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The Gottfried sum-rule violation reported by the New Muon Collaboration was interpreted as an indication for a flavor asymmetry of the sea quark in the nucleon. We investigate the alternative possibility that isospin symmetry between the proton and the neutron is breaking. We examine systematically the consequences of this possibility for several processes, namely, neutrino deep inelastic scattering, the charged pion Drell-Yan process, the proton Drell-Yan process, and semi-inclusive deep inelastic scattering, and conclude that a decision between the two alternative explanations is possible.
A new spontaneous-symmetry-breaking mechanism is formulated for SU(3), which is used to describe the formation of bags around quarks. The Higgs field is replaced by the scalar product of two colored fermion fields. This model gives mass only to one gluon (equivalent to Aμ8) when spontaneously broken. The consequences of this scheme are discussed, and it is argued that it can explain several puzzling high-energy heavy-ion experiments.
Phenomenological consequences of a hypothetical light neutral particle in heavy ion collisions
(1986)
We discuss the possibility that the line structure observed in the spectrum of the positrons produced in heavy ion collisions is due to the decay of a new neutral elementary particle. We argue that this can be ruled out unless one is willing to accept fine tuning of parameters, or to assume the dominance of nonlinear effects.
We have investigated the channeling process of charged particles in a bent crystal. Invoking simple assumptions we derive a criterion, which determines whether channeling occurs or not. We obtain the same criterion using the Dirac equation. It is shown that the centrifugal force acting on the particle in the bent crystal significantly alters the effective transverse potential. The cases of axial and planar channeling are considered. The channeling probability and the dechanneling probability due to tunneling of the particle under the barrier in the effective transverse potential are estimated. These probabilities depend on the specific scaling parameter characterizing the process. Using the quasiclassical theory of synchrotron radiation we have calculated the contribution to the radiation spectrum, which arises due to the curvature of the channel. This contribution becomes significant to TeV electrons or positrons. Some practical consequences of our results are briefly discussed.
An alternative theoretical description of axial electron channeling in the multi-GeV region has been developed. We solve a kinetic equation to evaluate an electron distribution function in axially oriented single crystals. Based on the single-string model, the required matrix elements for radiation and scattering by lattice vibrations are calculated employing solutions of the Dirac equation in cylindrical coordinates. Results obtained for 150-GeV electrons propagating along the <110> axis of germanium are in good agreement with experimental observations.
We investigate the possibility that high-energy photons are channeled, when passing through an oriented single crystal, due to Delbrück scattering. For this purpose the exact electron propagator for the single-string model is constructed. Starting from a separation of variables, we solve the Dirac equation for a cylindrical electrostatic potential. The propagator for such external fields is constructed from solutions of the radial Dirac equation. This propagator is applied to a calculation of the S matrix for Delbrück scattering. We specify the conditions under which photon channeling takes place. Unfortunately these conditions are only matched for a very small fraction of those photons being produced by channeled electrons.
The electron-positron pairs observed in heavy-ion collisions at Gesellschaft für Schwerionen-forschung Darmstadt mbH have been interpreted as the decay products of yet unknown particles with masses around 1.8 MeV. The negative results of resonant Bhabha scattering experiments, however, do not support such an interpretation. Therefore we focus on a more complex decay scenario, where the e+e- lines result from a two-collision process. We discuss the induced decay of a metastable 1++ state into e+e- pairs. For most realizations of a 1++ state such a decay in leading order can only take place in the Coulomb field of a target atom. This fact has the attractive consequence that for such a state the Bhabha bounds are no longer valid. However, the absolute value of the e+e- production cross section turns out to be unacceptably small.
Intrahepatic cholangiocarcinoma (iCCA) is the most frequent subtype of cholangiocarcinoma (CCA), and the incidence has globally increased in recent years. In contrast to surgically treated iCCA, data on the impact of fibrosis on survival in patients undergoing palliative chemotherapy are missing. We retrospectively analyzed the cases of 70 patients diagnosed with iCCA between 2007 and 2020 in our tertiary hospital. Histopathological assessment of fibrosis was performed by an expert hepatobiliary pathologist. Additionally, the fibrosis-4 score (FIB-4) was calculated as a non-invasive surrogate marker for liver fibrosis. For overall survival (OS) and progression-free survival (PFS), Kaplan–Meier curves and Cox-regression analyses were performed. Subgroup analyses revealed a median OS of 21 months (95% CI = 16.7–25.2 months) and 16 months (95% CI = 7.6–24.4 months) for low and high fibrosis, respectively (p = 0.152). In non-cirrhotic patients, the median OS was 21.8 months (95% CI = 17.1–26.4 months), compared with 9.5 months (95% CI = 4.6–14.3 months) in cirrhotic patients (p = 0.007). In conclusion, patients with iCCA and cirrhosis receiving palliative chemotherapy have decreased OS rates, while fibrosis has no significant impact on OS or PFS. These patients should not be prevented from state-of-the-art first-line chemotherapy.
Resilience has been defined as the maintenance or quick recovery of mental health during and after times of adversity. How to operationalize resilience and to determine the factors and processes that lead to good long-term mental health outcomes in stressor-exposed individuals is a matter of ongoing debate and of critical importance for the advancement of the field. One of the biggest challenges for implementing an outcome-based definition of resilience in longitudinal observational study designs lies in the fact that real-life adversity is usually unpredictable and that its substantial qualitative as well as temporal variability between subjects often precludes defining circumscribed time windows of inter-individually comparable stressor exposure relative to which the maintenance or recovery of mental health can be determined. To address this pertinent issue, we propose to frequently and regularly monitor stressor exposure (E) and mental health problems (P) throughout a study's observation period [Frequent Stressor and Mental Health Monitoring (FRESHMO)-paradigm]. On this basis, a subject's deviation at any single monitoring time point from the study sample's normative E–P relationship (the regression residual) can be used to calculate that subject's current mental health reactivity to stressor exposure (“stressor reactivity,” SR). The SR score takes into account the individual extent of experienced adversity and is comparable between and within subjects. Individual SR time courses across monitoring time points reflect intra-individual temporal variability in SR, where periods of under-reactivity (negative SR score) are associated with accumulation of fewer mental health problems than is normal for the sample. If FRESHMO is accompanied by regular measurement of potential resilience factors, temporal changes in resilience factors can be used to predict SR time courses. An increase in a resilience factor measurement explaining a lagged decrease in SR can then be considered to index a process of adaptation to stressor exposure that promotes a resilient outcome (an allostatic resilience process). This design principle allows resilience research to move beyond merely determining baseline predictors of resilience outcomes, which cannot inform about how individuals successfully adjust and adapt when confronted with adversity. Hence, FRESHMO plus regular resilience factor monitoring incorporates a dynamic-systems perspective into resilience research.
Comparative proteomics reveals a diagnostic signature for pulmonary head‐and‐neck cancer metastasis
(2018)
Patients with head‐and‐neck cancer can develop both lung metastasis and primary lung cancer during the course of their disease. Despite the clinical importance of discrimination, reliable diagnostic biomarkers are still lacking. Here, we have characterised a cohort of squamous cell lung (SQCLC) and head‐and‐neck (HNSCC) carcinomas by quantitative proteomics. In a training cohort, we quantified 4,957 proteins in 44 SQCLC and 30 HNSCC tumours. A total of 518 proteins were found to be differentially expressed between SQCLC and HNSCC, and some of these were identified as genetic dependencies in either of the two tumour types. Using supervised machine learning, we inferred a proteomic signature for the classification of squamous cell carcinomas as either SQCLC or HNSCC, with diagnostic accuracies of 90.5% and 86.8% in cross‐ and independent validations, respectively. Furthermore, application of this signature to a cohort of pulmonary squamous cell carcinomas of unknown origin leads to a significant prognostic separation. This study not only provides a diagnostic proteomic signature for classification of secondary lung tumours in HNSCC patients, but also represents a proteomic resource for HNSCC and SQCLC.