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Background Medical students come into contact with infectious diseases early on their career. Immunity against vaccine-preventable diseases is therefore vital for both medical students and the patients with whom they come into contact. Methods The purpose of this study was to compare the medical history and serological status of selected vaccine-preventable diseases of medical students in Germany. Results The overall correlation between medical history statements and serological findings among the 150 students studied was 86.7 %, 66.7 %, 78 % and 93.3 % for measles, mumps, rubella and varicella, conditional on sufficient immunity being achieved after one vaccination. Conclusions Although 81.2 % of the students medical history data correlated with serological findings, significant gaps in immunity were found. Our findings indicate that medical history alone is not a reliable screening tool for immunity against the vaccine-preventable diseases studied.
Wassergefiltertes Infrarot A (wIRA) ist eine spezielle Form der Wärmestrahlung mit hohem Eindringvermögen in das Gewebe bei geringer thermischer Oberflächenbelastung. wIRA wirkt sowohl über thermische und temperaturabhängige als auch über nicht-thermische und temperaturunabhängige Effekte. wIRA erzeugt ein therapeutisch nutzbares Wärmefeld im Gewebe und steigert Temperatur und Sauerstoffpartialdruck im Gewebe sowie die Gewebedurchblutung. Diese drei Faktoren sind entscheidend für eine ausreichende Versorgung des Gewebes mit Energie und Sauerstoff und deshalb auch für alle Prozesse der Regeneration und Heilung, wie Wundheilung und Infektionsabwehr. wIRA vermag Schmerzen deutlich zu mindern (mit bemerkenswert niedrigerem Analgetikabedarf) und eine erhöhte Sekretion (bei Wunden oder z.B. tracheal/bronchial) und Entzündung herabzusetzen sowie positive immunmodulierende Effekte zu zeigen. wIRA kann sowohl bei akuten als auch bei chronischen Wunden einschließlich infizierter Wunden die Wundheilung beschleunigen oder bei stagnierender Wundheilung verbessern. Selbst der normale Wundheilungsprozess kann verbessert werden. wIRA kann zur Therapie von hartnäckigen vulgären Hand- und Fußwarzen (ein Therapiezyklus mit kontinuierlicher Keratolyse mit Salizylsäurepflaster, unblutiger Kürettage, einer wIRA-Bestrahlung von 30 Minuten pro Woche für 6-9 Wochen), bei Herpes labialis, Herpes zoster, Condylomata acuminata, Sklerodermie, Morphea und Akne papulopustulosa eingesetzt werden. wIRA kann zur Resorptionsverbesserung topischer Dermatika und Substanzen (wie Cortison oder lokaler Anästhetika) als Alternative zu einem Okklusivverband verwendet werden. wIRA kann im Rahmen einer photodynamischen Therapie zusammen mit einer oder mehreren Wirkbanden im sichtbaren Bereich und einem topisch aufgetragenen Photosensibilisator bei aktinischen Keratosen eingesetzt werden. Im Rahmen von Physiotherapie, Sportmedizin und Orthopädie kann die klinische Anwendung von wIRA präventiv, therapeutisch, regenerativ oder rehabilitativ erfolgen. wIRA kann eingesetzt werden bei muskulären Verspannungen, Myogelosen, Lumbago, Erkrankungen des rheumatischen Formenkreises, M. Bechterew, Arthrosen, Arthritiden, Kontusionen, Fibromyalgie (vorzugsweise wIRA in Kombination mit Bewegung, d.h. wIRA mit leichter Ergometerarbeit), zur Regeneration nach Sport (wIRA allein oder wIRA in Kombination mit Bewegung), zur postoperativen Rehabilitation und zur Förderung der Lipolyse (wIRA in Kombination mit Bewegung). In der Neonatologie kann wIRA zur Aufrechterhaltung oder Erhöhung der Körpertemperatur und zum Erzeugen eines "Wärmedepots" vor einem erforderlichen Transport des Neugeborenen verwendet werden. In der Onkologie kann wIRA für eine (lokale oder systemische) Hyperthermie in Kombination mit Strahlentherapie oder Chemotherapie eingesetzt werden.
In the context of information theory, the term Mutual Information has first been formulated by Claude Elwood Shannon. Information theory is the consistent mathematical description of technical communication systems. To this day, it is the basis of numerous applications in modern communications engineering and yet became indispensable in this field. This work is concerned with the development of a concept for nonlinear feature selection from scalar, multivariate data on the basis of the mutual information. From the viewpoint of modelling, the successful construction of a realistic model depends highly on the quality of the employed data. In the ideal case, high quality data simply consists of the relevant features for deriving the model. In this context, it is important to possess a suitable method for measuring the degree of the, mostly nonlinear, dependencies between input- and output variables. By means of such a measure, the relevant features could be specifically selected. During the course of this work, it will become evident that the mutual information is a valuable and feasible measure for this task and hence the method of choice for practical applications. Basically and without the claim of being exhaustive, there are two possible constellations that recommend the application of feature selection. On the one hand, feature selection plays an important role, if the computability of a derived system model cannot be guaranteed, due to a multitude of available features. On the other hand, the existence of very few data points with a significant number of features also recommends the employment of feature selection. The latter constellation is closely related to the so called "Curse of Dimensionality". The actual statement behind this is the necessity to reduce the dimensionality to obtain an adequate coverage of the data space. In other word, it is important to reduce the dimensionality of the data, since the coverage of the data space exponentially decreases, for a constant number of data points, with the dimensionality of the available data. In the context of mapping between input- and output space, this goal is ideally reached by selecting only the relevant features from the available data set. The basic idea for this work has its origin in the rather practical field of automotive engineering. It was motivated by the goals of a complex research project in which the nonlinear, dynamic dependencies among a multitude of sensor signals should be identified. The final goal of such activities was to derive so called virtual sensors from identified dependencies among the installed automotive sensors. This enables the real-time computability of the required variable without the expenses of additional hardware. The prospect of doing without additional computing hardware is a strong motive force in particular in automotive engineering. In this context, the major problem was to find a feasible method to capture the linear- as well as the nonlinear dependencies. As mentioned before, the goal of this work is the development of a flexibly applicable system for nonlinear feature selection. The important point here is to guarantee the practicable computability of the developed method even for high dimensional data spaces, which are rather realistic in technical environments. The employed measure for the feature selection process is based on the sophisticated concept of mutual information. The property of the mutual information, regarding its high sensitivity and specificity to linear- and nonlinear statistical dependencies, makes it the method of choice for the development of a highly flexible, nonlinear feature selection framework. In addition to the mere selection of relevant features, the developed framework is also applicable for the nonlinear analysis of the temporal influences of the selected features. Hence, a subsequent dynamic modelling can be performed more efficiently, since the proposed feature selection algorithm additionally provides information about the temporal dependencies between input- and output variables. In contrast to feature extraction techniques, the developed feature selection algorithm in this work has another considerable advantage. In the case of cost intensive measurements, the variables with the highest information content can be selected in a prior feasibility study. Hence, the developed method can also be employed to avoid redundance in the acquired data and thus prevent for additional costs.
Extrait des Minutes de la Secrétairerie d’Etat au quartier imperial de St Polten, le 22 brumaire an 14 Napoléon Empereur des Français et Roi d’Italie Sur le rapport de notre ministre de l’interieur Nous avons décreté et décretons ce qui suit Dispositions Générales Art. 1er l’Ecole existante dans le local du ci devant Gymnase Laurentien à Cologne, Departement de la Roer, prendra à l’avenir le titre d’Ecole secondaire communale de premier dégré II. Independamment de cette école, il en sera établi une autre sous le nom d’Ecole secondaire communale de second dégré. Le batiment et dépendances du collège des Jesuites du ci-devant couvent de St. Maximin sont concédé à la Ville de Cologne pour l’usage de cette école III. Tous les biens capitaux et revenus des fondations et bourses d’études des ci-devant Gymnases, et tous les biens capitaux et revenus provenant des Jésuites supprimés spécialement et originairement affectés aux établissemens d’instruction publiques de Cologne sont destinés à l’entretien des écoles de premier et second dégré de cette Ville
Die Folgen der französischen Vorherrschaft in Westdeutschland um 1800 sind ganz unterschiedlich bewertet worden. Manchmal schien der Verlust ‚nationaler‘ Selbstbestimmung entscheidend, so dass sie als düstere Jahre der Unterdrückung beschrieben wurden; manchmal stand der Aufbruch im Vordergrund, den die Modernisierung von Recht, Verwaltung und Wirtschaft, das Ende korporativer Autonomien und der Zuwachs an individuellen Mobilitätschancen zu ermöglichen schien. Auch im Bildungsbereich tritt beides vor Augen. Der Ersatz der ‚alten‘ Universitäten auf dem linken Rheinufer in Mainz und Köln durch neue Schultypen, zunächst Zentralschule und, in Köln, Sekundärschule, später durch preußische Gymnasien, ging mit zukunftsweisenden Reformen des Lehrplans und dem partiellen Abbau von Standesschranken einher. Zudem verzichteten die französischen Behörden auf die Verstaatlichung des bislang für die Bildung vorgesehenen Vermögens, und ermöglichten somit die Konsolidierung einer in Köln bis heute selbständigen Stiftung. Diese Neuordnung war aber zugleich Teil einer besatzungsähnlichen Politik, welche die in mancherlei Hinsicht erreichte Öffnung des höheren Schulwesens wieder einschränkte. Sie führte in beiden Städten zu vielen Jahren, in denen die Bürgerschaft auf den Komfort und das Prestige einer eigenen Universität verzichten musste: in Köln war das bis nach dem Ersten, in Mainz bis nach dem Zweiten Weltkrieg der Fall. ...
A new global crop water model was developed to compute blue (irrigation) water requirements and crop evapotranspiration from green (precipitation) water at a spatial resolution of 5 arc minutes by 5 arc minutes for 26 different crop classes. The model is based on soil water balances performed for each crop and each grid cell. For the first time a new global data set was applied consisting of monthly growing areas of irrigated crops and related cropping calendars. Crop water use was computed for irrigated land and the period 1998 – 2002. In this documentation report the data sets used as model input and methods used in the model calculations are described, followed by a presentation of the first results for blue and green water use at the global scale, for countries and specific crops. Additionally the simulated seasonal distribution of water use on irrigated land is presented. The computed model results are compared to census based statistical information on irrigation water use and to results of another crop water model developed at FAO.
A data set of monthly growing areas of 26 irrigated crops (MGAG-I) and related crop calendars (CC-I) was compiled for 402 spatial entities. The selection of the crops consisted of all major food crops including regionally important ones (wheat, rice, maize, barley, rye, millet, sorghum, soybeans, sunflower, potatoes, cassava, sugar cane, sugar beets, oil palm, rapeseed/canola, groundnuts/peanuts, pulses, citrus, date palm, grapes/vine, cocoa, coffee), major water-consuming crops (cotton), and unspecified other crops (other perennial crops, other annual crops, managed grassland). The data set refers to the time period 1998-2002 and has a spatial resolution of 5 arc minutes by 5 arc minutes which is 8 km by 8 km at the equator. This is the first time that a data set of cell-specific irrigated growing areas of irrigated crops with this spatial resolution was created. The data set is consistent to the irrigated area and water use statistics of the AQUASTAT programme of the Food and Agriculture Organization of the United Nations (FAO) (http://www.fao.org/ag/agl/aglw/aquastat/main/index.stm) and the Global Map of Irrigation Areas (GMIA) (http://www.fao.org/ag/agl/aglw/aquastat/irrigationmap/index.stm). At the cell-level it was tried to maximise consistency to the cropland extent and cropland harvested area from the Department of Geography and Earth System Science Program of the McGill University at Montreal, Quebec, Canada and the Center for Sustainability and the Global Environment (SAGE) of the University of Wisconsin at Madison, USA (http://www.geog.mcgill.ca/~nramankutty/ Datasets/Datasets.html and http://geomatics.geog.mcgill.ca/~navin/pub/Data/175crops2000/). The consistency between the grid product and the input data was quantified. MGAG-I and CC-I are fully consistent to each other on entity level. For input data other than CC-I, the consistency of MGAG-I on cell level was calculated. The consistency of MGAG-I with respect to the area equipped for irrigation (AEI) of GMIA and to the cropland extent of SAGE was characterised by the sum of the cell-specific maximum difference between the MGAG-I monthly total irrigated area and the reference area when the latter was exceeded in the grid cell. The consistency of the harvested area contained in MGAG-I with respect to SAGE harvested area was characterised by the crop-specific sum of the cell-specific difference between MGAG-I harvested area and the SAGE harvested area when the latter was exceeded in the grid cell. In all three cases, the sums are the excess areas that should not have been distributed under the assumption that the input data were correct. Globally, this cell-level excess of MGAG-I as compared to AEI is 331,304 ha or only about 0.12 % of the global AEI of 278.9 Mha found in the original grid. The respective cell-level excess of MGAG-I as compared to the SAGE cropland extent is 32.2 Mha, corresponding to about 2.2 % of the total cropland area. The respective cell-level excess of MGAG-I as compared to the SAGE harvested area is 27 % of the irrigated harvested area, or 11.5 % of the AEI. In a further step that will be published later also rainfed areas were compiled in order to form the Global data set of monthly irrigated and rainfed crop areas around the year 2000 (MIRCA2000). The data set can be used for global and continental-scale studies on food security and water use. In the future, it will be improved, e.g. with a better spatial resolution of crop calendars and an improved crop distribution algorithm. The MIRCA2000 data set, its full documentation together with future updates will be freely available through the following long-term internet site: http://www.geo.uni-frankfurt.de/ipg/ag/dl/forschung/MIRCA/index.html. The research presented here was funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) within the framework of the research project entitled "Consistent assessment of global green, blue and virtual water fluxes in the context of food production: regional stresses and worldwide teleconnections". The authors thank Navin Ramankutty and Chad Monfreda for making available the current SAGE datasets on cropland extent (Ramankutty et al., 2008) and harvested area (Monfreda et al., 2008) prior to their publication.
The introduction of a common currency as well as the harmonization of rules and regulations in Europe has significantly reduced distance in all its guises. With reduced costs of overcoming space, this emphasizes centripetal forces and it should foster consolidation of financial activity. In a national context, as a rule, this led to the emergence of one financial center. Hence, Europeanization of financial and monetary affairs could foretell the relegation of some European financial hubs such as Frankfurt and Paris to third-rank status. Frankfurt’s financial history is interesting insofar as it has lost (in the 1870s) and regained (mainly in the 1980s) its preeminent place in the German context. Because Europe is still characterized by local pockets of information-sensitive assets as well as a demand for variety the national analogy probably does not hold. There is room in Europe for a number of financial hubs of an international dimension, including Frankfurt.
Im Januar 2008 gab es von der FDP-Fraktion im Deutschen Bundestag eine kleine Anfrage an die Bundesregierung in der Absicht, das Grundgesetz zu ändern, um Privatschulen besser fördern zu können. In Art.7, Abs.4 heißt es, dass private Schulen „als Ersatz für öffentliche Schulen” „der Genehmigung des Staates” bedürfen und den Landesgesetzen unterstehen. Die Genehmigung ist zu erteilen, „wenn die privaten Schulen in ihren Lehrzielen und Einrichtungen sowie in der wissenschaftlichen Ausbildung ihrer Lehrkräfte nicht hinter den öffentlichen Schulen zurückstehen und eine Sonderung der Schüler nach den Besitzverhältnissen der Eltern nicht gefördert wird”. In ihrer Antwort auf die FDP-Anfrage sieht die Bundesregierung keine Notwendigkeit, das Grundgesetz zu ändern und verweist auf einen Beschluss des Bundesverfassungsgerichts aus dem Jahr 1992. In ihm wird bestätigt, dass der Staat dafür sorgen solle, dass Kinder verschiedener sozialer Schichten nicht durch Schulen getrennt werden. Privatschulen dürften deshalb nur eingerichtet werden, wenn spezielle pädagogische Konzepte oder religiöse Gründe vorlägen, die nicht durch eine öffentliche Schule abgedeckt würden. Das Gericht habe sich damals besorgt gezeigt, dass Privatschulen Kindern durch eine zu homogene Schülerschaft ein einseitiges Bild von der Gesellschaft vermitteln könnten. Die Bundesregierung ihrerseits befürchtet, dass Bundesländer noch unterschiedlicher über die Einrichtung von „freien Ersatzschulen” entscheiden würden als bisher schon, sollte der entsprechende Absatz im Grundgesetz gestrichen werden. (http://bildungsklick.de/pm/58086/regierung-gegen-grundgesetzaenderung) ...
In this paper we consider the dynamics of spot and futures prices in the presence of arbitrage. We propose a partially linear error correction model where the adjustment coefficient is allowed to depend non-linearly on the lagged price difference. We estimate our model using data on the DAX index and the DAX futures contract. We find that the adjustment is indeed nonlinear. The linear alternative is rejected. The speed of price adjustment is increasing almost monotonically with the magnitude of the price difference.
This study develops a novel 2-step hedonic approach, which is used to construct a price index for German paintings. This approach enables the researcher to use every single auction record, instead of only those auction records that belong to a sub-sample of selected artists. This results in a substantially larger sample available for research and it lowers the selection bias that is inherent in the traditional hedonic and repeat sales methodologies. Using a unique sample of 61,135 auction records for German artworks created by 5,115 different artists over the period 1985 to 2007, we find that the geometric annual return on German art is just 3.8 percent, with a standard deviation of 17.87 percent. Although our results indicate that art underperforms the market portfolio and is not proportionally rewarded for downside risk, under some circumstances art should be included in an optimal portfolio for diversification purposes.
While companies have emerged as very proactive donors in the wake of recent major disasters like Hurricane Katrina, it remains unclear whether that corporate generosity generates benefits to firms themselves. The literature on strategic philanthropy suggests that such philanthropic behavior may be valuable because it can generate direct and indirect benefits to the firm, yet it is not known whether investors interpret donations in this way. We develop hypotheses linking the strategic character of donations to positive abnormal returns. Using event study methodology, we investigate stock market reactions to corporate donation announcements by 108 US firms made in response to Hurricane Katrina. We then use regression analysis to examine if our hypothesized predictors are associated with positive abnormal returns. Our results show that overall, corporate donations were linked to neither positive nor negative abnormal returns. We do, however, see that a number of factors moderate the relationship between donation announcements and abnormal stock returns. Implications for theory and practice are discussed.
We estimate the degree of 'stickiness' in aggregate consumption growth (sometimes interpreted as reflecting consumption habits) for thirteen advanced economies. We find that, after controlling for measurement error, consumption growth has a high degree of autocorrelation, with a stickiness parameter of about 0.7 on average across countries. The sticky-consumption-growth model outperforms the random walk model of Hall (1978), and typically fits the data better than the popular Campbell and Mankiw (1989) model. In several countries, the sticky-consumption-growth and Campbell-Mankiw models work about equally well.
From sea to land and beyond : new insights into the evolution of euthyneuran Gastropoda (Mollusca)
(2008)
Background The Euthyneura are considered to be the most successful and diverse group of Gastropoda. Phylogenetically, they are riven with controversy. Previous morphology-based phylogenetic studies have been greatly hampered by rampant parallelism in morphological characters or by incomplete taxon sampling. Based on sequences of nuclear 18S rRNA and 28S rRNA as well as mitochondrial 16S rRNA and COI DNA from 56 taxa, we reconstructed the phylogeny of Euthyneura utilising Maximum Likelihood and Bayesian inference methods. The evolution of colonization of freshwater and terrestrial habitats by pulmonate Euthyneura, considered crucial in the evolution of this group of Gastropoda, is reconstructed with Bayesian approaches. Results We found several well supported clades within Euthyneura, however, we could not confirm the traditional classification, since Pulmonata are paraphyletic and Opistobranchia are either polyphyletic or paraphyletic with several clades clearly distinguishable. Sacoglossa appear separately from the rest of the Opisthobranchia as sister taxon to basal Pulmonata. Within Pulmonata, Basommatophora are paraphyletic and Hygrophila and Eupulmonata form monophyletic clades. Pyramidelloidea are placed within Euthyneura rendering the Euthyneura paraphyletic. Conclusion Based on the current phylogeny, it can be proposed for the first time that invasion of freshwater by Pulmonata is a unique evolutionary event and has taken place directly from the marine environment via an aquatic pathway. The origin of colonisation of terrestrial habitats is seeded in marginal zones and has probably occurred via estuaries or semi-terrestrial habitats such as mangroves.
Poster presentation In pharmaceutical research and drug development, machine learning methods play an important role in virtual screening and ADME/Tox prediction. For the application of such methods, a formal measure of similarity between molecules is essential. Such a measure, in turn, depends on the underlying molecular representation. Input samples have traditionally been modeled as vectors. Consequently, molecules are represented to machine learning algorithms in a vectorized form using molecular descriptors. While this approach is straightforward, it has its shortcomings. Amongst others, the interpretation of the learned model can be difficult, e.g. when using fingerprints or hashing. Structured representations of the input constitute an alternative to vector based representations, a trend in machine learning over the last years. For molecules, there is a rich choice of such representations. Popular examples include the molecular graph, molecular shape and the electrostatic field. We have developed a molecular similarity measure defined directly on the (annotated) molecular graph, a long-standing established topological model for molecules. It is based on the concepts of optimal atom assignments and iterative graph similarity. In the latter, two atoms are considered similar if their neighbors are similar. This recursive definition leads to a non-linear system of equations. We show how to iteratively solve these equations and give bounds on the computational complexity of the procedure. Advantages of our similarity measure include interpretability (atoms of two molecules are assigned to each other, each pair with a score expressing local similarity; this can be visualized to show similar regions of two molecules and the degree of their similarity) and the possibility to introduce knowledge about the target where available. We retrospectively tested our similarity measure using support vector machines for virtual screening on several pharmaceutical and toxicological datasets, with encouraging results. Prospective studies are under way.
Background The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This trial revealed residue mutations that confer varying degrees of drug resistance. In particular, two protease positions with the mutations V36A/G/L/M and T54A/S were associated with low to medium levels of drug resistance during viral breakthrough, together with only an intermediate reduction of viral replication fitness. These mutations are located in the protein interior and far away from the ligand binding pocket. Results Based on the available experimental structures of NS3-4A, we analyze the binding mode of different ligands. We also investigate the binding mode of VX-950 by protein-ligand docking. A network of non-covalent interactions between amino acids of the protease structure and the interacting ligands is analyzed to discover possible mechanisms of drug resistance. We describe the potential impact of V36 and T54 mutants on the side chain and backbone conformations and on the non-covalent residue interactions. We propose possible explanations for their effects on the antiviral efficacy of drugs and viral fitness. Molecular dynamics simulations of T54A/S mutants and rotamer analysis of V36A/G/L/M side chains support our interpretations. Experimental data using an HCV V36G replicon assay corroborate our findings. Conclusion T54 mutants are expected to interfere with the catalytic triad and with the ligand binding site of the protease. Thus, the T54 mutants are assumed to affect the viral replication efficacy to a larger degree than V36 mutants. Mutations at V36 and/or T54 result in impaired interaction of the protease residues with the VX-950 cyclopropyl group, which explains the development of viral breakthrough variants.
Wassergefiltertes Infrarot A (wIRA) ist eine spezielle Form der Wärmestrahlung. wIRA entspricht dem Großteil der in gemäßigten Klimazonen die Erdoberfläche wasserdampfgefiltert erreichenden Sonnenwärmestrahlung. wIRA vermag sowohl bei akuten Wunden als auch bei chronischen Wunden einschließlich infizierter Wunden Schmerzen deutlich zu mindern und eine erhöhte Wundsekretion und Entzündung herabzusetzen sowie positive immunmodulierende Effekte zu zeigen. wIRA kann die Wundheilung beschleunigen oder bei stagnierender Wundheilung verbessern oder sogar ermöglichen. Temperatur, Sauerstoffpartialdruck und Durchblutung im Gewebe als drei energetisch für Wundheilung wichtige Faktoren steigen. Selbst der normale Wundheilungsprozess kann durch wIRA verbessert werden. Die genannten Wirkungen sind durch sechs prospektive Studien belegt. Drei Studien wurden bei akuten Wunden durchgeführt: randomisierte, kontrollierte, doppeltblinde Studien der chirurgischen Universitätsklinik Heidelberg bei frischen abdominalen Operationswunden mit 111 Patienten und der Kinderchirurgie Kassel bei 45 schwerbrandverletzten Kindern sowie der Dermatologie der Charité Berlin bei 12 Probanden mit experimentellen Wunden. Drei Studien betreffen chronische venöse Unterschenkel-Ulzera: randomisierte, kontrollierte Studie in Basel mit 40 Patienten sowie prospektive Studie der Universität Tromsø/Norwegen und des Krankenhauses in Hillerød/Dänemark mit 10 Patienten mit u.a. aufwändiger Verlaufskontrolle mit Thermographie und derzeit durchgeführte randomisierte, kontrollierte, verblindete Studie der Universitätshautklinik Freiburg mit einem geplanten Umfang von ca. 50 Patienten.