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Captive of Fate
(2007)
Captive of Fate is the moving story of Ann, a victim of her own need for genuine love, and her gullibility in falling head over heels into the traps of lust set up by clever men. As Ann's biographic narrative unfolds, the reader is faced again and again with the haunting question: 'Do all men want only one thing from a woman?' Hidden between the lines and yet hammering constantly at the reader's conscience are issues pertaining to gender violence and the plight of women in Africa.
This thesis reports three experiments on structural choices during grammatical encoding in monolingual adult speakers of German. Conceptual accessibility, one of the most central notions in language production research, as well as the phenomena of structural and perceptual priming are investigated.
In the first two experiments, a manipulation in terms of inherent conceptual accessibility which has shown universal influences on language production - the factor animacy - is combined with a manipulation making the non-canonical passive structure itself more accessible via structural priming.
Results show that, in addition to a preference for animate entities preceding inanimate entities, speakers can be structurally primed. Structural priming of passive structures led to significantly more passive responses compared to (intransitive) baseline structures.
This holds for monologue settings (Experiment 1) as well as dialogue settings (Experiment 2).
The structural priming effect was stronger in the dialogue setting compared to the monologue setting.
The third experiment combines contexts manipulating the derived conceptual accessibility of one of two entities to be described with a visual cueing manipulation increasing the perceptual accessibility of one of the referents.
Whereas a comprehensive literature review as well as the experimental work conducted within this thesis suggest that animacy and topicalization may exert universal influences on structural choices during language production, perceptual accessibility does not seem to have this potential.
In line with previous cross-linguistic work, perceptual priming in form of an implicit visual cueing manipulation did not show significant effects on speakers' structural choices in German.
These findings contrast with findings obtained for English, suggesting that language-specific characteristics in terms of word order flexibility may influence effcts on grammatical encoding during language production.
Increasing the derived accessibility of one of two referents, however, once again showed significant influences on speakers' structural choices with the topicalization of a patient referent leading to an enhanced production of passive responses.
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative movement disorder caused by expansion of CAG repeats in the ATXN2 gene beyond 33 units, while healthy individuals carry 22-23 repeats. First symptoms of SCA2 include uncoordinated movement, ataxic gait and slowing of the saccadic eye movements in line with the early pronounced atrophy of cerebellum, spinal cord and brainstem. Cerebellar Purkinje cells and spinal cord motor neurons are the most affected cells from ATXN2 expansions. Later on, patients manifest distal amyotrophy, problems in breathing and swallowing, depression and cognitive decline caused by widespread degeneration throughout the brain. The striking loss of mass in the brain, due to severe myelin fat atrophy, is accompanied by a similar reduction in the peripheral fat stores. After the devastating progression of disease, the severity and duration of which depends on the CAG repeat size, genetic background and environmental factors, patients succumb to SCA2 mostly because of respiratory failure at the terminal stage. Larger repeat sizes lead to an earlier manifestation of the disease and a more rapid progression. Aside from SCA2, intermediate-length and short pathogenic CAG expansions in ATXN2 between 26-39 repeats significantly increase the risk of developing other neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), fronto-temporal lobar dementia (FTLD) or Parkinson plus tauopathies like progressive supranuclear palsy (PSP) in various cohorts across the world.
Ataxin-2 (ATXN2) is a ubiquitously expressed cytosolic protein most famous for its involvement in neurodegenerative disease caused by the expanded poly-glutamine (polyQ) domain corresponding to a genomic (CAG)n tract. This N-terminal polyQ domain has no known function, other than increasing the aggregation propensity of mutant ATXN2 and facilitating interaction with other polyQ containing proteins, leading to their sequestration. The progressive accumulation of ATXN2 into cytosolic foci, and also that of its interaction partners over time, underlies the molecular pathomechanism. Next to polyQ domain, ATXN2 also contains a Like-Sm domain (Lsm), an Lsm-associated domain (LsmAD), multiple proline-rich domains (PRD) and a Poly(A)-Binding-Protein (PABP)-interacting motif (PAM2).
Through its Lsm/LsmAD domains, ATXN2 directly binds to a large number of transcripts, regulating their quality and translation rate. In a similar fashion, through its direct interaction with PABP via PAM2 motif, ATXN2 indirectly modifies the fate of even larger number of transcripts and global translation. Several PRDs scattered across the protein help ATXN2 associate with growth factor receptors and other endocytosis factors, modulating nutrient uptake and downstream signaling.
ATXN2 is a stress response factor. Therefore, its involvement in nutrient uptake plays a crucial part in cell’s capability to overcome non-permissive conditions. Upon nutrient deprivation, oxidative stress, proteotoxicity, heat stress or Ca2+ imbalance, ATXN2 relocalizes into cytosolic ribonucleoprotein particles known as stress granules (SGs), together with PABP, several eukaryotic translation initiation factors, many other RNA-binding proteins (RBP) with their target transcripts and the small ribosomal subunit. Collectively, they modulate the stability of the trapped transcripts, favoring the maturation and translation of IRES-dependent stress response proteins instead, according to the specific need. Many RBPs interact either directly or in an RNA-dependent manner in the SGs, and due to the large number of ALS-causing mutations identified in them (such as TDP-43, FUS, TIA-1, hnRNPA2/B1), SGs became a hot topic in neuropathology. Acute SGs serve to halt translation and growth, and to spend energy only for survival until stress disappears. However, chronic SG assembly eventually activates apoptotis leading to cell death. While the polyQ expansions in ATXN2 enhance SG stability, reduce their dissociation rate after stress, and lead to aberrant post-translational modifications of other SG components like TDP-43, complete loss of ATXN2 delays SG formation and results in easily dissolvable foci.
Most of the stressors that induce SG formation eventually converge on energetic deficit. Therefore, it is logical that the ultimate task of SGs is to stop further growth when it cannot be afforded. In yeast, the molecular mechanism underlying this growth arrest was explained as sequestration of the master growth regulator complex, Target-of-Rapamycin Complex 1 (TORC1), into SGs in an ATXN2-dependent manner. The repressor effect of ATXN2 on mammalian TORC1 (mTORC1) and global protein translation had already been documented in earlier studies; complete loss of ATXN2 function in knock-out mouse (Atxn2-KO) resulted in mTORC1 hyperactivity and transcriptional upregulation of multiple ribosomal subunits indicating an increased need for these machines. ...
The Green Cross of Kafira
(2013)
In his last play published posthumously the late Francis Imbuga presents the dramatic dialogue of his characters as mind games. In addition to using a narrator, Sikia Macho, to fill us in on the broken politics of Kafira, centring around detention without trial, Imbuga deliberately delays the inciting action, the formation of the Green Party of Kafira which then challenges the hitherto political monolith called the National Party. The candidate of the new party, former detainee Pastor Mgei, wins the election, and thereby dethrones the so-called Chief of Chiefs. In The Green Cross of Kafira, Imbuga, with a renewed sense of urgency, addresses the theme of dictatorship in Africa, and completes his trilogy of the Kafira plays which begins with Betrayal in the city followed by Man of Kafira.
Mohammed Chris Alli is a retired Nigerian Army Major General who served as Chief of Army Staff from 1993 to 1994 under General Sanni Abacha's regime and was military governor of Plateau State Nigeria from August 1985 to 1986 during the military regime of General Ibrahim Babangida. Many years later, he was appointed interim administrator of the state during a 2004 crisis in the state following ethno-religious killings in Shendam, Yelwa Local Government. In this anthology, organized as a symposium on Mohammed Christopher Alli?s work, he is identified as one of those critical and rational thinkers, philosophers, albeit, a General in the Nigerian Army, whose work finds a befitting logical space in the contemporary African philosophical tapestry. The book also captures the elements of military misrule in Nigeria and its undue influence on the body polity; it is a critical survey of past military misadventures, and a satire against false federalism, it is a firm warning against future corruption and impunity in the military.
This book addresses itself to mobilisation and involvement of rural people in development projects. It describes an imperfect but, nonetheless, exciting and thought-provoking exercise that drew social science researchers and students from four public universities in Kenya into an experiment in participatory research, community education and development in two locations. The experiment was grounded on the assumptions that the people of Kenya are a primary resource and that given proper roles and contribution of planners, researchers and programme implementers, self-sustainable development can become a reality. The contributors of this book have focused on the potential of the university to facilitate participation of the people in development. They have given specific suggestions on how this might be accomplished.
Thousands of Cameroonian women played an essential role in the radically anti-colonial nationalist movement led by the Union of the Populations of Cameroon (UPC): they were the women of the Democratic Union of Cameroonian Women (UDEFEC). Drawing on women nationalists' petitions to the United Nations, one of the largest collections of political documents written by African women during the decolonization era, as well as archival research and oral interviews, this work shows how UDEFEC transcended ethnic, class, education and social divides, and popularized nationalism in both urban and rural areas through the Trust Territories of the Cameroons under French and British administration. Foregrounding issues such as economic autonomy and biological and agricultural fertility, UDEFEC politics wove anti-imperial democracy and notions of universal human rights into locally rooted political cultures and histories. UDEFEC's history sheds light on the essential components of women's successful political mobilization in Africa, and contributes to the discussion of women's involvement in nationalist movements in formerly colonized territories.
Combined together in three volumes are the author's writings on labour and employments relations in Nigeria spanning over three and a half decades. Volume three covers the dynamics of public sector employment relations and starts with a general review and critique of organised labour's perceptions of and contributions to the development crisis in Nigeria.
Professor Darah turned seventy on Wednesday November 22, 2017 and to celebrate his very productive career, his colleagues and many of those he has mentored thought it appropriate to mark his official exit from the university in a dignified way by commissioning for publication, in the now acceptable festschrift tradition, the highly compelling and outstanding collection of essays titled: Scholarship and Commitment: Essays in Honour of G.G. Darah. The book is a ground-breaking collection of essays; some are couched as tributes to the ebullient celebrant, there are others on more serious discourses in the areas of literary theories and criticism, language and linguistics, popular literature and politics, the African woman, identity and contemporary realities, oral literature, the news media and cultural studies. The essays, on their own, attest to the vivacity and liveliness as well as the encouraging state of health of publishing in the Nigerian academia, which in this collection alone, parades forty-two essays in different fields or discourses.
This is a story of Nigeria, told from the inside. After a successful career in the private sector, Nasir El-Rufai rose to the top ranks of Nigeria's political hierarchy, serving first as the privatization czar at the Bureau for Public Enterprises and then as Minister of the Federal Capital Territory of Abuja under former President Olesegun Obasanjo. In this tell-all memoir, El-Rufai reflects on a life in public service to Nigeria, the enormous challenges faced by the country, and what can be done while calling on a new generation of leaders to take the country back from the brink of destruction. The shocking revelations disclosed by El-Rufai about the formation of the current leadership and the actions of prominent statesmen make this memoir required reading for anyone seeking to understand the dynamics of power politics in Africa's most populous nation.
All over Africa, an explosion in cultural productions of various genres is in evidence. Whether in relation to music, song and dance, drama, poetry, film, documentaries, photography, cartoons, fine arts, novels and short stories, essays, and (auto)biography; the continent is experiencing a robust outpouring of creative power that is as remarkable for its originality as its all-round diversity. Beginning from the late 1970s and early 1980s, the African continent has experienced the longest and deepest economic crises than at any other time since the period after the Second World War. Interestingly however, while practically every indicator of economic development was declining in nominal and/ or real terms for most aspects of the continent, cultural productions were on the increase. Out of adversity, the creative genius of the African produced cultural forms that at once spoke to crises and sought to transcend them. The current climate of cultural pluralism that has been produced in no small part by globalization has not been accompanied by an adequate pluralism of ideas on what culture is, and/or should be; nor informed by an equal claim to the production of the cultural - packaged or not. Globalization has seen to movement and mixture, contact and linkage, interaction and exchange where cultural flows of capital, people, commodities, images and ideologies have meant that the globe has become a space, with new asymmetries, for an increasing intertwinement of the lives of people and, consequently, of a greater blurring of normative definitions as well as a place for re-definition, imagined and real. As this book - Contemporary African Cultural Productions - has done, researching into African culture and cultural productions that derive from it allows us, among other things, to enquire into definitions, explore historical dimensions, and interrogate the political dimensions to presentation and representation. The book therefore offers us an intervention that goes beyond the normative literary and cultural studies' main foci of race, difference and identity; notions which, while important in themselves might, without the necessary historicizing and interrogating, result in a discourse that rather re-inscribes the very patterns that necessitate writing against. This book is an invaluable compendium to scholars, researchers, teachers, students and others who specialize on different aspects of African culture and cultural productions, as well as cultural centers and general readers.
There is a general agreement that piracy; counterfeiting and passing off are unfair. However, there is often surreptitious - or even open - sympathy for, say, those who purchase counterfeit designer fashions or the latest technical gadgets. The pirate is even sometimes represented as a daring evil hero. In this book, Prof. Dora Nkem Akunyili, Director General of Nigeria's National Agency for Food and Drug Administration and Control, presents a unique study of a global phenomenon in which law-breaking and profiteering prevail at the cost of human health and life - and of the ways in which this can be fought by appropriate legislation, regulation and enforcement.
The Botsotso literary journal started in 1996 as a monthly 4 page insert in the New Nation, an independent anti-apartheid South African weekly and reached over 80,000 people at a time largely politisized black workers and youth with a selection of poems, short stories and short essays that reflected the deep changes taking place in the country at that time. Since the closure of the New Nation in 1999, the journal has evolved into a stand-alone compilation featuring the same mix of genres, and with the addition of photo essays and reviews. The Botsotso editorial policy remains committed to creating a mix of voices which highlight the diverse spectrum of South African identities and languages, particularly those that are dedicated to radical expression and examinations of South Africa's complex society.
The Botsotso literary journal started in 1996 as a monthly 4 page insert in the New Nation, an independent anti-apartheid South African weekly and reached over 80,000 people at a time ? largely politisized black workers and youth ? with a selection of poems, short stories and short essays that reflected the deep changes taking place in the country at that time. Since the closure of the New Nation in 1999, the journal has evolved into a stand-alone compilation featuring the same mix of genres, and with the addition of photo essays and reviews. The Botsotso editorial policy remains committed to creating a mix of voices which highlight the diverse spectrum of South African identities and languages, particularly those that are dedicated to radical expression and examinations of South Africa's complex society.
Most Nigerians, when they talk about Nigeria, will always refer to her with bubbling jingoism as 'giant of Africa' or 'our great nation, Nigeria' but fail to ask 'giant of what?' Goodness or Evil? Productivity or Consumption? Success or Failure? Meritocracy or Mediocrity? Hollowness or Substance? Capturing the 'mood of the nation' this book offers diagnosis on the country which are broad-based, instructive and well presented. Part I outlines the developmental stages of Nigeria while Part II gives an in depth diagnosis of the major problems besetting Nigeria, following Part III gives examples of nations and leadership traits Nigeria could emulate.
An important feature of Ghanaian tertiary education is the foundational African Studies Programme which was initiated in the early 1960s. Unfortunately hardly any readers exist which bring together a body of knowledge on the themes, issues and debates which inform and animate research and teaching in African Studies particularly on the African continent. This becomes even more important when we consider the need for knowledge on Africa that is not Eurocentric or sensationalised, but driven from internal understandings of life and prospects in Africa. Dominant representations and perceptions of Africa usually depict a continent in crisis. Rather than buying into external representations of Africa, with its 'lacks' and aspirations for Western modernities, we insist that African scholars in particular should be in the forefront of promoting understanding of the pluri-lingual, overlapping, and dense reality of life and developments on the continent, to produce relevant and usable knowledge. Continuing and renewed interest in Africa's resources, including the land mass, economy, minerals, visual arts and performance cultures, as well as bio-medical knowledge and products, by old and new geopolitical players, obliges African scholars to transcend disciplinary boundaries and to work with each other to advance knowledge and uses of those resources in the interests of Africa's people.
Theatre and drama are very much part of our every day lives. These four plays: Belonging by Mirirai Moyo, When I Meet my Mother by Kathleen McCreery, In the Continuum by Danai Gurira and Nikkole Salter, and Power Failure by Jide Afoylan reveal the dynamism and variety of theatre. They also reveal that from Zimbabwe to Brazil, Nigeria to the USA, societies despite their diversity share many common problems and challenges. Annotated for schools with questions and notes by Rory Kilalea, teachers and students will find this a richly accessible text.
The poems, stories and essays of Mphutlane wa Bofelo operate within a framework of thinking that is an amalgam of philosophies: that of black consciousness, humanistic Islam and socialism. His voice is both lyrical and satirical, expressing anger and tenderness even as his barbs are sharp and his kisses tender. His beats are complex polyrhythms that roll on in incantatory style or achieve mystical brevity. Bofelo entered the world of sociopolitical and cultural activism in the early 1980s through the black consciousness movement in Zamdela Township in Sasolburg. He lives in Durban, where he has built up an audience as a performer of poetry, a speaker and a facilitator. He has self-published two poetry collections and is represented in journals, newspapers and on web sites.
Understanding Confusion in Africa : The Politics of Multiculturalism and Nation-building in Cameroon
(2013)
Cameroon is often considered to be Africais legendary pathfinder. This book argues essentially that Cameroon cannot competently champion African unity and progress until it can correctly pursue its own multicultural nation-building. Cameroon's success continental-wise would depend on its theory and practice of multiculturalism, as particularly reflected in (1) the rejoicing in its historical diversity and the harmonious co-existence of its Systems of Education which must, of necessity, be linked to (2) effective federalization or decentralization of uniquely cultural matters. Critically examining history and education as components of culture, and therefore, of multiculturalism, the book makes some bold recommendations while demonstrating how nation-building is meaningless without the peopleis authentic history. It argues that Cameroon national culture cannot be a national culture without embodying the distinct culture of the English-speaking minority. Anything else is nothing but deliberate confusion of assimilation for multiculturalism, a confusion that is heavily tied to the countryis phoney independence. Hinging on education (and its associates of bilingualism and bijuralism), the book demonstrates that Cameroonis over-sung cultural dualism is a charade, epitomized by the 1998 Education Law. Rather than reaffirm Cameroonis biculturalism as it superficially avows, Cameroonis purported cultural dualism is really out to efface any semblance of cultural or educational dualism that may still be resisting assimilation. The continuous and persistent employment of terms such as biculturalism, bilingualism and bijuralism in legal texts in Cameroon is only to confuse the international community, especially from seeing exactly the kind of eethnic cleansingi which is taking place in the country.