Refine
Year of publication
Document Type
- Article (380)
- Preprint (246)
- Working Paper (4)
- Part of Periodical (2)
- Conference Proceeding (1)
- Contribution to a Periodical (1)
Has Fulltext
- yes (634)
Is part of the Bibliography
- no (634)
Keywords
- BESIII (19)
- e +-e − Experiments (16)
- Branching fraction (12)
- Particle and Resonance Production (8)
- Quarkonium (7)
- Charm Physics (6)
- Spectroscopy (6)
- Hadronic decays (5)
- Branching fractions (4)
- Charmonium (4)
- Exotics (4)
- Heavy-ion collisions (4)
- Lepton colliders (4)
- SARS-CoV-2 (4)
- COVID19-NMR (3)
- Charmed mesons (3)
- Deutschland (3)
- Diffraction (3)
- Elastic scattering (3)
- Electroweak interaction (3)
- Genetics (3)
- Initial state radiation (3)
- Polarization (3)
- QCD (3)
- e+-e− Experiments (3)
- Absolute branching fraction (2)
- Beam Energy Scan (2)
- Bhabha (2)
- COVID-19 (2)
- Charm physics (2)
- Chiral Magnetic Effect (2)
- Collectivity (2)
- Correlation (2)
- Cross section (2)
- Electroweak Interaction (2)
- Everolimus (2)
- Flavour Physics (2)
- Hadronic cross section (2)
- Kidney transplantation (2)
- Leptonic, semileptonic & radiative decays (2)
- Marktanteil (2)
- Molecular biology (2)
- Muon anomaly (2)
- NMR (2)
- Particle decays (2)
- Pion form factor (2)
- RHIC (2)
- Radiative decay (2)
- STAR (2)
- Shear viscosity (2)
- Solution NMR spectroscopy (2)
- decays (2)
- pest risk mapping (2)
- risk factors (2)
- 5'-UTR (1)
- 5_SL4 (1)
- 5′-UTR (1)
- 889 vs R. pygmaea (Brauer, 1867) (1)
- ACLF (1)
- ALK-rearranged NSCLC (1)
- ARDS (1)
- Absatzweg (1)
- Abwanderung-Widerspruch-Theorie (1)
- Advanced biliary tract cancer (1)
- Age estimation (1)
- American crocodile (1)
- Angular distribution (1)
- Annihilation (1)
- Antibody-mediated rejection (1)
- Archibasis (1)
- Atmospheric chemistry (1)
- B-slope (1)
- BESIII detector (1)
- BTC (1)
- Bacterial Protein Kinases (1)
- Bacterial Protein Phosphatases (1)
- Barcoding (1)
- Beam energy scan (1)
- Biogeography (1)
- Biological profile (1)
- Biopsy (1)
- Bipolar disorder (1)
- Born cross section (1)
- Born cross section measurement (1)
- Brain tumor (1)
- Branching fraction measurement (1)
- Burden of disease (1)
- CAKUT (1)
- CP violation (1)
- CRM (1)
- CVD biomarker (1)
- Cardiac implantable electronic devices (1)
- Cardiac rehabilitation (1)
- Cardiac resynchronization therapy (1)
- Cardiovascular disease (1)
- Carnivores (1)
- Cdk1/cyclin B1 (1)
- Charged-particle multiplicity (1)
- Charm quark spatial diffusion coefficient (1)
- Charm vector (1)
- Charmed baryon (1)
- Charmonia (1)
- Charmonium (-like) (1)
- Child abuse (1)
- Chiral magnetic effect (1)
- Circadian (1)
- Cirrhosis (1)
- Climate-change impacts (1)
- Coalescence (1)
- Cold nuclear matter effects (1)
- Colorectal cancer (1)
- Consensus document (1)
- Costa Rica (1)
- Covariance matrix (1)
- Credit union (1)
- Critical care (1)
- Critical point (1)
- Crocodylus acutus (1)
- Cross section measurements (1)
- Cryptic species (1)
- D meson (1)
- D0 and D+ mesons (1)
- DIPSHIFT (1)
- DNA barcodingbased identification (1)
- Dalitz decay (1)
- Dark photon (1)
- Dark sector (1)
- Data sharing (1)
- Density equalizing mapping (1)
- Deuteron production (1)
- Devic disease (1)
- Devic syndrome (1)
- Di-hadron correlations (1)
- Diabetes (1)
- Diabetes mellitus (1)
- Digital (1)
- Divergence time estimate (1)
- Drug Resistance (1)
- D⁰ meson (1)
- EWSR1 (1)
- Ecology (1)
- Ecophysiology (1)
- Effective form factor (1)
- Electromagnetic amplitude (1)
- Electromagnetic form factor (1)
- Electromagnetic form factors (1)
- Elliptic flow (1)
- Entomology (1)
- Equity (1)
- Exercise training (1)
- Experimental nuclear physics (1)
- Experimental particle physics (1)
- FOS: Physical sciences (1)
- Flavor changing neutral currents (1)
- Flavor symmetries (1)
- Flow (1)
- Fonds (1)
- Forensic examination (1)
- Forensic pathology (1)
- Form factors (1)
- Forward physics (1)
- G protein-coupled receptors (1)
- Gene fusion (1)
- Generalist (1)
- German Corporate Governance System (1)
- Geschichte 1986-1998 (1)
- Glomerulosclerosis (1)
- Groomed jet radius (1)
- HCC (1)
- Hadron-Hadron scattering (experiments) (1)
- Hadronization (1)
- Hadrons (1)
- Hand-foot syndrome (1)
- Health care resource utilization (1)
- Heart failure (1)
- Heavy Ion Experiments (1)
- Heavy Quark Production (1)
- Heavy ion collisions (1)
- Heavy-Ion Collision (1)
- Heavy-flavor decay electron (1)
- Heavy-ion (1)
- Helicity amplitude analysis (1)
- Hif1α (1)
- High Energy Physics - Experiment (hep-ex) (1)
- Higher moments (1)
- Human-mediated dispersal (1)
- Hyperons (1)
- Immunogenetics (1)
- Immunology (1)
- Implantable cardioverter-defibrillator (1)
- Inclusive branching fraction (1)
- Interference fragmentation function (1)
- Intimal-medial thickness (1)
- Investmentfonds (1)
- Invisible decays (1)
- J/ψ suppression (1)
- Jet substructure (1)
- K0S (1)
- K48-linked (1)
- K63-linked (1)
- Kreditgenossenschaft (1)
- Kreditgenossenschaftlicher Verbund (1)
- Lifestyle (1)
- Limón (1)
- Low Molecular Weight PTP (1)
- MN1 (1)
- MS (1)
- Macrodomain (1)
- Macromia (1)
- Mergers and Acquisitions (1)
- Metabolic syndrome (1)
- Mitgliedschaft (1)
- Mongolian spot (1)
- MptpA (1)
- Multiple parton interactions (1)
- Mycobacterium tuberculosis (1)
- NAFLD (1)
- NASH (1)
- NMO-IgG (1)
- NMR spectroscopy (1)
- Net-charge correlations (1)
- Net-charge fluctuations (1)
- Neuroepithelial (1)
- Neuromyelitis optica (1)
- Neurooncology (1)
- Neutrinos (1)
- Nevus of Ito (1)
- Nevus of Ota (1)
- Non-structural protein (1)
- Nonflow (1)
- Obesity (1)
- Oncogenes (1)
- Outcome (1)
- PATZ1 (1)
- PDGFRβ (1)
- PTDM (1)
- Pacemaker (1)
- Particle and resonance production (1)
- Particle phenomena (1)
- Patient safety (1)
- Pediatric (1)
- Phase (1)
- Phyllothemis raymondi (1)
- Phylogenomics (1)
- Phylogeny (1)
- Phylogeography (1)
- Physical activity (1)
- Population genetics (1)
- Post-transplant (1)
- Poverty (1)
- Prevention (1)
- Prognostic models (1)
- Protein drugability (1)
- Proton (1)
- Proton-proton collisions (1)
- Proton–proton collisions (1)
- Psychiatric disorders (1)
- Psychiatry (1)
- PtkA (1)
- Quantum chromodynamics (1)
- R value (1)
- RNA genome (1)
- Raiffeisenbank (1)
- Randomized (1)
- Rare decays (1)
- Research architecture (1)
- Risk aversion (1)
- SL1 (1)
- SLC20A1 (1)
- SPSS (1)
- Schätzung (1)
- Sclerotic glomeruli (1)
- Seasonal variation (1)
- Semi-leptonic decays (1)
- Social determinants (1)
- SoftDrop (1)
- Solar insolation (1)
- Solution NMR-spectroscopy (1)
- Sorafenib (1)
- Spin alignment (1)
- Spine care (1)
- Splitting function (1)
- Standardization (1)
- Strong amplitude (1)
- Suicide (1)
- Sunlight (1)
- TOR inhibitor (1)
- TP53 mutation status (1)
- Techniques Electromagnetic calorimeters (1)
- Thermal model (1)
- Threshold effect (1)
- Transversity (1)
- Triple quarkonia (1)
- USA (1)
- V. sotoarenasii (1)
- VEGFR-2 (1)
- VEGFR-3 (1)
- Vanilla planifolia (1)
- Vitamin D (1)
- Volksbank (1)
- Vulpes (1)
- W-exchange (1)
- Wachstum (1)
- Y (4260) (1)
- Y states (1)
- abnormal returns (1)
- accessory proteins (1)
- acute decompensation (1)
- acute-on-chronic liver failure (1)
- adaptive cardiac remodelling (1)
- adverse effects (1)
- aged (1)
- aging (1)
- alternative oxidase (1)
- aquaporin-4 (AQP4) antibody (1)
- bladder exstrophy-epispadias complex (1)
- branching fractions (1)
- c-kit (1)
- cancer (1)
- cardiac ischaemia‐reperfusion (1)
- cardiac magnetic (1)
- cardiomyopathy (1)
- cell stress (1)
- cell-free expression (1)
- cell-free protein synthesis (1)
- center-of-mass energy (1)
- cerebrospinal fluid (1)
- charmed baryon (1)
- charmonium-like states (1)
- chromosome segregation (1)
- cirrhosis (1)
- clinical features (1)
- cloacal malformation (1)
- common bond (1)
- complications (1)
- computed tomography (1)
- consensus (1)
- decay (1)
- decision-making under uncertainty (1)
- dimuon (1)
- diphoton (1)
- distribution channel (1)
- dynamics (1)
- e+e − annihilation (1)
- e+e⁻ − Experiments (1)
- e+e− Experiments (1)
- e+e− annihilation (1)
- ectosomes (1)
- electron transport chain (1)
- electron-positron collision (1)
- epidemiology (1)
- exosomes (1)
- extracellular vesicles (1)
- firewood (1)
- firewood movement (1)
- forest pests (1)
- functional genetics (1)
- fund growth (1)
- global change (1)
- guidelines (1)
- habitat destruction (1)
- hadron spectroscopy (1)
- hadronic events (1)
- heavy-ion collisions (1)
- helicity amplitude analysis (1)
- hepatic encephalopathy (1)
- inclusive J/ψ decays (1)
- inflammation (1)
- intrinsically disordered region (1)
- investment decisions (1)
- kidney formation (1)
- land use (1)
- left ventricular non-compaction (1)
- left ventricular trabeculation (1)
- liver (1)
- longitudinally extensive transverse myelitis (1)
- luminosity (1)
- mTOR inhibitor (1)
- magic angle spinning (1)
- magnetic resonance imaging (1)
- market shares (1)
- metabolic syndromes (1)
- microparticles (1)
- microvesicles (1)
- minimal information requirements (1)
- mitosis (1)
- mortality (1)
- mouse (1)
- mtDNA (1)
- mtDNA control region (1)
- mutual fund performance (1)
- mutual funds (1)
- network modelling (1)
- neurodegeneration (1)
- nonstructural proteins (1)
- number of J/ψ events (1)
- osteoporosis (1)
- p+p collisions (1)
- p21 phosphorylation (1)
- p21 stability (1)
- participation rate (1)
- pathway invasion model (1)
- pedicle screws (1)
- peri-implantitis (1)
- polyubiquitin (1)
- portal hypertension (1)
- portosystemic shunt (1)
- radiation (1)
- reactive oxygen species (1)
- recurrent optic neuritis (1)
- reproducibility (1)
- resonance (1)
- rigor (1)
- risk factor progression (1)
- screw augmentation (1)
- screw loosening (1)
- semi-parametric estimation (1)
- sequential ALK-inhibitor therapy (1)
- simulation (1)
- spinal fusion (1)
- spontaneous portosystemic shunt (1)
- standardization (1)
- stochastic dominance (1)
- stroke (1)
- structural proteins (1)
- taxonomic status of Rhyothemis fulgens Kirby (1)
- tetraquark (1)
- thrombolysis (1)
- training (1)
- trigger efficiency (1)
- ubiquitin-conjugating enzymes (1)
- uncertainty (1)
- urinary tract development (1)
- zebrafish development (1)
- Λ+c baryon (1)
- Λc⁺ (1)
- Σ hyperon (1)
- Υ suppression (1)
- ψ(3686) (1)
Institute
The SARS-CoV-2 virus is the cause of the respiratory disease COVID-19. As of today, therapeutic interventions in severe COVID-19 cases are still not available as no effective therapeutics have been developed so far. Despite the ongoing development of a number of effective vaccines, therapeutics to fight the disease once it has been contracted will still be required. Promising targets for the development of antiviral agents against SARS-CoV-2 can be found in the viral RNA genome. The 5′- and 3′-genomic ends of the 30 kb SCoV-2 genome are highly conserved among Betacoronaviruses and contain structured RNA elements involved in the translation and replication of the viral genome. The 40 nucleotides (nt) long highly conserved stem-loop 4 (5_SL4) is located within the 5′-untranslated region (5′-UTR) important for viral replication. 5_SL4 features an extended stem structure disrupted by several pyrimidine mismatches and is capped by a pentaloop. Here, we report extensive 1H, 13C, 15N and 31P resonance assignments of 5_SL4 as the basis for in-depth structural and ligand screening studies by solution NMR spectroscopy.
Background and Objectives: Proteins of the coagulation system contribute to autoimmune inflammation in patients with multiple sclerosis (MS). On blood-brain barrier (BBB) disruption, fibrinogen enters the CNS and is rapidly converted to fibrin, unfolding pleiotropic autoimmune mechanisms. Fibrin accumulation leads to subsequent proteolytic degradation that results in D-dimer generation. The primary objective of this study was to determine intrathecal levels of D-dimer in CSF as a measure of intrathecal coagulation cascade activation and to evaluate its diagnostic utility in patients with MS in contrast to healthy subjects. Key secondary objectives included analysis of CSF D-dimer in differential diagnoses of MS and its relation to routine clinical markers of disease activity.
Methods: Patients admitted for the assessment of suspected MS were prospectively recruited from October 2017 to December 2020. Blood plasma and citrated CSF samples were analyzed using a highly sensitive luminescent oxygen channeling immunoassay. Intrathecal generation of D-dimer was analyzed by adjusting for CSF/serum albumin (Qalb) and CSF/plasma D-dimer quotients (QD-dimer), and corresponding CSF fibrinogen levels were determined. Final diagnoses after full evaluation and clinical data were recorded.
Results: Of 187 patients, 113 patients received a diagnosis of MS or clinically/radiologically isolated syndrome. We found increased intrathecal CSF D-dimer generation levels (QD-dimer/Qalb-index) for patients with relapsing-remitting MS (RRMS; n = 71, median 4.7, interquartile range [IQR] 2.5–8.0) when compared with those for disease controls (n = 22, median 2.6, IQR 2.1–4.8, p = 0.031). Absolute CSF D-dimer values correlated with CSF fibrinogen levels (r = 0.463; p < 0 .001) and CSF leukocytes (r = 0.273; p = 0.003) and were elevated in MS patients with contrast enhancement (CE) compared with MS patients without CE on MRI (n = 48, median 6 ng/mL, and IQR 3–15.25 vs n = 41, median 4 ng/mL, and IQR 2–7; p = 0.026). Exploratory subgroup analyses indicated a correlation of intrathecal inflammatory activity and CSF D-dimer levels.
Discussion: D-dimer in CSF can be reliably determined and correlates with markers of CNS inflammation and CSF fibrinogen levels. Adjusted for BBB dysfunction, CSF D-dimer may allow the identification of intrathecal coagulation cascade activation in patients with MS.
Classification of Evidence: This study provides Class I evidence that CSF D-dimer levels are elevated in patients with RRMS.
We study a set of German open-end mutual funds for a time period during which this industry emerged from its infancy. In those years, the distribution channel for mutual funds was dominated by the brick-and-mortar retail networks of the large universal banks. Using monthly observations from 12/1986 through 12/1998, we investigate if cross-sectional return differences across mutual funds affect their market shares. Although such a causal relation has been established in highly competitive markets, such as the United States, the rigid distribution system in place in Germany at the time may have caused retail performance and investment performance to uncouple. In fact, although we observe stark differences in investment performance across mutual funds (and over time), we find no evidence that cross-sectional performance differences affect the market shares of these funds. Klassifikation: G 23
Background Anti-angiogenic treatment is believed to have at least cystostatic effects in highly vascularized tumours like pancreatic cancer. In this study, the treatment effects of the angiogenesis inhibitor Cilengitide and gemcitabine were compared with gemcitabine alone in patients with advanced unresectable pancreatic cancer. Methods A multi-national, open-label, controlled, randomized, parallel-group, phase II pilot study was conducted in 20 centers in 7 countries. Cilengitide was administered at 600 mg/m2 twice weekly for 4 weeks per cycle and gemcitabine at 1000 mg/m2 for 3 weeks followed by a week of rest per cycle. The planned treatment period was 6 four-week cycles. The primary endpoint of the study was overall survival and the secondary endpoints were progression-free survival (PFS), response rate, quality of life (QoL), effects on biological markers of disease (CA 19.9) and angiogenesis (vascular endothelial growth factor and basic fibroblast growth factor), and safety. An ancillary study investigated the pharmacokinetics of both drugs in a subset of patients. Results Eighty-nine patients were randomized. The median overall survival was 6.7 months for Cilengitide and gemcitabine and 7.7 months for gemcitabine alone. The median PFS times were 3.6 months and 3.8 months, respectively. The overall response rates were 17% and 14%, and the tumor growth control rates were 54% and 56%, respectively. Changes in the levels of CA 19.9 went in line with the clinical course of the disease, but no apparent relationships were seen with the biological markers of angiogenesis. QoL and safety evaluations were comparable between treatment groups. Pharmacokinetic studies showed no influence of gemcitabine on the pharmacokinetic parameters of Cilengitide and vice versa. Conclusion There were no clinically important differences observed regarding efficacy, safety and QoL between the groups. The observations lay in the range of other clinical studies in this setting. The combination regimen was well tolerated with no adverse effects on the safety, tolerability and pharmacokinetics of either agent.
Background: The objective of the STREAM Trial was to evaluate the effect of simulation training on process times in acute stroke care.
Methods: The multicenter prospective interventional STREAM Trial was conducted between 10/2017 and 04/2019 at seven tertiary care neurocenters in Germany with a pre- and post-interventional observation phase. We recorded patient characteristics, acute stroke care process times, stroke team composition and simulation experience for consecutive direct-to-center patients receiving intravenous thrombolysis (IVT) and/or endovascular therapy (EVT). The intervention consisted of a composite intervention centered around stroke-specific in situ simulation training. Primary outcome measure was the ‘door-to-needle’ time (DTN) for IVT. Secondary outcome measures included process times of EVT and measures taken to streamline the pre-existing treatment algorithm.
Results: The effect of the STREAM intervention on the process times of all acute stroke operations was neutral. However, secondary analyses showed a DTN reduction of 5 min from 38 min pre-intervention (interquartile range [IQR] 25–43 min) to 33 min (IQR 23–39 min, p = 0.03) post-intervention achieved by simulation-experienced stroke teams. Concerning EVT, we found significantly shorter door-to-groin times in patients who were treated by teams with simulation experience as compared to simulation-naive teams in the post-interventional phase (−21 min, simulation-naive: 95 min, IQR 69–111 vs. simulation-experienced: 74 min, IQR 51–92, p = 0.04).
Conclusion: An intervention combining workflow refinement and simulation-based stroke team training has the potential to improve process times in acute stroke care.
Peri-implantitis: summary and consensus statements of group 3. The 6th EAO Consensus Conference 2021
(2021)
Objective: To evaluate the influence of implant and prosthetic components on peri-implant tissue health. A further aim was to evaluate peri-implant soft-tissue changes following surgical peri-implantitis treatment. Materials and methods: Group discussions based on two systematic reviews (SR) and one critical review (CR) addressed (i) the influence of implant material and surface characteristics on the incidence and progression of peri-implantitis, (ii) implant and restorative design elements and the associated risk for peri-implant diseases, and (iii) peri-implant soft-tissue level changes and patient-reported outcomes following peri-implantitis treatment. Consensus statements, clinical recommendations, and implications for future research were discussed within the group and approved during plenary sessions. Results: Data from preclinical in vivo studies demonstrated significantly greater radiographic bone loss and increased area of inflammatory infiltrate at modified compared to non-modified surface implants. Limited clinical data did not show differences between modified and non-modified implant surfaces in incidence or progression of peri-implantitis (SR). There is some evidence that restricted accessibility for oral hygiene and an emergence angle of >30 combined with a convex emergence profile of the abutment/prosthesis are associated with an increased risk for peri-implantitis (CR). Reconstructive therapy for peri-implantitis resulted in significantly less soft-tissue recession, when compared with access flap. Implantoplasty or the adjunctive use of a barrier membrane had no influence on the extent of peri-implant mucosal recession following peri-implantitis treatment (SR).
The neutron capture cross section of 58Ni was measured at the neutron time of flight facility n_TOF at CERN, from 27 meV to 400 keV neutron energy. Special care has been taken to identify all the possible sources of background, with the so-called neutron background obtained for the first time using high-precision GEANT4 simulations. The energy range up to 122 keV was treated as the resolved resonance region, where 51 resonances were identified and analyzed by a multilevel R-matrix code SAMMY. Above 122 keV the code SESH was used in analyzing the unresolved resonance region of the capture yield. Maxwellian averaged cross sections were calculated in the temperature range of kT = 5 – 100 keV, and their astrophysical implications were investigated.
Background: School attendance during the SARS-CoV-2 pandemic is intensely debated. Modelling studies suggest that school closures contribute to community transmission reduction. However, data among school-attending students and staff are scarce. In November 2020, we examined SARS-CoV-2 infections and seroreactivity in 24 randomly selected school classes and connected households in Berlin, Germany.
Methods: Students and school staff were examined, oro-nasopharyngeal swabs and blood samples collected, and SARS-CoV-2 infection and IgG antibodies detected by RT-PCR and ELISA. Household members performed self-swabs. Individual and institutional infection prevention and control measures were assessed. Classes with SARS-CoV-2 infection and connected household members were re-tested after one week.
Findings: 1119 participants were examined, including 177 primary and 175 secondary school students, 142 staff, and 625 household members. Participants reported mainly cold symptoms (19·4%). SARS-CoV-2 infection occurred in eight of 24 classes affecting each 1-2 individuals. Infection prevalence was 2·7% (95%CI; 1·2-5·0%; 9/338), 1·4% (0·2-5·1%; 2/140), and 2·3% (1·3-3·8%; 14/611) among students, staff and household members, respectively, including quarantined persons. Six of nine infected students were asymptomatic. Prevalence increased with inconsistent facemask use in school, way to school on foot, and case-contacts outside school. IgG antibodies were detected in 2·0% (0·8-4·1%; 7/347), 1·4% (0·2-5·0%; 2/141) and 1·4% (0·6-2·7%; 8/576), respectively. For three of nine households with infection(s) detected at cross-sectional assessment, origin in school seemed possible. After one week, no school-related, secondary infections appeared in affected classes; the attack rate in connected households was 1·1%.
Interpretation: These data suggest that school attendance under preventive measures is feasible, provided their rigorous implementation. In balancing threats and benefits of open versus closed schools during the pandemic, parents and society need to consider possible spill-overs into their households. Deeper insight is needed into the infection risks due to being a schoolchild as compared to attending school.
Background: School attendance during the COVID-19 pandemic is intensely debated.
Aim: In November 2020, we assessed SARS-CoV-2 infections and seroreactivity in 24 randomly selected school classes and connected households in Berlin, Germany.
Methods: We collected oro-nasopharyngeal swabs and blood samples, examining SARS-CoV-2 infection and IgG antibodies by RT-PCR and ELISA. Household members self-swabbed. We assessed individual and institutional prevention measures. Classes with SARS-CoV-2 infection and connected households were retested after 1 week.
Results: We examined 1,119 participants, including 177 primary and 175 secondary school students, 142 staff and 625 household members. SARS-CoV-2 infection occurred in eight classes, affecting each 1–2 individuals. Infection prevalence was 2.7% (95% confidence interval (CI): 1.2–5.0; 9/338), 1.4% (95% CI: 0.2–5.1; 2/140), and 2.3% (95% CI: 1.3–3.8; 14/611) among students, staff and household members. Six of nine infected students were asymptomatic at testing. We detected IgG antibodies in 2.0% (95%CI: 0.8–4.1; 7/347), 1.4% (95% CI: 0.2–5.0; 2/141) and 1.4% (95% CI: 0.6–2.7; 8/576). Prevalence increased with inconsistent facemask-use in school, walking to school, and case-contacts outside school. For three of nine households with infection(s), origin in school seemed possible. After 1 week, no school-related secondary infections appeared in affected classes; the attack rate in connected households was 1.1%.
Conclusion: School attendance under rigorously implemented preventive measures seems reasonable. Balancing risks and benefits of school closures need to consider possible spill-over infection into households. Deeper insight is required into the infection risks due to being a schoolchild vs attending school.
An important experimental program on Nuclear Astrophysics is being carried out at the n_TOF since several years, in order to address the still open issues in stellar and primordial nucleosynthesis. Several neutron capture reactions relevant to s-process nucleosynthesis have been measured so far, some of which on important branching point radioisotopes. Furthermore, the construction of a second experimental area has recently opened the way to challenging measurements of (n, charged particle) reactions on isotopes of short half-life. The Nuclear Astrophysics program of the n_TOF Collaboration is here described, with emphasis on recent results relevant for stellar nucleosynthesis, stellar neutron sources and primordial nucleosynthesis.