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Three-taxon statement analysis (3TA) is a method that may help to formalize the taxonomical intuition of the synapomorphy of the clade as a combination of its diagnostic traits, even if each trait, if taken separately, may be found in one or many other taxa of the same relationship. Using example based on the real morphological data, we are showing that 3TA can recognize clade in case of the complete lack of it synapomorphies, as optimized under the criterion of standard parsimony.
The contributions of Korean and Taiwanese authors to the many and varied formulations of interwar pan-Asianism have so far remained a relatively unexplored subject of scholarly research, despite an unbroken interest in the trajectory of state-based Japanese pan-Asianism. Focusing on Korean students and independence activists, this article discusses alternative configurations of regional unity and solidarity that emanated from the interactions among Korean, Taiwanese, and other Asian actors who resided in Tokyo during the 1910s and 1920s. When the ethnic-nationalist interpretations of the Wilsonian principle of self-determination failed to materialize, a portion of anti-colonial activists in Asia began to emphasize the need for solidarity by drawing on what they perceived as traditional and shared “Asian” values. While challenging the Western-dominated international order of nation-states that perpetuated imperialism, such notions of Asian solidarity at the same time served as an ideology of liberation from Japanese imperialism. Examining journals published by Korean students and activists, including The Asia Kunglun, this article adds another layer to the history of pan-Asianism from below, a perspective that has often been neglected within the larger context of scholarship on pan-Asianism and Japanese imperialism in Asia.
"European" interventions
(2017)
Am 6. Juli 1916 notierte Ludwig Wittgenstein in seinem Tagebuch: "Und insofern hat wohl auch Dostojewskij recht, wenn er sagt, dass der, welcher glücklich ist, den Zweck des Daseins erfüllt." Diese Aussage ist eingebettet in Überlegungen zur Beziehung von Ethik und Ästhetik in seinem Tagebuch, die später in den 'Tractatus logicophilosophicus' einfliessen (ab Satz 6.42). Die Figur Dostojewskijs, die am explizitesten solche Sätze aussprach, wie den oben zitierten, ist der Starez Sosima aus den 'Brüdern Karamasow'. Wittgenstein hat diesen Roman so oft gelesen, dass er ihn nahezu auswendig konnte, insbesondere die Reden des Starez Sosima. Obwohl Wittgenstein darauf bestand, dass Ethik "unaussprechbar" ist, deutet er an, dass Literatur das gute Leben "zeigen" kann. Somit überschreitet er die Grenzen der frühen analytischen Philosophie, die sich an mathematischen Wissenschaften orientierte und sich möglichst von der Kunst abzugrenzen suchte.
The asymmetric unit of the title compound, C21H28N4O, consists of two unique molecules linked by an O—H⋯N hydrogen bond. The conformation of both C=N bonds is E and the azomethine functional groups lie close to the plane of their associated benzene rings in each of the independent molecules. The dihedral angles between the two benzene rings are 83.14 (4) and 75.45 (4)°. The plane of the one of the N(CH3)2 units is twisted away from the benzene ring by 18.8 (2)°, indicating loss of conjugation between the lone electron pair and the benzene ring. In the crystal structure, O—H⋯N hydrogen bonds together with C—H⋯O hydrogen bonds link neighbouring supramolecular dimers into a three-dimensional network.
Mathematical models of virus dynamics have not previously acknowledged spatial resolution at the intracellular level despite substantial arguments that favor the consideration of intracellular spatial dependence. The replication of the hepatitis C virus (HCV) viral RNA (vRNA) occurs within special replication complexes formed from membranes derived from endoplasmatic reticulum (ER). These regions, termed membranous webs, are generated primarily through specific interactions between nonstructural virus-encoded proteins (NSPs) and host cellular factors. The NSPs are responsible for the replication of the vRNA and their movement is restricted to the ER surface. Therefore, in this study we developed fully spatio-temporal resolved models of the vRNA replication cycle of HCV. Our simulations are performed upon realistic reconstructed cell structures—namely the ER surface and the membranous webs—based on data derived from immunostained cells replicating HCV vRNA. We visualized 3D simulations that reproduced dynamics resulting from interplay of the different components of our models (vRNA, NSPs, and a host factor), and we present an evaluation of the concentrations for the components within different regions of the cell. Thus far, our model is restricted to an internal portion of a hepatocyte and is qualitative more than quantitative. For a quantitative adaption to complete cells, various additional parameters will have to be determined through further in vitro cell biology experiments, which can be stimulated by the results deccribed in the present study.
The Karl Schwarzschild Meeting 2017 (KSM2017) has been the third instalment of the conference dedicated to the great Frankfurter scientist, who derived the first black hole solution of Einstein's equations about 100 years ago.
The event has been a 5 day meeting in the field of black holes, AdS/CFT correspondence and gravitational physics. Like the two previous instalments, the conference continued to attract a stellar ensemble of participants from the world's most renowned institutions. The core of the meeting has been a series of invited talks from eminent experts (keynote speakers) as well as the presence of plenary research talks by students and junior speakers.
List of Conference photo and poster, Sponsors and funding acknowledgments, Committees and List of participants are available in this PDF.
The Cosmological Lithium Problem refers to the large discrepancy between the abundance of primordial 7Li predicted by the standard theory of Big Bang Nucleosynthesis and the value inferred from the so-called “Spite plateau” in halo stars. A possible explanation for this longstanding puzzle in Nuclear Astrophysics is related to the incorrect estimation of the destruction rate of 7Be, which is responsible for the production of 95% of primordial Lithium. While charged-particle induced reactions have mostly been ruled out, data on the 7Be(n,α) and 7Be(n,p) reactions are scarce or completely missing, so that a large uncertainty still affects the abundance of 7Li predicted by the standard theory of Big Bang Nucleosynthesis. Both reactions have been measured at the n_TOF facility at CERN, providing for the first time data in a wide neutron energy range.
In this work we present, for the first time, the non-perturbative renormalization for the unpolarized, helicity and transversity quasi-PDFs, in an RI′ scheme. The proposed prescription addresses simultaneously all aspects of renormalization: logarithmic divergences, finite renormalization as well as the linear divergence which is present in the matrix elements of fermion operators with Wilson lines. Furthermore, for the case of the unpolarized quasi-PDF, we describe how to eliminate the unwanted mixing with the twist-3 scalar operator.
We utilize perturbation theory for the one-loop conversion factor that brings the renormalization functions to the MS-scheme at a scale of 2 GeV. We also explain how to improve the estimates on the renormalization functions by eliminating lattice artifacts. The latter can be computed in one-loop perturbation theory and to all orders in the lattice spacing.
We apply the methodology for the renormalization to an ensemble of twisted mass fermions with Nf = 2 + 1 + 1 dynamical quarks, and a pion mass of around 375 MeV.
In this work the flexibility requirements of a highly renewable European electricity network that has to cover fluctuations of wind and solar power generation on different temporal and spatial scales are studied. Cost optimal ways to do so are analysed that include optimal distribution of the infrastructure, large scale transmission, storage, and dispatchable generators. In order to examine these issues, a model of increasing sophistication is built, first considering different flexibility classes of conventional generation, then adding storage, before finally considering transmission to see the effects of each.
To conclude, in this work it was shown that slowly flexible base load generators can only be used in energy systems with renewable shares of less than 50%, independent of the expansion of an interconnecting transmission network within Europe. Furthermore, for a system with a dominant fraction of renewable generation, highly flexible generators are essentially the only necessary class of backup generators. The total backup capacity can only be decreased significantly if interconnecting transmission is allowed, clearly favouring a European-wide energy network. These results are independent of the complexity level of the cost assumptions used for the models. The use of storage technologies allows to reduce the required conventional backup capacity further. This highlights the importance of including additional technologies into the energy system that provide flexibility to balance fluctuations caused by the renewable energy sources. These technologies could for example be advanced energy storage systems, interconnecting transmission in the electricity network, and hydro power plants.
It was demonstrated that a cost optimal European electricity system with almost 100% renewable generation can have total system costs comparable to today's system cost. However, this requires a very large transmission grid expansion to nine times the line volume of the present-day system. Limiting transmission increases the system cost by up to a third, however, a compromise grid with four times today's line volume already locks in most of the cost benefits. Therefore, it is very clear that by increasing the pan-European network connectivity, a cost efficient inclusion of renewable energies can be achieved, which is strongly needed to reach current climate change prevention goals.
It was also shown that a similarly cost efficient, highly renewable European electricity system can be achieved that considers a wide range of additional policy constraints and plausible changes of economic parameters.
A trimaculate male of the diplopod genus Apheloria Chamberlin (Polydesmida: Xystodesmidae/-inae: Apheloriini) from 1.3 km (0.8 mi) west of McKenney, Dinwiddie County (Co.), Virginia, is designated the Neotype of Julus virginiensis Drury 1770, thereby stabilizing the earliest name for a North American milliped and authenticating its prior assignment to this taxon. The existing concept of Apheloria is accepted in the absence of a revisionary treatment, and a modern description of A. v. virginiensis with gonopod drawings and color photos is provided. Drury’s original account and his letter to the Virginian who sent him the original specimens are quoted verbatim to eliminate future library searches. The specific name has been associated with at least three genera, and its confusing history is clarified by summarizing works in each. Authentic localities, mapped to the extent now possible, reveal a distribution south of the James River in piedmont and coastal Virginia that extends southwestward to the Blue Ridge foothills and at least as far south in North Carolina (NC) as Greensboro, the “Triangle” (Raleigh/Durham/Chapel Hill region), and Albemarle Sound in the east. Based on the holotypes, A. aspila and A. tigana, both by Chamberlin, are placed in synonymy under A. v. virginiensis (syns. nov.), and although its status is still under review, A. waccamana Chamberlin, whose type locality is Lake Waccamaw, Columbus Co., in southeastern NC, may be the correct name for today’s A. tigana. All samples so labeled must be reexamined for misidentifications of A. v. virginiensis.
Background: Invasive off- or on-pump cardiac surgery (elective and emergency procedures, excluding transplants are routinely performed to treat complications of ischaemic heart disease. Randomised controlled trials (RCT) evaluate the effectiveness of treatments in the setting of cardiac surgery. However, the impact of RCTs is weakened by heterogeneity in outcome measuring and reporting, which hinders comparison across trials. Core outcome sets (COS, a set of outcomes that should be measured and reported, as a minimum, in clinical trials for a specific clinical field) help reduce this problem. In light of the above, we developed a COS for cardiac surgery effectiveness trials.
Methods: Potential core outcomes were identified a priori by analysing data on 371 RCTs of 58,253 patients. We reached consensus on core outcomes in an international three-round eDelphi exercise. Outcomes for which at least 60% of the participants chose the response option "no" and less than 20% chose the response option "yes" were excluded.
Results: Eighty-six participants from 23 different countries involving adult cardiac patients, cardiac surgeons, anaesthesiologists, nursing staff and researchers contributed to this eDelphi. The panel reached consensus on four core outcomes: 1) Measure of mortality, 2) Measure of quality of life, 3) Measure of hospitalisation and 4) Measure of cerebrovascular complication to be included in adult cardiac surgery trials.
Conclusion: This study used robust research methodology to develop a minimum core outcome set for clinical trials evaluating the effectiveness of treatments in the setting of cardiac surgery. As a next step, appropriate outcome measurement instruments have to be selected.
The Gini index is a measure of the inequality of a distribution that can be derived from Lorenz curves. While commonly used in, e.g., economic research, it suffers from ambiguity via lack of Lorenz dominance preservation. Here, investigation of large sets of empirical distributions of incomes of the World’s countries over several years indicated firstly, that the Gini indices are centered on a value of 33.33% corresponding to the Gini index of the uniform distribution and secondly, that the Lorenz curves of these distributions are consistent with Lorenz curves of log-normal distributions. This can be employed to provide a Lorenz dominance preserving equivalent of the Gini index. Therefore, a modified measure based on log-normal approximation and standardization of Lorenz curves is proposed. The so-called UGini index provides a meaningful and intuitive standardization on the uniform distribution as this characterizes societies that provide equal chances. The novel UGini index preserves Lorenz dominance. Analysis of the probability density distributions of the UGini index of the World’s counties income data indicated multimodality in two independent data sets. Applying Bayesian statistics provided a data-based classification of the World’s countries’ income distributions. The UGini index can be re-transferred into the classical index to preserve comparability with previous research.
Background: Modulation of cortical excitability by transcranial magnetic stimulation (TMS) is used for investigating human brain functions. A common observation is the high variability of long-term depression (LTD)-like changes in human (motor) cortex excitability. This study aimed at analyzing the response subgroup distribution after paired continuous theta burst stimulation (cTBS) as a basis for subject selection.
Methods: The effects of paired cTBS using 80% active motor threshold (AMT) in 31 healthy volunteers were assessed at the primary motor cortex (M1) corresponding to the representation of the first dorsal interosseous (FDI) muscle of the left hand, before and up to 50 min after plasticity induction. The changes in motor evoked potentials (MEPs) were analyzed using machine-learning derived methods implemented as Gaussian mixture modeling (GMM) and computed ABC analysis.
Results: The probability density distribution of the MEP changes from baseline was tri-modal, showing a clear separation at 80.9%. Subjects displaying at least this degree of LTD-like changes were n = 6 responders. By contrast, n = 7 subjects displayed a paradox response with increase in MEP. Reassessment using ABC analysis as alternative approach led to the same n = 6 subjects as a distinct category.
Conclusion: Depressive effects of paired cTBS using 80% AMT endure at least 50 min, however, only in a small subgroup of healthy subjects. Hence, plasticity induction by paired cTBS might not reflect a general mechanism in human motor cortex excitability. A mathematically supported criterion is proposed to select responders for enrolment in assessments of human brain functional networks using virtual brain lesions.
Three basic elements should be part of researching in contexts where power asymmetries and colonial connotations are relevant (which applies to many, if not the majority of research contexts in conflict studies): a thorough reflexivity of the researcher’s own role and social conditioning, the construction of research as a political act as it intervenes in scientific and political discourse, and the fact that (especially empirical) research is a product of many (Kaltmeier 2012, Abu Lughod 1991)...