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Let's call it Nachbarschaft
(2024)
Im Sommer 2023 zogen das ZfL, das ZAS und die gemeinsame Verwaltung der Geisteswissenschaftlichen Zentren Berlin aus der Schützenstraße in Berlin-Mitte nach Wilmersdorf. In dem an der Pariser Str. 1, Ecke Meierottostr. 8 neu errichteten Gebäude ACHTUNDEINS von Eike Becker_Architekten bespielen die Zentren nun insgesamt drei Etagen. Im Erdgeschoss befinden sich, von außen einsehbar, die Forschungsbibliotheken von ZfL und ZAS sowie der Eberhard-Lämmert-Saal. Während des Neujahrsempfangs, mit dem sich ZfL, ZAS und die GWZ am 11. Januar 2024 der unmittelbaren Nachbarschaft vorstellten, entstand die Idee zu dieser Glosse.
In a similar way to dramatic performances and plays, song lyrics establish a complex discourse structure whereby listeners are placed in a position to overhear ‘the pretence of a conversation constructed to convey the performer’s meaning’ (Nahajec 2019: 25; see also Short 1996: 169). In Taylor Swift’s songwriting, listeners are positioned not only to eavesdrop on the narratives presented but are also invited to conceptualise and enact particular roles and scenarios in the discourse. This paper offers a stylistic analysis of songwriting and narrative structure across Swift’s oeuvre to identify how disnarration strategies are used to build stories in her two sister albums written and produced during the Covid-19 pandemic, folklore (2020) and evermore (2020). Specifically, this study examines how disnarration characterises the albums’ narrators, establishes narrator-narratee relationships and invites listeners to adopt a participatory role in the meaning-making process. Through close analysis of four songs across the two albums, this paper builds on developing studies of the stylistics of songwriting (see West 2019) and argues that disnarration strategies foreground particular themes within the discourse, such as nostalgia, wistfulness and regret, and contribute to the fictionalisation and self-aware storytelling characteristic of these albums’ storyworlds.
The Federal Reserve has been publishing federal funds rate prescriptions from Taylor rules in its Monetary Policy Report since 2017. The signals from the rules aligned with Fed action on many occasions, but in some cases the Fed opted for a different route. This paper reviews the implications of the rules during the coronavirus pandemic and the subsequent inflation surge and derives projections for the future.
In 2020, the Fed took the negative prescribed rates, which were far below the effective lower bound on the nominal interest rate, as support for extensive and long-lasting quantitative easing. Yet, the calculations overstate the extent of the constraint, because they neglect the supply side effects of the pandemic.
The paper proposes a simple model-based adjustment to the resource gap used by the rules for 2020. In 2021, the rules clearly signaled the need for tightening because of the rise of inflation, yet the Fed waited until spring 2022 to raise the federal funds rate. With the decline of inflation over the course of 2023, the rules’ prescriptions have also come down. They fall below the actual federal funds rate target range in 2024. Several caveats concerning the projections of the interest rate prescriptions are discussed.
Although iron-based catalysts are regarded as a promising alternative to precious metal catalysts, their precise electronic structures during catalysis still pose challenges for computational descriptions. A particularly urgent question is the influence of the environment on the electronic structure, and how to describe this properly with computational methods. Here, we study an iron porphyrin chloride complex adsorbed on a graphene sheet using density functional theory calculations to detail how much the electronic structure is influenced by the presence of a graphene layer. Our results indicate that weak interactions due to van der Waals forces dominate between the porphyrin complex and graphene, and only a small amount of charge is transferred between the two entities. Furthermore, the interplay of the ligand field environment, strong p − d hybridization, and correlation effects within the complex are strongly involved in determining the spin state of the iron ion. By bridging molecular chemistry and solid state physics, this study provides first steps towards a joint analysis of the properties of iron-based catalysts from first principles.
Determining the structure and mechanisms of all individual functional modules of cells at high molecular detail has often been seen as equal to understanding how cells work. Recent technical advances have led to a flush of high-resolution structures of various macromolecular machines, but despite this wealth of detailed information, our understanding of cellular function remains incomplete. Here, we discuss present-day limitations of structural biology and highlight novel technologies that may enable us to analyze molecular functions directly inside cells. We predict that the progression toward structural cell biology will involve a shift toward conceptualizing a 4D virtual reality of cells using digital twins. These will capture cellular segments in a highly enriched molecular detail, include dynamic changes, and facilitate simulations of molecular processes, leading to novel and experimentally testable predictions. Transferring biological questions into algorithms that learn from the existing wealth of data and explore novel solutions may ultimately unveil how cells work.
Highlights
• Currently, China has the most publications, ahead of the USA and European countries.
• Research focuses are strictly separated into ecological and material science topics.
• Russia and Ukraine are among the frontrunners with a clear focus on materials science.
• The focus in PFAS research is shifting toward ecological issues.
• A national imbalance can be observed that leaves the low economies behind.
Abstract
The European Commission's current efforts to launch the largest proposal to restrict per- and polyfluoroalkyl substances (PFAS) in history reflect the dire global plight of PFAS accumulation in the environment and their health impacts. While there are existing studies on PFAS research, there is a lack of comprehensive analysis that both covers the entire research period and provides deep insights into global research patterns, incentives, and barriers based on various parameters. We have been able to demonstrate the increasing interest in PFAS research, although citation numbers are declining prematurely. Policy regulations based on proving and establishing the toxicity of PFASs have stimulated research in developed countries and vice versa, with increasing emphasis on ecological aspects. China, in particular, is investing increasingly in PFAS research, but without defining or implementing regulations - with devastating effects. The separation of industrial and environmental research interests is clear, with little involvement of developing countries, even though their exposure to PFAS is devastating. It, therefore, requires increased globally networked and multidisciplinary approaches to address PFAS contamination challenges.
Motivated by the question of the impact of selective advantage in populations with skewed reproduction mechanisms, we study a Moran model with selection. We assume that there are two types of individuals, where the reproductive success of one type is larger than the other. The higher reproductive success may stem from either more frequent reproduction, or from larger numbers of offspring, and is encoded in a measure Λ for each of the two types. Λ-reproduction here means that a whole fraction of the population is replaced at a reproductive event. Our approach consists of constructing a Λ-asymmetric Moran model in which individuals of the two populations compete, rather than considering a Moran model for each population. Provided the measure are ordered stochastically, we can couple them. This allows us to construct the central object of this paper, the Λ−asymmetric ancestral selection graph, leading to a pathwise duality of the forward in time Λ-asymmetric Moran model with its ancestral process. We apply the ancestral selection graph in order to obtain scaling limits of the forward and backward processes, and note that the frequency process converges to the solution of an SDE with discontinuous paths. Finally, we derive a Griffiths representation for the generator of the SDE and use it to find a semi-explicit formula for the probability of fixation of the less beneficial of the two types.
IHMCIF: an extension of the PDBx/mmCIF data standard for integrative structure determination methods
(2024)
IHMCIF (github.com/ihmwg/IHMCIF) is a data information framework that supports archiving and disseminating macromolecular structures determined by integrative or hybrid modeling (IHM), and making them Findable, Accessible, Interoperable, and Reusable (FAIR). IHMCIF is an extension of the Protein Data Bank Exchange/macromolecular Crystallographic Information Framework (PDBx/mmCIF) that serves as the framework for the Protein Data Bank (PDB) to archive experimentally determined atomic structures of biological macromolecules and their complexes with one another and small molecule ligands (e.g., enzyme cofactors and drugs). IHMCIF serves as the foundational data standard for the PDB-Dev prototype system, developed for archiving and disseminating integrative structures. It utilizes a flexible data representation to describe integrative structures that span multiple spatiotemporal scales and structural states with definitions for restraints from a variety of experimental methods contributing to integrative structural biology. The IHMCIF extension was created with the benefit of considerable community input and recommendations gathered by the Worldwide Protein Data Bank (wwPDB) Task Force for Integrative or Hybrid Methods (wwpdb.org/task/hybrid). Herein, we describe the development of IHMCIF to support evolving methodologies and ongoing advancements in integrative structural biology. Ultimately, IHMCIF will facilitate the unification of PDB-Dev data and tools with the PDB archive so that integrative structures can be archived and disseminated through PDB.
The economic rise of China has changed the global economy. The authors explore China’s transformation from a low-cost manufacturing hub to an increasingly innovation- and service-driven economy. Major growth drivers for the period 2010-2025 are analysed, including the paradigms of “Made in China” and the “Dual Circulation Strategy”. The export intensity of China’s economy is declining overall, with a tendency towards greater regional diversification and a gradual decoupling from North America and the European Union. At the same time, trade and investment activities are increasingly geared to the Belt and Road Initiative. Furthermore, labour and energy cost advantages for manufacturing operations in China are likely to diminish in the coming years, calling into question China’s attractiveness as a global manufacturing hub. In this regard, the further development of regional and industrial clusters is pivotal for China to enhance its global competitiveness and remain an attractive destination for foreign direct investment (FDI) in the medium term. On the other hand, high productivity in science and technology and rich deposits of critical minerals put China in a favourable position in advanced industries. Important challenges include the still wide development gap between rural and urban areas, the structural mismatch in the labour market, with persistently high youth unemployment, and the race to achieve carbon neutrality by 2060.
Research around the “glass escalator” demonstrates that men receive promotions faster than women in women-dominated occupations. However, it remains unclear how overall establishment composition affects the glass escalator. We use German longitudinal linked employer-employee data (LIAB) between 2012 and 2019 to examine how occupational and establishment gender composition shape gender differences in promotions to management. Establishment gender composition moderates the glass escalator, meaning women's mobility disadvantages in women-dominated jobs are most pronounced in men-dominated establishments. We hypothesize that changing occupational status is a central mechanism: When occupations mirror the composition of the establishment, their status increases locally. Higher occupational status offsets lower leadership expectations attributed to women and increases women's promotion odds relative to their male colleagues.
The Russian invasion of Ukraine illustrates the increasingly judicialized nature of international relations and geopolitics. By viewing aspects of the invasion as illegal – in particular through the identification of war crimes and crimes against humanity – the international response draws attention to the political geographies of international criminal investigation. Human rights groups, academics, journalists, and open-source forensic investigations have joined forces to collect, evaluate and analyze the violent nature of war crimes. While similar shifts in evidence gathering have been observed in the case of the Bosnia-Herzegovina war and the Assad regime's violence against Syrian citizens, the use of evidence-gathering technologies and evidence-securing institutions in the case of Ukraine is distinctive. In this scholarly intervention we seek to illustrate the intimate geopolitics of evidence gathering by zooming in on two different elements that shape evidential procedures in Ukraine: i) the blurring of civilian/military boundaries; and ii) the challenges of access. By evaluating what is new and what is similar to previous war sites, we suggest that these two areas reflect a geopolitics of evidence gathering, highlighting its global-local intimacies. Both these areas are well positioned to foster new research on the (geo)legal nature of war crimes in political geography and beyond.
Studying the neural basis of human dynamic visual perception requires extensive experimental data to evaluate the large swathes of functionally diverse brain neural networks driven by perceiving visual events. Here, we introduce the BOLD Moments Dataset (BMD), a repository of whole-brain fMRI responses to over 1,000 short (3s) naturalistic video clips of visual events across ten human subjects. We use the videos’ extensive metadata to show how the brain represents word- and sentence-level descriptions of visual events and identify correlates of video memorability scores extending into the parietal cortex. Furthermore, we reveal a match in hierarchical processing between cortical regions of interest and video-computable deep neural networks, and we showcase that BMD successfully captures temporal dynamics of visual events at second resolution. With its rich metadata, BMD offers new perspectives and accelerates research on the human brain basis of visual event perception.
The ubiquitin (Ub) code denotes the complex Ub architectures, including Ub chains of different length, linkage-type and linkage combinations, which enable ubiquitination to control a wide range of protein fates. Although many linkage-specific interactors have been described, how interactors are able to decode more complex architectures is not fully understood. We conducted a Ub interactor screen, in humans and yeast, using Ub chains of varying length, as well as, homotypic and heterotypic branched chains of the two most abundant linkage types – K48- and K63-linked Ub. We identified some of the first K48/K63 branch-specific Ub interactors, including histone ADP-ribosyltransferase PARP10/ARTD10, E3 ligase UBR4 and huntingtin-interacting protein HIP1. Furthermore, we revealed the importance of chain length by identifying interactors with a preference for Ub3 over Ub2 chains, including Ub-directed endoprotease DDI2, autophagy receptor CCDC50 and p97-adaptor FAF1. Crucially, we compared datasets collected using two common DUB inhibitors – Chloroacetamide and N-ethylmaleimide. This revealed inhibitor-dependent interactors, highlighting the importance of inhibitor consideration during pulldown studies. This dataset is a key resource for understanding how the Ub code is read.
Zinc finger (ZnF) domains appear in a pool of structural contexts and despite their small size achieve varying target specificities, covering single-stranded and double-stranded DNA and RNA as well as proteins. Combined with other RNA-binding domains, ZnFs enhance affinity and specificity of RNA-binding proteins (RBPs). The ZnF-containing immunoregulatory RBP Roquin initiates mRNA decay, thereby controlling the adaptive immune system. Its unique ROQ domain shape-specifically recognizes stem-looped cis-elements in mRNA 3’-untranslated regions (UTR). The N-terminus of Roquin contains a RING domain for protein-protein interactions and a ZnF, which was suggested to play an essential role in RNA decay by Roquin. The ZnF domain boundaries, its RNA motif preference and its interplay with the ROQ domain have remained elusive, also driven by the lack of high-resolution data of the challenging protein. We provide the solution structure of the Roquin-1 ZnF and use an RBNS-NMR pipeline to show that the ZnF recognizes AU-rich elements (ARE). We systematically refine the contributions of adenines in a poly(U)-background to specific complex formation. With the simultaneous binding of ROQ and ZnF to a natural target transcript of Roquin, our study for the first time suggests how Roquin integrates RNA shape and sequence specificity through the ROQ-ZnF tandem.
G protein-coupled receptors (GPCRs) play a crucial role in modulating physiological responses and serve as the main drug target. Specifically, salmeterol and salbutamol which are used for the treatment of pulmonary diseases, exert their effects by activating the GPCR β2-adrenergic receptor (β2AR). In our study, we employed coarse-grained molecular dynamics simulations with the Martini 3 force field to investigate the dynamics of drug molecules in membranes in presence and absence of β2AR. Our simulations reveal that in more than 50% of the flip-flop events the drug molecules use the β2AR surface to permeate the membrane. The pathway along the GPCR surface is significantly more energetically favorable for the drug molecules, which was revealed by umbrella sampling simulations along spontaneous flip-flop pathways. Furthermore, we assessed the behavior of drugs with intracellular targets, such as kinase inhibitors, whose therapeutic efficacy could benefit from this observation. In summary, our results show that β2AR surface interactions can significantly enhance membrane permeation of drugs, emphasizing their potential for consideration in future drug development strategies.
Motivated by the question of the impact of selective advantage in populations with skewed reproduction mechanims, we study a Moran model with selection. We assume that there are two types of individuals, where the reproductive success of one type is larger than the other. The higher reproductive success may stem from either more frequent reproduction, or from larger numbers of offspring, and is encoded in a measure Λ for each of the two types. Our approach consists of constructing a Λ-asymmetric Moran model in which individuals of the two populations compete, rather than considering a Moran model for each population. Under certain conditions, that we call the "partial order of adaptation", we can couple these measures. This allows us to construct the central object of this paper, the Λ−asymmetric ancestral selection graph, leading to a pathwise duality of the forward in time Λ-asymmetric Moran model with its ancestral process. Interestingly, the construction also provides a connection to the theory of optimal transport. We apply the ancestral selection graph in order to obtain scaling limits of the forward and backward processes, and note that the frequency process converges to the solution of an SDE with discontinous paths. Finally, we derive a Griffiths representation for the generator of the SDE and use it to find a semi-explicit formula for the probability of fixation of the less beneficial of the two types.
The chenopodium aphid, Hayhurstia atriplicis (Linnaeus, 1761) (Hemiptera: Aphididae), is reported for the first time in Colombia. The aphid was found on the aerial parts of the quinoa plant, Chenopodium quinoa Willd. (Amaranthaceae), especially on the leaves, in five municipalities in the department of Cauca, Colombia. Brief information on its natural enemies, distribution and biology is provided. This is the only aphid in Colombia known to cause malformations on the leaves of quinoa plants. In South America, this aphid has been found previously only in Ecuador, where it was reported for the first time in 2023 based on specimens collected from 2019 to 2021. However, we report that H. atriplicis was likely introduced to Ecuador in the 2000s or earlier, based on a collection dated 2006 found in the United States National Museum of Natural History.
ZooBank registration. urn:lsid:zoobank.org:pub:F43613E0-2854-44DE-9654-74138909717D
First record of the beekeeping pest Aethina tumida Murray (Coleoptera: Nitidulidae) for Honduras
(2024)
Aethina tumida Murray (Coleoptera: Nitidulidae) (also known as the small hive beetle), an important pest in apiaries, is reported from Honduras for the first time, new country record. The precise distribution in the country is unknown, and no damage related to it has been observed. Photographs are provided to aid in its identification. Differentiation of A. tumida from Aethina villosa Reitter and Aethina quadrata Sharp, which also occur in Honduras, is provided.
ZooBank registration. urn:lsid:zoobank.org:pub:DAF12C6A-0F8C-4151-9C4D-F191CCC4032F
Three species of false click beetles (Coleoptera: Eucnemidae) are added to the Nearctic fauna. One new species, Isorhipis bicolor, is described from a small series collected in Florida, U.S.A. Eighteen specimens collected from Georgia were identified as Dyscharachthis amplicollis (Fleutiaux), new U.S.A. records for a species previously taken from Japan and Southeast Asia. Examination of a series of eucnemids collected by Kyle Schnepp in Florida allowed me to revisit the Deltometopus fauna in eastern North America. Antennal structures present in a series of male specimens in the loan and past examined specimens are definitive enough to resurrect Deltometopus ereptus Bonvouloir, status restored, from synonymy with Deltometopus amoenicornis (Say). Species identification keys are provided for Deltometopus Bonvouloir and Isorhipis Boisduval and Lacordaire in the Nearctic region. Diagnostic differences are briefly noted for each of the three newly added species found in the United States. Images of three species and the related D. amoenicornis are provided.
ZooBank registration. urn:lsid:zoobank.org:pub:30F462F1-966F-4A4F-9D10-BF967AED6574
In der Bibliographie sind alle bisher ermittelten Publikationen von und über Curt SigmarGutkind verzeichnet. Belegexemplare der von ihm verfassten Aufsätze und Zeitungsbeiträge(Rezensionen, Theaterkritiken usw.) befinden sich in seinem im Mannheimer Stadtarchivaufbewahrten Nachlass. Alle Einträge wurden autoptisch geprüft.
Dorothea Gotfurt, 1907–1995
(2024)
Dorothea Gotfurt kam 1935 als Exilantin nach England. Dort wurde sie zur Übersetzerin. Zwischen 1955 und 1970 veröffentlichte sie vor allem im Scherz-Verlag (Bern), aber auch bei Fischer (Frankfurt/M.), Rowohlt (Reinbek) oder Szolnay (Wien) über dreißig von ihr ins Deutsche gebrachte Romane aus der zeitgenössischen englischsprachigen Literatur.
Im November durfte er seinen 77. Geburtstag feiern, von Ruhestand ist aber noch keine Spur. Gerade bereitet er sich in seinem Büro über der Neuen Mensa am alten Campus in Bockenheim mit großem Elan auf die nächste Seminarsitzung vor. »Die Lehre an der Universität wie an Fachhochschulen war mir nie eine Last. Ich habe versucht, die Studierenden zu motivieren oder bei Bedarf gar zu provozieren, um zu kommunizieren, weil wir alle viel mehr von gegenseitigem Austausch haben«, sagt Ludwig Salgo. Zahlreiche Studierende der Sozialen Arbeit, aus der Rechtswissenschaft, aber auch aus der Erziehungswissenschaft haben seine Veranstaltungen besucht; etliche Juristinnen und Juristen haben bei ihm promoviert, sich für die pädagogische oder juristische Laufbahn qualifiziert. Sein zentrales Thema in Forschung und Lehre: das Verhältnis Eltern-Kind-Staat. Anfang 2012 ging er in den Ruhestand, doch die Lehre blieb vorerst seine große Passion. Jetzt beendet er seine Seniorprofessur an der Goethe-Universität zum Semesterende nach zehn Jahren: »Nun ist es genug«, sagt er. In der Fortbildung für Jugendämter, Verfahrensbeistände und Juristen, auch in Stiftungen und Verbänden, hier vor allem im Kinderschutzbund in Frankfurt, möchte er weiterhin aktiv bleiben, auch um für das Thema Kindeswohl zu sensibilisieren. Dass er dann mehr Zeit für seine große Leidenschaft haben wird, freut ihn: »Ich leide an der Melomanie«, sagt der passionierte Freund klassischer Musik. »Wie Nietzsche treffenderweise einmal bemerkt hat, wäre das Leben ohne Musik ein Irrtum.«
Unter Experten in Sachen Übersetzungsgeschichte ist Johann Diederich Gries kein Unbekannter. Er zählt z. B. zu den zehn "bedeutende[n] Übersetzerpersönlichkeiten von der frühen Neuzeit bis heute", deren Leben und Werk in der Europäischen Übersetzungsgeschichte von Jörn Albrecht und Iris Plack dargestellt wird. Friedmar Apels von Gottsched und Bode bis Dedecius und Enzensberger reichende "Leseliste zur Geschichte des Übersetzens in Deutschland" umfasst 60 Übersetzer, von Gries werden dessen Calderón- und Tasso-Übersetzungen zur Lektüre empfohlen.
We describe a new species of karst-dwelling pitviper from Chumphon Province of Peninsular Thailand, in the Isthmus of Kra, based on morphological and molecular data (2427 bp from cyt b, ND4 and 16S rRNA mitochondrial DNA genes). Morphologically, Trimeresurus kraensis sp. nov. is distinguished from other congeners by the following combination of morphological characters: a dark/bottle-green dorsum with reddish-brown or purple crossbands; pale green venter lacking dark dots; stripes present on the lateral sides of the ventrals; internasals generally in contact; one large supraocular scale on each side of the head; iris pale copper; tail brown with dark purplish-brown crossbars; dorsal scales in 21–21–15 rows; ventral scales 167 in a single male, 169–171 in females; subcaudal scales 62 in a single male, 52–54 in females, all paired. White vertebral spots present in males, located on approximately every two or four dorsal scales; dark brown spots forming discontinuous pattern present on 1–3 lateral dorsal scale rows; males with reddish-brown postocular stripe with jagged edges. The new species differs from the morphologically similar species Trimeresurus venustus s. str. by a notable divergence in cytochrome b mitochondrial DNA gene sequences (p = 5.9%).
In the vast abyssal plains northwest of Iceland, white glass sponges of the genus Caulophacus Schulze, 1886 were inhabited by reddish Bythocaris G.O. Sars, 1870 shrimps and pinkish amphipods. After in situ observations at 3700 m depth, in -1°C waters by a remotely operated vehicle, members of this assemblage were collected and preserved for molecular studies. Based on integrative taxonomic analyses, the amphipods were identified as a new species of the genus Halirages Boeck, 1871 – Halirages spongiae sp. nov. Lörz, Nack & Tandberg –, as described in detail below. Part of our integrative approach was to establish reference DNA barcodes for known species of Halirages. However, our investigation of material of Calliopiidae G.O. Sars, 1895 collected around Iceland and Norway revealed slight morphological discrepancies in all the described species of Halirages. Except for Halirages fulvocinctus (M. Sars, 1858), none of the encountered specimens of Calliopiidae fully matched a current species description. We illuminate the morphological characteristics of nine operational taxonomic units, which also represented clades in COI and 28S. We set the Icelandic samples in the context of Halirages from Canada and Norway. A key to the world species of Halirages is provided.
Highlights
• Seed size mediates seedling recruitment in tropical forests and pastures.
• Large-seeded species recruited better than small-seeded species in the forest.
• Recruitment of large-seeded species in pastures was limited by surface temperature.
• Large-seeded species should be protected against drought in regenerating pastures.
Abstract
Seedling recruitment is a key process of plant regeneration that often depends on plant functional traits, such as seed size. To optimize forest restoration efforts, we need to better understand how seedling recruitment of different seed sizes varies along environmental gradients with strong variation in abiotic and biotic factors. To understand these interacting effects, we conducted a sowing experiment with different-sized seeds in forests and pastures in the tropical mountains of southern Ecuador. We quantified seedling recruitment in relation to temperature, soil moisture and biotic pressures. We sowed seeds of five tree species of varying seed size at three elevations (1000, 2000 and 3000 m a.s.l.) in primary forest and pastures. We tested (1) how habitat type influences the recruitment of seedlings belonging to three small- and two large-seeded species, and (2) how abiotic and biotic factors limit seedling recruitment of species with different seed sizes. We found that seedlings of the two large-seeded species recruited better than seedlings of the three small-seeded species, but only in the forest habitat. Seedling recruitment of large seeds was primarily limited by high surface temperature, which explains lower recruitment of large seeds in pastures compared to forests. Our study shows that seed size can be a key trait mediating variability in seedling recruitment in tropical ecosystems. We conclude that restoration measures should aim to mitigate extreme temperatures in tropical pastures to aid the natural regeneration of large-seeded tree species.
Highlights
• Six Newton methods for solving matrix quadratic equations in linear DSGE models.
• Compared to QZ using 99 different DSGE models including Smets and Wouters (2007).
• Newton methods more accurate than QZ with comparable computation burden.
• Apt for refining solutions from alternative methods or nearby parameterizations.
Abstract
This paper presents and compares Newton-based methods from the applied mathematics literature for solving the matrix quadratic that underlies the recursive solution of linear DSGE models. The methods are compared using nearly 100 different models from the Macroeconomic Model Data Base (MMB) and different parameterizations of the monetary policy rule in the medium-scale New Keynesian model of Smets and Wouters (2007) iteratively. We find that Newton-based methods compare favorably in solving DSGE models, providing higher accuracy as measured by the forward error of the solution at a comparable computation burden. The methods, however, suffer from their inability to guarantee convergence to a particular, e.g. unique stable, solution, but their iterative procedures lend themselves to refining solutions either from different methods or parameterizations.
The hierarchical feature regression (HFR) is a novel graph-based regularized regression estimator, which mobilizes insights from the domains of machine learning and graph theory to estimate robust parameters for a linear regression. The estimator constructs a supervised feature graph that decomposes parameters along its edges, adjusting first for common variation and successively incorporating idiosyncratic patterns into the fitting process. The graph structure has the effect of shrinking parameters towards group targets, where the extent of shrinkage is governed by a hyperparameter, and group compositions as well as shrinkage targets are determined endogenously. The method offers rich resources for the visual exploration of the latent effect structure in the data, and demonstrates good predictive accuracy and versatility when compared to a panel of commonly used regularization techniques across a range of empirical and simulated regression tasks.
ISOE-Newsletter Nr. 2/2024
(2024)
Wissenschaftskommunikation zu Risiken von Ewigkeitschemikalien +++ Gemeinsam statt gegeneinander: Waldkonflikte konstruktiv lösen +++ Künstlerische Forschung: Projektstipendium „Insectopolis“ vergeben +++ Sommersemester 2024: Soziale Ökologie und Transdisziplinarität in der Lehre +++ Ökologische Kipppunkte in der mongolischen Steppe erkennen und vermeiden +++ Aktuelle Beiträge im ISOE Blog +++ Aus dem ISOE +++ Das ISOE in den Medien +++ Termine +++ Publikationen
A considerable effort has been dedicated recently to the construction of generic equations of state (EOSs) for matter in neutron stars. The advantage of these approaches is that they can provide model-independent information on the interior structure and global properties of neutron stars. Making use of more than 106 generic EOSs, we assess the validity of quasi-universal relations of neutron-star properties for a broad range of rotation rates, from slow rotation up to the mass-shedding limit. In this way, we are able to determine with unprecedented accuracy the quasi-universal maximum-mass ratio between rotating and nonrotating stars and reveal the existence of a new relation for the surface oblateness, i.e., the ratio between the polar and equatorial proper radii. We discuss the impact that our findings have on the imminent detection of new binary neutron-star mergers and how they can be used to set new and more stringent limits on the maximum mass of nonrotating neutron stars, as well as to improve the modeling of the X-ray emission from the surface of rotating stars.
SAFE Update April 2024
(2024)
Highligthts
• Marburg virus infects and replicates in primary human proximal tubular cells (PTC).
• Transcriptome analyses at multiple time points revealed a profound inflammatory response by IFNα, -y and TNFα signaling.
• Among the strongly downregulated gene sets were targets of the transcription factors MYC and E2F, the G2M checkpoint, as well as oxidative phosphorylation.
• Importantly, the downregulated factors comprise PGC-1α, a key factor in mitochondrial biogenesis and renal energy homeostasis, to be substantially downregulated in MARV-infected PTC.
• Our results suggest inflammation-induced changes in tubular energy metabolism as a possible factor in MARV-associated tubular dysfunction.
Abstract
Marburg virus, a member of the Filoviridae, is the causative agent of Marburg virus disease (MVD), a hemorrhagic fever with a case fatality rate of up to 90 %. Acute kidney injury is common in MVD and is associated with increased mortality, but its pathogenesis in MVD remains poorly understood. Interestingly, autopsies show the presence of viral proteins in different parts of the nephron, particularly in proximal tubular cells (PTC). These findings suggest a potential role for the virus in the development of MVD-related kidney injury. To shed light on this effect, we infected primary human PTC with Lake Victoria Marburg virus and conducted transcriptomic analysis at multiple time points. Unexpectedly, infection did not induce marked cytopathic effects in primary tubular cells at 20 and 40 h post infection. However, gene expression analysis revealed robust renal viral replication and dysregulation of genes essential for different cellular functions. The gene sets mainly downregulated in PTC were associated with the targets of the transcription factors MYC and E2F, DNA repair, the G2M checkpoint, as well as oxidative phosphorylation. Importantly, the downregulated factors comprise PGC-1α, a well-known factor in acute and chronic kidney injury. By contrast, the most highly upregulated gene sets were those related to the inflammatory response and cholesterol homeostasis. In conclusion, Marburg virus infects and replicates in human primary PTC and induces downregulation of processes known to be relevant for acute kidney injury as well as a strong inflammatory response.