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En passant par Francfort, sa ville natale, le 23 août 1797, Goethe fait la découverte d'"environ deux cents gravures satiriques françaises" comme il l'écrit le lendemain à Schiller. Il s'agit de gravures faites il y a deux ou trois ans à Paris, la dernière au mois de mars 1797. [...] De toute façon Goethe choisit 55 de ces gravures, les "schématise" (ibid.), comme il dit lui-même, et en donne une brève description. Résultat: le manuscrit "Recension einer Anzahl französischer satyrischer Kupferstiche" que son secrétaire du nom de Geist recopie sous la dictée de son maître.
Aims: Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele frequency (VAF) ≥ 2% have been associated with atherosclerosis and chronic heart failure of ischemic origin (CHF). However, the effects of mutations in other driver genes for CH with low VAF (<2%) on CHF are still unknown.
Methods and results: Therefore, we analysed mononuclear bone marrow and blood cells from 399 CHF patients by deep error-corrected targeted sequencing of 56 genes and associated mutations with the long-term mortality in these patients (3.95 years median follow-up). We detected 1113 mutations with a VAF ≥ 0.5% in 347 of 399 patients, and only 13% had no detectable CH. Despite a high prevalence of mutations in the most frequently mutated genes DNMT3A (165 patients) and TET2 (107 patients), mutations in CBL, CEBPA, EZH2, GNB1, PHF6, SMC1A, and SRSF2 were associated with increased death compared with the average death rate of all patients. To avoid confounding effects, we excluded patients with DNMT3A-related, TET2-related, and other clonal haematopoiesis of indeterminate potential (CHIP)-related mutations with a VAF ≥ 2% for further analyses. Kaplan–Meier survival analyses revealed a significantly higher mortality in patients with mutations in either of the seven genes (53 patients), combined as the CH-risk gene set for CHF. Baseline patient characteristics showed no significant differences in any parameter including patient age, confounding diseases, severity of CHF, or blood cell parameters except for a reduced number of platelets in patients with mutations in the risk gene set in comparison with patients without. However, carrying a mutation in any of the risk genes remained significant after multivariate cox regression analysis (hazard ratio, 3.1; 95% confidence interval, 1.8–5.4; P < 0.001), whereas platelet numbers did not.
Conclusions: Somatic mutations with low VAF in a distinct set of genes, namely, in CBL, CEBPA, EZH2, GNB1, PHF6, SMC1A, and SRSF2, are significantly associated with mortality in CHF, independently of the most prevalent CHIP-mutations in DNMT3A and TET2. Mutations in these genes are prevalent in young CHF patients and comprise an independent risk factor for the outcome of CHF, potentially providing a novel tool for risk assessment in CHF.
Electric stimulation of the auditory nerve via cochlear implants has made the treatment of sensory deafness possible. Advanced signal processing and stimulation paradigms have led to continuously improved results in speech understanding. Consequently, indication criteria have been extended to patients with profound and severe-to-profound hearing loss and limited speech understanding with conventional acoustic amplification.
Outside this group, a considerable number of patients presents with rather wellpreserved, low frequency hearing of 30-60 dB up to 1 kHz, but severe loss in the mid to high frequency range of more than 60-70 dB. Monosyllabic word scores in these patients do not generally exceed 35%, due to missing consonant information. But, even increasing the audibility of these high frequencies by acoustic amplification still has very limited efficiency for discriminating speech, and therefore, these patients obtain only minor benefit from conventional hearing aids. On the other hand, standard cochlear implantation would carry a high risk of causing complete hearing loss. This situation has led to considering a combination of both modes of stimulation for these patients who are on the borderline between hearing aids and cochlear implant.
In our present model, the surviving low frequency region of the cochlea could still be stimulated acoustically-combined with additional electrical stimulation of the impaired mid and high frequency region of the cochlea.
Several questions still have to be answered with regard to combined electric and acoustic stimulation (EAS). The possible interaction of electric and acoustic stimuli on the different levels off the auditory system is a major issue. Animal experiments clearly demonstrate that tuning properties of auditory neurons, in response to acute acoustic stimulation, are essentially preserved in the presence of electric stimulation even at high levels of electric stimulation, and that chronic electric stimulation of tie intact inner ear does not have a significant effect on the compound action potentials (CAP) thresholds or inner ear function.
In a previous report, we were able to show that this combined F.A.S of the auditory system is possible in humans, and that it has a synergistic effect on speech understanding. Further major issues regard the surgical feasibility and reproducibility of cochlear implantation with the preservation of residual hearing.
Encouraged by our findings, a clinical study was initiated on the application of EAS. So far, seven adults have been included in this study. In addition, one child has been implanted outside the study.
Es mag sein, dass sich die japanische Kultur – ganz abgesehen von der Schrift – nicht leicht lesen lässt. Aber warum denn nicht? Warum soll uns die reizvolle Erfahrung erspart bleiben, dass ein wirtschaftlich und technologisch ebenbürtiger Partner der Weltgesellschaft sein Niveau auf einem andern Weg, aufgrund einer verschiedenen sozialen Kultur erreicht hat? Dass sich vermeintliche Universalien – Natur, Liebe, Religion, Familie, Individualität, Bindung, Freiheit – auch ganz anders buchstabieren und in stark abweichender Besetzung bis in 21. Jahrhundert mit Erfolg halten lassen? Warum eigentlich sollen wir nicht besser lesen lernen?
Schon im Jahr 1970 rechnet der noch junge und von Film und Rockmusik gleichermaßen begeisterte Wim Wenders mit einem Genre ab, "das es nicht gibt": mit dem Musikfilm, vor allem mit den "Rock'n'Roll- und Popmusikfilmen" (Wenders 1989, 82), die bis dato entstanden und denen er insgesamt vorwirft, gerade an der Darstellung der Musik zu scheitern. "Sie zeigen mehr ihr Desinteresse, ihr Missfallen oder ihre Verachtung als ihren Gegenstand. Das, was es zu sehen gibt, die Musiker, die Instrumente, die Bühne, die Arbeit, der Spaß oder die Anstrengung, Musik zu machen, erscheint ihnen nicht wert genug, so wie es ist, gezeigt zu werden" (83). Wenders wirft den Musikfilmen vor, nicht dem authentischen Entstehen der Musik im Augenblick, also live auf der Bühne, und nicht dem Ausdruck der Musik gerecht werden, sondern die eigene Sprache der Rockmusik in eine andere, in die des Films zu übertragen.
Ihrem letzten Roman "In Amerika" (2000) stellte Susan Sontag als Motto eine Zeile des afroamerikanischen Poeten Langston Hughes voran: "America will be!" Der Lockruf eines Landes, das permanent im Entstehen ist, das wird, um einmal zu existieren, vielleicht nur als schöner Traum, bestimmt diesen historischen Roman, in dem eine polnische Schauspielerin, eine Diva, im Jahr 1876 ihre Heimat verlässt, um ihm zu folgen und dann doch nie sesshaft zu werden in Amerika. Die "Sehnsucht nach Neuem, Leerem, Vergangenheitslosem", und der "Traum, das Leben in reine Zukunft zu verwandeln" in der neuen Welt, treiben sie stets weiter, von Stadt zu Stadt, von einer Rolle zur nächsten. Die Schauspielerin bringt Kultur in ein raues Land, indem sie Kunst lebt, auf einer "lange(n) Tournee", wie die letzen Worte des Romans verheißen.
Liest man die heute schon reichlich nostalgisch angehauchten Rückblicke auf die Blütezeit des Neuen deutschen Films in den siebziger Jahren, dann stößt man auf die Namen Fassbinder, Schlöndorff, Wenders und Herzog, vielleicht noch Kluge und Schroeter. Kaum aber noch fällt der Name Hans Jürgen Syberberg. Das ist um so erstaunlicher, da Syberberg damals im Ausland – und wo sonst, wenn nicht im Ausland, galt der Neue deutsche Film als das, was er in der Bundesrepublik nie war: als kulturelle Dominante – als der deutsche Filmemacher schlechthin angesehen wurde.
Die Sackspinne Clubiona similis L. Koch, 1867 wird in der älteren Literatur aus den verschiedensten Gebieten und Lebensraumtypen Mittel- und Osteuropas erwähnt. Nach HEIMER & NENTWIG (1991) ist sie "in feuchtem Gelände auf niedriger Vegetation" zu finden. Bei HANGGI et al. (1995) werden überwiegend Nachweise aus Küstendünen, daneben einzelne aus Wäldern und extensiv oder ungenutzten Lebensraumtypen des Offenlandes genannt.
The study objective was to assess the current status of HIV knowledge, attitudes and behavior (KAB) among employees of Namibian ministries. As most HIV campaigning takes place in the capital of Windhoek, an additional aim was to compare Windhoek to four regions (Hardap, Erongo, Oshana, and Caprivi). Between January and March 2011 a cross-sectional survey was conducted in two Namibian ministries, with participants selected randomly from the workforce. Data collection was based on questionnaires. 832 participants were included in the study (51.6% male). Nearly 90% of participants reported to have been tested for HIV before. Knowledge about HIV transmission ranged from 67% to 95% of correct answers, with few differences between the capital and regions. However, a knowledge gap regarding HIV transmission and prevention was seen. In particular, we found significantly lower knowledge regarding transmission from mother-to-child during pregnancy and higher rate of belief in a supernatural role in HIV transmission. In addition, despite many years of HIV prevention activities, a substantial proportion of employees had well-known HIV risk factors including multiple concurrent partnership rates (21%), intergenerational sex (19%), and lower testing rates for men (82% compared to women with 91%).
In this paper I intend to discuss the relation of Marcuse’s theory of technology to its grounding in the possibilities he believed lay inherent, but as yet untapped in nature. Marcuse was an early critic of what he considered to be the exploitative, predatory approach to nature brought about through the direction of technology, industry and science under consumer capitalism, however his alternative; a “new science” and “new technology” which would treat nature as an “ally” in the general struggle for liberation and emancipation, was not without its problems.
Combining cultural history with the insights of psychoanalytic theory, this article examines Maurice Sendak's Caldecott-winning and controversial Where the Wild Things Are (1963), arguing that Sendak’s book represents picturebook psychology as it stood in the early 1960s but also radically recasts it, paving the way for a groundswell in applied picturebook psychology. The book can be understood as rewriting classical Freudian analysis, retaining some of its rigor and edge while making it more palatably American. Where the Wild Things Are has been embraced as a psychological primer, a story about anger and its management through fantasy; it is also a text in which echoes of Freud remain audible. It is read it here as a bedtime-story version of Freud’s Wolf Man case history of 1918, an updated and upbeat dream of the wolf boy. It is to Sendak what the Wolf Man case was to Freud, a career-making feral tale. Standing at the crossroads of Freudian tradition, child analysis, humanistic psychology, and bibliotherapy, the article reveals how the book both clarified and expanded the uses of picturebook enchantment.
The widespread application of fertilizers has greatly influenced many processes and properties of agroecosystems, and agricultural fertilization is expected to increase even further in the future. To date, most research on fertilizer impacts has used short-term studies, which may be unrepresentative of long-term responses, thus hindering our capacity to predict long-term impacts. Here, we examined the effects of long-term fertilizer addition on key ecosystem properties in a long-term grassland experiment (Palace Leas Hay Meadow) in which farmyard manure (FYM) and inorganic fertilizer treatments have been applied consistently for 120 years in order to characterize the experimental site more fully and compare ecosystem responses with those observed at other long-term and short-term experiments. FYM inputs increased soil organic carbon (SOC) stocks, hay yield, nutrient availability and acted as a buffer against soil acidification (>pH 5). In contrast, N-containing inorganic fertilizers strongly acidified the soil (<pH 4.5) and increased surface SOC stocks by increasing the C stored in the coarse (2.8 mm-200 μm) and fine (200–50 μm) fractions. Application of N fertilizers also reduced plant species richness and the abundance of forbs and legumes. Overall, our results were broadly consistent with those observed in other very long-term studies (the Park Grass and Steinach Grassland experiments) in that fertilization effects on plant and soil properties appeared to be driven by differences in both nutrient input and changes to soil pH. We also established that the direction of long-term fertilization effects tended to be comparable with short-term experiments, but that their magnitude differed considerably, particularly where ammonium sulphate-induced acidification had occurred. We therefore conclude that short-term studies are unlikely to possess the required timeframe to accurately predict long-term responses, thus necessitating the use of long-term study sites. Such experiments should be strategically established in regions where future fertilizer use is expected to increase rapidly.
This book makes an important contribution to existing knowledge on the processes of reading and comprehension by identifying the various approaches and corresponding theories. The book is organized in various chapters that cumulatively lead to our entry into the three key areas. Chapter One provides important background to reading as a skill, explaining the hidden dynamics that avoid the process and outcome of reading. Chapter Two deals with comprehension and vocabulary, both very important aspects of the reading process, while Chapter Three focuses on the relationship between reading, remembering and perception. Chapters four and five deal with various ways of assessing comprehension and the role of the reader respectively.
The Devil's Hill
(2012)
Dani is gifted in all ways, yet he lives under the shadow of his hero, an old friend and a school dropout. The day he discovers a heap of money and a gun under a trap door in his friend's house, he realised his friend was no longer a mere bully but a member of a dangerous gang wanted for various crimes ranging from smuggling diamonds, carjacking to murder. This becomes the beginning of a nightmare that nearly costs Dani his life as well as that of another of his friends, Zack.
Edukative Grenzüberschreitung : Text-Bild-Verweise in 'The League of Extraordinary Gentlemen'
(2017)
Zwar integrieren Comics bildliche und textuale Elemente. Oft herrscht in einzelnen Bildern oder Szenen aber ein Primat des Texts oder des Bildes vor. Dies bedeutet eine faktische Text-Bild-Trennung im Comic-Panel. 'The League of Extraordinary Gentlemen' macht diese Text-Bild-Grenzen durch gezielte Überschreitungen fruchtbar: Die implizite Hierarchie von Text und Bild wird durch gegenseitige, explizite Verweise aufeinander in Frage gestellt. Dies lässt auch den Informationswert der einzelnen Panels zweifelhaft erscheinen: Geht hier mehr vor sich, als auf den ersten Blick ersichtlich ist? 'League' provoziert so ein aufmerksames, 'detektivisches Lesen', das sensibel ist gegen die Verweisstrukturen des Comics. Dieser zeigt über sich selbst – auf einen Kanon literarischer Vorlagen – hinaus.
In natural environments, background noise can degrade the integrity of acoustic signals, posing a problem for animals that rely on their vocalizations for communication and navigation. A simple behavioral strategy to combat acoustic interference would be to restrict call emissions to periods of low-amplitude or no noise. Using audio playback and computational tools for the automated detection of over 2.5 million vocalizations from groups of freely vocalizing bats, we show that bats (Carollia perspicillata) can dynamically adapt the timing of their calls to avoid acoustic jamming in both predictably and unpredictably patterned noise. This study demonstrates that bats spontaneously seek out temporal windows of opportunity for vocalizing in acoustically crowded environments, providing a mechanism for efficient echolocation and communication in cluttered acoustic landscapes.
One Sentence Summary: Bats avoid acoustic interference by rapidly adjusting the timing of vocalizations to the temporal pattern of varying noise.
In natural environments, background noise can degrade the integrity of acoustic signals, posing a problem for animals that rely on their vocalizations for communication and navigation. A simple behavioral strategy to combat acoustic interference would be to restrict call emissions to periods of low-amplitude or no noise. Using audio playback and computational tools for the automated detection of over 2.5 million vocalizations from groups of freely vocalizing bats, we show that bats (Carollia perspicillata) can dynamically adapt the timing of their calls to avoid acoustic jamming in both predictably and unpredictably patterned noise. This study demonstrates that bats spontaneously seek out temporal windows of opportunity for vocalizing in acoustically crowded environments, providing a mechanism for efficient echolocation and communication in cluttered acoustic landscapes.
One Sentence Summary Bats avoid acoustic interference by rapidly adjusting the timing of vocalizations to the temporal pattern of varying noise.