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The freeze out of the expanding systems, created in relativistic heavy ion collisions, is discussed. We combine kinetic freeze out equations with Bjorken type system expansion into a unified model. The important feature of the proposed scenario is that physical freeze out is completely finished in a finite time, which can be varied from 0 (freeze out hypersurface) to infinit. The dependence of the post freeze out distribution function on the freeze out time will be studied. Model allows analytical analyses for the simplest systems such as pion gas. We shall see that the basic freeze out features, pointed out in the earlier works, are not smeared out by the expansion of the system. The entropy evolution in such a scenario is also studied.
The elliptic flow for Lambda hyperons and K0s mesons was measured by the NA49 experiment in semicentral Pb+Pb collisions at 158A GeV. The standard method of correlating particles with an event plane has been used. Measurements of v2 near mid-rapidity are reported as a function of centrality, rapidity and transverse momentum. Elliptic flow of Lambda and K0s particles increases both with the impact parameter and with the transverse momentum. It is compared with v2 for pions and protons as well as with various model predictions. The NA49 results are compared with data from NA45/CERES and STAR experiments.
The effects of the onset of deconfinement on longitudinal and transverse flow are studied. First, we analyze longitudinal pion spectra from Elab = 2A GeV to √sNN = 200 GeV within Landau’s hydrodynamical model and the UrQMD transport approach. From the measured data on the widths of the pion rapidity spectra, we extract the sound velocity c2s in the early stage of the reactions. It is found that the sound velocity has a local minimum (indicating a softest point in the equation of state, EoS) at Ebeam = 30A GeV. This softening of the EoS is compatible with the assumption of the formation of a mixed phase at the onset of deconfinement. Furthermore, the energy excitation function of elliptic flow (v2) from Ebeam = 90A MeV to √sNN = 200 GeV is explored within the UrQMD framework and discussed in the context of the available data. The transverse flow should also be sensitive to changes in the equation of state. Therefore, the underestimation of elliptic flow by the UrQMD model calculation above Elab = 30A GeV might also be explained by assuming a phase transition from a hadron gas to the quark gluon plasma around this energy. This would be consistent with the model calculations, indicating a transition from hadronic matter to “string matter” in this energy range.
The energy dependence of multiplicity fluctuations was studied for the most central Pb+Pb collisions at 20A, 30A, 40A, 80A and 158A GeV by the NA49 experiment at the CERN SPS. The multiplicity distribution for negatively and positively charged hadrons is significantly narrower than Poisson one for all energies. No significant structure in energy dependence of the scaled variance of multiplicity fluctuations is observed. The measured scaled variance is lower than the one predicted by the grand-canonical formulation of the hadron-resonance gas model. The results for scaled variance are in approximate agreement with the string-hadronic model UrQMD.
A new SPS programme
(2006)
A new experiemntal program to study hadron production in hadron-nucleus and nucleus-nucleus collisions at the CERN SPS has been recently proposed by the NA49-future collaboration. The physics goals of the program are: (i) search for the critical point of strongly interacting matter and a study of the properties of the onset of deconfinemnt in nucleus-nucleus collisions, (ii) measurements of correlations, fluctuations and hadron spectra at high transverse momentum in proton-nucleus collisions needed as for better understanding of nucleus-nucleus results, (iii) measurements of hadron production in hadron-nucleus interactions needed for neutrino (T2K) and cosmic-ray (Pierre Auger Observatory and KASCADE) expriments. The physics of the nucleus-nucleus program is reviewed in this presentation.
Effects of BPA in snails
(2006)
It is an ethical requirement that new findings be presented in light of and in conjunction with a balanced evaluation of the current knowledge and published literature. We believe that Oehlmann et al. (2006) violated this general principle in several ways. For example, the authors inferred that prosobranch snails have a functional estrogen receptor and therefore a much higher sensitivity to estrogens and endocrine-disrupting compounds (EDCs) than other species previously reported in the literature. We found several other problems in their article...
We welcome critical appraisals that help to provide balance; however, Dietrich et al. gave an unjustified reproach. We feel that Dietrich’s position is severely compromised because he serves as an expert for the bisphenol A (BPA) Industry Group (Brussels, Belgium). We would like to respond to the issues raised by Dietrich et al., as well as to their oversights and inappropriate interpretations of our findings...
Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife. Given the complexity of endocrine systems, there are many ways in which endocrine-disrupting chemicals (EDCs) can affect the body’s signaling system, and this makes unraveling the mechanisms of action of these chemicals difficult. A major concern is that some of these EDCs appear to be biologically active at extremely low concentrations. There is growing evidence to indicate that the guiding principle of traditional toxicology that “the dose makes the poison” may not always be the case because some EDCs do not induce the classical dose–response relationships. The European Union project COMPRENDO (Comparative Research on Endocrine Disrupters—Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds) therefore aims to develop an understanding of potential health problems posed by androgenic and antiandrogenic compounds (AACs) to wildlife and humans by focusing on the commonalities and differences in responses to AACs across the animal kingdom (from invertebrates to vertebrates).
Polyploidy is common in higher eukaryotes, especially in plants, but it is generally assumed that most prokaryotes contain a single copy of a circular chromosome and are therefore monoploid. We have used two independent methods to determine the genome copy number in halophilic archaea, 1) cell lysis in agarose blocks and Southern blot analysis, and 2) Real-Time quantitative PCR. Fast growing H. salinarum cells contain on average about 25 copies of the chromosome in exponential phase, and their ploidy is downregulated to 15 copies in early stationary phase. The chromosome copy number is identical in cultures with a twofold lower growth rate, in contrast to the results reported for several other prokaryotic species. Of three additional replicons of H. salinarum, two have a low copy number that is not growth-phase regulated, while one replicon even shows a higher degree of growth phase-dependent regulation than the main replicon. The genome copy number of H. volcanii is similarly high during exponential phase (on average 18 copies/cell), and it is also downregulated (to 10 copies) as the cells enter stationary phase. The variation of genome copy numbers in the population was addressed by fluorescence microscopy and by FACS analysis. These methods allowed us to verify the growth phase-dependent regulation of ploidy in H. salinarum, and they revealed that there is a wide variation in genome copy numbers in individual cells that is much larger in exponential than in stationary phase. Our results indicate that polyploidy might be more widespread in archaea (or even prokaryotes in general) than previously assumed. Moreover, the presence of so many genome copies in a prokaryote raises questions about the evolutionary significance of this strategy.
Im Jahr 2003 begann die HNO-Universitätsklinik Frankfurt / Main mit der Einführung eines Qualitätsmanagement-Systems, die im August 2005 zur erfolgreichen Zertifizierung nach der vom Klinikumsvorstand geforderten DIN EN ISO 9001:2000 führte. Ziele unseres Qualitätsmanagements waren die Optimierung der internen Betriebsabläufe und die Standardisierung von Arbeitsvorgängen unter Einbeziehung von logistischen Schnittstellen mit externen Strukturen unter Berücksichtigung der besonderen Anforderungen einer Universitätsklinik. Neben einer grundsätzlichen Prüfung und Optimierung sämtlicher Organisationsabläufe wurden für die Kernprozesse unserer Klinik Zielvorgaben festgelegt. Diese Ziele betrafen die Qualität der Arbeitsabläufe für alle Bereiche der HNO-ärztlichen ambulanten und stationären Versorgung ebenso, wie Aufgaben in Forschung und Lehre, die durch ein Ausbildungscurriculum für Mitarbeiter und Sudenten abgebildet wurde. Es wurden aber auch Serviceaspekte, wie Terminvergabe und Befundübermittlung, sowie ökonomische und wirtschaftliche Aspekte unserer Arbeit optimiert. Durch Umstrukturierung und Neuorganisation konnte die Effizienz der Arbeitsabläufe deutlich gesteigert werden, wovon vor allem Patienten und Mitarbeiter erheblich profitieren. Die Einführung eines Qualitätsmanagementsystems in der Frankfurter HNO-Universitätsklinik war zunächst mit einem entsprechenden Arbeitsaufwand verbunden und erforderte ein Umdenken in den einzelnen Funktionsbereichen. Insgesamt überwiegt der positive Einfluss auf die Struktur und Arbeitsabläufe, sodass die Umsetzung eines Qualitätsmanagementsystems in der Universitätsklinik empfehlenswert ist.
k-MED entwickelte sich von einem fachbezogenen Projekt im Jahr 1999 zu einem e-Learning-Dienstleister mit umfangreichen Lehr-Lernangeboten sowie einer technischen und organisatorischen Infrastruktur für Autoren und Nutzer. Es bietet heute – Mitte 2006 – 5000 Studierenden, v.a. der Humanmedizin, ca. 170 Lernkurse aus 16 medizinischen Fächern. Das Projekt umfasst erfahrenes Fachpersonal und nutzt eine eigene Online-Autorenumgebung sowie eine internetbasierte Lernplattform, deren Funktionalitäten in Abstimmung mit evaluierten Lehr- und Lern-Szenarien ständig weiter entwickelt werden. Die wichtigste Aufgabe ist die Vollversorgung von Bildungseinrichtungen, darunter vor allem medizinische Fakultäten, mit Lehr-Lern- und Kommunikationsinstrumenten. Aktuelle Informationen sind zu finden unter http://www.k-med.org.
Background: The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection. Most poxvirus genomes are relatively A/T-rich, which may indicate APOBEC3G-induced mutational pressure. In addition, poxviruses replicate exclusively in the cytoplasm where APOBEC3G is located. It was therefore tempting to analyze whether vaccinia virus replication is affected by APOBEC3G.
Results: The replication of vaccinia virus, a prototype poxvirus, was not, however, inhibited in APOBEC3G-expressing cells, nor did other members of the APOBEC3 family alter vaccinia virus replication. HIV counteracts APOBEC3G by inducing its degradation. However, Western blot analysis showed that the levels of APOBEC3G protein were not affected by vaccinia virus infection.
Conclusion: The data indicate that APOBEC3G is not a restriction factor for vaccinia virus replication nor is vaccinia virus able to degrade APOBEC3G.
Following publication of the data presented by von Minckwitz and colleagues it has been brought to our attention that some patients should be scored differently. Stable disease was seen in three of the eighteen patients instead of two of the eighteen patients: one patient with transitional cell carcinoma treated at 4 µg/kg scFv(FRP5)-ETA per day, and two breast cancer patients treated at 4 and 12.5 µg/kg scFv(FRP5)-ETA per day. Disease progression occured in 9 of the eighteen patients evaluated (see corrected Table 2 overleaf). This does not affect the conclusions of our study. In addition we would like to correct the following errors: patient IDs for patients U01 and U02 in the original Table 2 were interchanged. In addition, patient N03 had a grade 3 elevation of gamma-glutamyl transferase, and not grade 2 (see corrected Table 2 overleaf).
Im Februar ist Universitätspräsident Prof. Rudolf Steinberg mit großer Mehrheit für weitere sechs Jahre in seinem Amt bestätigt worden. Zu Beginn seiner zweiten Amtszeit in diesem Monat wirft er im Gespräch mit dem UniReport einen Blick zurück auf die wichtigsten Entwicklungen und Ereignisse an der Goethe-Universität in seiner ersten Amtszeit und zeigt, wohin die Reise in den kommenden sechs Jahren gehen soll.
Im Mittelpunkt magnetischer Momente : Frankfurt führt das europäische Zentrum für Kernspinresonanz
(2006)
Die Kernspinresonanz (NMR) ist ein Phänomen, das einen präzisen Blick in das Innere der Materie erlaubt. Für Chemiker und Biologen hat ihre Messung im Laufe der vergangenen 50 Jahre immer mehr Bedeutung gewonnen. Die analytische Präzision hat ihren Preis: Ein hochauflösendes NMR-Spektrometer kostet 6,4 Millionen Euro. Auch deshalb haben sich fünf europäische NMR-Zentren jetzt zu einem Großforschungsverbund zusammengeschlossen; unter Federführung Frankfurts und gefördert von der Europäischen Union – damit die Spitzenstellung Europas auf dem Gebiet der NMR-Forschung erhalten und ausgebaut werden kann.
Wieviel Sexualität verträgt eine Universität? Wieviel Sexualität braucht eine Universität? Natürlich nur auf streng wissenschaftlicher Ebene. Seit Monaten ist das am Zentrum für Gesundheitswissenschaften des Klinikums angesiedelte Institut für Sexualwissenschaft in der Diskussion. Der Grund dafür: das Ausscheiden des derzeitigen Direktors, Prof. Volkmar Sigusch, im Herbst. Zu eng scheint der Bestand des Instituts mit der Person des anerkannten Fachmanns mit weltweitem Renommee verknüpft.
Seine seit Jahren herausragenden Leistungen in der Vermittlung wissenschaftlicher Arbeit in der Öffentlichkeit findet mit der Zuerkennung des mit 50.000 Euro dotierten »Communicator-Preises – Wissenschaftspreis des Stifterverbandes« eine verdiente Würdigung. Prof. Friedemann Schrenk ist der diesjährige Preisträger des renommierten, seit 1999 vergebenen Preises, der ihm an seinem 50. Geburtstag von den Präsidenten der Deutschen Forschungsgemeinschaft (DFG) und des Stifterverbandes für die Deutsche Wissenschaft am 18. Juli 2006 in einer Festveranstaltung während des Wissenschaftssommers in München verliehen wird.
Prof. Wolf Lauterbach : 65. Geburtstag [des Professors für klinische Psychologie und Psychotherapie]
(2006)
Der Zugang des Frankfurter Afrikaforschers Leo Frobenius zu Afrika war die Expedition. In insgesamt zwölf »Deutschen Inner-Afrika Expeditionen «, die teilweise vom exilierten Kaiser Wilhelm II. finanziert wurden, bereiste und erforschte er weite Gebiete des Kontinents.