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Background: Point of care devices for performing targeted coagulation substitution in bleeding patients have become increasingly important in recent years. New on the market is the Quantra® from HemoSonics (LC, Charlottesville, VA, US). It uses sonorheometry, a sonic estimation of elasticity via resonance (SEER), a novel ultrasound-based technology that measures viscoelastic properties of whole blood. Several studies have already shown the comparability with devices already established on the market such as the ROTEM® (TEM International GmbH, Munich, Germany).
Objective: In contrast to existing studies, the planned study will be the first prospective interventional study using the new Quantra® system in a cardiac surgical patient cohort. The aim is to investigate the non-inferiority between an already existing coagulation algorithm, based on ROTEM®/Multiplate®, and a new algorithm based on the Quantra®, for the treatment of coagulopathic cardiac surgical patients.
Methods: The study is divided into two phases. In an initial observation phase, whole blood samples of 20 patients will be analyzed using both ROTEM®/Multiplate® and Quantra® obtained at three defined points of time (prior to surgery, after completion of cardiopulmonary bypass, on arrival in the intensive care unit). The obtained threshold values will be used to create an algorithm for hemotherapy. In a second intervention phase, the new algorithm will be tested against an algorithm used routineously for years at our department for non-inferiority.
Results: The main objective of the examination is the cumulative loss of blood within 24 hours after surgery. Statistical calculations based on literature and in-house data suggest that the new algorithm is not inferior if the difference in cumulative blood loss is < 150ml/24 h.
Conclusions: Because of the comparability of the Quantra® sonorheometry system with ROTEM® rotational thromboelastometric measurement methods, the existing hemotherapy treatment algorithm can be adapted to the Quantra device with a proof of non-inferiority. Clinical Trial: International Registered Report Identifier (IRRID): clinicaltrials.gov: NCT03902275
We present novel measurements of five short-lived brominated source gases (CH2Br2, CHBr3, CH2ClBr, CHCl2Br and CHClBr2) obtained using a gas chromatograph-mass spectrometer system on board the High Altitude and Long Range Research Aircraft (HALO). The instrument is extremely sensitive due to the use of chemical ionisation, allowing detection limits in the lower parts per quadrillion (10-15) range. Data from three campaigns using the HALO aircraft are presented, where the Upper Troposphere/Lower Stratosphere (UTLS) of the Northern Hemisphere mid to high latitudes were sampled during winter and during late summer to early fall. We show that an observed decrease with altitude in the stratosphere is consistent with the relative lifetimes of the different compounds. Distributions of the five source gases and total organic bromine just below the tropopause shows an increase in mixing ratio with latitude, in particular during polar winter. This increase in mixing ratio is explained by increasing lifetimes at higher latitudes during winter. As the mixing ratio at the extratropical tropopause are generally higher than those derived for the tropical tropopause, extratropical troposphere-to-stratosphere transport will result in elevated levels of organic bromine in comparison to air transported over the tropical tropopause. The observations are compared to model estimates using different emission scenarios. A scenario which has emissions most strongly concentrated to low latitudes cannot reproduce the observed latitudinal distributions and will tend to overestimate bromine input through the tropical tropopause from CH2Br2 and CHBr3. Consequently, the scenario also overestimates the amount of brominated organic gases in the stratosphere. The two scenarios with the highest overall emissions of CH2Br2 tend to overestimate mixing ratios at the tropical tropopause but are in much better agreement with extratropical tropopause values, showing that not only total emissions but also latitudinal distributions in the emissions are of importance. While an increase in tropopause values with latitude is reproduced with all emission scenarios during winter, the simulated extratropical tropopause values are on average lower than the observations during late summer to fall. We show that a good knowledge of the latitudinal distribution of tropopause mixing ratios and of the fractional contributions of tropical and extratropical air is needed to derive stratospheric inorganic bromine in the lowermost stratosphere from observations. Depending on the underlying emission scenario, differences of a factor 2 in reactive bromine derived from observations and model outputs are found for the lowermost stratosphere, based on source gas injection. We conclude that a good representation of the contributions of different source regions is required in models for a robust assessment of the role of short-lived halogen source gases on ozone depletion in the UTLS.
Simple Summary: Pseudoprogression detection in glioblastoma patients remains a challenging task. Although pseudoprogression has only a moderate prevalence of 10–30% following first-line treatment of glioblastoma patients, it bears critical implications for affected patients. Non-invasive techniques, such as amino acid PET imaging using the tracer O-(2-[18F]-fluoroethyl)-L-tyrosine (FET), expose features that have been shown to provide useful information to distinguish tumor progression from pseudoprogression. The usefulness of FET-PET in IDH-wildtype glioblastoma exclusively, however, has not been investigated so far. Recently, machine learning (ML) algorithms have been shown to offer great potential particularly when multiparametric data is available. In this preliminary study, a Linear Discriminant Analysis-based ML algorithm was deployed in a cohort of newly diagnosed IDH-wildtype glioblastoma patients (n = 44) and demonstrated a significantly better diagnostic performance than conventional ROC analysis. This preliminary study is the first to assess the performance of ML in FET-PET for diagnosing pseudoprogression exclusively in IDH-wildtype glioblastoma and demonstrates its potential.
Abstract: Pseudoprogression (PSP) detection in glioblastoma remains challenging and has important clinical implications. We investigated the potential of machine learning (ML) in improving the performance of PET using O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) for differentiation of tumor progression from PSP in IDH-wildtype glioblastoma. We retrospectively evaluated the PET data of patients with newly diagnosed IDH-wildtype glioblastoma following chemoradiation. Contrast-enhanced MRI suspected PSP/TP and all patients underwent subsequently an additional dynamic FET-PET scan. The modified Response Assessment in Neuro-Oncology (RANO) criteria served to diagnose PSP. We trained a Linear Discriminant Analysis (LDA)-based classifier using FET-PET derived features on a hold-out validation set. The results of the ML model were compared with a conventional FET-PET analysis using the receiver-operating-characteristic (ROC) curve. Of the 44 patients included in this preliminary study, 14 patients were diagnosed with PSP. The mean (TBRmean) and maximum tumor-to-brain ratios (TBRmax) were significantly higher in the TP group as compared to the PSP group (p = 0.014 and p = 0.033, respectively). The area under the ROC curve (AUC) for TBRmax and TBRmean was 0.68 and 0.74, respectively. Using the LDA-based algorithm, the AUC (0.93) was significantly higher than the AUC for TBRmax. This preliminary study shows that in IDH-wildtype glioblastoma, ML-based PSP detection leads to better diagnostic performance.
Accurate multidimensional localization of isolated fluorescent emitters is a time consuming process in single-molecule based super-resolution microscopy. We demonstrate a functional method for real-time reconstruction with automatic feedback control, without compromising the localization accuracy. Compatible with high frame rates of EM-CCD cameras, it relies on a wavelet segmentation algorithm, together with a mix of CPU/GPU implementation. A combination with Gaussian fitting allows direct access to 3D localization. Automatic feedback control ensures optimal molecule density throughout the acquisition process. With this method, we significantly improve the efficiency and feasibility of localization-based super-resolution microscopy.
Feedforward inhibition and synaptic scaling are important adaptive processes that control the total input a neuron can receive from its afferents. While often studied in isolation, the two have been reported to co-occur in various brain regions. The functional implications of their interactions remain unclear, however. Based on a probabilistic modeling approach, we show here that fast feedforward inhibition and synaptic scaling interact synergistically during unsupervised learning. In technical terms, we model the input to a neural circuit using a normalized mixture model with Poisson noise. We demonstrate analytically and numerically that, in the presence of lateral inhibition introducing competition between different neurons, Hebbian plasticity and synaptic scaling approximate the optimal maximum likelihood solutions for this model. Our results suggest that, beyond its conventional use as a mechanism to remove undesired pattern variations, input normalization can make typical neural interaction and learning rules optimal on the stimulus subspace defined through feedforward inhibition. Furthermore, learning within this subspace is more efficient in practice, as it helps avoid locally optimal solutions. Our results suggest a close connection between feedforward inhibition and synaptic scaling which may have important functional implications for general cortical processing.
Background: Patient Blood Management (PBM) is a systematic quality improving clinical model to reduce anemia and avoid transfusions in all kinds of clinical settings. Here, we investigated the potential of PBM in oncologic surgery and hypothesized that PBM improves 2-year overall survival (OS).
Methods: Retrospective analysis of patients 2 years before and after PBM implementation. The primary endpoint was OS at 2 years after surgery. We identified a sample size of 824 to detect a 10% improvement in survival in the PBM group.
Results: The analysis comprised of 836 patients that underwent oncologic surgery, 389 before and 447 after PBM, was implemented. Patients in the PBM+ presented significantly more frequent with normal hemoglobin values before surgery than PBM− (56.6 vs. 35.7%; p < 0.001). The number of transfusions was significantly reduced from 5.5 ± 11.1 to 3.0 ± 6.9 units/patient (p < 0.001); moreover, the percentage of patients being transfused during the clinic stay was significantly reduced from 62.4 to 40.9% (p < 0.001). Two-year OS was significantly better in the PBM+ and increased from 67.0 to 80.1% (p = 0.001). A normal hemoglobin value (> 12 g/dl in female and > 13 g/dl in male) before surgery (HR 0.43, 95% CI 0.29–0.65, p < 0.001) was the only independent predictive factor positively affecting survival.
Conclusions: PBM is a quality improvement tool that is associated with better mid-term surgical oncologic outcome. The root cause for improvement is the increase of patients entering surgery with normal hemoglobin values.
Ovaj se rad bavi položajem zanaglasnica u kontekstu njegove obrade u nastavi hrvatskoga jezika u srednjim školama. S obzirom na to da pisani korpus pokazuje velika odstupanja od klasičnoga tumačenja Wackernagelova pravila (Peti-Stantić 2007), htjele smo ovu pojavu istražiti u kontekstu odnosa nastavnika hrvatskoga jezika prema poučavanju pravila o položaju zanaglasnica. Dosadašnji radovi u ovome području pokazuju različite težnje. Dok većina suvremenih gramatika (Babić i dr. 2007, Barić i dr. 2005, Težak i Babić 1994) staje u prilog prozodijskome tumačenju Wackernagelova pravila, prema kojemu se zanaglasnica uvrštava iza prve naglašene riječi u rečenici, neki suvremeni jezikoslovci (Peti-Stantić 2002, 2002a, 2006, 2007) zagovaraju sintaktičko tumačenje ovoga pravila u hrvatskome jeziku, prema kojemu se zanaglasnice smještaju iza prve naglašene sintaktičke jedinice. Ovi drugi svoje tvrdnje podupiru neskladom između propisanih pravila i stvarne uporabe, tj. korpusa, a naše se istraživanje bavi sličnim problemom – odnosom između načelnih i praktičnih elemenata poučavanja ovoga pravila. Ispitivanje predodžbe nastavnika o pravilu o položaju zanaglasnica u hrvatskome jeziku te prakse poučavanja toga pravila otkrilo je da nastavnici daju prednost prozodijskom tumačenju Wackernagelova pravila, no nisu skloni ispravljanju učenika koji ga drugačije primjenjuju.
Background: In March 2020, the COVID-19 outbreak led to the declaration of a pandemic. The accompanying restrictions on public life caused a change in the training routines of athletes worldwide. The present study aimed to investigate the effects of a 13-week supervised home training program on physical performance, sleep quality, and health-related quality of life in professional youth soccer players during the first COVID-19 lockdown in Germany.
Methods: Eight professional soccer players (age range 16–19; height: 1.81 ± 0.07 m; body weight: 72.05 ± 6.96 kg) from a Bundesliga team in Germany participated in this study. During the lockdown, they trained 5–6 days per week with home-based training plans and were monitored via tracking apps and video training. To determine the effects of home training, measurements were taken before (March 2020) and after (June 2020) the home training period. Bioelectrical impedance analysis was used to determine body composition, and an isokinetic strength test and a treadmill step test, including lactate measurements, were used to measure physical performance. Two questionnaires were responded to in order to assess health-related quality of life [Short-Form 36 Health Survey (SF-36)] and sleep quality (Pittsburgh Sleep Quality Index).
Results: When comparing measurements before and after the home training period, we observed significant increases in the following variables: body weight (72.05 ± 6.96 kg vs. 73.50 ± 6.68 kg, p = 0.034), fat mass (11.99 ± 3.13 % vs. 13.98 ± 3.92 %, p = 0.030), body mass index (22.04 ± 0.85 kg/m2 vs. 22.49 ± 0.92 kg/m2, p = 0.049), and mental health component summary score (MCS) of the questionnaire SF-36 (53.95 ± 3.47 vs. 58.33 ± 4.50, p = 0.044). Scores on the general health (77.88 ± 14.56 vs. 89.75 ± 13.76, p = 0.025) and mental health (81.50 ± 9.30 vs. 90.00 ± 11.71, p = 0.018) subscales of the SF-36 also increased significantly.
Conclusion: The COVID-19 lockdown led to an increase in body composition parameters and showed an improvement in the MCS and scores on the general and mental health subscales of the SF-36. Physical performance and sleep quality could be maintained during the home training period. These observations may help trainers for future training planning during longer interruptions in soccer training.
Introduction: Our aim was to highlight the characteristics of pediatric Meckel's diverticulum with a special focus on its complications.
Methods: We report a group of seven patients with Meckel's diverticulum and its resection from the Department of Pediatric Surgery between 2012 and 2017. We reviewed all patient records, clinical presentation, and intraoperative findings. The diagnosis was confirmed by surgery and pathology. For a systematic literature review, we used PubMed, Medline and Google Scholar search engines to locate articles containing terms such as Meckel's diverticulum, children, pediatric, complications and symptomatic. We included article reporting on case series in English and German on pediatric patients only.
Results: All included patients (n = 7) were symptomatic. Some patients showed isolated symptoms, and others presented with a combination of symptoms that consisted of abdominal pain, bloody stool or vomiting. The median age of our seven cases was 3.5 years, including 4 male and 3 female patients. Intestinal obstruction was the most common complication; it was seen in 5 out of 7 patients (intussusception in 4 cases, volvulus in 1 case). Ectopic gastric tissue was identified in 3 cases, and inclusion of pancreatic tissue was observed in 1 case. The literature review identified 8 articles for a total of 641 patients aged between 1 day and 17 years and a male:female ratio of 2.6:1. From this group, 528 patients showed clinical symptoms related to Meckel's diverticulum. The most common symptom was abdominal pain and bloody stool. The most common surgical finding in symptomatic patients was intestinal obstruction (41%), followed by intestinal hemorrhage (34%). Complications such as perforation (10%) and diverticulitis (13%) were less frequently reported. Heterotopic tissue was confirmed on histopathology in 53% of all patients enclosing gastric, pancreatic, and both gastric and pancreatic mucosae. In one case, large intestine tissue could be found. Overall, one death was reported.
Conclusion: The presented case series and literature review found similar clinical presentations and complications of Meckel's diverticulum in children. Intestinal obstruction and bleeding are more frequent than inflammation in pediatric Meckel's diverticulum. Bowel obstruction is the leading cause for complicated Meckel's diverticulum in patients younger than 12 years.
We report a case of a 2-day-old neonate with bilious vomiting and abdominal distension. A small bowel obstruction with ileal perforation due to a misplaced clamping of the umbilical cord was apparent before laparotomy. This complication was a sequala after clamping the cord too close to the abdominal wall in a case where there was a hernia into the cord with intestinal content. A herniation of abdominal contents due to an omphalocele minor or a hernia must be taken into consideration during the inspection of the umbilical cord before clamping.
Introduction: Endovascular aortic repair, if technically feasible, is the treatment of choice for patients with a contained ruptured aortic aneurysm who are unfit for open surgery. Case presentation: We report the case of an 80-year-old Caucasian man who presented with an unusually configured, symptomatic infrarenal aortic aneurysm. His aneurysm showed an erosion of the fourth lumbar vertebra and a severely arteriosclerotic pelvic axis. A high thigh amputation of his right leg had been performed 15 months previously. On his right side, occlusion of his external iliac artery, common femoral artery, and deep femoral artery had occurred. His aneurysm was treated by a left-sided aortomonoiliac stent graft without femorofemoral revascularization, resulting in occlusions of both internal iliac arteries. No ischemic symptoms appeared, although perfusion of his right side was maintained only over epigastric collaterals. Conclusions: The placement of aortomonoiliac stent grafts for endovascular treatment of infrarenal aortic aneurysms without contralateral revascularization is a feasible treatment option in isolated cases. In this report, access problems and revascularization options in endovascular aneurysm repair are discussed.
STADT FÜR ALLE! steht in großen rosa Buchstaben auf der Fassade des verlassenen Amerika Instituts. Das mit Graffiti überzogene Gebäude ist den meisten Bewohner:innen des Frankfurter Westends eher ein Dorn im Auge. Was aber vielen Frankfurter:innen nicht mehr bekannt sein dürfte, ist die enorme politische Aufladung, die der Bau als öffentlicher Schauplatz in sich birgt. Ein historischer Rückblick.
Artificial splitting of a non‐ribosomal peptide synthetase by inserting natural docking domains
(2020)
The interaction in multisubunit non‐ribosomal peptide synthetases (NRPSs) is mediated by docking domains that ensure the correct subunit‐to‐subunit interaction. We introduced natural docking domains into the three‐module xefoampeptide synthetase (XfpS) to create two to three artificial NRPS XfpS subunits. The enzymatic performance of the split biosynthesis was measured by absolute quantification of the products by HPLC‐ESI‐MS. The connecting role of the docking domains was probed by deleting integral parts of them. The peptide production data was compared to soluble protein amounts of the NRPS using SDS‐PAGE. Reduced peptide synthesis was not a result of reduced soluble NRPS concentration but a consequence of the deletion of vital docking domain parts. Splitting the xefoampeptide biosynthesis polypeptide by introducing docking domains was feasible and resulted in higher amounts of product in one of the two tested split‐module cases compared to the full‐length wild‐type enzyme.
Weiden (Salix spp., Salicaceae) gehören zu den typischen Gehölzarten der Flussauen in Mitteleuropa. Viele Arten dieser Gattung haben ähnliche Eigenschaften (life history traits) und Strategien bei der Besiedelung frisch entstandener Rohböden. In Auenhabitaten kommen deshalb häufig mehrere Weidenarten gemeinsam vor und treten deshalb miteinander in Konkurrenz. In der vorliegenden Arbeit wurde untersucht, ob interspezifische phänologische Unterschiede in der Zeit der Samenausbreitung in Verbindung mit wechselnden Pegelständen des Flusses dazu führen, dass sich koexistierende Weidenarten räumlich differenziert ansiedeln und so die interspezifische Konkurrenz zwischen den Weiden reduziert wird. Auf frisch sedimentierten Auenböden an der Rodach und am Oberlauf des Mains (Oberfranken, Nordostbayern) wurde der Einfluss der Zeit des Samenfluges und der Schwankung der Pegelstände auf die räumliche Verteilung der Keimlinge von Salix fragilis s.l., S. purpurea, S. triandra und S. viminalis auf zwei Aufnahmeflächen untersucht. Ergänzt wurden diese Freilandstudien durch Untersuchungen zur Keimfähigkeit von Samen dieser Arten unter verschiedenen Bedingungen im Labor. Die Keimfähigkeit der Samen betrug unmittelbar nach ihrer Reife mindestens 80-100%. Bei trockener Lagerung (20 °C) erlosch die Keimfähigkeit von S. fragilis und S. triandra nach 4 Wochen, bei S. purpurea und S. viminalis nach spätestens 6 Wochen. Die Samen aller Arten können auch im Wasser keimen.
Anhand des Zeitraumes der Samenausbreitung lassen sich die im Freiland untersuchten Weiden in eine früh (S. purpurea und S. viminalis) und in eine spät fruktifizierende Gruppe (S. fragilis s.l. und S. triandra) unterscheiden. Die Keimlinge aller Arten traten jeweils nur in einem schmalen Saum entlang des Ufers auf. Die Pegel von Main und Rodach an den Untersuchungsflächen waren während des Samenfluges der früh fruktifizierenden Gruppe höher als während des Samenfluges der spät fruktifizierenden Gruppe. Keimlinge beider Gruppen etablierten sich deshalb in unterschiedlichen Reliefbereichen und in unterschiedlicher Entfernung zum Ufer: bezogen auf einen sommerlichen Tiefstand des Wassers waren die Keimlinge der früh fruktifizierenden Arten (S. purpurea und S. viminalis) höher auf der Kiesbank und weiter vom Ufer entfernt als die der spät fruktifizierenden Arten (S. fragilis s.l. und S. triandra). Phänologische Unterschiede ermöglichen somit in Kombination mit sinkenden Wasserständen eine räumlich differenzierte Verteilung von Keimlingen verschiedener Weidenarten auf engstem Raum. Dies trägt zur Verringerung interspezifischer Konkurrenz und zu einer hohen Diversität von Salix-Arten in alluvialen Habitaten bei.
The article presents two surgical texts written in Strasbourg around 1500. The author of the first text is Hieronymus Brunschwig, and the second is by Hans Gersdorff. Although Gersdorff's book is more like a teaching text, a set of normative instructions in the manner of (legally binding) municipal records, it was published under the name 'Feldbuch'. The publisher may have chosen this designation under the influence of texts named Feldbücher, originating in the Moravian-Silesian region, which were originally intended as manuals for barber surgeons working on battlefields
Asplenium adiantum-nigrum (Aspleniaceae, Pteridophyta) breitet sich seit ca. 20 Jahren von seinem Arealrand im Rheinisch-Westfälischen Mittelgebirge ins Tiefland hinein aus. Die bislang in Nordrhein-Westfalen collin-montan verbreitete Farnart besaß dort bis zum Ende der 1980er Jahre eine stabile Verbreitungsgrenze mit Vorkommen an Felsstandorten des Ruhrtals (südliches Ruhrgebiet). Ausbreitungsgeschichte, Populationsentwicklung, Gesellschaftsanschluss sowie die neuen Wuchsorte werden dargestellt. Insgesamt konnten seit 1990 25 Neufunde, 16 davon im planaren Raum des Niederrheinischen Tieflandes und der Westfälischen Bucht, mit einer Gesamtpopulation von über 580 Individuen verzeichnet werden. Die Ursachen der Arealerweiterung werden anhand von vier Hypothesen und unter Berücksichtigung von Untersuchungsergebnissen aus West- und Nordwesteuropa diskutiert. Eine derzeit häufig diskutierte mögliche Ursache der Arealerweiterung ist die seit Jahren erkennbare Klimaerwärmung, bei der insbesondere die milderen Winter und wärmeren Sommer u.a. zu einer Veränderung der Luftfeuchtigkeit führen. Diese scheidet jedoch im Falle von Asplenium adiatum-nigrum zumindest als monokausale Erklärung aus. Die veränderten klimatischen Faktoren überlagern sich zeitgleich mit einer einhergehenden Luftverbesserung (insbesondere Verringerung der SO2-Immissionen) und höheren Stickstoffimmissionen, welche letztlich die Wuchsbedingungen des Farntaxons insgesamt positiv beeinflussen können. Ein belegbarer Zusammenhang zwischen Ausbreitung des Taxons und den veränderten Klima- sowie Umweltbedingungen ist derzeit allerdings nicht gegeben.
Im Rahmen stadtfloristischer Untersuchungen des Ruhrgebietes wurden in Brunnen- und Kellerlichtschächten Vorkommen von Pteris cretica var. albolineata (Pteridaceae) und Adiantum raddianum (Adiantaceae) nachgewiesen, beide taxonomisch im weiteren Sinne zu verstehen. Die Wuchsorte, Populationsgrößen und Begleitvegetation werden beschrieben, Status und Ausbreitungstendenzen der Taxa diskutiert.
RNA-binding proteins (RBPs) control every RNA metabolic process by multiple protein-RNA and protein-protein interactions. Their roles have largely been analyzed by crude mutations, which abrogate multiple functions at once and likely impact the structural integrity of the large ribonucleoprotein particles (RNPs) these proteins function in. Using UV-induced RNA-protein crosslinking of entire cells, protein complex purification and mass spectrometric analysis, we identified >100 in vivo RNA crosslinks in 16 nuclear mRNP components in Saccharomyces cerevisiae. For functional analysis, we chose Npl3, which displayed crosslinks in its two RNA recognition motifs (RRMs) and in the connecting flexible linker region. Both RRM domains and the linker uniquely contribute to RNA recognition as revealed by NMR and structural analyses. Interestingly, mutations in these regions cause different phenotypes, indicating distinct functions of the different RNA-binding domains. Notably, an npl3-Linker mutation strongly impairs recruitment of several mRNP components to chromatin and incorporation of other mRNP components into nuclear mRNPs, establishing a so far unknown function of Npl3 in nuclear mRNP assembly. Taken together, our integrative analysis uncovers a specific function of the RNA-binding activity of the nuclear mRNP component Npl3. This approach can be readily applied to RBPs in any RNA metabolic process.
Die Grenzen zwischen Wirklichkeit und Fantasie beim Film sind fließend - besonders für Kinder und Jugendliche. Während Kinder dem Gesehenen durch Mimik, Gestik, Anrede und direktes Eingreifen spontan und aktiv Ausdruck verleihen, vermindert sich diese Neigung zum aktiven Miterleben der filmischen Handlung im Laufe der Pubertät auf ein Minimum. Der Autor erläutert, in welchen wesentlichen Punkten und aus welchen Gründen sich die Filmwahrnehmung bei Kindern und Jugendlichen von der Wahrnehmung erwachsener Zuschauer unterscheidet. Vor allem in Hinsicht auf eine gesamtpersönliche Beteiligung an Inhalt und Ablauf des Filmes sind Alter und Geschlecht der Kinder, Persönlichkeitstypus, Bildungsschicht und Grad der Faszination durch einen bestimmten Film entscheidende Faktoren.
Wie können Unternehmen bei der Auswahl von Bewerbern zukünftig besser zwischen Quantität und Qualität abwägen? Welche Wege sollten Kandidaten bei der Suche nach ihrem Wunscharbeitgeber einschlagen? Fragen, mit denen sich die Frankfurter Wirtschaftsinformatiker beschäftigen. Das Internet hat in den letzten Jahren die Personalbeschaffung erobert: Viele große und mittlere Unternehmen suchen ihr neues Personal inzwischen überwiegend auf elektronischem Weg. So lassen sich nicht nur die Kosten für das Personalmarketing deutlich reduzieren, auch die Rekrutierungszeiten werden kürzer. Doch gleichzeitig sehen sich die Unternehmen einer wachsenden Flut von Bewerbern gegenüber: Stellensuchende nutzen – verstärkt durch den Druck des Arbeitsmarkts – zunehmend die Chance, ihre Bewerbung über das Internet schnell, kostengünstig und an mehrere Unternehmen gleichzeitig elektronisch zu versenden. Um schnell die relevantesten Bewerber für ausgeschriebene Stellen zu identifizieren, benötigen die Unternehmen entsprechende Tools. Das Team um Wolfgang König und Tobias Keim erforscht innovative Lösungen.
"ûf der wortheide" : Hugo Suolahti und Emil Öhmann - zwei Altmeister der finnischen Germanistik
(2010)
Mit Hilfe des wissenschaftsgeschichtlichen Epithetons "Finnische Schule" für die Germanistik und für deren Paradigmenwechsel in den letzten gut 100 Jahren stellt der Beitrag das Lebenswerk der zwei finnischen Altmeister der germanischen Philologie Hugo Suolahti (1874-1944; o. Prof. in Helsinki 1911-1941) und Emil Öhmann (1894-1984; o. Prof. in Turku 1925-1944 und in Helsinki 1944-1963) vor. Nachdem an die Wichtigkeit der Studienaufenthalte in renommierten deutschen Germanistikzentren (Heidelberg, Freiburg, Leipzig und Berlin) für beide Forscherkarrieren erinnert wird, werden die zentralen Themenbereiche in den Forschungsouvres der zwei Akademiker umrissen. Bei Suolahti sind es die Tier- und Vogelnamen, französisch-deutsche Lehnwortbeziehungen im Mittelalter sowie germanisch-finnische Lehnwortbeziehungen. Bei Öhmann zeichnet sich ein noch breiteres Spektrum an Forschungsschwerpunkten ab: romanisch-deutsche Lehnbeziehungen bis zum Ausgang des Mittelalters, germanisch-finnische bzw. deutsch-finnische Lehnlexik, weitere lexikologisch-lexikographische Wortgeschichten; historische Phonologie, Morphologie und Syntax: Textgeschichte und Textkritik; Fragen der allgemeinen Sprachwissenschaft. Abschließend wird die breite und lange germanistische Nachwirkung von Suolahti und Öhmann am Beispiel ihrer Schülerinnen und Schüler vorgestellt.
This article tries to outline possible research topics in the field of comparative 20th century legal history between Europe and Latin-America. It seeks to examine changes both in Labour and Property law as core areas where social conceptions began to influence »liberal« private law. Focussing on an example from Mexican law in the aftermath of the revolution which took place in the first decades of the 20th century, it is argued that new conceptions in both fields were discussed using similar conceptual patterns in Europe and LatinAmerica. In the reaction of the jurists from both continents to the challenges of the new century lies a possibility for fruitful comparison. Conducting research in such a framework can also produce comparative results on the interplay between constitutional law and private law – especially when the focus lies on Germany and Mexico, where new constitutions at the beginning of the new century did evoke reactions in the discourses about private law. With regard to methodology it has to be observed that such research has to go far beyond the traditional pattern of »reception« of legal concepts from Europe in Latin-America, and to highlight more complex ways of transition of legal forms between the two continents.
In Germany, the termination of employment contracts is a central and often intensely debated legal issue today. This is not surprising since employment termination entails substantial risks for the person affected and threatens the very foundation of his or her economic existence. This is why both politics and legal dogmatics place the individual engaged in dependent work at the centre of concern as a subject requiring protection. In Germany, labour law ("Arbeitsrecht") emerged as an independent field of law focusing on the persona of the dependent worker ("Arbeitnehmer") and its typified normative ascriptions. This process took place in the course of the 20th century, as the concept of the principal requirement that employees be protected against unforeseen or unjustified dismissal became increasingly established, giving rise to very intricate regulations. Social security is a guiding motif of this legislation which regards contract termination primarily as a risk. It is often not considered that this constellation is a very new one. Defined conceptions of the interests of the parties to labour contracts also existed before 1900, but social security was then not a central criterion. At that time, many people perceived the termination of their employment as an opportunity rather than primarily as a risk. Employers, on the other hand, aimed to keep people in their service for as long as possible. In the late 19th century, the enforcement of labour performance by legal means and normative instruments, which no longer plays any role today, was still an important issue. This provides occasion to investigate the freedom of working people from the perspective of the history of law, whereby this article focuses on the history of the German-speaking territories. ...
Cortical tracking of stimulus features (such as the envelope) is a crucial tractable neural mechanism, allowing us to investigate how we process continuous music. We here tested whether cortical and behavioural tracking of beat, typically related to rhythm processing, are modulated by pitch predictability. In two experiments (n=20, n=52), participants’ ability to tap along to the beat of musical sequences was measured for tonal (high pitch predictability) and atonal (low pitch predictability) music. In Experiment 1, we additionally measured participants’ EEG and analysed cortical tracking of the acoustic envelope and of pitch surprisal (using IDyOM). In both experiments, finger-tapping performance was better in the tonal than the atonal condition, indicating a positive effect of pitch predictability on behavioural rhythm processing. Neural data revealed that the acoustic envelope was tracked stronger while listening to atonal than tonal music, potentially reflecting listeners’ violated pitch expectations. Our findings show that cortical envelope tracking, beyond reflecting musical rhythm processing, is modulated by pitch predictability (as well as musical expertise and enjoyment). Stronger cortical surprisal tracking was linked to overall worse envelope tracking, and worse finger-tapping performance for atonal music. Specifically, the low pitch predictability in atonal music seems to draw attentional resources resulting in a reduced ability to follow the rhythm behaviourally. Overall, cortical envelope and surprisal tracking were differentially related to behaviour in tonal and atonal music, likely reflecting differential processing under conditions of high and low predictability. Taken together, our results show diverse effects of pitch predictability on musical rhythm processing.
SUMO : glue or solvent for phase-separated ribonucleoprotein complexes and molecular condensates?
(2021)
Spatial organization of cellular processes in membranous or membrane-less organelles (MLOs, alias molecular condensates) is a key concept for compartmentalizing biochemical pathways. Prime examples of MLOs are the nucleolus, PML nuclear bodies, nuclear splicing speckles or cytosolic stress granules. They all represent distinct sub- cellular structures typically enriched in intrinsically disordered proteins and/or RNA and are formed in a process driven by liquid-liquid phase separation. Several MLOs are critically involved in proteostasis and their formation, disassembly and composition are highly sensitive to proteotoxic insults. Changes in the dynamics of MLOs are a major driver of cell dysfunction and disease. There is growing evidence that post-translational modifications are critically involved in controlling the dynamics and composition of MLOs and recent evidence supports an important role of the ubiquitin-like SUMO system in regulating both the assembly and disassembly of these structures. Here we will review our current understanding of SUMO function in MLO dynamics under both normal and pathological conditions.
The dynamic and reversible post-translational modification of proteins and protein complexes with the ubiquitin-related SUMO modifier regulates a wide variety of nuclear functions, such as transcription, replication and DNA repair. SUMO can be attached as a monomer to its targets, but can also form polymeric SUMO chains. While monoSUMOylation is generally involved in the assembly of protein complexes, multi- or polySUMOylation may have very different consequences. The evolutionary conserved paradigmatic signaling process initiated by multi- or polySUMOylation is the SUMO-targeted Ubiquitin ligase (StUbL) pathway, where the presence of multiple SUMO moieties primes ubiquitylation by the mammalian E3 ubiquitin ligases RNF4 or RNF111, or the yeast Slx5/8 heterodimer. The mammalian SUMO chain-specific isopeptidases SENP6 or SENP7, or yeast Ulp2, counterbalance chain formation thereby limiting StUbL activity. Many facets of SUMO chain signaling are still incompletely understood, mainly because only a limited number of polySUMOylated substrates have been identified. Here we summarize recent work that revealed a highly interconnected network of candidate polySUMO modified proteins functioning in DNA damage response and chromatin organization. Based on these datasets and published work on distinct polySUMO-regulated processes we discuss overarching concepts in SUMO chain function. We propose an evolutionary conserved role of polySUMOylation in orchestrating chromatin dynamics and genome stability networks by balancing chromatin-residency of protein complexes. This concept will be exemplified in processes, such as centromere/kinetochore organization, sister chromatid cohesion, DNA repair and replication.
Terrestrial, freshwater and estuarine native vegetation of the Eden region was classified into 79 floristic assemblages and mapped at 1:100,000 scale. Assemblages were derived from multivariate analysis of 1604 quantitative vegetation samples. Mapping was carried out using a hybrid decision tree-expert system approach based on quantitative relationships between floristic assemblages and spatial variables (land cover pattern, substrate, climatic variables and terrain variables) and qualitative expert knowledge derived from field experience. The use of vegetation environment relationships and sampling of remnants allowed prediction of vegetation patterns prior to European clearing. The map was validated using three procedures: qualitative checking by experts; reliability mapping using sampling intensity; and accuracy quantification using independent sample data. The map units were described using comprehensive profiles of diagnostic species, structural features, habitat characteristics and sample distributions.
The 79 floristic assemblages include rainforests, mesic eucalypt forests, dry grassy eucalypt forests of the coastal rain shadow valleys, hinterland and tableland, dry shrubby eucalypt forests, grasslands, heathlands, scrubs and wetlands. Variation in climate and geological substrate influence vegetation patterns at regional scales, while variation in topography, local soil moisture and nutrient status and disturbance regimes influence vegetation patterns at local scales. Sixty-eight per cent of the region retained a cover of native vegetation in 1994. Processes threatening various portions of the remainder include further habitat loss from clearing, high-frequency disturbances and certain other disturbance regimes, overgrazing, habitat degradation due to nutrification, dumping and vandalism, and feral animal activity. Past depletion of habitat has been highly biased. Some grassy assemblages on fertile flat terrain are depleted by more than 90%, while some forests with shrubby understories in steep infertile terrain retain close to their original extent. The former assemblages are distributed principally as remnants on privately owned land, while the latter occur in remote areas of public land. Representation in conservation reserves is also biased against grassy assemblages in fertile flat terrain, as well as some other assemblages with restricted distributions. Opportunities for conservation of these assemblages are now very limited and rely on integrated planning, reservation and cooperative management with emphasis on private land.
An exhaustive review of available information revealed 1522 native vascular plant taxa with confirmed records in the Eden region. A further 136 taxa potentially occur in the region, but these remain to be confirmed. Families represented by large numbers of taxa in the indigenous flora include the Fabaceae, Poaceae, Asteraceae, Myrtaceae and Orchidaceae. Species frequencies were highly skewed with 74% of the flora represented in less than 1% of survey samples and only three taxa represented in more than 40% of samples. A large number of records (350 taxa) were evaluated and refuted, emphasizing the importance of critical validation when compiling biological inventory data from multiple sources. Errors are most likely to arise from nomenclatural synonymy and other duplications, misidentifications and erroneous locality information.
The confirmed vascular flora of the Eden region is relatively species-rich compared with other regions in tropical, temperate and semi-arid Australia, although these regions are less well-known botanically. However, the proportion of endemism (1%) is comparatively low, with 18 taxa unique to the region and a further 14 taxa with distributions extending just beyond the region. The Eden region includes 32 taxa listed as endangered or vulnerable in Australia and a further six taxa listed as endangered in New South Wales but not throughout Australia. Thirty-eight taxa were listed as rare in Australia and a further 39 were considered to be uncommon throughout their distribution. Four hundred and sixty-six taxa were considered to be uncommon within the Eden region. Two hundred and seventy-six taxa reached their distributional limits in the Eden region, about three quarters of these reaching their southern limits. Fifty taxa were represented in the region by disjunct populations.
Introduced taxa accounted for approximately 20% of the total regional vascular flora, although this proportion is likely to underestimate the introduced flora given the limitations of available data. The introduced flora is dominated by Poaceae, Asteraceae, Fabaceae and Caryophyllaceae. Very few introduced taxa were widespread in native vegetation. The most common introduced taxa were herbs with long-distance propagule dispersal mechanisms.
Das Treiben der Kunst-Avantgarden in den ersten Jahrzehnten des 20. Jahrhunderts war ein übernationales gesamteuropäisches Phänomen - nicht nur im Sinne wechselseitiger transnationaler Einflüsse und Kooperationen, sondern auch in Strukturanalogien zwischen den Programmen und Produktionen in verschiedenen Ländern. Eine Verwandtschaft zwischen deutschsprachigem Dada und den russischsprachigen 'kubofuturistischen' Gruppen Gileja und 41° wurde, ausgehend vor allem von der in beiden literarischen Avantgarden gepflegten Lautpoesie, immer wieder beschworen, doch begnügte man sich dabei entweder mit ganz allgemeinen Feststellungen oder beschränkte sich auf eng begrenzte Teilaspekte. Ziel dieses Aufsatzes ist es, interkulturelle Kongruenzen und kulturspezifische Kontraste hinsichtlich der beiden poetischen Formen Laut- und visuelle Dichtung in den beiden Kulturräumen darzustellen und dabei zu zeigen, dass man es mit verschiedenen, doch verwandten Ausprägungen avantgardistischen Handelns zu tun hat.
Mistrust and social hierarchies as blind spots of ICT4D projects : lessons from Togo and Rwanda
(2019)
Information and communication technologies for development (ICT4D) are seen to have great potential for boosting democratization processes all over the world by giving people access to information and thereby empowering them to demand more accountability and transparency of authorities. Based on ethnographic research in Togo and Rwanda on an SMS-based citizen monitoring and evaluation system, this article argues that focusing on access to information is too narrow a view. We show that it is crucial to take into account the respective socio-political backgrounds, such as levels of mistrust or existing social hierarchies. In this context, mobile phone usage has rather varied and ambiguous meanings here. These dynamics can pose a challenge to the successful implementation of ICT4D projects aimed at political empowerment. By addressing these often overlooked issues, we offer explanations for the gap between ICT4D assumptions and people’s lifeworlds in Togo and Rwanda.
Within the context of eHealth interventions, a shared understanding of what constitutes engagement in and with eHealth technologies is missing. A clearer understanding of engagement could provide a valuable starting point for guidelines relating to the design and development of eHealth technologies. Given the cross-disciplinary use of the term “engagement,” investigating how engagement (and its components) is conceptualized in different domains could lead to determining common components that are deemed important for eHealth technological design. As such, the aim of this paper was 3-fold: (a) to investigate in which domains engagement features, (b) to determine what constitutes engagement in these different domains, and (c) to determine whether there are any common components that seem to be important. A comprehensive systematic scoping review of the existing literature was conducted in order to identify the domains in which engagement is used, to extract the associated definitions of engagement, and to identify the dimensionality or components thereof. A search of five bibliographic databases yielded 1,231 unique records. All titles, abstracts, and full texts were screened based on specific inclusion and exclusion criteria. This led to 69 articles being included for further analyses. The results showed that engagement is used in seven functional domains, categorized as follows: student (n = 18), customer (n = 12), health (n = 11), society (n = 10), work (n = 9), digital (n = 8), and transdisciplinary (n = 1) domains. It seems that some domains are more mature regarding their conceptualization and theorizing on engagement than others. Further, engagement was found to be predominantly conceptualized as a multidimensional construct with three common components (behavior, cognition, and affective) shared between domains. Although engagement is prolifically used in different disciplines, it is evident that little shared consensus as to its conceptualization within and between domains exists. Despite this, engagement is foremost seen as a state of being engaged in/with something, which is part of, but should not be confused with, the process of engagement. Behavior, cognition, and affect are important components of engagement and should be specified for each new context.
Understanding plant-plant interactions is essential in planning and implementing effective grassland management strategies. Positive and negative interactions generally co-occur in plant communities and the net effect of these interactions may depend on the disturbance regime, including grazing. Shrubs can act as biotic refuges by physically protecting neighbouring plants from herbivores. As a result, we would expect that in pastures the diversity and flowering success of plants is higher in the close vicinity of shrubs compared to the open vegetation. Nevertheless, we can also assume a competitive trade-off cost for plants that grow together with shrubs. In this study, we assessed the small-scale effects of dwarf shrubs (30–40 cm in diameter) on species density and flowering success. Specifically, we considered three types of microsites: (i) shrub interior, (ii) edge of shrub, and (iii) open pasture (more than 2 meters away from the shrub). We surveyed these three types of microsites using 10 × 10 cm sized plots both in grazed and ungrazed meadow steppe, in central Hungary. The highest species density was found at the edge of shrubs, both in grazed and ungrazed vegetation. Meanwhile, species density did not differ significantly between shrub interiors and the open pasture. However, in grazed vegetation, species flowering success was significantly higher in shrub interiors and edges than in the open pasture; no significant trend was observed for this measure in ungrazed vegetation. In contrast to previous studies, we did not detect a competitive effect of small-sized shrubs on plants in ungrazed vegetation. Our results indicate that small-sized shrubs protect other plants from herbivores and that the edge effect plays an important role for the maintenance of small-scale species diversity in pastures. Overall, our results underline the beneficial effect of biotic refuges in pastures and we suggest that retaining a sparse population of small-sized native shrubs is advantageous from a conservation point of view.
A twentieth century-long coupled atmosphere-ocean regional climate simulation with COSMO-CLM (Consortium for Small-Scale Modeling, Climate Limited-area Model) and NEMO (Nucleus for European Modelling of the Ocean) is studied here to evaluate the added value of coupled marginal seas over continental regions. The interactive coupling of the marginal seas, namely the Mediterranean, the North and the Baltic Seas, to the atmosphere in the European region gives a comprehensive modelling system. It is expected to be able to describe the climatological features of this geographically complex area even more precisely than an atmosphere-only climate model. The investigated variables are precipitation and 2 m temperature. Sensitivity studies are used to assess the impact of SST (sea surface temperature) changes over land areas. The different SST values affect the continental precipitation more than the 2 m temperature. The simulated variables are compared to the CRU (Climatic Research Unit) observational data, and also to the HOAPS/GPCC (Hamburg Ocean Atmosphere Parameters and Fluxes from Satellite Data, Global Precipitation Climatology Centre) data. In the coupled simulation, added skill is found primarily during winter over the eastern part of Europe. Our analysis shows that, over this region, the coupled system is dryer than the uncoupled system, both in terms of precipitation and soil moisture, which means a decrease in the bias of the system. Thus, the coupling improves the simulation of precipitation over the eastern part of Europe, due to cooler SST values and in consequence, drier soil.
Ann Cotten gilt dem Feuilleton als das aktuelle "Wunderkind der deutschen Literatur" und als die "klügste und schwierigste Dichterin in deutscher Sprache". [...] Ann Cotten nervt. [...] Doch was hat es mit dem Nerven auf sich? Ist das, was hier als Pose an- und vermeintlich vorgeführt wird, nicht etwas ganz anderes? Bereits diese ersten Hinweise zeigen, dass Cottens Spiel mit den Stillagen zwischen Virtuosität und Kalauer aufgeht: Es entlarvt die Kritik - sowohl in ihrem positiven als auch in ihrem negativen Urteil als Mansplaining, das mit Formeln wie 'Wunderkind', 'talentierte Autorin', Dekonstruktion etc. genau das einhegt, was mit dieser Literatur in Frage steht. Das Nerven, so manieriert es auch daherkommen mag, stellt eine intensiv reflektierte poetologische Dimension von Cottens Literaturauffassung und ihres Schreibens dar - ja man könnte von einer Poetik des Nervens sprechen. [...] Wenn Cotten, wie zu sehen sein wird, die Kategorie des Existenziellen wieder einführt, die vom (Post)Strukturalismus in Abhebung unter anderen von Sartre verabschiedet wurde, dann liebäugelt sie auch mit Autoren, die von ganz anderer Warte aus nerven. Zu ihnen zählt auch der in der Poetikvorlesung mehrfach genannte Peter Handke. Peter Handke nervt Ann Cotten, aber sie liest ihn auch und kann etwas mit ihm anfangen - inwiefern, wird zu sehen sein. Mit Handke steht ein weiteres ehemaliges 'Wunderkind' des Literaturbetriebs zur Debatte, bei dem jedoch seit ein paar Jahrzehnten eine Abwendung von den avantgardistisch-sprachkritischen Anfängen und eine Hinwendung zu einer mystischen Weltanschauung kritisch diagnostiziert wird. Die Empörung bei der Vergabe des Literaturnobelpreises an Handke im Herbst 2019 betraf vor allem seine proserbische Haltung sowie sein 'Frauenbild' und steigerte sich auch bis zum 'Durchdrehen'. Ist man bei Cotten über die dekonstruktivistische Pose genervt, so enerviert man sich bei Handke poetologisch gesehen darüber, dass er deren Einsichten zumindest in seinen jüngeren Werken trotzig negiere. [...] Seit der Tetralogie rund um die "Langsame Heimkehr" (1979) zeichnet sich bei Handke ein neuer Weltzugang und damit verbunden eine epische Erzählweise ab, denen Peter Hamm, knapp vier Monate nach dem Massaker von Srebrenica, in seiner Laudatio bei der Verleihung des Schillerpreises an Handke Folgendes attestiert: "Peter Handke hat das Schwierigste und Höchste gewagt, was ein Schriftsteller nach Kafka überhaupt wagen konnte, nämlich erzählend wieder für Weltvertrauen zu werben und Weltvertrauen zu schaffen". Man kann darin freilich auch einen gefährlichen Eskapismus sehen - ob man Handke als schwierig erachtet, oder ihm attestiert, Schwieriges zu leisten, ist auch eine Frage der Perspektive. Oder aber man kann die Vermutung formulieren, dass solche Zuschreibungen den Blick auf die Sache, wie auch bei Cotten, eher verstellen, und so drängen sich verschiedene Fragen auf: Wieso arbeitet sich Cotten an einem Autor mit solchem Ruf ab? Weshalb liest sie ihn? Was hat sein Nerven mit ihrem Nerven zu tun? Und was ist das eigentlich, 'nerven'? Zeit also für eine Rekonstruktion von Cottens Handke-Lektüre.
Bei Osnabrück glazial übertiefter tertiärer geologischer Graben. Im oberen Teil mit pleistozäner Sand- oder Kiesfüllung. Örtlichkeit für einen Stau- oder Grundwassersee? Niederschlags- und Verdunstungsverhältnisse. Oberirdischer Abfluß. Grundwasserspiegelpläne für maximale Grundwasserstände. Bedeutung des unterirdischen Abflusses. Geologisch-hydrologische Voraussetzungen ließen nur Grundwassersee, den heutigen Rubbenbruchsee, zu.
Der Sudenfelder Sattel des Osningsandsteins bei Hagen a.T.W. (Landkreis Osnabrück) : (Teil I)
(1980)
Zur besseren lJbersicht wird an der bewährten Gliederung WEGNERs in den kalkigen oberkreidezeitlichen, vom Münsterland aus betrachtet 1. Teutoburger Wald-Kamm und in den dicht hinter ihm parallel verlaufenden 2. Teutoburger Wald-Kamm, in den sandigen unterkreidezeitlichen Teutoburger Wald-Kamm des Osningsandsteins, festgehalten. Von dieser Gliederung unterscheidet sich der Abschnitt westlich von Bad Iburg bis nach Tecklenburg auffällig derart, daß sich auf einer Längserstreckung von 17 km beide Kämme bis auf 2,5 km voneinander entfernen, um einen Raum mit einem Faltenbau des Osningsandsteins freizugeben.
Wer von Lengerich kommend nach Überquerung des Ober-Kreide-Kalkrückens des Teutoburger Waldes auf dem Hof Herkendorf nach den Herkensteinen fragt, ist überrascht zu erfahren, daß diese an ganz anderer Stelle liegen (Abb. 1). Nur wenigen bekannt, stehen sie im heute zu Tecklenburg gehörenden Ledde-Oberberge und sind vom Hof Herkendorf 2,5 km entfernt.
Im Zusammenhang mit der Planung des Rubbenbruchsees in Osnabrück waren hydrogeologische Untersuchungen erforderlich, die in den Jahren 1959-1961 durchgeführt wurden. Der zunächst als Stauanlage vorgesehene See sollte in geologischer Hinsicht einen allseits möglichst dichten Untergrund zur Voraussetzung haben, während sich die hydrologischen Untersuchungen mit der Wasserbilanz des Sees in mehreren Größen auseinandersetzten.
Im Ibbenbürener Tal, das im Süden vom Teutoburger Wald und im Norden vom Schafberg begrenzt wird, wurden an hand von 91 Wasserproben die geohydrologischen Verhältnisse untersucht. Die dabei benutzte Chlorid-Methode ergab, daß an der Oberfläche geogenminerogenes Gruncwasserfehlt und die geogen-ombrogenen Wässer nur mit ca. 18% vorhanden sind. Über 80% der untersuchten Gewässer müssen als anthropogen eingestuft werden. Es wird eine Karte des Ibbenbürener Tales mit der flächenmäßigen Verteilung der einzelnen Wassertypen vorgelegt.
An Hand der im einzelnen dargelegten Anschauungen der pflanzlichen Gesellschaftslehre der Neobotanik wird das Vorhaben verfolgt, gleichartige Wege für die Beantwortung soziologischer Fragen bei fossilen Floren auf paläobotanischer Grundlage zu finden. Geologisch-historisch ergeben sich dabei zwei Probleme, welche dem Neobotaniker als Zeitgenossen seiner Objekte unbekannt sind und für ihn aus der heute vorliegenden Situation gar nicht entstehen können. Um paläobotanische Soziologie überhaupt betreiben zu können, sind für die Realität einer fossilen Pflanzengemeinschaft erst zwei Voraussetzungen zu gewinnen: die Synchronie, die regionale Gleichaltrigkeit der Gesteinsschicht, in oder auf der die fossile Flora bis heute konserviert wurde, der Individuums beg riff, der erst auf Grund der jetzigen Fundumstände geprägt werden kann. Unter Auswertung von Untertage-Vorkommen von fossilreichen Pflanzenschichten im gefalteten Westfal A und B des mittleren und nördlichen Ruhrgebietes wurde von zwei Mitarbeitern des Autors eine größere Anzahl von Synchronen ermittelt und unter Formung und Präzisierung des Individuumsbegriffes die Möglichkeit qeschaffen. die Paläosoziologie für einen Teil der oberkarbonischen Pflanzenwelt der euramerischen Floraprovinz zu erarbeiten.
Im Tecklenburger Land Nordwestfalens ist wie auch in anderen mitteleuropäischen Felslandschaften die Morphologie im großen und im kleinen durch ältere bruchtektonische und durch jüngere exogene, von der Verwitterung mit der Gravitation getragene Kräfte bestimmt. Sichtbare Zeichen für ihre Auswirkungen sind Lagestörungen im geschlossenen Gesteinskörper und an Felsen. Sie äußern sich in Texturen, bei denen zwischen Zeugen für bruchtektonische und für atektonische, felsmechanische Entstehung zu unterscheiden ist. Die bruchtektonischen Texturen treten als Längs- und Querklüfte und als Auf- und Oberschiebungen hervor, die im gewachsenen Gesteinskörper gebannt sind. Die felsmechanischen Texturen setzen über die heutige Erdoberfläche emporragende Felsen voraus, die in den Dörenther Klippen aus dem nach ihnen benannten Dörenther Sandstein der unterkretazischen Osning-Sandstein-Folge bestehen. Je nach dem Vorhandensein freier Flächen sind die Bewegung auslösenden felsmechanischen Texturen im oder gegen das Schichteinfallen und auch im Streichen angeordnet. Die Gravitation löste die Rißbildung aus und bestimmte den weiteren Verlauf und Zerfall nach Art der Hangzerreißung. Die felsmechanischen Bewegungen knüpfen teilweise an bruchtektonische Texturen an, die in reiner Form unter der Verwitterungszone im festen Gestein des Gravenhorster Sandsteins, ebenfalls der Osningsandstein-Folge zugehörig, erhalten sind. Abschließend wird die Entstehung der bruchtektonischen und der felsmechanischen Texturen in den geologischen Zeitablauf eingegliedert. Die Bruch-Tektonik fällt genetisch mit der Osning-Tektonik zusammen, die in der subherzynischen Faltungsphase am Ausgang der altalpidischen Faltungsära entstand. Die heute vorliegende Felsmechanik dürfte seit dem Abtauen des Saaleeises entstanden sein und bestimmt jetzt und weiter das morphologische Bild der Dörenther Klippen im Tecklenburger Land.