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We study the processes e+e−→K0SD+sD∗− and e+e−→K0SD∗+sD−, as well as their charge conjugated processes, at five center-of-mass energies between 4.628~GeV and 4.699~GeV, using data samples corresponding to an integrated luminosity of 3.8 fb−1 collected by the BESIII detector at the BEPCII storage ring. Based on a partial reconstruction technique, we find evidence of a structure near the thresholds for D+sD∗− and D∗+sD− production in the K0S recoil-mass spectrum, which we refer to as the Zcs(3985)0. Fitting with a Breit-Wigner line shape, we find the mass of the structure to be (3992.2±1.7±1.6) MeV/c2 and the width to be (7.7+4.1−3.8±4.3) MeV, where the first uncertainties are statistical and the second are systematic. The significance of the Zcs(3985)0 signal is found to be 4.6σ including both the statistical and systematic uncertainty. We report the Born cross section multiplied by the branching fraction at different energy points. The mass of the Zcs(3985)0 is close to that of the Zcs(3985)+. Assuming SU(3) symmetry, the cross section of the neutral channel is consistent with that of the charged one. Hence, we conclude that the Zcs(3985)0 is the isospin partner of the Zcs(3985)+.
Using a sample of 4.3×105 η′→ηπ0π0 events selected from the ten billion J/ψ event dataset collected with the BESIII detector, we study the decay η′→ηπ0π0 within the framework of nonrelativistic effective field theory. Evidence for a structure at π+π− mass threshold is observed in the invariant mass spectrum of π0π0 with a statistical significance of around 3.5σ, which is consistent with the cusp effect as predicted by the nonrelativistic effective field theory. After introducing the amplitude for describing the cusp effect, the ππ scattering length combination a0−a2 is determined to be 0.226±0.060stat±0.013syst, which is in good agreement with theoretical calculation of 0.2644±0.0051.
We study the hadronic decays of Λ+c to the final states Σ+η and Σ+η′, using an e+e− annihilation data sample of 567 pb−1 taken at a center-of-mass energy of 4.6 GeV with the BESIII detector at the BEPCII collider. We find evidence for the decays Λ+c→Σ+η and Σ+η′ with statistical significance of 2.5σ and 3.2σ, respectively. Normalizing to the reference decays Λ+c→Σ+π0 and Σ+ω, we obtain the ratios of the branching fractions B(Λ+c→Σ+η)B(Λ+c→Σ+π0) and B(Λ+c→Σ+η′)B(Λ+c→Σ+ω) to be 0.35±0.16±0.03 and 0.86±0.34±0.07, respectively. The upper limits at the 90\% confidence level are set to be B(Λ+c→Σ+η)B(Λ+c→Σ+π0)<0.58 and B(Λ+c→Σ+η′)B(Λ+c→Σ+ω)<1.2. Using BESIII measurements of the branching fractions of the reference decays, we determine B(Λ+c→Σ+η)=(0.41±0.19±0.05)% (<0.68%) and B(Λ+c→Σ+η′)=(1.34±0.53±0.21)% (<1.9%). Here, the first uncertainties are statistical and the second systematic. The obtained branching fraction of Λ+c→Σ+η is consistent with the previous measurement, and the branching fraction of Λ+c→Σ+η′ is measured for the first time.
The decay 𝜂𝑐(2𝑆)→𝜋+𝜋−𝜂 is searched for through the radiative transition 𝜓(3686)→𝛾𝜂𝑐(2𝑆) using 448 million 𝜓(3686) events accumulated at the BESIII detector. The first evidence of 𝜂𝑐(2𝑆)→𝜋+𝜋−𝜂 is found with a statistical significance of 3.5𝜎. The product of the branching fractions of 𝜓(3686)→𝛾𝜂𝑐(2𝑆) and 𝜂𝑐(2𝑆)→𝜋+𝜋−𝜂 is measured to be Br(𝜓(3686)→𝛾𝜂𝑐(2𝑆))×Br(𝜂𝑐(2𝑆)→𝜋+𝜋−𝜂)=(2.97±0.81±0.26)×10−6, where the first uncertainty is statistical and the second one is systematic. The branching fraction of the decay 𝜂𝑐(2𝑆)→𝜋+𝜋−𝜂 is determined to be Br(𝜂𝑐(2𝑆)→𝜋+𝜋−𝜂)=(42.4±11.6±3.8±30.3)×10−4, where the third uncertainty is transferred from the uncertainty of the branching fraction of 𝜓(3686)→𝛾𝜂𝑐(2𝑆).
Background: Cannabinoid receptor 1 (CB1) is expressed in certain types of malignancies. An analysis of CB1 expression and function in Hodgkin lymphoma (HL), one of the most frequent lymphomas, was not performed to date.
Design and Methods: We examined the distribution of CB1 protein in primary cases of HL. Using lymphoma derived cell lines, the role of CB1 signaling on cell survival was investigated.
Results: A predominant expression of CB1 was found in Hodgkin-Reed-Sternberg cells in a vast majority of classical HL cases. The HL cell lines L428, L540 and KM-H2 showed strong CB1-abundance and displayed a dose-dependent decline of viability under CB1 inhibition with AM251. Further, application of AM251 led to decrease of constitutively active NFκB/p65, a crucial survival factor of HRS-cells, and was followed by elevation of apoptotic markers in HL cells.
Conclusions: The present study identifies CB1 as a feature of HL, which might serve as a potential selective target in the treatment of Hodgkin lymphoma.
This paper reports on Monte Carlo simulation results for future measurements of the moduli of time-like proton electromagnetic form factors, |GE | and |GM|, using the ¯pp → μ+μ− reaction at PANDA (FAIR). The electromagnetic form factors are fundamental quantities parameterizing the electric and magnetic structure of hadrons. This work estimates the statistical and total accuracy with which the form factors can be measured at PANDA, using an analysis of simulated data within the PandaRoot software framework. The most crucial background channel is ¯pp → π+π−,due to the very similar behavior of muons and pions in the detector. The suppression factors are evaluated for this and all other relevant background channels at different values of antiproton beam momentum. The signal/background separation is based on a multivariate analysis, using the Boosted Decision Trees method. An expected background subtraction is included in this study, based on realistic angular distribuations of the background contribution. Systematic uncertainties are considered and the relative total uncertainties of the form factor measurements are presented.
The first direct measurement of the absolute branching fraction of Σ+→Λe+νe is reported based on an e+e− annihilation sample of (10087±44)×106 J/ψ events collected with the BESIII detector at s√=3.097 GeV. The branching fraction is determined to be B(Σ+→Λe+νe)=[2.93±0.74(stat)±0.13(syst)]×10−5, which is the most precise measurement obtained in a single experiment to date and also the first result obtained at a collider experiment. Combining this result with the world average of B(Σ−→Λe−ν¯e) and the lifetimes of Σ±, the ratio, Γ(Σ−→Λe−ν¯e)Γ(Σ+→Λe+νe), is determined to be 1.06±0.28, which is within 1.8 standard deviations of the value expected in the absence of second-class currents that are forbidden in the Standard Model.
Using 7.33 fb−1 of e+e− collision data taken with the BESIII detector at the BEPCII collider, we report the first experimental study of the purely leptonic decay D∗+s→e+νe. A signal for the decay D∗+s→e+νe is observed with a statistical significance of 2.9σ. The branching fraction of D∗+s→e+νe is measured to be (2.1+1.2−0.9stat.±0.2syst.)×10−5, corresponding to an upper limit of 4.0×10−5 at the 90\% confidence level. Taking the total width of the D∗+s~((0.070±0.028) keV) predicted by lattice quantum chromodynamics as input, the decay constant of the D∗+s is determined to be fD∗+s=(213.6+61.0−45.8stat.±43.9syst.) MeV, corresponding to an upper limit of 353.8 MeV at the 90\% confidence level.
he process e+e−→pK0Sn¯K−+c.c. and its intermediate processes are studied for the first time, using data samples collected with the BESIII detector at BEPCII at center-of-mass energies of 3.773, 4.008, 4.226, 4.258, 4.358, 4.416, and 4.600 GeV, with a total integrated luminosity of 7.4 fb−1. The Born cross section of e+e−→pK0Sn¯K−+c.c. is measured at each center-of-mass energy, but no significant resonant structure in the measured cross-section line shape between 3.773 and 4.600 GeV is observed. No evident structure is detected in the pK−, nK0S, pK0S, nK+, pn¯, or K0SK− invariant mass distributions except for Λ(1520). The Born cross sections of e+e−→Λ(1520)n¯K0S+c.c. and e+e−→Λ(1520)p¯K++c.c. are measured, and the 90\% confidence level upper limits on the Born cross sections of e+e−→Λ(1520)Λ¯(1520) are determined at the seven center-of-mass energies.
Using a data sample corresponding to an integrated luminosity of 2.93 fb−1 collected at a center-of-mass energy √𝑠=3.773 GeV by the BESIII detector, the decay 𝐷0→𝜔𝜙 is observed for the first time. The branching fraction is measured to be (6.48±0.96±0.40)×10−4 with a significance of 6.3𝜎, where the first and second uncertainties are statistical and systematic, respectively. An angular analysis reveals that the 𝜙 and 𝜔 mesons from the 𝐷0→𝜔𝜙 decay are transversely polarized. The 95% confidence level upper limit on longitudinal polarization fraction is set to be less than 0.24, which is inconsistent with current theoretical expectations and challenges our understanding of the underlying dynamics in charm meson decays.
he absolute branching fraction of Λ→pμ−ν¯μ is reported for the first time based on an e+e− annihilation sample of ten billion J/ψ events collected with the BESIII detector at s√=3.097 GeV. The branching fraction is determined to be B(Λ→pμ−ν¯μ)=[1.48±0.21(stat)±0.08(syst)]×10−4, which is a significant improvement in precision over the previous indirect measurements. Combining this result with the world average of B(Λ→pe−ν¯e), we obtain the ratio, Γ(Λ→pμ−ν¯μ)Γ(Λ→pe−ν¯e), to be 0.178±0.028, which agrees with the standard model prediction assuming lepton flavor universality. The asymmetry of the branching fractions of Λ→pμ−ν¯μ and Λ¯→p¯μ+νμ is also determined, and no evidence for CP violation is found.
We report on new measurements of Cabibbo-suppressed semileptonic D+s decays using 3.19 fb−1 of e+e− annihilation data sample collected at a center-of-mass energy of 4.178~GeV with the BESIII detector at the BEPCII collider. Our results include branching fractions B(D+s→K0e+νe)=(3.25±0.38(stat.)±0.16(syst.))×10−3 and B(D+s→K∗0e+νe)=(2.37±0.26(stat.)±0.20(syst.))×10−3 which are much improved relative to previous measurements, and the first measurements of the hadronic form-factor parameters for these decays. For D+s→K0e+νe, we obtain f+(0)=0.720±0.084(stat.)±0.013(syst.), and for D+s→K∗0e+νe, we find form-factor ratios rV=V(0)/A1(0)=1.67±0.34(stat.)±0.16(syst.) and r2=A2(0)/A1(0)=0.77±0.28(stat.)±0.07(syst.).
We measured the branching fractions of the decays χcJ→Σ−Σ¯+ for the first time using the final states nn¯π+π−. The data sample exploited here is 448.1×106 ψ(3686) events collected with BESIII. We find B(χcJ→Σ−Σ¯+)=(51.3±2.4±4.1)×10−5,(5.7±1.4±0.6)×10−5,and (4.4±1.7±0.5)×10−5, for J=0,1,2, respectively, where the first uncertainties are statistical and the second systematic.
By analyzing a data sample corresponding to an integrated luminosity of 2.93 fb−1 collected at a center-of-mass energy of 3.773 GeV with By analyzing a data sample corresponding to an integrated luminosity of 2.93 fb−1 collected at a center-of-mass energy of 3.773 GeV with the BESIII detector, we measure for the first time the absolute branching fraction of the 𝐷+→𝜂𝜇+𝜈𝜇 decay to be ℬ𝐷+→𝜂𝜇+𝜈𝜇=(10.4±1.0stat±0.5syst)×10−4. Using the world averaged value of ℬ𝐷+→𝜂𝑒+𝜈𝑒, the ratio of the two branching fractions is determined to be ℬ𝐷+→𝜂𝜇+𝜈𝜇/ℬ𝐷+→𝜂𝑒+𝜈𝑒=0.91±0.13(stat+syst), which agrees with the theoretical expectation of lepton flavor universality within uncertainty. By studying the differential decay rates in five four-momentum transfer intervals, we obtain the product of the hadronic form factor 𝑓𝜂+(0) and the 𝑐→𝑑 Cabibbo-Kobayashi-Maskawa matrix element |𝑉𝑐𝑑| to be 𝑓𝜂+(0)|𝑉𝑐𝑑|=0.087±0.008stat±0.002syst. Taking the input of |𝑉𝑐𝑑| from the global fit in the standard model, we determine 𝑓𝜂+(0)=0.39±0.04stat±0.01syst. On the other hand, using the value of 𝑓𝜂+(0) calculated in theory, we find |𝑉𝑐𝑑| = 0.242±0.022stat±0.006syst±0.033theory.
We study the direct production of the JPC=1++ charmonium state χc1(1P) in electron-positron annihilation by carrying out an energy scan around the mass of the χc1(1P). The data were collected with the BESIII detector at the BEPCII collider. An interference pattern between the signal process e+e−→χc1(1P)→γJ/ψ→γμ+μ− and the background processes e+e−→γISRJ/ψ→γISRμ+μ− and e+e−→γISRμ+μ− are observed by combining all the data samples. The χc1(1P) signal is observed with a significance of 5.1σ. This is the first observation of a C-even state directly produced in e+e− annihilation. The electronic width of the χc1(1P) resonance is determined to be Γee=(0.12+0.13−0.08) eV, which is of the same order of magnitude as theoretical calculations.
Using 4.5 fb−1 of e+e− annihilation data samples collected at the center-of-mass energies ranging from 4.600~GeV to 4.699~GeV with the BESIII detector at the BEPCII collider, a first study of the semileptonic decays Λ+c→pK−e+νe, Λ+c→Λ(1520)e+νe and Λ+c→Λ(1405)e+νe is performed. The Λ+c→pK−e+νe decay is observed with a significance of 8.2σ and the branching fraction is measured to be B(Λ+c→pK−e+νe)=(0.88±0.17stat.±0.07syst.)×10−3. We also report evidence of Λ+c→Λ(1520)e+νe and Λ+c→Λ(1405)e+νe with significances of 3.3σ and 3.2σ, respectively, and measure B(Λ+c→Λ(1520)e+νe)=(1.02±0.52stat.±0.11syst.)×10−3 and B(Λ+c→Λ(1405)[→pK−]e+νe)=(0.42±0.19stat.±0.04syst.)×10−3. Combining these with the inclusive semileptonic Λ+c branching fraction measured by BESIII, the relative fraction is determined to be [B(Λ+c→pK−e+νe)/B(Λ+c→Xe+νe)]=(2.1±0.4stat.±0.2syst.)%, which provides a clear confirmation that semileptonic Λ+c decays are not saturated by the Λℓ+νℓ final state.
The Ξ0 asymmetry parameters are measured using entangled quantum Ξ0 − Ξ¯ 0 pairs from a sample of ð448.1 2.9Þ × 106 ψð3686Þ events collected with the BESIII detector at BEPCII. The relative phase between the transition amplitudes of the Ξ0Ξ¯ 0 helicity states is measured to be ΔΦ ¼ −0.050 0.150 0.020 rad, which implies that there is no obvious polarization at the current level of statistics. The decay parameters of the Ξ0 hyperon ðαΞ0 ; αΞ¯ 0 ; ϕΞ0 ; ϕΞ¯ 0 Þ and the angular distribution parameter ½αψð3686Þ and ΔΦ are measured simultaneously for the first time. In addition, the CP asymmetry observables are determined to be AΞ0 CP ¼ ðαΞ0 þ αΞ¯ 0 Þ=ðαΞ0 − αΞ¯ 0 Þ ¼ −0.007 0.082 0.025 and ΔϕΞ0 CP ¼ ðϕΞ0 þ ϕΞ¯ 0 Þ=2 ¼ −0.079 0.082 0.010 rad, which are consistent with CP conservation.