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Poster presentation: NO-sensitive guanylyl cyclases (GC) are the principal receptors for nitric oxide (NO) and convert GTP into the second messenger cGMP. We showed that GC is prone to tyrosine phosphorylation in COS1 cells overexpressing the human holoenzyme. Similar results were obtained in PC12 cells and in rat aortic tissue slices. The major phosphorylation site was mapped to position 192 in the regulatory domain of the beta1 subunit. Tyrosine phosphorylation of GC was reduced in the presence of the inhibitors PP1 and PP2 indicating that Src-like kinases are critically involved in phosphorylation. Moreover, co-immunoprecipitation experiments revealed an interaction between Src and GC. To further analyse the relevance of this posttranslational modification we generated a phospho-specific antibody raised against pTyr192. This antibody clearly distinguishes between phosphorylated and non-phosphorylated GC and may be a powerful tool to analyse the subcellular localisation of the phosphorylated enzyme.
Poster presentation NO-sensitive guanylyl cyclases (soluble guanylyl cyclase, sGC) are among the key regulators of intracellular cGMP concentration. The mechanisms underlying NO-mediated activation of sGC are quite well understood, however, little is known about the fine-tuning of sGC activity through alternative mechanisms such as protein phosphorylation. Several reports have demonstrated the reversible phosphorylation of sGC on serine/threonine residues, and it has been speculated, though not experimentally proven, that sGC might also be phosphorylated on tyrosine residues. Using broad-spectrum phosphatase inhibitors we were able to demonstrate tyrosine phosphorylation at Tyr192 of the beta 1 subunit of human sGC in COS1 cells. This residue forms part of a sequence segment (YEDL) representing a preferential binding site for SH2 domains of Src-like kinases. Pull-down assays and co-immunoprecipitation experiments showed that Src can indeed bind via its SH2 domain to pTyr192 of beta 1 indicating that tyrosine phosphorylation of sGC may be followed by recruitment of Src-like kinases to the phosphorylated beta 1 subunit. In support of this hypothesis, immunofluorescence studies showed a colocalization of overexpressed sGC and Src at the plasma membrane of COS1 and Hela cells. Together, our results point to an unexpected crosstalk between tyrosine kinase pathway(s) and the NO/cGMP signalling cascade which may result in translocation of the predominantly cytosolic sGC to the cytosolic face of the plasma membrane.
Seabirds in the UK were generally more productive in 2005 than in 2004, when productivity for many species reached an all-time low. A presumed scarcity of sandeels in 2004, especially in the North Sea, led to widespread starvation of chicks in the Northern Isles and in many places along the east coast of Britain (there is also recent evidence that prey fish were of unusually low energy content in 2004 around SE Scotland). The likely knock-on effect for 2005 was that there were few larger sandeels present (those that hatched in 2004) and it is thought that feeding on these fish allow adults to attain breeding condition in spring. This food scarcity and a cold spring led to what was among the latest breeding seasons on record. However, a late appearance of young sandeels allowed some chicks to fledge, and alternative prey species (such as sprat and small haddock) were taken also. However, it is thought that some chicks starved in this late season, as sandeels become unavailable in late summer, when they settle on the seabed. Unusually, 2005 was a very poor breeding season for many species in NW Scotland, which was spared the food shortages of 2004 and previous years; preferred prey during chick rearing were scarce in this region in 2005.
FIFO is the most prominent queueing strategy due to its simplicity and the fact that it only works with local information. Its analysis within the adversarial queueing theory however has shown, that there are networks that are not stable under the FIFO protocol, even at arbitrarily low rate. On the other hand there are networks that are universally stable, i.e., they are stable under every greedy protocol at any rate r < 1. The question as to which networks are stable under the FIFO protocol arises naturally. We offer the first polynomial time algorithm for deciding FIFO stability and simple-path FIFO stability of a directed network, answering an open question posed in [1, 4]. It turns out, that there are networks, that are FIFO stable but not universally stable, hence FIFO is not a worst case protocol in this sense. Our characterization of FIFO stability is constructive and disproves an open characterization in [4].
Language planning for the Irish language in the Republic of Ireland has featured prominently in international language policy and planning literature over the years. Researchers in the field may not be up to date, however, with recent developments in the area of Irish language planning and their impact on the language ecology. This monograph describes the language planning situation in the Republic of Ireland in its historical and social contexts as well as delineating language policy and planning for the Irish language implemented over the past number of years, showing developments in education, community, media, religion and local politics.
The higher classification of the Nocluoidea (Oenosandridae, Doidae, Notodontidae, Strepsimanidae, Nolidae, lymanlriidae, Arctiidae, Erebidae, Micronoctuidae, and Noctuidae) is reviewed from the perspective of the classification proposed by KITCHING and RAWLINS (1998). Several taxa are reinstated, described as new, synonymised, or redescribed. Some characters that have been inadequately described, poorly understood, or misinterpreted, are redescribed and discussed. One family, two subfamilies, four tribes, and three subtribes are proposed as new. Available family-group names of Noctuoidea are listed In an appendix.
The epistemic step
(2005)
DP is not a scope island
(2005)
This paper advances a purely presuppositional analysis of intonation. I first show that a inspiring recent article by Geurts and van der Sandt (Theoretical Linguistics, 2004) that pursues the same goal cannot account for multiple foci. Then, I show that if it is assumed that destressed rather than focussed material is semantically marked, multiple foci are accounted for correctly.
Trubetzkoy's recognition of a delimitative function of phonology, serving to signal boundaries between morphological units, is expressed in terms of alignment constraints in Optimality Theory, where the relevant constraints require specific morphological boundaries to coincide with phonological structure (Trubetzkoy 1936, 1939, McCarthy & Prince 1993). The approach pursued in the present article is to investigate the distribution of phonological boundary signals to gain insight into the criteria underlying morphological analysis. The evidence from English and Swedish suggests that necessary and sufficient conditions for word-internal morphological analysis concern the recognizability of head constituents, which include the rightmost members of compounds and head affixes. The claim is that the stability of word-internal boundary effects in historical perspective cannot in general be sufficiently explained in terms of memorization and imitation of phonological word form. Rather, these effects indicate a morphological parsing mechanism based on the recognition of word-internal head constituents. Head affixes can be shown to contrast systematically with modifying affixes with respect to syntactic function, semantic content, and prosodic properties. That is, head affixes, which cannot be omitted, often lack inherent meaning and have relatively unmarked boundaries, which can be obscured entirely under specific phonological conditions. By contrast, modifying affixes, which can be omitted, consistently have inherent meaning and have stronger boundaries, which resist prosodic fusion in all phonological contexts. While these correlations are hardly specific to English and Swedish it remains to be investigated to which extent they hold cross-linguistically. The observation that some of the constituents identified on the basis of prosodic evidence lack inherent meaning raises the issue of compositionality. I will argue that certain systematic aspects of word meaning cannot be captured with reference to the syntagmatic level, but require reference to the paradigmatic level instead. The assumption is then that there are two dimensions of morphological analysis: syntagmatic analysis, which centers on the criteria for decomposing words in terms of labelled constituents, and paradigmatic analysis, which centers on the criteria for establishing relations among (whole) words in the mental lexicon. While meaning is intrinsically connected with paradigmatic analysis (e.g. base relations, oppositeness) it is not essential to syntagmatic analysis.
Dictionaries contain lexicographic data whose occurrence is restricted to certain geo-graphical areas, subject fields, professions, etc. It is part of the duties of the lexicographer to give an account of such deviations to ensure a successful retrieval of the information on the part of the user. This contribution presents a discussion on labelling issues in the Dictionnaire Français–Mpongwé. Although the main focus is on the presentation of different types of labelling as well as problems in labelling, textual condensation procedures and mediostructural representations (to-gether with some aspects of the user perspective) are also critically evaluated. It is shown that these procedures reveal some inconsistencies which are not accounted for in the outer texts (front matter and back matter texts) of the dictionary. Finally suggestions are made for the improvement of the access structure of this dictionary.
In his paper, "The Canonization of German-language Digital Literature," Florian Hartling discusses "Net Literature," a relatively young phenomenon, that has its roots in experimental visual and concrete poetry and hypertext. With the use of new media technology, this new genre of literature has acquired much interest and is now considered to be one of the most important influences in contemporary art. Not only does Net Literature connect sound, video, and animation with interactivity and allows new forms of artistic expression, it also impacts significantly on the traditional functions of the literary system. Hartling suggests that, in relation to Net Literature, the notion of the "death of the author" gives birth to the "writing reader." Hartling presents the results of his study where he applies the concept of "canon" to German-language Net Literature and where he attempts to find out whether, in this new form of literature, a "canon" has already been formed. Based on Karl Erik Rosengren's framework of "mention technique," a sample of Germanlanguage reviews of Net Literature was analyzed. The study intends to test the applicability of Rosengren's method to the analysis of Net Literature, that is, whether it is valid to use a method that was originally developed for the empirical study of the traditional literary canon for the study of an emergent Net Literature.