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Structural biology and life sciences in general, and NMR in particular, have always been associated with advanced computing. The current challenges in the post-genomic era call for virtual research platforms that provide the worldwide research community with both user-friendly tools, platforms for data analysis and exchange, and an underlying e-Infrastructure. WeNMR, a three-year European Commission co-funded project started in November 2010, groups different research teams into a worldwide virtual research community. It builds on the established eNMR e-Infrastructure and its steadily growing virtual organisation, which is currently the second largest VO in the area of life sciences. WeNMR provides an e-Infrastructure platform and Science Gateway for structural biology. It involves researchers from around the world and will build bridges to other areas of structural biology.
Whereas in traditional models of literary narrative we had to deal with typologies mainly (for instance, of "narrative situations"; see Stanzel 1971, 1984; Fludernik and Margolin 2004; Genette 1980), we now possess a systematic description of the imagination evoked by a text, which takes into account the quasi-ontological (see Bortolussi and Dixon 2003) status of its constituents. In this chapter I search for the cognitive functions that correlate with the text features of "voice" and "perception" and for how they bring about such a "layered" imagination in the reader. The aim is to explain how and why literary narratives can run properly in the human mind-which is another way of asking how humans could develop narrative discourse as a way of communication at all.
In this brief excursion into the poetry of Dante and Montale, Rebecca West suggests some approaches to only a few issues that emerge out of the creation of both the primary beloveds of Dante and Montale and of those feminine figures that have been characterized as ostensibly 'antitranscendental' and more secondary in their roles and meanings. As regards Montale's primary feminine figure, Clizia, West argues that she is, to use Teodolinda Barolini's term for Beatrice, a 'hybrid' poetic character, and ultimately exceeds the limits of the poetic beloved as traditionally conceived and read, not only in the courtly tradition upon which she is modelled but well beyond it. In the case of the so-called secondary 'other women' in Dante's and Montale's poetry, West seeks to show that they are much less separable from the primary feminine figures than such binaries as major/minor, transcendent/erotic, soul/body, and traditional/experimental may lead us to believe. Lastly, West considers specifically the wife-figure, in her conspicuous absence from Dante's corpus and in her late appearance in Montale's. For both poets, there are complex intertwinings, interferences, and non-dualistic patterns that form a densely textured poetic weave, in which both the primary and the secondary feminine figures provide "fili rossi" as well as not so easily graspable dangling threads of meaning. These threads have to do with the preoccupation of both poets with the possible integration of immanence and transcendence, embodiment and abstraction, and with the very limits of poetic language. West's topic is also motivated by a feminist-oriented search for modes of deciphering the figure of the feminine beloved in lyric poetry that are not conditioned exclusively by the traditional emphasis on the male poet-creator, but which allow for a shift in focus onto the female figure who is, of course, the creature of the poet's imagination and skill, but who also often takes him into regions in which the excesses (commonly associated with the female) of non-binary thought and the mysteries of alterity - the feminine symbolic sphere, in short - do not so much allow the emergence of neatly squared-off meanings as the evolution of more oblique, circular conduits of potential significance. As a specialist of modern literature, Rebecca West concentrates on Montale more than on Dante, mainly noting the Dantesque aspects of the former's poetry.
Even if the title of Wolfgang Koeppen's last novel, "Der Tod in Rom", alludes quite obviously to Thomas Mann's novella, "Der Tod in Venedig", Koeppen's text must be understood first and foremost as a response to Mann's most controversial novel, "Doktor Faustus". The novels of Mann and Koeppen rank among the most well-known literary examinations of National Socialism but stand in a complementary relation to each other. "Doktor Faustus", published in 1947, analyses the cultural and intellectual origins of German fascism, while "Der Tod in Rom", published only seven years later in 1954, criticizes the continuity of National Socialist ideologies in post-war Germany. Both authors focus their analyses of fascism on fictional avant-garde composers who seem at first glance detached from any political context. [...] The actual starting point of Florian Trabert's paper, however, is the fact that both novels are preceded by epigraphs taken from Dante's "Inferno". Trabert begins by commenting on the references to Dante in "Doktor Faustus" and then continues by analysing the allusions to the "Commedia" in Koeppen's novel, which constitute, as Trabert demonstrates, a complex constellation among the three texts.
Dante's "Inferno" and Walter Benjamin's cities : considerations of place, experience, and media
(2011)
When Walter Benjamin wrote his main texts, the theme of the city as hell was extremely popular. Some of his German contemporaries, such as Brecht or Döblin, also used it. Benjamin was aware of these examples, as well as of examples outside Germany, including Joyce's "Ulysses" and Baudelaire's "poetry". And he was - at least in some way - familiar with Dante's "Inferno" and used it, and in particular Dante's conception of hell, for his own purposes. Benjamin's appropriation of the topos of the Inferno has been seen as a critique of capitalism and as a general critique of modernism by means of allegory. In the following analysis, Angela Merte-Rankin takes a slightly different approach and, despite Benjamin's status as an expert on allegory, considers hell in its literal sense as a place and examines the issues of implacement that might follow from this standpoint.
There has been a great deal of uproar about Darwinian approaches in literary scholarship. Statements range from enthusiastic prophecies of a new paradigm for literary studies to acrimonious scoldings of reductionism. Believing that the major challenge is first to find good questions to which evolutionary psychology might provide us with good answers, I outline and critically assess different veins of argumentation as revealed in recent contributions to the field. As an alternative to some simplistic mimeticism in present Literary Darwinism, I put forward the idea of evolutionary psychology as a heuristic theory that serves to resolve defined problems in interpretation and literary theory.
High grade gliomas, including anaplastic glioma WHO grade III and glioblastoma WHO IV (GBM), carry a dismal prognosis. Taking all nowadays-available therapeutics options, including radiation, chemotherapy and surgery, for GBM into consideration the prognosis after initial diagnosis is about 12 month. Despite this bad prognosis, researchers gained a tremendous insight into the molecular and genetic signatures of low and high grade gliomas. Several different subtypes of GBM were demonstrated with respect to their genetic background. These genetic alterations include p53 mutation in secondary GBMs and EGFR amplification in primary GBMs, respectively. Very recently, great excitement was raised after the discovery of IDH1 mutation in low-grade gliomas and secondary GBMs. This discovery is of great significance since it allows further categorizing of GBMs and is helpful in distinguishing low-grade gliomas from non-neoplastic adjacent brain tissue. Despite all this progress there is an urgent need for fresh additional therapeutic strategies. In addition to the identification of novel therapeutic regimens it is of utmost importance to gain an understanding about the molecular mechanisms on how GBMs manage to evade from almost any anti-cancer treatment regimen. In experimental models of glioblastoma there are a number of novel therapeutic regimens that exhibited promising results. These novel therapeutics include, but are not limited to: Apoptosis-based therapeutics (Tumor necrosis factor alpha related apoptosis inducing ligand, TRAIL), tyrosinkinase-inhibitors, Heat-shock-protein 90 (HSP90) inhibitors, polyphenols, novel drug combinations and intracranial application based strategies. This chapter will primarily review and focus on molecular mechanisms of resistance in GBM and rising new therapeutic venues for high-grade gliomas. High-grade gliomas are a group of primary heterogenous tumors of which glioblastoma World Health Organisation, WHO IV (GBM), is the most common one. Once the diagnosis of GBM is made, the average survival time is approximately 12-15 month (Hegi, Diserens et al., 2005). Treatment usually consists of temozolomide (commonly used chemotherapeutic drug for the treatment of GBM, TMZ), radiation (either alone or in combination with chemotherapeutics) and surgery (Hegi, Diserens et al., 2005)...
Application of the liposuction techniques and principles in specific body areas and pathologies
(2011)
The buttocks have been a symbol of attraction, sexuality and eroticism since ancient times and therefore, they have an important role in defining the posterior body contour. More and more people are talking about and understand the meaning and the role that buttocks play in modeling and physical beauty. The three dimensional gluteoplasty (3-DGP) is an innovative technique that allows us to change volume, shape and firmness, not only in the buttocks but also in the adjacent regions such as the thighs and trochanters, becoming an ideal tool to answer the frequent reasons of consultation of our patients about this particular area of the body: ...
Temporal regularity allows predicting the temporal locus of future information thereby potentially facilitating cognitive processing. We applied event-related brain potentials (ERPs) to investigate how temporal regularity impacts pre-attentive and attentive processing of deviance in the auditory modality. Participants listened to sequences of sinusoidal tones differing exclusively in pitch. The inter-stimulus interval (ISI) in these sequences was manipulated to convey either isochronous or random temporal structure. In the pre-attentive session, deviance processing was unaffected by the regularity manipulation as evidenced in three event-related-potentials (ERPs): mismatch negativity (MMN), P3a, and reorienting negativity (RON). In the attentive session, the P3b was smaller for deviant tones embedded in irregular temporal structure, while the N2b component remained unaffected. These findings confirm that temporal regularity can reinforce cognitive mechanisms associated with the attentive processing of deviance. Furthermore, they provide evidence for the dynamic allocation of attention in time and dissociable pre-attentive and attention-dependent temporal processing mechanisms.
This paper examines how questions, both Wh-questions and yes-no questions, are phrased in Chimwiini, a Bantu language spoken in southern Somalia. Questions do not require any special phrasing principles, but Wh-questions do provide much evidence in support of the principle Align-Foc R, which requires that focused or emphasized words/constituents be located at the end of a phonological phrase. Question words and enclitics are always focused and thus appear at the end of a phrase. Although questions do not require any new phrasing principles, they do display complex accentual (tonal) behavior. This paper attempts to provide an account of these accentual phenomena.
This paper presents a preliminary survey of the positions and prosodies associated with Wh-questions in two Bantu languages spoken in Malawi. The paper shows that the two languages are similar in requiring focused subjects to be clefted. Both also require 'which' questions and 'because of what' questions to be clefted or fronted. However, for other non-subjects Tumbuka rather uniformly imposes an IAV (immediately after the verb) requirement, while Chewa does not. In both languages, we found a strong tendency for there to be a prosodic phrase break following the Wh-word. In Tumbuka, this break follows from the general phrasing algorithm of the language, while in Chewa, I propose that the break can be best understood as following from the inherent prominence of Wh-words.
This paper sketches the morphosyntactic and prosodic properties of questions in Fipa, discussing three varieties: Milanzi, Nkansi and Kwa. The general word order and morphological patterns relevant to question structures are outlined and different types of wh-question constructions are described and tentatively linked to the prosodic features of Fipa questions.
The purpose of this paper is to show how WH questions interact with the complex tonal phenomena which we summarized and illustrated in Hyman & Katamba (2010). As will be seen, WH questions have interesting syntactic and tonal properties of their own, including a WH-specific intonation. The paper is structured as follows: After an introduction in §1, we successively discuss non-subject WH questions (§2), subject WH questions (§3), and clefted WH questions (§4). We then briefly present a tense which is specifically limited to WH questions (§5), and conclude with a brief summary in §6.
This questionnaire is intended as an aid to eliciting different question types, including yes/no questions, alternative questions, and wh-questions on a range of constituents. We have taken care to include examples that allow one to test for common Bantu phenomena, such as a subject/non-subject asymmetry in wh-questions and an obligatory immediately after the verb (IAV) position for questioning verb complements. The questionnaire is intended as a guide, only, as every language will have its own set of possibilities and complications. At the end of the questionnaire is a checklist. While we had Bantu languages in mind in devising the questionnaire, we hope it will also be useful to linguists with an interest question constructions in other languages.
Theatre constitutes a form of collective creativity. This idea is not as self-evident as one might expect. To some extent the collective Character of this art form had to be rediscovered over the course of the twentieth century, as theatre emancipated itself from the primacy of the literary text and thus from the primacy of the author. In fact, the collective character of this art form was fully brought into view again only with the debates about a post-dramatic theatre of the last few decades. In this essay I will tum back to the point in cultural history when literature started to dominate theatre and when the supremacy accorded the author began to annul theatre's collective character. This paradigmatic shift in the evolution of theatre occurred during the eighteenth century, and it is represented primarily by Johann Christoph Gottsched. In the following I will investigate Gottsched's efforts to reform the theatre of his age from a mediological point of view.
In this paper, I revisit the arguments against the use of fuzzy logic in linguistics (or more generally, against a truth-functional account of vagueness). In part, this is an exercise to explain to fuzzy logicians why linguists have shown little interest in their research paradigm. But, the paper contains more than this interdisciplinary service effort that I started out on: In fact, this seems an opportune time for revisiting the arguments against fuzzy logic in linguistics since three recent developments affect the argument. First, the formal apparatus of fuzzy logic has been made more general since the 1970s, specifically by Hajek [6], and this may make it possible to define operators in a way to make fuzzy logic more suitable for linguistic purposes. Secondly, recent research in philosophy has examined variations of fuzzy logic ([18, 19]). Since the goals of linguistic semantics seem sometimes closer to those of some branches of philosophy of language than they are to the goals of mathematical logic, fuzzy logic work in philosophy may mark the right time to reexamine fuzzy logic from a linguistic perspective as well. Finally, the reasoning used to exclude fuzzy logic in linguistics has been tied to the intuition that p and not p is a contradiction. However, this intuition seems dubious especially when p contains a vague predicate. For instance, one can easily think of circumstances where 'What I did was smart and not smart.' or 'Bea is both tall and not tall.' don’t sound like senseless contradictions. In fact, some recent experimental work that I describe below has shown that contradictions of classical logic aren’t always felt to be contradictory by speakers. So, it is important to see to what extent the argument against fuzzy logic depends on a specific stance on the semantics of contradictions. In sum then, there are three good reasons to take another look at fuzzy logic for linguistic purposes.
'Perhaps the sodomites should be written out of Dante's "Inferno"', Jarman wrote in his journal on 1 August 1990: 'I'll offer myself as the ghostwriter.' What does he mean by 'ghostwriter' here? How queer is this odd speech-act? What is he offering to do to the homophobic landscape of the "Inferno", that forbiddingly sealed textual prison, with his Hollywood pitchman's casual bid to 'write out' the sodomites as if they were a slight embarrassment to the divine justice system? Is he speaking in jest as a writer of gay satires and sacrilegious memoirs, or in deadly earnest as an activist who had renounced the middle-class pretensions and frivolities of the pre-AIDS gay world? [...] Jarman counters the trope of homosexual theft visually with the triumphant figure of Man with Snake. The Dantesque merging of snake and thief is replaced by an erotic dance in which the gilded youth raises his phallic partner above his head and seductively kisses it on the mouth. Whereas Dante would have us notice the grotesque parody of the Trinity played out in the seventh bolgia - with the unchanging Puccio as God the Father, the two-natured Agnello-Cianfa as Christ, and the fume-veiled Buoso receiving his forked tongue from the serpent Francesco in a demonic replay of the gift of tongues from the Spirit - Jarman clears away all overdetermined theological meanings to revel in the purely aesthetic impact of the phallic dancer. All the ghosts from Dante's snakepit are conjured away in the film and replaced with the solid presence of a single gorgeously spotlit male body. Ghostwriting Dante, for Jarman, meant more than a mere appropriation of homoerotic scenes from the "Inferno" into his screenplay. It meant a complete reimagining of their aesthetic significance within the filmscape of his Dantean transformations.
The 1935 Fox Films "Dante's Inferno" (directed by Harry Lachman) traces the rise and fall of an entrepreneur. Its protagonist, Jim Carter (played by Spencer Tracy), begins the story as a stoker on a cruise liner. The narrative opens with a burst of flames from the ship's boiler, and the ensuing scene goes on to show the protagonist competing at shovelling coal for a bet in the sweltering engine-room. Interspersed are shots of the superstructure directly above with a number of elegant and vapid passengers following the game below. This initial sequence thus concisely conveys the main features of the film's social agenda through imagery that anticipates that of two of its later 'infernal' sequences. [...] Spectacular admonition and concern about the ruthless pursuit of wealth are the main features which link this "Inferno" of the thirties to the one that had appeared some six hundred years earlier. Wealth and avarice were, of course, demonstrably serious concerns for Dante: as Peter Armour, for example, has shown, there is a recurrent and pervasive concern with money, its meaning, and its misuse throughout the "Commedia". So it is not surprising that the "Inferno" should also have been appropriated by social critics some hundred years before the 1935 Hollywood fable. [...] Some of the narrative and visual patterns in "Dante's Inferno" imply an uneasy underlying vision of the movie industry and its practices. Other productions, publicity, and journalism of the time reinforce suggestions of such a metafictional approach to movies, morality, and the market in the 1935 "Dante's Inferno".
Between 1816 and 1821, the philologist François Raynouard (1761–1836) published a "Choix des poésies originales des troubadours". His connections with Madame de Staël's cultural circle at Coppet determined the construction of the myth of courtly love as a forerunner of Romantic love. [...] Acording to this cultural tradition, Dante is an intermediate (although pre-eminent) step in the history of Western desire, a process begun in medieval Provence and revitalized by European Romanticism. When Lacan approaches Dante, it is therefore one Dante - this Dante - that he is approaching. The present essay, in which Fabio Camilletti analyses three tightly interwoven texts, explores some of the reverberations of this encounter. In 1958, Lacan published in "Critique" an article entitled 'La jeunesse d'André Gide, ou la lettre et le désir'. This text, later included in Lacan's "Écrits", was meant to be a review of a biography of the young Gide published in 1956 by Jean Delay, entitled "La jeunesse d'André Gide". In comparing Gide's life with his works of youth, Delay notably focused on Gide's novel of 1891, "Les Cahiers d'André Walter", the third text on which Camilletti focuses his inquiry. These three texts evoke in various ways the relationship between Dante and Beatrice, using it as a cultural allusion through which specific problems of sexuality (or, better, of the absence of sexuality) are conveyed. This essay aims therefore to be a study in the rhapsodic and subterranean presence of Dante and the "Vita Nova" between the end of the nineteenth and the twentieth centuries, as well as in the relationship between literature and psychoanalysis through the quartet Dante-Gide-Delay-Lacan.