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Religion sei "das Opium des Volks", das einem herz- und geistlosen "Jammertal" einen Heiligenschein verleihe. Der werde verschwinden, wenn "die Kritik des Jammertals" zur "Wahrheit des Diesseits" geführt habe, so Karl Marx 1844. Und heute: Die Religion existiert weiter, eine "wahre" Gesellschaft ist nicht verwirklicht. Im Gespräch mit vier Frankfurter Professoren erkundet der Philosoph und Publizist Rolf Wiggershaus, wie Religionsexperten das aktuelle Verhältnis von Religion und Gesellschaft sehen.
"Toleranz kommt vor Glückseligkeit" : eine Zeitreise mit der Tugend des gegenseitigen Respekts
(2016)
Toleranz ist gerade da nötig, wo sie besonders schwerfällt. Das war schon vor gut 300 Jahren so, als Denker wie der französische Philosoph Pierre Bayle in Zeiten religiöser Auseinandersetzungen den Grundstein für ein fortschrittliches Toleranz-Verständnis legten. Warum der Begriff gerade heute wieder Konjunktur hat und wie umstritten er noch immer ist, erläutert der politische Philosoph Rainer Forst im Gespräch mit Bernd Frye.
Phenology is the study of periodic life cycle events of living organisms and how these are influenced by environmental factors. Late phenological phases such as the timing of seed release and subsequent seed dispersal considerably affect ecology and evolution in plants. Since plants are mostly sessile organisms, seed dispersal is a crucial life cycle event for the ecology and evolution of plants. In fact, long-distance seed dispersal (LDD) is a very complex process in plant biology and significantly shapes the spatial and temporal dynamics of plant populations. For example, wind dispersal in plants is influenced by a variety of factors such as plant traits, habitat type and environmental conditions (e.g. wind speed). Considering the variability of wind conditions throughout the year, the timing of seed release and dispersal is known to have considerable effects on LDD. Even though late phenologies such as ripening duration and timing of seed release and subsequent dispersal are vital in estimating ecologically highly relevant LDD, these phenologies are not appropriately addressed in ecological research. The aim of this thesis is to gain insights into the factors that shape late plant phenologies. In particular, we address the following questions: which ecologically or evolutionary parameters drive the ripening process of plant species? How does the seasonal variability of wind affect the seed release phenology of plant species? How do these factors interact for plant species in different habitat types?
In order to address these questions, we applied different methodological approaches, ranging from fieldwork and monitoring phenology to computational simulation studies and statistical modeling. To study the ripening process of species, we monitored the flowering, ripening and seed release phenology of more than 100 Central European plant species. We conducted computational simulation studies for estimating LDD by wind to study the phenology of seed release and the parameters determining LDD by wind. In conjunction with phenological data from literature, we used the obtained simulation results to investigate evidence for the existence of phenological adaptations towards LDD in 165 plant species. Further, we used the results from simulation studies of LDD by wind to disentangle the effects of species, habitat types and meteorological conditions and their interactions on the spatial spread of plant species.
The results of the relationship between plant traits, phylogeny, the ripening process and climatic factors provide insights into the basic understanding of the ripening process of plants. We identified ecological factors that shape species’ ripening phenology and seed release timing. In particular, we suggest that the species’ seed weight, life form and phylogeny shapes ripening and seed release phenology. With the statistical models on species’ temperature demands for reproduction, we introduce data that that are well suitable for parametrization and further development of plant dispersal models. The results from the simulation study based on a seasonal perspective showed that heavier seeded tree species with medium wind dispersal potential (including genera Abies, Acer, Fraxinus and Larix) have a clear synchronisation of seed abscission with periods favouring LDD. These species, which are both ecologically and economically important, showed significant synchronisation of the highest rate of seed release with high wind-speed that promoted LDD by wind in wintertime. For the tree species mentioned, we suggest strong seasonal synchronisation as evidence for phenological adaptations in order to match favourable conditions during seed release. With a closer look at the wind conditions that promote LDD by wind, our results showed considerable differences in how specific wind conditions affect LDD in different species and habitat types. We suggest that LDD by wind in species from open habitats with high wind dispersal potential is likely to be driven by thermal updrafts that are mainly driven by the sun providing energy to the ground. By contrast, LDD of heavier-seeded species from open and forested habitats is more likely to be driven by storms that produce shear-driven turbulence. The results from this thesis contribute to an increased understanding of the complete dispersal process of plants and to making more realistic projections of (future) plant distribution.
The results obtained on factors driving ripening and release phenology provide valuable insights into their ecological and phylogenetic factor constraints. The implementation of more realistic assumptions in assessing species’ dispersal potential throughout the year could help considerably in improving landscape management (e.g. timing of mowing) and in the conservation of plant populations. The evidence found for phenological adaptations towards LDD in plants is an important step in understanding the evolutionary basis of LDD in these species.
Telecommunications companies traditionally offer several tariffs from which their customers can choose the tariff that best suits their preferences. Yet, customers sometimes make choices that are not optimal for them because they do not minimize their bill for a certain usage amount. We show in this paper that companies should be very concerned about choices in which customers pick tariffs that are too small for them because they lead to a significant increase in customers churn. In contrast, this is not the case if customers choose tariffs that are too big for them. The reason is that in particular flat-rates provide customers with the additional benefit that they guarantee a constant bill amount that consumption can be enjoyed more freely because all costs are already accounted for.
Correlated activity of cortical neurons survives extensive removal of feedforward sensory input
(2016)
A fundamental property of brain function is that the spiking activity of cortical neurons is variable and that some of this variability is correlated between neurons. Correlated activity not due to the stimulus arises from shared input but the neuronal circuit mechanisms that result in these noise correlations are not fully understood. Here we tested in the visual system if correlated variability in mid-level area V4 of visual cortex is altered following extensive lesions of primary visual cortex (V1). To this end we recorded longitudinally the neuronal correlations in area V4 of two behaving macaque monkeys before and after a V1 lesion while the monkeys fixated a grey screen. We found that the correlations of neuronal activity survived the lesions in both monkeys. In one monkey, the correlation of multi-unit spiking signals was strongly increased in the first week post-lesion, while in the second monkey, correlated activity was slightly increased, but not greater than some week-by-week fluctuations observed. The typical drop-off of inter-neuronal correlations with cortical distance was preserved after the lesion. Therefore, as V4 noise correlations remain without feedforward input from V1, these results suggest instead that local and/or feedback input seem to be necessary for correlated activity.
Infections are an important cause for morbidity and mortality in pediatric acute myeloid leukemia (AML). We therefore characterized infectious complications in children treated according to the trial AML-BFM 2004. Patients with Down syndrome were excluded from the analysis. Data were gathered from the medical records in the hospital where the patients were treated. A total of 405 patients (203 girls; median age 8.4 years) experienced 1326 infections. Fever without identifiable source occurred in 56.1% of the patients and clinically and microbiologically documented infections in 17.5% and 32.4% of the patients, respectively. In all, 240 Gram-positive (112 viridans group streptococci) and 90 Gram-negative isolates were recovered from the bloodstream. Invasive fungal infection was diagnosed in 3% of the patients. Three children each died of Gram-negative bacteremia and invasive aspergillosis, respectively. As compared with the results of AML-BFM 93 with lower dose intensity, infection-related morbidity was slightly higher in AML-BFM 2004 (3.3. versus 2.8 infections per patient), whereas infection-related mortality significantly decreased (1.5% versus 5.4%; P=0.003). Specific anti-infective recommendations included in the treatment protocol, regular training courses for pediatric hematologists and increasing experience may be the reason for reduced infection-related mortality in children with AML. Further studies are needed to decrease infection-related morbidity.
A complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients with acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ in the definition of unbalanced aberrations as well as the number of single aberrations. The aim of this study on 3526 AML patients was to redefine and validate a cutoff for karyotype complexity in AML with regard to adverse prognosis. Our study demonstrated that (1) patients with a pure hyperdiploid karyotype have an adverse risk irrespective of the number of chromosomal gains, (2) patients with translocation t(9;11)(p21~22;q23) have an intermediate risk independent of the number of additional aberrations, (3) patients with greater than or equal to4 abnormalities have an adverse risk per se and (4) patients with three aberrations in the absence of abnormalities of strong influence (hyperdiploid karyotype, t(9;11)(p21~22;q23), CBF-AML, unique adverse-risk aberrations) have borderline intermediate/adverse risk with a reduced overall survival compared with patients with a normal karyotype.
DNA methylation is a major regulatory process of gene transcription, and aberrant DNA methylation is associated with various diseases including cancer. Many compounds have been reported to modify DNA methylation states. Despite increasing interest in the clinical application of drugs with epigenetic effects, and the use of diagnostic markers for genome-wide hypomethylation in cancer, large-scale screening systems to measure the effects of drugs on DNA methylation are limited. In this study, we improved the previously established fluorescence polarization-based global DNA methylation assay so that it is more suitable for application to human genomic DNA. Our methyl-sensitive fluorescence polarization (MSFP) assay was highly repeatable (inter-assay coefficient of variation = 1.5%) and accurate (r2 = 0.99). According to signal linearity, only 50–80 ng human genomic DNA per reaction was necessary for the 384-well format. MSFP is a simple, rapid approach as all biochemical reactions and final detection can be performed in one well in a 384-well plate without purification steps in less than 3.5 hours. Furthermore, we demonstrated a significant correlation between MSFP and the LINE-1 pyrosequencing assay, a widely used global DNA methylation assay. MSFP can be applied for the pre-screening of compounds that influence global DNA methylation states and also for the diagnosis of certain types of cancer.
The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction leading to reduced energy supply, impaired neuroplasticity, and finally cell death as one major pathomechanism underlying the continuum from brain aging over mild cognitive impairment to initial and advanced late onset Alzheimer's disease. Accordingly, improving mitochondrial function has become an important strategy to treat the early stages of this continuum. The metabolic enhancer piracetam has been proposed as possible prototype for those compounds by increasing impaired mitochondrial function and related aspects like mechanisms of neuroplasticity. We here report that piracetam at therapeutically relevant concentrations improves neuritogenesis in the human cell line SH-SY5Y over conditions mirroring the whole spectrum of age-associated cognitive decline. These effects go parallel with improvement of impaired mitochondrial dynamics shifting back fission and fusion balance to the energetically more favorable fusion site. Impaired fission and fusion balance can also be induced by a reduction of the mitochondrial permeability transition pore (mPTP) function as atractyloside which indicates the mPTP has similar effects on mitochondrial dynamics. These changes are also reduced by piracetam. These findings suggest the mPTP as an important target for the beneficial effects of piracetam on mitochondrial function.
The general assumption that brain size differences are an adequate proxy for subtler differences in brain organization turned neurobiologists toward the question why some groups of mammals such as primates, elephants, and whales have such remarkably large brains. In this meta-analysis, an extensive sample of eutherian mammals (115 species distributed in 14 orders) provided data about several different biological traits and measures of brain size such as absolute brain mass (AB), relative brain mass (RB; quotient from AB and body mass), and encephalization quotient (EQ). These data were analyzed by established multivariate statistics without taking specific phylogenetic information into account. Species with high AB tend to (1) feed on protein-rich nutrition, (2) have a long lifespan, (3) delayed sexual maturity, and (4) long and rare pregnancies with small litter sizes. Animals with high RB usually have (1) a short life span, (2) reach sexual maturity early, and (3) have short and frequent gestations. Moreover, males of species with high RB also have few potential sexual partners. In contrast, animals with high EQs have (1) a high number of potential sexual partners, (2) delayed sexual maturity, and (3) rare gestations with small litter sizes. Based on these correlations, we conclude that Eutheria with either high AB or high EQ occupy positions at the top of the network of food chains (high trophic levels). Eutheria of low trophic levels can develop a high RB only if they have small body masses.
G protein coupled receptors (GPCRs) constitute the largest family of cell-surface receptors in mammals and are key players in signal transduction. By responding to a plethora of extracellular stimuli ranging from photons to amines to fatty acids to peptides and proteins, these receptors trigger intracellular signalling cascades and regulate a variety of cellular responses. Approximately 800 genes in humans encode GPCRs which are classified according to sequence conservation into rhodopsin-like, glutamate, adhesion, frizzled/taste2 and secretin receptors. GPCRs share a seven transmembrane domain fold undergoing a conformational change upon ligand binding which is translated to the intracellular surface of the receptor thereby allowing a heterotrimeric G protein to couple. Heterotrimeric G proteins consist of a Ga, Gb and Gg subunit and dissociate into their Ga and Gbg entities upon activation by a GPCR. Subsequently, distinct signalling cascades are triggered by each G protein protomer.
Membrane proteins and GPCRs in particular, are highly important targets in drug design and development as currently approximately 60% of all marketed drugs target membrane proteins. Although these classes of proteins are of high therapeutic interest, our understanding of their mechanism of action and structure remains limited. The first structure of a human GPCR was determined in 2007 and required the development of protein engineering and innovative crystallisation techniques. Since then, approximately 130 GPCR structures of less than 40 individual receptors have been determined providing insights into the structural arrangement of the transmembrane helices, ligand binding pockets and G protein interactions. Combined with spectroscopic methods, these studies allowed a more detailed understanding of the molecular aspects of GPCR activation and signalling. Despite the tremendous advances in GPCR structural biology, certain aspects of GPCR function still remain poorly understood. Due to their size and inherent flexibility, the interaction of protein and peptide ligands with their receptors remains a challenging aspect in the structural characterisation of GPCRs. Moreover, structural information on subtype selectivity of peptide ligands continues to be scarce. To contribute functional and structural information on the molecular mechanisms of peptide interactions with GPCRs, this thesis focused on characterising receptors from the chemoattractant cluster using radioligand binding assays as well as NMR spectroscopy.
The chemoattractant cluster mainly groups the kinin, angiotensin, anaphylatoxin chemotactic complement and apelin receptors according to conserved residues in their ligand binding cavities. All receptors in this cluster bind to peptide ligands deriving from high molecular weight protein precursors upon proteolytic processing. Comparable to the conserved binding pocket of the chemoattractant receptors, the peptide ligands display a certain sequence conservation although they differ strongly in size. The largest ligands used in this thesis are the anaphylatoxins complement 3a and 5a, comprising 77 or 74 residues, respectively. Due to their size and complex fold involving three intramolecular disulphide bonds, solid phase synthesis is impossible, which prompted us to develop a modified cell-free expression system to produce these ligands in tritiated form for subsequent functional characterisation of the complement receptors. To demonstrate the versatility of the developed system, it was applied to another disulphidebond containing peptide ligand, the 21 amino acid endothelin-1. We describe a reliable and multifaceted tool to generate custom labelled peptide ligands for the structural and functional characterisation of GPCRs. The system allows the production of custom radioligands, peptides labelled for NMR studies or with fluorescent amino acids.
Apart from the modulation of GPCR activity by orthosteric ligands, GPCR signalling has long been described to be regulated by allosteric ligands including peptides, small molecules and ions. In this thesis, the influence of sodium ions on the activity state of the chemoattractant cluster receptors and in particular on the apelin, bradykinin 2 and angiotensin II type 1 receptors was examined. In recent high resolution crystal structures an allosteric sodium ion pocket beneath the orthosteric ligand binding cavity was identified and residues contributing to the coordination of sodium ions are conserved throughout the chemoattractant cluster receptors. This allosteric sodium ion coordinated within the transmembrane domain bundle has been described to negatively influence the affinity of agonists but not of antagonists. It was found that sodium ions have distinct influences on the affinity state as well as the available number of binding sites of the chemoattractant receptors. In case of the apelin and bradykinin 2 receptors, sodium ions drastically reduced the number of available binding sites whereas the affinity of peptide ligands to the bradykinin 2 receptors remained constant and the ligand binding affinities to the apelin receptor were completely abolished. In contrast, the angiotensin II type 1 receptor affinity state towards the endogenous peptide ligand angiotensin II is highly dependent on the presence of sodium ions, whereas binding of the synthetic peptide antagonist Sar1-Ile8-angiotensin II remained unaffected by the sodium ion concentration. As differential effects irrespective of the efficacy class but dependent on the amino acid composition of the applied ligands are observed, it can be concluded that electrostatic interactions between charged residues of the peptide ligands and amino acids on the extracellular surface of the receptors are influenced by sodium ions thereby adding another layer of complexity on GPCR signalling.
To elucidate the structure-function relationship of ligand selectivity between the kinin receptors, the structure of desArg10-kallidin (DAK) bound to the bradykinin 1 receptor was determined using solid state NMR (SSNMR) in the course of this thesis. The kinin peptides DAK and bradykinin bind with high affinity and high selectivity to either the bradykinin 1 or bradykinin 2 receptor, respectively. The binding pockets of the receptors are highly conserved and the two peptide ligands only differ in one amino acid at their N- and C-termini whereas the remaining eight amino acids are fully conserved. DAK adopts a U-shaped structure when bound to the bradykinin 1 receptor which resembles a horse shoe-like conformation. Using 2D TEDOR spectroscopy it could furthermore be demonstrated that positively charged residues at the N-terminal part of the peptide engage in ionic interactions with negatively charged amino acids on the extracellular surface of the bradykinin 1 receptor. In contrast, bradykinin displays a distinct b-turn at the C-terminus and an S-shaped conformation of the N-terminal segment when bound to the bradykinin 2 receptor. By using SSNMR to study the binding mode of DAK on the bradykinin 1 receptor we could determine that subtype selectivity between the kinin receptors is conferred by distinct conformational restraints within the peptide ligands and by the formation of specific ionic interaction between charged residues on the peptide and receptor, respectively.
In brief, this thesis contributes structural and functional data on the binding mechanisms and binding mode of different peptide-ligand GPCRs helping to understand subtype selectivity and allosteric modulation of the chemoattractant cluster receptors. In addition, a versatile cell-free expression system was developed that allows the custom synthesis of isotopically labelled peptides containing disulphide bonds for the functional characterisation of GPCRs.
Melt segregation inside the earth consists of two different processes: 1) Generation of partially molten rock and 2) separation of melt, produced from partially molten rock, from the solid residual matrix. This thesis focuses on the later process. The 2 phase flow dynamics combines the study of flow dynamics of melt and matrix. Several studies have given the background theoretical frameworks for the flow dynamics of melt inside the earth. [McKenzie, 1984] summarizes the studies of [Ahern and Turcotte, 1979; Frank, 1968; Sleep, 1975] and gives a complete set of governing equations for the 2-phase flow problem.
[Bercovici et al., 2001] gives a general formulation considering the univariate system of equations related to matrix and melt flow which includes the interfacial surface force. The assumption of melt having negligible viscosity compare to the matrix has been abandoned. Therefore, based on these formulations, we have constructed our numerical model and thereafter a fortran code PERCOL2D to get an insight of melt percolation process through porous media. Additionally, we have used the Helmhotz decomposition, which splits a smooth and rapidly decaying vector field into an irrotational vector field and an incompressible vector field [Srámek, 2007], for matrix and fluid viscosity in order to lower the number of linearly independent variables to minimize the computational complications. The melt residing at inter-granular areas of lithosphere, forms an interconnected network even at low porosity. Therefore, being less dense than the matrix, melt moves up through porous media due to its buoyancy. Compaction of matrix, which occurs to compensate the melt separation, is considered in this thesis, where the effective bulk and shear viscosity of matrix are function of melt fraction. We have effective bulk viscosity of matrix as inversely proportional to melt fraction. Porosity dependence of effective bulk and shear viscosity leads to stronger melt focusing in highly porous region like mid ocean ridges [Katz, 2008] since the ratio of bulk and shear viscosity is smaller (< 10) than the constant viscosity case for the porous waves having non dimensional amplitude 5% or higher. Moreover, it is observed in [Richard et al., 2012] that the solitary wave formed in porosity dependent viscous matrix settings are steeper than the one formed in the constant matrix viscosity setting.
Firstly some 1D numerical experiments with PERCOL2D have been carried out using fixed and periodic boundary conditions for zero source term (i.e. no melting or no freezing) and negligible surface tension.
3 series of model setups with different initial conditions have been carried out varying the width, non-dimensional amplitude and the background porosity value of the initial input of porous wave.
A mathematical derivation for 1D solitary wave solution for the two phase flow through porosity dependent compacting media, is obtained in this thesis which is different than the study of [Barcilon and Lovera, 1989; Barcilon and Richter, 1986; Scott and Stevenson, 1984; Spiegelman, 1993a,b] as the effective viscosity of matrix is constant there.
Although [Simpson and Spiegelman, 2011] gives the solitary wave solutions in 1D, 2D and 3D considering the porosity dependent effective viscosity of the matrix, but using the small background porosity approximation, they neglect the background porosity (i.e φ0) and therefore the effect of variation of compaction lengths, which causes variation in the shape and dynamics of the solitary wave. Therefore, the study [This thesis, Richard et al., 2012] can be used for more general purpose. Solitary waves in varying viscous medium, are steeper (cf fig.5.1) compared to the one in constant viscous medium and their speed decreases as an inverse function of the background porosity. Additionally, this analytical solution is used in our code PERCOL2D and also in FDCON for numerical benchmarking (1D) of PERCOL2D.
The role of melt grain contiguity is considered in the revised viscosity formulation [Schmeling et al., 2012] based on elastic moduli theory of a fluid filled poro-elastic medium. This formulation is used in this thesis to produce a comparative dispersion relationship between speed of the wave and the non dimensional amplitude of porous wave, based on both the viscosity formulations (fig. 6.20) where one can see that the model based on [Bercovici et al., 2001] formulation, converges to the same dispersion relationship obtained from [Simpson and Spiegelman, 2011]. Whereas, the dispersion relationship using [Schmeling et al., 2012] formulations, shows time-dependent decrease of phase velocity with increasing amplitude and it is not yet clear that whether these solutions converge to steady state porosity waves before the porosity becomes 1.
Amid increasing regulation, structural changes of the market and Quantitative Easing as well as extremely low yields, concerns about the market liquidity of the Eurozone sovereign debt markets have been raised. We aim to quantify illiquidity risks, especially such related to liquidity dry-ups, and illiquidity spillover across maturities by examining the reaction to illiquidity shocks at high frequencies in two ways:
a) the regular response to shocks using a variance decomposition and,
b) the response to shocks in the extremes by detecting illiquidity shocks and modeling those as ultivariate Hawkes processes.
We find that:
a) market liquidity is more fragile and less predictable when an asset is very illiquid and,
b) the response to shocks in the extremes is structurally different from the regular response.
In 2015 long-term bonds are less liquid and the medium-term bonds are liquid, although we observe that in the extremes the medium-term bonds are increasingly driven by illiquidity spillover from the long-term titles.
Most defined contribution pension plans pay benefits as lump sums, yet the US Treasury has recently encouraged firms to protect retirees from outliving their assets by converting a portion of their plan balances into longevity income annuities (LIA). These are deferred annuities which initiate payouts not later than age 85 and continue for life, and they provide an effective way to hedge systematic (individual) longevity risk for a relatively low price. Using a life cycle portfolio framework, we measure the welfare improvements from including LIAs in the menu of plan payout choices, accounting for mortality heterogeneity by education and sex. We find that introducing a longevity income annuity to the plan menu is attractive for most DC plan participants who optimally commit 8-15% of their plan balances at age 65 to a LIA that starts paying out at age 85. Optimal annuitization boosts welfare by 5-20% of average retirement plan accruals at age 66 (assuming average mortality rates), compared to not having access to the LIA. We also compare the optimal LIA allocation versus two default options that plan sponsors could implement. We conclude that an approach where a fixed fraction over a dollar threshold is invested in LIAs will be preferred by most to the status quo, while enhancing welfare for the majority of workers.
Am 27. Dezember 2015 verabschiedete der Ständige Ausschuss des Nationalen Volkskongresses das erste Antiterrorgesetz in der Geschichte der Volksrepublik China (VRC). Damit wurde eine über 25 Jahre erarbeitete umfangreiche Antiterrorstrategie zu Papier gebracht und mit ihr endlich eine verbindliche rechtliche Definition von „Terrorismus.“ Bereits gängige Praktiken wie öffentliche Medienzensur oder die Verpflichtung von Telekommunikationsunternehmen und Internetprovidern zur Bereitstellung von Inhaltsdaten wurden formalisiert und verschärft, sowie auch die Mobilisierung zivilgesellschaftlicher Organisationen auf eine rechtliche Grundlage gestellt. Allerdings stellt das Gesetz nur den finalen, formalen Schritt einer fünfundzwanzigjährigen Entwicklung dar. Tatsächlich kämpft Beijing seit Anfang der 1990er Jahre in der Provinz Xinjiang mit einer Mischung aus separatistisch und islamistisch motivierter politischer Gewalt, an deren Spitze seit spätestens 2008 das East Turkestan Independence Movement (ETIM) steht. ETIM weist ideell und organisatorisch eine Nähe zu Al Qaeda auf, und arbeitet transnational mit der Islamischen Bewegung Usbekistans, Tehrik-i-Taliban (Pakistan) und der al-Nusra Front (Syrien) zusammen...
Systemic co-jumps
(2016)
The simultaneous occurrence of jumps in several stocks can be associated with major financial news, triggers short-term predictability in stock returns, is correlated with sudden spikes of the variance risk premium, and determines a persistent increase (decrease) of stock variances and correlations when they come along with bad (good) news. These systemic events and their implications can be easily overlooked by traditional univariate jump statistics applied to stock indices. They are instead revealed in a clearly cut way by using a novel test procedure applied to individual assets, which is particularly effective on high-volume stocks.
This paper addresses whether and to what extent econometric methods used in experimental studies can be adapted and applied to financial data to detect the best-fitting preference model. To address the research question, we implement a frequently used nonlinear probit model in the style of Hey and Orme (1994) and base our analysis on a simulation stud. In detail, we simulate trading sequences for a set of utility models and try to identify the underlying utility model and its parameterization used to generate these sequences by maximum likelihood. We find that for a very broad classification of utility models, this method provides acceptable outcomes. Yet, a closer look at the preference parameters reveals several caveats that come along with typical issues attached to financial data, and that some of these issues seems to drive our results. In particular, deviations are attributable to effects stemming from multicollinearity and coherent under-identification problems, where some of these detrimental effects can be captured up to a certain degree by adjusting the error term specification. Furthermore, additional uncertainty stemming from changing market parameter estimates affects the precision of our estimates for risk preferences and cannot be simply remedied by using a higher standard deviation of the error term or a different assumption regarding its stochastic process. Particularly, if the variance of the error term becomes large, we detect a tendency to identify SPT as utility model providing the best fit to simulated trading sequences. We also find that a frequent issue, namely serial correlation of the residuals, does not seem to be significant. However, we detected a tendency to prefer nesting models over nested utility models, which is particularly prevalent if RDU and EXPO utility models are estimated along with EUT and CRRA utility models.
Microeconomic modeling of investors behavior in financial markets and its results crucially depends on assumptions about the mathematical shape of the underlying preference functions as well as their parameterizations. With the purpose to shed some light on the question, which preferences towards risky financial outcomes prevail in stock markets, we adopted and applied a maximum likelihood approach from the field of experimental economics on a randomly selected dataset of 656 private investors of a large German discount brokerage firm. According to our analysis we find evidence that the majority of these clients follow trading pattern in accordance with Prospect Theory (Kahneman and Tversky (1979)). We also find that observable sociodemographic and personal characteristics such as gender or age don't seem to correlate with specific preference types. With respect to the overall impact of preferences on trading behavior, we find a moderate impact of preferences on trading decisions of individual investors. A classification of investors according to various utility types reveals that the strength of the impact of preferences on an investors' rading behavior is not connected to most personal characteristics, but seems to be related to round-trip length.
Shortcomings revealed by experimental and theoretical researchers such as Allais (1953), Rabin (2000) and Rabin and Thaler (2001) that put the classical expected utility paradigm von Neumann and Morgenstern (1947) into question, led to the proposition of alternative and generalized utility functions, that intend to improve descriptive accuracy. The perhaps best known among those alternative preference theories, that has attracted much popularity among economists, is the so called Prospect Theory by Kahneman and Tversky (1979) and Tversky and Kahneman (1992). Its distinctive features, governed by its set of risk parameters such as risk sensitivity, loss aversion and decision weights, stimulated a series of economic and financial models that build on the previously estimated parameter values by Tversky and Kahneman (1992) to analyze and explain various empirical phenomena for which expected utility doesn't seem to offer a satisfying rationale. In this paper, after providing a brief overview of the relevant literature, we take a closer look at one of those papers, the trading model of Vlcek and Hens (2011) and analyze its implications on Prospect Theory parameters using an adopted maximum likelihood approach for a dataset of 656 individual investors from a large German discount brokerage firm. We find evidence that investors in our dataset are moderately averse to large losses and display high risk sensitivity, supporting the main assumptions of Prospect Theory.
Ongoing demographic change will lead to a relative scarcity of raw labor to the effect that output growth will be decreasing in the next decades, a secular stagnation. As physical capital will be relatively abundant, this decrease of output will be accompanied by reductions of asset returns. We quantify these effects for the US economy by developing an overlapping generations model with risky and risk-free assets. Without adjustments of human capital, risky returns decrease until 2035 by about 0.7 percentage point, and the risk-free rate by about one percentage point, leading to substantial welfare losses for asset rich households. Per capita output is reduced by 6%. Endogenous human capital adjustments strongly mitigate these effects. We conclude that human capital policies will be crucial in the context of labor shortages.
We study whether the presence of low-latency traders (including high-frequency traders (HFTs)) in the pre-opening period contributes to market quality, defined by price discovery and liquidity provision, in the opening auction. We use a unique dataset from the Tokyo Stock Exchange (TSE) based on server-IDs and find that HFTs dynamically alter their presence in different stocks and on different days. In spite of the lack of immediate execution, about one quarter of HFTs participate in the pre-opening period, and contribute significantly to market quality in the pre-opening period, the opening auction that ensues and the continuous trading period. Their contribution is largely different from that of the other HFTs during the continuous period.
The equity trading landscape all over the world has changed dramatically in recent years. We have witnessed the advent of new trading venues and significant changes in the market shares of existing ones. We use an extensive panel dataset from the European equity markets to analyze the market shares of five categories of lit and dark trading mechanisms. Market design features, such as minimum tick size, immediacy and anonymity; market conditions, such as liquidity and volatility; and the informational environment have distinct implications for order routing decisions and trading venues' resulting market shares. Furthermore, these implications differ distinctly for small and large trades, probably because traders jointly optimize their trade size and venue choice. Our results both confirm and go beyond current theoretical predictions on trading in fragmented markets.
Using two datasets containing demographically representative samples of the Dutch population, I study how lifetime experiences of aggregate labor market conditions affect personality. Three sets of findings are reported. First, experienced aggregate unemployment is negatively correlated with the levels of all Big Five personality traits, except for conscientiousness (no significant correlation). Second, in panel data models with individual fixed effects I find that changes in experienced aggregate unemployment cause changes in emotional stability and agreeableness for men, and conscientiousness for women. The correlation is positive, and effects are economically large. Thirdly, I report suggestive evidence that the main driver is experienced aggregate unemployment, instead of other macroeconomic variables as experienced GDP, stock market returns or inflation. Taken together, these findings suggest that changes in Big Five personality traits are systematically related to experienced aggregate labor market conditions.
This paper is the outcome of a related broader project, exploring the explanatory power of the Legal Theory of Finance, which proposes a new institution-based analytical framework for the analysis of phenomena of financial markets. One of its most important theoretical assumptions, the legal construction of financial markets, is highlighted by the example of the private creation of money by structured finance products in this paper. Further implications can then be shown referring to pari passu clauses and collective action clauses, which are both exhibit a differential application of these legal rules according to the hierarchical status of the respective market participant, and can therefore endanger sovereign debt restructurings. Legal instruments to avoid this are briefly explored. An example of another key role of the law in crisis that is the task to resolve the tension between market discipline and financial stability is exemplified by the regulation of the OTC derivatives market and proposals of effective loss-sharing among CCPs. Related questions about the significance of legal rules to ensure financial stability are raised in the analysis of minimum capital requirements under Basel III.
Na temelju terenskoga istraživanja u radu se donosi sinkronijski prikaz naglasnih paradigma imenica e-vrste i i-vrste u slivanjskim govorima Slivna Ravnoga, Mihalja, Blaca i Podgradine. Riječ je o govorima koji pripadaju istočnohercegovačkomu dijalektu, slivanjsko-zažapskomu govornom tipu. Utvrdit će se postoje li kolebanja u pojedinoj paradigmi i među paradigmama te čuvanje kračine u d./l./i.
Rad opisuje jedan od dvaju interpunkcijskih znakova (središnje crte i navodnici) koji bitno odstupaju od odnosa jednoga znaka za jedno (unikodno) značenje. Dok navodnici imaju višestruke grafeme (točnije, osam) za jedno značenje, središnje crte najčešće imaju dva grafema (kraća i dulja crta) koja pokrivaju čak 11 (unikodnih i latiničnih) crtnih znakova. Dok je kriterij crtne duljine tradicionalno visoko istaknut u pravopisnim priručnicima, u predstavljenoj se kategorizaciji on nalazi tek na šestoj hijerarhijskoj razini. Osim što su u međuvremenu standardizirana dva nova unikodna crtna znaka (two-em dash i three-em dash, Unicode 6.1, siječanj 2012.), drugačija metodologija i uspoređivanje jezičnopovijesnoga i računalnojezikoslovnoga aspekta proširila je spoznaje o crtnim znakovima u hrvatskome jeziku o kojima je pisano u Portada i Stojanov (2009). Predstavlja se kategorizacija osjetljiva na dihotomiju grafičkoga prikaza i značenja koja sve crtne znakove dijeli u pet hijerarhijskih razina. Između 44 unikodna vodoravna i neprekinuta crtna znaka, podjelom prema tipu, vremenu, funkciji, smjeru i visini, došlo se do 11 latiničnih suvremenih pismovnih vodoravnih središnjih znakova među kojima svaki latinični jezik odabire svoje crtne znakove. Svim se crtnim unikodnim grafemima opisalo značenje i uporaba. S druge strane, crtni se znakovi promatraju u kroatističkoj jezičnopovijesnoj pravopisnoj perspektivi. U odnosu na bogati repozitorij unikodno standardiziranih crtnih znakova utvrdilo se da je pravopisna norma bitno redukcijska. Pravopisno normiranje crtnih znakova podijelilo se u dva razdoblja i tri skupine, ovisno o grafemskome obliku (prva i druga generacija pravopisnih pri ručnika) i nazivlju (prijestandardna faza i dva standardna smjera normiranja ovisno o prihvaćanju terminoloških parova spojnica – crtica i crtica – crta). Na temelju jezičnopovijesnoga i računalnojezikoslovnoga poredbenog istraživanja te na temelju supostavljanja unikodne standardizacije crtnih znakova pravopisnoj tradiciji opisa središnjih crta željelo se ukazati na (i) potrebu za širim i interdisciplinarnim pristupom opisa pisane jezične prakse, (ii) nedovoljnost opisa školske razine pravopisnih priručnika za suvremeno pisanje, kao i na (iii) nedostatnost postojeće kroatističke kodifikacije obaju terminoloških smjerova. Da bi se pravopisni priručnici mogli nazvati znanstveno utemeljenim djelima, u znatnijoj bi mjeri trebali opisati računalno pisanje i na razini interpunkcije uvesti razlikovanje znaka i grafema. Jedno od takvih mjesta opisa prema kojima bi pravopisi mogli unaprijediti svoju tehnološku suvremenost jest pitanje pisanja spojnice na početku prelomljena retka o čemu se iznijelo osam argumenata za odbacivanje aktualne tradicije. Raščlamba je pokazala da ima opravdanosti da se crtna kodifikacija temelji na trima ili četirima znakovima koji se iz 11 unikodnih latiničnih znakova svode uspostavljanjem osnovnih skupina središnjih crta, radno nazvanih c1, c2, c3 i c4 kao najkraća, srednje duga, duga i jako duga središnja crta.
U hrvatskoj jezikoslovnoj tradiciji element se formalni je pokazatelj pripadnosti pojedinoga glagola skupini povratnih glagola. Taj se element dosad smatrao zamjenjivim zamjenicom sebe u tzv. pravih povratnih glagola. U ovome se radu na temelju postavaka više autora (Zec 1985, Sells, Zaenen i Zec 1987, Moskovljević 1997, Medová 2009, Oliva 2010) pokušava dokazati neistovjetnost elemenata se i sebe. Slobodna zamjena tih dvaju elemenata rezultira promjenom značenja i gramatičkom neovjerenošću. Iz toga proizlazi i drugačija podjela povratnih glagola. U radu će se usporedbom nekoliko povratnih glagola i njihovih prijelaznih parnjaka iznijeti drugačiji pristup povratnim glagolima.
“Institutional Overburdening” to a large extent was a consequence of the “Great Moderation”. This term indicates that it was a period in which inflation had come down from rather high levels. Growth and employment were at least satisfying and variability of output had substantially declined. It was almost unavoidable that as a consequence expectations on future actions of central banks and their ability to control the economy reached an unprecedented peak which was hardly sustainable. Institutional overburdening has two dimensions. One is coming from exaggerated expectations on what central banks can achieve (“expectational overburdening”). The other dimension is “operational overburdening” i.e. overloading the central bank with more and more responsibilities and competences.
U radu se daje analiza i prikaz tvorbenoga sustava umanjenica u kajkavskome narječju. Analiza je provedena na primjerima iz objavljenih dijalektoloških opisa govora, kajkavskih rječnika te iz vlastite građe. U tvorbenome se opisu polazi sa sinkronijskoga stanovišta, a povijesnojezične se napomene donose tek sporadično. Navode se svi u građi potvrđeni sufiksi za tvorbu umanjenica muškoga, srednjega i ženskoga roda. Uz svaku se tvorbenu kategoriju navode i jezične značajke koje se odnose na glasovne promjene na granici osnove i sufiksa.
The loss and restoration of the phoneme /j/ plays a major role in the development of Proto-Slavic. After vowel contraction in posttonic syllables, Dybo’s law, and the rise of new /j/ in east, South, and West Slavic, contracted and uncontracted forms may have coexisted during a considerable period of time. After Dybo’s law we have *voļȃ < *vòlja "will" but *rolьjà < *orlь̀ja "plowland", after contraction *roļá in Slovincian rolåu, Old Polish rolå. The loss of distinctive tone yielded merger of the two paradigms, as a result of which most nouns of the former type adopted the accentuation of the latter. Slavic deverbal ja-stems are original proterodynamic ī/jē-stems. The proterodynamic nouns *dūšà (c) "soul" and *zorjà (c) "dawn" have probably preserved the original accentuation. The other proterodynamic jā-stems evidently adopted the accent pattern of the deverbal ā-stems.
Rad se bavi analizom svojstava, funkcija i markera konverzacijkih implikatura u SMS diskursu. U prvome dijelu članka utvrđuju se temeljni mehanizmi prijenosa implicitnih intencionalno enodiranih sadržaja u diskurs te se određuju obilježja jezične strukture i govorne produkcije tipična za dopisivanje putem SMS poruka. Diskurs SMS dopisivanja smatra se plodnim područjem za proučavanje implikatura zbog bogatstva implicitnim sadržajima (uvjetovanoga sažetošću SMS forme); posrednosti komunikacije koja iziskuje jezično ili znakovno markiranje implikatura te specifičnih načina prijenosa i signaliziranja implicitnih sadržaja. U drugome dijelu rada predstavljaju se paralingvistički i jezični markeri konverzacijskih implikatura koji su se temeljem analize korpusa SMS dopisivanja pokazali najzastupljenijima u upotrebi. Cilj je rada ukazati na specifičnosti SMS diskursa kada su u pitanju sredstva i mehanizmi enkodiranja, signaliziranja te uspješnoga dekodiranja implicitnih sadržaja.
This note discusses the basic economics of central clearing for derivatives and the need for a proper regulation, supervision and resolution of central counterparty clearing houses (CCPs). New regulation in the U.S. and in Europe renders the involvement of a central counterparty mandatory for standardized OTC derivatives’ trading and sets higher capital and collateral requirements for non-centrally cleared derivatives.
From a macrofinance perspective, CCPs provide a trade-off between reduced contagion risk in the financial industry and the creation of a significant systemic risk. However, so far, regulation and supervision of CCPs is very fragmented, limited and ignores two important aspects: the risk of consolidation of CCPs on the one side and the competition among CCPs on the other side. i) As the economies of scale of CCP operations in risk and cost reduction can be large, they provide an argument in favor of consolidation, leading at the extreme to a monopoly CCP that poses the ultimate default risk – a systemic risk for the entire financial sector. As a systemic risk event requires a government bailout, there is a public policy issue here. ii) As long as no monopoly CCP exists, there is competition for market share among existing CCPs. Such competition may undermine the stability of the entire financial system because it induces “predatory margining”: a reduction of margin requirements to increase market share.
The policy lesson from our consideration emphasizes the importance of a single authority supervising all competing CCPs as well as of a specific regulation and resolution framework for CCPs. Our general recommendations can be applied to the current situation in Europe, and the proposed merger between Deutsche Börse and London Stock Exchange.
U radu se donose rezultati deskriptivnog terminološkog opisa istraživanja provedenog na jednojezičnom korpusu predmetnog područja znanosti o kršu. Semaziološki orijentiranim pristupom provodi se distribucijska analiza terminoloških jedinica i njihovih supojavnica u diskursu. Oslanjajući se na leksičko-gramatički model, kreiraju se pojmovne klase na temelju dvojnosti sintagmatskih i paradigmatskih relacija. U opisu sintagmatskih jedinica posebna se pozornost posvećuje ulozi pridjevskih riječi kao kvalifikatora, ali i nositelja specijaliziranog značenja. Aktivna uloga pridjeva prikazuje se metodom parafraziranja značenja s obzirom na klase pojmova koje pridjev determinira. Analiza pridjeva u terminološkim sintagmama upućuje na višedimenzionalno dinamično strukturiranje pojmovnih struktura specijaliziranog područja znanja.
Die aktuelle Diskussion über eine Reform der gesetzlichen Rentenversicherung vermischt Fragen nach dem durchschnittlichen Rentenniveau mit Fragen der Umverteilung von Einkommen im Ruhestand zur Bekämpfung einer etwaigen Altersarmut. Dieser Beitrag kritisiert diesen Ansatz und befasst sich mit fünf Kernaussagen: (1) Die aktuell gültige Rentenformel darf unter keinen Umständen abgeschafft werden. (2) Das Renteneintrittsalter sollte an die durchschnittliche Restlebenserwartung nach dem Erreichen des 65. Lebensjahres gekoppelt werden. (3) Eine Integration der Flüchtlinge in den Arbeitsmarkt wird das Rentenniveau in den Jahren 2030 bis 2040 stützen. (4) Sollte trotz allem die Altersarmut steigen, so kann dem durch die Einführung einer Mindestrente begegnet werden. (5) Die private Altersvorsorge muss weiter gestützt werden.
The Intensifying Function of Modal Particles and Modal Elements in a Cross-Linguistic Perspective
(2015)
The aim of this paper is to analyze the intensifying function of German modal particles and equivalent modal expressions in Croatian and English. Our hypothesis is that some modal particles in German and their functional equivalents in Croatian and English can express different degrees of intensity and types of intensification. The presented study comprises two parts. First, the use of intensifying modal particles by a group of speakers of L1 Croatian and L2 German/English is investigated. On the basis of the results obtained, and by means of a previously conducted corpus analysis (cf. Kresić and Batinić 2014), an intensification scale with respect to the inventory of German modal particles and corresponding particles in Croatian as well as equivalent English expressions is suggested. Some German and Croatian modal particles and equivalent modal elements in English can be classified on the upper and partially on the lower part of the proposed intensification scale when compared to the norm, i.e. an utterance unmarked by a modal particle.
U ovom se radu prijevodi starogrčkih tragedija Bratoljuba Klaića promatraju u odnosu na njegove prethodnike te na zahtjeve onovremene recepcije antičkih dramskih tekstova. Na odabranim se primjerima iz Sofoklovih drama Antigona i Kralj Edip, a u usporedbi sa starijim prijevodima Kolomana Raca, analizira status Klaićeva prijevoda u odnosu na izvornik, određuju bitna načela njegove prevoditeljske metodologije te uočavaju strategije kojima rješava neke od problema interpretacije starogrčkoga teksta.
Pogled u radom ispunjen život Bratoljuba Klaića pokazuje širinu njegovih interesa i pobuđuje na misao o tom što bi hrvatsko jezikoslovlje moglo napraviti da je djelovalo u povoljnijim uvjetima. Svakako je književnost i kazalište izrazito privlačilo našeg proučavatelja, osobito hrvatska književnost, grčka i rimska, pa je prirodno njegovo sudjelovanje u ediciji Pet stoljeća hrvatske književnosti. Među hrvatskim piscima davnih stoljeća osobito su ga zanimali Hanibal Lucić, Petar Hektorović, Marin Držić i Ivan Gundulić, ali se je pozabavio i komedijom Ljubovnici, kao i novijim piscima Šenoom, Matošem, Ujevićem, Krležom, Kolarom i drugima. Znatnu je pozornost posvetio i folkloru tumačeći njegove jezične značajke. Na zanimljiv način bavio se je akcentom, osobito kad je riječ o akcentu starih pisaca hrvatskih i o naglasku u njihovim suvremenim izvedbama. Bratoljub Klaić bio je jedan od znanstvenika što su hrvatsku književnost tumačili kao prirodnu cjelinu pisaca raznih stoljeća, iz raznih predjela i različitih dijalekatnih osobina.
Metalepsa je u naratologiji definirana kao postupak prekoračenja granice između fikcije i stvarnosti, književnog i izvanknjiževnog (Genette 1972, 2004). Vodeći se tom definicijom što je uključuje K. Bagić (2012.) u smislu figure koja iziskuje novo promišljanje statusa granice u narativnom tekstu, u članku će se analizirati metalepsa unutar autoironijskog postupka poigravanja funkcijama književnog teksta u autobiografskoj humoresci "Priča o bezmesnom ručku" (Pripovijetke, 2009.) Bratoljuba Klaića. Poigravanje metanarativnim komentarima tzv. kanonske hrvatske književnosti prisutno je u drugoj humoresci iz iste zbirke, pod naslovom „Baba Lizino janješceˮ. Cilj rada je prikazati stilske i naratološke osobitosti Klaićeva proznog stvaralaštva, i to s naglaskom na postupcima kojima autor konstruira specifičan humoristični učinak utemeljen na obratu i odmaku od uspostavljenih unutartekstualnih i izvantekstualnih odnosa. Uključivanje metalepse, potkopavanje granice između fikcije i stvarnosti, književnog i neknjiževnog, metanarativnost, autoreferencijalnost, kao i samo ironiziranje funkcija književnosti te društva u kojemu ona nastaje i unutar kojega ostvaruje recepciju, ukazuju na to da se Klaićev izraz, unatoč prividnoj lakoći i jednostavnosti, mjestimice približava poetičkim odrednicama postmoderne. Istraživanje njegovih pripovjednih tekstova stoga može dati zanimljive rezultate i u ključu suvremenih spoznaja teorije pripovijedanja kad su u pitanju postupci ostvarivanja humora, pa čak i šire – kada je u pitanju tekstualno konstruiranje identiteta subjekta unutar autobiografskog diskursa.
Već je i površnim pregledom u Klaićev Rječnik stranih riječi vidljivo da je Miroslav Krleža najcitiraniji književnik, a natuknice kod kojih se na njega upućuje su posuđenice, tuđice, strane riječi pa i cijeli rečenični citati na stranom jeziku. U radu se daje raščlamba natuknica koje Klaić povezuje s Krležom.
U radu se ukratko prikazuje Klaićev opis bizovačkoga govora i podjela donjopodravskih govora na dva međusobno ponešto različita tipa: valpovački akcenatski tip govora – okolica Bizovca do Donjega Miholjca – i šaptinovački akcenatski tip – od Donjega Miholjca prema Virovitici. Obilježja bizovačkoga govora uspoređuju se s govorom Podravskih Podgajaca.
U radu se ponajprije na temelju sklonidbe jednosložnih imenica o-osnova iznose temeljne razlike u uspostavi naglasnih tipova u Klaićevim djelima Rječnik stranih riječi i Naglasni sustav standardnoga hrvatskog jezika te Školskoga rječnika hrvatskoga jezika Instituta za hrvatski jezik i jezikoslovlje i Školske knjige. Zajednička je navedenim djelima dosljedna provedba novoštokavskih naglasnih pravila te nastojanje za usustavljivanjem naglašivanja. Razlike se odnose na odabir naglasnih tipova koji su u Klaićevim djelima utemeljeni na starijim jezičnim priručnicima i dijalektološkoj građi, a u Školskome su rječniku zasnovani na odrazima praslavenskih naglasnih paradigma. Iz rada je razvidno da bi Klaićev doprinos usustavljivanju naglašivanja u hrvatskome standardnom jeziku bio znatno veći da je njegov naglasni priručnik bio otisnut kad je nastao. U radu se navode i razlike u naglascima u suvremenim hrvatskim rječnicima koje su djelomično posljedicom nedostatka pravogovornih priručnika te selektivnoga odstupanja od novoštokavskih naglasnih pravila.
Članak analizira akcenatski sustav valpovačkoga podravskog govora na temelju Klaićeva opisa govora Bizovca. Usporedba njegova opisa s opisima drugih dijalektologa vodi do zaključka da su razlike između postojećih opisa valpovačke akcentuacije znatne te da je Klaićev opis od svih opisa najdetaljniji i najpouzdaniji. Drugi dio članka opisuje akcenatsku karakteristiku koja dijeli valpovački govor od ostalih slavonskih govora: povlačenje naglaska s dočetnoga sloga prozodijske riječi na početni slog. Navode se neke tipološke paralele iz drugih hrvatskih govora, zatim ruskoga i litavskoga jezika. Potvrđena je teza, koju je zastupalo više jezikoslovaca, da je povlačenje naglaska posljedica utjecaja mađarskog jezika na valpovački govor.
Brojni naglasni "tipovi" prvi put detaljno popisani u radovima Đ. Daničića bili su povod mnogim akcentološkim radovima u XX. st. Cilj im je prije svega bio učiniti naglasnu tipologiju jednostavnijom i preglednijom te upozoriti na (ne)aktualnosti naglasnih uzoraka koji su se dugo prepisivali i prenosili u literaturi. Šireuporabno neprimjenljiva Daničićeva naglasna tipologija bila je povod i Klaićevu (1963.) pokušaju smanjenja broja tipova, i to polazeći od proklize, osvrćući se na povijest jezika i na dijalekte. Prenošenje naglaska na proklitiku zahtijeva dobro poznavanje povijesti jezika tako da se to sažimanje ne doima šire uporabljivim, no svakako otvara pitanja kojima se i danas bavimo, a to je pitanje (ne)prenošenja naglaska na proklitiku i pitanje broja uzoraka promjenljivoga naglasnoga tipa. Analizom Klaićeve naglasne tipologije, koja se nameće iz njegovih radova, želimo pokazati koliko je odmaknula od Daničićeva tipologiziranja i koliko je bliska današnjim prikazima.
Baveći se (kao recenzentica) djelom Bratoljuba Klaića Naglasni sustav standardnoga hrvatskog jezika, Klaićev me način bilježenja naglasaka podsjetio i na nešto starije gramatike hrvatskoga jezika i na bilježenje naglasaka u tim gramatikama, pa se tim uspoređivanjem vrlo lako uočava razlika između pisanja naglasaka „nekad i sad”, premda to „nekad” i nije bilo tako davno. Kako su u hrvatskoj kroatistici akcentološka djela rijetka, prilika je da se na skupu posvećenu između ostaloga i akcentologu Bratoljubu Klaiću progovori nešto više o razlikama u bilježenju hrvatskih naglasaka u Klaićevo vrijeme (prije pedesetak godina) i u vrijeme bliže današnjemu, jer su te razlike od vremena pisanja Klaićeva djela do danas očite. U svojem izlaganju osvrnula sam se na poteškoće u novijem bilježenju hrvatskih standardnih naglasaka, poglavito na slogovima s dugim refleksom staroga glasa jata,te o razlozima koji su do njih doveli. Usredotočila sam se poglavito na Klaićevo i današnje pisanje naglasaka na nekadašnjoj tzv. dugoj (dvosložnoj) zamjeni jata – koliko god to neki lingvisti tretirali kao dvoglasnik ie, ipak se riječi kao snijeg, brijeg i sl. mogu rastaviti na slogove, dakle ipak su posrijedi dva sloga, a ne jedan – jer upravo u tome i jesu razlike između Klaićeva bilježenja naglasaka i onih današnjih u standardološkim djelima.
Rječnik stranih riječi Bratoljuba Klaića prepoznat je kao ozbiljan, pouzdan i relevantan priručnik ne samo u stručnim krugovima nego i u širokome krugu zainteresiranih korisnika. Razlogom je takve posvemašnje zainteresiranosti nedvojbeno njegova obavijesnost i preglednost, ali i prikladnost leksikografske obradbe. Dobar dio rječničkoga korpusa Klaićeva Rječnika čine glagolske natuknice koje se u rječničkome članku obrađuju kao polazna i kao izvedena natuknica. U radu se razmatraju glagolske natuknice obrađene u prvim četirima izdanjima (1 1951., 2 1958., 3 1962., 4 1966.) jer su to jedina izdanja s Klaićevim autorskim potpisom. Propituje se status glagolskih natuknica u rječničkoj makrostrukturi, ustroj rječničkoga članka s glagolskom natuknicom kao polaznom ili izvedenom natuknicom te osobito primarne i sekundarne podatke o natuknici koji prikazuju prozodijske, morfološke, rječotvorne, etimološke, stilske, terminološke i semantičke obavijesti o glagolskoj natuknici.
U radu se propituje status općeeuropskih frazema hrvatskoga jezika u izdanjima Rječnika stranih riječi Bratoljuba Klaića. Pod općeeuropskim se frazemima podrazumijevaju međunarodni frazemi potvrđeni u europskim jezicima s jednakim značenjem i velikom strukturnom podudarnošću. Za te je frazeme važno da najčešće imaju poznat zajednički izvor, tj. podrijetlo, ali postoje i općeeuropski frazemi kojima još nije utvrđeno točno podrijetlo, odnosno jezik i tekst iz kojega su uzeti i prošireni. Stoga je cilj rada utvrditi i opisati status općeeuropskih frazema u Klaićevu Rječniku stranih riječi. Naime, Bratoljub Klaić u njemu donosi vrijedne podatke o izvoru pojedinoga frazema, izreke ili poslovice. Pri tome su u Rječnik uključeni općeeuropski frazemi kojima je sastavnicom strano vlastito ime, strani apelativ ili termin ili je riječ o prevedenicama iz latinskoga i drugih jezika. Dolazi se do zaključka da Klaićev rječnik može, kao nezaobilazno polazište nekom budućem hrvatskom etimološkom frazeološkom rječniku, biti važnim izvorom proučavanju podrijetla frazema.
Unter der Leitung des Gothaer Medailleurs Christian Wermuth (1661-1739) wurden zugleich drei Medaillen geschaffen und zum freien Verkauf angeboten, die an die poetische Krönung von Sidonia Hedwig Zäunemann (1711-1740) erinnern. Von der als Universität der Aufklärung konzipierten Göttinger Universität literarisch ausgezeichnet, war die Erfurter Autorin die neunte von insgesamt 21 kaiserlich gekrönten Dichterinnen. Die treibenden Kräfte hinter dem Verleihungsakt standen unter dem Eindruck der durch die Universität Wittenberg vorgenommenen exzeptionellen Ehrung von Zäunemanns Vorgängerin Christiana Mariana von Ziegler (1695-1760). Den hohen Prestigewert der Göttinger Krönung belegen neben Lobgedichten und Berichten in Zeitungen und gelehrten Journalen auch die Krönungsmedaillen. Deren kulturpolitische Signalfunktion erschließt sich aus dem Sinn und Zweck, der den zwei Frauenkrönungen auf Seiten ihrer Initiatoren zugedacht war. Ein in Gotha entstandenes Werbeblatt zu den "curieuse[n] und wohl inventierte[n] Medaillen", datiert auf den 19. September 1738, gibt Aufschluss über die kreativen Köpfe, die als Nicht-Medailleure zum Gelingen dieses wohl auch unter kompetitiven Gesichtspunkten außergewöhnlichen künstlerischen Projektes unter Mitarbeit eines Medaillenverfertigers namens Grauel beitrugen. Eine aus den Quellen gearbeitete Zeittafel zum Krönungsjahr und die Mitteilung einer in der Wermuth-Forschung unbekannten Variante der kleinen Zäunemann-Medaille runden den literatur-, kunst- und kulturwissenschaftlich perspektivierten Beitrag ab.
The neural crest gives rise to the neurons and glial cells of the peripheral nervous system (PNS) (Bronner-Fraser and Fraser, 1989; Frank and Sanes, 1991). Self-renewing neural crest-derived stem cells (NCSCs) are present in migratory neural crest and various postmigratory locations, including peripheral ganglia (Duff et al., 1992; Morrison et al., 1999; Kruger er al., 2002). It is demonstrated that NCSCs from embryonic mouse dorsal root ganglia (DRG) are reprogrammed in neurosphere (NS) cultures in the presence of EGF and FGF. Reprogrammed NCSCs (rNCSCs) generate exclusively central nervous system (CNS) progeny, both in vitro and upon transplantation into the mouse brain (Binder et al., 2011). In this study the timing and mechanisms underlying the reprogramming were addressed. Most of the cells acquire CNS characteristics at passage 2, reaching a stable proportion of >90% of Olig2-positive cells at passage 3, which is maintained at least up to passage 10. The PNS marker p75 is completely lacking from passage 3 onwards. Furthermore, it was shown that the reprogramming does not involve a transient pluripotency state. This suggests a direct reprogramming of NCSCs to cells with CNS identity. The reprogramming leads to a stable CNS identity as shown by delayed BMP4 application. This result is in agreement with the previous observation that rNCSCs only generate CNS progeny, in particular mature myelinating oligodendrocytes, upon transplantation into embryonic, postnatal and lesioned adult mouse brains (Binder et al., 2011). Genome wide gene expression profiles of rNCSC NS demonstrates already in culture a complete switch to a (spinal cord stem cell) SCSC CNS identity. These results demonstrate a complete reprogramming of PNS progenitors to CNS identity without genetic modification and imply PNS cells as a source for stem cell-based CNS therapy.
The reprogramming of NCSCs is completely blocked in the presence of BMP4 in NS cultures, as shown by the expression of neural crest markers p75 and Sox10. In addition, BMP4 NCSCs generate PNS neurons (Tuj1/Phox2b- and Peripherin/Tuj1-coexpressing cells) and Schwann cells (O4/p75-coexpressing cells). Genome wide gene expression profiles of BMP NCSCs demonstrate that BMP NCSCs express genes at high levels which are characteristic for neural crest/neural crest derivatives, mesenchymal derivatives of neural crest and perivascular pericytes/MSCs. On the other hand CNS marker genes are restricted to rNCSCs and are only expressed at background or undetectable levels in BMP NCSCs. These findings imply that the CNS versus PNS identity is controlled by antagonistic functions of FGF and BMP4.
The use of rNCSCs for cell therapies requires an accessible source of these cells in the adult organism. Since the DRG is not an easily approachable tissue source, the adult mouse palate, containing NCSCs, was chosen. These results suggest that pNCSCs arise from Sox10-positive neural crest-derived stem cells, that downregulate PNS marker gene expression, such as Sox10 and p75, in NS culture. Contrary to rNCSCs, CNS marker upregulation was not observed. Notably, genome wide gene expression profiles of pNCSCs demonstrate an enrichment of genes expressed by mesenchymal derivatives and perivascular pericytes/mesenchymal stem cells. Since the cranial crest gives rise, besides PNS neural progeny and melanocytes, to mesenchymal derivatives, the results demonstrate that pNCSCs have a restricted developmental potential in comparison to rNCSCs and acquire mostly normal fates of the cranial neural crest.
Taken together, the results demonstrate that rNCSCs acquire a SCSC identity in the presence of EGF and FGF and that the reprogramming can be efficiently blocked by BMP4. On the other hand, NCSCs derived from adult palate rather acquire mesenchymal fates and do not acquire a CNS identity under the conditions used.
This is the ninth post in the blog series „Movements and Institutions“.
This article disputes the conceptualization of institutionalization as a one-way process. Instead, it argues that social movement organizations can make use of contentious tactics while being institutionalized. The environmental NGO Birdlife Malta provides an example to illustrate this argument
n traditional portfolio theory, risk management is limited to the choice of the relative weights of the riskless asset and a diversified basket of risky securities, respectively. Yet in industry, risk management represents a central aspect of asset management, with distinct responsibilities and organizational structures. We identify frictions that lead to increased importance of risk management and describe three major challenges to be met by the risk manager. First, we derive a framework to determine a portfolio position's marginal risk contribution and to decide on optimal portfolio weights of active managers. Second, we survey methods to control downside risk and unwanted risks since investors frequently have non-standard preferences which make them seek protection against excessive losses. Third, we point out that quantitative portfolio management usually requires the selection and parametrization of stylized models of financial markets. We therefore discuss risk management approaches to deal with parameter uncertainty, such as shrinkage procedures or re- sampling procedures, and techniques of dealing with model uncertainty via methods of Bayesian model averaging.
Tulasnella species (Tulasnellaceae, Cantharellales, Basidiomycota) form inconspicuous basidiomata on rotten branches or trunks of trees, difficult to find and recognize in nature. However, according to ultrastrucural and molecular data, species of Tulasnellaceae are the most frequent mycorrhriza forming fungi (mycobionts) of green, photosynthetic orchids worldwide. Species of Tulasnellaceae were also found as prominent mycobionts of the extraordinary diverse orchids in tropical montane rainforest of Southern Ecuador. Orchids obligately depend on mycobionts during the juvenile stage when the fungi have to deliver carbon to the non-photosynthetic protocorm and thus the fungi substantially influence the establishment of orchids in the wild. Species of Tulasnellaceae can acquire carbon from decaying bark or wood by specific saprotrophic capabilities as was recently proven through comparative genomics that included data on decay enzymes from Tulasnella cf. calospora isolated from orchid mycorrhizae (Anacamptis laxiflora, Italy). Thus, species of Tulasnellaceae can be saprotrophs and symbionts simultaneously.
It is currently under discussion, whether specific species of Tulasnella are required for seed germination and establishment of distinct terrestrial and epiphytic orchids in nature or if species of Tulasnella are generalists concerning their association with orchids. The inconsistences in species concepts and taxonomy of Tulasnella spp., however, strongly impede progress in this field of research. The aim of the present study was, therefore, to revise the species concepts by combining, for the first time, morphological and molecular data from basidiomata.
Specimens were collected in tropical Andean forest in Southern Ecuador and in temperate forests in Germany. Additional specimens were loaned from fungaria. In total, 205 specimens, corresponding to 16 own samples and 189 specimens from fungaria were analyzed. The mycobiont relationships of Tulasnella spp. with orchids from the sampling area in Ecuador were studied in populations of Epidendrum rhopalostele. The basis for molecular-phylogenetic analysis was completed by data obtained from own previous investigations on mycobionts from the investigation area and Tulasnella isolates from Australia.
30 morphospecies are illustrated and delimited by a morphological key based on traditional species concepts. Tulasnella andina from Ecuador and Tulasnella kirschneri from China are presented as species new to science. Tulasnella cruciata is described from herbarium material for the first time. Tulasnella aff. eichleriana and T. violea are reported for the first time from Ecuador. Molecular sequences of two Tulasnella spp. isolated from mycobionts of Epidendrum rhopalostele cannot be related to any morphological species concept. Statistical analyses suggest that conventional diagnostic using morphological characteristics is ambiguous for delimiting morphologically similar species.
For the first time sequences of the ITS-5.8S rDNA region were obtained after cloning from fresh basidiomata. Extraction of DNA from herbarium specimens was, however, unsuccessful. Sequences from 16 fresh basidiomata, six pure cultures, and sequences of orchids mycorrhizae (e.g. from Epidendrum rhopalostele) available in the database GenBank were analyzed. Proportional
variability of ITS-5.8S rDNA sequences within and among cultures and within and among specimens were used to designate morphospecies. Results suggest an intragenomic variation of less than 2 %, an intraspecific variation of up to 4 % and an interspecific divergence of more than 9 % for Tulasnella spp.
Four percent of intraspecific divergence was defined as a minimum threshold for delimiting phylogenetic species. This threshold corroborates the so far used 3 % to 5 % divergence in delimitation of operational taxonomic units of Tulasnella mycobionts.
Quite a number of sequences of Tulasnella are available in GenBank, mostly obtained from direct PCR amplification from orchid mycorrhizae. By including closely related sequences in the phylogenetic analysis, several morphological cryptic species of Tulasnella, mostly from Ecuador, were found. Arguments are given for molecular support of the new species Tulasnella andina and the established species Tulasnella albida, T. asymmetrica, T. eichleriana, T. tomaculum, and T. violea. Thus, by combining molecular and morphological data species concepts in Tulasnella are improved. The definitions of Tulasnella calospora and T. deliquescens, however, remain phylogenetically inconsistent.
The present investigation is a first step to expand our knowledge on the intraand interspecific morphological and molecular variability of Tulasnella spp. and to delimit species relevant for studies on ecology and communities of orchids and Tulasnellaceae.
The recent financial crisis has demonstrated that a failure of Systemically Important Financial Institutions (SIFIs) could seriously damage the stability of the financial system. A precise and consistent definition of a SIFI is pivotal to ensure efficient and effective regulation of the global financial sector. This paper proposes a threefold test logic that allows to classify Financial Institutions as systemically important across the various industry segments.
We provide a comprehensive analysis of the determinants of trading in the sovereign credit default swaps (CDS) market, using weekly data for single-name sovereign CDS from October 2008 to September 2015. We describe the anatomy of the sovereign CDS market, derive a law of motion for gross positions and their components, and identify the key factors that drive the cross-sectional and time-series properties of trading volume and net notional amounts outstanding. While a single principal component accounts for 54 percent of the variation in sovereign CDS spreads, the largest common factor explains only 7 percent of the variation in sovereign CDS net notional amounts outstanding. Moreover, unlike for CDS spreads, common global factors explain very little of the variation in sovereign CDS trading and net notional amounts outstanding, suggesting that it is driven primarily by idiosyncratic country risk. We analyze several local and regional channels that may explain the trading in sovereign CDS: (a) country-specific credit risk shocks, including changes in a country's credit rating and related outlook changes, (b) the announcement and issuance of domestic and international debt, (c) macroeconomic sentiment derived from conventional and unconventional monetary policy, macro-economic news and shocks, and (d) regulatory channels, such as changes in bank capital adequacy requirements. All our findings suggest that sovereign CDS are more likely used for hedging than for speculative purposes.
Using novel monthly data for 226 euro-area banks from 2007 to 2015, we investigate the determinants of changes in banks’ sovereign exposures and their effects during and after the crisis. First, public, bailed out and poorly capitalized banks responded to sovereign stress by purchasing domestic public debt more than other banks, with public banks’ purchases growing especially in coincidence with the largest ECB liquidity injections. Second, bank exposures significantly amplified the transmission of risk from the sovereign and its impact on lending. This amplification of the impact on lending does not appear to arise from spurious correlation or reverse causality.
The euro crisis was fueled by the diabolic loop between sovereign risk and bank risk, coupled with cross-border flight-to-safety capital flows. European Safe Bonds (ESBies), a union-wide safe asset without joint liability, would help to resolve these problems. We make three contributions. First, numerical simulations show that ESBies would be at least as safe as German bunds and approximately double the supply of euro safe assets when protected by a 30%-thick junior tranche. Second, a model shows how, when and why the two features of ESBies — diversification and seniority — can weaken the diabolic loop and its diffusion across countries. Third, we propose a step-by-step guide on how to create ESBies, starting with limited issuance by public or private-sector entities.
How do insiders trade?
(2016)
We characterize how informed investors trade in the options market ahead of corporate news when they receive private, but noisy, information about (i) the timing of the announcement and (ii) its impact on stock prices. Our theoretical framework generates a rich set of predictions about the insiders’ behavior and their maximum expected returns. Three different analyses offer empirical support for our approach. First, predicted trades resemble illegal insider trades documented in SEC litigation cases with insiders being more likely to trade in options that offer higher expected returns. Second, pre-announcement patterns in unusual activity in the options market ahead of significant corporate news are consistent with the predictions of our framework. We employ our approach to characterize informed trading ahead of twelve different types of news including the announcement of earnings, corporate guidance, M&As, product innovations, management changes, and analyst recommendations. Third, to address concerns that pre-announcement patterns are driven by speculation, we show that measures capturing trading activity in call (put) options with high expected returns predict significant positive (negative) corporate news in the aggregate cross-section.
Based on a unique data set of driving behavior we find direct evidence that private information has significant effects on contract choice and risk in automobile insurance. The number of car rides and the relative distance driven on weekends are significant risk factors. While the number of car rides and average speeding are negatively related to the level of liability coverage, the number of car rides and the relative distance driven at night are positively related to the level of first-party coverage. These results indicate multiple and counteracting effects of private information based on risk preferences and driving behavior.
Prestige and loan pricing
(2016)
We find that prestigious companies pay lower spreads and upfront fees on their loans despite the fact that prestige does not predict default risk over the life of the loan. Using survey data on firm-level prestige, we show that a one standard deviation increase in prestige reduces loan spreads by 6.18% per year and upfront fees by 22.86%. We identify causal effects (i) using fraud by industry peers as an instrument for borrower prestige and (ii) exploiting a regression discontinuity around rank 100 of the prestige survey. Banks that lend to prestigious firms attract more business afterwards compared to otherwise similar institutions. Moreover, the effect of prestige on upfront fees is particularly strong for new bank relationships. Our findings suggest that prestigious firms receive cheaper funding because the associated lending relationship helps banks establish valuable credentials they use to compete for future borrowers.
Data show that sovereign risk reduces liquidity, increases funding cost and risk of banks highly exposed to it. I build a model that rationalizes this fact. Banks act as delegated monitors and invest in risky projects and in risky sovereign bonds. As investors hear rumors of increased sovereign risk, they run the bank (via global games). Banks could rollover liquidity in repo market using government bonds as collateral, but as sovereign risk raises collateral values shrink. Overall banks’ liquidity falls (its cost increases) and so does banks’ credit. In this context noisy news (announcements with signal extraction) of consolidation policies are recessionary in the short run, as they contribute to investors and banks pessimism, and mildly expansionary in the medium run. The banks liquidity channel plays a major role in the fiscal transmission.
This paper uses recent legislation in Austria to establish a link between sovereign reputation and yield spreads. In 2009, Hypo Alpe Adria International, a bank previously co-owned by the regional government of Carinthia, had been nationalized by Austria’s central government in order to avoid a default triggering multi-billion Euro local government guarantees. In 2015, special legislation retroactively introduced collective action clauses allowing a haircut on both the bonds and the guarantees while avoiding formal default. We document that legislative and administrative action designed to partly abrogate the guarantees resulted in a loss of reputation, leading to higher yield spreads for sovereign debt. Our analysis of covered bonds uncovers an increase in yield spreads on the secondary market and a deterioration of primary market conditions.
Studies employing micro price data to examine the extent of international goods market integration tend to find that borders induce arbitrage-impeding transaction costs which contribute to segment national markets. Analyzing household scanner price data from the three euro area countries Belgium, Germany and Netherlands, we document that Belgian households living in the vicinity of the border to Netherlands pay almost 10% more for the same good as their Dutch counterparts. German consumers on the other hand face prices that are on average up to around 3% smaller than those in the neighboring Netherlands. Counterfactual evidence for within-country price discontinuities provides no evidence of any existing border effects. The induced costs of crossing national borders amount to at least 13%. We also find evidence on border discontinuities in various household preference characteristics (such as demand elasticities and goods valuation) and household shopping patterns such as shopping frequencies.
Studies employing micro price data suggest that price dispersion is larger between regions in different countries than between regions in the same country. To investigate the strength of this border effect, deviations from the law of one price are used in most studies to provide statistical evidence on the effect of borders on price dispersion. I propose an alternative measure of the economic costs of borders which has an explicit welfare-theoretic foundation. Employing a unique micro price data set from households in Belgium, Germany and the Netherlands I provide evidence on the economic importance of price differences for households. I find that price dispersion within countries has only small economic importance, but that price dispersion between Belgium and Germany (and Belgium and the Netherlands) has considerable economic importance.
Microeconometric evidence on demand-side real rigidity and
implications for monetary non-neutrality
(2016)
To model the observed slow response of aggregate real variables to nominal shocks, most macroeconomic models incorporate real rigidities in addition to nominal rigidities. One popular way of modelling such a real rigidity is to assume a non-constant demand elasticity. By using a homescan data set for three European countries, including prices and quantities bought for a large number of goods, in addition to consumer characteristics, we provide estimates of price elasticities of demand and on the degree of demand-side real rigidities. We find that price elasticites of demand are about 4 in the median. Furthermore, we find evidence for demand-side real rigidities. These are, however, much smaller than what is often assumed in macroeconomic models. The median estimate for demand-side real rigidity, the super-elasticity, is in a range between 1 and 2. To quantitatively assess the implications of our empirical estimates, we calibrate a menu-cost model with the estimated super-elasticity. We find that the degree of monetary non-neutrality doubles in the model including demand-side real rigidity, compared to the model with only nominal rigidity, suggesting a multiplier effect of around two. However, the model can explain only up to 6% of the monetary non-neutrality observed in the data, implying that additional multipliers are necessary to match the behavior of aggregate variables.
Die 5-Lipoxygenase (5-LOX) stellt den Startpunkt des Leukotrienstoffwechsels dar, da sie Arachidonsäure (AA) über die 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraensäure (5-HpETE) in Leukotrien A4 (LTA4) umwandelt. 5-HpETE kann zum korrespondierenden Alkohol 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraensäure (5-HETE) reduziert werden. LTA4 dient als Zwischenprodukt für die Synthese von LTB4 und den Cysteinyl-gebundenden LTs LTC4, LTD4 und LTE4. LTs nehmen eine wichtige Funktion in der Immunabwehr ein, sind jedoch auch an einer Vielzahl von Krankheitsgeschehen wie z. B. Asthma bronchiale, Atherosklerose und einiger Tumorarten beteiligt. Die 5-LOX teilt sich in zwei Domänen auf: der reglatorischen, N-terminalen Domäne und der katalytischen, C-terminalen Domäne. Ihre Aktivität unterliegt einer komplexen allosterischen Regulation und kinetischen Besonderheiten wie einer Substratinhibition. In vielen Fällen ist die regulatorische PLAT-(Polycystin-1, Lipoxygenase, alpha-Toxin)-Domäne involviert. Sie ist essentiell an der Bindung von Calcium, Membranen und weiterer Faktoren wie dem Coactosin-like protein (CLP) und Dicer beteiligt. Auch eine zweite Bindungsstelle für das Substrat oder einen seiner Metaboliten wird dort vermutet. Letztlich bleibt jedoch die Regulation der 5-LOX-Aktivität durch die PLAT-Domäne unzureichend geklärt. Diese Tatsache und die fortwährende Suche nach neuen Ansatzpunkten für die 5-LOX-Inhibition bilden den Hintergrund, vor dem diese Arbeit angefertigt wurde.
Das Ziel lag in der Entwicklung einer stabilen, isolierten PLAT-Domäne und deren Charakterisierung. Es stellte sich jedoch heraus, dass sich die isolierte Domäne durch eine hohe thermische Instabilität und starke Aggregationsneigung auszeichnet. Mittels Mutationsstudien auf Basis der 5-LOX AS 1-115, verbunden mit Gelfiltrationsläufen zur Analyse der Proteinaggregation, wurde schließlich ein Konstrukt entwickelt, das in Konzentrationen < 0,5 mg/ml als Monomer vorlag: die sogenannte PLAT1-115 W75G. Ein Austausch des W75 in Glycin erhöhte ebenfalls die thermische Stabilität, so dass Versuche bei 20°C durchgeführt werden konnten. Zunächst wurden jedoch die grundlegenden Eigenschaften der Mutante untersucht. Dies umfasste die Beantwortung der Frage, ob auch die PLAT1-115 W75G Calcium bindet, sowie die Aufnahme eines Circulardichroismus-(CD)-Spektrums. Der erste Aspekt konnte mit mehreren Methoden bestätigt werden. Eine Calciumzugabe zum Laufpuffer 20 mM MOPS, 50 mM KCl pH 7,4 erhöhte konzentrationsabhängig das Elutionsvolumen der PLAT1-115 W75G auf der analytischen Gelfiltrationssäule – vermutlich durch den bekannten Einfluss von Calcium auf die Hydrophobizität der PLAT-Domäne. Zusätzlich wurde die Interaktion durch differential scanning fluorimetry (DSF) und Oberflächen-Plasmonen-Resonanz-Spektroskopie (SPR) nachgewiesen. Allerdings gelang aus verschiedenen Gründen keine Quantifizierung der Bindungsaffinität. Das CD-Spektrum bestätigte die Struktur der PLAT-Domäne als sogenanntes all-beta_protein und ermöglichte die Einordnung der PLAT1-115 W75G in die Gruppe der betaII-Proteine.
Ein weiterer Fokus dieser Arbeit lag auf der vermuteten allosterischen Fettsäurebindungsstelle in der PLAT-Domäne. Es wurde versucht, die Interaktion mittels SPR nachzuweisen. Zur Vorbereitung wurde im 5-LOX-Aktivitätstest und im DSF an der isolierten Domäne ein Detergens bestimmt, das einen möglichst geringen Einfluss auf das Protein ausübt. Dabei zeigte Octyl-beta-D-glucopyranosid (beta-OG) das vorteilhafteste Profil. Auf dieser Basis wurde die kritische Mizellbildungs-Konzentration (CMC) der AA und einiger HETEs in beta-OG-haltigen Puffern bestimmt. Die SPR-Studien ergaben jedoch keine reproduzierbaren Ergebnisse. In einem weiteren Schritt wurden die Substrathemmung des Gesamtproteins 5-LOX und der Einfluss von Calcium charakterisiert. Sowohl in Gegenwart von ~ 1 mM freiem Calcium als auch von 1 mM EDTA lag mit 20 µM AA die höchste Produktbildung nach 10-minütiger Reaktion vor. Das Detergens Tween20 (T20) hob in einer Konzentration unter seiner CMC (0,001 % m/V) in Anwesenheit von Calcium die Inhibition auf. Ohne Calcium zeigte sich auch in Gegenwart von T20 die bekannte Substratinhibition der 5-LOX einschließlich ihrer Maximalaktivität bei 20 µM AA. Diese Ergebnisse deuten darauf hin, dass Calcium eine Bindung der 5-LOX an eventuell vorhandene, negativ geladene Vesikel aus AA und Detergens vermitteln und dadurch die Substratinhibition aufheben kann. In Fällen, in denen die Substratinhibition vor dem Erreichen der AA-CMC auftritt, hat Calcium folglich keinen Einfluss.
Zuletzt wurde die Interaktion der PLAT1–115 W75G mit CLP und einem C-terminalen Fragment von Dicer untersucht. Im Crosslinking ließ sich nicht auf eine Interaktion der isolierten PLAT-Domäne mit CLP schließen. Dagegen ergaben Diamid-Crosslinking-Studien, dass die isolierte PLAT-Domäne in der Lage ist, das Dicer-Fragment zu binden. Dieses Ergebnis wurde im SPR bestätigt.
Acute myeloid leukemia is a hematopoietic stem cell disorder and a type of acute leukemia which is characterized by clonal proliferation of myeloid precursors with a reduced capacity to differentiate into more mature cellular elements. Clinically AML is characterized by a high degree of heterogeneity with respect to chromosome abnormalities, gene mutations, and changes in expression of multiple genes and microRNAs. Cytogenetic abnormalities can be detected in approximately 50% to 60% of newly diagnosed AML patients. Majority of AML cases are associated with chromosomal aberrations, more specifically translocations that often result in gene arrangements and expression of aberrant fusion proteins. This study was carried out with two fusion proteins: PML/RARα and DEK/CAN which results from the translocations t(15;17) and t (6,9) respectively. PML/RARα is the most common translocation (97%) and the main driver in Acute Promyelocytic Leukemia (APL), a wellcharacterized and well treatable subtype of AML. In contrast, DEK/CAN occurs in 1-5% of AML, associated with poor prognosis and defines a high risk group in AML. The expression of PML/RARα results in a fusion protein that acts as a transcriptional repressor by interfering with gene expression programs involved in differentiation, apoptosis, and selfrenewal. Current therapy focused on the targeting of PML/RARα fusion protien. Success has been achieved by using either ATRA, anthracyclines and Arsenic trioxide or their combinations. These agents induce differentiation in PML/RARα positive AML and hence called differentiation therapy. In comparison with ATRA, ATO and anthracyclines are poor cellular differentiation agents. Despite early promise, several studies have reported that differentiation therapy is unable to target/eradicate leukemic stem cells or eradicate the disease. Therefore current therapeutic focus is to eliminate leukemic stem cells and achieve complete molecular remission not only in APL but also in acute lymphoblastic leukemia and chronic myeloid leukemia as well. Key enzymes of the eicosanoid pathways in the arachidonic acid metabolism, such as COX1/2 as well as the 5-LO have been shown to be good targets for leukemic stem cell therapy approach in AML by interfering with the Wntsignaling which is known to be indispensable for the pathogenesis of AML. Recently it was reported that the third eicosanoid pathway based on the cytochrome P450 (CYP) enzymes interferes with Wnt-signaling as well as with the proliferation and mobilization of hematopoietic stem cells...
Different types of altruistic behavior, namely help-giving, altruistic punishment, and moral courage, are identifiable and distinguishable in the literature, but little is known how they relate to each other. This is significant because understanding altruism and other-regarding behavior is important in the attempt to solve global problems of overpopulation and depletion of natural resources. Understanding the helping forms of altruism (help-giving and sharing) can be helpful, for example, when designing donation collections or recruiting volunteers. Understanding the punitive forms of altruism (moral courage and altruistic punishment) gives valuable insight on individuals participating in campaigns where there is a need to take action, for example, against polluters or governments that violate human rights. The empirical evidence presented in this dissertation demonstrate individual and cultural differences in help-giving, altruistic punishment, and morally courageous behavior. The willingness to engage in the three types of altruistic behaviors relate differently to subjectively preferred thinking style and to personality traits, both in real-life and on the Internet. The divergencies are observable between Eastern (Indian) and Western (German) cultures, where the overlap of oneself and other individuals is experienced in different levels.
The planned Facility for Antiproton and Ion Research (FAIR) at GSI has to cope with a wide range of beam intensities in its high-energy beam transport systems and in the storage rings. To meet the requirements of a non-intercepting intensity measurement down to nA range, it is planned to install a number of Cryogenic Current Comparator (CCC) units at different locations in the FAIR beamlines. In this work, the first CCC system for intensity measurement of heavy ion beams, which was developed at GSI, was re-commissioned and upgraded to be used as a 'GSI - CCC prototype' for extensive optimization and development of an improved CCC for FAIR. After installation of a new SQUID sensor and related electronics, as well as implementation of improved data acquisition components, successful beam current measurements were performed at a SIS18 extraction line. The measured intensity values were compared with those of a Secondary Electron Monitor (SEM). Furthermore, the spill-structure of a slowly extracted beam was measured and analyzed, investigating its improvement due to bunching during the slow-extraction process. Due to the extreme sensitivity of the superconducting sensor, the determined intensity values as well as the adjustment of the system for optimal performance are strongly influenced by the numerous noise sources of the accelerators environment. For this reason, detailed studies of different effects caused by noise have been carried out, which are presented together with proposals to reduce them. Similarly, studies were performed to increase the dynamic range and overcome slew rate limitations, the results of which are illustrated and discussed as well. By combining the various optimizations and characterizations of the GSI CCC prototype with the experiences made during beam operation, criteria for a more efficient CCC System could be worked out, which are presented in this work. The details of this new design are worked out with respect to the corresponding boundary conditions at FAIR. Larger beam tube diameters, higher radiation resistivity and UHV requirements are of particular importance for the cryostat. At the same time these parameters affect the CCC superconducting magnetic shielding, which again has significant influence on the current resolution of the system. In order to investigate the influence of the geometry of the superconducting magnetic shield on different magnetic field components and to optimize the attenuation, FEM simulations have been performed. Based on the results of these calculations, modifications of the shield geometry for optimum damping behavior are proposed and discussed in the thesis.
Die vorliegende Arbeit untersuchte die Chancen und Restriktivitäten einer künstlerischen Ausbildung. Welche Möglichkeiten stehen einer künstlerischen Ausbildung zur Verfügung und welchen Grenzen steht sie unüberwindlich gegenüber? Diese waren konstitutionstheoretisch zu entfalten und wissenschaftspraktisch anhand von mir erhobenem Datenmaterial (vornehmlich Interviews mit Studenten und Professoren von Kunsthochschulen in Deutschland) zu belegen bzw. zu verdichten...
Die Einstellung von onkologisch tätigen Ärzten zur psychoonkologischen Versorgung von Krebspatienten
(2015)
Eine Krebserkrankung stellt für die Betroffenen und deren Angehörige eine große körperliche und psychische Belastung dar. Obwohl die psychoonkologische Betreuung den Patienten nachweislich hilft und die Belastung vieler Patienten sehr hoch ist, erhält nur cirka jeder fünfte therapiebedürftig belastete Krebspatient eine psychoonkologische Behandlung. Für die Umsetzung einer flächendeckenden psychoonkologischen Betreuung der Patienten nehmen die onkologisch tätigen Ärzte eine Schlüsselrolle ein. Deshalb ist für die Implementierung und das Gelingen eines Screenings bzw. der psychoonkologischen Versorgung der Patienten das Engagement und die psychosoziale Kompetenz der behandelnden Ärzte eine entscheidende Größe.
Um die Einstellung von onkologisch tätigen Ärzten zur psychoonkologischen Versorgung zu erfassen, wurde ein Fragebogen als Erhebungsinstrument konstruiert. Die Konstruktion des Fragebogens erfolgte auf Grundlage der Theorie des geplanten Handelns nach Ajzen (2002). Zusätzlich zu der Einstellung der behandelten Ärzte erfasst der Fragebogen die Selbstwirksamkeit der Ärzte in Bezug auf psychosoziale Kompetenzen, sowie die organisatorischen Rahmenbedingungen in der Klinik.
Zwischen September und Dezember 2013 wurden an der Universitätsklinik Frankfurt am Main insgesamt 120 Fragebögen an onkologisch tätige Ärzte ausgeteilt von denen 102 beantwortet wurden (Rücklaufquote von ca. 85%). Zur Validierung des Fragebogens wurde die Korrelation einzelner Skalen mit der Skala „Interaktion und Verhalten“ nach Spearman berechnet. Insgesamt korrelierten die Skalen in die zu erwartende Richtung, jedoch waren die Korrelationskoeffizienten geringer ausgeprägt als erhofft (zwischen 0,26 und 0,36). Die interne Konsistenz (nach Cronbachs Alpha) der Skalen erreichte bis auf eine Ausnahme ein akzeptables bis gutes Niveau.
Die Ergebnisse der vorliegenden Studie zeigen keinen Hinweis darauf, dass die Diskrepanz zwischen der hohen Anzahl an belasteten Krebspatienten und der seltenen Inanspruchnahme von psychoonkologischen Behandlungen durch die Einstellung der Ärzte zur Psychoonkologie erklärt werden kann. Im Gegenteil, in dieser Studie wird der psychoonkologischen Versorgung von Patienten eine hohe Wertigkeit zugeschrieben: 76 % der Ärzte sind der Meinung, sie würden, wenn sie selbst erkranken, davon profitieren mit einem Psychoonkologen zu sprechen. Auch empfehlen 79 % der Befragten ihren Freunden oder Angehörigen im Falle einer Krebserkrankung eine psychoonkologische Beratung. Trotz der über die Stichprobe insgesamt sehr positiven Einstellung gegenüber der psychoonkologischen Versorgung, divergieren die Aussagen hinsichtlich der Häufigkeit, in der Skala „Umsetzung und Interaktion“, die erfasst wie häufig psychoonkologische Aspekte in die Behandlung von onkologischen Patienten integriert werden, immens.
Die individuelle Handhabung der Weitergabe von Informationen von Seiten der Ärzte in dieser Studie kann teilweise durch mangelhafte organisatorische Rahmenbedingungen erklärt werden: So gibt fast die Hälfte der Befragten (45 %) an, in ihrer Abteilung gebe es kein standardisiertes Screeningverfahren, um psychisch belastete Patienten zu identifizieren. Ebenso sind bei ca. der Hälfte der Ärzte (45 %) keine klaren Richtlinien vorhanden, wann eine psychoonkologische Beratung indiziert ist.
Die Erkenntnisse dieser Studie geben Hinweise darauf, dass für die Verbesserung der psychoonkologischen Versorgung von Patienten die organisatorischen Rahmenbedingungen an den Kliniken optimiert werden müssen.
Life-saving pig-to-human xenotransplantation is a promising technology with the potential to balance the shortage of human organs in allotransplantation. Before this approach is applied on solid vascularized organs, several barriers must be overcome. Patient safety is menaced by infectious porcine endogenous retroviruses (PERV) which are able to infect human cell lines in vitro. Successful infection with PERV is associated with diverse life-threatening consequences including gene disruption, tumorigenicity, immune suppression as well as PERV proliferation throughout the whole human body. This could cause a catastrophic xenozonoosis leading to the emergence of new forms of pathogens and pandemic diseases similar to AIDS. However, in vivo, there is hitherto no incidence of any infection with PERV in preclinical xenotransplantations performed in the past.
PERV infection of human peripheral blood mononuclear cells (huPBMC) is a critical issue discussed controversially in several studies. It is essential to address the sensitivity of huPBMC to infection by PERV since it is generally one of the first retroviral targets upon viral invasion and infection of the human body. To assess definitely if huPBMC are infected productively by PERV, target cells were challenged with the highest infectious PERV class, recombinant PERV-A/C, in different assays. Modern and standard methods to detect PERV at different stages of viral cycles were used to monitor PERV development upon contact with host cells. Indeed, PERV-A/C in supernatants of producer cell lines failed to infect mitogen-activated huPBMC. Neither retroviral reverse transcriptase (RT) nor viral RNA packaged in virus particles were observed in supernatants of cells exposed to viral supernatants. In addition, provirus was not detected in huPBMC until 56 days p. i. with PERV-A/C. Independently of the virus load applied, culture conditions of huPBMC or administration of polybrene as enhancer, PERV was unable to infect huPBMC. Results suggest that PERV in supernatants lack sufficient infectious potential to be productively generated in huPBMC.
In order to approximate xenotransplantation scenarios, different PERV producing cells including PHA-activated porcine PBMC (poPBMC) were adopted as virus source in co-cultivation studies with huPBMC. In this case, expression of viral RNA was successfully measured. However, RT activity did not increase until 28 days p. e. with PERV producer cells which indicates that viral particles devoid of infectious capacity were released from non-productively infected cells.
On the other hand, co-cultivation of both virus producer and virus recipients increases the contact pressure between PERV and target cells. Consequently, PERV was able to be detected at least as provirus in huPBMC. Although virions produced were not functional, presence of provirus in infected cells will sooner or later provoke expression of provirus. This could lead to chromosomal rearrangements as well as virus reinfection and insertional mutagenesis.
Ecotropic PERV-C displays a restricted host range to porcine cells. Given its ability to serve as template to form recombinant xenotropic PERV-A/C, PERV-C represents a potent hazard in the course of xenotransplantation. Thus, isolation and functional characterization of PERV-C in the genome of pigs in use and intended for xenotransplantation is necessary to analyze the genetics of these virions as well as to select animals lacking proviral PERV-C or to generate transgenic PERV-C negative donors.
PERV-C was isolated from the genome of a female SLAd/d haplotype pig via screening of a bacteriophage library which was constructed from the genomic DNA of poPBMC extracted from this PERV non-transmitting sow. Upon genetic complementation of provirus using a PCR fragment infectious ability of full-length PERV-C clones was investigated in cell culture. PERV-C clones were successfully reproduced in susceptible porcine cells as RT activity as well as viral RNA were detected in supernatants of infected cells 56 days p. i. Furthermore, presence of proviruses in challenged cells was confirmed by nested PCR.
PERV-C clones were also isolated from a bacteriophage library generated on genomic DNA of an Auckland island pig of the DPF colony, whose individuals display a PERV-null phenotype and are already in use for xenotransplantation, and of a Göttingen minipig, whose relatives serve as animal models to study human diseases. In contrast to PERV clones isolated from the female SLAd/d haplotype sow PERV-C clones of the Auckland island pig as well as of the Göttingen minipig were not functional and therefore unable to infect target cells. This confirms the PERV-null phenotype which renders these animals putative candidates as donors in xenotransplantation. On the other hand, presence of functional PERV-C in SLAd/d haplotype pigs exerts a negative impact on patient safety in xenotransplantation. The suitability of these animals as potent organ donors should be intensively investigated.
In conclusion, PERV of all classes pose a virological risk in xenotransplantation which should not be ignored. Since exclusion of all PERV from donor herds is impossible, generation of transgenic humanized animals lacking genomic infectious PERV represents the best strategy to guarantee patient safety in future life-saving pig-to-human xenotransplantation.
Reaktive Sauerstoffspezies lösen molekular Schäden aus und werden als möglicher Auslöser des Alterungsprozesses gesehen. Sie sind allerdings auch wichtige Signalgeber, deren Einfluss in den letzten Jahren immer mehr Beachtung findet. Im der vorliegenden Arbeit wurde die Signalwirkung von ROS auf das Alternsmodell P. anserina untersucht. Dabei konnten folgende Erkenntnisse gewonnen werden.
1. Die H2O2–Konzentration im Extrazellularraum und im Cytoplasma steigt bei PQ-Stress und während des Alterns an.
2. Bei PQ-Stress und während des Alterns treten Ähnlichkeiten der globalen Transkriptregulation auf, die vermutlich durch die angestiegene H2O2-Konzentration ausgelöst werden.
3. Die Transkriptmenge von SODs und die Gesamt-SOD-Aktivität sind bei PQ-Stress leicht herunterreguliert. Transkripte für PaCCP1 und PaCATB treten dagegen bei PQ-Stress vermehrt auf und auch die Gesamt-Katalase-Aktivität steigt an. Dies deutet darauf hin, dass der Fokus des enzymatischen Abbaus von ROS bei PQ-Stress nicht im Abbau von Superoxid-, sondern von Wasserstoffperoxid liegt.
4. Bei PQ-Stress steigt die Transkriptmenge von Schlüsselgenen der Carotinoid-Biosynthese.
5. Transkripte von mitochondrial lokalisierten Proteinen werden bei PQ-Stress stark hochreguliert, die Menge an Mitochondrien nimmt allerdings nicht zu. Dies deutet auf einen verstärkten Abbau mitochondrialer Proteine, gefolgt von einer Neusynthese hin.
6. Bei PQ-Stress sinkt die Expression von Genen, die für den Kupferimport benötig werden. Dies wird höchstwahrscheinlich durch die Inaktivierung des Transkriptionsfaktors GRISEA ausgelöst. Es kommt zu einem Kupfermangel, der eine verstärkte alternative PaAOX-abhängige Atmung auslöst und dafür sorgt, dass kupferabhängige Prozesse, wie die Melanin- und Sterigmatocystin-Synthese transkriptionell herunterreguliert werden. Durch die verringerte Transkriptmenge von Kupferimportern bei PQ-Stress kommt es zu starken Gemeinsamkeiten in der globalen Genregulation von PQ-gestressten Kulturen und der Kupfer-depletierten Mutante grisea.
7. Kupfer und PQ haben einen synergistisch negativen Effekt auf Wuchsrate und Lebensspanne von P. anserina. Bei hohen Kupfer und Superoxid-Konzentrationen kommt es vermutlich zur verstärkten Bildung von Hydroxyl-Radikalen, wodurch molekulare Schäden entstehen. Durch eine verringerte Kupferkonzentration wird der Organismus bei PQ-Stress möglicherweise vor der Bildung von Hydroxyl-Radikalen geschützt.
Insgesamt haben die Untersuchungen gezeigt, dass ROS wichtige Signalmoleküle sind, die einen starken Einfluss auf die Regulation von Transkripten haben. Viele dieser transkriptionellen Regulationen führen zu physiologischen Veränderungen. Der Fokus der Regulationen liegt unter den verwendeten Bedingungen im Schutz vor den schädlichen Effekten von ROS.
We have studied one-proton-removal reactions of about 500MeV/u 17Ne beams on a carbon target at the R3B/LAND setup at GSI by detecting beam-like 15O-p and determining their relative-energy distribution. We exclusively selected the removal of a 17Ne halo proton, and the Glauber-model analysis of the 16F momentum distribution resulted in an s2 contribution in the 17Ne ground state of about 40%.
Die Anschläge in diesem Sommer in ganz Europa sowie der andauernde Kampf gegen den Islamischen Staat haben das Thema der Terrorbekämpfung auch in der Öffentlichkeit wieder ganz nach oben auf die Tagesordnung gesetzt. Ob nun auf Länderebene oder durch neue Maßnahmen auf Bundesebene und International – eine ganze Reihe weiterer Maßnahmen wurden beschlossen um die Terrorbekämpfung in Deutschland zu verbessern. Ebenso wurden auch in anderen Ländern neue Maßnahmen beschlossen, in Frankreich sogar der Ausnahmezustand bis Anfang 2017 verlängert. Gleichzeitig brachten die neuen Maßnahmen auch eine Diskussion über die Sinnhaftigkeit, Effizienz und Effektivität dieser Maßnahmen mit sich – und ebenso, wie weit eine demokratische Gesellschaft in ihrem Sicherheitsbedürfnis überhaupt gehen soll. An diese Diskussion soll diese Blogserie anschließen...
An analysis of the UK's counter-terrorism strategy, CONTEST, and the challenges in its evaluation
(2016)
The UK’s Counter-Terrorism strategy, known as CONTEST, is recognized as one of the most successful soft-focus strategies in the world, with an intended emphasis on community support and what have become known as ‘Prevent’ (or counter-extremism) measures. In all, there are four limbs to CONTEST: PREVENT, PROTECT, PURSUE and PREPARE. While there is much crossover between these areas, for example policing activities take place in all four limbs, each one has a specific focus with its own intrinsic goals. This article intends to provide an overview of CONTEST, and to explore the challenges of evaluating counter-terrorism strategies in general. In doing so, I intend to show that while robust and independent evaluation of CONTEST has not been undertaken from a quantitative approach, some level of evaluation has taken place and can be taken into consideration when moving forward with future analysis of the strategy...
This is the seventh post in the blog series „Movements and Institutions“.
Social movements challenge systems of rule and thus institutions. They are expressions of the non-identical, the gaps and fissures in today’s world. That’s what makes social movements interesting and relevant for a critical research agenda. Thus, more than applying ready-made concepts to cases, scholars should inquire into the interactions between social movements and institutions as relationships between rule and resistance. This article proposes one way to go about such a critical research agenda.
This is the eighth post in the blog series „Movements and Institutions“.
Occupy Wall Street has disappeared from the public radar, yet it is worth a second look. Through its structure and identity, it has probably become the United States’ first post-modern movement. Outside of formal institutions, people created their own utopian spaces in the hope for political and social innovation.
This is the sixth post in the blog series „Movements and Institutions“.
How is it that the actions of institutions come to be perceived as unjust by a critical mass? And how does this perception translate into collective action? Adopting a framing perspective, this article proposes to investigate the meanings that people attach to specific events as key for understanding interaction dynamics between social movement and institutions.
Mehr Geld für BND und Verfassungsschutz, bessere Vernetzung der europäischen Datenbanken, die Schaffung eines Ein- und Ausreiseregisters, die Übermittlung von europäischen Fluggastdaten an die Sicherheitsbehörden der EU-Mitgliedsstaaten, mehr Videoüberwachung, Kennzeichenlesesysteme, Biometrie – und vieles mehr. Detaillierte Angaben dazu, ob die angepeilten Maßnahmen überhaupt wirksam sind, werden selten gegeben. Politische Entscheidungsträger denken sich in der Regel nicht selbst aus, was gebraucht wird, vielmehr werden von den Sicherheitsbehörden Bedarfe angemeldet, die ihrer Arbeitslogik entsprechen. Und die sagt im Zweifelsfall: mehr hilft mehr. So sind im Zuge der Bekämpfung des Terrorismus im Laufe der letzten 15 Jahre unzählige verdachtsabhängige und verdachtsunabhängige Maßnahmen ergriffen worden. Allein auf Ebene der EU waren es mehr als 250...
U radu se analiziraju germanizmi u nekoliko izdanja Rječnika stranih riječi Bratoljuba Klaića s nekoliko gledišta: a) što se uopće smatra germanizmom i tako označuje; b) donose li se i označuju li se kao germanizmi i unutarjezične tvorenice motivirane germanizmima te donose li se kao zasebne natuknice ili unutar tvorbenih gnijezda; c) teži li se pri donošenju etimoloških odrednica preciznosti s obzirom na dijatopijsku i dijastratsku raslojenost germanizama; d) koliko su germanizmi zastupljeni u pojedinim izdanjima rječnika.
Dragutin Antun Parčić svojim nam je leksikografskim opusom u trajno nasljeđe ostavio niz dvojezičnih rječnika, talijansko-hrvatskih i hrvatsko-talijanskih, od kojih je Rječnik hrvatsko-talijanski, tiskan 1901. godine, svakako kruna njegova leksikografskoga rada. Iako bogat izvor nazivlja, rječnik je do danas nedovoljno istražen. Cilj je ovoga rada usporediti pomorsko nazivlje koje Parčić donosi u svome rječniku s pomorskim nazivljem koje pola stoljeća kasnije Adolf Bratoljub Klaić zapisuje u Rječniku stranih riječi. Analiza suvremenoga pomorskog nazivoslovlja pokazuje da su noštromizmi, tj. hrvatskome jeziku prilagođeni pomorski nazivi mediteranskoga, uglavnom talijanskoga porijekla, u uzusnoj uporabi, dok je u normativnoj literaturi prednost dana hrvatskome nazivlju. Uzusno je strukovno nazivlje zabilježeno u suvremenim hrvatskim pomorskim rječnicima i rječnicima stranih riječi, a osim noštromizama zapisanih u rječnicima iz 19. stoljeća uvodi se novo nazivlje pod utjecajem engleskoga kao međunarodnoga jezika prometa i pomorstva. U radu se osim u Klaićevu i Parčićevu rječniku propituju zapisi pomorskih leksikografa iz 19. stoljeća.
U radu se analizira fonološko nazivlje koje se upotrebljava u pravopisima kojima je Klaić bio autor. Nazivlje se uspoređuje s fonološkim nazivljem koje se upotrebljavalo u pravopisima koji su prethodili Klaićevim i u onima koji su napisani nakon Klaićevih. Posebna je pozornost posvećena problemu glasovnih promjena. Utvrđuje se koje se glasovne promjene spominju, koji se nazivi upotrebljavaju te kako se one definiraju.
Metodologija morfonološkoga pravopisa (metodološki postupci u Hrvatskome pravopisu iz 1944. godine)
(2014)
U Hrvatskome pravopisu iz 1944. godine, nastalome u Uredu za hrvatski jezik, stoji da su ga sastavili članovi Ureda Franjo Cipra i Adolf Bratoljub Klaić uz suradnju drugih članova. Riječ je o jedinome hrvatskom pravopisnom priručniku u potpunosti zasnovanu na morfonološkome pravopisnom načelu koji je bio službeno propisan (na temelju odluke Ministarstva narodne prosvjete 3. studenoga 1943). Kako ta pravopisna knjiga predstavlja prekid s dotadašnjim smjerom razvoja hrvatske suvremene pravopisne norme kao pretežito fonološke (tj. fonološkomorfonološke), zanimljivo je razmotriti metodologiju njezina sastavljanja. U tome se smislu u analizu uključuju tri aspekta: određenje dosega pravopisne relevantnosti (opseg pojedinačnih problema uvrštenih u pravopisne teme), oblikovanje pojedinih pravopisnih pravila (metajezik pravopisa, tj. kako se u pravopisnoj knjizi gradi popularnoznanstveni diskurs kojim se želi komunicirati s korisnikom) i struktura pravopisne knjige (razina obrade pojedinoga pravopisnog problema: obrada u poglavljima, rječniku, dodacima i sl.). Uz pogled u metodologiju sastavljanja ovoga Pravopisa – knjige koja, zanimljivo, nema ni predgovor ni pogovor – razmotrit će se i njegove poveznice s drugim hrvatskim pravopisnim knjigama.
U radu se daje prikaz tehničkih odnosno strojarskih naziva u prvim četirima izdanjima Rječnika stranih riječi koje je sastavio i priredio sâm Klaić. Analiza uključuje način definiranja pojma, leksikografsku obradu rječničkoga članka kao i osvrt na dopunjavanje novim natuknicama u svakome od četiriju izdanja Rječnika. U radu se donose i primjeri strojarskih germanizama kako su popisani u Klaićevu Rječniku te osvrt na kratice i pokrate kao važno obilježje tehničkoga jezika.
Background: Ovarian cancer is mostly associated with pathologically regulated permeability of peritoneal vessels, leading to ascites. Here, we investigated the molecular regulation of endothelial permeability by the vascular endothelial growth factor (VEGF) and both tight and adherens junction proteins (VE-cadherin and claudin 5) with regards to the tumor biology of different ovarian cancer types.
Methods: Serum and ascites samples before and after surgery, as well as peritoneal biopsies of 68 ovarian cancer patients and 20 healthy controls were collected. In serum and ascites VEGF protein was measured by ELISA. In peritoneal biopsies co-localization of VE-cadherin and claudin 5 was investigated using immunohistochemical dual staining. In addition, the gene expression of VE-cadherin and claudin 5 was quantified by Real-time PCR. Differences in VEGF levels, VE-cadherin and claudin 5 gene expression were analyzed in relation to various tumor characteristics (tumor stage, grading, histological subtypes, resection status after surgery) and then compared to controls. Furthermore, human primary ovarian cancer cells were co-cultured with human umbilical vein endothelial cells (HUVEC) and changes in VE-cadherin and claudin 5 were investigated after VEGF inhibition.
Results: VEGF was significantly increased in tumor patients in comparison to controls and accumulates in ascites. The highest VEGF levels were found in patients diagnosed with advanced tumor stages, with tumors of poor differentiation, or in the group of solid / cystic-solid tumors. Patients with residual tumor after operation showed significantly higher levels of VEGF both before and after surgery as compared to tumor-free resected patients. Results of an immunohistochemical double-staining experiment indicated co-localization of VE-cadherin and claudin 5 in the peritoneal vasculature. Compared to controls, expression of VE-cadherin and claudin 5 was significantly suppressed in peritoneal vessels of tumor patients, but there were no significant differences regarding VE-cadherin and claudin 5 expression in relation to different tumor characteristics. A significant positive correlation was found between VE-cadherin and claudin 5 expression. VEGF inhibition in vitro was associated with significant increase in VE-cadherin and claudin 5.
Conclusions: Our results indicate that increased peritoneal permeability in ovarian cancer is due to down-regulation of adhesion proteins via tumor derived VEGF. Advanced ovarian cancer with aggressive tumor biology may be associated with early dysregulation of vascular permeability leading to ascites. These patients may benefit from therapeutic VEGF inhibition.
U radu se analizira Klaićev Rječnik stranih riječi iz 1983. godine koji je priredio Željko Klaić, sin Bratoljuba Klaića, i koji je izdan u godini smrti Bratoljuba Klaića i Novi rječnik stranih riječi iz 2012. godine koji potpisuju Bratoljub Klaić i Školska knjiga. Analiza se temelji na rječničkim člancima natuknica koje nose terminološke oznake gram., lingv. i fon. Posebna se pozornost posvećuje ustroju rječničkoga članka, definicijama koje se uz te natuknice donose te donošenju istoznačnica. Analizira se glasovno nazivlje, padežno nazivlje, pravopisno nazivlje te nazivlje jezikoslovnih grana, disciplina i pristupa.