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Peri-implantitis: summary and consensus statements of group 3. The 6th EAO Consensus Conference 2021
(2021)
Schwarz, Frank ; Alcoforado, Gil ; Guerrero, Adrian ; Jönsson, Daniel ; Klinge, Björn ; Lang, Niklaus P. ; Mattheos, Nikos ; Mertens, Brenda Nilufar ; Pitta, João ; Ramanauskaite, Ausra ; Sayardoust, Shariel ; Sanz-Martin, Ignacio ; Stavropoulos, Andreas ; Heitz-Mayfield, Lisa J. A.
Objective: To evaluate the influence of implant and prosthetic components on peri-implant tissue health. A further aim was to evaluate peri-implant soft-tissue changes following surgical peri-implantitis treatment. Materials and methods: Group discussions based on two systematic reviews (SR) and one critical review (CR) addressed (i) the influence of implant material and surface characteristics on the incidence and progression of peri-implantitis, (ii) implant and restorative design elements and the associated risk for peri-implant diseases, and (iii) peri-implant soft-tissue level changes and patient-reported outcomes following peri-implantitis treatment. Consensus statements, clinical recommendations, and implications for future research were discussed within the group and approved during plenary sessions. Results: Data from preclinical in vivo studies demonstrated significantly greater radiographic bone loss and increased area of inflammatory infiltrate at modified compared to non-modified surface implants. Limited clinical data did not show differences between modified and non-modified implant surfaces in incidence or progression of peri-implantitis (SR). There is some evidence that restricted accessibility for oral hygiene and an emergence angle of >30 combined with a convex emergence profile of the abutment/prosthesis are associated with an increased risk for peri-implantitis (CR). Reconstructive therapy for peri-implantitis resulted in significantly less soft-tissue recession, when compared with access flap. Implantoplasty or the adjunctive use of a barrier membrane had no influence on the extent of peri-implant mucosal recession following peri-implantitis treatment (SR).
Inostroza, Pedro A. ; Elgueta, Sebastian ; Muz, Melis ; Krauss, Martin ; Brack, Werner ; Backhaus, Thomas
Chemical pollution caused by synthetic organic chemicals at low concentrations in the environment poses a growing threat to the ecological status of aquatic ecosystems. These chemicals are regularly released into surface waters through both treated and untreated effluents from wastewater treatment plants (WWTPs), agricultural runoff, and industrial discharges. Consequently, they accumulate in surface waters, distribute amongst environmental compartments according to their physicochemical properties, and cause adverse effects on aquatic organisms. Unfortunately, there is a lack of data regarding the occurrence of synthetic organic chemicals, henceforth micropollutants, in South American freshwater ecosystems, especially in Chile.
To address this research gap, we present a comprehensive dataset comprising concentrations of 153 emerging chemicals, including pesticides, pharmaceutical and personal care products (PPCPs), surfactants, and industrial chemicals. These chemicals were found to co-occur in surface waters within Central Chile, specifically in the River Aconcagua Basin. Our sampling strategy involved collecting surface water samples from streams and rivers with diverse land uses, such as agriculture, urban areas, and natural reserves. For sample extraction, we employed an on-site large-volume solid phase extraction (LVSPE) device. The resulting environmental extracts were then subjected to wide-scope chemical target screening using gas chromatography and liquid chromatography high-resolution mass spectrometry (GC- and LCsingle bondHRMS).
The dataset we present holds significant value in assessing the chemical status of water bodies. It enables comparative analysis of pollution fingerprints associated with emerging chemicals across different freshwater systems. Moreover, the data can be reused for environmental risk assessment studies. Its utilisation will contribute to a better understanding of the impact and extent of chemical pollution in aquatic ecosystems, facilitating the development of effective mitigation strategies.
Weiß, Roxanne ; Guchlerner, Leon ; Loth, Andreas German ; Leinung, Martin ; Wicker, Sabine ; Kempf, Volkhard A. J. ; Berger, Annemarie ; Rabenau, Holger ; Ciesek, Sandra ; Stöver, Timo ; Diensthuber, Marc
Purpose: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) replicates predominantly in the upper respiratory tract and is primarily transmitted by droplets and aerosols. Taking the medical history for typical COVID-19 symptoms and PCR-based SARS-CoV-2 testing have become established as screening procedures. The aim of this work was to describe the clinical appearance of SARS-CoV-2-PCR positive patients and to determine the SARS-CoV-2 contact risk for health care workers (HCW).
Methods: The retrospective study included n = 2283 SARS-CoV-2 PCR tests from n = 1725 patients with otorhinolaryngological (ORL) diseases performed from March to November 2020 prior to inpatient treatment. In addition, demographic data and medical history were assessed.
Results: n = 13 PCR tests (0.6%) were positive for SARS-CoV-2 RNA. The positive rate showed a significant increase during the observation period (p < 0.01). None of the patients had clinical symptoms that led to a suspected diagnosis of COVID-19 before PCR testing. The patients were either asymptomatic (n = 4) or had symptoms that were interpreted as symptoms typical of the ORL disease or secondary diagnoses (n = 9).
Conclusion: The identification of SARS-CoV-2-positive patients is a considerable challenge in clinical practice. Our findings illustrate that taking a medical history alone is of limited value and cannot replace molecular SARS-CoV-2 testing, especially for patients with ORL diseases. Our data also demonstrate that there is a high probability of contact with SARS-CoV-2-positive patients in everyday clinical practice, so that the use of personal protective equipment, even in apparently “routine cases”, is highly recommended.
Schaller-Paule, Martin A. ; Förch, Christian ; Bohmann, Ferdinand ; Lapa, Sriramya ; Misselwitz, Björn ; Kohlhase, Konstantin David ; Rosenow, Felix ; Strzelczyk, Adam ; Willems, Laurent
Objective: To assess predictive factors for poststroke pneumonia (PSP) in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) of the anterior circulation, with special regard to the impact of intravenous thrombolysis (IVT) and endovascular treatment (EVT) on the risk of PSP. As a secondary goal, the validity of the A2DS2, PNEUMONIA, and ISAN scores in LVO will be determined.
Methods: Analysis was based on consecutive data for the years 2017 to 2019 from the prospective inpatient stroke registry covering the entire federal state of Hesse, Germany, using the Kruskal-Wallis test and binary logistic regression.
Results: Data from 4,281 patients with LVO were included in the analysis (54.8% female, median age = 78 years, range = 18–102), of whom 66.4% (n = 2,843) received recanalization therapy (RCT). In total, 19.4% (n = 832) of all LVO patients developed PSP. Development of PSP was associated with an increase in overall in-hospital mortality of 32.1% compared with LVO patients without PSP (16.4%; p < 0.001). Incidence of PSP was increased in 2132 patients with either EVT (n = 928; 25.9% PSP incidence) or combined EVT plus IVT (n = 1,204; 24.1%), compared with 2,149 patients with IVT alone (n = 711; 15.2%) or conservative treatment only (n = 1,438; 13.5%; p < 0.001). Multivariate analysis identified EVT (OR 1.5) and combined EVT plus IVT (OR 1.5) as significant independent risk factors for PSP. Furthermore, male sex (OR 1.9), age ≥ 65 years (OR 1.7), dysphagia (OR 3.2) as well as impaired consciousness at arrival (OR 1.7) and the comorbidities diabetes (OR 1.4) and atrial fibrillation (OR 1.3) were significantly associated risk factors (each p < 0.001). Minor stroke (NIHSS ≤ 4) was associated with a significant lower risk of PSP (OR 0.5). Performance of risk stratification scores varied between A2DS2 (96.1% sensitivity, 20.7% specificity), PNEUMONIA (78.2% sensitivity and 45.1% specificity) and ISAN score (98.0% sensitivity, 20.0% specificity).
Conclusion: Nearly one in five stroke patients with LVO develops PSP during acute care. This risk of PSP is further increased if an EVT is performed. Other predictive factors are consistent with those previously described for all AIS patients. Available risk stratification scores proved to be sensitive tools in LVO patients but lack specificity.
SARS-CoV-2 and stroke characteristics: a report from the Multinational COVID-19 Stroke Study Group
(2020)
Shahjouei, Shima ; Tsivgoulis, Georgios ; Farahmand, Ghasem ; Koza, Eric ; Mowla, Ashkan ; Vafaei Sadr, Alireza ; Kia, Arash ; Vaghefi Far, Alaleh ; Mondello, Stefania ; Cernigliaro, Achille ; Ranta, Annemarei ; Punter, Martin ; Khodadadi, Faezeh ; Sabra, Mirna ; Ramezani, Mahtab ; Naderi, Soheil ; Olulana, Oluwaseyi ; Chaudhary, Durgesh ; Lyoubi, Aicha ; Campbell, Bruce ; Arenillas, Juan F. ; Bock, Daniel ; Montaner, Joan ; Aghayari Sheikh Neshin, Saeideh ; Sousa, Diana Aguiar de ; Tenser, Matthew S. ; Aires, Ana ; De Lera Alfonso, Merccedes ; Alizada, Orkhan ; Azevedo, Elsa ; Goyal, Nitin ; Babaeepour, Zabihollah ; Banihashemi, Gelareh ; Bonati, Leo ; Cereda, Carlo ; Chang, Jason J. ; Crnjakovic, Miljenko ; De Marchis, Gian Marco ; Del Sette, Massimo ; Ebrahimzadeh, Seyed Amir ; Farhoudi, Mehdi ; Gandoglia, Ilaria ; Gonçalves, Bruno ; Griessenauer, Christoph J. ; Murat Hancı, Mehmet ; Katsanos, Aristeides H. ; Krogias, Christos ; Leker, Ronen ; Lotman, Lev ; Mai, Jeffrey ; Male, Shailesh ; Malhotra, Konark ; Malojcic, Branko ; Mesquita, Teresa ; Mir Ghasemi, Asadollah ; Aref, Hany Mohamed ; Mohseni Afshar, Zeinab ; Moon, Jusun ; Niemelä, Mika ; Rezaei Jahromi, Behnam ; Nolan, Lawrence ; Pandhi, Abhi ; Park, Jong-Ho ; Pedro Marto, João ; Purroy, Francisco ; Ranji-Burachaloo, Sakineh ; Carreira, Nuno Reis ; Requena, Manuel ; Rubiera del Fueyo, Marta A. ; Sajedi, Seyed Aidin ; Sargento-Freitas, João ; Sharma, Vijay ; Steiner, Thorsten ; Tempro, Kristi ; Turc, Guillaume ; Ahmadzadeh, Yassaman ; Almasi Dooghaee, Mostafa ; Assarzadegan, Farhad ; Babazadeh, Arefeh ; Baharvahdat, Humain ; Cardoso, Fabricio ; Dev, Apoorva ; Ghorbani, Mohammad ; Hamidi, Ava ; Sadat Hasheminejad, Zeynab ; Hojjat-Anasri Komachali, Sahar ; Khorvash, Fariborz ; Kobeissy, Firas ; Mirkarimi, Hamidreza ; Mohammadi-Vosough, Elahe ; Misra, Debdipto ; Reza Noorian, Ali ; Nowrouzi-Sohrabi, Peyman ; Paybast, Sepideh ; Poorsaadat, Leila ; Roozbeh, Mehrdad ; Sabayan, Behnam ; Salehizadeh, Saeideh ; Saberi, Alia ; Sepehrnia, Mercedeh ; Vahabizad, Fahimeh ; Yasuda, Thomas Alexandre ; Hojati Marvast, Ahmadreza ; Ghabaee, Mojdeh ; Rahimian, Nasrin ; Harirchian, Mohammad Hossein ; Borhani Haghighi, Afshin ; Arora, Rohan ; Ansari, Saeed ; Avula, Venkatesh ; Li, Jiang ; Abedi, Vida ; Zand, Ramin
Background: Stroke is reported as a consequence of SARS-CoV-2 infection. However, there is a lack of regarding comprehensive stroke phenotype and characteristics
Methods: We conducted a multinational observational study on features of consecutive acute ischemic stroke (AIS), intracranial hemorrhage (ICH), and cerebral venous or sinus thrombosis (CVST) among SARS-CoV-2 infected patients. We further investigated the association of demographics, clinical data, geographical regions, and countries’ health expenditure among AIS patients with the risk of large vessel occlusion (LVO), stroke severity as measured by National Institute of Health stroke scale (NIHSS), and stroke subtype as measured by the TOAST criteria. Additionally, we applied unsupervised machine learning algorithms to uncover possible similarities among stroke patients.
Results: Among the 136 tertiary centers of 32 countries who participated in this study, 71 centers from 17 countries had at least one eligible stroke patient. Out of 432 patients included, 323(74.8%) had AIS, 91(21.1%) ICH, and 18(4.2%) CVST. Among 23 patients with subarachnoid hemorrhage, 16(69.5%) had no evidence of aneurysm. A total of 183(42.4%) patients were women, 104(24.1%) patients were younger than 55 years, and 105(24.4%) patients had no identifiable vascular risk factors. Among 380 patients who had known interval onset of the SARS-CoV-2 and stroke, 144(37.8%) presented to the hospital with chief complaints of stroke-related symptoms, with asymptomatic or undiagnosed SARS-CoV-2 infection. Among AIS patients 44.5% had LVO; 10% had small artery occlusion according to the TOAST criteria. We observed a lower median NIHSS (8[3-17], versus 11 [5-17]; p=0.02) and higher rate of mechanical thrombectomy (12.4% versus 2%; p<0.001) in countries with middle to high-health expenditure when compared to countries with lower health expenditure. The unsupervised machine learning identified 4 subgroups, with a relatively large group with no or limited comorbidities.
Conclusions: We observed a relatively high number of young, and asymptomatic SARS-CoV-2 infections among stroke patients. Traditional vascular risk factors were absent among a relatively large cohort of patients. Among hospitalized patients, the stroke severity was lower and rate of mechanical thrombectomy was higher among countries with middle to high-health expenditure.
Highlights
• 153 chemicals of emerging concern detected in complex multi-component mixtures.
• 108 possible mixture risk assessment scenarios were investigated.
• Non-detects, QSARs, and experimental ecotoxicological data were integrated for risk assessment.
• 8 chemicals were the main risk drivers in at least one site across the River Aconcagua basin.
Abstract
Environmental risk assessments strategies that account for the complexity of exposures are needed in order to evaluate the toxic pressure of emerging chemicals, which also provide suggestions for risk mitigation and management, if necessary. Currently, most studies on the co-occurrence and environmental impacts of chemicals of emerging concern (CECs) are conducted in countries of the Global North, leaving massive knowledge gaps in countries of the Global South.
In this study, we implement a multi-scenario risk assessment strategy to improve the assessment of both the exposure and hazard components in the chemical risk assessment process. Our strategy incorporates a systematic consideration and weighting of CECs that were not detected, as well as an evaluation of the uncertainties associated with Quantitative Structure-Activity Relationships (QSARs) predictions for chronic ecotoxicity. Furthermore, we present a novel approach to identifying mixture risk drivers. To expand our knowledge beyond well-studied aquatic ecosystems, we applied this multi-scenario strategy to the River Aconcagua basin of Central Chile. The analysis revealed that the concentrations of CECs exceeded acceptable risk thresholds for selected organism groups and the most vulnerable taxonomic groups. Streams flowing through agricultural areas and sites near the river mouth exhibited the highest risks. Notably, the eight risk drivers among the 153 co-occurring chemicals accounted for 66–92 % of the observed risks in the river basin. Six of them are pesticides and pharmaceuticals, chemical classes known for their high biological activity in specific target organisms.
Peter, Alina ; Stauch, Benjamin J. ; Shapcott, Katharine A. ; Kouroupaki, Kleopatra ; Schmiedt, Joscha Tapani ; Klein, Liane ; Klon-Lipok, Johanna ; Dowdall, Jarrod Robert ; Schölvinck, Marieke L. ; Vinck, Martin ; Singer, Wolf ; Schmid, Michael Christoph ; Fries, Pascal
When a visual stimulus is repeated, average neuronal responses typically decrease, yet they might maintain or even increase their impact through increased synchronization. Previous work has found that many repetitions of a grating lead to increasing gamma-band synchronization. Here we show in awake macaque area V1 that both, repetition-related reductions in firing rate and increases in gamma are specific to the repeated stimulus. These effects showed some persistence on the timescale of minutes. Further, gamma increases were specific to the presented stimulus location. Importantly, repetition effects on gamma and on firing rates generalized to natural images. These findings suggest that gamma-band synchronization subserves the adaptive processing of repeated stimulus encounters, both for generating efficient stimulus responses and possibly for memory formation.
Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics
(2020)
GABAergic inhibition plays an important role in the establishment and maintenance of cortical circuits during development. Neuregulin 1 (Nrg1) and its interneuron-specific receptor ErbB4 are key elements of a signaling pathway critical for the maturation and proper synaptic connectivity of interneurons. Using conditional deletions of the ERBB4 gene in mice, we tested the role of this signaling pathway at two developmental timepoints in parvalbumin-expressing (PV) interneurons, the largest subpopulation of cortical GABAergic cells. Loss of ErbB4 in PV interneurons during embryonic, but not late postnatal, development leads to alterations in the activity of excitatory and inhibitory cortical neurons, along with severe disruption of cortical temporal organization. These impairments emerge by the end of the second postnatal week, prior to the complete maturation of the PV interneurons themselves. Early loss of ErbB4 in PV interneurons also results in profound dysregulation of excitatory pyramidal neuron dendritic architecture and a redistribution of spine density at the apical dendritic tuft. In association with these deficits, excitatory cortical neurons exhibit normal tuning for sensory inputs, but a loss of state-dependent modulation of the gain of sensory responses. Together these data support a key role for early developmental Nrg1/ErbB4 signaling in PV interneurons as powerful mechanism underlying the maturation of both the inhibitory and excitatory components of cortical circuits.
Blumer, Moritz ; Brown, Thomas ; Freitas, Mariella Bontempo ; Destro, Ana Luiza ; Oliveira, Juraci A. ; Morales, Ariadna E. ; Schell, Tilman ; Greve, Carola ; Pippel, Martin ; Jebb, David ; Hecker, Nikolai ; Ahmed, Alexis-Walid ; Kirilenko, Bogdan M. ; Foote, Maddy ; Janke, Axel ; Lim, Burton K. ; Hiller, Michael
Feeding exclusively on blood, vampire bats represent the only obligate sanguivorous lineage among mammals. To uncover genomic changes associated with adaptations to this unique dietary specialization, we generated a new haplotype-resolved reference-quality genome of the common vampire bat (Desmodus rotundus) and screened 26 bat species for genes that were specifically lost in the vampire bat lineage. We discovered previously-unknown gene losses that relate to metabolic and physiological changes, such as reduced insulin secretion (FFAR1, SLC30A8), limited glycogen stores (PPP1R3E), and a distinct gastric physiology (CTSE). Other gene losses likely reflect the biased nutrient composition (ERN2, CTRL) and distinct pathogen diversity of blood (RNASE7). Interestingly, the loss of REP15 likely helped vampire bats to adapt to high dietary iron levels by enhancing iron excretion and the loss of the 24S-hydroxycholesterol metabolizing enzyme CYP39A1 could contribute to their exceptional cognitive abilities. Finally, losses of key cone phototransduction genes (PDE6H, PDE6C) suggest that these strictly-nocturnal bats completely lack cone-based vision. These findings enhance our understanding of vampire bat biology and the genomic underpinnings of adaptations to sanguivory.
Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder
(2021)
Konrad, Kerstin ; Kohls, Gregor ; Baumann, Sarah ; Bernhard, Anka ; Martinelli, Anne ; Ackermann, Katharina ; Smaragdi, Areti ; Gonzalez-Madruga, Karen ; Wells, Amy ; Rogers, Jack C. ; Pauli, Ruth ; Clanton, Roberta ; Baker, Rosalind ; Kersten, Linda ; Prätzlich, Martin ; Oldenhof, Helena ; Jansen, Lucres ; Kleeven, Anneke ; Bigorra, Aitana ; Hervás, Amaia ; Kerexeta-Lizeaga, Iñaki ; Sesma-Pardo, Eva ; Gonzalez-Torres, Miguel Angel ; Siklósi, Réka ; Dochnal, Roberta ; Kalogerakis, Zacharias ; Pirlympou, Mara ; Papadakos, Leonidas ; Cornwell, Harriet ; Scharke, Wolfgang ; Dikeos, Dimitris ; Fernández-Rivas, Aranzazu ; Popma, Arne ; Stadler, Christina ; Herpertz-Dahlmann, Beate ; De Brito, Stephane A. ; Fairchild, Graeme ; Freitag, Christine M.
Background: Conduct disorder (CD) rarely occurs alone but is typically accompanied by comorbid psychiatric disorders, which complicates the clinical presentation and treatment of affected youths. The aim of this study was to investigate sex differences in comorbidity pattern in CD and to systematically explore the ‘gender paradox’ and ‘delayed-onset pathway’ hypotheses of female CD.
Methods: As part of the FemNAT-CD multisite study, semistructured clinical interviews and rating scales were used to perform a comprehensive phenotypic characterization of 454 girls and 295 boys with CD (9–18 years), compared to 864 sex- and age-matched typically developing controls.
Results: Girls with CD exhibited higher rates of current major depression, anxiety disorders, post-traumatic stress disorder and borderline personality disorder, whereas boys with CD had higher rates of current attention-deficit/hyperactivity disorder. In line with the ‘gender paradox’ hypothesis, relative to boys, girls with CD showed significantly more lifetime psychiatric comorbidities (incl. Alcohol Use Disorder), which were accompanied by more severe CD symptoms. Female and male youths with CD also differed significantly in their CD symptom profiles and distribution of age-of-onset subtypes of CD (i.e. fewer girls with childhood-onset CD). In line with the ‘delayed-onset pathway’ hypothesis, girls with adolescent-onset CD showed similar levels of dimensional psychopathology like boys with childhood-onset CD, while boys with adolescent-onset CD had the lowest levels of internalizing psychopathology.
Conclusions: Within the largest study of CD in girls performed to date, we found compelling evidence for sex differences in comorbidity patterns and clinical presentation of CD. Our findings further support aspects of the ‘gender paradox’ and ‘delayed-onset pathway’ hypotheses by showing that girls with CD had higher rates of comorbid lifetime mental disorders and functional impairments, and they usually developed CD during adolescence. These novel data on sex-specific clinical profiles of CD will be critical in informing intervention and prevention programmes.