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Zürich, 22. März 1937 - im ersten Stock des renommierten Herrenausstatters "London House" probiert Thomas Mann gerade einen neuen Anzug an, als ihn ein Verkäufer informiert, dass im Erdgeschoss Gerhart Hauptmann eingetroffen sei. "Möchten Sie ihn sehen?" Nach kurzem Zögern lehnt Thomas Mann ab - mit den Worten: "Ach, da wollen wir vielleicht doch andere Zeiten abwarten." Replik des Verkäufers: "Genau das hat Herr Hauptmann auch gesagt." Die Zürcher Nicht-Begegnung der beiden Nobelpreisträger ist in verschiedener Hinsicht bemerkenswert. Schließlich handelte es sich nicht nur um die international bekanntesten deutschen Schriftsteller, sondern auch um alte Bekannte. Und jeder von beiden hatte dem anderen manches zu verdanken. Warum also wollten die beiden einander nicht begegnen?
Um die literaturgeschichtliche Bedeutung der Situation im Zürcher Herrengeschäft einschätzen zu können, muss man die gesamte Beziehung zwischen beiden in den Blick fassen. Sie könnte wechselvoller kaum sein. Nach dreißig Jahren kollegialer, phasenweise nahezu freundschaftlicher Verbundenheit brach der Kontakt abrupt ab und wurde bis zu Hauptmanns Tod 1946 nicht mehr aufgenommen. Nach dem Ableben des älteren Kollegen ändert sich Thomas Manns Sicht auf Gerhart Hauptmann jedoch wieder. Und – soviel vorweg – dabei spielten Jubiläumsgeburtstage stets eine wichtige Rolle. Ich gehe zunächst auf die Phase der engen Bekanntschaft ein; im zweiten Teil dann auf die Umstände des Abbruchs der Beziehungen. Dabei soll vor allem der letzte Kontaktversuch genauer analysiert werden. Ein resümierender Blick auf die dritte Phase steht am Ende dieser Überlegungen. ...
Zukunftsmarkt Wasser nachhaltig gestalten ++ Dokumentation zur ISOE-Tagung „wahrhaft nützlich“ online ++ Klima wan del und Biodiversität – Folgen für Deutschland: Das Buch zum Stand der Forschung ist Umweltbuch des Monats ++ Wie gelingt erfolgreiche Umsetzungsforschung? ++ Sahel: Männer und Frauen vom Klimawandel unterschiedlich betroffen ++ ISOE-Lieferant Querbeet gewinnt Förderpreis für Öko-Landbau ++ Termine ++ Publikationen
BACKGROUND: Current biodiversity patterns are considered largely the result of past climatic and tectonic changes. In an integrative approach, we combine taxonomic and phylogenetic hypotheses to analyze temporal and geographic diversification of epigean (Carychium) and subterranean (Zospeum) evolutionary lineages in Carychiidae (Eupulmonata, Ellobioidea). We explicitly test three hypotheses: 1) morphospecies encompass unrecognized evolutionary lineages, 2) limited dispersal results in a close genetic relationship of geographical proximally distributed taxa and 3) major climatic and tectonic events had an impact on lineage diversification within Carychiidae.
RESULTS: Initial morphospecies assignments were investigated by different molecular delimitation approaches (threshold, ABGD, GMYC and SP). Despite a conservative delimitation strategy, carychiid morphospecies comprise a great number of unrecognized evolutionary lineages. We attribute this phenomenon to historic underestimation of morphological stasis and phenotypic variability amongst lineages. The first molecular phylogenetic hypothesis for the Carychiidae (based on COI, 16S and H3) reveals Carychium and Zospeum to be reciprocally monophyletic. Geographical proximally distributed lineages are often closely related. The temporal diversification of Carychiidae is best described by a constant rate model of diversification. The evolution of Carychiidae is characterized by relatively few (long distance) colonization events. We find support for an Asian origin of Carychium. Zospeum may have arrived in Europe before extant members of Carychium. Distantly related Carychium clades inhabit a wide spectrum of the available bioclimatic niche and demonstrate considerable niche overlap.
CONCLUSIONS: Carychiid taxonomy is in dire need of revision. An inferred wide distribution and variable phenotype suggest underestimated diversity in Zospeum. Several Carychium morphospecies are results of past taxonomic lumping. By collecting populations at their type locality, molecular investigations are able to link historic morphospecies assignments to their respective evolutionary lineage. We propose that rare founder populations initially colonized a continent or cave system. Subsequent passive dispersal into adjacent areas led to in situ pan-continental or mountain range diversifications. Major environmental changes did not influence carychiid diversification. However, certain molecular delimitation methods indicated a recent decrease in diversification rate. We attribute this decrease to protracted speciation.
Background: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell responses, resulting in a survival benefit of the tumor. For colorectal cancer (CRC) the clinical relevance of Foxp3 has not been evaluated in detail. Therefore the aim of this study was to study its impact in colorectal cancer (CRC).
Methods and Findings: Gene and protein analysis of tumor tissues from patients with CRC was performed to quantify the expression of Foxp3 in tumor infiltrating Treg and colon cancer cells. The results were correlated with clinicopathological parameters and patients overall survival. Serial morphological analysis demonstrated Foxp3 to be expressed in cancer cells. High Foxp3 expression of the cancer cells was associated with poor prognosis compared to patients with low Foxp3 expression. In contrast, low and high Foxp3 level in tumor infiltrating Treg cells demonstrated no significant differences in overall patient survival.
Conclusions: Our findings strongly suggest that Foxp3 expression mediated by cancer cells rather than by Treg cells contribute to disease progression.
Ribosome biogenesis is well described in Saccharomyces cerevisiae. In contrast only very little information is available on this pathway in plants. This study presents the characterization of five putative protein co-factors of ribosome biogenesis in Arabidopsis thaliana, namely Rrp5, Pwp2, Nob1, Enp1 and Noc4. The characterization of the proteins in respect to localization, enzymatic activity and association with pre-ribosomal complexes is shown. Additionally, analyses of T-DNA insertion mutants aimed to reveal an involvement of the plant co-factors in ribosome biogenesis. The investigated proteins localize mainly to the nucleolus or the nucleus, and atEnp1 and atNob1 co-migrate with 40S pre-ribosomal complexes. The analysis of T-DNA insertion lines revealed that all proteins are essential in Arabidopsis thaliana and mutant plants show alterations of rRNA intermediate abundance already in the heterozygous state. The most significant alteration was observed in the NOB1 T-DNA insertion line where the P-A3 fragment, a 23S-like rRNA precursor, accumulated. The transmission of the T-DNA through the male and female gametophyte was strongly inhibited indicating a high importance of ribosome co-factor genes in the haploid stages of plant development. Additionally impaired embryogenesis was observed in some mutant plant lines. All results support an involvement of the analyzed proteins in ribosome biogenesis but differences in rRNA processing, gametophyte and embryo development suggested an alternative regulation in plants.
Background: Group-based social skills training (SST) has repeatedly been recommended as treatment of choice in high-functioning autism spectrum disorder (HFASD). To date, no sufficiently powered randomised controlled trial has been performed to establish efficacy and safety of SST in children and adolescents with HFASD. In this randomised, multi-centre, controlled trial with 220 children and adolescents with HFASD it is hypothesized, that add-on group-based SST using the 12 weeks manualised SOSTA–FRA program will result in improved social responsiveness (measured by the parent rated social responsiveness scale, SRS) compared to treatment as usual (TAU). It is further expected, that parent and self reported anxiety and depressive symptoms will decline and pro-social behaviour will increase in the treatment group. A neurophysiological study in the Frankfurt HFASD subgroup will be performed pre- and post treatment to assess changes in neural function induced by SST versus TAU.
Methods/design: The SOSTA – net trial is designed as a prospective, randomised, multi-centre, controlled trial with two parallel groups. The primary outcome is change in SRS score directly after the intervention and at 3 months follow-up. Several secondary outcome measures are also obtained. The target sample consists of 220 individuals with ASD, included at the six study centres.
Discussion: This study is currently one of the largest trials on SST in children and adolescents with HFASD worldwide. Compared to recent randomised controlled studies, our study shows several advantages with regard to in- and exclusion criteria, study methods, and the therapeutic approach chosen, which can be easily implemented in non-university-based clinical settings.
Trial registration: ISRCTN94863788 – SOSTA – net: Group-based social skills training in children and adolescents with high functioning autism spectrum disorder.
Bis vor kurzem definierte das Grundgesetz die Grundstrukturen des öffentlichen Rechts in Deutschland, sei es im Bund, sei es in den Ländern. Heute wirken jedoch supranationale und internationale Institutionen machtvoll auf das soziale Zusammenleben in Deutschland ein. Zudem besteht eine neue Offenheit gegenüber Hoheitsakten anderer Staaten. Diese Europäisierung und Internationalisierung des Landes führen zur Frage, wie nunmehr die Grundstrukturen des öffentlichen Rechts in Deutschland begriffen werden sollen.
Diese Grundstrukturen sind Gegenstand dieses Beitrags, und zwar im Sinne von Grundprinzipien, welche alle in Deutschland wirksame öffentliche Gewalt einbinden. Der Beitrag kann dabei, entsprechend dem Stand der Erkenntnis, nur wenig gesichertes Wissen unterbreiten. Eine systematische, praxisleitende und vor allem prinzipiengesteuerte Dogmatik eines Rechts der Menschheit, eines kosmopolitischen Rechts, eines globalen Rechts, eines Weltrechts, eines Weltinnenrechts, eines transnationalen Rechts, ja selbst des Völkerrechts oder auch nur des öffentlichen Rechts im europäischen Rechtsraums, also etwas in Ansätzen dem deutschen Staatsrecht Vergleichbares, erscheint jenseits der Möglichkeiten, jedenfalls des Horizonts unserer Zeit. Vor diesem Hintergrund unterbreitet dieser Beitrag sein Verständnis des neuen Forschungsfeldes (I.), verankert die relevanten Prinzipien positivrechtlich und skizziert sie in ihrem Gestaltungsanspruch (II.), und erörtert ihr gegenseitiges Verhältnis, um dadurch die Gesamtkonstellation zu beleuchten (III.).