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Robustness, validity, and significance of the ECB's asset quality review and stress test exercise
(2014)
As we are moving toward a eurozone banking union, the European Central Bank (ECB) is going to take over the regulatory oversight of 128 banks in November 2014. To that end, the ECB conducted a comprehensive assessment of these banks, which included an asset quality review (AQR) and a stress test. The fundamental question is how accurately will the financial condition of these banks have been assessed by the ECB when it commences its regulatory oversight? And, can the comprehensive assessment lead to a full repair of banks’ balance sheets so that the ECB takes over financially sound banks and is the necessary regulation in place to facilitate this? Overall, the evidence presented in this paper based on the design of the comprehensive assessment as well as own stress test exercises suggest that the ECB’s assessment might not comprehensively deal with the problems in the financial sector and risks may remain that will pose substantial threats to financial stability in the eurozone.
The endemic Floridian milliped genus, Floridobolus Causey, 1957, more closely related to tylobolinines in the western United States (US), Mexico, and Guatemala than syntopic spirobolines, is incorporated into Spirobolidae (Spirobolida: Spirobolidea). With taxonomic priority by one year, its monotypic family is reduced to Floridobolinae, n. stat., comprising Floridobolini and Tylobolini, n. stats., the counterpart to Spirobolinae, comprising Spirobolini and Aztecolini, n. tribe; relationships are Floridobolini + (Tylobolini + (Aztecolini + Spirobolini)). Like F. penneri Causey, 1957, 208 km (130 mi) to the south in the Lake Wales Ridge, Polk and Highlands counties (cos.), F. orini n. sp., inhabits “Big Scrub” environments in the Ocala National Forest, Marion Co. Biogeographic reconstructions, compatible with broader hypotheses on the class’ evolutionary history, indicate that, from a presumptive source area in northern Mexico where the subfamilies overlap, spirobolid stock penetrated the “proto-US” four times, once per tribe, before the Western Interior Seaway developed in the Cretaceous Period, Mesozoic Era. Three expansions headed northeastward into future “Appalachia,” from which taxa spread southward as the Seaway receded. Floridobolini, the fi rst invader, had to be in “proto-Georgia” and positioned to penetrate Florida when the sand dunes that comprise the “Central Highlands” emerged from the sea in the Oligocene (Cenozoic), ~25 mya. As sea levels rose and fell, the dunes fragmented into islands and the subcontinuous Floridobolus population was partitioned. The southernmost became F. penneri; F. orini inhabited a northern island; and a graduate student is investigating other insular remnants for additional species. Shortly after Floridobolini began spreading, Hiltonius/ Tylobolini arose and expanded both southward to Guatemala and northwestward to California; Tylobolus Cook, 1904, diverged in the latter area and dispersed northward to Washington and eastward to Utah/Arizona. The third invader, and the second to disperse northeastward, was Aztecolini, which probably eradicated Floridobolini from some of its established range and was partitioned into Mexican (Aztecolus Chamberlin, 1943) and US (Chicobolus Chamberlin, 1947) taxa by the Seaway. The fi nal invader, Spirobolini, dispersed northwestward and northeastward to both the Pacifi c and Atlantic coasts; instead of Trans-Beringia, we prefer penetration of the Asian part of “Asiamerica,” when it temporarily formed during the Cretaceous, to explain the Mongolian fossil genus, Gobiulus Dzik, 1975, herein assigned to Tylobolini, and the occurrence of Spirobolus Brandt, 1833, in China and Taiwan today. In the east, Narceus Rafi nesque, 1820, spread across Appalachia, eradicated most remaining populations of Floridobolus and Chicobolus, and expanded to Maine and Québec after retreat of the Wisconsin glaciation. Chicobolus and Narceus also penetrated earliest Florida; the former established itself in the Central Highlands, spread through the widening peninsula as sea levels fell, and remained on insular refugia when waters rose. Apparently fueled by the different Floridian environments, Narceus underwent time-consuming speciation; consequently, Floridobolus and Chicobolus still survive on the peninsula, and an allopatric population of the latter inhabits coastal South Carolina. However, N. gordanus (Chamberlin, 1943) occurs syntopically with both in peninsular Florida and may be actively eradicating them from their last stronghold. Trigoniulus niger, takahasii, and segmentatus, all by Takakuwa, 1940, are removed from Spirobolidae and returned toTrigoniulidae (Trigoniulidea). New records in the Appendix include the fi rst of Aztecolus from Durango and Jalisco, Mexico.
Tynommatidae, n. stat., elevated from Tynommatinae, is established as a schizopetalidean family encompassing the western North American callipodidans previously assigned to the Mediterranean Schizopetalidae. It is considered a valid taxon despite somewhat anatomically dissimilar subfamilies, and Colactidinae, Texophoninae, Diactidinae, and Aspidiophoninae constitute tribal elevations and additional new statuses. With a subbasal telopodal prefemoral process, Diactis hedini, n. sp., requires rediagnoses of all three diactidine genera, Diactis Loomis, 1937, and Florea and Caliactis, both by Shelley, 1996, and suggests that telopodal branches ‘B’ in congeners and Florea represent distal relocations of the process along the stem. Similarities in the sizes and shapes of the pleurotergal carinae suggest a sister-group relationship with the other, and partly sympatric, New World family, Abacionidae, which is supported by gonopodal similarities between Colactidinae and Abacion Rafi nesque, 1820. The Western Interior Seaway of the Cretaceous Period, Mesozoic Era, ~141–66 million years ago, appears to have fueled divergence by isolating “proto-abacionid stock” in “Appalachia,” the Eastern North American land mass, which has subsequently spread well into previously inundated areas. The allopatric position of Texophoninae, on the Gulf Coast of south Texas around 1,136 km (710 mi) east of the most proximate familial records, is attributed to this waterway, which eradicated faunal linkages with “proto-Tynommatidae” in “Laramidia,” the Western North American land mass. Texophoninae probably survived the Cretaceous on insular refugia; however, it is rarely encountered anymore and seems destined for imminent extinction. Representatives of the east-Asian families, Caspiopetalidae, Paracortinidae, and Sinocallipodidae, also possess demarcated pleurotergal crests and, implausible though it seems, may share ancestry with the North American taxa vis-à-vis the “Asiamerica” and or “Boreotropic” concepts.
An adventive female Julidae (Julida), discovered in a moist, grassy depression in the Peninsula de Brunswick south of Punta Arenas, Chile, and assigned to Cylindroiulus Verhoeff, 1894, is the fi rst vouchered milliped from southern Patagonia. The southernmost milliped ever collected in Chile, South America, and the Western Hemisphere, it may also constitute the southernmost in the world as the site is only ~1,176 km (735 mi) northwest of the Antarctic Peninsula. Records are consolidated of the two families, three genera, and fi ve species of this Holarctic order that are known from South America. They are documented from Argentina, Chile, and southern Peru and Brazil; three species are known from the Juan Fernandez Islands.
Past concepts and synonymies of Anadenobolus monilicornis (Porat, 1876) (Spirobolida: Rhinocricidae), including the implied synonymy of Rhinocricus ectus Chamberlin, 1920, are consolidated into a formal account with the fi rst illustrations of the holotype. Prior to 1492, A. monilicornis was probably indigenous to an unknown number of southern Antillean islands, but through modern commerce, man has introduced it to Florida, Bermuda, Barbados, the Cayman Islands, and Jamaica, and probably repeatedly (re)introduced conspecifi c material to all the Lesser Antilles, resulting in subcontinuous gene pool mixing and reticulate evolution. A broad species concept is necessary to encompass the multitudinous variants, some of which have been recognized as species; only one true Caribbean species of Anadenobolus Silvestri, 1897, may exist, for which arboreus (Saussure, 1859) is the oldest name. The distribution of A. monilicornis presently extends from Bermuda and southern coastal Florida through the Greater and Lesser Antilles (excepting Cuba) to eastern coastal Venezuela and central Suriname, with outlier populations in Jamaica, the Cayman Islands, and Tampa Bay and the eastern Floridian panhandle; excepting Barbados, the indigenous range may have extended from Hispaniola through the same area. Introductions into Manitoba, Canada, and North Carolina, USA, have not yielded viable populations. Localities are newly recorded from St. Thomas, US Virgin Islands.
A summary of the milliped faunas of Pakistan, Bangladesh, and Kashmir (Arthropoda: Diplopoda)
(2014)
Three female callipodidan samples from northern Pakistan are assigned to Bollmania kohalana (Attems, 1936) (Caspiopetalidae), the only ordinal representative documented from the country; a new record of Kaschmiriosoma loebli Jeekel, 2003 (Polydesmida: Paradoxosomatidae), is also provided. Localities are summarized for the 14 Pakistani, 6 Kashmirian, and 5 Bangladeshi diplopods. The last include one unidentifi able female of Zephronia Gray, 1832 (Sphaerotheriida: Zephroniidae), and two adventive species, Trachyjulus calvus (Pocock, 1893) (Spirostreptida: Cambalopsidae) and Asiomorpha coarctata (Saussure, 1860) (Polydesmida: Paradoxosomatidae); all constitute new country records. Two obscurely documented Bangladeshi diplopods are Gonoplectus cautus (Attems, 1936) (Spirostreptida: Harpagophoridae), and Trichopeltis watsoni Pocock, 1895 (Polydesmida: Cryptodesmidae). The Pakistani polydesmidan, Quasidesmus puschtun Golovatch, 1991, is transferred from Pyrgodesmidae to Cryptodesmidae.
Characterized by small body size, apically rounded/lobed anterior gonopod telopodites, long slender posterior gonopod telopodites, and torsion in the cyphopod receptacles, Floridobolus fl oydi, n. sp., is described from the southern sector of the Brooksville Ridge in northwestern peninsular Florida. It inhabits sandy “Big Scrub” environments like F. penneri Causey, 1957, and F. orini Shelley, 2014, and is documented from the sector’s center and northern periphery, in Hernando and Citrus Counties, respectively, with a sight record from the eastern periphery. Its discovery supports the thesis that each sand ridge in peninsular Florida may harbor a unique species of this endemic genus.
A newly discovered population of Xystocheir brachymacris Shelley, 1996 (Polydesmida: Xystodesmidae: Xystocheirini), in Placer County (Co.), California, exhibits an unusual grayish-black color dorsally with mottled, ovoid patches at paranotal bases; it cons titutes northern generic and specifi c range extensions of ~28.4 km (17.6 mi). The gonopods differ from those in the El Dorado Co. population in having shorter/acuminate prefemoral processes and blade-like, rather than spatulate, processes “B” that angle away from the solenomere instead of overhanging it. Additionally, a strong distomedial prefemoral lobe, absent from the El Dorado population, arises from the stem in Placer Co. males. Authorship of Xystocheirini is properly attributed to Hoffman, 1980.
If we take Benjamin's definitions to their logical conclusion, then the monad and the reproduced copy are set unequivocally into binary opposition, as we, the masses capable and most needful of action, are implicitly denied the potential for liberation through aesthetic experience. This denial could not have been his long-term intention. When we take into account the breadth of his writings in response to Fascism, and we look at the artistic movements, Dada in particular, that Benjamin defines as 'politicizing art,' it seems as though we risk too narrow a reading of Benjamin's theories by assuming the aura can be, or must be, done away with. Rather, I would argue that this moment of auratic interaction is crucial to effectively politicizing art at all. Mechanically-produced art, in order to function politically, must allow its audience the space necessary to step back, awaken their 'Geistesgegenwart', and take action 'before' the present moment is finished and past. The elimination of aura - as per Benjamin’s own definitions of aura - neuters the interaction this awakening requires. While Benjamin provides the framework and asks the right questions, when determining what will allow his definitions to realize their aims most fully, I submit that he draws his line in the wrong place.
The flourishing of literature and thought during the age of Goethe may have inspired German nationalism in the 1930s, but Walter Benjamin identified other values in the period worth defending. 'Deutsche Menschen' is a short collection of edited letters by well-known German authors which Benjamin published in 1936 under the pseudonym Detlef Holz in order to hide his Jewish identity. In his inscription to Scholem's copy of the book, Benjamin wrote, "May you, Gerhard, find a chamber in this ark - which I built when the Fascist flood started to rise - for the memories of your youth," and in his sister’s copy Benjamin wrote, "This ark, built after a Jewish model, for Dora - From Walter." This essay considers what Benjamin may have meant by those inscriptions. Looking beyond discussions of "German," "Jewish," and even "German-Jewish" identity, this essay explores Benjamin's descriptions of his letter collection, asking how he conceptualized and framed it at first and how it may have changed between 1931 and 1936. The categories of tradition and agency will be my focus, which I will develop in the context of Benjamin's other writings and his particular interests in quotation and materialism. &e formation and reception of 'Deutsche Menschen' reveal a complex, ambitious project that combines many of Benjamin's ideas and goals.
Walter Benjamin had a revealing fascination with the legend of a Chinese artist who entered his painting and disappeared in it. In his writings this character becomes an emblematic figure that enables the philosopher to discuss the nature of representation in its various infections (in games and in painting, in theater and in cinema); to explore the status of the image and of the threshold that simultaneously separates and connects image and reality; to analyse the different bodily (i. e. "aesthetic") attitudes of the beholder in his/her close or distant relationship to the image; to investigate the manifold implications of empathy ('Einfühlung ') toward the figurative world; and finally, to approach a peculiar kind of dialectics, namely the "Chinese". My paper aims at considering such varied aspects in Benjamin's interpretation of the Chinese painter, understanding it as a true "dialectical image" that in its 'non-coincidentia oppositorum' provokes not only significant hermeneutic oscillations, but even a radical inversion of its fundamental meaning.
To explicate what distinguishes pain, Benjamin elaborates: "Of all corporeal feelings, pain alone is like a navigable river which never dries up and which leads man down to the sea. [...] Pain [...] is a link between worlds. This is why organic pleasure is intermittent, whereas pain can be permanent. This comparison of pleasure and pain explains why the cause of pain is irrelevant for the understanding of man's nature, whereas the source of his greatest pleasure is extremely important. For every pain, even the most trivial one, can lead upward to the highest religious suffering, whereas pleasure is not capable of any enhancement, and owes any nobility it possesses to the grace of its birth - that is to say, its source. (SW I, 397)" In these important lines, pain's unique strength is linked not to its origin (this is reserved for pleasure), but rather to the way that its strenuous flow throughout the suffering body has the power to lead it to infinite heights. In contrast to pleasure, which is forever seeking out its sources, pain manifests itself most consummately when it is intensified; it fulfills itself most deeply by gradually reenforcing its own fortitude. To make sense of pain, therefore, we must understand the nature of its 'movement': and in Benjamin's metaphor of the "navigable river" - its flow. In what follows, I develop Benjamin's idea of the nature of pain as manifested in the internal law of its ,ow in two other of Benjamin's texts: 'Berlin Childhood Around 1900' (1934) and 'Thought Figures' (1933).
One of the cruxes of Walter Benjamin’s work is the tension between an indebting and an expiating "memoria", i. e. the afflicting and the salvific insistence of history within the present moment. On the one hand, memory inscribes itself onto spaces and bodies in the violent and painful fashion of Kafka's "Penal Colony" apparatus. On the other hand, it can, in the form of rememoration ('Eingedenken'), sublate these very inscriptions. This sublation usually involves some form of redemptive, timely (re-)verbalization, but Benjamin’s conception of it varies. To gain a better insight into this inherent, varying tension, the article will take a closer look at the connection between pain, memory and law-positing violence in some Benjaminian texts, occasionally relating them to the historical background of his discussion.
Scolopendra morsitans L., 1758, is documented from Honolulu, Oahu, Hawaiian Islands, the fi rst record of this anthropochoric chilopod from both the archipelago and state. Hawaii thus becomes the second American state to harbor the species, the other being Florida, where an individual has been taken in Jacksonville, Duval County. Meristic and morphological data are presented for three Hawaiian specimens. At least two other species of Scolopendra, both introduced, occur on these islands: S. polymorpha Wood, 1861, known only from one specimen from Oahu, and one or more representatives of the “S. subspinipes Leach, 1815, complex,” which is widespread and even inhabits Midway Atoll.
Hepatocellular carcinoma (HCC) is the fifth most common malignant tumor and third leading cause of cancer-related death worldwide. Most cases arise as a consequence of underlying liver disease, e.g. developed from chronic hepatitis B or C infectionsalcohol abuse or obesity, and are most often associated with liver cirrhosis. Hypoxiand the hypoxia inducible factors (HIF)-1α and -2α promote tumor progression of HCC, not only affecting tumor cell proliferation and invasion, but also angiogenesis and lymphangiogenesis and thus, increasing the risk of metastasis.
HCC is characterized as one of the most vascularized solid tumors. While HIF-1α and HIF-2α are frequently up-regulated in HCC only HIF-2α is correlated with high patientlethality. HIF-dependent regulation of HCC angiogenesis is controversially discussed.VEGFA, for example, as the most prominent factor inducing tumor angiogenesis represents not only a HIF-1 target, but also a HIF-2 target gene in HCC. This questions whether both isoforms have overlapping functions in regulating the angiogenic switch in HCC.
Besides angiogenesis also tumor-associated lymphangiogenesis significantly influences patient survival in HCC. Lymphatic spread is an important clinical determinant for the prognosis of HCC, but little is known how lymphangiogenesis is controlled in this context. To date, mainly HIF-1α was positively correlated with olymphatic invasion and metastasis in HCC, while a defined role of HIF-2α is missing. Thus, although HIF-1α and HIF-2α are structurally alike and regulate overlapping but not identical sets of target genes, they promote highly divergent outcomes in cancer progression and may even have counteracting roles. The aim of my work was to characterize the specific role of HIF-1α and HIF-2α in the angiogenic switch and lymphangiogenesis induction during HCC development.
Therefore, I created a stable knockdown of HIF-1α and HIF-2α in HepG2 cells and generated cocultures of HepG2 spheroids and embryonic bodies derived from embryonic mouse stem cells as an in vitro tumor model mimicking the cancer microenvironment to analyze which HIF isoform has key regulatory functions in HCC (lymph)angiogenesis. In cocultures with a HIF-2α knockdown angiogenesis was attenuated but lymphangiogenesis increased, while the knockdown of HIF-1α was without effect. Microarray analysis identified plasminogen activator inhibitor 1 (PAI-1)and insulin-like growth factor binding protein 1 (IGFBP1) as HIF-2 target genes.However, prominent angiogenic and lymphangiogenic factors such as VEGFs, PDGFB, ANG and their receptors were not regulated in a HIF-dependent manner. As PAI-1 was linked to angiogenesis in literature and IGF-signaling, which is negatively regulated by IGFBP-1, was correlated with lymphangiogenesis, I decided to investigate their HIF-2α-dependent influence on HCC (lymph)angiogenesis. The knockdown of PAI-1 in HepG2 cells also lowered angiogenesis in PAI-1k/d cocultures similar to the HIF-2α k/d phenotype. PAI-1 as the potent inhibitor of tPA and uPA, both inducing the conversion of plasminogen to plasmin, also inhibits plasmin directly. Therefore, I assumed an increase of plasmin in HIF-2α k/d and PAI-1 k/d cocultures as a result of the reduced PAI-1 levels. Blocking plasmin with aprotinin in HIF-2α k/d cocultures restored angioge nesis, suggesting that HIF-2α increases PAI-1 to lower concentrations of active plasmin, thereby supporting angiogenesis. In further experiments I could exclude PAI-1 to reduce angiogenesis by inducing plasmin-mediated apoptosis of differentiating stem cells in PAI-1 k/d and HIF-2α k/d cocultures, but demonstrated an increase of VEGFA165 degradation in these cocultures, suggesting plasmin-catalyzed proteolysis of VEGF as an additional layer of regulation required to explain the angiogenic phenotype. Besides the pivotal role of PAI-1 in angiogenesis I also investigated its potentialinfluence in lymphangiogenesis. Indeed, the knockdown of PAI-1 reduced lymphaticstructures and implied an important but opposing role in lymphangiogenesis comparedto induced lymphangiogenesis in HIF-2α k/d cocultures. However, blocking plasmin again with aprotinin in HIF-2α k/d cocultures restored lymphangiogenesis to the level of control virus, which indicates a divergent lymphangiogenic role of plasmin in PAI-1 k/d and HIF-2α k/d cocultures, possibly because of other essential pathways masking the lymphangiogenic effects of PAI-1 in HIF-2α k/d cocultures.
HIF-2α resulting in reduced IGFBP1 expression induced the differentiation of stem cells toward a lymphatic cell type and significantly enhanced the assembly of human dermal lymphatic endothelial cells into tubes. These data point the first time to an important impact of HIF-2 in the regulatin of lymphangiogenesis in vitro by inducing IGFBP1 and thus, scavenging IGF-1. Furthermore, matrigel plug assays to investigate the in vivorelevance of these observations confirmed HIF-2α as a crucial factor in the regulation of lymphangiogenesis in vivo
In conclusion, this work provides evidence that HIF-2α is a key regulator of angiogenesis and lymphangiogenesis in HCC by regulating PAI-1 and IGFBP1. HIF-2α positively influences the angiogenic switch via PAI-1 and negatively affects lymphangiogenesis via IGFBP1 expression. Targeting HIF-2α in HCC to reduce tumor angiogenesis should be approached carefully, as it might be overcome by induced lymphangiogenesis and metastasis.
Vasointestinal peptide metabolism plays a key physiological role in multimodular levels of vasodilatory, smooth muscle cell proliferative, parenchymal, and inflammatory lung reactions. In animal studies, vasointestinal peptide relaxes isolated pulmonary arterial segments from several mammalian species in vitro and neutralizes the pulmonary vasoconstrictor effect of endothelin. In some animal models, it reduces pulmonary vascular resistance in vivo and in monocrotaline-induced pulmonary hypertension. A 58-year-old woman presented with dyspnea and mild edema of the lower extremities. A bronchoscopy was performed without any suspicious findings suggesting a central tumor or other infiltrative disease. Endobronchial ultrasound revealed enlarged pulmonary arteries containing thrombi, a few enlarged lymph nodes, and enlarged mediastinal tissue anatomy with suspicion for mediastinal infiltration of a malignant process. We estimated that less than 10% of the peripheral vascular bed of the lung was involved in direct consolidated fibrosis as demonstrated in the left upper lobe apex. Further, direct involvement of fibrosis around the main stems of the pulmonary arteries was assumed to be low from positron emission tomography and magnetic resonance imaging scans. Assuming a positive influence of low-dose radiation, it was not expected that this could have reduced pulmonary vascular resistance by over two thirds of the initial result. However; it was noted that this patient had idiopathic pulmonary arterial hypertension mixed with "acute" (mediastinal) fibrosis which could have contributed to the unexpected success of reduction of pulmonary vascular resistance. To the best of our knowledge, this is the first report of successful treatment of idiopathic pulmonary arterial hypertension, probably as a result of low-dose radiation to the pulmonary arterial main stems. The patient continues to have no specific complaints concerning her idiopathic pulmonary arterial hypertension.
Introduction: Currently there are several advanced guiding techniques for pathoanatomical diagnosis of incidental solitary pulmonary nodules (iSPN): Electromagnetic navigation (EMN) with or without endobronchial ultrasound (EBUS) with miniprobe, transthoracic ultrasound (TTUS) for needle approach to the pleural wall and adjacent lung and computed tomography (CT) -guidance for (seldom if ever used) endobronchial or (common) transthoracical approach. In several situations one technique is not enough for efficient diagnosis, therefore we investigated a new diagnostic technique of endobronchial guided biopsies by a Cone Beam Computertomography (CBCT) called DynaCT (SIEMENS AG Forchheim, Germany). Method and Material: In our study 33 incidental solitary pulmonary nodules (iSPNs) (28 malignant, 5 benign; mean diameter 25 +/-12mm, shortest distance to pleura 25+/-18mm) were eligible according to in- and exclusion criteria. Realtime and onsite navigation were performed according to our standard protocol.22 All iSPN were controlled with a second technique when necessary and clinical feasible in case of unspecific or unexpected histological result. In all cases common guidelines of treatment of different iSPNs were followed in a routine manner. Results: Overall navigational yield (ny) was 91% and diagnostic yield (dy) 70%, dy for all accomplished malignant cases (n=28) was 82%. In the subgroup analysis of the invisible iSPN (n=12, 11 malignant, 1 benign; mean diameter 15+/-3mm) we found an overall dy of 75%. For the first time we describe a significant difference in specifity of biopsy results in regards to the position of the forceps in the 3-dimensional volume (3DV) of the iSPN in the whole sample group. Comparing the specifity of biopsies of a 3D-uncentered but inside the outer one third of an iSPN-3DV with the specifity of biopsies of centered forceps position (meaning the inner two third of an iSPN-3DV) reveals a significant (p=0,0375 McNemar) difference for the size group (>1cm) of 0,9 for centered biopsies vs. 0,3 for uncentered biopsies. Therefore only 3D-centered biopsies should be relied on especially in case of a benign result. Conclusion:The diagnostic yield of DynaCT navigation guided transbronchial biopsies (TBB) only with forceps is at least up to twofold higher than conventional TBB for iSPNs <2cm. The diagnostic yield of DynaCT navigation guided forceps TBB in invisible SPNs is at least in the range of other navigation studies which were performed partly with multiple navigation tools and multiple instruments. For future diagnostic and therapeutic approaches it is so far the only onsite and realtime extrathoracic navigation approach (except for computed tomography (CT)-fluoroscopy) in the bronchoscopy suite which keeps the working channel open. The system purchase represents an important investment for hospitals but it is a multidisciplinary and multinavigational tool with possible access via bronchial airways, transthoracical or vascular approach at the same time and on the same table without the need for an expensive disposable instrument use.
In spring and summer 2008, the Odonata fauna of the Khabr National Park (Iran) was studied for the first time. Here, we present records of the representatives of family Libellulidae only. A total of twelve libellulid Odonata were found. Most of them are common species in Iran and other parts of Kerman province. Scarce Iranian species are Trithemis arteriosa and Zygonyx torridus.
With its broad spectrum of cults and coexisting religions Graeco-Roman antiquity seems, at first glance, to be the embodiment of religious freedom. Yet, a closer analysis shows that a concept of tolerance or the idea of religious freedom did not exist. Political institutions could easily suppress religious practices that were regarded as offensive. Fighting against the oppression of Christians appears to have increased under the influence of oecumenical paganism during the reign of the Severans. In this time, the Christian thinkerTertullian discovered and articulated the concept of religious freedom. However, he did not do so emphatically and the concept was not very successful in antiquity. With the Christianization of the Roman Empire it disappeared soon, although its rediscovery in later epochs contributed heavily to the formation of the European norm of religious freedom.
Smac (second mitochondria-derived activator of caspase) mimetics are considered as promising anticancer therapeutics and used to induce apoptosis by antagonizing inhibitor of apoptosis proteins, which are often abundantly expressed in cancer cells. Here, we identify interferon regulatory factor 1 (IRF1) as a novel critical regulator of Smac mimetic BV6-induced apoptosis and proinflammatory cytokine secretion with impact on the immune response. IRF1 knockdown rescues cells from BV6-induced apoptosis and attenuates BV6-stimulated upregulation of tumor necrosis factor-α (TNFα), indicating that IRF1 mediates BV6-triggered cell death, at least in part, by inducing TNFα. This notion is supported by data showing that exogenous supply of TNFα restores BV6-induced cell death in IRF-knockdown cells. Interestingly, IRF1 selectively controls the induction of nuclear factor-κB (NF-κB) target genes, as IRF1 depletion attenuates BV6-stimulated upregulation of TNFα and interleukin-8 (IL-8) but not p100 and RelB. Concomitant knockdown of IRF1 and p65 cooperate to inhibit BV6-induced cell death, implying a cooperative interaction of IRF1 and NF-κB. In addition, IRF1 silencing hampers TNFα induction by TNFα itself as an another prototypical NF-κB stimulus. Importantly, IRF1 depletion impedes BV6-stimulated secretion of additional proinflammatory cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-8, IL-6 and monocyte chemoattractant protein-1, and migration of primary monocytes to BV6-treated tumor cells. In conclusion, this identification of IRF1 as a dual regulator of BV6-induced apoptosis and inflammatory cytokine secretion provides novel insights into determinants of sensitivity towards Smac mimetic and possible implications of Smac mimetic treatment on tumor microenvironment and immune response.
The publication is the latest in the African Studies in Russia series of compilations and contains full articles and annotations of the most important - from the point of view of editors - works of Russian Africanists over a certain period. The authors work at the Institute for African Studies of the Russian Academy of Sciences (RAS). The present issue covers the years 2010 to 2013 and consists of two sections. The first section presents conceptual articles on Africa published in authoritative journals. The second section offers synopses of books by Russian authors on economics, cultural anthropology, social and political development, gender studies, and international relations of African countries. The main objective of the triennial series of compilations is to introduce new findings of Russian Africanists to interested foreign scholars who do not speak Russian.
Acacia
(2014)
Acacia is a strong and independent woman whose heart and heritage like rooted in Africa, while her reality in contemporary America finds itself in a very different time and place. In living her life, she must breach the distance between her current space and the ties that bind her. Straddling two sometimes opposing worlds of medicine and dance, Dr Acacia Graeme must find the balance between feeding her mind through work and study, and nourishing her soul and spirit through dance. And what happened when the music stops? Because it does, often. How will she get through the silence of her every day? This is the story of a flawed heroine whose intentions are pure, her truth perhaps less so. Torn between the enduring innocence of her first love and the life-long search that is her longing for one true love, she is compelled to come to terms with her own free nature and independent spirit and, in so doing, turn tragedy to triumph.
Bless me Father
(2014)
Bless Me Father is the true story of an incredible South African life. Born into a violent and broken family, and growing up in a variety of institutions, Cape Town based poet and writer Mario d'Offizi tells his remarkable, often shocking and ultimately inspiring life adventure - one that spans several decades in a country undergoing radical change. From his tough days at Boys Town to wild years in the advertising world, a stint in the restaurant business and a sharp edged journalistic adventure in the DRC, d'Offizi tells his critically acclaimed story with the unfailing sensitivity and warmth of a true poet.
Customary Law Ascertained Volume 2 is the second of a three volume series in which traditional authorities in Namibia present the customary laws of their communities. It contains the laws of the Bakgalagari, the Batswana ba Namibia and the Damara communities. The recognised traditional authorities in Namibia are expected to ascertain the customary law applicable in their respective communities and to note the most important aspects of the laws in written form. The Ministry of Regional and Local Government, Housing and Rural Development, and the Council of Traditional Leaders therefore initiated the ascertainment of customary law. The ascertainment project is housed in the Human Rights and Documentation Centre of the University of Namibia. The former Dean of the Faculty of Law of the University of Namibia, Professor Manfred O. Hinz, has directed the project since its inception.
This study raises awareness to the emergence of a new genre in world literature?hybridized literature. It rejects the assumption according to which literatures written in less commonly taught languages should be subsumed into one universally accessible global idiom. Instead, Vakunta challenges literary scholars and readers of literature to regard untranslatability as the key to cross-cultural engagement. The book?s multiple approaches and innumerable sources generate complex interdisciplinary connections and provide an excellent introduction to a complex literary phenomenon alien to literati resident outside the officially bilingual multicultural and multilingual Republic of Cameroon.
African Cultures, Memory and Space is an impeccable volume that powerfully grapples with a gamut of cultural heritage issues, challenges and problems from a vista of inter- and multi-disciplinary approach. The book, which is designed as a foundational text to the study of culture in ever-changing environments, makes an important argument that the dynamism of culture in highly globalised societies such as that of Zimbabwe can be studied from any perspective, but most importantly through careful examination of cultural elements such as memory, oral history and space, among others. While the book makes special reference to Zimbabwe, it profoundly and audaciously dissect and cut across different geographical and cultural spaces through its penetrating interrogation and scrutiny of different issues commonplace in many African contexts and even beyond. The book, written by scholars from different backgrounds and orientations, should appeal to scholars, researchers and students from various disciplines which include but not limited to Cultural Heritage Studies, Policy Studies, Social-Cultural Anthropology, Sociology, Development Studies and African Studies.
This book is about home. With Malawi as its focus, it seeks to understand ideas about home as expressed through poetry written by Malawians in English. Although African Literatures are studied those of Malawi have not received agreeable attention. This book surveys poetry by five Malawian writers - Felix Mnthali, Frank Chipasula, Jack Mapanje, Lupenga Mphande, and Steve Chimombo. The discussion negotiates scribed experience of exile, engendered by Dr. Banda's regime, and shows that the selected poets effectively converse with a sense of home, reflecting on its transformations in their work. Interrogating the strict definitions of home, the argument highlights that far from home-less exiles in fact clarify the sense of what 'home' is. The manoeuvre is one of thinking towards an unboundaried 'home'. This book will be of value not only to readers interested in the cultures of Africa but to all those with an interest in worldwide literary phenomena, and ideas therein of home and exile.
Elizabeth Stirredge's spiritual autobiography is a treasury of spiritual wisdom which paints all that which is needed to be a faithful servant of the Lord Jesus Christ and how God in His might works, transforms, and supports an ordinary soul to lead the life of extraordinary faithfulness. The text highlights Stirredge's intimate conviction as well as that of early Quakers. This translation is a welcomed venture because this is a central piece, deserving of much more attention than that which has been accorded to it until now.
Faith conversion experiences are first of all personal before being universal. While biblical history records relatively few conversion encounters as dramatic and as explosive as Saint Paul's on the road to Damascus, it is not rare for individuals in the throes of a religious conversion to fall prey to intensely agonizing confusion. That is what happened to Martin Jumbam when he marched for peace in his country alongside the charismatic and irrepressible Emeritus Archbishop of Douala in Cameroon, Christian Cardinal Tumi. He joined the prelate as a secular journalist but went back home more than ever conscious of his state as a fallen Christian, the first step in his journey of faith. Since then, all his writing, be it secular or religious, now bears the fruits of that encounter, characterized by intense empathy for the human person. This book recounts the myriad ways Jumbam's encounters with Christian Cardinal Tumi have activated, nourished and inspired his faith.
This book is an ethnographic study of a group of migrants in Cape Town from Malawi, Zimbabwe and South Africa. It seeks to understand how migrants overcome structural exclusion by forming and maintaining convivial relationships through the Bay Community Church and how this is facilitated by Information and Communication Technologies (ICTs). The book argues that ICTs are implicated in the negotiation of conviviality. ICTs allow for a negotiation of intimacy and distance; although their functions may facilitate more contact than is desired or further distance those already separated physically. This book interrogates the strict division between 'insiders' and 'outsiders' and highlights that migrants are able to sustain multiple networks and relationships, linking their home and host countries. Despite increasingly strict border control and animosity from host communities, migrants are able to overcome imposed identities such as 'outsider'. They do so by using ICTs such as cell phones and Facebook to emphasise their Christian identity, which is one of the main factors for inclusion in church-based networks. Membership with a mixed denominational church such as the Bay further challenges the notion that migrants stick to themselves. Inclusive communities such as the Bay and everyday desires for conviviality evoke the need to reconsider policies too narrowly articulated around the dichotomisation of 'foreigners' and 'nationals', 'home' and 'away', 'us' and 'them'.
Day and Night in Limbo
(2014)
With humour, insight and irony, Lonkog recounts the joys and contradictions of daily life in a Northern Cameroon village. Living in Carrefour Poli in Northern Cameroon was never easy. How far will one have to go for drinking water during the dry season? Will there be money for kerosene to fill the lamp tank? For batteries for the torch? For a bowl of corn to make 'fufu' for the family? Will there be a night encounter with the poison of a snake or scorpion? The man of Carrefour Poli imagines when he last had a bottle of beer and when he will next have another. Children sit in class staring at the teacher, while their work suffers. People sit under trees for shade only to cut them down for firewood. Ministers run up and down, working very hard and sweating, but little changes. Day and night people turn around on the same spot. It takes a long time to build a nation. Everything is in limbo.
Touring Girls
(2014)
Touring Girls tells the story of Jacob Mbuy a young Cameroonian whose primary objective in life is having affairs with as many women as possible. He is obsessed with abusing young girls as well as instilling hopeless hope in adult women. His demise comes when he changes his world from the Christian to the Moslem world where he confronts a new type of women who behave strangely and cannot dance to his tunes. Protected by Islamic traditions and strict government laws, Jacob lands into a hell of unprecedented problems.
Building on Fossungu's earlier works, and essentially providing Africa with original, critical, and multi-level analyses of the trio of globalization, democracy, and national determination, this book theorizes that African states have to unite in order to have any impact in the global economy. Using the failure of the Cameroon Goodwill Association of Montreal (CGAM) as a case study, the book urges Africans to make hard choices and avoid politickerization and midnight politics in favour of fossungupalogy (that is, the science of straightforwardness, necessitating the fearless looking at truth straight in the eye). The questions of the book are many but do all boil down to whether or not Africans fear the truth and do not therefore do politics. It is amazing that Africans in the West live in societies where fierce political competitors do embrace each other after one has defeated the other; but they are incapable of looking their so-called friends in the eye and saying, for example: 'Man, I think you've totally gotten it wrong this time.' Such comportment defines politickerization or negative competition. While attempting some possible responses to the numerous queries it raises, this book basically proffers the science of Four-Eyesism as a discipline that all African schools need to institute and make a compulsory subject: if the vandalized continent would have to be awakened to its realities. This book is rich in Fossungu's dazzling capacity to invent, define and use a multitude of new terminological constructs informed by African experiences.
What does it mean to be marginal? For residents of Cape Town?s Langa Township, being considered marginal is subject to a host of social, physical and sometimes materialistic qualifications ? not least of which is owning a mobile phone. Through various presentations of unique aspects of township life revealed through ethnographic snapshots, this book reveals the complex realities of marginalization experienced by some residents in Langa Township, located in Cape Town, South Africa. Mobile phones have been embraced and accommodated by both local South Africans and African immigrant residents living and working in Langa. Among other things, the technology has become a way of challenging (real and imagined) marginalities within the township in particular and South Africa in general. The book provides empirical data on the role of technology in regards to migration and notions of belonging; specifically the ways that technology has mitigated distance for residents, provided opportunities for development, facilitated the negotiation of various marginalities, and offered new ways of belonging for Langa residents.
Cameroon's Predicaments
(2014)
This book deals with a variety of socio-cultural, economic and political problems facing Cameroon and the rest of Africa, with particular reference to unemployment, corruption, poverty, criminality, violence, insecurity, and moral decadence. It presents a critical analysis of government policies from the colonial era to the present time; arguing that most of these policies have been stalled by an uncommitted leadership. The regime in Cameroon has drifted away from basic managerial and democratic principles in in favour of the ethnicisation of politics, sterile consumption, clientelism and patronage. The book contends that corruption has become the main instrument of governance whereby the political and economic elites control the wealth of the nation at the expense of a majority who wallow in abject poverty and misery. Faced with the difficult economic and political situation, most youth and the intelligentsia have adopted ?official and ?unofficial? means to circumvent all immigration rules to travel to affluent Western countries, the consequences notwithstanding. Brain drain is often the outcome. Further, it examines issues of social exclusion, political representation and marginalization with special focus on the predicament of Anglophone Cameroonians as a socio-cultural community. The inclusion of examples and case studies based on empirical and secondary data from Africa is intended to foreground the importance of comparison, and attract the interest of both academic and non-academic readership.
From his first research there in 1959 until shortly before his death in 2010, Victor Le Vine was a major Cameroon scholar. What he wrote during Cameroon's first half-century of independence carries implications for the years ahead. This volume introduces and presents eight of his short writings, 1961-2007, five never previously published. They demonstrate his mastery of the intricacies and the sweep of the country's governance history, and both his own and Cameroon's importance for African Studies at large.
In Chains for My Country is an account of the struggle of the Southern Cameroons National Council (SCNC), a nonviolent liberation movement, to wrestle British Southern Cameroons from the colonial claws of la République du Cameroun. It is an epic and thrilling account of the life of British Southern Cameroons, which passed from colonial rule to foreign domination through annexation and attempted assimilation into neighbouring la République du Cameroun. Under British trusteeship, British Southern Cameroons graduated to self-government in 1954 with all hopes of independence. Instead, the Trust Territory was doomed to subservience in a contested union with la République du Cameroun. Failure to implement United Nations Resolution 1608 of April 1961 to establish the envisioned federation of two states equal in status facilitated la République du Cameroun's annexation and colonial occupation of a defenseless United Nations Trust as Britain withdrew all its personnel and forces. The territory has been reduced to two provinces of la République du Cameroun under the rule of proconsuls backed by an imperial occupation force with an agenda of nipping in the bud any resistance.
Searching for Bate Besong
(2014)
The future of the country in Searching for Bate Besong is compromised by irresponsible leadership, falsehoods, blind tyranny, waste, and lawlessness. Visionaries like Dockinta (a literary incarnation of Bate Besong, one of Cameroon's most fiery and revolutionary authors) who try to question or expose the status-quo are incarcerated and tortured by the brute forces of dictatorship. It however only needs the strong will and audacity, the messianic self-sacrifice and determination (which are the values Dockinta incarnates), to expose, ridicule and destroy power drunkenness. This play is sine qua non to searching for the collective memory of a community marginalized and subjugated by successive regimes of exploitation and repression. It promises the rediscovery of the dignity and destiny of an active volcano wrongfully rendered docile. The Search will liberate a people who agonized from the whips by the Germans, the hypocrisy of the British, the outright exploitation of the French and the eternal domination of La Republique du Cameroun. The search will culminate in liberating not only Cameroonians, but Africa from corruption, nepotism, tribalism, organized crime, wars and the abuse of basic human rights and freedoms.
The Rising Sun and Boma
(2014)
The Rising Sun and Boma interrogate social evils such as moral decadence, corruption, and greed that are rife in the Cameroonian society. In both plays, Ipah, Paddy, Dinna, and Boma, for example, exemplify how waywardness and avarice can subvert moral integrity. At the same time, the plays problematise the intersection of tradition and modernity, articulating the tension inherent in both visions of life. Although the moral landscape of the drama appears sordid, characters like Abu Ipah and Joseph enkindle hope. Initially performed seventeen years ago, the plays are still as poignant as they are didactic and hilarious as they are refreshing. The characters are credible and compelling partly because of the felicitous language that is anchored in the local imagery.
Before the Rainbow
(2014)
Emmanuel Fru Doh, a native of Cameroon, holds a Ph.D. from the University of Ibadan, Ibadan, Nigeria. He taught at the University of Yaounde (E.N.S. Bambili) for almost a decade-the 90s-before leaving for the US. He then had a brief stint as an Adjunct Professor at the University of Minnesota before settling into the Department of English at Century, a College within the Minnesota State Colleges and Universities (MnSCU) System. Poet, novelist, social and literary critic, Emmanuel Fru Doh is the author of Nomads: The Memoir of a Southern Cameroonian.
Prevalent poverty and related problems in the East African region call for substantial action from various stakeholders, including social workers. This book, based on comprehensive empirical research, portrays an emerging yet powerful profession that has a significant role to play in the endeavour towards social development, social justice, human rights and gender equality. The book is the first of its kind to provide first-hand theoretical and empirical evidence about social work in East Africa.
This book addresses itself to mobilisation and involvement of rural people in development projects. It describes an imperfect but, nonetheless, exciting and thought-provoking exercise that drew social science researchers and students from four public universities in Kenya into an experiment in participatory research, community education and development in two locations. The experiment was grounded on the assumptions that the people of Kenya are a primary resource and that given proper roles and contribution of planners, researchers and programme implementers, self-sustainable development can become a reality. The contributors of this book have focused on the potential of the university to facilitate participation of the people in development. They have given specific suggestions on how this might be accomplished.
African land rights systems
(2014)
This book, from ethical, interdisciplinary, and African perspectives, unveils the root causes of the increasing land disputes. Its significance lies upon the effort of presenting a broad overview founded upon a critical analysis of the existing land-related disputes. It is a perspective that attempts to evaluate the renewed interest in evolving theories of land rights by raising questions that can help us to understand better differences underlying land ownership systems, conflict between customary and statutory land rights systems, and the politics of land reform. Other dimensions explored in the book include the market influence on land-grabbing and challenges accompanying trends of migration, resettlement, and integration. The methodology applied in the study provides a perspective that raises questions intended to identify areas of contention, dispute, and conflict. The study, which could also be categorized as a critical assessment of the African land rights systems, is intended to be a resource for scholars, activists, and organizations working to resolve land-related disputes.
Kpewi Durorp is the third attempt at bringing Durorp into the public domain, and is a more detailed introduction to the language. It contains sixteen chapters which address important elements of grammar, with some including mini bilingual dictionaries, with words organised not alphabetically but thematically, with the singular aim of facilitating learning and easy acquisition of the language. Durorp is an interesting and linguistically distinct semi-Bantu or Bantoid language spoken by a minority group of people known as Bororp or people of the Kororp ethnic group. A part of this ethnic group inhabits the Southwestern part of Cameroon while the other occupies the Southeastern tip of Nigeria. A minority group, Kororp has continued to suffer not only cultural and socio-economic shrinkage but also linguistic marginalisation characterised by an obvious erosion of some key elements of the language. Like any other language, however, Durorp has borrowings from languages such as Efik, Ejagham, and even English. There is a Durorp-English Dictionary to facilitate the development of Durorp vocabulary (Langaa, 2013).
The Clash of the Titans and Other Short Stories is a sundry, marvellous collection of short stories that reflect and capture diverse life experiences. Mabeza and Mawere offer with great dexterousness a snapshot, richness, and practical potentialities of childhood to adulthood experiences in shaping, inspiring and influencing moral rectitude, industriousness and determination. This is an incisive and invigorating exposé steeped in candour and earnestness. For aficionados of creative writing, cognoscenti, students and instructors of English Literature, this is a collection to enjoy and cherish.
Ruminations of Ipome
(2014)
Breadth taking in range of subject explored and profound in depth of emotions evoked, this collection of poems chronicles different shades of emotions resulting from personal loss and love, as well as celebrates and critiques issues of culture, nature, place, people, ethics, and politics. The language is luminous and honed by refreshing and suggestive imagery.
Kids: Africa in Childhood Poetry powerfully conveys the wishful thinking, imaginations, experiences and critical reflections of children as they grow up. The volume grapples with a wide range of topics, sensations, encounters, emotions, imaginations and vistas commonplace in the psyche of many children across different geographical and cultural spaces. While the audacity of Mawere's poetry finds its basis in the poet's profound ability to uncover a multi-layered journey of childhood to adulthood, its merit lies in the character building, psychological, axiological and pedagogical lessons it imparts in today's youths: it teaches the youths the values of moral rectitude, critical observation and thinking, and careful questioning and reflection. This is a collection for all parents, teachers and the youths of between ages 5-18 who cherish a world ruled by peace and unconditional love of all by all.