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Three experiments investigated the interpretation and production of pronouns in German. The first two experiments probed the preferred interpretation of a pronoun in contexts containing two potential antecedents by having participants complete a sentence fragment starting either with a personal pronoun or a d-pronoun. We systematically varied three properties of the potential antecedents: syntactic function, linear position, and topicality. The results confirm a subject preference for personal pronouns. The preferred interpretation of d-pronouns cannot be captured by any of the three factors alone. Although a d-pronoun preferentially refers to the non-topic in many cases, this preference can be overridden by the other two factors, linear position and syntactic function. In order to test whether interpretive preferences follow from production biases as proposed by the Bayesian theory of Kehler et al. (2008), a third experiment had participants freely produce a continuation sentence for the contexts of the first two experiments. The results show that personal pronouns are used more often to refer to a subject than to an object, recapitulating the subject preference found for interpretation and thereby confirming the account of Kehler et al. (2008). The interpretation results for the d-pronoun likewise follow from the corresponding production data.
Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs.
Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel.
Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy.
Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment.