Refine
Year of publication
- 2007 (584) (remove)
Document Type
- Article (207)
- Doctoral Thesis (79)
- Part of Periodical (70)
- Working Paper (62)
- Part of a Book (53)
- Book (41)
- Conference Proceeding (29)
- Report (14)
- Preprint (13)
- Review (9)
Language
- English (584) (remove)
Has Fulltext
- yes (584) (remove)
Keywords
- Referenzidentität (11)
- Englisch (10)
- Deutsch (9)
- Spracherwerb (7)
- focus (7)
- Referenz <Linguistik> (6)
- Sprachverstehen (6)
- inflammation (6)
- wassergefiltertes Infrarot A (wIRA) (6)
- water-filtered infrared-A (wIRA) (6)
Institute
- Medizin (61)
- Biochemie und Chemie (36)
- Physik (35)
- Biowissenschaften (31)
- Center for Financial Studies (CFS) (30)
- Extern (23)
- Wirtschaftswissenschaften (20)
- E-Finance Lab e.V. (19)
- Institut für Deutsche Sprache (IDS) Mannheim (19)
- Frankfurt Institute for Advanced Studies (FIAS) (17)
Language universals are statements that are true of all languages, for example: “all languages have stop consonants”. But beneath this simple definition lurks deep ambiguity, and this triggers misunderstanding in both interdisciplinary discourse and within linguistics itself. A core dimension of the ambiguity is captured by the opposition “absolute vs. statistical universal”, although the literature uses these terms in varied ways. Many textbooks draw the boundary between absolute and statistical according to whether a sample of languages contains exceptions to a universal. But the notion of an exception-free sample is not very revealing even if the sample contained all known languages: there is always a chance that an as yet undescribed language, or an unknown language from the past or future, will provide an exception.
Relying on the existing estimates for the production cross sections of mini black holes in models with large extra dimensions, we review strategies for identifying those objects at collider experiments. We further consider a possible stable final state of such black holes and discuss their characteristic signatures. Keywords: Black holes
The taxonomy, diversity, and distribution of the aquatic insect order Trichoptera, caddisflies, are reviewed. The order is among the most important and diverse of all aquatic taxa. Larvae are vital participants in aquatic food webs and their presence and relative abundance are used in the biological assessment and monitoring of water quality. The species described by Linnaeus are listed. The morphology of all life history stages (adults, larvae, and pupae) is diagnosed and major features of the anatomy are illustrated. Major components of life history and biology are summarized. A discussion of phylogenetic studies within the order is presented, including higher classification of the suborders and superfamilies, based on recent literature. Synopses of each of 45 families are presented, including the taxonomic history of the family, a list of all known genera in each family, their general distribution and relative species diversity, and a short overview of family-level biological features. The order contains 600 genera, and approximately 13,000 species.
Lepidoptera phylogeny and systematics : the state of inventorying moth and butterfly diversity
(2007)
The currently recognized robust support for the monophyly of the Lepidoptera (and the superorder Amphiesmenoptera comprising Lepidoptera + Trichoptera) is outlined, and the phylogeny of the principal lineages within the order is reviewed succinctly. The state of the taxonomic inventory of Lepidoptera is discussed separately for ‘micro-moths’, ‘macro-moths’ and butterflies, three assemblages on which work has followed historically somewhat different paths. While currently there are about 160,000 described species of Lepidoptera, the total number of extant species is estimated to be around half a million. On average, just over one thousand new species of Lepidoptera have been described annually in recent years. Allowing for the new synonyms simultaneously established, the net increase in species numbers still exceeds 800/year. Most of the additions are foreseeable in the micro-moth grade, but even for butterflies ca 100 species are added annually. Examples of particularly interesting new high-rank taxa that have been described (or whose significance has become realized) since the middle of the 20th century include the non-glossatan lineages represented by Agathiphaga and Heterobathmia and the heteroneuran families Andesianidae, Palaephatidae, Hedylidae and Micronoctuidae. Some thoughts on how present and future systematic lepidopterology might be prioritised are presented.
Event-by-event multiplicity fluctuations in nucleus-nucleus collisions from low SPS up to RHIC energies have been studied within the HSD transport approach. Fluctuations of baryonic number and electric charge also have been explored for Pb+Pb collisions at SPS energies in comparison to the experimental data from NA49. We find a dominant role of the fluctuations in the nucleon participant number for the final hadron multiplicity fluctuations and a strong influence of the experimental acceptance on the final results. Critical Point and Onset of Deconfinement - 4th International Workshop July 9 - 13, 2007 Darmstadt, Germany
This study analyzes storyline structure in three Hausa home videos; Mai Kudi (The Rich Man), Sanafahna (with time truth shall dawn) and Albashi (Salary). The study measures storyline structure in these films against a Hollywood film industry model of story writing “the Hero's Journey”. It uses narrative analysis as its analytical tool, and narrative theory as its framework. After analyzing these videos, the study found that the major elements of storyline structure in Vogler's model formed the framework of the storyline structure in Hausa home videos analyzed. However, in spite of the preponderance of these elements within the storyline structure, there are significant variations to Vogler's model. Specifically, Vogler's model has some twelve stages spread on the universal structure of storytelling, i.e. beginning, middle and end. Few of these stages were found to exist in Hausa narrative structure, perhaps due to cultural differences between Western, Indian and Hausa cultures. The study therefore recommends screenwriters and producers to be aware of the existence of standard models of scriptwriting. It also recommends more training for script writers in the Hausa film industry.
Since about the year 2000 a hitherto unidentified species of the genus Leiobunum C. L. Koch, 1839, has rapidly invaded central and western Europe. Records are known from The Netherlands (probably the country of first occurrence in Europe), Germany, Austria and Switzerland. This introduced species, until now, mainly inhabits walls of buildings and rocky environments. Adults characteristically aggregate during daytime into groups of up to 1.000 individuals. The species is described and details on its present distribution, habitat preference, phenology and behaviour are presented.
Evaluating phonological status : significance of paradigm uniformity vs. prosodic group effects
(2007)
A central concern of linguistic phonetics is to define criteria for determining the phonological status of sounds or sound properties observed in phonetic surface form. Based on acoustic measurements we show that the occurrence of syllabic sonorants vs. schwa-sonorant sequences in German is determined exclusively by segmental and prosodic structure, with no paradigm uniformity effects. We argue that these findings are consistent with a uniform representation of syllabic sonorants as schwa sonorant sequences in the lexicon. The stability of schwa in CVC-suffixes (e.g. the German diminutive suffix -chen), as opposed to its phonetic absence in a segmentally comparable underived context, is argued to be conditioned by the prosodic organisation of such suffixes external to the phonological word of the stem.
The work presented in this thesis addresses a key issue of the CBM experiment at FAIR, which aims to study charm production in heavy ion collisions at energies ranging from 10 to 40 AGeV . For the first time in this kinematical range, open charm mesons will be used as a probe of the nuclear fireball. Despite of their short decay length, which is typically in the order of few 100 µm in the laboratory frame, those mesons will be identified by reconstructing their decay vertex.
After he had only tightly lost the election in July 2006, Andrés Manuel López Obrador and his Coalición claimed fraud and asserted that unfair conditions during the campaign had diminished his chances to win the presidency. The paper investigates this latter allegation centering on a perceived campaign of hate, unequal access to campaign resources and malicious treatment by the mass media. It further analyzes the mass media’s performance during the conflictual post electoral period until the final decision of the Federal Electoral Tribunal on September 5th, 2006. While the media’s performance during the campaign tells us about their compliance with fair media coverage mechanisms that have been implemented by electoral reforms in the 1990s, the mass media is uncontained by such measures after the election. Thus, their mode of coverage of the postelectoral conflicts allows us to “test” the mass media’s transformation to a more unbiased, social responsible “fourth estate”. Finally the paper scrutinizes whether the claims of fraud and the protests by the leftist movement resulted in lower levels of institutional trust and democratic support. The analysis of the media performance is based on data provided by the Federal Electoral Institute (IFE). Its Media Monitor encompassed more than 150 TV stations, 240 radio stations and 200 press publications. However, there is no comparable data available for the postelectoral period. Interviews with Mexican media experts, which the author has conducted during the postelectoral period, serve as empirical basis for the second part. Data on the public opinions and attitudes of Mexican citizens are taken from the 2007 Latinobarometro, the 2006 Encuesta Nacional and several polls conducted by Grupo Reforma. The results do not support López Obradors notions. Even though a strong party bias is characteristic of the Mexican media system, all findings hint at a continuity of balanced campaign coverage and fair access to mass media publicity. Coverage during the postelectoral period was more polarized, yet both sides remained at least partially open for oppositional views. The claims of fraud, mass protest mobilization and anti-institutional discourse by Lopez Obrador’s leftist movement seem not to have caused significant loss in institutional trust, support of and satisfaction with democracy, even though these levels remain quite low.
Arabidopsis cell walls contain large amounts of pectins and hemicelluloses, which are predominantly synthesized via the common precursor UDP-glucuronic acid. The major enzyme for the formation of this nucleotide-sugar is UDP-glucose dehydrogenase, catalysing the irreversible oxidation of UDP-glucose into UDP-glucuronic acid. Four functional gene family members and one pseudogene are present in the Arabidopsis genome, and they show distinct tissue-specific expression patterns during plant development. The analyses of reporter gene lines indicate gene expression of UDP-glucose dehydrogenases in growing tissues. The biochemical characterization of the different isoforms shows equal affinities for the cofactor NAD+ (~40 µM) but variable affinities for the substrate UDP-glucose (120–335 µM) and different catalytic constants, suggesting a regulatory role for the different isoforms in carbon partitioning between cell wall formation and sucrose synthesis as the second major UDP-glucose-consuming pathway. UDP-glucose dehydrogenase is feedback inhibited by UDP-xylose. The relatively (compared with a soybean UDP-glucose dehydrogenase) low affinity of the enzymes for the substrate UDP-glucose is paralleled by the weak inhibition of the enzymes by UDP-xylose. The four Arabidopsis UDP-glucose dehydrogenase isoforms oxidize only UDP-glucose as a substrate. Nucleotide-sugars, which are converted by similar enzymes in bacteria, are not accepted as substrates for the Arabidopsis enzymes.
Another accruing and evolving collection holding published university documents (documents made publicly available) and non-official institutional records, plus 'grey literature' and ephemera relating to UB and its forerunner institutions. It includes documents harvested from UB Website. This is an artificially created collection. Some of these records may also exist in the homogenous institutional archive collections and in the BDSC.
Iterative arrays (IAs) are a, parallel computational model with a sequential processing of the input. They are one-dimensional arrays of interacting identical deterministic finite automata. In this note, realtime-lAs with sublinear space bounds are used to accept formal languages. The existence of a proper hierarchy of space complexity classes between logarithmic anel linear space bounds is proved. Furthermore, an optimal spacc lower bound for non-regular language recognition is shown. Key words: Iterative arrays, cellular automata, space bounded computations, decidability questions, formal languages, theory of computation
Applying an investment perspective to higher education, the paper presents detailed empirical evidence on the rate of return to higher education and its determinants. Employing a sample of 17,180 higher education graduates derived from the German Labor Force Survey 2004, we show considerable variation in the rates of return to higher education across the different subjects, with some subjects on average not representing attractive private investments from an economic point of view. We find that the decision what to study is worth several hundred thousand Euros. Applying regression analysis, we find gender- and degree-specific return advantages only in certain subjects. Comparing the return of an investment in higher education and the production cost of higher education, we show that more expensive subjects (apart from Medicine) yield a lower return. When considering the cost of study, the overall order of attractiveness of the different forms of education remains stable, but the investment in further subjects is no longer clearly attractive. Keywords: Returns to Education, Human Capital, Higher Education Earnings Capacity.
Does BPO pay off at the firm-level? Although there are several studies which analyze the potential benefits of BPO, there is a virtual absence of research papers on BPO outcomes. Based on an analysis of 137 Business process outsourcing (BPO) ventures at 254 German banks in a period between 1994 and 2005, we found that the outsourcer's financial performance in terms of profitability and cost efficiency was increased significantly compared to industry peers without BPO. The increase stems not from workforce reductions but rather from increased employee productivity. Further, we show how BPO governance ensures BPO success: individually negotiated outsourcing contracts help to improve cost efficiency and profitability measures. Relational governance based on trust has only positive effects on profitability. Keywords: Business Process Outsourcing, firm performance, firm characteristics, banking, German banks, governance JEL Classifications: G21, L14, L21, L24
Gothic gen.pl. -e
(2007)
Humans possess a number concept that differs from its predecessors in animal cognition in two crucial respects: (1) it is based on a numerical sequence whose elements are not confined to quantitative contexts, but can indicate cardinal/quantitative as well as ordinal and even nominal properties of empirical objects (e.g. ‘five buses’: cardinal; ‘the fifth bus’: ordinal; ‘the #5 bus’: nominal), and (2) it can involve recursion and, via recursion, discrete infinity. In contrast to that, the predecessors of numerical cognition that we find in animals and human infants rely on finite and iconic representations that are limited to cardinality and do not support a unified concept of number. In this paper, I argue that the way such a unified number concept could evolve in humans is via verbal sequences that are employed as numerical tools, that is, sequences of words whose elements are associated with empirical objects in number assignments. In particular, I show that a certain kind of number words, namely the counting sequences of natural languages, can be characterised as a central instance of verbal numerical tools. I describe a possible scenario for the emergence of such verbal numerical tools in human history that starts from iconic roots and that suggests that in a process of co-evolution, the gradual emergence of counting sequences and the development of an increasingly comprehensive number concept supported each other. On this account, it is language that opened the way for numerical cognition, suggesting that it is no accident that the same species that possesses the language faculty as a unique trait, should also be the one that developed a systematic concept of number.
Attraction and commercial success of web sites depend heavily on the additional values visitors may find. Here, individual, automatically obtained and maintained user profiles are the key for user satisfaction. This contribution shows for the example of a cooking information site how user profiles might be obtained using category information provided by cooking recipes. It is shown that metrical distance functions and standard clustering procedures lead to erroneous results. Instead, we propose a new mutual information based clustering approach and outline its implications for the example of user profiling.
We study various fluctuation and correlation signals of the deconfined state using a dynamical recombination approach (quark Molecular Dynamics, qMD). We analyse charge ratio fluctuations, charge transfer fluctuations and baryon-strangeness correlations as a function of the center of mass energy with a set of central Pb+Pb/Au+Au events from AGS energies on (Elab = 4 AGeV) up to the highest RHIC energy available (V sNN = 200 GeV) and as a function of time with a set of central Au+Au qMD events at V sNN = 200 GeV with and without applying our hadronization procedure. For all studied quantities, the results start from values compatible with a weakly coupled QGP in the early stage and end with values compatible with the hadronic result in the final state. We show that the loss of the signal occurs at the same time as hadronization and trace it back to the dynamical recombination process implemented in our model.
A generic-level phylogenetic review of the Macrodactylini (Coleoptera: Scarabaeidae: Melolonthinae)
(2007)
A revision of the generic classification of the tribe Macrodactylini is provided using morphological characters of adults. The revision is based on a taxonomic analysis of 80 genera historically placed in the tribe and a cladistic analysis of 32 genera conforming to the new tribal definition. Synapomorphies for the newly defined Macrodactylini include: the length of the fifth ventrite longer than the fourth ventrite when viewed ventrally, fifth ventrite lacking a complete suture between the tergite and sternite, and the metathoracic tibial spurs (if present) offset, allowing the metatarsus to move past them. Thirty-two genera constitute the newly defined Macrodactylini: Agaocnemis Moser, Alvarinus Blanchard, Ancistrosoma Curtis, Anomonyx Saylor, Anoplosiagum Blanchard, Astaenosiagum Martínez, Barybas Blanchard, Calodactylus Blanchard, Ceraspis Le Peletier and Serville, Ceratolontha Arrow, Chariodactylus Moser, Chariodema Blanchard, Chremastodus Solier, Clavipalpus Laporte, Ctenotis Burmeister, Dasyus Le Peletier and Serville, Dicrania Le Peletier and Serville, Gama Blanchard, Gastrohoplus Moser, Hercitis Burmeister, Hieritis Burmeister, Isonychus Mannerheim, Issacaris Fairmaire, Macrodactylus Dejean, Manodactylus Moser, Manopus Laporte, Oedichira Burmeister, Pectinosoma Arrow, Plectris Le Peletier and Serville, Pristerophora Harold, Rhinaspis Perty, and Schizochelus Blanchard. Sixteen genera are removed or their removal is confirmed from the historical Macrodactylini: Coenonycha Horn, Dichelonyx Harris, and Gymnopyge Linell (to Dichelonychini), Homalochilus Blanchard, Homoliogenys Gutiérrez, Liogenys Guérin-Méneville, and Pacuvia Curtis (to Diplotaxini), Diphycerus Deyrolle and Fairmaire (to Diphycerini), Hyperius Deyrolle and Fairmaire (to Melolonthini), Apterodemidea Gutiérrez (to Sericoidini), Blepharotoma Blanchard (to Liparetrini ), Diaphylla Erichson (removed from Macrodactylini, and currently unplaced into existing melolonthine tribes), Hilarianus Blanchard, Manonychus Moser, Pseudoisonychus Frey (removed from Macrodactylini, and currently unplaced into existing melolonthine tribes) and Zabacana Saylor (to Epectinaspis (Rutelinae)). Nine new generic synonyms are proposed: Corminus Burmeister, junior synonym of Alvarinus Blanchard; Ctilocephala Burmeister, Eubarybas Gutiérrez, and Pseudohercitis Moser, each a junior synonym of Barybas Blanchard; Byrasba Harold, Rhinaspoides Moser, and Ulomenes Blanchard, each a junior synonym of Rhinaspis Perty; Demodema Blanchard, a junior synonym of Plectris Le Peletier and Serville; and Pachylotoma Blanchard, junior synonym of Gama Blanchard.
The seven genera and 13 species of dynastine scarabs recorded from the Bahamas are reviewed. Two of those species are endemic, including Cyclocephala dolichotarsa Ratcliffe and Cave, new species, described from Great Inagua Island. Eleven species are also known to occur in the USA and/or Cuba. Six species are probably not established based on infrequency of collection.
New South American taxa of Odontolochini Stebnicka and Howden (Coleoptera: Scarabaeidae: Aphodiinae)
(2007)
Recently discovered Neotropical taxa belonging in the tribe Odontolochini Stebnicka and Howden (Coleoptera: Scarabaeidae: Aphodiinae) are described. New genera are: Amerilochus, type species Amerilochus cinereus, new species; and Stebnickiella, type species Stebnickiella zosterixys, new species. Three additional new species are: Saprolochus lobatus, Saprolochus tridentatus, and Saprositellus kenodontus. Updated keys are presented to the New World genera of Odontolochini as well as keys to species in the genera Saprolochus Stebnicka and Galante and Saprositellus Balthasar. New country records are presented for Saprositellus ariquemes Stebnicka.
This preliminary checklist of Aphodiini south of the United States is prepared to provide published data for a future web-based checklist of all New World Aphodiinae. All species names are used in combination with their currently accepted generic name, creating many new combinations. A few genus-species combinations are discussed. New synonymies based on recent studies of type specimens are made: Aphodius azteca Harold = Aphodius multimaculosus Hinton; Aphodius ornatus Schmidt = Aphodius magnopunctatus Hinton; Aphodius caracaensis Petrovitz = Aphodius brasilicola Balthasar; Aphodius guatemalensis Bates = Aphodius striatipennis Petrovitz; Aphodius kuntzeni Schmidt = Aphodius amplinotum Gordon and Howden = Aphodius michiliensis Deloya; Aphodius bimaculosus Schmidt = Aphodius xalapensis Galante et al.; Aphodius caracanus Balthasar = Aphodius martinsi Petrovitz; Aphodius volxemi Harold = Aphodius squamifer Petrovitz.
Habronyx Foerster occurs in all regions except the Afrotropical and parasitizes lepidopterous larvae (Geometridae, Noctuidae, Saturniidae, Sphingidae, Psychidae). Habronyx albifrons (Spinola) inhabits neantartic Chile and southern Argentina. It is black with a white flagellar annulus and with a strong prepectal carina on the lower half of the mesopleuron. Habronyx albifrons is redescribed and descriptions are given of two new species which belong to a group of their own: Habronyx citrinus Porter, n. sp., from central Chile; and Habronyx punensis Porter, n. sp., from the high Andean steppe of Bolivia, where it attacks noctuid larvae on Chenopodium quinoa Willd. These differ from H. albifrons because the prepectal carina is absent on the mesopleuron, being developed only on the mesosternum, and because they have the flagellum uniformly black and the gaster extensively orange. Habronyx punensis differs from H. citrinus in having a sharp carina on the front, the mesopleural punctures not reticulately confluent, the discoidella weaker and in part desclerotized
The naturalist Edward Newman did not provide an etymology for the mecopteran Merope tuber when he described it in 1838. In 1872 Asa Fitch asserted that the genus was named after Merope one of the Pleiades sisters of Greek mythology; however, he provided no reason for his assumption. We researched several etymological alternatives. We concur with Fitch and conclude that Newman did indeed name the genus Merope after the dullest of the Pleiades sisters.
Nomenclatural errors associated with the nymphalid butterfly, Speyeria atlantis greyi Moeck, have persisted in the literature and electronic databases. We present here a synonymy of the various combinations and misspellings associated with it and clearly indicate the correct name and spelling based on Moecks (1950) original description. Additionally, color images of the holotype and allotype specimens are published herein for the first time.
The genus name Drepanocanthoides Schmidt has recently been applied to Australian and North American taxa, based on generic concepts following separate designations of different type species. Drepanocanthoides, type species Aphodius walshii Horn, is a Nearctic genus that is not congeneric with the Australian members. The new name Ozodius, n. gen., is here proposed for the Australian taxa, with Aphodius neglectus Schmidt designated as the type species. All Australian members of Drepanocanthoides are transferred to Ozodius.
Agathymus escalantei Stallings, Turner, and Stallings, 1966 (Lepidoptera: Hesperiidae) is the only described species of Megathyminae known from a single collected individual. To date, the only images of this specimen are poor black and white illustrations published in the original description. This note presents the first color photographs of the holotype.
The distribution and biology of the beetles Leptinillus validus (Horn) and L. aplodontiae Ferris are summarized for North America. The beetles are ectoparasitic on rodents; L. validus on the beaver, Castor canadensis Linnaeus (Castoridae) throughout the northern part of its range, and L. aplodontiae on the mountain beaver, Aplodontia rufa (Rafinesque) (Aplodontidae) in the Pacific Northwest.
Mutual grooming in two genera of silvanid beetles is described, and appears to be the first report of this behavior in the order Coleoptera. In Uleiota debilis (LeConte), allogrooming recipients were either stationary or moved away during the acts, without solicitation or facilitation. In Nausibius major Zimmermann, allogrooming was much more extensive and the individual being groomed appeared to facilitate the process by immobility or by changes in posture, there were no recognizable sexual overtones, no solicitations, and no avoidance movements. Gregarious behaviors of some other silvanid beetles are reviewed.
Three distinct tibial types are recognized within the Rhyparini (Scarabaeidae, Aphodiinae). Based on this, generic limits for the species of Termitodius Wasmann are reevaluated, with the Old World members being transferred to Termitodiellus Nakane. The resulting new combinations are: Termitodiellus besucheti (Paulian), Termitodiellus hammondi (Krikken and Huijbregts), Termitodiellus interruptus (Krikken and Huijbregts), Termitodiellus luzonensis (Howden), Termitodiellus monticola (Krikken and Huijbregts). New World members of Termitodius are split into two genera: Termitodius Wasmann and Aschnarhyparus Makhan. Aschnarhyparus soesilae Makhan is here relegated to a junior synonym of Termitodius peregrinus Hinton, new synonymy, with the resulting new combination being Aschnarhyparus peregrinus (Hinton). A full description of Aschnarhyparus is presented, and Termitodiellus and Termitodius are diagnosed.
A new species of Physoconops Szilady, P. (Pachyconops) weemsi, is described from Florida and Georgia. It is similar to two other species in the southeastern United States, P. floridanus Camras and P. brachyrhynchus Macquart, the main differential character being the shape of the female theca. The female thecae for all three are illustrated and a key to the three related Pachyconops species occurring in the southeastern United States is presented.
New locality records for Culiseta inornata (Williston) are reported from Big Pine Key, Grassy Key, and No Name Key in Monroe County, Florida. Five specimens were collected in dry ice-baited light traps. An old, previously unrecognized record for Anopheles grabhamii Theobald from Miami, Dade County, Florida, is reported based on specimens found in the Florida State Collection of Arthropods.
The aim of this paper is to validate a dataset collected by means of production experiments which are part of the Questionnaire on Information Structure. The experiments generate a range of information structure contexts that have been observed in the literature to induce specific constructions. This paper compares the speech production results from a subset of these experiments with specific claims about the reflexes of information structure in four different languages. The results allow us to evaluate and in most cases validate the efficacy of our elicitation paradigms, to identify potentially fruitful avenues of future research, and to highlight issues involved in interpreting speech production data of this kind.
This paper surveys a range of constructions in which prosody affects discourse function and discourse structure.We discuss English tag questions, negative polar questions, and what we call “focus” questions. We postulate that these question types are complex speech acts and outline an analysis in Segmented Discourse Representation Theory (SDRT) to account for the interactions between prosody and discourse.
While the Information Structure (IS) is most naturally interpreted as "structure of information", some may argue that it is structure of something else, and others may object to the use of the word "structure". This paper focuses on the question of whether the informational component can have structural properties such that it can be called "structure". The preliminary conclusion is that, althoughthere are some vague indications of structurehood in it, it is perhaps better understood to be a representation that encodes a finite set of information-based partitions, rather than structure.
This paper presents the results of a production experiment on the intonation of sentences containing a negative polarity item (NPI) in Tokyo Japanese. The results show that NPI sentences exhibit a focus intonation: the F0-peak of the word to which an NPI is attached is raised, while the pitch contour after the NPI-attached word is compressed until the negation. This intonation pattern is parallel to that of wh-question, in which the F0 of the wh-phrase is raised while the post-wh-contour is compressed until the question particle.
Three dimensions can be distinguished in a cross-linguistic account of information structure. First, there is the definition of the focus constituent, the part of the linguistic expression which is subject to some focus meaning. Second and third, there are the focus meanings and the array of structural devices that encode them. In a given language, the expression of focus is facilitated as well as constrained by the grammar within which the focus devices operate. The prevalence of focus ambiguity, the structural inability to make focus distinctions, will thus vary across languages, and within a language, across focus meanings.
This paper discusses how focus change s prosodic structure in Tokyo Japanese. It is generally believed that focus blocks the intonational process of downstep and causes a pitch reset. This paper presents experimental evidence against this traditional view by looking at the prosodic behavior of Wh words, which receive focus lexically in Japanese as in other languages. It is demonstrated, specifically, that the focused Wh element does not block downstep although it receives a much higher pitch than its preceding element. This suggests that presence of lexical focus does not trigger pitch reset in Japanese.
Prosodic focus in Vietnamese
(2007)
This paper reports on pilot work on the expression of Information Structure in Vietnamese and argues that Focus in Vietnamese is exclusively expressed prosodically: there are no specific focus markers, and the language uses phonology to express intonational emphasis in similar ways to languages like English or German. The exploratory data indicates that (i) focus is prosodically expressed while word order remains constant, (ii) listeners show good recoverability of the intended focus structure, and (iii) that there is a trading relationship between several phonetic parameters (duration, f0, amplitude) involved to signal prosodic (acoustic) emphasis.
Phonology and intonation
(2007)
The encoding standards for phonology and intonation are designed to facilitate consistent annotation of the phonological and intonational aspects of information structure, in languages across a range ofprosodic types. The guidelines are designed with the aim that a nonspecialist in phonology can both implement and interpret the resulting annotation.
This article takes stock of the basic notions of Information Structure (IS). It first provides a general characterization of IS — following Chafe (1976) — within a communicative model of Common Ground (CG), which distinguishes between CG content and CG management. IS is concerned with those features of language that concern the local CG. Second, this paper defines and discusses the notions of Focus (as indicating alternatives) and its various uses, Givenness (as indicating that a denotation is already present in the CG), and Topic (as specifying what a statement is about). It also proposes a new notion, Delimitation, which comprises contrastive topics and frame setters, and indicates that the current conversational move does not entirely satisfy the local communicative needs. It also points out that rhetorical structuring partly belongs to IS.
New evidence is provided for a grammatical principle that singles out contrastive focus (Rooth 1996; Truckenbrodt 1995) and distinguishes it from discourse-new “informational” focus. Since the prosody of discourse-given constituents may also be distinguished from discourse-new, a three-way distinction in representation is motivated. It is assumed that an F-feature marks just contrastive focus (Jackendoff 1972, Rooth 1992), and that a G-feature marks discoursegiven constituents (Féry and Samek-Lodovici 2006), while discoursenew is unmarked. A crucial argument for G-marking comes from second occurrence focus (SOF) prosody, which arguably derives from a syntactic representation where SOF is both F-marked and G-marked. This analysis relies on a new G-Marking Condition specifying that a contrastive focus may be G-marked only if the focus semantic value of its scope is discourse-given, i.e. only if the contrast itself is given.
Contrastive focus
(2007)
The article puts forward a discourse-pragmatic approach to the notoriously evasive phenomena of contrastivity and emphasis. It is argued that occurrences of focus that are treated in terms of "contrastive focus", "kontrast" (Vallduví & Vilkuna 1998) or "identificational focus" (É. Kiss 1998) in the literature should not be analyzed in familiar semantic terms like introduction of alternatives or exhaustivity. Rather, an adequate analysis must take into account discourse-pragmatic notions like hearer expectation or discourse expectability of the focused content in a given discourse situation. The less expected a given content is judged to be for the hearer, relative to the Common Ground, the more likely a speaker is to mark this content by means of special grammatical devices, giving rise to emphasis.
We argue that the standard focus theories reach their limits when confronted with the focus systems of the Chadic languages. The backbone of the standard focus theories consists of two assumptions, both called into question by the languages under consideration. Firstly, it is standardly assumed that focus is generally marked by stress. The Chadic languages, however, exhibit a variety of different devices for focus marking. Secondly, it is assumed that focus is always marked. In Tangale, at least, focus is not marked consistently on all types of constituents. The paper offers two possible solutions to this dilemma.
Focus expressions in Foodo
(2007)
This paper aims at presenting different ways of expressing focus in Foodo, a Guang language. We can differentiate between marked and unmarked focus strategies. The marked focus expressions are first syntactically characterized: the focused constituent is in sentence-initial position and is second always marked obligatorily by a focus marker, which is [...] for non-subjects and N for subjects. Complementary to these structures, Foodo knows an elliptic form consisting of the focused constituent and a predication marker [...]. It will be shown that the two focus markers can be analyzed as having developed out of the homophone conjunction n[...] and that the constraints on the use of the focus markers can be best explained by this fact.
Focus presuppositions
(2007)
This paper reviews notions related to focus and presupposition and addresses the hypothesis that focus triggers an existential presupposition. Presupposition projection behavior in certain examples appears to favor a presuppositional analysis of focus. It is argued that these examples are open to a different analysis using givenness theory. Overall, the analysis favors a weak semantics for focus not including an existential presupposition.
Human manual action exhibits a differential use of a non-dominant (typically, left) and a dominant (typically, right) hand. Human communication exhibits a pervasive structuring of utterances into topic and comment. I will point out striking similarities between the coordination of hands in bimanual actions, and the structuring of utterances in topics and comments. I will also show how principles of bimanual coordination influence the expression of topic/comment structure in sign languages and in gestures accompanying spoken language, and suggest that bimanual coordination might have been a preadaptation of the development of information structure in human communication.
The aim of this paper is to outline the means for encoding information structure in Yucatec Maya. Yucatec Maya is a tone language, displaying a three-fold opposition in the tonal realization of syllables. From the morpho-syntactic point of view, the grammar of Yucatec Maya contains morphological (topic affixes, morphological marking of out-of-focus predicates) and syntactic (designated positions) means to uniquely specify syntactic constructions for their information structure. After a descriptive overview of these phenomena, we present experimental evidence which reveals the impact of the nonavailability of prosodic alternatives on the choice of syntactic constructions in language production.
In a first step, definitions of the irreducible information structural categories are given, and in a second step, it is shown that there are no invariant phonological or otherwise grammatical correlates of these categories. In other words, the phonology, syntax or morphology are unable to define information structure. It is a common mistake that information structural categories are expressed by invariant grammatical correlates, be they syntactic, morphological or phonological. It is rather the case that grammatical cues help speaker and hearer to sort out which element carries which information structural role, and only in this sense are the grammatical correlates of information structure important. Languages display variation as to the role of grammar in enhancing categories of information structure, and this variation reflects the variation found in the ‘normal’ syntax and phonology of languages.
The paper investigates focus marking devices in the scarcely documented North-Ghanaian Gur language Konkomba. The two particles lé and lá occur under specific focus conditions and are therefore regarded as focus markers in the sparse literature. Comparing the distribution and obligatoriness of both alleged focus markers however, I show that one of the particles, lé, is better analyzed as a connective particle, i.e. as a syntactic rather than as a genuine pragmatic marker, and that comparable syntactic focus marking strategies for sentence-initial constituents are also known from related languages.
The recognition of the prosodic focus position in German-learning infants from 4 to 14 months
(2007)
The aim of the present study was to elucidate in a study with 4-, 6-, 8-, and 14-month-old German-learning children, when and how they may acquire the regularities which underlie Focus-to-Stress Alignment (FSA) in the target language, that is, how prosody is associated with specific communicative functions. Our findings suggest, that 14-month-olds have already found out that German allows for variable focus positions, after having gone through a development which goes from a predominantly prosodically driven processing of the input to a processing where prosody interacts more and more with the growing lexical and syntactic knowledge of the child.
This paper deals with the conditions under which singular definites, on the one hand, and universally quantified DPs, on the other hand, receive interpretations according to which the sets denoted by the NP-complements of the respective determiner vary with the situations quantified over by a Q-adverb. I show that in both cases such interpretations depend on the availability of situation predicates that are compatible with the presuppositions associated with the respective determiner, as co-variation in both cases comes about via the binding of a covert situation variable that is contained within the NP-complement of the respective determiner. Secondly, I offer an account for the observation that the availability of a co-varying interpretation is more constrained in the case of universally quantified DPs than in the case of singular definites, as far as word order is concerned. This is shown to follow from the fact that co-varying definites in contrast to universally quantified DPs are inherently focus-marked.
When we pay close attention to the prosody of Wh-questions in Japanese, we discover many novel and interesting empirical puzzles that would require us to devise a much finer syntactic component of grammar. This paper addresses the issues that pose some problems to such an elaborated grammar, and offers solutions, making an appeal to the information structure and sentence processing involved in the interpretation of interrogative and focus constructions.
The paper explicates the notions of topic, contrastive topic, and focus as used in the analysis of Hungarian. Based on distributional criteria, topic and focus are claimed to represent distinct structural positions in the left periphery of the Hungarian sentence, associated with logical rather than discourse functions. The topic is interpreted as the logical subject of predication. The focus is analyzed as a derived main predicate, specifying the referential content of the set denoted by the backgrounded post-focus section of the sentence. The exhaustivity associated with the focus and the existential presupposition associated with the background are shown to be properties following from their specificational predication relation.
The Conference on Computational Natural Language Learning features a shared task, in which participants train and test their learning systems on the same data sets. In 2007, as in 2006, the shared task has been devoted to dependency parsing, this year with both a multilingual track and a domain adaptation track. In this paper, we define the tasks of the different tracks and describe how the data sets were created from existing treebanks for ten languages. In addition, we characterize the different approaches of the participating systems, report the test results, and provide a first analysis of these results.
Recent approaches to Word Sense Disambiguation (WSD) generally fall into two classes: (1) information-intensive approaches and (2) information-poor approaches. Our hypothesis is that for memory-based learning (MBL), a reduced amount of data is more beneficial than the full range of features used in the past. Our experiments show that MBL combined with a restricted set of features and a feature selection method that minimizes the feature set leads to competitive results, outperforming all systems that participated in the SENSEVAL-3 competition on the Romanian data. Thus, with this specific method, a tightly controlled feature set improves the accuracy of the classifier, reaching 74.0% in the fine-grained and 78.7% in the coarse-grained evaluation.
Prepositional phrase (PP) attachment is one of the major sources for errors in traditional statistical parsers. The reason for that lies in the type of information necessary for resolving structural ambiguities. For parsing, it is assumed that distributional information of parts-of-speech and phrases is sufficient for disambiguation. For PP attachment, in contrast, lexical information is needed. The problem of PP attachment has sparked much interest ever since Hindle and Rooth (1993) formulated the problem in a way that can be easily handled by machine learning approaches: In their approach, PP attachment is reduced to the decision between noun and verb attachment; and the relevant information is reduced to the two possible attachment sites (the noun and the verb) and the preposition of the PP. Brill and Resnik (1994) extended the feature set to the now standard 4-tupel also containing the noun inside the PP. Among many publications on the problem of PP attachment, Volk (2001; 2002) describes the only system for German. He uses a combination of supervised and unsupervised methods. The supervised method is based on the back-off model by Collins and Brooks (1995), the unsupervised part consists of heuristics such as ”If there is a support verb construction present, choose verb attachment”. Volk trains his back-off model on the Negra treebank (Skut et al., 1998) and extracts frequencies for the heuristics from the ”Computerzeitung”. The latter also serves as test data set. Consequently, it is difficult to compare Volk’s results to other results for German, including the results presented here, since not only he uses a combination of supervised and unsupervised learning, but he also performs domain adaptation. Most of the researchers working on PP attachment seem to be satisfied with a PP attachment system; we have found hardly any work on integrating the results of such approaches into actual parsers. The only exceptions are Mehl et al. (1998) and Foth and Menzel (2006), both working with German data. Mehl et al. report a slight improvement of PP attachment from 475 correct PPs out of 681 PPs for the original parser to 481 PPs. Foth and Menzel report an improvement of overall accuracy from 90.7% to 92.2%. Both integrate statistical attachment preferences into a parser. First, we will investigate whether dependency parsing, which generally uses lexical information, shows the same performance on PP attachment as an independent PP attachment classifier does. Then we will investigate an approach that allows the integration of PP attachment information into the output of a parser without having to modify the parser: The results of an independent PP attachment classifier are integrated into the parse of a dependency parser for German in a postprocessing step.
The renowned Grimm Dictionary (1854-1961) makes the statement that the German copula sein (to be) is “the most general and colourless of all verbal concepts” (der allgemeinste und farbloseste aller verbalbegriffe). A more concise summary of the linguistic issues surrounding the copula is hardly possible. These two properties (and the latent tension between them!) make copulas a particularly interesting and vexing subject of linguistic research. Copulas appear to be almost colourless, i.e., devoid of any concrete meaning, thus leading to the question of why such expressions exist at all, not only in German but in the majority of the world’s languages. And at the same time copulas presumably provide the best window into the core of verbal concepts thereby telling us what it actually means to be a verb – at least in a language like German or English. While there is a rather rich body of research on copulas in philosophical and formal semantics including several in-depth studies on the copular systems of individual languages, copulas have received comparably little attention from a typological perspective. The monograph of Regina Pustet sets out to fill this gap. She presents an extensive cross-linguistic study of copula usage based on a sample of 154 languages drawn from the language families of the world. The analysis is embedded in the theoretical framework of functional typology. The study aims at uncovering universal principles that govern the distribution of copulas in nominal, adjectival, and verbal predications. Its major objective is the development of a “semantically-based model of copula distribution” (p.62) by means of which the presence vs. absence of copulas can be motivated through the inherent meaning of the lexical items they potentially combine with. Drawing mainly on the work by Givón (1979, 1984) and Croft (1991, 2001), who provide a functional foundation of the traditional parts of speech, Pustet identifies four semantic parameters which, if taken together, are claimed to support substantial generalisations on copula distribution – within a given language as well as crosslinguistically. These parameters are DYNAMICITY, TRANSIENCE, TRANSITIVITY, and DEPENDENCY. Pustet goes on to argue – and this is in fact the driving force behind the overall monograph – that the distributional behaviour of copulas, in turn, yields a useful methodology for developing a general approach to lexical categorization. Thus, in the long run Pustet aims at contributing to a better understanding of the traditional parts of speech, noun, adjective, and verb by defining them in terms of “semantic feature bundles, which can be arranged in [a] coherent semantic similarity space” (p.193).
We investigate methods to improve the recall in coreference resolution by also trying to resolve those definite descriptions where no earlier mention of the referent shares the same lexical head (coreferent bridging). The problem, which is notably harder than identifying coreference relations among mentions which have the same lexical head, has been tackled with several rather different approaches, and we attempt to provide a meaningful classification along with a quantitative comparison. Based on the different merits of the methods, we discuss possibilities to improve them and show how they can be effectively combined.
The habitat requirements of most Aradidae and the decisive factors that influence their occurrence are still poorly understood. To reduce this lack of knowledge a standardised survey of Aradidae in two large beech forest areas of Bavaria (northern Steigerwald and High Spessart) was conducted. The following hypotheses were tested: 1) With increasing habitat tradition (temporal continuity), population densities of Aradidae increase, 2) Increasing dead wood supply supports higher abundance of Aradidae, 3) There are key structures for particular species with respect to type of dead wood, diameter and exposure to sunlight, and 4) The occurrence of particular fungi species determines the occurrence of Aradidae. In our study, Aradidae were sampled in point sample plots by flight-interception traps and time-standardised hand collection. To analyse specific habitat requirements additional sampling was performed to increase the sample size. Four species of Aradidae were observed in the two forest areas: Aneurus avenius, Aradus betulae, A. conspicuus and A. depressus. The results demonstrate that all species have different and specific habitat requirements. Especially for A. betulae habitat tradition of standing dead wood of large dimensions infested by Fomes fomentarius seems to be crucial. Hence, A. betulae was only observed in the Spessart and only at the sites with habitat tradition.
This paper presents an LTAG analysis of reflexives like himself and reciprocals like each other. These items need to find a c-commanding antecedent from which they retrieve (part of) their own denotation and with which they syntactically agree. The relation between anaphoric item and antecendent must satisfy the following important locality conditions (Chomsky (1981)).
The goal of this paper is to re-examine the status of the condition in (1) proposed in Alexiadou and Anagnostopoulou (2001; henceforth A&A 2001), in view of recent developments in syntactic theory. (1) The subject-in-situ generalization (SSG) By Spell-Out, vP can contain only one argument with a structural Case feature. We argue that (1) is a more general condition than previously recognized, and that the domain of its application is parametrized. More specifically, based on a comparison between Indo-European (IE) and Khoisan languages, we argue that (1) supports an interpretation of the EPP as a general principle, and not as a property of T. Viewed this way, the SSG is a condition that forces dislocation of arguments as a consequence of a constraint on Case checking.
High-performance liquid chromatography (HPLC) has proved extremely versatile over the past 25 yr for the isolation and punfication of peptides varying widely in their sources, quantity and complexity. This article covers the major modes of HPLC utilized for peptides (size-exclusion, ion-exchange, and reversed-phase), as well as demonstrating the potential of a novel mixed-mode hydrophilic interaction/cation-exchange approach developed in this laboratory. In addition to the value of these HPLC modes for peptide separations, the value of various HPLC techniques for structural characterization of peptides and proteins will be addressed, e.g., assessment of oligomerization state of peptideslproteins by sizeexclusion chromatography and monitoring the hydrophilicitykydrophobicity of amphipathic cr-helical peptides, a vital precursor Tor the development of novel antimicrobial peptides. The value of capillary electrophoresis for peptide separations is also demonstrated. Preparative reversed-phase chromatography purification protocols for sample loads of up to 200 mg on analytical columns and instrumentation are introduced for both peptides and recombinant proteins. Key Words: Peptides; proteins; size-exclusion chromatography (SEC); anion-exchange chromatography (AEX); cation-exchange chromatography (CEX); mixed-mode hydrophilic interaction chromatography (HIL1C)/cation-exchange chromatography (CEX); reversed-phase high-performance liquid chromatography (RP-HPLC); preparative RP-HPLC of peptides and proteins; amino acid side-chain hydrophilicitylhydrophobicity coefficients; amino acid U-helical propensity values; amino acid side-chain stability coefficients
I. Introduction The early 1970s in the United States was a turbulent, rebellious period – in which all questions were legitimate, certainly on the college campus. As the rabbinic advisor to the Orthodox minyan at Harvard-Radcliffe Hillel, I found myself challenged repeatedly by congregants, colleagues and friends regarding the status of women in Jewish law and ritual. This required me, in turn, to search for honest and appropriate explanations and rationale. This quest has continued to preoccupy me for more than three decades. When I first embarked on this endeavor, I did so with a sense of confidence and commitment. As a “Halakhic Feminist,” I have searched for ways to increase women’s involvement in Jewish spiritual and ritual life, and I remain confident in the inherent viability of the halakhic process. But through it all, my highest commitment has been to the integrity of Halakhah. I firmly believe that without Halakhah as our anchor, we would rapidly lose our direction and raison d’etre.Because of these sensitivities, I picked up Tamar Ross’s recent book “Expanding the Palace of Torah: Orthodoxy and Feminism” with a great deal of excitement and anticipation. The author comes with wonderful credentials: she is an esteemed professor of philosophy, a traditional Jewess, and a highly respected Orthodox feminist. Academically, this extremely analytical, insightful, erudite and welldocumented book turned out to be highly challenging because of its interdisciplinary nature, saturated with new jargon and concepts. But it was by no means disappointing. Indeed, more than 300 pages later, I found myself intellectually edified and stimulated by my newfound understanding of the history, philosophy and theology of feminism. Prof. Ross is quite effective at outlining many of the troubling issues concerning the status of women in Jewish law – issues that every thinking, committed Jew should ponder. As a result, this work has received generally laudatory reviews. Despite all the above, I found the book very unsettling. In her preface (p. xvii), the author indicates that, in addition to scholars of religion and feminism, this book is directed to two other audiences. The first group includes those who have been sensitized by feminism but are desirous of keeping their grip on tradition. The second audience consists of those who are firmly Orthodox, but would like to gain greater insight into what the feminist fuss is all about.5 In short, as the title ofthe book suggests, Prof. Ross attempts to span the divide between Orthodoxy and feminism. Unfortunately, I do not believe she has succeeded in this task, and this essay is an attempt to delineate why.
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues. Infectious leptospires are resistant to killing by their hosts' alternative pathway of complement-mediated killing, and interact with various host extracellular matrix (ECM) components. The LenA outer surface protein (formerly called LfhA and Lsa24) was previously shown to bind the host ECM component laminin and the complement regulators factor H and factor H-related protein-1. We now demonstrate that infectious L. interrogans contain five additional paralogs of lenA, which we designated lenB, lenC, lenD, lenE and lenF. All six genes encode domains predicted to bear structural and functional similarities with mammalian endostatins. Sequence analyses of genes from seven infectious L. interrogans serovars indicated development of sequence diversity through recombination and intragenic duplication. LenB was found to bind human factor H, and all of the newly-described Len proteins bound laminin. In addition, LenB, LenC, LenD, LenE and LenF all exhibited affinities for fibronectin, a distinct host extracellular matrix protein. These characteristics suggest that Len proteins together facilitate invasion and colonization of host tissues, and protect against host immune responses during mammalian infection.
End-stage renal disease has been denominated a vasculopathic state, owing to the accelerated arterial stiffening, which occurs in addition to and independent of atherosclerosis and bears an increased cardiovascular risk. The altered metabolic milieu in uraemia leads to an increased oxidative stress, heightened inflammatory burden, and an abnormal calcium-phosphate metabolism, which are thought to be responsible for the vascular changes. The pulse wave velocity (PWV) is a widely employed surrogate parameter of arteriosclerosis. The purpose of this study was to gain more insight into the pathogenesis of arterial stiffness, by investigating the influence of markers of oxidative stress, procoagulation, and inflammation, and of the calcium-phosphate product on the PWV. We conducted a cross-sectional study in 53 stable patients aged 59 ± 16 years, who had been on haemodialysis for at least 4 months (68 ± 48). Carotid-radial PWV was measured using a semi-automated device, Complior SP (Artech Medical, France). Advanced glycosylation end-products (AGE) and advanced oxidation protein products (AOPP), were quantified according to previously described methods. High sensitive CRP was measured using ELISA, whereas the other biochemical parameters, i.e. fibrinogen, albumin, calcium, phosphate, cholesterol, and triglycerides, were determined using routine methods. For statistical calculations we employed SPSS (Statistical Package of Social Science, 12.0, 2003). The correlations between PWV, as the dependent variable, and many dependent variables were assessed by means of multiple regression analysis, in which we controlled for the influence of the traditional cardiovascular risk factors and some of the patients’ medication (calcium-channel blockers and statins). PWV was found to be significantly correlated to serum CRP (p=0.003), LDLcholesterol (p<0.001), triglycerides (p<0.001), AGE (p=0.002), calcium (p<0.001), phosphate (p=0.001), and fibrinogen (p=0.020). Between PWV and dialysis duration (months) an interesting quadratic relationship (p=0.058) was noted. Against expectation, regression analysis showed a negative correlation between AOPP and PWV (p=0.001). We failed to confirm the correlation between PWV and age, systolic blood pressure, or heart rate. Among traditional cardiovascular risk factors only LDL-cholesterol was positively correlated to PWV. In this cross-sectional analysis we could put forward that PWV correlates positively and significantly with fibrinogen, CRP, AGEs, calcium, phosphate, and LDL-cholesterol in haemodialysis patients. It seems procoagulatory and proinflammatory pathways, oxidative stress, and the calcium-phosphate product exert a synergistic effect on disturbances of vascular architecture in ESRD patients.
The geometric parameters of the title compound, C8H6N2O·C6H3N3O7, are in the usual ranges. The three nitro groups are almost coplanar with the aromatic picrate ring [dihedral angles 10.2 (2)°, 7.62 (16) and 8.08 (17)°]. The molecular conformation of the picric acid is stabilized by an intramolecular O-H...O hydrogen bond. The phthalazin-1(2H)-one molecules are connected via N-H...O hydrogen bonds, forming centrosymmetric dimers. Key indicators: single-crystal X-ray study; T = 173 K; mean σ(C–C) = 0.002 Å; R factor = 0.034; wR factor = 0.091; data-to-parameter ratio = 11.1.
Intrinsic motivation, the causal mechanism for spontaneous exploration and curiosity, is a central concept in developmental psychology. It has been argued to be a crucial mechanism for open-ended cognitive development in humans, and as such has gathered a growing interest from developmental roboticists in the recent years. The goal of this paper is threefold. First, it provides a synthesis of the different approaches of intrinsic motivation in psychology. Second, by interpreting these approaches in a computational reinforcement learning framework, we argue that they are not operational and even sometimes inconsistent. Third, we set the ground for a systematic operational study of intrinsic motivation by presenting a formal typology of possible computational approaches. This typology is partly based on existing computational models, but also presents new ways of conceptualizing intrinsic motivation. We argue that this kind of computational typology might be useful for opening new avenues for research both in psychology and developmental robotics.
Summary The basal transcription apparatus of archaea is well characterized. However, much less is known about the mechanisms of transcription termination and translation initation. Recently, experimental determination of the 5´-ends of ten transcripts from Pyrobaculum aerophilum revealed that these are devoid of a 5´-UTR. Bioinformatic analysis indicated that many transcripts of other archaeal species might also be leaderless. The´-ends and 3´-ends of 40 transcripts of two haloarchaeal species, Halobacterium salinarum and Haloferax volcanii, have been determined. They were used to characterize the lengths of 5´-UTRs and 3´-UTRs and to deduce consensus sequence-elements for transcription and translation. The experimental approach was complemented with a bioinformatics analysis of the H. salinarum genome sequence. Furthermore, the influence of selected 5´-UTRs and 3´-UTRs on transcript stability and translational efficiency in vivo was characterized using a newly established reporter gene system, gene fusions, and real-time PCR. Consensus sequences for basal promoter elements could be refined and a novel element was discovered. A consensus motif probably important for transcriptional termination was established. All 40 haloarchaeal transcripts analyzed had a 3´-UTR (average size 57 nt), and their 3´-ends were not posttranscriptionally modified. Experimental data and genome analyses revealed that the majority of haloarchaeal transcripts are leaderless, indicating that this is the predominant mode for translation initiation in haloarchaea. Surprisingly, the 5´-UTRs of most leadered transcripts did not contain a Shine-Dalgarno (SD) sequence. A genome analysis indicated that less than 10% of all genes are preceded by a SD sequence and even most proximal genes in operons lack a SD sequence. Seven different leadered transcripts devoid of a SD sequence were efficiently translated in vivo, including artificial 5´-UTRs of random sequences. Thus, an interaction of the 5´-UTRs of these leadered transcripts with the 16S rRNA could be excluded. Taken together, either a scanning mechanism similar to the mechanism of translation initiation operating in eukaryotes or a novel mechanism must operate on most leadered haloarchaeal transcripts. Author Summary Expression of the information encoded in the genome of an organism into its phenotype involves transcription of the DNA into messenger RNAs and translation of mRNAs into proteins. The textbook view is that an mRNA consists of an untranslated region (5´-UTR), an open reading frame encoding the protein, and another untranslated region (3´-UTR). We have determined the 5´-ends and the 3´-ends of 40 mRNAs of two haloarchaeal species and used this dataset to gain information about nucleotide elements important for transcription and translation. Two thirds of the mRNAs were devoid of a 5´-UTR, and therefore the major pathway for translation initiation in haloarchaea involves so-called leaderless transcripts. Very unexpectedly, most leadered mRNAs were found to be devoid of a sequence motif believed to be essential for translation initiation in bacteria and archaea (Shine-Dalgarno sequence). A bioinformatic genome analysis revealed that less than 10% of the genes contain a Shine-Dalgarno sequence. mRNAs lacking this motif were efficiently translated in vivo, including mRNAs with artificial 5´-UTRs of total random sequence. Thus, translation initiation on these mRNAs either involves a scanning mechanism similar to the mechanism operating in eukaryotes or a totally novel mechanism operating at least in haloarchaea.
Contents - BIX: pole position and runner-up - Frankfurt University Library: its responsibilities, its collections, its databases, its supra-regional collecting responsibilities – and some statistics - The "Sondersammelgebiet" Germanistik: its scope and contents, its principal strengths, present situation, and budget - Sammlung Deutscher Drucke: the 1801-1870 segment of the "Distributed National Library" - Information Services: Bibliographie der deutschen Sprach- und Literaturwissenschaft (BDSL), Neuerwerbungsliste Germanistik, Bibliographie germanistischer Bibliographien (BgB), DigiZeitschriften, information bulletins - Work of the Subject Specialist: exhibitions, publicity material
Mesenchymal stem cells (MSC), also referred to as marrow stromal cells, maintain the capacity to differentiate into multiple mesenchymal lineages such as osteoblasts, chondrocytes, adipocytes, myoblasts, stromal, neural and endothelial cells. The use of autologous MSC has generated widespread interest due to their developing application in regenerative medicine and tissue engineering in orthopedic surgery. They have become an indispensable cell source for successful implementation in many bone reconstruction procedures. In addition to their multipotency and selfrenewal capacity, they are easily harvested, have demonstrated a homing mechanism and can be efficiently expanded in vitro, thus providing a safe and costefficient tissue replacement for patients with skeletal injury or disease. Little information is currently available concerning donor characteristics for tissue engineering growth of osseous tissue. This study examines the influences of such donor characteristics, including injury pattern, gender, age, and site of harvest on the quantity, quality and osteogenic differentiation of MSC. The goal is to evaluate whether certain patient groups are practically suitable for an ex vivo expansion and therapeutic reimplantation of MSC. The effect of injury pattern on the reservoir and proliferative capacity of MSC in human bone marrow is clearly demonstrated in this analysis. Age and gender were also shown to influence MSC number and proliferation, as in previous studies. A total of 53 participants (46 patients and 7 healthy volunteers ranging from 18 to 64 years of age), who were scheduled to undergo operative procedures on the pelvis, vertebrae, tibia or hip as well as cancellous bone autografts for reconstruction of various bone defects, were included in the study. Participants were divided into 4 groups for each gender: single fracture, multiple trauma, atrophic nonunion and healthy volunteers. A minimum of 6 ml bone marrow samples were aspirated intraoperatively and processed immediately according to protocol. Following cultivation and expansion for 14 days, the cells were then stained for the colony forming unit-fibroblast (CFU-F) assay and each culture flask was photographed, digitized and converted to an 8 bit grey level TIF-format. Using the digitized CFU-F assay, the mean colony number, mean colony area and mean cell number per microscopic field of view (cell density) could be determined. In addition, confirmation of MSC phenotype was established using fluorescent activated cell sorting (FACS). MSC potential for osteogenic differentiation was quantified by von Kossa, alkaline phosphatase and alizarin staining. Furthermore, serum from a total of 39 randomly chosen participants was collected and tested for hormone levels of 17β-estradiol, testosterone and prolactin as well as the cytokine interleukin-6. These analyses demonstrate several significant trauma-related modifications in MSC reservoir and proliferation, in both male and female patients. In multiple trauma patients, the highest MSC frequency was found, independent of gender and age. Proliferative capacity was also highest in male multiple trauma patients. In the case of atrophic nonunion, the lowest MSC reservoir was detected, independent of gender. Furthermore, MSC frequency in male patients was significantly higher than in female, although analyses of hormone and interleukin-6 levels provided no correlation. Agerelated changes in MSC reservoir could also be observed, whereas the proliferative capacity produced only a tendency toward decreasing values with increasing age. Concerning the site of cell harvest, MSC isolated from the proximal extremity of the tibia, greater trochanter and vertebral body did not proliferate sufficiently enough to be included in statistical analysis, supporting the use of the iliac crest for efficient expansion of MSC. This data suggests the interaction of yet to be identified processes in bone marrow in multiple trauma situations which stimulate the activation and mobilization of MSC. Moreover, in the case of atrophic nonunion, the concentration in bone marrow is depleted and the absence of systemic stimulation present in multiple trauma results in reduced activation of proliferative capacity. Such patients, with severe injury or atrophic nonunion, represent a group of patients with an especially acute necessity for effective and successful bone reconstruction. This data can be used to determine the applicability of MSC from various patient groups for osseous tissue replacement procedures. Especially in such medically challenging situations, further research is essential not only to delineate the factors involved in MSC regulation but also to develop methods to stimulate MSC expansion and proliferation.
Neuronal nAChRs are a diverse family of pentameric ion channels with wide distribution throughout cells of the nervous and immune systems. However, the role of specific subtypes in normal and pathological states remains poorly understood due to the lack of selective probes. Here, we used a binding assay based on acetylcholine-binding protein (AChBP), a homolog of the nicotinic acetylcholine ligand-binding domain, to discover a novel alpha-conotoxin (alpha-TxIA) in the venom of Conus textile. alpha-TxIA bound with high affinity to AChBPs from different species and selectively targeted the alpha3beta2 nAChR subtype. A co-crystal structure of Ac-AChBP with the enhanced potency analog TxIA(A10L), revealed a 20° backbone tilt compared to other AChBP–conotoxin complexes. This reorientation was coordinated by a key salt bridge formed between Arg5 (TxIA) and Asp195 (Ac-AChBP). Mutagenesis studies, biochemical assays and electrophysiological recordings directly correlated the interactions observed in the co-crystal structure to binding affinity at AChBP and different nAChR subtypes. Together, these results establish a new pharmacophore for the design of novel subtype-selective ligands with therapeutic potential in nAChR-related diseases.
Beethoven's Ninth in Bailey Hall the other evening, April 20, ending in an instant standing ovation by a clearly enchanted audience, was an unforgettable experience. And, like all such truly extraordinary events that are marked not only by artistic merit, but draw their power from the circumstances surrounding their creation or performance, it recalled others and enhanced their significance. I was reminded of a stellar performance on Christmas Day of 1989, only weeks after the unexpected fall of the Berlin Wall on November 9, that haunting date in German history. Few people believed it would ever happen. But now, suddenly, reunification in justice and freedom, as the truncated old national anthem phrases it, was within reach.
A systematic revision of the genus Dichaeu (Orchidaceae) in Costa Rica is presented. The taxonomic history of the genus and its phylogenetic position are discussed, with emphasis on infragenenc grouping. Characters of vegetative and floral morphology are treated, and their taxonoiilic significance is discussed. Twenty-nine Dichnea taxa are recognized for the flora of Costa Rica, and a key to species is provided. Each taxon is described on the basis of Costa Rican material, illustrated in a composite plate, and its distribution in the country is assessed. Distribution maps for all the taxa are given. Overall distribution, derivation of name, notes on species ecology, and diagnostic features are presented for each taxon. Lectotypes are selectcd for D. acostae Schltr., D. acroblephara Schltr., D. amparoana Schltr., D. costaricensis Schltr., D. dammeriana Kraenzl., D. lycopodioides Rchb. f. ex Kraenzl., D. poicillantha Schltr., D. selaginella Schltr., D. tuercklheimii Schltr., Epidendrum echinocarpon Sw., and E. trichocarpon Sw. A new species, D. gomez-lauritoi, is described and illustrated from the wet Caribbean plains of central Costa Rica.
The majority of cells are equipped to detect and decipher physical stimuli, and then react to these stimuli in a cell type-specific manner. Ultimately, these cellular behaviors are synchronized to produce a tissue response, but how this is achieved remains enigmatic. Here, we investigated the genetic basis for mechanotransduction using the bone marrow as a model system. We found that physical stimuli produced a pattern of principal strain that precisely corresponded to the site-specific expression of sox9 and runx2, two transcription factors required for the commitment of stem cells to a skeletogenic lineage, and the arrangement and orientation of newly deposited type I collagen fibrils. To gain insights into the genetic basis for skeletal mechanotransduction we conditionally inactivated focal adhesion kinase (FAK), an intracellular component of the integrin signaling pathway. By doing so we abolished the mechanically induced osteogenic response and thus identified a critical genetic component of the molecular machinery required for mechanotransduction. Our data provide a new framework in which to consider how physical forces and molecular signals are synchronized during the program of skeletal regeneration.
In this work we present a study of the influence of nucleus initializations on the event-by-event elliptic flow coefficient, v2. In most Monte-Carlo models, the initial positions of the nucleons in a nucleus are completely uncorrelated, which can lead to very high density regions. In a simple, yet more realistic model where overlapping of the nucleons is avoided, fluctuations in the initial conditions are reduced. However, v2 distributions are not very sensitive to the initialization choice.
Children […] growing up with highly inflected languages such as Modern Greek will frequently hear different grammatical forms of a given lexeme used in different grammatical and semantic-pragmatic contexts. In spite of the fact that the Greek noun is not as highly inflected as the verb, acquisition of nominal inflection of this inflecting-fusional language is quite complex, comprising the three categories of case, number, and gender. As is usual in this type of language, the formation of case-number forms obeys different patterns that apply to largely arbitrary classes of nominal lexemes partially based on gender. Further, frequency of the occurrence of the three gender classes and case-number forms of nouns greatly differs in spoken Greek, regarding both the types and tokens. […] [A] child learning an inflecting-fusional language like Greek must construct different inflectional patterns depending not only on parts of speech but also on subclasses within a given part of speech, such as gender classes of nouns and inflectional classes within or (exceptionally) across genders. It is therefore to be expected that the early development of case and number distinctions will apply to specific nouns and subclasses of nouns rather than the totality of Greek nouns. The two main theoretical approaches of morphological development that will be discussed in the present paper are the usage-based approach and the pre- and protomorphology approach.
Techniques for collecting, handling, preparing, storing and examining small molluscan specimens
(2007)
Micromolluscs are small-sized molluscs (< 5 mm), and include the great majority of undescribed molluscan taxa. Such species require special collecting, sorting and handling techniques and different storage requirements to those routinely used for larger specimens. Similarly, the preparation of shells, opercula, radulae and animals poses some challenges for scanning electron microscopy (SEM). An overview of experiences with various techniques is presented, both positive and negative. Issues discussed include those relating to storage of dry specimens and interaction of specimens with glass, gelatine and paper products, handling techniques and storage in various fluids. Techniques for cleaning shells for SEM are described and compared, as well as those for radular extraction. The interactions of chemicals used for the dissolution of tissue with calcareous micromolluscs are described. Methods for handling and mounting small radulae for SEM are detailed and brief guides to SEM and light photography are given. An appendix listing details of frequently-used chemicals is provided.
Semantic form as interface
(2007)
The term interface had a remarkable career over the past several decades, motivated largely by its use in computer science. Although the concept of a "surface common to two areas" (Oxford Advanced Learner's Dictionary, 1980) is intuitively clear enough, the range of its application is not very sharp and well defined, a "common surface" is open to a wide range of interpretations.
Beyond unpluggability
(2007)
We consider evidentials embedded in complement clauses with new data from Bulgarian. For Tibetan, Garrett has shown that embedded evidentials are always shifted to the perspective of the reported speech. In Bulgarian, we show that such a shift is almost never possible. This shows that Bulgarian evidentials should not be analyzed as modals, but rather as presuppositional.
Presupposition
(2007)
Compositionality
(2007)
Introduction
(2007)
The annotation guidelines introduced in this chapter present an attempt to create a unique infrastructure for the encoding of data from very different languages. The ultimate target of these annotations is to allow for data retrieval for the study of information structure, and since information structure interacts with all levels of grammar, the present guidelines cover all levels of grammar too. After introducing the guidelines, the current chapter also presents an evaluation by means of measurements of the inter-annotator agreement.
Traces
(2007)