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Erasmus of Rotterdam was a scholar with a broad range of interests living in the Renaissance and Reformation period, and he has become the eponymous figurehead of a European university mobility programme initiated thirty years ago. With reference to the partnership between the University of Ostrava (Czech Republic) and the Zittau/Görlitz University of Applied Sciences (Germany), this paper demonstrates the key importance of this programme for university courses in translation studies, showing how the programme is implemented in line with Erasmus of Rotterdam's ideas and convictions.
This article deals with the literary depiction of Prince Felix Lichnowsky viewed through the lens of the Czech translation of the verse epic Atta Troll. The translation was published in 1953 and is linked to the translation work of Eduard Petiška. The aim of the study is to illuminate the correspondences or differences arising from the comparison of the original version with its translation.
This study compares the dramas König Ottokars Glück und Ende by the Austrian dramatist Franz Grillparzer and Král Přemysl Otakar Druhý by the Czech writer František Zavřel. The focus is on the character of the Bohemian King Otakar II. The king is depicted by both authors as a strong and remarkable figure, but while Grillparzer presents him as an anti-hero who falls victim to his own ruthless politics, Zavřel shows him to be a form of superman, whose downfall is caused by the pettiness of those around him. The study explores these differences and seeks to explain their origins
The article presents the first German-Czech handbook and textbook about forestry (written by Wenzel Elias Lenhardt). The text is of particular interest due to the language situation and the practical use of both German and Czech in the Bohemian Crown Lands during the 18th century. The paper also discusses several aspects of the handbook and textbook - including the author and the addressee from a pragmalinguistic perspective - and summarizes the results of an analysis of its textual characteristics, writing style, syntax and lexis.
In Europe, anthroponyms have undergone a complex development, as simple one-word personal names have developed into multi-word structures containing one, two or more personal names and a stable surname. The article predominantly characterizes the development of surnames on the basis of their origin. Attention is also paid to different trends in the development of personal names. The article analyses this phenomenon from various perspectives, using an example of one specific living person’s anthroponyms.
Due to its specific features, the German participle has numerous functions and uses in word-formation. As partially deverbalized adjectives, participles take on the syntactic role of an adjective while at the same time retaining the valency of a verb. The paper presents the various steps in an analysis using graded (partial) corpora. Drawing on research into the properties and functions of various participle forms, it explores their specific uses in texts.
Objects that are semantically related to the visual scene context are typically better recognized than unrelated objects. While context effects on object recognition are well studied, the question which particular visual information of an object’s surroundings modulates its semantic processing is still unresolved. Typically, one would expect contextual influences to arise from high-level, semantic components of a scene but what if even low-level features could modulate object processing? Here, we generated seemingly meaningless textures of real-world scenes, which preserved similar summary statistics but discarded spatial layout information. In Experiment 1, participants categorized such textures better than colour controls that lacked higher-order scene statistics while original scenes resulted in the highest performance. In Experiment 2, participants recognized briefly presented consistent objects on scenes significantly better than inconsistent objects, whereas on textures, consistent objects were recognized only slightly more accurately. In Experiment 3, we recorded event-related potentials and observed a pronounced mid-central negativity in the N300/N400 time windows for inconsistent relative to consistent objects on scenes. Critically, inconsistent objects on textures also triggered N300/N400 effects with a comparable time course, though less pronounced. Our results suggest that a scene’s low-level features contribute to the effective processing of objects in complex real-world environments.
The aim of this paper is to show that the users of social media and the members of various networks make great efforts to achieve as original, innovative and creative ways of expression as possible. In this respect, the social networking site called Facebook is no exception. However, what differs is the occasions on which the texts are created (in the form of contributions, postings, comments etc.), their particular language forms as well as their distance in relation to both private and public virtual communities. The corpus explored comprises the profiles of different Facebook-users who release their birthday wishes online
Background: Transient elastography (TE) has been validated as an effective noninvasive tool for the assessment of liver fibrosis. The XL probe is a new probe that was initially designed for use in patients with obesity. A meta-analysis was performed to assess the feasibility and efficacy of TE using the XL probe.
Methods: In September 2016, we systematically searched the PubMed and Science Direct search engines. The feasibility of TE was evaluated based on the failure rate and the results of the unreliable liver stiffness measurement (LSM). The efficacy of TE was measured using sensitivity, specificity, and summary receiver-operating characteristic as measures/indices assessed in different stages of fibrosis. Heterogeneity was measured using the chi-squared test and the Q-statistic. We used the 95% confidence interval (95% CI) as an effect measure.
Results: We included 8 studies in the meta-analysis. When the XL was compared to the M probe, the former showed a lower risk of failure rate [relative risk (RR) 0.24, 95% CI 0.14–0.38]. In patients with a body mass index ≥30 kg/m2, the XL probe showed a statistically significantly lower risk of failure rate (RR 0.16, 95% CI 0.08–0.32) but no significant improvement (RR 0.76, 95% CI 0.50–1.16) in the unreliable LSM result. In patients showing liver fibrosis stage ≥F2, the XL probe showed a sensitivity of 0.56 (95% CI 0.39–0.72), specificity of 0.71 (95% CI 0.61–0.79), and an area under the curve (AUC) of 0.71. The results observed in patients with liver fibrosis stage F4 were more promising with a sensitivity of 0.84 (95% CI 0.76–0.90), specificity of 0.78 (95% CI 0.70–0.84), and an AUC of 0.88.
Conclusion: TE using the XL probe demonstrates significant diagnostic utility in patients with liver fibrosis and is likely to be more reliable than the M probe in patients with obesity. Large prospective multicenter studies are, however, necessary to establish the new cut-off values to be used for the XL probe in patients with obesity.
The paper presents the possibilities for analyzing deverbal derivatives from verbs ending in -ier(en); in many cases these exist as doublets, with the suffix -ung and/or the suffix -(at)ion. Based on selected examples of these doublets, the paper demonstrates how both monolingual and bilingual dictionaries fail to take sufficient account of the semantic differences between such competing forms. The author also presents research questions connected with this issue, and outlines a methodology for addressing these questions based on metalexicographic and corpus analysis; this methodology is demonstrated using the example of the doublet Diskrimination and Diskriminierung
The access to information on the dynamic behaviour of large proteins is usually hindered as spectroscopic methods require the site-specific attachment of biophysical probes. A powerful emerging tool to tackle this issue is amber codon suppression. Till date, its application on large and complex multidomain proteins of MDa size has not been reported. Herein, we systematically investigate the feasibility to introduce different non-canonical amino acids into a 540 kDa homodimeric fatty acid synthase type I by genetic code expansion with subsequent fluorescent labelling. Our approach relies on a microplate-based reporter assay of low complexity using a GFP fusion protein to quickly screen for sufficient suppression conditions. Once identified, these findings were successfully utilized to upscale both the expression scale and the protein size to full-length constructs. These fluorescently labelled samples of fatty acid synthase were subjected to initial biophysical experiments, including HPLC analysis, activity assays and fluorescence spectroscopy. Successful introduction of such probes into a molecular machine such as fatty acid synthases may pave the way to understand the conformational variability, which is a primary intrinsic property required for efficient interplay of all catalytic functionalities, and to engineer them.
The article presents two surgical texts written in Strasbourg around 1500. The author of the first text is Hieronymus Brunschwig, and the second is by Hans Gersdorff. Although Gersdorff's book is more like a teaching text, a set of normative instructions in the manner of (legally binding) municipal records, it was published under the name 'Feldbuch'. The publisher may have chosen this designation under the influence of texts named Feldbücher, originating in the Moravian-Silesian region, which were originally intended as manuals for barber surgeons working on battlefields
Based on increasing evidence suggesting that MS pathology involves alterations in bioactive lipid metabolism, the present analysis was aimed at generating a complex serum lipid-biomarker. Using unsupervised machine-learning, implemented as emergent self-organizing maps of neuronal networks, swarm intelligence and Minimum Curvilinear Embedding, a cluster structure was found in the input data space comprising serum concentrations of d = 43 different lipid-markers of various classes. The structure coincided largely with the clinical diagnosis, indicating that the data provide a basis for the creation of a biomarker (classifier). This was subsequently assessed using supervised machine-learning, implemented as random forests and computed ABC analysis-based feature selection. Bayesian statistics-based biomarker creation was used to map the diagnostic classes of either MS patients (n = 102) or healthy subjects (n = 301). Eight lipid-markers passed the feature selection and comprised GluCerC16, LPA20:4, HETE15S, LacCerC24:1, C16Sphinganine, biopterin and the endocannabinoids PEA and OEA. A complex classifier or biomarker was developed that predicted MS at a sensitivity, specificity and accuracy of approximately 95% in training and test data sets, respectively. The present successful application of serum lipid marker concentrations to MS data is encouraging for further efforts to establish an MS biomarker based on serum lipidomics.
A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets
(2018)
NKp46 (CD335) is a surface receptor shared by both human and mouse natural killer (NK) cells and innate lymphoid cells (ILCs) that transduces activating signals necessary to eliminate virus-infected cells and tumors. Here, we describe a spontaneous point mutation of cysteine to arginine (C14R) in the signal peptide of the NKp46 protein in congenic Ly5.1 mice and the newly generated NCRB6C14R strain. Ly5.1C14R NK cells expressed similar levels of Ncr1 mRNA as C57BL/6, but showed impaired surface NKp46 and reduced ability to control melanoma tumors in vivo. Expression of the mutant NKp46C14R in 293T cells showed that NKp46 protein trafficking to the cell surface was compromised. Although Ly5.1C14R mice had normal number of NK cells, they showed an increased number of early maturation stage NK cells. CD49a+ILC1s were also increased but these cells lacked the expression of TRAIL. ILC3s that expressed NKp46 were not detectable and were not apparent when examined by T-bet expression. Thus, the C14R mutation reveals that NKp46 is important for NK cell and ILC differentiation, maturation and function.
Objective: The correlation of depleted blood through midline shift in acute subdural hematoma remains the most reliable clinical predictor to date. On the other hand, patient’s ABO blood type has a profound impact on coagulation and hemostasis. We conducted this study to evaluate the role of patient’s blood type in terms of incidence, clinical course and outcome after acute subdural hematoma bleeding.
Methods: 100 patients with acute subdural hematoma treated between 2010 and 2015 at the author’s institution were included. Baseline characteristics and clinical findings including Glasgow coma scale, Glasgow outcome scale, hematoma volume, rebleeding, midline shift, postoperative seizures and the presence of anticoagulation were analyzed for their association with ABO blood type.
Results: Patient’s with blood type O were found to have a lower midline shift (p<0.01) and significantly less seizures (OR: 0.43; p<0.05) compared to non-O patients. Furthermore, patients with blood type A had the a significantly higher midline shift (p<0.05) and a significantly increased risk for postoperative seizures (OR: 4.01; p<0.001). There was no difference in ABO blood type distribution between acute subdural hematoma patients and the average population.
Conclusion: The ABO blood type has significant influence on acute subdural hematoma sequelae. Patient’s with blood type O benefit in their clinical course after acute subdural hematoma whereas blood type A patients are at highest risk for increased midline shift and postoperative seizures. Further studies elucidating the biological mechanisms of blood type depended hemostaseology and its role in acute subdural hematoma are required for the development of an appropriate intervention.
Locomotion circuits developed in simple animals, and circuit motifs further evolved in higher animals. To understand locomotion circuit motifs, they must be characterized in many models. The nematode Caenorhabditis elegans possesses one of the best-studied circuits for undulatory movement. Yet, for 1/6th of the cholinergic motor neurons (MNs), the AS MNs, functional information is unavailable. Ventral nerve cord (VNC) MNs coordinate undulations, in small circuits of complementary neurons innervating opposing muscles. AS MNs differ, as they innervate muscles and other MNs asymmetrically, without complementary partners. We characterized AS MNs by optogenetic, behavioral and imaging analyses. They generate asymmetric muscle activation, enabling navigation, and contribute to coordination of dorso-ventral undulation as well as anterio-posterior bending wave propagation. AS MN activity correlated with forward and backward locomotion, and they functionally connect to premotor interneurons (PINs) for both locomotion regimes. Electrical feedback from AS MNs via gap junctions may affect only backward PINs.
This paper takes as its starting point several statements by Gottfried Wilhelm Leibniz on the role of the German language in literary and scholarly life during Leibniz's era. The languages of scholarship were Latin and French, and Leibniz himself published in both these languages. German was the language of practical life. Viewed from this perspective, it was almost inevitable that medieval and early modern medicine - not in the sense of academic theory, but as a practical activity - developed its own fully-fledged specialist language, which was largely based on the vernacular. In her studies of the language of historical medicine, Lenka Vaňková has shown how such vernacular language was (and potentially still is) able to function in specialist domains
On history in the present day. Laudatio to Lenka Vaňková.
This paper takes as its starting point several statements by Gottfried Wilhelm Leibniz on the role of the German language in literary and scholarly life during Leibniz's era. The languages of scholarship were Latin and French, and Leibniz himself published in both these languages. German was the language of practical life. Viewed from this perspective, it was almost inevitable that medieval and early modern medicine - not in the sense of academic theory, but as a practical activity - developed its own fully-fledged specialist language, which was largely based on the vernacular. In her studies of the language of historical medicine, Lenka Vaňková has shown how such vernacular language was (and potentially still is) able to function in specialist domains.
Os materiais audiovisuais, como filmes e seriados, proporcionam ao professor a oportunidade de apontar exemplos de diferentes tipos de falantes da língua-alvo: tanto falantes nativos (comumente tomados como modelo) quanto interculturais (HOUSE 2007), sendo estes falantes não nativos que se apropriaram adequadamente da língua estrangeira para a comunicação. Apresentar falantes interculturais ao aluno é importante para que ele possa romper com a concepção de falante nativo ideal como modelo de aprendizagem (RAJAGOPALAN 2012); por essa razão, é imprescindível que esse tipo de personagem seja representado adequadamente em seriados e filmes. Tendo isso em vista, pretendemos analisar, neste trabalho, os seriados Erste Wege in Deutschland e Jojo sucht das Glück, no que se refere a suas protagonistas (ambas, supostamente, falantes interculturais). Foram analisados, respectivamente, dois e cinco episódios das séries, buscando refletir sobre as protagonistas com base na caracterização de falante intercultural nos estudos da área (BYRAM, GRIBKOVA E STARKEY 2002; HOUSE 2007; OLIVEIRA 2012). Os resultados apontam para uma representação artificial dessas personagens, pois elas reproduzem, de forma geral, características típicas de um falante idealizado, o qual gera imagens estereotipadas da língua-alvo.
This paper investigates the concept(s) of intercultural competence held by undergraduate students from teacher education courses in English and German languages. To this end, first and fourth year undergraduates of English and German from a federal university in Rio de Janeiro answered two versions of a questionnaire designed to lead students to inductively formulate what they understood as intercultural competence and how they would help their future students develop this competence. Responses were submitted to content analysis and the four groups were compared. Results show that students of English and German who participated in this study hold different perspectives on intercultural competence and one of the reasons for that may be attributed to their educational background