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Ventriculoperitoneal shunts equipped with a reservoir and a valve to manually switch off the shunt function can be used for intraventricular injections of therapeutics in patients suffering from a communicating hydrocephalus caused by leptomeningeal metastases. These shunt devices avoid the risk of injecting therapeutics through the distal leg of the shunt system into the intraperitoneal space, which may cause toxicity. Furthermore, regular intraventricular injections of chemotherapeutics help to maintain sufficient concentrations in the ventricular space. Therefore, ventriculoperitoneal shunts equipped with an on-off valve are a useful tool to reliably inject chemotherapeutics into the ventricles. In order to systematically assess feasibility, safety, and efficacy of this procedure, we performed a retrospective analysis of all patients with leptomeningeal metastases who had received a shunt system at our institution. In total, six adult patients had a ventriculoperitoneal shunt equipped with an on-off valve implanted. Out of these six patients, two patients subsequently received intraventricular injections of chemotherapeutics. The configuration of the valve setting and the intraventricular injections were easily feasible in the setting of a neuro-oncology department. The complication of a shunt leakage occurred in one patient following the first intraventricular injection. No extra-central nervous system (CNS) toxicities were observed. In summary, ventriculoperitoneal shunts with on-off valves are useful tools for reliable intraventricular administration of therapeutics.
Artificial intelligence (AI)1, together with big data, is the driving force behind the ever-accelerating digital revolution. AI has what it takes to call into question our fundamental concepts and processes of political, social, economic etc. order (Macron, 2018; Zuboff, 2018), and the law will not be spared. Therefore, all societal actors (inter alia from politics, the economy, legal practice and academia) must take responsibility for the crucial twin tasks of determining the right, balanced relationship between AI and the law, and even to hybridise them. ...
Background: No observational studies have evaluated the "real-world" effectiveness of dual bronchodilation comprising a long-acting β2-agonist plus a long-acting muscarinic antagonist vs that of triple therapy (long-acting β2-agonist plus long-acting muscarinic antagonist plus inhaled corticosteroid) in COPD.
Materials and methods: DACCORD is a non-interventional, observational clinical study that recruited patients following COPD maintenance therapy initiation or change in maintenance therapy between or within therapeutic class. Given the non-interventional nature of the study, the decision to initiate or change medication had to be made by the patients’ physicians prior to inclusion in DACCORD. We used a matched-pairs analysis to compare disease progression in two patient groups: those receiving dual bronchodilation vs those receiving triple therapy (each group n=1,046).
Results: In two subgroups of patients matched according to a broad range of demographic and disease characteristics, over 1 year, fewer patients receiving dual bronchodilation exacerbated than those receiving triple therapy (15.5% vs 26.6%; P<0.001), with a greater improvement from baseline in COPD Assessment Test total score at 1 year (mean±SD -2.9±5.8 vs -1.4±5.5; P<0.001). When analyzed according to prior therapy, the highest rate of exacerbations was in patients on triple therapy prior to the study who remained on triple therapy. Those changing from mono-bronchodilator to dual bronchodilation had the greatest COPD Assessment Test total score improvement.
Conclusion: In this "real-life" cohort of patients with COPD, most of whom had not exacerbated in the 6 months prior to entry, triple therapy did not seem to improve outcomes compared with dual bronchodilation in terms of either exacerbations or health status. Our analyses clearly demonstrate the potential impact of prior medication on study results, something that should be taken into account when interpreting the results even of controlled clinical trials.
Staatliches Hacking von Computern und Smartphones hat Konjunktur. Durch das Gesetz zur effektiveren und praxistauglicheren Ausgestaltung des Strafverfahrens vom 17. August 2017 (BGBl. I S. 3202) wurden Online-Durchsuchung und Quellen-TKÜ mittels "Staatstrojanern" zu Standardmaßnahmen im strafrechtlichen Ermittlungsverfahren. Die StPO erlaubt seither den Einsatz von Staatstrojanern in mehreren zehntausend Fällen im Jahr: Sie sind nun immer dann zulässig, wenn bisher eine klassische Telekommunikationsüberwachung gem. § 100a Abs. 1 StPO unter Einbindung der jeweiligen Provider (vgl. § 100b StPO a.F.) vorgenommen wurde.
Background: Treatment complexity rises in line with the number of drugs, single doses, and administration methods, thereby threatening patient adherence. Patients with multimorbidity often need flexible, individualised treatment regimens, but alterations during the course of treatment may further increase complexity. The objective of our study was to explore medication changes in older patients with multimorbidity and polypharmacy in general practice.
Methods: We retrospectively analysed data from the cluster-randomised PRIMUM trial (PRIoritisation of MUltimedication in Multimorbidity) conducted in 72 general practices. We developed an algorithm for active pharmaceutical ingredients (API), strength, dosage, and administration method to assess changes in physician-reported medication data during two intervals (baseline to six-months: ∆1; six- to nine-months: ∆2), analysed them descriptively at prescription and patient levels, and checked for intervention effects.
Results: Of 502 patients (median age 72 years, 52% female), 464 completed the study. Changes occurred in 98.6% of patients (changes were 19% more likely in the intervention group): API changes during ∆1 and ∆2 occurred in 414 (82.5%) and 338 (67.3%) of patients, dosage alterations in 372 (74.1%) and 296 (59.2%), and changes in API strength in 158 (31.5%) and 138 (27.5%) respectively. Administration method changed in 79 (16%) of patients in both ∆1 and ∆2. Simvastatin, metformin and aspirin were most frequently subject to alterations.
Conclusion: Medication regimens in older patients with multimorbidity and polypharmacy changed frequently. These are mostly due to discontinuations and dosage alterations, followed by additions and restarts. These findings cast doubt on the effectiveness of cross-sectional assessments of medication and support longitudinal assessments where possible.
Trial registration: 1. Prospective registration: Trial registration number: NCT01171339; Name of registry: ClinicalTrials.gov; Date of registration: July 27, 2010; Date of enrolment of the first participant to the trial: August 12, 2010.
2. Peer reviewed trial registration: Trial registration number: ISRCTN99526053; Name of registry: Controlled Trials; Date of registration: August 31, 2010; Date of enrolment of the first participant to the trial: August 12, 2010.
Im Beitrag wird die Frage des korporativen Gedächtnisses erörtert, wie es sich 1949–1951 in betriebsinternen Zeitschriften als Basis für eine neue korporative Identität der volkseigenen Textilunternehmen gestaltete. Hierbei wird besonders mit den betriebsinternen, von Arbeiter/innen oder den Gewerkschaften verfassten Zeitschriften "Naše pětiletka" (Unser Fünfjahresplan) des Vlnap-Konzerns und "Mosilana píše" (Mosilana schreibt) des Mosilana-Konzerns gearbeitet. Der Schwerpunkt der Untersuchung liegt auf dem Umgang dieser Zeitschriften mit ihrer korporativen Vergangenheit bzw. mit der Vergangenheit der tschechoslowakischen Textilbranche generell. Trotz der schon 1949 dominierenden Ideologisierung des korporativen Gedächtnisses im Sinne des kommunistischen Regimes zeigen sich vor allem in der Auseinandersetzung darüber, welche Art von Kritik in den neuen Konzernen wünschenswert wäre, durchaus auch nicht machtkonforme Kontinuitäten mit der kapitalistischen Ära. Diese verflüchtigen sich jedoch spätestens im Laufe des Jahres 1951.
This scientific article focuses on Ursula Ackrill’s novel ˮZeiden, im Januarˮ and its aim is to examine the specificity of present-day literature of the Transylvanian Saxons. Starting from the methodological considerations of Jan Assmann and Aleida Assmann, the concept of memorial culture will be exemplified and analyzed through relevant scenes of the novel, in close connection with Leontina Philippi’s approach of writing the chronicle of Codlea. Antonescu’s fascist dictatorship, the obligation for Saxon men to serve in the SS troops, the friendly collaboration between Antonescu and Hitler, the collaboration between German and Saxon military, the role of collaborators at that time, the Saxons’ customs and traditions, the portrait of the Jew of Lipscani street, Bucharest society during the rule of Ion Antonescu are just a few aspects of the novel which emphasize the intercultural character of this writing on the basis of communicative and cultural memory.
Besides some well-established forms like autoritär 'authoritarian'; humanitär 'humanitarian'; new coinages ending with -itär can be found in German. These adjectives are closely related to nouns ending with -ität. From an etymological point of view; these formations are morphologically transparent. Not only are the adjectives new; but -itär emerges as a new suffix.
Intestinal graft-versus-host disease (GvHD) is a life-threatening, inflammatory donor T cell-mediated complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the light of the reported efficacy of interleukin-23 (IL-23)-blockade to mitigate syngeneic intestinal inflammation in inflammatory bowel disease patients, targeting IL-23 and thereby interleukin-17a (IL-17a) producing T helper (Th17) cells as the T cell subset assumed to be mostly regulated by IL-23, has emerged as a putatively general concept to harness immune-mediated mucosal inflammation irrespective of the underlying trigger. However, the role of Th17 cells during allo-response driven colitis remains ambiguous due to a series of studies with inconclusive results. Interestingly, we recently identified granulocyte-macrophage colony-stimulating factor (GM-CSF+) T cells to be promoted by interleukin-7 (IL-7) signaling and controlled by the activating protein-1 transcription factor family member basic leucine zipper transcription factor ATF-like (BATF) as critical mediators of intestinal GvHD in mice. Given the dual role of BATF, the contribution of IL-23-mediated signaling within donor T cells and bona fide Th17 cells remains to be delineated from the regulation of GM-CSF+ T cells in the absence of BATF. Here, we found in a complete MHC class I-mismatched model that genetic inactivation of the IL-23 receptor (IL-23R) or the transcription factor retinoic acid-related orphan receptor gamma t (RORγt) within donor T cells similarly ablated Th17 cell formation in vivo but preserved the T cells’ ability to induce intestinal GvHD in a compared to wild-type controls indistinguishable manner. Importantly, RORγt-independent manifestation of intestinal GvHD was completely dependent on BATF-regulated GM-CSF+ T cells as BATF/RORγt double-deficient T cells failed to induce colitis and the antibody-mediated blockage of IL-7/IL-7R interaction and GM-CSF significantly diminished signs of intestinal GvHD elicited by RORγt-deficient donor T cells. Finally, in analogy to our murine studies, colonic RORC expression levels inversely correlated with the presence of GvHD in allo-HSCT patients. Together, this study provides a crucial example of a BATF-dependent, however, IL-23R signaling- and RORγt-, i.e., Th17 fate-independent regulation of a colitogenic T cell population critically impacting the current understanding of intestinal GvHD.
Das Kleine Schneeglöckchen (Galanthus nivalis) zählt zu den klassischen Frühjahrsgeophyten, wobei die Bezeichnung Wintergeophyt an dieser Stelle viel treffender wäre, denn die Art gehört neben dem Winterling (Eranthis hyemalis) bei uns zu den allerersten blühenden Pflanzen im Jahr. Ihre Blüten erscheinen massenhaft zwischen Januar und März, in milden Jahren blühen einzelne Pflanzen auch schon im Dezember. Somit kommt dem Schneeglöckchen nicht nur unter Botanikern eine symbolische Bedeutung zu: Sein Erscheinen versinnbildlicht das allmähliche Erwachen der Natur nach der Winterruhe und den Neubeginn des Pflanzenjahres.
Die USA - Terra incognita für die meisten Europäer im frühen und mittleren 19. Jahrhundert - spielten als Modell staatswissenschaftlichen, verfassungsrechtlichen und politischen Denkens bei den Vertretern und Verteidigern der monarchischen Herrschaft und ihres Machtgefüges genauso wie bei den Anführern und Anhängern gemäßigter und radikaler Reform-, Oppositions- und Widerstandsbewegungen, aber auch an deutschen Universitäten und Akademien, in literarischen und philosophischen Zirkeln, in Unternehmer- und Verlegerkreisen, Künstlerbünden und der medialen Öffentlichkeit eine zentrale Rolle. Zugleich stellte die Neue Welt ein Sehnsuchtsziel für Freiheitsliebende, politische Flüchtlinge, Auswanderungswillige und Wirtschaftsmigranten, aber auch bisweilen die gefürchtete Endstation für verbannte Gefangene dar: Das Spektrum der Funktionen, Aufgaben, Bilder und Vorstellungen ist breit, das die Vereinigten Staaten von Amerika in der Wahrnehmung der Zeitgenossen im Vor- und Nachmärz einnahmen und das ihnen zugeschrieben wurde - nicht zuletzt auch in der (Emigrations-)Literatur. Gerade die repressive, restaurative Politik in Europa und hier vor allem in den Einzelstaaten des Deutschen Bundes bildete für viele unter Verfolgungsmaßnahmen und Zensurbedingungen arbeitende und leidende Oppositionelle, Intellektuelle, Gelehrte und Kulturschaffende den Ausgangspunkt für ihre intensive Auseinandersetzung mit dem Verfassungs-, Regierungs- und Gesellschaftssystem der USA und den dort, wie es scheint, ohne Probleme vertretenen und verwirklichten Ideen von Freiheit, Demokratie, Recht, Föderalismus, Republik und Revolution und inspirierten sie gleichzeitig zu einer umfassenden künstlerischen und wissenschaftlichen Beschäftigung mit den jenseits des Atlantiks vorgefundenen und noch näher zu erkundenden Kulturen, Sprachen und Landschaften.
Background: To study the expression pattern, localisation and potential clinical significance of aquaporin water channels (AQP) both in prostate cancer (PC) cell lines and in benign and malignant human prostate tissue.
Methods: The AQP transcript and protein expression of HPrEC, LNCaP, DU-145 and PC3 cell lines was investigated using reverse transcriptase polymerase chain reaction (RT-PCR) and immunofluorescence (IF) microscopy labelling. Immunohistochemistry (IHC) was performed to assess AQP protein expression in surgical specimens of benign prostatic hyperplasia as well as in PC. Tissue mRNA expression of AQPs was quantified by single-step reverse transcriptase quantitative polymerase chain reaction (qPCR). Relative gene expression was determined using the 40-ΔCT method and correlated to clinicopathological parameters.
Results: Transcripts of AQP 1, 3, 4, 7, 8, 10 and 11 were expressed in all four cell lines, while AQP 9 transcripts were not detected in malignant cell lines. IF microscopy confirmed AQP 3, 4, 5, 7 and 9 protein expression. IHC revealed highly heterogeneous AQP 3 protein expression in PC specimens, with a marked decrease in expression in tumours of increasing malignancy. Loss of AQP 9 was shown in PC specimens. mRNA expression of AQP3 was found to be negatively correlated to PSA levels (ρ = − 0.354; p = 0.013), D’Amico risk stratification (ρ = − 0.336; p = 0.012), ISUP grade (ρ = − 0.321; p = 0.017) and Gleason score (ρ = − 0.342; p = 0.011).
Conclusions: This is the first study to systematically characterize human prostate cell lines, benign prostatic hyperplasia and PC in relation to all 13 members of the AQP family. Our results indicate the differential expression of several AQPs in benign and malignant prostate tissue. A significant correlation was observed between AQP 3 expression and tumour grade, with progressive loss in more malignant tumours. Taken together, AQPs may play a role in the progression of PC and AQP expression patterns may serve as a prognostic marker.
The article presents an analysis of the development of labour market risks in Germany in light of changing working poverty risks. Low hourly wages and part-time employment are identified as the main demand-side-related mechanisms for household poverty. Their measurement and development are discussed as well as their contribution to trends in working poverty risks. A rise in low wages, especially among part-time employed households, was decisive for the increase in working poverty risks in Germany by 45% between the end of the 1990s and the end of the 2000s. We therefore study these trends more closely in the multivariate analysis. The results show that while low wages are unequally distributed across occupations and industries, shifts in employment between sectors explain only a minor part of the change in low wages. However, they reveal a polarization of low-wage risks by skill-level and sector of employment, on the one hand, and full-time and part-time employees, on the other hand.
Artificial Intelligence (AI) will be one of the key technologies driving the future competitiveness of numerous industries. However, the term "AI" is defined in a variety of ways. AI could be understood as an umbrella term for technologies and systems that carry out tasks otherwise only executable with human intelligence. This requires specific skills that fall into the broad categories of "Sense", "Comprehend", "Act" and "Learn". Through machine learning, modern AI systems can be trained to adapt to changes in their environment, self-optimise and hence achieve better results than earlier versions of AI systems that were based on clearly defined, pre-programmed rules. Based on AI methods, rational and autonomous agents can be developed that collect and analyse relevant information from their environments, come to optimal conclusions based on certain performance parameters and eventually perform physical actions (e.g. robotics) or virtual actions (e.g. chat bots). Machine learning algorithms ensure that the information base of the system is continuously updated so that performance of the system is optimised in an iterative process.
With a notional amount outstanding of more than USD 500 trillion, the market for OTC derivatives is of vital importance for global financial stability. A growing proportion of these contracts are cleared via central counterparties (CCPs), which means that CCPs are gaining in importance as critical financial market infrastructures. At the same time, there is growing concern that a new "too big to fail" problem could arise, as the CCP industry is highly concentrated due to economies of scale. From a European perspective, it should be noted that the clearing of euro-denominated OTC derivatives mainly takes place in London, hence outside the EU in the foreseeable future. For some time there has been a controversial discussion as to whether this can remain the case post Brexit.
CCPs, which clear a significant proportion of euro OTC derivatives and are systemically relevant from an EU perspective, should be subject to direct supervision by EU authorities and should be established in the EU. This would represent an important building block for a future Capital Markets Union in Europe, as regulatory or supervisory arbitrage in favour of systemically important third- ountry CCPs could be prevented. In addition, if a systemically relevant CCP handling a considerable portion of the euro OTC derivatives business were to run into serious difficulties, this may impact ECB monetary policy. This applies both to demand for central bank money and to the transmission of monetary policy measures, which can be significantly impaired, particularly in the event that the repo market or payment systems are disrupted. It is therefore essential for the ECB to be closely involved in the supervision of CCPs. Against this background, the draft amendment of EMIR (European Market Infrastructure Regulation) presented on 13 June 2017 is a step in the right direction. In addition, there is an urgent need to introduce a recovery and resolution mechanism for CCPs in the EU to complement the existing single resolution mechanism (SRM) for banks in the eurozone. Only then can the diverse interdependencies between banks and CCPs be adequately taken into account in the recovery and resolution programmes required in a financial crisis.
The German government has recently adopted a reform package for the statutory pension insurance scheme to ensure that the pension level will not fall below 48% and that the contribution rate will not exceed 20% up to 2025. In addition, there are planned improvements in maternal pensions, pensions for people with reduced earnings capacity and relief for low-income earners. The total extra cost of these measures is estimated at approximately EUR 32bn, to be financed by funds of the statutory pension system and by increased federal subsidies. It is currently unclear how the German pay-as-you-go pension system will be reformed for the period after 2025. The author suggests establishing a “Pension Fund Germany” as a capital-backed fund with a highly diversified investment portfolio. A German sovereign wealth fund of this kind could make an important contribution to greater intergenerational equity. Financing could be provided by, for example, retaining part of the solidarity surcharge on German income tax rather than abolishing it entirely, as is currently envisaged.
With a notional amount outstanding of more than USD 500 trillion, the market for OTC derivatives is of vital importance for global financial stability. A growing proportion of these contracts are cleared via central counterparties (CCPs), which means that CCPs are gaining in importance as critical financial market infrastructures. At the same time, there is growing concern that a new „too big to fail" problem could arise, as the CCP industry is highly concentrated due to economies of scale. From a European perspective, it should be noted that the clearing of euro-denominated OTC derivatives mainly takes place in London, hence outside the EU in the foreseeable future. For some time there has been a controversial discussion as to whether this can remain the case post Brexit. CCPs, which clear a significant proportion of euro OTC derivatives and are systemically relevant from an EU perspective, should be subject to direct supervision by EU authorities and should be established in the EU. This would represent an important building block for a future Capital Markets Union in Europe, as regulatory or supervisory arbitrage in favour of systemically important third-country CCPs could be prevented. In addition, if a systemically relevant CCP handling a considerable portion of the euro OTC derivatives business were to run into serious difficulties, this may impact ECB monetary policy. This applies both to demand for central bank money and to the transmission of monetary policy measures, which can be significantly impaired, particularly in the event that the repo market or payment systems are disrupted. It is therefore essential for the ECB to be closely involved in the supervision of CCPs. Against this background, the draft amendment of EMIR (European Market Infrastructure Regulation) presented on 13 June 2017 is a step in the right direction. In addition, there is an urgent need to introduce a recovery and resolution mechanism for CCPs in the EU to complement the existing single resolution mechanism (SRM) for banks in the eurozone. Only then can the diverse interdependencies between banks and CCPs be adequately taken into account in the recovery and resolution programmes required in a financial crisis.
Human papilloma virus (HPV) infection is linked to cervical cancer, which represents the world's fourth most common cancer in women. So far, no detailed map of the worldwide HPV research architecture has been constructed. Hence, this study focuses on the chronological development and geographical distribution of the global HPV-specific publications and evaluates citation-based parameters as well as socioeconomic features of the publishing countries.
In total, 29,330 HPV-related publications were identified. The US was the leading country with 12,270 publications. Only high-income-countries were found in the ranking of the fifteen most active countries with Germany, France, and Japan among the top five. Analysis of HPV research activity in relation to the economic strength demonstrated a lead position of Finland and Sweden with an average of 2248.78 and 1924.67 HPV-related publications per GDP in 1000 bn US-$, respectively. The most active upper-middle-income country was Mexico (416.78 HPV-related publications per GDP in 1000 bn US-$). India as lower-middle-income country reached a value of 279.78 HPV-related publications per GDP in 1000 bn US-$. Collaboration analysis pointed to the US as the center of the 4517 international HPV collaborations.
The worldwide HPV-research landscape is dominated by North American and Western European countries. By contrast, a high prevalence of HPV-related cervical cancer is documented for low-income countries. Hence, HPV-related public health interventions and prevention research specifically tailored to these countries needs to be fostered by monetary support and international collaborations.
Background: Despite the numerous associations of vitamin D with health and disease, vitamin D deficiency is still common from a global perspective. While basic research, clinical and preventive activities grow constantly in vitamin D research, there is no in-depth analysis of the related global scientific productivity available so far.
Methods: Density equalizing mapping procedures (DEMP) were combined with socioeconomic benchmarks using the NewQIS platform.
Results: A total of 25,992 vitamin D-related research articles were identified between 1900 to 2014 with a significant increase (r2 = .6541) from 1900 to 2014. Authors located in Northern America – especially in the USA – distributed the majority of global vitamin D research, followed by their Western European counterparts. DEMP-analysis illustrates that Africa and South America exhibit only minor scientific productivity. Among high-income group countries, Scandinavian nations such as Denmark or Finland (2147.9 and 1607.7 vitamin D articles per GDP in 1000 billion USD) were highly active with regard to socioeconomic figures.
Conclusion: Networks dedicated to vitamin D research are present around the world. Overall, the Northern American and Western European nations occupy prominent positions. However, South American, African and Asian countries apart from Japan only play a minor role in the global research production related to vitamin D. Since vitamin D deficiency is currently increasing in the Americas, Europe and parts of the Middle East, research in these regions may need to be encouraged.
IN THE CURRENT REGIME OF LOW INTEREST RATES, TAKING SOUND SAVINGS DECISIONS POSES A SIGNIFICANT CHALLENGE TO MOST INDIVIDUALS. FUND SAVINGS PLANS ALLOW TO ACCUMULATE PRIVATE SAVINGS VIA AUTOMATED RECURRING INVESTMENTS IN SELECTED FUNDS. LOW FEES AND SMALL MINIMUM INVESTMENT AMOUNTS MAKE THEM A SUITABLE SAVINGS VEHICLE ALSO FOR LOW NET-WORTH INDIVIDUALS. WHILE TRADITIONAL FINANCIAL ADVISORS ONLY RELUCTANTLY PROVIDE ADVICE ON SMALL-SCALE INVESTMENTS, THE RECENT SURGE OF ROBO-ADVISORS ENABLES ACCESS TO ADVICE ON SAVINGS PLAN CHOICES FOR INVESTORS FROM ALL WEALTH BANDS. IN THIS REPORT, WE PRESENT EMPIRICAL RESULTS ON THE IMPACT OF INTRODUCING AN AUTOMATED INVESTMENT TOOL AT A LARGE GERMAN ONLINE BANK ON PRIVATE INVESTORS’ SAVINGS DECISIONS.
The interaction between the T4 bacteriophage gp37 adhesin and the bacterial lipopolysaccharide (LPS) is a well-studied system, however, the affinity and strength of the interaction haven’t been analyzed so far. Here, we use atomic force microscopy to determine the strength of the interaction between the adhesin and its receptor, namely LPS taken from a wild strain of E. coli B. As negative controls we used LPSs of E. coli O111:B and Hafnia alvei. To study the interaction an AFM tip modified with the gp37 adhesin was used to scan surfaces of mica covered with one of the three different LPSs. Using the correlation between the surface topography images and the tip-surface interaction we could verify the binding between the specific LPS and the tip in contrast to the very weak interaction between the tip and the non-binding LPSs. Using force spectroscopy we could then measure the binding strength by pulling on the AFM tip until it lifted off from the surface. The force necessary to break the interaction between gp37 and LPS from E. coli B, LPS from E. coli O111:B and LPS from H. alvei were measured to be 70 ± 29 pN, 46 ± 13 pN and 45 ± 14 pN, respectively. The latter values are likely partially due to non-specific interaction between the gp37 and the solid surface, as LPS from E. coli O111:B and LPS from H. alvei have been shown to not bind to gp37, which is confirmed by the low correlation between binding and topography for these samples.
Dysregulation of blood sphingolipids is an emerging topic in clinical science. The objective of this study was to determine preanalytical biases that typically occur in clinical and translational studies and that influence measured blood sphingolipid levels. Therefore, we collected blood samples from four healthy male volunteers to investigate the effect of storage conditions (time, temperature, long-term storage, freeze–thaw cycles), blood drawing (venous or arterial sampling, prolonged venous compression), and sample preparation (centrifugation, freezing) on sphingolipid levels measured by LC-MS/MS. Our data show that sphingosine 1-phosphate (S1P) and sphinganine 1-phosphate (SA1P) were upregulated in whole blood samples in a time- and temperature-dependent manner. Increased centrifugation at higher speeds led to lower amounts of S1P and SA1P. All other preanalytical biases did not significantly alter the amounts of S1P and SA1P. Further, in almost all settings, we did not detect differences in (dihydro)ceramide levels. In summary, besides time-, temperature-, and centrifugation-dependent changes in S1P and SA1P levels, sphingolipids in blood remained stable under practically relevant preanalytical conditions.
Die weltweiten Proteste von 1968 waren in verschiedenen Ländern unterschiedlich ausgeprägt. Geeint wurden sie durch einen Gesellschaftsentwurf, der sich nicht nur vom Kapitalismus unterschied, sondern auch vom Kommunismus und den Leitideen der Sozialdemokratie. Zu den wichtigsten Exponenten in Europa zählen Daniel Cohn-Bendit, Tariq Ali und Rudi Dutschke, die die Massen mobilisierten.
We will discuss the issue of Landau levels of quarks in lattice QCD in an external magnetic field. We will show that in the two-dimensional case the lowest Landau level can be identified unambiguously even if the strong interactions are turned on. Starting from this observation, we will then show how one can define a “plowest Landau level” in the four-dimensional case, and discuss how much of the observed effects of a magnetic field can be explained in terms of it. Our results can be used to test the validity of low-energy models of QCD that make use of the lowest-Landau-level approximation.
Python for Power System Analysis (PyPSA) is a free software toolbox for simulating and optimising modern electrical power systems over multiple periods. PyPSA includes models for conventional generators with unit commitment, variable renewable generation, storage units, coupling to other energy sectors, and mixed alternating and direct current networks. It is designed to be easily extensible and to scale well with large networks and long time series. In this paper the basic functionality of PyPSA is described, including the formulation of the full power flow equations and the multi-period optimisation of operation and investment with linear power flow equations. PyPSA is positioned in the existing free software landscape as a bridge between traditional power flow analysis tools for steady-state analysis and full multi-period energy system models. The functionality is demonstrated on two open datasets of the transmission system in Germany (based on SciGRID) and Europe (based on GridKit).
We present an experiment which tests children’s comprehension of the requirements of use of pronouns and definites. An adult-like use of definites and pronouns imposes different but related requirements. In the case of definites, a unique referent is required in the context, whereas in the case of a pronoun, the referent in the context has to be salient. In this experiment, we use a novel word task to test three-year-olds’ sensitivity to these requirements. Our results show that children are adult-like in their sensitivity to salience in their comprehension of pronouns, compared to definites. However, they failed to show sensitivity to the uniqueness requirement on the use of definites.
Die Frankfurter Dreikönigskirche steht auf dem Präsentierteller! Ohne umliegende Bebauung ist das evangelische Gotteshaus den Blicken der Vorbeikommenden schutzlos ausgeliefert. Nur eine kleine Baumgruppe verdeckt das Bauwerk ein wenig. Dieser weitestgehend freie Blick auf die Kirche hätte schon in der ersten Hälfte des 20. Jahrhunderts Wohnhäusern weichen sollen, wie ein erstmals 1915 und schließlich 1927 erneut ausgelobter Ideenwettbewerb beweist, dessen Siegerentwurf aber nie zur Ausführung gelangte und heute fast in Vergessenheit geraten ist. ...
Este trabalho tenciona fazer uma análise a respeito das contribuições de Axel Honneth no que concerne às suas contribuições para o debate sobre teorias da justiça no contexto atual. Neste sentido, pode ser elencada como principal a tentativa de alcançar princípios normativos pautados na horizontalidade, ou seja, na própria realidade social. Para alcançar êxito nesta empreitada reflexivo-filosófica, parte-se de suas obras A textura da justiça: sobre os limites do procedimentalismo contemporâneo e O direito da Liberdade, nos quais se tem a questão relacionada à liberdade, sendo esta tomada como o princípio de maior valor na contemporaneidade. Daí, a liberdade direcionada ao aspecto social ser especificamente expressa nas instituições, bem como seu vínculo estar intrinsecamente ligado às relações sociais, de mercado e também ao universo político. Ao se pressupor a existência de um vazio entre os princípios normativos pertencentes à justiça e a realidade social, conforme considera o autor, fomenta-se, a partir deste estudo, notar as potencialidades, bem como os limites desta reconstrução normativa, conforme proposição teórica de Honneth.
Convection-permitting models (CPMs) have proven their usefulness in representing precipitation on a sub-daily scale. However, investigations on sub-hourly scales are still lacking, even though these are the scales for which showers exhibit the most variability. A Lagrangian approach is implemented here to evaluate the representation of showers in a CPM, using the limited-area climate model COSMO-CLM. This approach consists of tracking 5‑min precipitation fields to retrieve different features of showers (e.g., temporal pattern, horizontal speed, lifetime). In total, 312 cases are simulated at a resolution of 0.01 ° over Central Germany, and among these cases, 78 are evaluated against a radar dataset. The model is able to represent most observed features for different types of convective cells. In addition, the CPM reproduced well the observed relationship between the precipitation characteristics and temperature indicating that the COSMO-CLM model is sophisticated enough to represent the climatological features of showers.
The Education Against Tobacco (EAT) network delivers smoking prevention advice in secondary schools, typically using the mirroring approach (i.e., a "selfie" altered with a face-aging app and shared with a class). In November 2017, however, the German assembly of EAT opted to expand its remit to include nursing students. To assess the transferability of the existing approach, we implemented it with the self-developed face-aging app "Smokerface" (=mixed − methods approach) in six nursing schools. Anonymous questionnaires were used to assess the perceptions of 197 students (age 18–40 years; 83.8% female; 26.4% smokers; 23.3% daily smokers) collecting qualitative and quantitative data for our cross-sectional study. Most students perceived the intervention to be fun (73.3%), but a minority disagreed that their own animated selfie (25.9%) or the reaction of their peers (29.5%) had motivated them to stop smoking. The impact on motivation not to smoke was considerably lower than experienced with seventh graders (63.2% vs. 42.0%; notably, more smokers also disagreed (45.1%) than agreed (23.5%) with this statement. Agreement rates on the motivation not to smoke item were higher in females than in males and in year 2–3 than in year 1 students. Potential improvements included greater focus on pathology (29%) and discussing external factors (26%). Overall, the intervention seemed to be appealing for nursing students
In den hessischen Mittelgebirgen wurden in der späten Bronzezeit erste befestigte Höhensiedlungen errichtet. Während für diese Zeit in den benachbarten fruchtbaren Beckenlagen eine intensive landwirtschaftliche Nutzung belegt ist, wissen wir über die Nutzungssysteme sowie die Entnahme von Ressourcen in den Mittelgebirgen noch vergleichsweise wenig. Im Rahmen des LOEWE-Projektes „Bronzezeitliche Burgen zwischen Taunus und Karpaten“ werden mit Hilfe archäobotanischer Analysen die Art und Intensität der Nutzung, mögliche Auswirkungen durch die Befestigungen auf die Vegetation der Umgebung sowie ihr Verhältnis zu den zentralen Altsiedellandschaften untersucht. Die pollenanalytischen Arbeiten konzentrieren sich auf den Taunus, den Raum Fulda und die Rhön. Erste Ergebnisse zeigen dort im ausgehenden 2. und beginnenden 1. Jt. v. Chr. eine deutliche Veränderung der Vegetation, die sich insbesondere durch einen raschen Wandel der von linden- zu buchendominierten Wäldern auszeichnet. Inwieweit der Bau der befestigten Höhensiedlungen in der späten Bronzezeit für die großen waldgeschichtlichen Umbrüche mit verantwortlich war oder eher als Reaktion darauf zu verstehen ist, soll im Zuge der weiteren Untersuchungen geklärt werden.
Das Buch Phonetik, Phonologie und Schrift von Silvia Dahmen und Constanze Weth ist in der Reihe LiLA - Linguistik fürs Lehramt im UTB-Verlag im Dezember 2017 erschienen. Die von Petra Gretsch und Gabriele Kniffka herausgegebene Reihe richtet sich an Lehramtsstudierende und Lehrkräfte, wobei eine praxisnahe Verknüpfung theoretischer sprachwissenschaftlicher Inhalte und didaktischer Methoden im Fokus steht. Für den Bereich Deutsch als Fremd- und Zweitsprache werden dabei sprachkontrastive Beispiele berücksichtigt.
Based on six weeks spent in the field on six Cabo Verdean Islands in September/ October 2016 and 2017, we present 18 additions to the checklist of terrestrial biodiversity of the archipelago (ten arthropods, one bird, two fungi, and five flowering plants). Four of them are first records for Cabo Verde, the others for particular islands. Most interesting are the apple of Sodom fruit fly Dacus longistylus, perhaps actively introduced for biocontrol of the toxic apple of Sodom tree and the additions to the distribution of several bee species of the genera Amegilla, Megachile, and Xylocopa. Our observations indicate that the biodiversity of Cabo Verde is still incompletely known and more fieldwork is needed.
Hämophilie A ist eine X-chromosomal rezessiv vererbte Krankheit, die aufgrund von Mutationen innerhalb des Gens von Gerinnungsfaktor VIII (FVIII) zum funktionellen Defekt oder zum Fehlen des körpereigenen FVIII führt. FVIII zirkuliert als Heterodimer und besteht aus einer schweren Kette mit der Domänenstruktur A1-A2-B und einer leichten Kette mit der Domänenstruktur A3-C1-C2. Bei Patienten unter Prophylaxe wird durch regelmäßige Substitution mit rekombinanten oder aus Plasma gewonnenen FVIII-Präparaten die Hämostase wiederhergestellt. Allerdings entwickeln hierbei etwa 30% der Patienten mit einer schweren Hämophilie eine FVIII-spezifische Immunantwort in Form von neutralisierenden Antikörpern (Inhibitoren). Die sogenannte Immuntoleranz-Therapie (engl. immune tolerance induction therapy, ITI) ist bisher die einzige etablierte Therapie, die zu einer dauerhaften Eradikation der FVIII-Inhibitoren und Induktion von Toleranz gegenüber FVIII führen kann. Die Therapie beruht auf einer meist täglichen Gabe hoher FVIII-Dosen, welche sich, je nach Behandlungsdauer, über Wochen bis hin zu Jahren erstrecken kann. Bei etwa 30% der Patienten ist diese Therapie nicht erfolgreich. Für solche Patienten besteht die Gefahr lebensbedrohlicher, unkontrollierbarer Blutungen und erheblicher Gelenkschäden.
Die spezifische Ansteuerung des Membran-gebundenen Immunglobulin G (mIg) des B-Zellrezeptors (BZR) mithilfe von Immuntoxinen ist eine mögliche Option zur selektiven Eliminierung FVIII-spezifischer B-Zellen und somit zur Eradikation von FVIII-Inhibitoren. Solche Immuntoxine bestehen aus einer zellbindenden und einer zytotoxischen Domäne, welche nach Internalisierung zur Apoptose der Zielzelle führen soll. Da FVIII aufgrund der Größe als zellbindende Domäne ungeeignet ist, beschäftigt sich die vorliegende Arbeit mit der Entwicklung und Evaluierung alternativer Immuntoxine zur selektiven Eliminierung FVIII-spezifischer B-Zellen. Die FVIII-spezifische Immunantwort ist zwar polyklonal, jedoch vor allem gegen A2- und die C2-Domäne gerichtet. Aus diesem Grund wurden die humane A2- und C2-Domäne (hA2, hC2) als zellbindende Domäne verwendet und jeweils genetisch an eine verkürzte Version des Exotoxin A (ETA) aus Pseudomonas aeruginosa fusioniert, bei welcher die natürliche zellbindende Domäne entfernt wurde. Die rekombinanten Proteine wurden bakteriell produziert und im Anschluss an die Aufreinigung biochemisch charakterisiert. Während das bakterielle Expressionssystem für hA2-ETA nicht geeignet war, konnte hC2-ETA neben weiteren Kontrollproteinen mit korrekter Konformation der hC2-Domäne hergestellt und aufgereinigt werden.
Die Fähigkeit zur selektiven Eliminierung hC2-spezifischer B-Zellen wurde im weiteren Verlauf sowohl in vitro mithilfe einer hC2-spezifischen Hybridomazelllinie als auch ex vivo und in vivo mithilfe von Splenozyten aus FVIII-immunisierten FVIII-knockout Mäusen untersucht.
Durch Inkubation der hC2-spezifischen Hybridomazelllinie mit hC2-ETA konnten ca. 38 % der Zellen eliminiert werden. Weitere Untersuchungen der Zelllinie ergaben, dass diese keinen vollständigen funktionalen B-Zellrezeptor auf der Oberfläche exprimierte, welcher für die Bindung und die korrekte Internalisierung des Immuntoxins notwendig ist. Aufgrund dessen eignet sich diese Zelllinie nicht als Modell für eine genauere Analyse der in vitro Eliminierungseffizienz von hC2-ETA.
Weitere Analysen mithilfe von Splenozyten aus FVIII-immunisierten FVIII-knockout Mäusen haben jedoch gezeigt, dass durch ex vivo Inkubation der Splenozyten mit hC2-ETA, alle hC2-spezifischen B-Zellen vollständig, selektiv und konzentrations-abhängig eliminiert werden konnten. Auch die mehrfache Applikation von hC2-ETA in FVIII-immunisierten FVIII-knockout Mäusen führte bei der Hälfte der Tiere zur vollständigen Eliminierung aller hC2-spezifischen B-Zellen. Eine Reduktion des hC2-spezifischen Antikörpersignals konnte nach Gabe von hC2-ETA in allen behandelten Tieren beobachtet werden. Die unvollständige Eliminierung in der Hälfte der Tiere ist vermutlich auf die Präsenz hC2-spezifischer Antikörper zurückzuführen, die einen Teil des applizierten Immuntoxins neutralisiert haben, sodass nicht alle hC2-spezifischen Gedächtnis-B-Zellen erreicht und eliminiert werden konnten. Um die Eliminierungseffizienz von hC2-ETA weiter zu erhöhen, müsste das Behandlungsprotokoll geändert werden. Sowohl eine Verlängerung des Behandlungszeitraums als auch eine kombinierte Therapie aus FVIII und hC2-ETA sollte zu einer erhöhten Bioverfügbarkeit des Toxins und dadurch zu einer gesteigerten Eliminierungseffizienz führen.
Die Ausweitung des hier vorgestellten Ansatzes auf weitere FVIII-Domänen ist generell möglich, jedoch muss hierzu ein alternatives Expressionssystem aufgrund des eukaryotischen Ursprungs von FVIII in Betracht gezogen werden. Die hier vorgestellten Ergebnisse zeigen dennoch, dass FVIII-Domänen-Immuntoxine ein wirkungsvolles Mittel sind, um FVIII-spezifische B-Zellen selektiv zu eliminieren. Die Anpassung der Gabe von FVIII-Domänen-Immuntoxinen an die individuelle Immunantwort des Patienten könnte das Auftreten von Nebenwirkungen minimieren. Außerdem könnte eine kombinierte Therapie aus ITI und FVIII-Domänen-Immuntoxinen die Zeit bis zur Induktion von Toleranz verkürzen und die Chancen für den generellen Therapieerfolg erhöhen.
Mit Dashcams den Verkehr aufzuzeichnen, kann nach einem Unfall in einem zivilrechtlichen Haftpflichtprozess sehr nützlich sein – obwohl man das datenschutzrechtlich eigentlich nicht darf. Der BGH hat in dieser Woche (BGH, Urt. v. 15. Mai 2018 – VI ZR 233/17) zwei rechtliche Problemlagen geklärt, die deutsche Gerichte seit geraumer Zeit beschäftigt haben: Zum einen betrifft dies die datenschutzrechtliche Zulässigkeit des Einsatzes von Dashcams im öffentlichen Verkehrsraum. Zum anderen deren zivilprozessuale Verwertbarkeit, insbesondere wenn die Aufnahmen rechtswidrig erfolgten.
Weltanschauung
(2018)
In einem leicht zugeschnittenen Sinn kann die Einsicht, dass "Welt je schon übersetzt" ist, als gedanklicher Kern der im 19. Jahrhundert sich durchsetzenden 'Weltanschauung' betrachtet werden. Dass die Welt dem Menschen niemals gar nicht und niemals vollständig gegeben ist, dass sie immer schon da und doch immer neu zu perspektivieren ist, hat in diesem Wort Ausdruck gefunden. Dadurch wird nun allerdings weniger verständlich als umso verwirrender, dass auch 'Weltanschauung' den 'Untranslatables' angehört. Als lexikalische Instanz eines modernen Pluralismus kann dieses Wort in seiner einzelsprachlichen Unbeugsamkeit nicht recht überzeugen.
Im Beitrag wird über die Vorkommen von Asplenium ruta-muraria und deren Entwicklung an Sekundärstandorten in der Ortslage Gleina (Burgenlandkreis, Sachsen-Anhalt) berichtet und das Verhalten der im unweit gelegenen Unstruttal verwilderten Gehölze Colutea arborescens, Populus nigra 'Italica' und Rhus typhina beschrieben. Die Beobachtungen umfassen den Zeitraum von etwa 1950 bis heute. Aussagen zum floristischen Status der Verwilderungen ergänzen die Ausführungen.
Background and purpose: The astroglial protein GFAP is a blood biomarker indicative of intracerebral hemorrhage in patients with acute stroke. Due to its brain specificity and the necessity of brain damage for its detectability in blood, we hypothesized that GFAP could be an interesting marker in cases with primary cerebral cause of death, e.g., traumatic brain injury.
Methods: All corpses scheduled for an autopsy in the Frankfurt Department of Forensic medicine within a 15-month period were included in the study. Cases with a known history of brain disease in the 3 months before death were excluded. During autopsy, blood was collected and GFAP serum levels were determined using a commercially available ELISA. The autopsy protocols were reviewed for the presence of a primary cerebral or a primary non-cerebral cause of death. Agony time was also determined.
Results: A total of 129 autopsy cases were included. GFAP concentrations did not differ between cerebral (median 0.96 μg/l, IQR 5.03) and non-cerebral causes of death (1.21 μg/l, 3.58). GFAP levels were found to be unaffected by hemolysis or post-mortem interval. GFAP levels were found to be increased in cases with prolonged agony times (median 1.76 μg/l [IQR 4.70]) compared to short (0.58 μg/l [0.58]; p<0.001) and ultra-short agony times (0.21 μg/l [0.12]; p = 0.002).
Conclusion: Post-mortem GFAP serum concentrations correlate with agony time and might therefore be useful for the evaluation of the severity of brain damage in prolonged death. Elevated GFAP serum levels do not indicate a primary cerebral cause of death.
Neuronal calcium signals propagating by simple diffusion and reaction with mobile and stationary buffers are limited to cellular microdomains. The distance intracellular calcium signals can travel may be significantly increased by means of calcium-induced calcium release from internal calcium stores, notably the endoplasmic reticulum. The organelle, which can be thought of as a cell-within-a-cell, is able to sequester large amounts of cytosolic calcium ions via SERCA pumps and selectively release them into the cytosol through ryanodine receptor channels leading to the formation of calcium waves. In this study, we set out to investigate the basic properties of such dendritic calcium waves and how they depend on the three parameters dendrite radius, ER radius and ryanodine receptor density in the endoplasmic membrane. We demonstrate that there are stable and abortive regimes for calcium waves, depending on the above morphological and physiological parameters. In stable regimes, calcium waves can travel across long dendritic distances, similar to electrical action potentials. We further observe that abortive regimes exist, which could be relevant for spike-timing dependent plasticity, as travel distances and wave velocities vary with changing intracellular architecture. For some of these regimes, analytic functions could be derived that fit the simulation data. In parameter spaces, that are non-trivially influenced by the three-dimensional calcium concentration profile, we were not able to derive such a functional description, demonstrating the mathematical requirement to model and simulate biochemical signaling in three-dimensional space.
The endoplasmic reticulum (ER) forms a complex endomembrane network that reaches into the cellular compartments of a neuron, including dendritic spines. Recent work discloses that the spine ER is a dynamic structure that enters and leaves spines. While evidence exists that ER Ca2+ release is involved in synaptic plasticity, the role of spine ER morphology remains unknown. Combining a new 3D spine generator with 3D Ca2+ modeling, we addressed the relevance of ER positioning on spine-to-dendrite Ca2+ signaling. Our simulations, which account for Ca2+ exchange on the plasma membrane and ER, show that spine ER needs to be present in distinct morphological conformations in order to overcome a barrier between the spine and dendritic shaft. We demonstrate that RyR-carrying spine ER promotes spine-to-dendrite Ca2+ signals in a position-dependent manner. Our simulations indicate that RyR-carrying ER can initiate time-delayed Ca2+ reverberation, depending on the precise position of the spine ER. Upon spine growth, structural reorganization of the ER restores spine-to-dendrite Ca2+ communication, while maintaining aspects of Ca2+ homeostasis in the spine head. Our work emphasizes the relevance of precise positioning of RyR-containing spine ER in regulating the strength and timing of spine Ca2+ signaling, which could play an important role in tuning spine-to-dendrite Ca2+ communication and homeostasis.
The opportunistic pathogen Acinetobacter baumannii is able to grow on carnitine. The genes encoding the pathway for carnitine degradation to the intermediate malic acid are known but the transporter mediating carnitine uptake remained to be identified. The open reading frame HMPREF0010_01347 (aci01347) of Acinetobacter baumannii is annotated as a gene encoding a potential transporter of the betaine/choline/carnitine transporter (BCCT) family. To study the physiological function of Aci01347, the gene was deleted from A. baumannii ATCC 19606. The mutant was no longer able to grow on carnitine as sole carbon and energy source demonstrating the importance of this transporter for carnitine metabolism. Aci01347 was produced in Escherichia coli MKH13, a strain devoid of any compatible solute transporter, and the recombinant E. coli MKH13 strain was found to take up carnitine in an energy‐dependent fashion. Aci01347 also transported choline, a compound known to be accumulated under osmotic stress. Choline transport was osmolarity‐independent which is consistent with the absence of an extended C‐terminus found in osmo‐activated BCCT. We propose that the Aci01347 is the carnitine transporter mediating the first step in the growth of A. baumannii on carnitine.
The vividly coloured Neotropical genus Callipia Guenée (1858) (Lepidoptera Linnaeus, 1758, Geometridae (Leach, 1815), Larentiinae (Leach, 1815), Stamnodini Forbes, 1948) is revised and separated into four species groups, according to a provisional phylogeny based on Cytochrome Oxidase I (COI) gene data and morphology. Fourteen new species are described using COI data and morphology: a) in the balteata group: C. fiedleri sp. nov., C. jakobi sp. nov., C. lamasi sp. nov.; b) in the vicinaria group: C. hausmanni sp. nov., C. walterfriedlii sp. nov.; c) in the parrhasiata group: C. augustae sp. nov., C. jonai sp. nov., C. karsholti sp. nov., C. levequei sp. nov., C. milleri sp. nov., C. sihvoneni sp. nov., C. wojtusiaki sp. nov. and d) in the constantinaria group: C. hiltae sp. nov., C. rougeriei sp. nov. One new subspecies is described: C. wojtusiaki septentrionalis subsp. nov. Two species are revived from synonymy: C. intermedia Dognin, 1914 stat. rev. and C. occulta Warren, 1904 stat. rev. The taxon hamaria Sperry, 1951 is transferred from being a junior synonym of C. constantinaria Oberthür, 1881 to being a junior synonym of C. occulta stat. rev. The taxon admirabilis Warren, 1904 is confirmed as being a junior synonym of C. paradisea Thierry-Mieg, 1904. The taxon languescens Warren, 1904 is confirmed as being a junior synonym of C. rosetta, Thierry-Mieg, 1904 and the taxon confluens Warren, 1905 is confirmed as being a junior synonym of C. balteata Warren, 1905. The status of the remaining species is not changed: C. aurata Warren, 1904, C. brenemanae Sperry, 1951, C. parrhasiata Guenée, 1858, C. flagrans Warren, 1904, C. fulvida Warren, 1907 and C. vicinaria Dognin. All here recognised 26 species are illustrated and the available molecular genetic information of 25 species, including Barcode Index Numbers (BINs) for most of the taxa is provided. The almost threefold increase from 10 to 26 valid species shows that species richness of tropical moths is strongly underestimated even in relatively conspicuous taxa. Callipia occurs from medium to high elevations in wet parts of the tropical and subtropical Andes from Colombia to northern Argentina. The early stages and host plants are still unknown.
Die vorliegende Studie setzt sich mit dem Adjektiv "neu" und seinem slowakischen Äquivalent "nový" systembezogen und pragmatisch auseinander. Wir befassen uns kontrastiv mit der Bedeutungsstruktur, mit der Kollokabilität und lexikographischen Auffassung dieser Adjektive. Um alle erwähnten Ebenen in ihrer Komplexität zu erfassen, darf man sie nicht voneinander getrennt untersuchen. Bei unserer Untersuchung gehen wir von der kodifizierten Bedeutung aus, die wir mit der realen Sprachverwendung vergleichen und ihre Anwendbarkeit an der aus den Korpora gewonnenen Daten überprüfen. Bei unserer kontrastiven Vorhegensweise ist der Ausgangspunkt die Auslegung der slowakischen Bedeutungsbeschreibung der lexikalischen Einheit "nový". Zunächst erweitert sich der Forschungsgegenstand um den Vergleich der jeweiligen Erläuterungen der deutschen lexikalischen Einheit "neu" in verschiedenen deutschen Wörterbüchern. Im Anschluss an die semantische Analyse der einzelnen Adjektive in den zwei von uns ausgewählten Sprachen überprüfen wir, ob und inwiefern bei der Bedeutungsbeschreibung der Übersetzungsäquivalente "nový" und "neu" eine analogische Auslegung verwendbar ist.
Angesichts heutiger Umweltprobleme ist die Stärkung positiver Mensch-Natur-Beziehungen wichtiger denn je. Zeitgenössische Umweltbildung zielt darauf ab, Motivation und Einstellungen zu fördern sowie eine grundlegende Wissensbasis zu schaffen (IUCN, UNEP, & WWF, 1991; Potter, 2010), um einen selbstbestimmten, verantwortungsvollen Umgang mit der Natur zu ermöglichen. Positiver Naturbezug und Umwelteinstellungen gelten als Basis für aktiven Umweltschutz. Direkte Naturerfahrungen gelten dabei als didaktische Möglichkeit, die Motivation für Umweltschutz zu festigen (Kaiser, Roczen, & Bogner, 2008). Einstellungen verändern sich im Laufe des Lebens und so kann das Alter eine wichtige Rolle bezüglich der Effektivität von Umweltbildungsprogrammen spielen (Ernst & Theimer, 2011). Auch Umweltwissen gilt als Grundlage von Umwelthandeln. Denn sinnliche Erfahrungen allein führen nicht zum Verständnis ökologischer Zusammenhänge (Frick, Kaiser, & Wilson, 2004; Liefländer, Bogner, Kibbe, & Kaiser, 2015). Die biologiedidaktische Forschung sieht Fakten-, Handlungs- und Effektivitäts-wissen als zentral für die Genese von Umwelthandeln (Frick, Kaiser, & Wilson, 2004). Isoliertes Fachwissen wiederum führt nach aktueller Erkenntnis auch nicht zur Entwicklung von Haltungen und Wertvorstellungen, welche unser Handeln beeinflussen (Barr, 2003; Finger, 2010; Leiserowitz, Kates, & Parris, 2005).
Bis heute sind altersbasierte Unterschiede bei Schülerinnen und Schülern bezüglich ihrer Naturverbundenheit und Umwelteinstellungen nicht hinreichend untersucht. Auch ist die nötige Dauer der Naturerfahrungen noch nicht nachgewiesen. Es gibt bislang keine Studie, die Umwelteinstellungen, -wissen und –handeln von Kindern verschiedener Regionen der Erde untersucht und Daten auf internationaler Ebene erhoben und ausgewertet hat. Die gezielte Integration der drei Umweltwissensarten in ein solch globales Umweltbildungsprojekt stellt eine zusätzliche bislang nicht angegangene Aufgabe dar. Die vorliegende Arbeit schließt diese Forschungslücken, indem sie auf internationaler Ebene jene Variablen mit einbezieht, die einen nahezu vollständigen Eindruck der Effektivität von Umweltbildung in verschiedenen Regionen, Sozialisationen und Altersklassen zulässt. So wird der Einfluss eines umfassenden Umweltbildungsprogramms auf Naturverbundenheit, Umwelteinstellungen und -wissen der verschiedenen Typen untersucht und ein Bezug zur eventuellen Veränderung des Umwelthandelns hergestellt. Dabei stehen sowohl traditionelle als noch unerforschte mögliche Einflussfaktoren im Fokus. Die Studie umfasst insgesamt 1454 Schülerinnen und Schüler aus Bangladesch, Malaysia, Deutschland und Singapur, die alle an dem Umweltbildungsprojekt „Global denken, lokal handeln – wir schützen unsere Umwelt!“ bzw. “Think global, act local – we protect our environment!“ teilgenommen haben.
Zur Messung der Naturverbundenheit diente Schulz’ INS-Skala (Inclusion of Nature in Self) (2002). Umwelteinstellungen wurden mit dem 2-MEV-Modell (Two Major Environmental Values) gemessen (Johnson & Manoli, 2011). Eine Skala zur Erhebung von Umweltwissen wurde eigens erstellt und hinsichtlich der drei Wissenstypen nochmals modelliert. Eine Skala zur Ermittlung von Umwelthandeln wurde auf Grundlage von Bögeholz (1999) erstellt. Alle Skalen waren Teil eines Fragebogens, welcher in Form eines Pre-, Post- und Follow-up-Test eingesetzt wurde. Kinder aus Parallelklassen, die nicht am Projekt teilnahmen, aber Klassenunterricht zu den jeweiligen Themen erhielten, dienten als Kontrollgruppen.
Die Ergebnisse bestätigen einen positiven Effekt außerschulischer Umweltbildung bezüglich der Entwicklung der untersuchten Variablen. So wurde nach der Teilnahme am eintägigen und auch nach dem fünftägigen Umweltbildungsprogramm eine signifikante Verstärkung des Naturbezugs gemessen, wohingegen die Kontrollgruppen keine messbare Veränderung zeigten. Jedoch nur die fünftägige Intervention führte auch zu nachhaltigen Veränderungen. Hierbei am stärksten beeinflusst wurden Kinder zwischen sieben und neun Jahren.
Bei der Untersuchung demographischer Einflussfaktoren auf Umwelteinstellung, -wissen und –handeln stellten sich das Wohnsitzland sowie die städtische bzw. ländliche Prägung der Wohngegend als entscheidend heraus. So waren dies die einflussreichsten Determinanten zur Vorhersage des Grundvorhandenseins sowie Veränderungen der untersuchten Variablen in Folge der Bildungsmaßnahme. Einzig bei der Entwicklung des Umwelthandelns schien die direkte Naturerfahrung unwesentlich, zeigten die Kontrollgruppen ähnlichen Wandel in ihrem aktiven Einsatz für die Umwelt. Im internationalen Vergleich scheint die komplexe Verkettung diverser einflussnehmender Faktoren, wie der Wohlstand des jeweiligen Staates, das generelle politische System sowie spezifische bildungspolitische Begebenheiten, den Erfolg von Umweltbildungsprogrammen mit zu bestimmen.
Die Daten zeigen, dass Faktenwissen Grundlage für Handlungs- und Effektivitätswissen ist. Alle Dimensionen wurden durch die Intervention signifikant gesteigert. Effektivitätswissen wuchs am stärksten. Auch das Umweltverhalten wurde positiv verstärkt. Jedoch ließen sich nur schwache Korrelationen zwischen den einzelnen Wissenstypen und Handeln feststellen. Zusammenfassend war das durchgeführte Bildungsprojekt erfolgreich in der Förderung von Naturverbundenheit sowie Umwelteinstellungen, -wissen und- handeln. Die Ergebnisse werden im Rahmen dieser Arbeit im Hinblick auf ihre Bedeutung für die schulische Umweltbildung sowie die didaktische Forschung erörtert.
Luise Mühlbach (Pseudonym für Clara Mundt) (1814-1873) gehörte zur ersten Generation der sogenannten Berufsschriftstellerinnen, d.h. der ersten Schriftstellerinnen, die durch ihr Schreiben finanziell unabhängig sein konnten. Die Tatsache an sich galt schon vielen Zeitgenossen als Provokation und Emanzipationsstreben, da die Geschlechtergrenzen durch das Ausüben eines Männerberufes überschritten wurden. Über einen längeren Zeitraum war Mühlbach sogar Alleinverdienerin der Familie, da ihr Ehemann, Theodor Mundt, frühzeitig erkrankt und 1861 gestorben war. Zudem gehörte sie ab den 1850er Jahren zu den populärsten BestsellerautorInnen ihrer Zeit und sie wurde somit schnell erfolgreicher als Theodor Mundt. Luise Mühlbach hat sich sehr früh gegen die Konvenienzehe und für eine Eheschließung aus Liebe und Zuneigung geäußert und hat dies in ihrer Ehe vorgelebt.
Mutations causing aberrant splicing are frequently implicated in human diseases including cancer. Here, we establish a high-throughput screen of randomly mutated minigenes to decode the cis-regulatory landscape that determines alternative splicing of exon 11 in the proto-oncogene MST1R (RON). Mathematical modelling of splicing kinetics enables us to identify more than 1000 mutations affecting RON exon 11 skipping, which corresponds to the pathological isoform RON∆165. Importantly, the effects correlate with RON alternative splicing in cancer patients bearing the same mutations. Moreover, we highlight heterogeneous nuclear ribonucleoprotein H (HNRNPH) as a key regulator of RON splicing in healthy tissues and cancer. Using iCLIP and synergy analysis, we pinpoint the functionally most relevant HNRNPH binding sites and demonstrate how cooperative HNRNPH binding facilitates a splicing switch of RON exon 11. Our results thereby offer insights into splicing regulation and the impact of mutations on alternative splicing in cancer.