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Aim: Cellular CD81 is a well characterized hepatitis C virus (HCV) entry factor, while the relevance of soluble exosomal CD81 in HCV pathogenesis is poorly defined. We performed a case-control study to investigate whether soluble CD81 in the exosomal serum fraction is associated with HCV replication and inflammatory activity.
Patients and Methods: Four cohorts were investigated, patients with chronic hepatitis C (n = 37), patients with chronic HCV infection and persistently normal ALT levels (n = 24), patients with long term sustained virologic response (SVR, n = 7), and healthy volunteers (n = 23). Concentration of soluble CD81 was assessed semi-quantitatively after differential centrifugation ranging from 200 g to 100,000 g in the fifth centrifugation fraction by immunoblotting and densitometry.
Results: Soluble CD81 was increased in patients with chronic hepatitis C compared to healthy subjects (p = 0.03) and cured patients (p = 0.017). Patients with chronic HCV infection and persistently normal ALT levels and patients with long term SVR had similar soluble CD81 levels as healthy controls (p>0.2). Overall, soluble CD81 levels were associated with ALT levels (r = 0.334, p = 0.016) and severe liver fibrosis (p = 0.027).
Conclusion: CD81 is increased in the exosomal serum fraction in patients with chronic hepatitis C and appears to be associated with inflammatory activity and severity of fibrosis.
Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice
(2012)
Lung ischaemia–reperfusion-induced oedema (LIRE) is a life-threatening condition that causes pulmonary oedema induced by endothelial dysfunction. Here we show that lungs from mice lacking nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox2y/−) or the classical transient receptor potential channel 6 (TRPC6−/−) are protected from LIR-induced oedema (LIRE). Generation of chimeric mice by bone marrow cell transplantation and endothelial-specific Nox2 deletion showed that endothelial Nox2, but not leukocytic Nox2 or TRPC6, are responsible for LIRE. Lung endothelial cells from Nox2- or TRPC6-deficient mice showed attenuated ischaemia-induced Ca2+ influx, cellular shape changes and impaired barrier function. Production of reactive oxygen species was completely abolished in Nox2y/− cells. A novel mechanistic model comprising endothelial Nox2-derived production of superoxide, activation of phospholipase C-γ, inhibition of diacylglycerol (DAG) kinase, DAG-mediated activation of TRPC6 and ensuing LIRE is supported by pharmacological and molecular evidence. This mechanism highlights novel pharmacological targets for the treatment of LIRE.
Exil und Migration : minoritäres Schreiben auf Deutsch im 20. Jahrhundert - von Kafka bis Zaimoglu
(2012)
Die Begriffe 'Exil' und 'Migration' miteinander in Beziehung zu setzen erscheint zugleich zwingend und erklärungsbedürftig. Zwingend ist es aus systematischen Gründen, denn wer freiwillig oder gezwungenermaßen seine Heimat verlässt um ins Exil zu gehen, der wandert aus und wird zum Migranten. Für viele der nach 1933 vor den Nationalsozialisten Geflohenen begann mit der Flucht oder Vertreibung eine fundamental unsichere Zeit des Unterwegsseins, die in dem Maße wie sich der nationalsozialistische Herrschaftsbereich ausdehnte immer neue Ziele und Aufenthaltsorte bedeutete. Fast alle Migrantinnen und Migranten haben nach der Vertreibung, dem Verlust ihres bisherigen Daseins, extrem schwierige Arbeits- und Lebensbedingungen vorgefunden. Den Kunstschaffenden, vor allem den Schriftstellern, fehlte mit einem Schlag das muttersprachliche Umfeld und ein entsprechendes Publikum, was viele in ihrer intellektuellen und wirtschaftlichen Existenz bedrohte.
Das alles ist bekannt. Erklärungswürdig ist die Rede von 'Migration' gegenüber dem in der Forschungstradition häufigeren Begriff 'Emigration'. 'Migration' betont den Prozesscharakter des Auswanderns, was historisch plausibel ist und, darum soll es im Folgenden gehen, neue literaturgeschichtliche und literaturtheoretische Anschlussmöglichkeiten eröffnet. Die Beschäftigung mit den Texten, die unter den schwierigen Bedingungen des Exils entstanden sind, hat in der Nachfolge der Pionierarbeit von Walter A. Berendsohn innerhalb der Germanistik einen eigenständigen Forschungszweig hervorgebracht, dessen Institutionalisierung fortwährend von Methodendiskussionen begleitet worden ist.
Background: Adaptation to low oxygen by changing gene expression is vitally important for cell survival and tissue development. The sprouting of new blood vessels, initiated from endothelial cells, restores the oxygen supply of ischemic tissues. In contrast to the transcriptional response induced by hypoxia, which is mainly mediated by members of the HIF family, there are only few studies investigating alternative splicing events. Therefore, we performed an exon array for the genome-wide analysis of hypoxia-related changes of alternative splicing in endothelial cells.
Methodology/Principal findings: Human umbilical vein endothelial cells (HUVECs) were incubated under hypoxic conditions (1% O(2)) for 48 h. Genome-wide transcript and exon expression levels were assessed using the Affymetrix GeneChip Human Exon 1.0 ST Array. We found altered expression of 294 genes after hypoxia treatment. Upregulated genes are highly enriched in glucose metabolism and angiogenesis related processes, whereas downregulated genes are mainly connected to cell cycle and DNA repair. Thus, gene expression patterns recapitulate known adaptations to low oxygen supply. Alternative splicing events, until now not related to hypoxia, are shown for nine genes: six which are implicated in angiogenesis-mediated cytoskeleton remodeling (cask, itsn1, larp6, sptan1, tpm1 and robo1); one, which is involved in the synthesis of membrane-anchors (pign) and two universal regulators of gene expression (cugbp1 and max).
Conclusions/Significance: For the first time, this study investigates changes in splicing in the physiological response to hypoxia on a genome-wide scale. Nine alternative splicing events, until now not related to hypoxia, are reported, considerably expanding the information on splicing changes due to low oxygen supply. Therefore, this study provides further knowledge on hypoxia induced gene expression changes and presents new starting points to study the hypoxia adaptation of endothelial cells.
The Alpine Region, constituting the Alps and the Dinaric Alps, has played a major role in the formation of current patterns of biodiversity either as a contact zone of postglacial expanding lineages or as the origin of genetic diversity. In our study, we tested these hypotheses for two widespread, sympatric microgastropod taxa - Carychium minimum O.F. Müller, 1774 and Carychium tridentatum (Risso, 1826) (Gastropoda, Eupulmonata, Carychiidae) - by using COI sequence data and species potential distribution models analyzed in a statistical phylogeographical framework. Additionally, we examined disjunct transatlantic populations of those taxa from the Azores and North America. In general, both Carychium taxa demonstrate a genetic structure composed of several differentiated haplotype lineages most likely resulting from allopatric diversification in isolated refugial areas during the Pleistocene glacial periods. However, the genetic structure of Carychium minimum is more pronounced, which can be attributed to ecological constraints relating to habitat proximity to permanent bodies of water. For most of the Carychium lineages, the broader Alpine Region was identified as the likely origin of genetic diversity. Several lineages are endemic to the broader Alpine Region whereas a single lineage per species underwent a postglacial expansion to (re)colonize previously unsuitable habitats, e.g. in Northern Europe. The source populations of those expanding lineages can be traced back to the Eastern and Western Alps. Consequently, we identify the Alpine Region as a significant 'hot-spot' for the formation of genetic diversity within European Carychium lineages. Passive dispersal via anthropogenic means best explains the presence of transatlantic European Carychium populations on the Azores and in North America. We conclude that passive (anthropogenic) transport could mislead the interpretation of observed phylogeographical patterns in general.
Max Frisch gilt nicht als 'Achtundsechziger' und schon gar nicht als Autor von 'Achtundsechziger'-Literatur. Mit Jahrgang 1911 ist er zunächst schlicht zu alt dafür, denn gemäß gängiger, an Generationengrenzen orientierter Definition darf ein 'Achtundsechziger' im Jahr 1968 zwanzig bis maximal dreißig Lebensjahre zählen. Zudem trennen Frisch Ablehnung eines dogmatisch vertretenen Marxismus und Skepsis gegenüber jeder ungebrochenen Revolutionseuphorie von den (studentischen) Aufbruchsbewegten der Zeit, auch wenn er sich als - freilich demokratischer - "Sozialist" bezeichnet und insbesondere im einschlägigen zweiten Tagebuch, dem 1972 veröffentlichten Tagebuch 1966-1971, Sympathie für die Anliegen der Demonstranten bekundet und den Vietnam-Krieg der USA kritisiert.
In Studien zu Literatur um 1968 kommen Frischs Werke nicht vor, denn sie wecken keine Assoziationen mit Genres wie 'littérature engagée', 'Protest-Literatur' oder 'Agitprop'. Im Gegenteil, gerne wird der Literatur dieses Autors im Allgemeinen oder sogar gerade seinen Texten um 1968 im Speziellen jeglicher "Eingriff in die Politik", jede "direkte und offene Gesellschaftskritik" abgesprochen. Ich-Bezogenheit, Konzentration aufs Private (generell oder als Reprivatisierung speziell in jener Zeit), Beschäftigung mit 'ewigen' Themen wie Identität, Beziehungen, Alter, Vergänglichkeit, Tod - so lauten dagegen die dominanten Kennzeichnungen. Distanz zur 'littérature engagée', zu einer direkt politisch motivierten bzw. motivierenden Literatur, hat Frisch auch selbst immer wieder markiert, obwohl oder gerade weil er sich zugleich politisch engagiert hat. So unterstreicht er etwa in seiner Eröffnungsrede auf der Frankfurter Dramaturgen-Tagung von 1964, dass "das politische Engagement nicht der Impuls" des Schreibens sei und sein soll, sondern höchstens sekundär "ein Ergebnis der [literarischen] Produktion".
Background: Panic disorder is common (5% prevalence) and females are twice as likely to be affected as males. The heritable component of panic disorder is estimated at 48%. Glutamic acid dehydrogenase GAD1, the key enzyme for the synthesis of the inhibitory and anxiolytic neurotransmitter GABA, is supposed to influence various mental disorders, including mood and anxiety disorders. In a recent association study in depression, which is highly comorbid with panic disorder, GAD1 risk allele associations were restricted to females.
Methodology/Principal Findings: Nineteen single nucleotide polymorphisms (SNPs) tagging the common variation in GAD1 were genotyped in two independent gender and age matched case-control samples (discovery sample n = 478; replication sample n = 584). Thirteen SNPs passed quality control and were examined for gender-specific enrichment of risk alleles associated with panic disorder by using logistic regression including a genotype×gender interaction term. The latter was found to be nominally significant for four SNPs (rs1978340, rs3762555, rs3749034, rs2241165) in the discovery sample; of note, the respective minor/risk alleles were associated with panic disorder only in females. These findings were not confirmed in the replication sample; however, the genotype×gender interaction of rs3749034 remained significant in the combined sample. Furthermore, this polymorphism showed a nominally significant association with the Agoraphobic Cognitions Questionnaire sum score.
Conclusions/Significance: The present study represents the first systematic evaluation of gender-specific enrichment of risk alleles of the common SNP variation in the panic disorder candidate gene GAD1. Our tentative results provide a possible explanation for the higher susceptibility of females to panic disorder.
Development of single-port cholecystectomy : results of a case-control study matched to one surgeon
(2012)
Background: Single-port laparoscopic cholecystectomy is an evolving technique which is now widely established. Up until now, the safety of the procedure and a respective learning curve have not been adequately reported in most studies. The aim of this study was to demonstrate that single-port cholecystectomy is a safe procedure, with a positive learning curve from a case-control study matched to one surgeon.
Methods: One hundred single-port cholecystectomies performed by one surgeon (AB) were retrospectively matched to 100 patients who underwent conventional laparoscopic cholecystectomy carried out by the same surgeon. The two groups were matched in respect of surgical indication, gender, age, and body mass index. The groups were compared with respect to operation time, use of additional trocars, analgesics required in the post anesthesia care unit, postoperative complications, and duration of hospital stay.
Results: No significant difference was found between the two groups with respect to postoperative complications and stay in hospital. The operation time increased slightly in the single-port group. Directly after the operation, the analgesic use required in the post anesthesia care unit was higher in the single-port group. Consumption of analgesics on the surgical ward was very similar in each group. In respect to the learning curve, the operation time and use of additional trocars showed a positive trend, starting with the thirtieth operation.
Conclusion: Single-port cholecystectomy is a feasible and safe procedure in a specialist setting. The procedure can be done under the same safety rules as those for conventional laparoscopic cholecystectomy. Considering the learning curve, starting with the thirtieth operation, a positive trend was seen. Long-term studies will be needed to establish the incidence and rate of incisional hernias.
Tagungsbericht: Playing False : representations of Betrayal
16. bis 17. September 2011, Lincoln College, Oxford University
From antiquity through the present, from the political sphere to the most personal relationships, betrayal is a ubiquitous and multifaceted phenomenon. Because of its many forms, however, betrayal demands an intensive examination within an interdisciplinary forum that transcends the narrower, political or literary spheres of betrayal, and that strives to address the multiplicity of its representations, rather than reducing it to a single definition. It is precisely such a forum that the conference, "Playing False: Representations of Betrayal" created, which Dr. Betiel Wasihun and Kristina Mendicino organized.
Purpose: Student circus artists train as both artists and athletes with their bodies holding the key to professional success. The daily training load of student circus artists is often associated with maximum physical and psychological stress with injuries posing a threat to a potential professional career. The purpose of this study is the differentiated analysis and evaluation of work accidents in order to initiate the development of injury preventive programs.
Methods: The 17 years of data were obtained from standardized anonymous work accident records of the Berlin State Accident Insurance (UKB) as well as a State Artist Educational School (n = 169, Male: 70; Female: 99) from student artists. Evaluation and descriptive statistics were conducted with Excel 2007 and PASW Statistics 18.
Results: The injury risk seems to be relatively low (0.3 injuries/1000h). There are gender specific differences as to the location of injuries. Only 7% of the accidents demand a break of more than 3 days. Injury patterns vary depending on the activity and the employment of props/equipment. 75.2% of work accidents have multifactorial and 24.8% exogenous causes.
Conclusions: Because physical fitness is all important in the circus arts there are numerous options for injury prevention programs that should be realized subject to gender-specific differences. Follow-ups on chronic complaints and a more individual approach are indispensable due to the very specific activities in the circus arts.
Altered metabolism in tumor cells is increasingly recognized as a core component of the neoplastic phenotype. Because p53 has emerged as a master metabolic regulator, we hypothesized that the presence of wild-type p53 in glioblastoma cells could confer a selective advantage to these cells under the adverse conditions of the glioma microenvironment. Here, we report on the effects of the p53-dependent effector Tp53-induced glycolysis and apoptosis regulator (TIGAR) on hypoxia-induced cell death. We demonstrate that TIGAR is overexpressed in glioblastomas and that ectopic expression of TIGAR reduces cell death induced by glucose and oxygen restriction. Metabolic analyses revealed that TIGAR inhibits glycolysis and promotes respiration. Further, generation of reactive oxygen species (ROS) levels was reduced whereas levels of reduced glutathione were elevated in TIGAR-expressing cells. Finally, inhibiting the transketolase isoenzyme transketolase-like 1 (TKTL1) by siRNA reversed theses effects of TIGAR. These findings suggest that glioma cells benefit from TIGAR expression by (i) improving energy yield from glucose via increased respiration and (ii) enhancing defense mechanisms against ROS. Targeting metabolic regulators such as TIGAR may therefore be a valuable strategy to enhance glioma cell sensitivity toward spontaneously occurring or therapy-induced starvation conditions or ROS-inducing therapeutic approaches.
Infants' poor motor abilities limit their interaction with their environment and render studying infant cognition notoriously difficult. Exceptions are eye movements, which reach high accuracy early, but generally do not allow manipulation of the physical environment. In this study, real-time eye tracking is used to put 6- and 8-month-old infants in direct control of their visual surroundings to study the fundamental problem of discovery of agency, i.e. the ability to infer that certain sensory events are caused by one's own actions. We demonstrate that infants quickly learn to perform eye movements to trigger the appearance of new stimuli and that they anticipate the consequences of their actions in as few as 3 trials. Our findings show that infants can rapidly discover new ways of controlling their environment. We suggest that gaze-contingent paradigms offer effective new ways for studying many aspects of infant learning and cognition in an interactive fashion and provide new opportunities for behavioral training and treatment in infants.
Pre-publication peer review of scientific literature in its present state suffers from a lack of evaluation validity and transparency to the community. Inspired by social networks, we propose a framework for the open exchange of post-publication evaluation to complement the current system. We first formulate a number of necessary conditions that should be met by any design dedicated to perform open scientific evaluation. To introduce our framework, we provide a basic data standard and communication protocol. We argue for the superiority of a provider-independent framework, over a few isolated implementations, which allows the collection and analysis of open evaluation content across a wide range of diverse providers like scientific journals, research institutions, social networks, publishers websites, and more. Furthermore, we describe how its technical implementation can be achieved by using existing web standards and technology. Finally, we illustrate this with a set of examples and discuss further potential.
Ubiquitination now ranks with phosphorylation as one of the best-studied post-translational modifications of proteins with broad regulatory roles across all of biology. Ubiquitination usually involves the addition of ubiquitin chains to target protein molecules, and these may be of eight different types, seven of which involve the linkage of one of the seven internal lysine (K) residues in one ubiquitin molecule to the carboxy-terminal diglycine of the next. In the eighth, the so-called linear ubiquitin chains, the linkage is between the amino-terminal amino group of methionine on a ubiquitin that is conjugated with a target protein and the carboxy-terminal carboxy group of the incoming ubiquitin. Physiological roles are well established for K48-linked chains, which are essential for signaling proteasomal degradation of proteins, and for K63-linked chains, which play a part in recruitment of DNA repair enzymes, cell signaling and endocytosis. We focus here on linear ubiquitin chains, how they are assembled, and how three different avenues of research have indicated physiological roles for linear ubiquitination in innate and adaptive immunity and suppression of inflammation.
Background: Liver cirrhosis is associated with high morbidity and mortality. MicroRNAs (miRs) circulating in the blood are an emerging new class of biomarkers. In particular, the serum level of the liver-specific miR-122 might be a clinically useful new parameter in patients with acute or chronic liver disease.
Aim: Here we investigated if the serum level of miR-122 might be a prognostic parameter in patients with liver cirrhosis.
Methods: 107 patients with liver cirrhosis in the test cohort and 143 patients in the validation cohort were prospectively enrolled into the present study. RNA was extracted from the sera obtained at the time of study enrollment and the level of miR-122 was assessed. Serum miR-122 levels were assessed by quantitative reverse-transcription PCR (RT-PCR) and were compared to overall survival time and to different complications of liver cirrhosis.
Results: Serum miR-122 levels were reduced in patients with hepatic decompensation in comparison to patients with compensated liver disease. Patients with ascites, spontaneous bacterial peritonitis and hepatorenal syndrome had significantly lower miR-122 levels than patients without these complications. Multivariate Cox regression analysis revealed that the miR-122 serum levels were associated with survival independently from the MELD score, sex and age.
Conclusions: Serum miR-122 is a new independent marker for prediction of survival of patients with liver cirrhosis.
Hereditary angioedema (HAE) in children and adolescents : a consensus on therapeutic strategies
(2012)
Hereditary angioedema due to C1 inhibitor (C1 esterase inhibitor) deficiency (types I and II HAE-C1-INH) is a rare disease that usually presents during childhood or adolescence with intermittent episodes of potentially life-threatening angioedema. Diagnosis as early as possible is important to avoid ineffective therapies and to properly treat swelling attacks. At a consensus meeting in June 2011, pediatricians and dermatologists from Germany, Austria, and Switzerland reviewed the currently available literature, including published international consensus recommendations for HAE therapy across all age groups. Published recommendations cannot be unconditionally adopted for pediatric patients in German-speaking countries given the current approval status of HAE drugs. This article provides an overview and discusses drugs available for HAE therapy, their approval status, and study results obtained in adult and pediatric patients. Recommendations for developing appropriate treatment strategies in the management of HAE in pediatric patients in German-speaking countries are provided.Conclusion Currently, plasma-derived C1 inhibitor concentrate is considered the best available option for the treatment of acute HAE-C1-INH attacks in pediatric patients in German-speaking countries, as well as for short-term and long-term prophylaxis.
Im römischen Goldbergwerksdistrikt von Três Minas (Freg. Três Minas, Conc. Vila Pouca de Aguiar / Portugal) haben sich in einem seitlichen Treppenschacht der Galeria dos Alargamentos Spuren eines Grubenunglücks und einer darauf folgenden Rettungsaktion erhalten. Dieser bisher einmalige Befund stellt eine interessante Bereicherung für die antike Bergbauforschung dar.
Background: The blood-brain barrier (BBB) represents an insurmountable obstacle for most drugs thus obstructing an effective treatment of many brain diseases. One solution for overcoming this barrier is a transport by binding of these drugs to surface-modified nanoparticles. Especially apolipoprotein E (ApoE) appears to play a major role in the nanoparticle-mediated drug transport across the BBB. However, at present the underlying mechanism is incompletely understood.
Methodology/Principal Findings: In this study, the uptake of the ApoE-modified nanoparticles into the brain capillary endothelial cells was investigated to differentiate between active and passive uptake mechanism by flow cytometry and confocal laser scanning microscopy. Furthermore, different in vitro co-incubation experiments were performed with competing ligands of the respective receptor.
Conclusions/Significance: This study confirms an active endocytotic uptake mechanism and shows the involvement of low density lipoprotein receptor family members, notably the low density lipoprotein receptor related protein, on the uptake of the ApoE-modified nanoparticles into the brain capillary endothelial cells. This knowledge of the uptake mechanism of ApoE-modified nanoparticles enables future developments to rationally create very specific and effective carriers to overcome the blood-brain barrier.
Spiders from the Tirana district of Albania were investigated. Currently, 78 species from 24 families and a collection of 400 specimens from January to August 2010 were recorded for Tirana. A total of 32 new records for the Albanian fauna are included in the present paper. Agraecina lineata (Simon, 1878) is the first record for the Balkan Peninsula. Saitis graecus Kulczyński, 1905 was known before only from Greece and Bulgaria. Presently, 373 spider species are known for Albania.
The present study unites data from several excursions in typical Mediterranean lowland ecosystems in Albania during the years 2006 to 2009. Spiders from several different habitat types along the coast were analysed in six districts: Saranda, Fieri, Kavaja, Durrësi, Tirana and Lezha. In total 299 adult specimens were collected. They belong to 82 species, 60 genera and 22 families. Six species are new to the Albanian fauna: Aculepeira armida (Audouin, 1826), Zygiella x-notata (Clerck, 1757), Histopona torpida (C. L. Koch, 1837), Malthonica campestris (C. L. Koch, 1834), Pellenes tripunctatus (Walckenaer, 1802) and Pseudeuophrys erratica (Walckenaer, 1826). With respect to zoogeography, the spider fauna is mainly characterized by the presence of many Palaearctic species.
“Far, far away from our areas, somewhere beyond the Mountains of Darkness, on the other side of the Sambatyon River…there lives a nation known as the Red Jews.” The Red Jews are best known from classic Yiddish writing, most notably from Mendele's Kitser masoes Binyomin hashlishi (The Brief Travels of Benjamin the Third). This novel, first published in 1878, represents the initial appearance of the Red Jews in modern Yiddish literature. This comical travelogue describes the adventures of Benjamin, who sets off in search of the legendary Red Jews. But who are these Red Jews or, in Yiddish, di royte yidelekh? The term denotes the Ten Lost Tribes of Israel, the ten tribes that in biblical times had composed the Northern Kingdom of Israel until they were exiled by the Assyrians in the eighth century BCE. Over time, the myth of their return emerged, and they were said to live in an uncharted location beyond the mysterious Sambatyon River, where they would remain until the Messiah's arrival at the end of time, when they would rejoin the rest of the Jewish people.
This article is part of a broader study of the Red Jews in Jewish popular culture from the Middle Ages through modernity. It is partially based on a chapter from my book, Umstrittene Erlöser: Politik, Ideologie und jüdisch-christlicher Messianismus in Deutschland, 1500–1600 (Göttingen: Vandenhoeck & Ruprecht, 2011). Several postdoctoral fellowships have generously supported my research on the Red Jews: a Dr. Meyer-Struckmann-Fellowship of the German Academic Foundation, a Harry Starr Fellowship in Judaica/Alan M. Stroock Fellowship for Advanced Research in Judaica at Harvard University, a research fellowship from the Heinrich Hertz-Foundation, and a YIVO Dina Abramowicz Emerging Scholar Fellowship. I thank the organizers of and participants in the colloquia and conferences where I have presented this material in various forms as well as the editors and anonymous reviewers of AJS Review for their valuable comments and suggestions. I am especially grateful to Jeremy Dauber and Elisheva Carlebach of the Institute for Israel and Jewish Studies at Columbia University, where I was a Visiting Scholar in the fall of 2009, for their generous encouragement to write this article. Sue Oren considerably improved my English. The style employed for Romanization of Yiddish follows YIVO's transliteration standards. Unless otherwise noted, translations from the Yiddish, Hebrew, German, and Latin are my own. Quotations from the Bible follow the JPS translation, and those from the Babylonian Talmud are according to the Hebrew-English edition of the Soncino Talmud by Isidore Epstein.
Als der Filmproduzent Franco Rossellini 1969 den Kontakt zwischen Pasolini und Maria Callas herstellte, brachte er nicht nur zwei der außergewöhnlichsten Künstler des 20. Jahrhunderts - beide stolz und zerbrechlich, archaisch und modern - für die Arbeit am Set von Pasolinis Euripides-Verfilmung Medea zusammen. Zugleich ergab sich dadurch eine intersubjektive Konstellation, die - im Schmelztiegel einer intensiven, aber tragischen Freundschaft und Zuneigung - den mythischen Unterstrom hervorquellen ließ, der die besondere Existenz und das künstlerische Werk Pasolinis gleichermaßen grundiert und zusammenschmiedet. Es ist das Magma der tellurischen Mächte, das die Verschmelzung von Leben und Poesie zu einer "corporeita pasoliniana", zur pasolinispezifischen "Körperlichkeit der poetischen Aktion" (Giovanni Giudici) erhellen kann, ohne sie einem subjektiven Willkürakt zuzuschreiben.
We describe and analyze a Neandertal postcranial skeleton and dentition, which together show unambiguous signs of right-handedness. Asymmetries between the left and right upper arm in Regourdou 1 were identified nearly 20 years ago, then confirmed by more detailed analyses of the inner bone structure for the clavicle, humerus, radius and ulna. The total pattern of all bones in the shoulder and arm reveals that Regourdou 1 was a right-hander. Confirmatory evidence comes from the mandibular incisors, which display a distinct pattern of right oblique scratches, typical of right-handed manipulations performed at the front of the mouth. Regourdou's right handedness is consistent with the strong pattern of manual lateralization in Neandertals and further confirms a modern pattern of left brain dominance, presumably signally linguistic competence. These observations along with cultural, genetic and morphological evidence indicate language competence in Neandertals and their European precursors.
Erst in seinen letzten Lebensjahren in Berlin hat Kafka sich intensiver in Kursen der 'Hochschule für die Wissenschaft des Judentums' mit dem Talmud befasst: "Er hört in der Präparandie Professor Torczyner und Professor Guttmanns Vorträge über den Talmud. Er liest leichtere hebräische Texte. Nur dieser Kurse wegen kommt er regelmäßig aus dem stillen Vorort nach Berlin." Aus dieser Erfahrung heraus schrieb Kafka Ende 1923 an Robert Klopstock: "Daß Sie in die Iwriah gehen wollen, ist sehr gut, vielleicht nicht nur in die Hebräischkurse, sondern auch zu der Talmudstunde (einmal wöchentlich!, Sie werden es nicht ganz verstehn, was tut es? Aus der Ferne werden Sie es hören, was sind es sonst, als Nachrichten aus der Ferne)." Was aber heißt bei Kafka 'aus der Ferne'? Wäre nicht auch 'Eine kaiserliche Botschaft', hätte sie den Adressaten erreicht, aus der Ferne gekommen?
To study the effect of galactic cosmic rays on aerosols and clouds, the Cosmics Leaving OUtdoor Droplets (CLOUD) project was established. Experiments are carried out at a 26.1 m3 tank at CERN (Switzerland). In the experiments, the effect of ionizing radiation on H2SO4 particle formation and growth is investigated. To evaluate the experimental configuration, the experiment was simulated using a coupled multidimensional computational fluid dynamics (CFD) – particle model. In the model the coupled fields of gas/vapor species, temperature, flow velocity and particle properties were computed to investigate mixing state and mixing times of the CLOUD tank's contents. Simulation results show that a 1-fan configuration, as used in first experiments, may not be sufficient to ensure a homogeneously mixed chamber. To mix the tank properly, two fans and sufficiently high fan speeds are necessary. The 1/e response times for instantaneous changes of wall temperature and saturation ratio were found to be in the order of few minutes. Particle nucleation and growth was also simulated and particle number size distribution properties of the freshly nucleated particles (particle number, mean size, standard deviation of the assumed log-normal distribution) were found to be distributed over the tank's volume similar to the gas species.
Wie erkennen wir Neues in der Politik, und wie bewerten wir dieses Neue, wenn es darauf abzielt, die vertrauten politischen Maßstäbe und -einheiten in Frage zu stellen? Die Piratenpartei als neueste Erscheinung in der bundesrepublikanischen Politik erlaubt es, diesem Problem nicht nur abstrakt nachzugehen. Meine Ausgangshypothese verortet das Neue weder im von der Piratenpartei eingebrachten Thema, noch in einer besonderen Position, die sie innerhalb des politischen Spektrums bezieht, sondern in ihrem Vorschlag, die Art und Weise zu verändern, wie politische Macht in der deutschen Demokratie ausgeübt wird: den Modus demokratischer Herrschaft von Repräsentation auf liquid democracy umzustellen. ...
These proceedings will cover various studies of hadronic resonances within the UrQMD transport model. After a brief explanation of the model, various observables will be highlighted and the chances for resonance reconstruction in hadronic channels will be discussed. Possible signals of chiral symmetry restoration will be investigated for feasibility.
Dimitré Dinev schreibt seit den frühen 1990er Jahren Texte auf Deutsch, dennoch wurde er erst mit seinem Roman "Engelszungen" (2003) einer breiteren Öffentlichkeit bekannt. Mit Bezug auf Pierre Bourdieus Konzept des literarischen Feldes untersucht der folgende Beitrag die Gründe für diesen späten Erfolg, dokumentiert, wie Dimitré Dinev im literarischen Feld aufgenommen wurde und wie er von der Kritik, den LeserInnen, LiteraturwissenschaftlerInnen und anderen Protagonisten im Feld rezipiert wurde und wird. Veränderungen in der Rezeption und damit in der Position/Positionierung im literarischen Feld werden thematisiert. Hinterfragt werden soll, welche Rolle Dinevs (osteuropäische) Herkunft in der Rezeption seiner Texte spielt. Der vorgeschlagene Beitrag setzt sich sowohl mit Dinevs Prosatexten (auch den in Anthologien erschienenen) als auch mit seiner Tätigkeit als Dramatiker auseinander und sieht den Autor zudem als Mittler für bulgarische Literatur im deutschsprachigen Raum.
Denervation-induced changes in excitatory synaptic strength were studied following entorhinal deafferentation of hippocampal granule cells in mature (≥3 weeks old) mouse organotypic entorhino-hippocampal slice cultures. Whole-cell patch-clamp recordings revealed an increase in excitatory synaptic strength in response to denervation during the first week after denervation. By the end of the second week synaptic strength had returned to baseline. Because these adaptations occurred in response to the loss of excitatory afferents, they appeared to be in line with a homeostatic adjustment of excitatory synaptic strength. To test whether denervation-induced changes in synaptic strength exploit similar mechanisms as homeostatic synaptic scaling following pharmacological activity blockade, we treated denervated cultures at 2 days post lesion for 2 days with tetrodotoxin. In these cultures, the effects of denervation and activity blockade were not additive, suggesting that similar mechanisms are involved. Finally, we investigated whether entorhinal denervation, which removes afferents from the distal dendrites of granule cells while leaving the associational afferents to the proximal dendrites of granule cells intact, results in a global or a local up-scaling of granule cell synapses. By using computational modeling and local electrical stimulations in Strontium (Sr2+)-containing bath solution, we found evidence for a lamina-specific increase in excitatory synaptic strength in the denervated outer molecular layer at 3–4 days post lesion. Taken together, our data show that entorhinal denervation results in homeostatic functional changes of excitatory postsynapses of denervated dentate granule cells in vitro.
The crystal structure of the title compound, Na[(C6F5)BH3], is composed of discrete anions and cations. The sodium cations are surrounded by four anions with three short Na...B [2.848 (8), 2.842 (7) and 2.868 (8) Å] and two short Na...F contacts [2.348 (5) and 2.392 (5) Å], forming a three-dimensional network. The anion is the first structural example of a pentafluorophenyl ring carrying a BH3 group.
In February 2012, Odonata were recorded and voucher specimens collected in Luzon, The Philippines. The focus of study was set on localities near Dinapigue and San Mariano (Isabela Province), sites in Casiguran (Aurora Province) and on Polillo Island (Quezon Province). 60 Odonata species were recorded. Three are new to science and have been formally to be described. Four species were recorded for the first time in Luzon. Amphicnemis furcata and Diplacodes nebulosa were rediscovered after several decades since they were last documented from Luzon.
The aim of this article is to show the difference between an interpretative-hermeneutic ethnographic approach deeply embedded in the history of anthropology and ethnographic methods introduced as part of a social science repertoire. Taking the classical "network" as an example, it contrasts the way this concept is generally used in studies on translocal mobility with interpretations of ethnographic research. This not only opens up critical reflections on the role of "networks" when it comes to understanding translocality as a lived experience, but also illustrates what it actually means to follow an interpretative-hermeneutic approach in which ethnographic material is seen to serve as a way to ground, question and refine abstract concepts. The article thus argues that it is through ethnographies and their inherent openness towards the field that a more enriching and creative engagement with theories and methodologies can be achieved than qualitative social science approaches usually allow for.
Background: Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly attributable to co-infection with hepatitis B or C. The impact of other risk factors, including prolonged exposure to combined antiretroviral therapy (cART) is poorly understood. Our aim was to determine the prevalence of liver fibrosis and associated risk factors in HIV-infected individuals based on non-invasive fibrosis assessment using transient elastography (TE) and serum biomarkers (Fibrotest [FT]).
Methods: In 202 consecutive HIV-infected individuals (159 men; mean age 47 ± 9 years; 35 with hepatitis-C-virus [HCV] co-infection), TE and FT were performed. Repeat TE examinations were conducted 1 and 2 years after study inclusion.
Results: Significant liver fibrosis was present in 16% and 29% of patients, respectively, when assessed by TE (≥ 7.1 kPa) and FT (> 0.48). A combination of TE and FT predicted significant fibrosis in 8% of all patients (31% in HIV/HCV co-infected and 3% in HIV mono-infected individuals). Chronic ALT, AST and γ-GT elevation was present in 29%, 20% and 51% of all cART-exposed patients and in 19%, 8% and 45.5% of HIV mono-infected individuals. Overall, factors independently associated with significant fibrosis as assessed by TE (OR, 95% CI) were co-infection with HCV (7.29, 1.95-27.34), chronic AST (6.58, 1.30-33.25) and γ-GT (5.17, 1.56-17.08) elevation and time on dideoxynucleoside therapy (1.01, 1.00-1.02). In 68 HIV mono-infected individuals who had repeat TE examinations, TE values did not differ significantly during a median follow-up time of 24 months (median intra-patient changes at last TE examination relative to baseline: -0.2 kPa, p = 0.20).
Conclusions: Chronic elevation of liver enzymes was observed in up to 45.5% of HIV mono-infected patients on cART. However, only a small subset had significant fibrosis as predicted by TE and FT. There was no evidence for fibrosis progression during follow-up TE examinations.
Background and Aims: The prevalence of hepatitis C virus (HCV) antibodies in Germany has been estimated to be in the range of 0.4–0.63%. Screening for HCV is recommended in patients with elevated ALT levels or significant risk factors for HCV transmission only. However, 15–30% of patients report no risk factors and ALT levels can be normal in up to 20–30% of patients with chronic HCV infection. The aim of this study was to assess the HCV seroprevalence in patients visiting two tertiary care emergency departments in Berlin and Frankfurt, respectively.
Methods: Between May 2008 and March 2010, a total of 28,809 consecutive patients were screened for the presence of anti-HCV antibodies. Anti-HCV positive sera were subsequently tested for HCV-RNA.
Results: The overall HCV seroprevalence was 2.6% (95% CI: 2.4–2.8; 2.4% in Berlin and 3.5% in Frankfurt). HCV-RNA was detectable in 68% of anti-HCV positive cases. Thus, the prevalence of chronic HCV infection in the overall study population was 1.6% (95% CI 1.5–1.8). The most commonly reported risk factor was former/current injection drug use (IDU; 31.2%) and those with IDU as the main risk factor were significantly younger than patients without IDU (p<0.001) and the male-to-female ratio was 72% (121 vs. 46 patients; p<0.001). Finally, 18.8% of contacted HCV-RNA positive patients had not been diagnosed previously.
Conclusions: The HCV seroprevalence was more than four times higher compared to current estimates and almost one fifth of contacted HCV-RNA positive patients had not been diagnosed previously.
Background and Aims: Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV infection in Asian populations. Most significant associations were observed for the A alleles of HLA-DPA1 rs3077 and HLA-DPB1 rs9277535, which conferred a decreased risk for HBV infection. We assessed the implications of these variants for HBV infection in Caucasians.
Methods: Two HLA-DP gene variants (rs3077 and rs9277535) were analyzed for associations with persistent HBV infection and with different clinical outcomes, i.e., inactive HBsAg carrier status versus progressive chronic HBV (CHB) infection in Caucasian patients (n = 201) and HBsAg negative controls (n = 235).
Results: The HLA-DPA1 rs3077 C allele was significantly associated with HBV infection (odds ratio, OR = 5.1, 95% confidence interval, CI: 1.9–13.7; p = 0.00093). However, no significant association was seen for rs3077 with progressive CHB infection versus inactive HBsAg carrier status (OR = 2.7, 95% CI: 0.6–11.1; p = 0.31). In contrast, HLA-DPB1 rs9277535 was not associated with HBV infection in Caucasians (OR = 0.8, 95% CI: 0.4–1.9; p = 1).
Conclusions: A highly significant association of HLA-DPA1 rs3077 with HBV infection was observed in Caucasians. However, as a differentiation between different clinical courses of HBV infection was not possible, knowledge of the HLA-DPA1 genotype cannot be translated into personalized anti-HBV therapy approaches.
Adult human cardiac mesenchymal-like stromal cells (CStC) represent a relatively accessible cell type useful for therapy. In this light, their conversion into cardiovascular precursors represents a potential successful strategy for cardiac repair. The aim of the present work was to reprogram CStC into functionally competent cardiovascular precursors using epigenetically active small molecules. CStC were exposed to low serum (5% FBS) in the presence of 5 µM all-trans Retinoic Acid (ATRA), 5 µM Phenyl Butyrate (PB), and 200 µM diethylenetriamine/nitric oxide (DETA/NO), to create a novel epigenetically active cocktail (EpiC). Upon treatment the expression of markers typical of cardiac resident stem cells such as c-Kit and MDR-1 were up-regulated, together with the expression of a number of cardiovascular-associated genes including KDR, GATA6, Nkx2.5, GATA4, HCN4, NaV1.5, and α-MHC. In addition, profiling analysis revealed that a significant number of microRNA involved in cardiomyocyte biology and cell differentiation/proliferation, including miR 133a, 210 and 34a, were up-regulated. Remarkably, almost 45% of EpiC-treated cells exhibited a TTX-sensitive sodium current and, to a lower extent in a few cells, also the pacemaker If current. Mechanistically, the exposure to EpiC treatment introduced global histone modifications, characterized by increased levels of H3K4Me3 and H4K16Ac, as well as reduced H4K20Me3 and H3s10P, a pattern compatible with reduced proliferation and chromatin relaxation. Consistently, ChIP experiments performed with H3K4me3 or H3s10P histone modifications revealed the presence of a specific EpiC-dependent pattern in c-Kit, MDR-1, and Nkx2.5 promoter regions, possibly contributing to their modified expression. Taken together, these data indicate that CStC may be epigenetically reprogrammed to acquire molecular and biological properties associated with competent cardiovascular precursors.
One of the means of expressing emotional content is the naming of people. Many negative personal names are created using derivation (suffixes); the goal of this study is to determine which suffixes are frequently used and whether any German suffixes have primarily negative meanings.
A decade since the availability of Mycobacterium tuberculosis (Mtb) genome sequence, no promising drug has seen the light of the day. This not only indicates the challenges in discovering new drugs but also suggests a gap in our current understanding of Mtb biology. We attempt to bridge this gap by carrying out extensive re-annotation and constructing a systems level protein interaction map of Mtb with an objective of finding novel drug target candidates. Towards this, we synergized crowd sourcing and social networking methods through an initiative ‘Connect to Decode’ (C2D) to generate the first and largest manually curated interactome of Mtb termed ‘interactome pathway’ (IPW), encompassing a total of 1434 proteins connected through 2575 functional relationships. Interactions leading to gene regulation, signal transduction, metabolism, structural complex formation have been catalogued. In the process, we have functionally annotated 87% of the Mtb genome in context of gene products. We further combine IPW with STRING based network to report central proteins, which may be assessed as potential drug targets for development of drugs with least possible side effects. The fact that five of the 17 predicted drug targets are already experimentally validated either genetically or biochemically lends credence to our unique approach.
This article focuses on the roles of temporal adverbs in the linguistic expression of emotions. Emotions are phenomena which we experience subjectively, and which we are unable to grasp without respect to time. The intersubjective linguistic expression of emotions in the novel involves the use of temporal adverbs accompanying the narrative structure of the text and helping to intensify the expression of emotions.
In the title compound, [Ag(BF4)(C14H12N2O4)]n, the coordination of the Ag+ ion is trigonal–bipyramidal with the N atoms of two ethane-1,2-diyl bis(pyridine-3-carboxylate) ligands in the apical positions and three F atoms belonging to different tetrafluoridoborate anions in the equatorial plane. The material consists of infinite chains of [Ag(C14H12N2O4)] units running along [001], held together by BF4 − bridging anions.
Molecules of the title compound (alternative name: butane-1,4-diyl dinicotinate), C16H16N2O4, lie on a inversion centre, located at the mid-point of the central C—C bond of the aliphatic chain, giving one half-molecule per asymmetric unit. The butane chain adopts an all-trans conformation. The dihedral angle between the mean plane of the butane-3-carboxylate group [for the non-H atoms, maximum deviation = 0.0871 (15) Å] and the pyridine ring is 10.83 (7)°. In the crystal, molecules lie in planes parallel to (122). The structure features weak π–π interactions with a centroid–centroid distance of 3.9281 (11) Å.
This paper explores political engagement by Guatemalans who seasonally migrate to Canada as contracted agricultural workers. Since 2003, an ever-increasing number of Guatemalans have pursued economic opportunities in Canadian fields and greenhouses as participants in a labour migration scheme brokered by the International Organization for Migration (IOM) called the Temporary Agricultural Workers to Canada (TAWC) Project. While some describe this labour migration as a win-win situation for employers and migrant workers, for too many of these migrants, work in Canada has demanded sacrifices and losses, not the least of which of their human rights and dignity at the hands of employers and administrators of the TAWC Project. While there is a great deal at stake for these migrants should they denounce mistreatment, given the climate of fear created by the employer-driven nature of the TAWC project, a growing number of them have been pushed to do so. With the support of allies that encourage political empowerment of migrant workers, black-listed Guatemalans have formed a political advocacy group - Asociación de Guatemaltecos Unidos por Nuestros Derechos (AGUND) - aimed at fighting for the realization of their rights and redressing cases of wrongdoing. Based on workers’ testimonies and other institutional interviews, this paper outlines the difficulties workers have experienced as labour migrants to Canada, the context of vulnerability that largely impedes them from denouncing mistreatment, and the development and activities of AGUND. Informed by literature on political organizing, it also identifies the factors that have both impeded and encouraged political activity on the part of these disenfranchised yet determined Guatemalan workers.
The Přemyslid King Otakar II is one of the most prominent figures in Czech (and Central European) history. However, he is also a highly controversial figure, primarily due to his unflagging support for the German-speaking communities on his territory, which figures such as František Palacký considered to be excessive. The theme of German medieval colonization and Czech/German coexistence naturally appears in literary works dealing with Otakar's life. The Austrian dramatist Franz Grillparzer's play "König Ottokars Glück und Ende" is no exception. The topic of German colonization is relatively peripheral within the work, however the brief scene featuring the King and the burghers of Prague (who protest at Prague Castle against the expulsion of the Czechs and the settlement of Germans in their place) so incensed the Czech literary scene that the work has still not yet been translated into Czech. This article aims to analyze the scene in question, comparing Grillparzer's drama with the novel "Královský úděl" by the Czech author Nina Bonhardová.
Trockenrasen gehören in Sachsen-Anhalt zu den stark gefährdeten Biotoptypen, in gleichem Maße gilt diese Einschätzung für ihre Zoozönosen (Sacher & Platen 2004). Als Sonderstandorte stellen die Trockenrasen Refugien für stenotope und xerothermophile Tierarten dar. Ein beachtlicher Teil dieser Arten gehört zur einheimischen Spinnenfauna. Sacher (2001) wies auf den herausragenden faunistischen Wert der Trockenrasen im Elbetal hin. Isolierte Lage und geringe Größe beschleunigen allgemein bekannte Veränderungen infolge Nutzungsaufgabe oder -änderung, die in den letzten Jahrzehnten zum Verlust dieser Sonderstandorte führten. Für die Binnendüne bei Hohenwarthe wurde deshalb eine Arteninventur der dort vorhandenen Webspinnenzönose mit dem Ziel vorgenommen, die Besonderheit dieser Düne herauszustellen und den Gefährdungsgrad der nachgewiesenen Arten zu ermitteln. Die Ergebnisse und Schlussfolgerungen dieser sich über mehrere Jahre erstreckenden Erfassung sollen als Handlungsempfehlung in die FFH-Managementpläne des Gebietes aufgenommen werden. Dieser Beitrag stellt Zwischenergebnisse vor, die zoologische Bearbeitung weiterer Binnendünenstandorte im Biosphärenreservat Mittelelbe wird fortgesetzt.
Für das Gebiet zwischen Weißer Elster und Wethau, dem östlichen Teil des Burgenlandkreises im Süden Sachsen-Anhalts, sind 20 Farnarten im Zeitraum von 130 Jahren belegt. Der Fundort des Königs-Rispenfarns (Osmunda regalis) im Gebiet der Heideteiche bei Osterfeld ist erloschen. Zwei landesweit gefährdete Arten zeigen im Nordosten des Bearbeitungsgebietes, in der Bergbaufolgelandschaft zwischen Deuben und Westsachsen, eine positive Bestandsentwicklung: Mondrautenfarn (Botrychium lunaria) und Natternzungenfarn (Ophioglossum vulgatum) sind gegenwärtig aufgrund der Neubesiedlung verkippter Rohböden stellenweise sogar häufig.
Membrane-embedded β-barrel proteins are found in the outer membranes (OM) of Gram-negative bacteria, mitochondria and chloroplasts. In eukaryotic cells, precursors of these proteins are synthesized in the cytosol and have to be sorted to their corresponding organelle. Currently, the signal that ensures their specific targeting to either mitochondria or chloroplasts is ill-defined. To address this issue, we studied targeting of the chloroplast β-barrel proteins Oep37 and Oep24. We found that both proteins can be integrated in vitro into isolated plant mitochondria. Furthermore, upon their expression in yeast cells Oep37 and Oep24 were exclusively located in the mitochondrial OM. Oep37 partially complemented the growth phenotype of yeast cells lacking Porin, the general metabolite transporter of this membrane. Similarly to mitochondrial β-barrel proteins, Oep37 and Oep24 expressed in yeast cells were assembled into the mitochondrial OM in a pathway dependent on the TOM and TOB complexes. Taken together, this study demonstrates that the central mitochondrial components that mediate the import of yeast β-barrel proteins can deal with precursors of chloroplast β-barrel proteins. This implies that the mitochondrial import machinery does not recognize signals that are unique to mitochondrial β-barrel proteins. Our results further suggest that dedicated targeting factors had to evolve in plant cells to prevent mis-sorting of chloroplast β-barrel proteins to mitochondria.
Ricarda Huchs "Geschichten von Garibaldi" nehmen einen einmaligen Rang in der Italienliteratur deutscher Schriftstellerinnen ein. Der erste Band, um den es in diesem Aufsatz vorwiegend gehen soll, zeigt die 'ewige Stadt' aus einem zumindest in der deutschen Literatur sonst kaum gewählten Blickwinkel. Es geht um das revolutionäre Rom, um Rom als Schauplatz der 1848/49er Republik. Rom ist also nicht wie sonst Antike-Freiluftmuseum, idyllischer Ort künstlerischer Selbsterfahrung oder religiöser Heimkehr, sondern politischer Zankapfel, eine Stadt, wegen der gekämpft und gestorben wird und um die es zu kämpfen und zu sterben lohnt. "Die Verteidigung Roms", der erste Band der Geschichten von Garibaldi, ist ein Roman über Politik, gar über aufrührerische und sich gelegentlich als revolutionär verstehende Politik, und er zeigt Rom als Schlachtfeld, als Schauplatz eines internationalen Befreiungskampfes.