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Delayed-onset muscle soreness (DOMS) is a common symptom in people participating in exercise, sport, or recreational physical activities. Several remedies have been proposed to prevent and alleviate DOMS. In 2008 and 2015, two studies have been conducted to investigate the effects of acupuncture on symptoms and muscle function in eccentric exercise-induced DOMS of the biceps brachii muscle. In 2008 a prospective, randomized, controlled, observer and subject-blinded trial was undertaken with 22 healthy subjects (22–30 years; 12 females) being randomly assigned to three treatment groups: real acupuncture (deep needling at classic acupuncture points and tender points; n = 7), sham-acupuncture (superficial needling at non-acupuncture points; n = 8), and control (n = 7). In 2015, a five-arm randomized controlled study was conducted with 60 subjects (22 females, 23.6 ± 2.8 years). Participants were randomly allocated to needle, laser, sham needle, sham laser acupuncture, and no intervention.
In both cases treatment was applied immediately, 24 and 48 hours after DOMS induction.
The outcome measures included pain perception (visual analogue scale; VAS), mechanical pain threshold (MPT), maximum isometric voluntary force (MIVF) and pressure pain threshold (PPT).
Results: In 2008, following nonparametric testing, there were no significant differences between groups in outcome measures at baseline. After 72 hours, pain perception (VAS) was significantly lower in the acupuncture group compared to the sham acupuncture and control subjects. However, the mean MPT and MIVF scores were not significantly different between groups. This lead to the conclusion, that acupuncture seemed to have no effects on MPT and muscle function, but reduced perceived pain arising from exercise-induced DOMS.
The more recent results from 2015 indicated that neither verum nor sham interventions significantly improved outcomes within 72 hours when compared with the no treatment control (P > 0.05).
Introduction: Ferroptosis has recently been identified as a form of programmed cell death caused by an accumulation of lipid reactive oxygen species (ROS). However, little is yet known about the role in hepatocellular carcinoma (HCC) and its signalling mechanism as well the modulation of ROS.
Material and methods: Human HCC cell lines were treated with different concentrations of ROS modulators (Auranofin, Erastin, BSO). Cell death was determined by analysis of PI-stained nuclei using flow cytometry. ROS production and lipid peroxidation were analysed at early time points before cell death starts. For mechanistic studies we performed Western Blot and a Proteome array. Different inhibitors of cell death target proteins, ROS-scavengers as well as lipoxygenase inhibitors were used. To investigate the functional relevance of NAPDH oxidases (NOX) 1 and 4 for ROS modulation and ferroptosis we genetically silenced its genes using three distinct siRNAs and we used the NOX1/4-inhibitor GKT137831.
Results and discussions: Compared to the single treatment, Auranofin/BSO-cotreatment as well as Erastin/BSO-cotreatment acted in concert to trigger cell death and to reduce cell viability of HCC cells in a dose- and time-dependent manner. Furthermore, both cotreatments induce ROS production, lipid peroxidation and ferroptotic cell death, which could be inhibited by the use of Ferrostatin-1 (inhibitor of lipid peroxidation) and Liproxstatin-1 (specific inhibitor of ferroptosis). The broad-range caspase inhibitor zVAD.fmk failed to rescue cells from Auranofin/BSO- or Erastin/BSO-cotreatment induced cell death. No activation of caspases-3 could be seen in the proteome profiler apoptosis assay. Importantly, the selective lipoxygenase (LOX) inhibitor Baicalain and the pan-LOX inhibitor NDGA protect HCC cells from Auranofin/BSO- and Erastin/BSO-cotreatment stimulated lipid peroxidation, ROS generation and cell death, indication that the induction of ferroptosis may bypass apoptosis resistance of HCC cells. Mechanistic studies showed that Auranofin/BSO-cotreatment decreased TrxR-activity, led to Nrf2 accumulation and promoted the activation of HO-1. In contrast, NOX 1 and 4 were involved in Erastin/BSO-mediated cell death and the use of the NOX1/4-inhibitor GKT137831 rescued HCC cells from the Erastin/BSO-induced cell death.
Conclusion: By providing new insights into the molecular regulation of ROS and ferroptosis, our study contributes to the development of novel treatment strategies to reactivate programmed cell death in HCC cells.
Challenges of FAIR phase 0
(2018)
After two-year's shutdown, the GSI accelerators plus the latest addition of storage ring CRYRING, will be back into operation in 2018 as the FAIR phase 0 with the goal to fulfill the needs of scientific community and the FAIR accelerators and detector development. Even though GSI has been well known for its operation of a variety of ion beams ranging from proton up to uranium for multi research areas such as nuclear physics, astrophysics, biophysics, material science, the upcoming beam time faces a number of challenges in re-commissioning its existing circular accelerators with brand new control system and upgrade of beam instrumentations, as well as in rising failures of dated components and systems. The cycling synchrotron SIS18 has been undergoing a set of upgrade measures for fulfilling future FAIR operation, among which many measures will also be commissioned during the upcoming beam time. This paper presents the highlights of the challenges such as re-establishing the high intensity heavy ion operation as well as parallel operation mode for serving multi users. The status of preparation including commissioning results will also be reported.
An automated beam-setting optimization application has been implemented on top of FAIR’s control system software stack based on CERN’s LSA framework. The optimization functionality is built using the Jenetics software library implemented in Java. Tests of the software with beam have been performed at the CRYRING@ESR ion storage ring.
We investigate privacy concerns and the privacy behavior of users of the AR smartphone game Pokémon Go. Pokémon Go accesses several functionalities of the smartphone and, in turn, collects a plethora of data of its users. For assessing the privacy concerns, we conduct an online study in Germany with 683 users of the game. The results indicate that the majority of the active players are concerned about the privacy practices of companies. This result hints towards the existence of a cognitive dissonance, i.e. the privacy paradox. Since this result is common in the privacy literature, we complement the first study with a second one with 199 users, which aims to assess the behavior of users with regard to which measures they undertake for protecting their privacy. The results are highly mixed and dependent on the measure, i.e. relatively many participants use privacy-preserving measures when interacting with their smartphone. This implies that many users know about risks and might take actions to protect their privacy, but deliberately trade-off their information privacy for the utility generated by playing the game.
This paper provides an assessment framework for privacy policies of Internet of Things Services which is based on particular GDPR requirements. The objective of the framework is to serve as supportive tool for users to take privacy-related informed decisions. For example when buying a new fitness tracker, users could compare different models in respect to privacy friendliness or more particular aspects of the framework such as if data is given to a third party. The framework consists of 16 parameters with one to four yes-or-no-questions each and allows the users to bring in their own weights for the different parameters. We assessed 110 devices which had 94 different policies. Furthermore, we did a legal assessment for the parameters to deal with the case that there is no statement at all regarding a certain parameter. The results of this comparative study show that most of the examined privacy policies of IoT devices/services are insufficient to address particular GDPR requirements and beyond. We also found a correlation between the length of the policy and the privacy transparency score, respectively.
Von der Gruppenarbeit zum Community Building - der "Digital Creative Space" der SUB Göttingen
(2018)
Die Förderung der digitalen Kompetenzen von Studierenden und die Entwicklung adaptiver, interaktiver und multimedialer (digitaler), diversitätsorientierter Lernumgebungen sind Schwerpunkte der Digitalen Hochschulbildung. Dies hat auch erheblichen Einfluss auf die konzeptionelle Planung und Gestaltung von physischen Lernraumangeboten wissenschaftlicher Bibliotheken. Ein deutliches Desiderat ist dabei die Bereitstellung niedrigschwelliger, kollaborativ nutzbarer Lernumgebungen, in denen Studierende (und auch Lehrende) gemeinsam digitale Kenntnisse erwerben, explorativ erproben und stärken können, um den Anforderungen sowohl im Studium als auch im späteren Berufsleben gerecht werden zu können. Gemeinsam mit dem Service für Digitales Lernen und Lehren und der Abteilung IT der Universität Göttingen hat die Benutzungsabteilung der SUB Göttingen ein Raumkonzept für ein "Digital Creative Space" erarbeitet, das in gemeinsamen Workshops mit Studierenden und Lehrenden des Göttinger Campus weiterentwickelt wurde. Sein Start in der hochfrequentierten Zentralbibliothek ist für 2018 geplant. Das Ergebnis dieses Prozesses ist eine Bündelung interdisziplinärer Labs verschiedenster technischer Ausstattung und interdisziplinärer Gruppenarbeit - das "Digital Creative Space". Ziel ist, den Nutzenden das eigenständige Entwickeln digitaler Kompetenzen zu ermöglichen und kreative Prozesse zu unterstützen - und dabei "communities of practice" zu initiieren oder zu befördern. Das Konzept, seine Entwicklungs- und weiteren Umsetzungsschritte einschließlich der Darstellung des partizipativen Prozesses sind Inhalt dieses Vortrags.
Augmented reality (AR) gained much public attention since the success of Pok´emon Go in 2016. Technology companies like Apple or Google are currently focusing primarily on mobile AR (MAR) technologies, i.e. applications on mobile devices, like smartphones or tablets. Associated privacy issues have to be investigated early to foster market adoption. This is especially relevant since past research found several threats associated with the use of smartphone applications. Thus, we investigate two of the main privacy risks for MAR application users based on a sample of 19 of the most downloaded MAR applications for Android. First, we assess threats arising from bad privacy policies based on a machine-learning approach. Second, we investigate which smartphone data resources are accessed by the MAR applications. Third, we combine both approaches to evaluate whether privacy policies cover certain data accesses or not. We provide theoretical and practical implications and recommendations based on our results.
Die Erfahrung, "…dass alles auch ganz anders sein könnte" ist die wohl wichtigste Erfahrung in Bildungsprozessen. Die Entdeckung von Möglichkeiten, Perspektivwechseln und transformatorischen Selbst-Bildungsprozessen ist zentral für eine gelungene kulturelle Bildungssituation. (Birgit Mandel, 2005).
Die Hessischen Schülerakademien zur Förderung besonders engagierter und begabter junger Menschen wurden bewusst als ein Unterfangen des Forschenden Lernens gegründet und fühlen sich diesem Leitgedanken im Kontext kultureller Bildung verpflichtet. Dieser Satz klingt zunächst einmal gut und zeitgemäß. Doch was steckt genau dahinter?
Das Akademiejahr 2018 hatte neben den beiden Schülerakademien für die Mittelstufe und die Oberstufe noch einen weiteren Höhepunkt: das Symposium "Kulturelle Bildung auf dem Weg" (vom 2. bis 4. März 2018, ausgerichtet von Burg Fürsteneck gemeinsam mit dem Schulentwicklungsprogramm KulturSchule des Hessischen Kultusministeriums und dem Weiterbildungsmaster Kulturelle Bildung an Schulen der Uni Marburg). Es wurde von unserem Schirmherrn, Kultusminister Prof. Dr. R. Alexander Lorz, eröffnet und hatte unter anderem das Ziel, in der Begegnung von Bildungsexpert*innen und -praktiker*innen eine Fachdebatte über "Qualitätsbedingungen in der Kulturellen Bildung am Beispiel der Schülerakademien und der Kulturschulen in Hessen" anzustoßen.