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Militarization, factionalism and political transitions: an inquiry into the causes of state collapse
(2020)
Why do some fragile states collapse while others do not? This article presents results from a comparative analysis of the causes of state collapse. Using a dataset of 15 cases of state collapse between 1960 and 2007, we conduct both synchronic and diachronic comparisons with two different control groups of fragile states using crisp-set QCA. The results support our hypothesis that state collapse has multiple causes. The militarization of political groups, when combined with other conditions, plays a major part in the process. Other causal factors are political transition, extreme poverty, declining government resources or external aid, factionalist politics, repression and pre-colonial polities. This challenges structuralist explanations focusing on regime types and the resource curse, among other things, and opens up avenues for further research.
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.