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The catalogue of species-group names of nine coprine genera (Coleoptera: Scarabaeidae: Scarabaeinae: Coprini), published earlier this year, is updated and revised. Presented are species-group taxa overlooked in compiling the catalogue and new species-group taxa described in 2020, i.e. after the cut-off date of the catalogue.
Presented are species-group names published in the nine coprine genera (Coleoptera: Scarabaeidae: Scarabaeinae: Coprini) having only one lateral carina on each elytron. The data include authorships, dates and pages of original descriptions, geographic distributions, and references to works pertinent to the topic.
Geoffrey Burnstock will be remembered as the scientist who set up an entirely new field of intercellular communication, signaling via nucleotides. The signaling cascades involved in purinergic signaling include intracellular storage of nucleotides, nucleotide release, extracellular hydrolysis, and the effect of the released compounds or their hydrolysis products on target tissues via specific receptor systems. In this context ectonucleotidases play several roles. They inactivate released and physiologically active nucleotides, produce physiologically active hydrolysis products, and facilitate nucleoside recycling. This review briefly highlights the development of our knowledge of two types of enzymes involved in extracellular nucleotide hydrolysis and thus purinergic signaling, the ectonucleoside triphosphate diphosphohydrolases, and ecto-5′-nucleotidase.
Highlights
• PUR, PVC and PLA microplastics affect life-history parameters of Daphnia magna.
• Natural kaolin particles are less toxic than microplastics.
• Microplastic toxicity is material-specific, e.g. PVC is most toxic on reproduction.
• In case of PVC, plastic chemicals are the main driver of microplastic toxicity.
• PLA bioplastics are similarly toxic as conventional plastics.
Abstract
Given the ubiquitous presence of microplastics in aquatic environments, an evaluation of their toxicity is essential. Microplastics are a heterogeneous set of materials that differ not only in particle properties, like size and shape, but also in chemical composition, including polymers, additives and side products. Thus far, it remains unknown whether the plastic chemicals or the particle itself are the driving factor for microplastic toxicity. To address this question, we exposed Daphnia magna for 21 days to irregular polyvinyl chloride (PVC), polyurethane (PUR) and polylactic acid (PLA) microplastics as well as to natural kaolin particles in high concentrations (10, 50, 100, 500 mg/L, ≤ 59 μm) and different exposure scenarios, including microplastics and microplastics without extractable chemicals as well as the extracted and migrating chemicals alone. All three microplastic types negatively affected the life-history of D. magna. However, this toxicity depended on the endpoint and the material. While PVC had the largest effect on reproduction, PLA reduced survival most effectively. The latter indicates that bio-based and biodegradable plastics can be as toxic as their conventional counterparts. The natural particle kaolin was less toxic than microplastics when comparing numerical concentrations. Importantly, the contribution of plastic chemicals to the toxicity was also plastic type-specific. While we can attribute effects of PVC to the chemicals used in the material, effects of PUR and PLA plastics were induced by the mere particle. Our study demonstrates that plastic chemicals can drive microplastic toxicity. This highlights the importance of considering the individual chemical composition of plastics when assessing their environmental risks. Our results suggest that less studied polymer types, like PVC and PUR, as well as bioplastics are of particular toxicological relevance and should get a higher priority in ecotoxicological studies.
In higher concentrations, the blood pressure regulating hormone angiotensin II leads to vasoconstriction, hypertension, and oxidative stress by activating NADPH oxidases which are a major enzymatic source of reactive oxygen species (ROS). With the help of knockout animals, the impact of the three predominant NADPH oxidases present in the kidney, i.e., Nox1, Nox2 and Nox4 on angiotensin II-induced oxidative damage was studied. Male wildtype (WT) C57BL/6 mice, Nox1-, Nox2- and Nox4-deficient mice were equipped with osmotic minipumps, delivering either vehicle (PBS) or angiotensin II, for 28 days. Angiotensin II increased blood pressure and urinary albumin levels significantly in all treated mouse strains. In Nox1 knockout mice these increases were significantly lower than in WT, or Nox2 knockout mice. In WT mice, angiotensin II also raised systemic oxidative stress, ROS formation and DNA lesions in the kidney. A local significantly increased ROS production was also found in Nox2 and Nox4 knockout mice but not in Nox1 knockout mice who further had significantly lower systemic oxidative stress and DNA damage than WT animals. Nox2 and Nox4 knockout mice had increased basal DNA damage, concealing possible angiotensin II-induced increases. In conclusion, in the kidney, Nox1 seemed to play a role in angiotensin II-induced DNA damage.
Personalized campaign styles are of increasing importance in contemporary election campaigns at all levels of politics. Surprisingly, we know little about their implications for the behavior of successful candidates once they take public office. This paper aims to fill this gap in empirical and theoretical ways. It shows that campaign personalization results in legislative personalization. Legislators that ran personalized campaigns are found to be more likely to deviate in roll call votes and to take independent positions on the floor. These findings result from a novel dataset that matches survey evidence on candidates’ campaign styles in the 2009 German Federal Elections with the legislative behavior of successful candidates in the 17th German Bundestag (2009–2013). Combining data from the campaign and legislative arenas allows us to explore the wider consequences of campaign personalization.
In a time when 'internationalization' and 'diversity' have become key areas universities are expected to excel in, it may seem an almost self-evident endeavor to install a memorial for a figure as influential and internationalist as Du Bois, whose connection to the Humboldt University outlasted two ideologically very different political systems. Planned to be positioned in the ground floor of the main building, the memorial, which will start production as soon as the last funding has been secured, reveals an image right at its center that "exist[s] in virtually every student's life and family album, and commonly serve[s] as vehicle[s] of recognition, remembrance and commemoration": the class photograph. What are the main considerations underlying the W. E. B. Du Bois Memorial's concept and design? How has it evolved so far? And what can such a memorial realistically achieve?
Aging is a one-way process associated with profound structural and functional changes in the organism. Indeed, the neuromuscular system undergoes a wide remodeling, which involves muscles, fascia, and the central and peripheral nervous systems. As a result, intrinsic features of tissues, as well as their functional and structural coupling, are affected and a decline in overall physical performance occurs. Evidence from the scientific literature demonstrates that senescence is associated with increased stiffness and reduced elasticity of fascia, as well as loss of skeletal muscle mass, strength, and regenerative potential. The interaction between muscular and fascial structures is also weakened. As for the nervous system, aging leads to motor cortex atrophy, reduced motor cortical excitability, and plasticity, thus leading to accumulation of denervated muscle fibers. As a result, the magnitude of force generated by the neuromuscular apparatus, its transmission along the myofascial chain, joint mobility, and movement coordination are impaired. In this review, we summarize the evidence about the deleterious effect of aging on skeletal muscle, fascial tissue, and the nervous system. In particular, we address the structural and functional changes occurring within and between these tissues and discuss the effect of inflammation in aging. From the clinical perspective, this article outlines promising approaches for analyzing the composition and the viscoelastic properties of skeletal muscle, such as ultrasonography and elastography, which could be applied for a better understanding of musculoskeletal modifications occurring with aging. Moreover, we describe the use of tissue manipulation techniques, such as massage, traction, mobilization as well as acupuncture, dry needling, and nerve block, to enhance fascial repair.
Background: Berotralstat (BCX7353) is an oral, once-daily inhibitor of plasma kallikrein in development for the prophylaxis of hereditary angioedema (HAE) attacks.
Objective: Our aim was to determine the efficacy, safety, and tolerability of berotralstat in patients with HAE over a 24-week treatment period (the phase 3 APeX-2 trial).
Methods: APeX-2 was a double-blind, parallel-group study that randomized patients at 40 sites in 11 countries 1:1:1 to receive once-daily berotralstat in a dose of 110 mg or 150 mg or placebo (Clinicaltrials.gov identifier NCT03485911). Patients aged 12 years or older with HAE due to C1 inhibitor deficiency and at least 2 investigator-confirmed HAE attacks in the first 56 days of a prospective run-in period were eligible. The primary efficacy end point was the rate of investigator-confirmed HAE attacks during the 24-week treatment period.
Results: A total of 121 patients were randomized; 120 of them received at least 1 dose of the study drug (n = 41, 40, and 39 in the 110-mg dose of berotralstat, 150-mg of dose berotralstat, and placebo groups, respectively). Berotralstat demonstrated a significant reduction in attack rate at both 110 mg (1.65 attacks per month; P = .024) and 150 mg (1.31 attacks per month; P < .001) relative to placebo (2.35 attacks per month). The most frequent treatment-emergent adverse events that occurred more with berotralstat than with placebo were abdominal pain, vomiting, diarrhea, and back pain. No drug-related serious treatment-emergent adverse events occurred.
Conclusion: Both the 110-mg and 150-mg doses of berotralstat reduced HAE attack rates compared with placebo and were safe and generally well tolerated. The most favorable benefit-to-risk profile was observed at a dose of 150 mg per day.
This article examines whether autonomy as an educational aim should be defended at the global scale. It begins by identifying the normative issues at stake in global autonomy education by distinguishing them from the problems of autonomy education in multicultural nation-states. The article then explains why a planet-wide expansion of the ideal of autonomy is conceivable on the condition that the concept of autonomy is widened in a way that renders its precise meaning flexibly adjustable to a variety of distinct social and cultural contexts. A context-transcendent, core meaning of autonomy remains in place, however, according to which a person is only autonomous if she relates to the values and goals that direct her life in a way so that she sees them as her own and is able to identify and critically assess her principal reasons for action. Finally, the article addresses two challenges to the global expansion of autonomy education: the objection that autonomy is presently not the most important educational aim and the objection that global autonomy education is a form of cultural imperialism. It finds both objections wanting.
The purpose of this study was to examine the psychometric properties (i.e., factorial validity, measurement invariance, and reliability) of the Grit-Original scale (Grit-O) within the Netherlands. The Grit-O scale was subjected to a competing measurement modeling strategy that sequentially compared both independent cluster model confirmatory factor analytical- and exploratory structural equation modeling approaches. The results showed that both a two first order, bi-factor structure as well as a less restrictive two factor ESEM factorial structure best-fitted the data. The instrument showed to be reliable at both a lower- (Cronbach’s alpha) and upper-level (composite reliability) limit. However, measurement invariance between genders could only be established for the B-ICM-CFA model. Finally, concurrent validity was established through relating the GRIT-O to task performance. The linear use of the Grit-O scale should therefore carefully be considered.
Despite the popularity of the term Positive Psychological Coaching within the literature, there is no consensus as to how it should be defined (framed) or what the components of a positive coaching “model” should include. The aim of this systematic review was to define positive psychological coaching and to construct a clear demarcated positive psychological coaching model based on the literature. A systematic literature review led to the extraction of 2,252 records. All records were screened using specific inclusion/exclusion criteria, which resulted in the exclusion of records based on duplicates (n = 1,232), titles (n = 895), abstracts (n = 78), and criteria violations (n = 23). Twenty-four academic, peer-reviewed publications on positive psychological coaching were included. Data relating to conceptual definitions and coaching models/phases/frameworks were extracted and processed through thematic content analysis. Our results indicate that positive psychological coaching can be defined as a short to medium term professional, collaborative relationship between a client and coach, aimed at the identification, utilization, optimization, and development of personal strengths and resources in order to enhance positive states, traits and behaviors. Utilizing Socratic goal setting and positive psychological evidence-based approaches to facilitate personal growth, optimal functioning, enhanced wellbeing, and the actualization of people's potential. Further, eight critical components of a positive psychological coaching model were identified and discussed. The definition and coaching process identified in this study will provide coaches with a fundamental positive psychological framework for optimizing people's potential.
Editorial: Positive organizational interventions: contemporary theories, approaches and applications
(2020)
The purpose of this study was to identify distinctive mental health profiles for industrial psychologists based on the Mental Health Continuum. Further, it aimed to determine how these profiles differ with respect to work-role fit, meaningfulness and work engagement. It also aimed to investigate whether industrial psychologists within managerial or specialist differ in respect of different types of mental health. An online cross-sectional survey design was employed to draw a census sample (n = 274) from all South African industrial psychologists. A biographical questionnaire, the Work-Role Fit Scale, the Psychological Meaningfulness Scale, the Work Engagement Scale, and the Mental Health Continuum–Short Form were administered. Descriptive statistics, correlations, latent profile analysis, MANOVAs and ANOVAs were computed. Three mental health profiles for industrial psychologists were identified: languishing, moderately mentally healthy and flourishing. Significant differences between the three mental health profiles and experiences of meaningful work-role fit and work engagement were found, but not between experiences of managerial roles. The results show that individuals with different mental health profiles, experience work and its related outcomes, differently. Therefore, in order to enhance meaningful work-role fit and work engagement of industrial psychologists, a one-size-fits-all model may not be appropriate.
This Dissertation deals with the development of FAIR-relevant X-ray diagnostics based on the interaction of lasers and particle beams with matter. The associated experimental methods are supposed to be employed in the HIHEX-experiments in the HHT-cave of the GSI Helmholtz Center for Heavy-Ion Research GmbH (GSI) in Phase-0 and in the APPA-cave at the Facility for Antiproton and Ion Research in Darmstadt, Germany.
Diagnostic of high aerial density targets that will be used in FAIR experiments demands intense and highly penetrating X-ray sources. Laser generated well-directe relativistic electron beams that interact with high Z materials is an excellent tool for generation of short-pulse high luminous sources of MeV-gammas.
In pilot experiments carried out at the PHELIX laser system, GSI Darmstadt, relativistic electrons were produced in a long scale plasma of near critical electron density (NCD) by the mechanism of the direct laser acceleration (DLA). Low density polymer foam layers preionised by a well-defined nanosecond laser pulse were used as NCD targets. The analysis of the measured electron spectra showed up to 10- fold increase of the electron "temperature" from T_Hot = 1–2 MeV, measured for the case of the interaction of 1–2 ×10^19 Wcm^(−2) ps-laser pulse with a planar foil, up to 14 MeV for the case when the relativistic laser pulse propagates through the by a ns-pulse preionised foam layer. In this case, up to 80–90 MeV electron energy was registered. An increase of the electron energy was accompanied by a strong increase of the number of relativistic electrons and well-defined directionality of the relativistic electron beam measured to be (12 ±1)° (FWHM). This directionality increases the gamma flux on target by far compared to the soft X-ray sources.
Additionally to laser based active diagnostics, passive techniques involving inherent X-ray fluorescence radiation of projectile and target emitted during heavy-ion target interaction can be used to measure the ion beam distribution on shot. This information is of great importance, since the target size is chosen to be smaller than the beam focus in order to ensure homogeneous heating of the HIHEX-target by the ion beam. High amounts of parasitic radiation and activation of experimental equipment is expected for experiments at the APPA-cave. For this reason, all electronic devices must be placed at a safe distance to the target chamber. In order to transport the signal over a large distance, the X-ray image of the target irradiated by heavy-ions has to be converted into an optical one.
For these purposes, the X-ray Conversion to Optical radiation and Transport (XCOT)-system was developed in the frame of a BMBF-project and commissioned in two beamtimes at the UNILAC, GSI during this work.
In experiments, we observed intense radiation of target atoms (K-shell transitions in Cu at 8–8.3 keV and L-shell transition in Ta) ionised in collisions with heavy ions as well as Doppler-shifted L-shell transitions of Au-projectiles passing through targets. This radiation can be used for monochromatic (dispersive elements like bent crystals) or polychromatic (pinhole) 2D X-ray mapping of the ion beam intensity distribution in the interaction region during the beam-target interaction. We measured the efficiency of the X-ray photon production depending on the target thickness and the number of ions passing through the target. The spatial resolution of the XCOT-system based on the multi-pinhole camera was measured to be (91±17) μm for the image magnification factor M = 2. It was considerably improved by application of a toroidally bent quartz crystal and reached 30 μm at M = 6. This resolution is optimal to image the distribution of a 1mm in diameter ion beam. As next step, the XCOT-system will be tested during the SIS18 beam-time at the HHT-experimental area.
A systematic review on the burden of illness in individuals with tuberous sclerosis complex (TSC)
(2020)
Objective: This review will summarize current knowledge on the burden of illness (BOI) in tuberous sclerosis complex (TSC), a multisystem genetic disorder manifesting with hamartomas throughout the body, including mainly the kidneys, brain, skin, eyes, heart, and lungs.
Methods: We performed a systematic analysis of the available literature on BOI in TSC according to the PRISMA guidelines. All studies irrespective of participant age that reported on individual and societal measures of disease burden (e.g. health care resource use, costs, quality of life) were included.
Results: We identified 33 studies reporting BOI in TSC patients. Most studies (21) reported health care resource use, while 14 studies reported quality of life and 10 studies mentioned costs associated with TSC. Only eight research papers reported caregiver BOI. Substantial BOI occurs from most manifestations of the disorder, particularly from pharmacoresistant epilepsy, neuropsychiatric, renal and skin manifestations. While less frequent, pulmonary complications also lead to a high individual BOI. The range for the mean annual direct costs varied widely between 424 and 98,008 International Dollar purchasing power parities (PPP-$). Brain surgery, end-stage renal disease with dialysis, and pulmonary complications all incur particularly high costs. There is a dearth of information regarding indirect costs in TSC. Mortality overall is increased compared to general population; and most TSC related deaths occur as a result of complications from seizures as well as renal complications. Long term studies report mortality between 4.8 and 8.3% for a follow-up of 8 to 17.4 years.
Conclusions: TSC patients and their caregivers have a high burden of illness, and TSC patients incur high costs in health care systems. At the same time, the provision of inadequate treatment that does not adhere to published guidelines is common and centralized TSC care is received by no more than half of individuals who need it, especially adults. Further studies focusing on the cost effectiveness and BOI outcomes of coordinated TSC care as well as of new treatment options such as mTOR inhibitors are necessary.
The National Institutes of Health Stroke Scale (NIHSS) score is the most frequently used score worldwide for assessing the clinical severity of a stroke. Prior research suggested an association between acute symptomatic seizures after stroke and poorer outcome. We determined the frequency of acute seizures after ischemic stroke in a large population-based registry in a central European region between 2004 and 2016 and identified risk factors for acute seizures in univariate and multivariate analyses. Additionally, we determined the influence of seizures on morbidity and mortality in a matched case–control design. Our analysis of 135,117 cases demonstrated a seizure frequency of 1.3%. Seizure risk was 0.6% with an NIHSS score at admission <3 points and increased up to 7.0% with >31 score points. Seizure risk was significantly higher in the presence of acute non-neurological infections (odds ratio: 3.4; 95% confidence interval: 2.8–4.1). A lower premorbid functional level also significantly increased seizure risk (OR: 1.7; 95%CI: 1.4–2.0). Mortality in patients with acute symptomatic seizures was almost doubled when compared to controls matched for age, gender, and stroke severity. Acute symptomatic seizures increase morbidity and mortality in ischemic stroke. Their odds increase with a higher NIHSS score at admission.
Recent data have suggested that performing recanalizing therapies in ischemic stroke might lead to an increased risk of acute symptomatic seizures. This applies to both intravenous thrombolysis and mechanical thrombectomy. We therefore determined the frequency of acute symptomatic seizures attributable to these two recanalization therapies using a large, population-based stroke registry in Central Europe. We performed two matched 1:1 case–control analyses. In both analyses, patients were matched for age, stroke severity on admission and pre-stroke functional status. The first analysis compared patients treated with intravenous thrombolysis to a non-recanalization control group. To isolate the effect of mechanical thrombectomy, we compared patients with both mechanical thrombectomy and intravenous thrombolysis to those with only intravenous thrombolysis treatment in a second analysis. From 135,117 patients in the database, 13,356 patients treated with only intravenous thrombolysis, and 1013 patients treated with both intravenous thrombolysis and mechanical thrombectomy were each matched to an equivalent number of controls. Patients with intravenous thrombolysis did not suffer from clinically apparent acute symptomatic seizures significantly more often than non-recanalized patients (treatment = 199; 1.5% vs. control = 237; 1.8%, p = 0.07). Mechanical thrombectomy in addition to intravenous thrombolysis also was not associated with an increased risk of acute symptomatic seizures, as the same number of patients suffered from seizures in the treatment and control group (both n = 17; 1.7%, p = 1). In a large population-based stroke registry, the frequency of clinically apparent acute symptomatic seizures was not increased in patients who received either intravenous thrombolysis alone or in conjunction with mechanical thrombectomy.
Evidence is increasingly pointing towards a significant global decline in biodiversity. The drivers of this decline are numerous, including habitat change and overexploitation, rapid deforestation, pollution, exotic species and disease, and finally climate change as an emerging driver of biodiversity change (Nakamura, et al., 2013; Hancocks, 2001; Pereira, Navarro & Martins, 2012). Raising public awareness of the need to conserve biological diversity is essential to safeguard the richness of life forms all over the world (Lindemann-Matthies, 2002). In this regard, institutions such as science museums, zoos and aquariums have the potential to play an important role (Rennie & Stocklmayer, 2003). Especially, zoos can provide a productive learning environment (Miles & Tout, 1992), facilitating the promotion of public conservation awareness and the adoption of pro-environmental behaviours that would reduce negative human impacts on biodiversity (Barongi, et al., 2015).
Based on these concepts, my study contributes to the developing field of visitor studies. Taking as reference non-zoo visitors and zoo visitors, I have focused on reviewing some aspects of conservation education, such as people's awareness of conservation, people's interest in animals and people's feelings towards animals and attitudes towards zoos. The study identified differences between non-regular and regular zoo visitors in interests in animals, as well as visitor attitudes towards conservation issues and zoos. Therefore, the present study indicated that positive emotional reactions and, in particular, a perceived sense of connection to the animal were linked and depended on the frequency of zoo visits. It was as well remarkable, that conservation awareness was influenced by the interest in animals, the interest in visiting zoos, the attitudes towards these institutions, and the age and the country of origin. All these variables had a greater effect in the conservation consciousness of the participants. Additionally interestingly, the main reason for visiting zoos in every country was to learn something about animals. This highlights the educational role of zoos and broadly supports the idea that people want to visit zoos to learn something about animals, in turn facilitating pro-conservation learning and changes in attitude. They are uniquely positioned to interact with visitors, communities, and society and to contribute by providing an informative and entertaining environment. Visiting zoos could led to contribute to promoting animal connectedness and interest in species.
This work presents, to our knowledge, the first completely passive imaging with human-body-emitted radiation in the lower THz frequency range using a broadband uncooled detector. The sensor consists of a Si CMOS field-effect transistor with an integrated log-spiral THz antenna. This THz sensor was measured to exhibit a rather flat responsivity over the 0.1–1.5-THz frequency range, with values of the optical responsivity and noise-equivalent power of around 40 mA/W and 42 pW/√Hz, respectively. These values are in good agreement with simulations which suggest an even broader flat responsivity range exceeding 2.0 THz. The successful imaging demonstratestheimpressivethermalsensitivitywhichcanbeachievedwithsuchasensor. Recording of a 2.3×7.5-cm2-sized image of the fingers of a hand with a pixel size of 1 mm2 at a scanning speed of 1 mm/s leads to a signal-to-noise ratio of 2 and a noise-equivalent temperature difference of 4.4 K. This approach shows a new sensing approach with field-effect transistors as THz detectors which are usually used for active THz detection.
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative movement disorder caused by expansion of CAG repeats in the ATXN2 gene beyond 33 units, while healthy individuals carry 22-23 repeats. First symptoms of SCA2 include uncoordinated movement, ataxic gait and slowing of the saccadic eye movements in line with the early pronounced atrophy of cerebellum, spinal cord and brainstem. Cerebellar Purkinje cells and spinal cord motor neurons are the most affected cells from ATXN2 expansions. Later on, patients manifest distal amyotrophy, problems in breathing and swallowing, depression and cognitive decline caused by widespread degeneration throughout the brain. The striking loss of mass in the brain, due to severe myelin fat atrophy, is accompanied by a similar reduction in the peripheral fat stores. After the devastating progression of disease, the severity and duration of which depends on the CAG repeat size, genetic background and environmental factors, patients succumb to SCA2 mostly because of respiratory failure at the terminal stage. Larger repeat sizes lead to an earlier manifestation of the disease and a more rapid progression. Aside from SCA2, intermediate-length and short pathogenic CAG expansions in ATXN2 between 26-39 repeats significantly increase the risk of developing other neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), fronto-temporal lobar dementia (FTLD) or Parkinson plus tauopathies like progressive supranuclear palsy (PSP) in various cohorts across the world.
Ataxin-2 (ATXN2) is a ubiquitously expressed cytosolic protein most famous for its involvement in neurodegenerative disease caused by the expanded poly-glutamine (polyQ) domain corresponding to a genomic (CAG)n tract. This N-terminal polyQ domain has no known function, other than increasing the aggregation propensity of mutant ATXN2 and facilitating interaction with other polyQ containing proteins, leading to their sequestration. The progressive accumulation of ATXN2 into cytosolic foci, and also that of its interaction partners over time, underlies the molecular pathomechanism. Next to polyQ domain, ATXN2 also contains a Like-Sm domain (Lsm), an Lsm-associated domain (LsmAD), multiple proline-rich domains (PRD) and a Poly(A)-Binding-Protein (PABP)-interacting motif (PAM2).
Through its Lsm/LsmAD domains, ATXN2 directly binds to a large number of transcripts, regulating their quality and translation rate. In a similar fashion, through its direct interaction with PABP via PAM2 motif, ATXN2 indirectly modifies the fate of even larger number of transcripts and global translation. Several PRDs scattered across the protein help ATXN2 associate with growth factor receptors and other endocytosis factors, modulating nutrient uptake and downstream signaling.
ATXN2 is a stress response factor. Therefore, its involvement in nutrient uptake plays a crucial part in cell’s capability to overcome non-permissive conditions. Upon nutrient deprivation, oxidative stress, proteotoxicity, heat stress or Ca2+ imbalance, ATXN2 relocalizes into cytosolic ribonucleoprotein particles known as stress granules (SGs), together with PABP, several eukaryotic translation initiation factors, many other RNA-binding proteins (RBP) with their target transcripts and the small ribosomal subunit. Collectively, they modulate the stability of the trapped transcripts, favoring the maturation and translation of IRES-dependent stress response proteins instead, according to the specific need. Many RBPs interact either directly or in an RNA-dependent manner in the SGs, and due to the large number of ALS-causing mutations identified in them (such as TDP-43, FUS, TIA-1, hnRNPA2/B1), SGs became a hot topic in neuropathology. Acute SGs serve to halt translation and growth, and to spend energy only for survival until stress disappears. However, chronic SG assembly eventually activates apoptotis leading to cell death. While the polyQ expansions in ATXN2 enhance SG stability, reduce their dissociation rate after stress, and lead to aberrant post-translational modifications of other SG components like TDP-43, complete loss of ATXN2 delays SG formation and results in easily dissolvable foci.
Most of the stressors that induce SG formation eventually converge on energetic deficit. Therefore, it is logical that the ultimate task of SGs is to stop further growth when it cannot be afforded. In yeast, the molecular mechanism underlying this growth arrest was explained as sequestration of the master growth regulator complex, Target-of-Rapamycin Complex 1 (TORC1), into SGs in an ATXN2-dependent manner. The repressor effect of ATXN2 on mammalian TORC1 (mTORC1) and global protein translation had already been documented in earlier studies; complete loss of ATXN2 function in knock-out mouse (Atxn2-KO) resulted in mTORC1 hyperactivity and transcriptional upregulation of multiple ribosomal subunits indicating an increased need for these machines. ...
A new phylogenetic hypothesis is proposed for the relationships among the species within the genus Docosia Winnertz, 1863, based on a combined analysis of five DNA markers (28S, ITS2, COI, COII and CytB). Five new species are described, Docosia anatolica Ševčík sp. nov. from Turkey, D. japonica Kurina sp. nov. from Japan, D. peloponnensis Ševčík sp. nov. from Greece, D. svanetica Kurina sp. nov. from Caucasus and D. polyspina Kurina sp. nov. from the Russian Far East. New country records of the following species are presented: D. diutina Plassmann, 1996 (Turkey), D. flavicoxa Strobl, 1900 (Georgia), D. gilvipes (Haliday in Walker, 1856) (Georgia), D. kerkini Kurina & Ševčík, 2011 (Bulgaria), D. moravica Landrock, 1916 (Georgia), D. pannonica Lastovka & Ševčík 2006 (Georgia) and D. rameli Kurina & Ševčík, 2011 (Slovakia).
We discuss the potential of light-nuclei measurements in heavy-ion collisions at intermediate energies for the search of the hypothetical QCD critical end-point. A previous proposal based on neutron density fluctuations has brought appealing experimental evidences of a maximum in the ratio of the number of tritons times protons, divided over deuterons square, O tpd. However these results are difficult to reconcile with the state-of-the-art statistical thermal model predictions. Based on the idea that the QCD critical point can lead to a substantial attraction among nucleons, we propose new light-nuclei multiplicity ratios involving He in which the maximum would be more noticeable. We argue that the experimental extraction is feasible by presenting these ratios formed from actual measurements of total and differential yields at low and high collision energies from FOPI and ALICE experiments, respectively. We also illustrate the possible behavior of these ratios at intermediate energies applying a semiclassical method based on flucton paths using the preliminary NA49 and STAR data for O tpd as input.
This collection of articles is based on presentations and discussions at the 2018 African Potentials Forum, held in Accra, Ghana. This forum was a part of the African Potentials Project, which aims to clarify the latent problem-solving abilities, ways of thinking, and institutions that have been created, accumulated, unified, and deployed in the everyday experiences of Africans. The notion of Africas latent power/potential is not related to romanticisation of the traditional knowledge of African society and its institutions as fixed, essentialised magic wands. This notion also raises objections against political dogmas that seek to smoke out and eliminate thought and values originating in Western modernity. The keyword of the Accra Forum was futurity. Africas future is laden with possibilities, latent power, and potential. It is bright and hopeful but, simultaneously, bleak and thought-provoking. For nascent democracies and economically challenged communities, the value of this potential lies not in its static qualities but in how these qualities can be harnessed and translated into beneficial practical outcomes. As a concept, potential connotes a time to come; a futurity that is full of known and unknown possibilities, challenges, and opportunities.
Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.
Placing security studies in the context of contemporary discourses about the colonial comeback and posthumanism, this book postulates the notion of staticide which avers that the effacement of African state sovereignty is crucial for the security of the oncoming empire. Understood in the light of posthumanism, antihumanism, animism, postanthropocentrism and transhumanism; African human security has evidently been put on a recession course together with African state security. Much as African states are demonised as so failed, defective, corrupt, weak and rogue to require recolonisation; transhumanism also assumes that human bodies are so corrupt, imperfect, defective, failed, rogue and weak to require not only enhancements or augmentation but also to beckon recolonisation. Also, deemed to be ecologies, human bodies are set to be liberalised and democratised in the interest of nonhuman viruses, nanobots, microchips, bacteria, fungi and other pathogens living within the bodies. The book critically examines the security implications of theorising human bodies as ecologies for nonhuman entities. Reading staticide together with transhumanism, this book foresees transhumanist new eugenics that are accompanying the new empire in a supposedly Anthropocene world that serves to justify the sacrifice and disposability of some surplus humans living in the recesses and nether regions of the empire. Paying attention to the colonial comeback, the book urges African scholars not to mistake imperial transformation for decolonisation. The book is invaluable for scholars and activists in African studies, anthropology, decoloniality, sociology, politics, development studies, security studies, sociology and anthropology of science and technology studies, and environmental studies.
Reflections of South African Student Leaders 1994-2017 brings together the reflections of twelve former SRC leaders from across the landscape of South African universities. Reviews of the previous volume, 1981-2014 suggested that it contributed significantly to a better understanding of the stringent demands of visionary and transformative leadership required by university leaders in the fastchanging and increasingly complex public higher education sector. This volume is based on comprehensive interviews with former student leaders, each of whom provided a personal account in their own words of their experience in the position of student leadership. The interviewees are from different backgrounds and of diverse political persuasions. The book is important for current and future leaders of higher education institutions as it provides insights into the thinking, aspirations, desires, fears and modus operandi of student leaders. Such insight can contribute to developing and implementing appropriate strategies for achieving meaningful and constructive engagement with current and future student leaders.
Dialogues in climate and environmental research, policy and planning : a special focus on Zimbabwe
(2020)
Climate change is the topic of the century. It is a subject of discussion by sceptics, heretics and those that have immersed in it as a serious debate for engagement. In this volume, the matter is localised to the plateau bordered by the great rivers of Limpopo to the south and Zambezi to the north. Evidence has it that climate change is inducing immense environmental change hitherto unknown including water stress and droughts, heat waves and flooding. The effects span across all sectors agriculture, forestry, engineering, construction and other socio-economic dimensions of life. When an issue becomes such topical, it becomes political but also courts policy debate. The thrust of this volume is to explore into climate change as an environmental concern begging government attention and requiring prioritisation as a shaper of our future, whether we set to put mitigation or adaptation measures in place, or we choose to do nothing about it, as sceptics would perhaps suggest. The book explores climate change as a theoretical, policy, technical and practical debate as it affects sectors and rural and urban spatialities in Zimbabwe. Contributions explore such themes as regional research, gender, disaster preparedness, policymaking, resilience, governance, urban planning, risk management, environmental law, and the food-water-health-energy-climate change nexus.
Positing the notions of coloniality of ignorance and geopolitics of ignorance as central to coloniality and colonisation, this book examines how colonialists socially produced ignorance among colonised indigenous peoples so as to render them docile and manageable. Dismissing colonial descriptions of indigenous people as savages, illiterate, irrational, prelogical, mystical, primitive, barbaric and backward, the book argues that imperialists/colonialists contrived geopolitics of ignorance wherein indigenous regions were forced to become ignorant, hence containable and manageable in the imperial world. Questioning the provenance of modernist epistemologies, the book asks why Eurocentric scholars only contest the provenance of indigenous knowledges, artefacts and scientific collections. Interrogating why empire sponsors the decolonisation of universities/epistemologies in indigenous territories while resisting the repatriation/restitution of indigenous artefacts, the book also wonders why Westerners who still retain indigenous artefacts, skulls and skeletons in their museums, universities and private collections do not consider such artefacts and skulls to be colonising them as well. The book is valuable to scholars and activists in the fields of anthropology, museums and heritage studies, science and technology studies, decoloniality, policymaking, education, politics, sociology and development studies.
This volume brings together seven empirically grounded contributions by African social scientists of different disciplinary backgrounds. The authors explore the social impact of religious innovation and competition in present day Africa. They represent a selection from an interdisciplinary initiative that made 23 research grants for theologians and social scientists to study Christianity and social change in contemporary Africa. These contributions focus on a variety of dynamics in contemporary African religion (mostly Christianity), including gender, health and healing, social media, entrepreneurship, and inter-religious borrowing and accommodation. The volume seeks to enhance understanding of religion's vital presence and power in contemporary Africa. It reveals problems as well as possibilities, notably some ethical concerns and psychological maladies that arise in some of these new movements, notably neo-Pentecostal and militant fundamentalist groups. Yet the contributions do not fixate on African problems and victimization. Instead, they explore sources of African creativity, resiliency and agency. The book calls on scholars of religion and religiosity in Africa to invest new conceptual and methodological energy in understanding what it means to be actively religious in Africa today.
Covid stories from East Africa and beyond : lived experiences and forward-looking reflections
(2020)
The coronavirus has rattled humanity, tested resolve and determination, and redefined normalcy. This compelling collection of 29 short stories and essays brings together the lived experiences of covid19 through a diversity of voices from across the African continent. The stories highlight challenges, new opportunities, and ultimately the deep resilience of Africans and their communities. Bringing into conversation the perspectives of laypeople, academics, professionals, domestic workers, youth, and children, the volume is a window into the myriad ways in which people have confronted, adapted to, and sought to tackle the coronavirus and its trail of problems. The experiences of the most vulnerable are specifically explored, and systemic changes and preliminary shifts towards a new global order are addressed. Laughter as a coping mechanism is a thread throughout.
The inability to eradicate poverty among societies demands a synergistic approach. This calls for the development of multi-pronged pathways for transitioning towards sustainable development goals. Many of these have been developed and tested across the world. Some have proved to be effective in illuminating the underlying cause of the world's inability to eradicate poverty. This is being driven by the fact that sustainable development, as a global development concept, represents a multidimensional phenomenon that includes many different indicators of human development. This volume, which derives from the papers presented at the seventh Africa Unity for Renaissance Conference that was held at Freedom Park, Pretoria, South Africa, seeks to supplement existing pathways by highlighting Africa's approach to poverty alleviation, which can possibly be attained through enhanced nutrition, food security, energy and gender equity. Evidence presented reflects strengths, weaknesses and opportunities on how Africa can transition towards sustainable development goals. The information provided is useful to countries interested in assisting Africa to develop pathways for achieving sustainable development goals within the scope of Agenda 2063. The book is a good reference for policy makers, academics, government authorities and students interested in research and developmental studies.
Einen Überblick über neueste Forschungsergebnisse der Wissenschaftler am IMFS, Berichte von Konferenzen und Vorträgen sowie ausführliche Informationen zum derzeit größten Forschungsprojekt Macroeconomic Modeling and Comparison Initiative (MMCI) bietet der IMFS-Jahresbericht 2019, der jetzt veröffentlicht ist. Darüber hinaus gibt IMFS-Professor Michael Haliassos im Interview einen Einblick in seine Arbeit zum Finanzverhalten der privaten Haushalte und die ehemaligen Mitarbeiter Philipp Lieberknecht und Felix Strobel berichten, wie sie im Berufsleben auf ihrer Forschung am IMFS aufbauen können.
Auf rund 100 Seiten zeigt der Bericht die Highlights des Jahres, alle Mitarbeiter sowie die Projekte, Publikationen sowie die Veranstaltungen des IMFS, darunter „The ECB and Its Watchers“ zu finden. Der Jahresbericht ist auf Englisch erschienen und steht im PDF-Format zur Verfügung.