)
- Atlantic Ocean (6)
- Attitude (6)
- Auerbach, Berthold (6)
- Aufführung (6)
- Ausland (6)
- Ausländer, Rose (6)
- Autism (6)
- Autismus (6)
- BRD4 (6)
- Balloon enteroscopy (6)
- Balzac, Honoré de (6)
- Basel III (6)
- Bavaria (6)
- Belletristische Darstellung (6)
- Benin (6)
- Bericht (6)
- Berichterstattung (6)
- Beschaffungsmarketing (6)
- Bestimmungsbuch (6)
- Bevölkerungspolitik (6)
- Beziehungsmanagement (6)
- Biological control (6)
- Biophysik (6)
- Biozönose (6)
- Blindheit (6)
- Blindheit <Motiv> (6)
- Blockchain (6)
- Blog (6)
- Boden (6)
- Bodensee-Gebiet (6)
- Borstgrasrasen (6)
- Brasilienbild (6)
- Brentano (6)
- Buchmarkt (6)
- Böhmische Länder (6)
- Böll, Heinrich (6)
- C-reactive protein (6)
- CDK4/6 (6)
- COSMO-CLM (6)
- Calcium (6)
- Cameraria ohridella (6)
- Canada (6)
- Canary Islands (6)
- Canetti, Elias (6)
- Caretta caretta (6)
- Carl Schmitt (6)
- Carmen Sylva (6)
- Cassirer, Ernst (6)
- Caucasus (6)
- Cetacea (6)
- Chemistry (6)
- Christoph Martin (6)
- Citizenship (6)
- Climate (6)
- Clinical trial (6)
- Community ecology (6)
- Complications (6)
- Computational chemistry (6)
- Computational models (6)
- Conflict (6)
- Consensus (6)
- Consumers (6)
- Corporate governance (6)
- Cortex (6)
- Croatia (6)
- Croatian (6)
- Crohn’s disease (6)
- Crítica (6)
- Curriculum (6)
- Cyborg (6)
- Cytochromoxidase (6)
- D. A. (6)
- DMEK (6)
- Das Kunstwerk im Zeitalter seiner technischen Reproduzierbarkeit (6)
- Das Passagen-Werk (6)
- Death rates (6)
- Decision making (6)
- Deixis (6)
- Demokratisierung (6)
- Der Turm (6)
- Design (6)
- Deskriptivität (6)
- Deutsche <Motiv> (6)
- Deutscher Textilarbeiter-Verband (1906-) (6)
- Diabetes (6)
- Dialética negativa (6)
- Didactics (6)
- Differenz (6)
- Differenzierung (6)
- Digitale Lehre (6)
- Digitale Revolution (6)
- Digitalization (6)
- Distanz (6)
- Donald Trump (6)
- Dopamine (6)
- Dragonflies (6)
- Druckgrafik (6)
- Dung beetles (6)
- Dänemark (6)
- E2 enzyme (6)
- Elderly (6)
- Electronic Commerce (6)
- Elektronisches Publizieren (6)
- Elektrophysiologie (6)
- Emerging Market (6)
- Endothelium (6)
- Enteroscopy (6)
- Entrepreneurship (6)
- Entropie (6)
- Enzyme mechanisms (6)
- Ergativ (6)
- Erzähler (6)
- Erzähltextanalyse (6)
- Eschatologie (6)
- Ethnische Identität (6)
- Ethnobotanik (6)
- Europa <Motiv> (6)
- Europäische Währungsunion (6)
- Exotismus (6)
- Extracellular matrix (6)
- FT-IR-Spektroskopie (6)
- Fabaceae (6)
- Fabrikarbeit (6)
- Fair value accounting (6)
- Familienroman (6)
- Feldlinguistik (6)
- Feuilleton (6)
- Fichte, Hubert (6)
- Filmtechnik (6)
- Financial Crises (6)
- Financial literacy (6)
- Finanzierungstheorie (6)
- Flirt (6)
- Forschungsreise (6)
- Forster, Georg (6)
- Frage (6)
- Fragmentation (6)
- Frankfurt <Main, 2003> (6)
- Frankfurter Schule (6)
- Fränkisches Reich (6)
- Fulgoromorpha (6)
- Functional connectivity (6)
- Fungi (6)
- Funktion (6)
- Funktionale Kategorie (6)
- Fusion (6)
- Fühmann, Franz (6)
- Garten <Motiv> (6)
- Gedenken (6)
- Gerechtigkeit <Motiv> (6)
- Germanistische Linguistik (6)
- Geschichtsdarstellung (6)
- Geschlechterrolle <Motiv> (6)
- Gesellschaftsrecht (6)
- Gesetz (6)
- Gesundheitserziehung (6)
- Ghana (6)
- Glioblastoma (6)
- Glioma (6)
- Goethe, Johann Wolfgang von / Die Leiden des jungen Werthers (6)
- Goethe-Universität (6)
- Goethe-Universität Frankfurt am Main. Fachbereich Humanmedizin (6)
- Grimmelshausen, Hans Jakob Christoffel von (6)
- Grünbein, Durs (6)
- HADES (6)
- Handelsvolumen (6)
- Hausarbeitsgesetz (6)
- Hausgehilfin (6)
- Haushaltsführung (6)
- Health economics (6)
- Heavy Ion Collisions (6)
- Hebel, Johann Peter (6)
- Hedging (6)
- Heidegger (6)
- Heine (6)
- Hermann (6)
- Herzogin> (6)
- Heterotopie (6)
- Histology (6)
- Historische Semantik (6)
- Hochschullehre (6)
- Hodgkin lymphoma (6)
- Hoffmann von Fallersleben, August Heinrich (6)
- Hoffmann, Ernst T. A. (6)
- Hoftheater (6)
- Hong Kong (6)
- Horkheimer (6)
- Hydroptilidae (6)
- Höflichkeit (6)
- Hören (6)
- Hörrinde (6)
- ISA (6)
- Iberian Peninsula (6)
- Ich (6)
- Idealismus (6)
- Identification (6)
- Ikonographie (6)
- Ikonologie (6)
- Illokutiver Akt (6)
- Illustration (6)
- Image (6)
- Imagology (6)
- Immobilienfonds (6)
- Imperialismus (6)
- Indonesien (6)
- Indústria Cultural (6)
- Inequality (6)
- Infection (6)
- Informatik (6)
- Informationstechnologie (6)
- Interaction (6)
- Interbankenabkommen (6)
- Interest Rates (6)
- International Accounting Standards (6)
- Internationale Arbeiterhilfe (IAH, 1921-) (6)
- Internationale Rote Hilfe (IRH, 1922-) (6)
- Internationaler Frauentag (6)
- Internationaler Kreditmarkt (6)
- Internationalisierung (6)
- Intersubjectivity (6)
- Ionenkanal (6)
- Isländisch (6)
- Jandl, Ernst (6)
- Jugendfürsorge (6)
- Kaiserreich (6)
- Kaiserzeit (6)
- Kapitalstruktur (6)
- Kassner, Rudolf (6)
- Katholische Kirche (6)
- Keller, Gottfried (6)
- Kinases (6)
- Kollision (6)
- Kommunistische Partei Deutschlands (KPD, 1918-) (6)
- Kompetenz (6)
- Konjunktur (6)
- Konsumverein (6)
- Kontingenz (6)
- Kontrastive Phonologie (6)
- Kraus, Karl (6)
- Kreatives Schreiben (6)
- Kriminalgeschichte (6)
- Kuba (6)
- Kunstmärchen (6)
- Kunstwerk (6)
- Kurden (6)
- Kurdistan (6)
- König Ottokars Glück und Ende (6)
- Lamiinae (6)
- Langzeitarchivierung (6)
- Lattice QCD (6)
- Lautmalerei (6)
- Leaking (6)
- Legs (6)
- Lehnübersetzung (6)
- Leistungsbilanz (6)
- Lessing (6)
- Lexem (6)
- Lexicalized Tree Adjoining Grammar (6)
- Libyen (6)
- Liebeslyrik (6)
- Lieferung (6)
- Ligand <Biochemie> (6)
- Lindgren funnel (6)
- Litauisch (6)
- Literarischer Stil (6)
- Literatura austríaca (6)
- Liturgie (6)
- Liver transplantation (6)
- Lokativ (6)
- London (6)
- MEMOs (6)
- MRT (6)
- MSC (6)
- Machtstruktur (6)
- Malagassi-Sprache (6)
- Manga (6)
- Manuskript (6)
- Marxismus (6)
- Maske (6)
- Massenkultur (6)
- Massenspektrometrie (6)
- Mauritius (6)
- Mauthner, Fritz (6)
- Max Weber (6)
- Medical education (6)
- Medienphilosophie (6)
- Medium (6)
- Medizin und Gesundheit (6)
- Medizinstudium (6)
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- Methodenbericht (6)
- Millipedes (6)
- Model Uncertainty (6)
- Modus (6)
- Molekularbiologie (6)
- Moníková, Libuše (6)
- Morbidity (6)
- Morphogenesis (6)
- Mother tongue (6)
- Multivariate analysis (6)
- Mystik <Motiv> (6)
- Mündliche Literatur (6)
- Mündliche Überlieferung (6)
- NLP (6)
- NMR-Tomographie (6)
- NS-Zeit (6)
- Nachahmung (6)
- Nachhaltige Entwicklung (6)
- Natural Language Processing (6)
- Nature (6)
- Netzwerk (6)
- Neurolinguistik (6)
- New World (6)
- Niederdeutsch (6)
- Nitric oxide (6)
- Non-coding RNA (6)
- Non-small cell lung cancer (6)
- Normative reconstruction (6)
- Novemberrevolution (6)
- Numerical accuracy (6)
- Nutzungsintensivierung (6)
- OSCE (6)
- OTC markets (6)
- Oaxaca (6)
- Objekt (6)
- Online-Publizieren (6)
- Opposition (6)
- Oral anticoagulation (6)
- Ost-West-Konflikt (6)
- Outcomes (6)
- PD1/PDL1 (6)
- PELDOR (6)
- PI3K (6)
- PTSD (6)
- Pakistan (6)
- Palatalisierung (6)
- Parabel <Literatur> (6)
- Paracelsus (6)
- Paramilitärs (6)
- Parkinson's disease (6)
- Partizip (6)
- Parzival (6)
- Pathos (6)
- Pathosformel (6)
- Patient blood management (6)
- Pennebaker (6)
- Perfekt (6)
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- Personalpronomen (6)
- Personennamenkunde (6)
- Philosophische Anthropologie (6)
- Photosynthese (6)
- Phraseodidaktik (6)
- Physical activity (6)
- Picea abies (6)
- Pierre Bourdieu (6)
- Plasma (6)
- Pneumonia (6)
- Poe, Edgar Allan (6)
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- Descartes, René (4)
- Desmiphorini (4)
- Deutsche Bundesbank (4)
- Deutsche Zentrumspartei (Z, 1870-) (4)
- Deutscher Bund für Mutterschutz (DBM, 1905-) (4)
- Diagnostic medicine (4)
- Didaktik der Lektüreauswahl (4)
- Die Judenbuche (4)
- Die Schlafwandler (4)
- Dienstboten (4)
- Diffusion (4)
- Digital Finance (4)
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- Digitale Daten (4)
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- Dilettantismus (4)
- Diorama (4)
- Dirac (4)
- Disability (4)
- Discretion (4)
- Diskurstheorie (4)
- Displacement (4)
- Disposition Effect (4)
- Dispositiv (4)
- Disziplin <Wissenschaft> (4)
- Divina commedia (4)
- Docking (4)
- Doderer, Heimito von (4)
- Doku Mittelstufe (4)
- Doku Oberstufe (4)
- Dokumentarliteratur (4)
- Drell-Yan (4)
- Drogen (4)
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- Drug discovery (4)
- Duineser Elegien (4)
- Dylan (4)
- Dynamical systems (4)
- Dynamisches Gleichgewicht (4)
- Dyserinck, Hugo (4)
- Dyson–Schwinger equations (4)
- Döblin, Alfred / Berlin Alexanderplatz (4)
- Düffel, John von (4)
- E. coli (4)
- EPR (4)
- ER stress (4)
- Early Carboniferous (4)
- Eastern Arc Mountains (4)
- Ebola (4)
- Eginald Schlattner (4)
- Ehe <Motiv> (4)
- Ehe- und Familienrecht (4)
- Ehrung (4)
- Eich, Günter (4)
- Eichendorff, Joseph von (4)
- Eigenkapital (4)
- Einbahnstraße (4)
- Einfluss (4)
- Einheit (4)
- Einkommensteuer (4)
- Einsamkeit <Motiv> (4)
- Electroencephalography – EEG (4)
- Electron microscopy (4)
- Elektra (4)
- Elektronenspinresonanz (4)
- Elektronentransfer (4)
- Embryos (4)
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- Erasmus, Desiderius (4)
- Ergänzung <Linguistik> (4)
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- Estudios organizacionales (4)
- Ethiopia (4)
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- Exotic options (4)
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- Expectations (4)
- Expedition (4)
- Experimentelle Lyrik (4)
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- Eyes (4)
- FEBID (4)
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- Figur (4)
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- Fisher information (4)
- Floristisch-Soziologische Arbeitsgemeinschaft (4)
- Flow (4)
- Flugschrift (4)
- Flusser, Vilém (4)
- Flusssediment (4)
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- Formale Sprache (4)
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- Frankfurt <Main> / Institut für Kernphysik (4)
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- Frankfurt school (4)
- Frankliniella occidentalis (4)
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- Freud, Sigmund: Zeitgemäßes über Krieg und Tod (4)
- Freundschaft <Motiv> (4)
- Friede <Motiv> (4)
- Friedensbewegung (4)
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- Functional magnetic resonance imaging (4)
- Funktionalismus <Linguistik> (4)
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- GABA (4)
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- Gewerkschaftsbund der Angestellten (GdA, 1920-) (4)
- Gewinn (4)
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- Glucose (4)
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- Goethe (4)
- Goethe, Johann Wolfgang von / Die Wahlverwandtschaften (4)
- Google (4)
- Gott (4)
- Gottfried August (4)
- Gotthelf, Jeremias (4)
- Gotthold Ephraim (4)
- Graphic Novel (4)
- Greater Antilles (4)
- Greek (4)
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- Grillparzer, Franz / König Ottokars Glück und Ende (4)
- Gross-Neveu model (4)
- Grundrecht (4)
- Grundrechte (4)
- Gruša, Jiří (4)
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- HIF (4)
- HPLC (4)
- Hadloub, Johannes (4)
- Haftung (4)
- Hamann, Johann Georg (4)
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- Herzl, Theodor (4)
- Herzogin Anna Amalia Bibliothek (4)
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- Heterogeneity (4)
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- Hobbes, Thomas (4)
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- Houellebecq, Michel (4)
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- Huber, Therese (4)
- Huch, Ricarda (4)
- Hugo, Victor (4)
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- Humanität <Motiv> (4)
- Humboldt, Alexander von (4)
- Hunsrückisch (4)
- Husserl, Edmund (4)
- Hybridisierung (4)
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- IAP proteins (4)
- ICC (4)
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- Klee, Paul (4)
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- Pamuk, Orhan (4)
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- Paul, Jean (4)
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- Queensland (4)
- RCT (4)
- RDF (4)
- REM sleep (4)
- RFQ-Beschleuniger (4)
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- Schelling, Friedrich Wilhelm Joseph von (4)
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- Schwarzenbach, Annemarie (4)
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- Schönberg, Arnold (4)
- Science-Fiction-Literatur (4)
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- Self-fulfilling Prophecy (4)
- Seltene Erkrankungen (4)
- Semantic Web (4)
- Semiformação (4)
- Senescence (4)
- Sex (4)
- Sex differences (4)
- Sexualaufklärung (4)
- Sibiu (4)
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- Signaltransduktion (4)
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- Small molecules (4)
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- Structural biology (4)
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- Suttner, Bertha von: Das Maschinenzeitalter (4)
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- Taxa (4)
- Teaching (4)
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- Teoría Crítica (4)
- Text2Scene (4)
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- The Sacrifice of Abraham (4)
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- Therapy (4)
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- Toller, Ernst (4)
- Tolstoj, Lev Nikolaevič (4)
- Tools and resources (4)
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- Varnhagen, Rahel (4)
- Vater (4)
- Venture capital (4)
- Verband Süddeutscher Katholischer Arbeiterinnenvereine (1906-) (4)
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- Vertreibung <Motiv> (4)
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- Weimarer Beiträge (Zeitschrift) (4)
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- Women (4)
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- Zentralverband der Hausangestellten Deutschlands (1909-) (4)
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- ribosome (4)
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- 18S rRNA gene (3)
- 20. Jahrhundert (3)
- 28S (3)
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- 5′-UTR (3)
- ADC (3)
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- ALL (3)
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Background and Objectives: Proteins of the coagulation system contribute to autoimmune inflammation in patients with multiple sclerosis (MS). On blood-brain barrier (BBB) disruption, fibrinogen enters the CNS and is rapidly converted to fibrin, unfolding pleiotropic autoimmune mechanisms. Fibrin accumulation leads to subsequent proteolytic degradation that results in D-dimer generation. The primary objective of this study was to determine intrathecal levels of D-dimer in CSF as a measure of intrathecal coagulation cascade activation and to evaluate its diagnostic utility in patients with MS in contrast to healthy subjects. Key secondary objectives included analysis of CSF D-dimer in differential diagnoses of MS and its relation to routine clinical markers of disease activity.
Methods: Patients admitted for the assessment of suspected MS were prospectively recruited from October 2017 to December 2020. Blood plasma and citrated CSF samples were analyzed using a highly sensitive luminescent oxygen channeling immunoassay. Intrathecal generation of D-dimer was analyzed by adjusting for CSF/serum albumin (Qalb) and CSF/plasma D-dimer quotients (QD-dimer), and corresponding CSF fibrinogen levels were determined. Final diagnoses after full evaluation and clinical data were recorded.
Results: Of 187 patients, 113 patients received a diagnosis of MS or clinically/radiologically isolated syndrome. We found increased intrathecal CSF D-dimer generation levels (QD-dimer/Qalb-index) for patients with relapsing-remitting MS (RRMS; n = 71, median 4.7, interquartile range [IQR] 2.5–8.0) when compared with those for disease controls (n = 22, median 2.6, IQR 2.1–4.8, p = 0.031). Absolute CSF D-dimer values correlated with CSF fibrinogen levels (r = 0.463; p < 0 .001) and CSF leukocytes (r = 0.273; p = 0.003) and were elevated in MS patients with contrast enhancement (CE) compared with MS patients without CE on MRI (n = 48, median 6 ng/mL, and IQR 3–15.25 vs n = 41, median 4 ng/mL, and IQR 2–7; p = 0.026). Exploratory subgroup analyses indicated a correlation of intrathecal inflammatory activity and CSF D-dimer levels.
Discussion: D-dimer in CSF can be reliably determined and correlates with markers of CNS inflammation and CSF fibrinogen levels. Adjusted for BBB dysfunction, CSF D-dimer may allow the identification of intrathecal coagulation cascade activation in patients with MS.
Classification of Evidence: This study provides Class I evidence that CSF D-dimer levels are elevated in patients with RRMS.
Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells
(2022)
So far, the human health impacts of nano- and microplastics are poorly understood. Thus, we investigated whether nanoplastics exposure induces inflammatory processes in primary human monocytes and monocyte-derived dendritic cells. We exposed these cells in vitro to nanoplastics of different shapes (irregular vs. spherical), sizes (50–310 nm and polydisperse mixtures) and polymer types (polystyrene; polymethyl methacrylate; polyvinyl chloride, PVC) using concentrations of 30–300 particles cell−1. Our results show that irregular PVC particles induce the strongest cytokine release of these nanoplastics. Irregular polystyrene triggered a significantly higher pro-inflammatory response compared to spherical nanoplastics. The contribution of chemicals leaching from the particles was minor. The effects were concentration-dependent but varied markedly between cell donors. We conclude that nanoplastics exposure can provoke human immune cells to secrete cytokines as key initiators of inflammation. This response is specific to certain polymers (PVC) and particle shapes (fragments). Accordingly, nanoplastics cannot be considered one homogenous entity when assessing their health implications and the use of spherical polystyrene nanoplastics may underestimate their inflammatory effects.
There has been a renewed interest in the potential use of psychedelics for the treatment of psychiatric conditions. Nevertheless, little is known about the mechanism of action and molecular pathways influenced by ayahuasca use in humans. Therefore, for the first time, our study aims to investigate the human metabolomics signature after consumption of a psychedelic, ayahuasca, and its connection with both the psychedelic-induced subjective effects and the plasma concentrations of ayahuasca alkaloids.
Plasma samples of 23 individuals were collected both before and after ayahuasca consumption. Samples were analysed through targeted metabolomics and further integrated with subjective ratings of the ayahuasca experience (i.e., using the 5-Dimension Altered States of Consciousness Rating Scale [ASC]), and plasma ayahuasca-alkaloids using integrated network analysis. Metabolic pathways enrichment analysis using diffusion algorithms for specific KEGG modules was performed on the metabolic output.
Compared to baseline, the consumption of ayahuasca increased N-acyl-ethanolamine endocannabinoids, decreased 2-acyl-glycerol endocannabinoids, and altered several large-neutral amino acids (LNAAs). Integrated network results indicated that most of the LNAAs were inversely associated with 9 out of the 11 subscales of the ASC, except for tryptophan which was positively associated. Several endocannabinoids and hexosylceramides were directly associated with the ayahuasca alkaloids. Enrichment analysis confirmed dysregulation in several pathways involved in neurotransmission such as serotonin and dopamine synthesis.
In conclusion, a crosstalk between the circulating LNAAs and the subjective effects is suggested, which is independent of the alkaloid concentrations and provides insights into the specific metabolic fingerprint and mechanism of action underlying ayahuasca experiences.
Pathologies associated with tissue ischemia/reperfusion (I/R) in highly metabolizing organs such as the brain and heart are leading causes of death and disability in humans. Molecular mechanisms underlying mitochondrial dysfunction during acute injury in I/R are tissue-specific, but their details are not completely understood. A metabolic shift and accumulation of substrates of reverse electron transfer (RET) such as succinate are observed in tissue ischemia, making mitochondrial complex I of the respiratory chain (NADH:ubiquinone oxidoreductase) the most vulnerable enzyme to the following reperfusion. It has been shown that brain complex I is predisposed to losing its flavin mononucleotide (FMN) cofactor when maintained in the reduced state in conditions of RET both in vitro and in vivo. Here we investigated the process of redox-dependent dissociation of FMN from mitochondrial complex I in brain and heart mitochondria. In contrast to the brain enzyme, cardiac complex I does not lose FMN when reduced in RET conditions. We proposed that the different kinetics of FMN loss during RET is due to the presence of brain-specific long 50 kDa isoform of the NDUFV3 subunit of complex I, which is absent in the heart where only the canonical 10 kDa short isoform is found. Our simulation studies suggest that the long NDUFV3 isoform can reach toward the FMN binding pocket and affect the nucleotide affinity to the apoenzyme. For the first time, we demonstrated a potential functional role of tissue-specific isoforms of complex I, providing the distinct molecular mechanism of I/R-induced mitochondrial impairment in cardiac and cerebral tissues. By combining functional studies of intact complex I and molecular structure simulations, we defined the critical difference between the brain and heart enzyme and suggested insights into the redox-dependent inactivation mechanisms of complex I during I/R injury in both tissues.
"High-aluminous coal" is an important coal kind and widely distributed in North China in age of Permo-Carboniferous period. To explore their occurrence state, a total of 15 harmful elements (Li, Ga, In, Cd, Cr, Pb, Be, Mn, Zn, Ag, Co, Ni, Cu, Ba and U) in the No.9 coal and No.11 coal collected from Pingshuo mining district were determined by inductively coupled plasma mass spectrometry (ICP-MS) and scanning electron microscope with energy spectrum (SEM-EDX). The results showed that the content of Li, Ga, In, Pb, Ag and U were all exceed the world hard coal. In view of the result of clustering analysis within trace elements, it was found that Co, Ni, Zn, Cu, Ag and Cr were mainly associated with sulfide minerals due to their common sulfophilic property. Manganese was mainly occurred in carbonate minerals, while Ba, Cd and U were mainly associated with total minerals. In addition, Pb was related to sulfides and Be is mainly distributed in clay minerals. The enrichment of such harmful elements in Pingshuo coal was caused by the combined effect of transgression and input of terrestrial materials in the peat accumulation stage. Li, Ga, In and Ag have reached the harmful grade.
Objectives: To investigate whether citizens’ adherence to health-protective non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic is predicted by identity leadership, wherein leaders are perceived to create a sense of shared national identity.
Design: Observational two-wave study. Hypotheses testing was conducted with structural equation modelling.
Setting: Data collection during the COVID-19 pandemic in China, Germany, Israel and the USA in April/May 2020 and four weeks later.
Participants: Adults in China (n=548, 66.6% women), Germany (n=182, 78% women), Israel (n=198, 51.0% women) and the USA (n=108, 58.3% women).
Measures: Identity leadership (assessed by the four-item Identity Leadership Inventory Short-Form) at Time 1, perceived shared national identification (PSNI; assessed with four items) and adherence to health-protective NPIs (assessed with 10 items that describe different health-protective interventions; for example, wearing face masks) at Time 2.
Results: Identity leadership was positively associated with PSNI (95% CI0.11 to 0.30, p<0.001) in all countries. This, in turn, was related to more adherence to health-protective NPIs in all countries (95% CI 0.03 to 0.36, 0.001≤p≤0.017) except Israel (95% CI−0.03 to 0.27, p=0.119). In Germany, the more people saw Chancellor Merkel as engaging in identity leadership, the more they adhered to health-protective NPIs (95% CI 0.04 to 0.18, p=0.002). In the USA, in contrast, the more people perceived President Trump as engaging in identity leadership, the less they adhered to health-protective NPIs (95% CI−0.17 to −0.04, p=0.002).
Conclusions: National leaders can make a difference by promoting a sense of shared identity among their citizens because people are more inclined to follow health-protective NPIs to the extent that they feel part of a united ‘us’. However, the content of identity leadership (perceptions of what it means to be a nation’s citizen) is essential, because this can also encourage people to disregard such recommendations.
Patients with coronavirus disease 19 (COVID-19) commonly show abnormalities of liver tests (LTs) of undetermined cause. Considering drugs as tentative culprits, the current systematic review searched for published COVID-19 cases with suspected drug-induced liver injury (DILI) and established diagnosis using the diagnostic algorithm of RUCAM (Roussel Uclaf Causality Assessment Method). Data worldwide on DILI cases assessed by RUCAM in COVID-19 patients were sparse. A total of 6/200 reports with initially suspected 996 DILI cases in COVID-19 patients and using all RUCAM-based DILI cases allowed for a clear description of clinical features of RUCAM-based DILI cases among COVID-19 patients: (1) The updated RUCAM published in 2016 was equally often used as the original RUCAM of 1993, with both identifying DILI and other liver diseases as confounders; (2) RUCAM also worked well in patients treated with up to 18 drugs and provided for most DILI cases a probable or highly probable causality level for drugs; (3) DILI was preferentially caused by antiviral drugs given empirically due to their known therapeutic efficacy in other virus infections; (4) hepatocellular injury was more often reported than cholestatic or mixed injury; (5) maximum LT values were found for alanine aminotransferase (ALT) 1.541 U/L and aspartate aminotransferase (AST) 1.076 U/L; (6) the ALT/AST ratio was variable and ranged from 0.4 to 1.4; (7) the mean or median age of the COVID-19 patients with DILI ranged from 54.3 to 56 years; (8) the ratio of males to females was 1.8–3.4:1; (9) outcome was favorable for most patients, likely due to careful selection of the drugs and quick cessation of drug treatment with emerging DILI, but it was fatal in 19 patients; (10) countries reporting RUCAM-based DILI cases in COVID-19 patients included China, India, Japan, Montenegro, and Spain; (11) robust estimation of the percentage contribution of RUCAM-based DILI for the increased LTs in COVID-19 patients is outside of the current scope. In conclusion, RUCAM-based DILI with its clinical characteristics in COVID-19 patients and its classification as a confounding variable is now well defined, requiring a new correct description of COVID-19 features by removing DILI characteristics as confounders.
Environmental gradients have emerged as important barriers to structuring populations and species distributions. We set out to test whether the strong salinity gradient from the marine North Sea to the brackish Baltic Sea in northern Europe represents an ecological and genetic break, and to identify life history traits that correlate with the strength of this break. We accumulated mitochondrial cytochrome oxidase subunit 1 sequence data, and data on the distribution, salinity tolerance, and life history for 28 species belonging to the Cnidaria, Crustacea, Echinodermata, Mollusca, Polychaeta, and Gastrotricha. We included seven non-native species covering a broad range of times since introduction, in order to gain insight into the pace of adaptation and differentiation. We calculated measures of genetic diversity and differentiation across the environmental gradient, coalescent times, and migration rates between North and Baltic Sea populations, and analyzed correlations between genetic and life history data. The majority of investigated species is either genetically differentiated and/or adapted to the lower salinity conditions of the Baltic Sea. Species exhibiting population structure have a range of patterns of genetic diversity in comparison with the North Sea, from lower in the Baltic Sea to higher in the Baltic Sea, or equally diverse in North and Baltic Sea. Two of the non-native species showed signs of genetic differentiation, their times since introduction to the Baltic Sea being about 80 and >700 years, respectively. Our results indicate that the transition from North Sea to Baltic Sea represents a genetic and ecological break: The diversity of genetic patterns points toward independent trajectories in the Baltic compared with the North Sea, and ecological differences with regard to salinity tolerance are common. The North Sea–Baltic Sea region provides a unique setting to study evolutionary adaptation during colonization processes at different stages by jointly considering native and non-native species.
Tight control over transcription factor activity is necessary for a sensible balance between cellular proliferation and differentiation in the embryo and during tissue homeostasis by adult stem cells, but mechanistic details have remained incomplete. The homeodomain transcription factor MEIS2 is an important regulator of neurogenesis in the ventricular–subventricular zone (V-SVZ) adult stem cell niche in mice. We here identify MEIS2 as direct target of the intracellular protease calpain-2 (composed of the catalytic subunit CAPN2 and the regulatory subunit CAPNS1). Phosphorylation at conserved serine and/or threonine residues, or dimerization with PBX1, reduced the sensitivity of MEIS2 towards cleavage by calpain-2. In the adult V-SVZ, calpain-2 activity is high in stem and progenitor cells, but rapidly declines during neuronal differentiation, which is accompanied by increased stability of MEIS2 full-length protein. In accordance with this, blocking calpain-2 activity in stem and progenitor cells, or overexpression of a cleavage-insensitive form of MEIS2, increased the production of neurons, whereas overexpression of a catalytically active CAPN2 reduced it. Collectively, our results support a key role for calpain-2 in controlling the output of adult V-SVZ neural stem and progenitor cells through cleavage of the neuronal fate determinant MEIS2.
Die vorliegende Arbeit beschreibt die Entwicklung eines interaktionalen Simulationsmodells zum späteren Einsatz in der VR-Simulation Clasivir 2.0 (Classroom Simulator in Virtual Reality), welche in der Lehrkräftebildung eingesetzt werden soll. Das Clasivir-Simulationsmodell wurde im Rahmen eines Prototyps implementiert und zwei anderen Simulationsmodellen in einem Fragebogen entgegengestellt. Ein Simulationsmodell beschreibt im Kontext einer digitalen Schulunterrichtssimulation, wie sich SuS in der Simulation verhalten.
Die drei Simulationsmodelle wurden über zwei unterschiedliche Typen von Video-Visualisierungen, genannt Mockup-Videos, dargestellt: Zum einen über eine 2D-Darstellung aus Vogelperspektive, zum anderen über eine 3D-Darstellung, in welcher 3D-Modelle von SuS animiert wurden. Bei dem realen Simulationsmodell handelt es sich um eine Übertragung einer authentischen Videoaufzeichnung von Unterricht einer hessischen Realschule in 2D/3D-Visualisierungen. Im randomisierten Simulationsmodell führen SuS ihre Verhalten zufällig aus. Alle Modelle basieren auf zweisekündigen Intervallen. Im Falle des realen Simulationsmodells wurde dies durch Analyse aller beobachtbaren einundzwanzig SuS gewonnen, im Falle des Clasivir-Simulationsmodells wurden die Vorhersagen des Simulationsmodells übertragen. Das Simulationsmodell von Clasivir basiert auf behavior trees, stellt eine Art von künstlicher Intelligenz dar und modelliert das SuS-Verhalten größtenteils in Abhängigkeit von Lehrkrafthandlungen. Die Entwicklung des interaktionalen Simulationsmodells von Clasivir ist eine Kernkomponente dieser Arbeit. Das Simulationsmodell basiert auf empirischen Ergebnissen aus den Bereichen der Psychometrie, der pädagogischen Psychologie, der Pädagogik und Ergebnissen der Simulations-/KI-Forschung. Ziel war die Entwicklung eines Modells, das nicht nur auf normativen Vorhersagen basiert, sondern empirisch und theoretisch valide ist. Nur wenige Simulationsmodelle in Unterrichtssimulationen werden mit dieser Art von Transparenz beschrieben, was eines der Alleinstellungsmerkmale dieser Arbeit ist. Es wurden Anstrengungen unternommen die vorliegenden empirischen Ergebnisse in einen kausalen Zusammenhang zu bringen, der mathematisch modelliert wurde. Im Zentrum steht die Konzentration von SuS, welche Ein uss auf Stör-, Melde- und Antwortverhalten hat. Diese Variable wird durch andere situative und personenbezogene Variablen (im Sinne von traits) ergänzt. Wo keine direkten empirischen Ergebnisse vorlagen wurde versucht plausibles Verhalten anhand der Übertragung von Konzeptionsmodellen zu gewinnen.
Da die bisherige Verwendung der angrenzenden Begriffe rund um die Simulationsentwicklung bislang sehr inkonsistent war, wurde es notwendig diese Termini zu definieren. Hervorzuheben ist die Entwicklung einer Taxonomie digitaler Unterrichtssimulationen, die so bislang nicht existierte. Anhand dieser Taxonomie und der erarbeiteten Fachtermini wurden Simulationen in der Lehrkräftebildung auf ihre Modellierung des Simulationsmodells hin untersucht. Die Untersuchung der Simulationen simSchool und VCS war, da sie einen verwandten Ansatz zu Clasvir verfolgen, besonders ergiebig.
Nach der Generierung der Mockup-Videos wurden N=105 Studierende, N=102 davon Lehramtsstudierende, aufgefordert, in einem Online-Fragebogen zwei der Simulationsmodelle miteinander zu vergleichen. Lehramtsstudierende wurden ausgewählt, da sie die Zielgruppe der Simulation sind. Welche Modelle die Partizipantinnen verglichen, war abhängig von der Gruppe der sie zugeteilt wurden. Hierbei wurde neben den Simulationsmodellen auch die visuelle Darstellung variiert. Insbesondere wurden die Partizipantinnen darum gebeten, den Fidelitätsgrad des Simulationsmodells, also den Maßstab, wie realistisch die Partizipantinnen das Verhalten der SuS in der Simulation fanden, zu bewerten. Inferenzstatistisch bestätigte sich, dass Partizipantinnen keinen Unterschied zwischen dem realen Simulationsmodell und dem Clasivir-Simulationsmodell erkennen konnten (t=1.463, df=178.9, p=.1452), aber das randomisierte Simulationsmodell mit einer moderaten Effektstärke von d=.634 als signifikant schlechter einschätzten (t=-2.5231, df=33.581, p=.008271). Die Art der Darbietung (2D oder 3D) hatte keinen statistisch signifikanten Einfluss auf die wahrgenommene Schwierigkeit der Bewertung (z=1.2426, p=.107). Damit kann festgestellt werden, dass eine komplexe und zeitintensive 3D-Visualisierung eines Simulationsmodells bei noch nicht vorliegender Simulation nicht erforderlich ist. Das Clasivir-Simulationsmodell wird als realistisch wahrgenommen. Es kann damit empfohlen werden, es in der VR-Simulation zu verwenden.
Im Ausblick werden bereits während des Schreibens der Arbeit gemachte Entwicklungen beschrieben und Konzepte zum weiteren Einsatz der Ergebnisse entwickelt. Es wird darauf verwiesen, dass eine erste Version eines VR-Simulators entwickelt wurde (Clasivir 1.0), der jedoch rein deterministisch funktioniert und noch nicht das in dieser Arbeit entwickelte Simulationsmodell inkludiert.
Anthropogenic activities have a major impact on our planet and rapidly drive biodiversity loss in ecosystems at a global scale. Particularly over the last century, rising CO2 emissions significantly raised global temperatures and increased the intensity and frequency of droughts and heatwaves. Additionally, agricultural land use and fossil fuel combustion contribute to the continuous release of nitrogen (N) and phosphorus (P) into ecosystems worldwide through extensive fertilization and deposition from the atmosphere. It is important to understand how these rapid changes affect the evolution of plant populations and their adaptive potential. Adaptation by natural selection (i.e., adaptive evolution) within a few generations is an essential process as a response to rapid environmental changes. Rapid evolution of plant populations can be detected by using the so-called resurrection approach. Here, diaspores (i.e., seeds) from a population are collected before (ancestors) and after (descendants) a potential selection pressure (e.g., consecutive years of drought or changes in nutrient supply). Comparing phenotypes of ancestors and descendants in a common environment such as an outside garden, greenhouse, or climate chamber, may then reveal evolutionary changes. Ideally, plants are first grown in a common environment for an intermediate refresher generation to reduce parental and storage effects.
The aim of this thesis was to investigate the occurrence of adaptive evolution in natural plant populations in response to rapidly changing environments over the past three decades. I conducted three experiments using the resurrection approach to generate comprehensive data on the adaptive processes that acted on three plant populations from three different species over the last three decades. Furthermore, I filled knowledge gaps in plant evolutionary ecology and conceptually developed the resurrection approach further.
In Chapter I, I performed a novel approach by testing for adaptive evolution in natural plant populations using the resurrection approach in combination with in-situ transplantations. I cultivated seedlings from ancestors (23 – 26 years old) and contemporary descendants of three perennial species (Melica ciliata, Leontodon hispidus and Clinopodium vulgare) from calcareous grasslands in the greenhouse and In Chapter III, I assessed the reproducibility of phenotypic differences between genotypes among three different growth facilities (climate chamber, greenhouse, and outdoor garden). I also evaluated differences in phenotypic expression between plants grown after one vs. two intermediate generations (i.e., refresher generations). I performed this experiment within the framework of the resurrection approach and compared ancestors and descendants of the same population of Leontodon hispidus.
I observed very strong differences among plants growing in the different growth facilities. I found a significant interaction between the growth facility and the temporal origin (ancestors vs. descendants): descendants had significantly larger rosettes than ancestors only in the greenhouse and they flowered significantly later than ancestors exclusively in the climate chamber. I did not find significant differences between intermediate generations within the growth facilities. Overall, Chapter III shows that the use of a particular experimental system can dictate the presence and magnitude of phenotypic differences. This implies that absence of evidence is not evidence of absence when it comes to investigating genetically based trait differentiation among plant origins (in space or time). Experimental systems should be carefully designed to provide meaningful conditions, ideally mimicking the environmental conditions of the population’s origins. Finally, growing a second intermediate generation did not impact the genetic differences of ancestors and descendants within the environments, supporting the idea that only one intermediate generation may be sufficient to reduce detectable parental and storage effects.
The resurrection approach allows a better understanding of rapid plant adaptation, but some limitations deserve to be highlighted. I only studied one population per species, and Chapters II and III only focus on one population of L. hispidus, which is also hampering generalizations, as adaptive potential can vary greatly among populations of the same species. I only compared the ancestral genotypes to one descendant sample with a long time span in between (26 – 28 years), which makes it hard to pinpoint the selection agents that caused the genetic differentiation among the sampling years. Hence, closely monitoring biotic and abiotic factors of the studied populations between the ancestral and descendant sampling in future studies, would make identifying the responsible selection pressures more precise. I also recommend sampling multiple populations over consecutive years to improve the robustness of results and make generalizations more approachable.Furthermore, combining the resurrection approach with other methods such as in-situ transplantations will be valuable to offset the limitation that adaptations cannot be proven under artificial conditions (e.g., in the greenhouse).
Objective: Randomized trials have shown that concomitant methotrexate (MTX) augments the effectiveness of tumour necrosis factor (TNF) inhibitors in rheumatoid arthritis (RA), but its benefit in psoriatic arthritis (PsA) has not been demonstrated. The goal of this study was to examine whether the impact of concomitant MTX on therapeutic outcomes in patients with PsA was similar to its effects in RA.
Methods: We used data from highly comparable and concurrent observational studies of patients with PsA (N = 1424) or RA (N = 3148) who initiated adalimumab therapy during routine clinical care. The 28-joint Disease Activity Score (DAS28) and patient-reported pain scores were evaluated in patients who received 24 months of continuous treatment with adalimumab monotherapy or adalimumab + MTX and in patients who initiated or stopped concomitant MTX during ongoing adalimumab therapy.
Results: Twenty-four months of continuous treatment with adalimumab + MTX was superior to adalimumab monotherapy in RA patients, while no significant difference was observed in patients with PsA. RA patients who added MTX during the study showed significant individual improvements in DAS28 and pain scores at 6 months after the change in therapy, while those who removed MTX had slight increases in disease activity. In contrast, in patients with PsA, neither initiation nor removal of MTX during continuous adalimumab therapy had a significant effect on therapeutic outcomes.
Conclusion: Addition of MTX to adalimumab confers further therapeutic benefit in patients with RA, but not in those with PsA, suggesting differences in MTX effects in these two patient populations.
Clinicaltrials.gov NCT01078090, NCT01077258, NCT01111240
Aim: Replicate the analysis conducted by Prof. Dr. Alexander W. Schmidt-Catran (Goethe University Frankfurt), Prof. Dr. Malcolm Fairbrother (Umea University), and Prof. Dr. Hans-Jürgen Andreß (University of Cologne) that was published in a special issue on Cross-National Comparative Research in the German academic journal Kölner Zeitschrift für Soziologie und Sozialpsychologie in 2019. Result: Almost all calculations, tables and graphs from Schmidt-Catran et al. (2019) could be replicated sufficiently well in R.
Recombinant DNA technology is an essential area of life engineering. The main aim of research in this field is to experimentally explore the possibilities of repairing damaged human DNA, healing or enhancing future human bodies. Based on ethnographic research in a Czech biochemical laboratory, the article explores biotechnological corporealities and their specific ontology through dealings with bio-objects, the bodywork of scientists. Using the complementary concepts of utopia and heterotopia, the text addresses the situation of bodies and bio-objects in a laboratory. Embodied utopias are analyzed as material semiotic phenomena that are embodied by scientists in their visions and emotions and that are related to potential bodies and to future, not-yet-actualized embodiments. As a counterpart to this, the text explores embodied heterotopias, which are always the other spaces, like biotechnological bio-objects that are simulated in computers or stored in special solutions.
Hematopoietic mutations in epigenetic regulators like DNA methyltransferase 3 alpha (DNMT3A), play a pivotal role in driving clonal hematopoiesis of indeterminate potential (CHIP), and are associated with unfavorable outcomes in patients suffering from heart failure (HF). However, the precise interactions between CHIP-mutated cells and other cardiac cell types remain unknown. Here, we identify fibroblasts as potential partners in interactions with CHIP-mutated monocytes. We used combined transcriptomic data derived from peripheral blood mononuclear cells of HF patients, both with and without CHIP, and cardiac tissue. We demonstrate that inactivation of DNMT3A in macrophages intensifies interactions with cardiac fibroblasts and increases cardiac fibrosis. DNMT3A inactivation amplifies the release of heparin-binding epidermal growth factor-like growth factor, thereby facilitating activation of cardiac fibroblasts. These findings identify a potential pathway of DNMT3A CHIP-driver mutations to the initiation and progression of HF and may also provide a compelling basis for the development of innovative anti-fibrotic strategies.
In Arabidopsis thaliana, the stem cell niche (SCN) within the root apical meristem (RAM) is maintained by an intricate regulatory network that ensures optimal growth and high developmental plasticity. Yet, many aspects of this regulatory network of stem cell quiescence and replenishment are still not fully understood. Here, we investigate the interplay of the key transcription factors (TFs) BRASSINOSTEROID AT VASCULAR AND ORGANIZING CENTRE (BRAVO), PLETHORA 3 (PLT3) and WUSCHEL-RELATED HOMEOBOX 5 (WOX5) involved in SCN maintenance. Phenotypical analysis of mutants involving these TFs uncover their combinatorial regulation of cell fates and divisions in the SCN. Moreover, interaction studies employing fluorescence resonance energy transfer fluorescence lifetime imaging microscopy (FRET-FLIM) in combination with novel analysis methods, allowed us to quantify protein-protein interaction (PPI) affinities as well as higher-order complex formation of these TFs. We integrated our experimental results into a computational model, suggesting that cell type specific profiles of protein complexes and characteristic complex formation, that is also dependent on prion-like domains in PLT3, contribute to the intricate regulation of the SCN. We propose that these unique protein complex ‘signatures’ could serve as a read-out for cell specificity thereby adding another layer to the sophisticated regulatory network that balances stem cell maintenance and replenishment in the Arabidopsis root.