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The decay D→K−π+ is studied in a sample of quantum-correlated DD¯ pairs, based on a data set corresponding to an integrated luminosity of 2.93\,fb−1 collected at the ψ(3770) resonance by the BESIII experiment. The asymmetry between CP-odd and CP-even eigenstate decays into K−π+ is determined to be AKπ=0.132±0.011±0.007, where the first uncertainty is statistical and the second is systematic. This measurement is an update of an earlier study exploiting additional tagging modes, including several decay modes involving a K0L meson. The branching fractions of the K0L modes are determined as input to the analysis in a manner that is independent of any strong phase uncertainty. Using the predominantly CP-even tag D→π+π−π0 and the ensemble of CP-odd eigenstate tags, the observable Aπππ0Kπ is measured to be 0.130±0.012±0.008. The two asymmetries are sensitive to rKπDcosδKπD, where rKπD and δKπD are the ratio of amplitudes and phase difference, respectively, between the doubly Cabibbo-suppressed and Cabibbo-favoured decays. In addition, events containing D→K−π+ tagged by D→K0S,Lπ+π− are studied in bins of phase space of the three-body decays. This analysis has sensitivity to both rKπDcosδKπD and rKπDsinδKπD. A fit to AKπ, Aπππ0Kπ and the phase-space distribution of the D→K0S,Lπ+π− tags yields δKπD=(187.6+8.9−9.7+5.4−6.4) degrees, where external constraints are applied for rKπD and other relevant parameters. This is the most precise measurement of δKπD in quantum-correlated DD¯ decays.
Using (447.9 ± 2.3) million ψ(3686) events collected with the BESIII detector, the decays of χcJ→ϕϕ (J=0, 1, 2) have been studied via the decay ψ(3686)→γχcJ. The branching fractions of the decays χcJ→ϕϕ (J=0, 1, 2) are determined to be (8.48±0.26±0.27)×10−4, (4.36±0.13±0.18)×10−4, and (13.36±0.29±0.49)×10−4, respectively, which are the most precise measurements to date. From a helicity amplitude analysis of the process ψ(3686)→γχcJ,χcJ→ϕϕ,ϕ→K+K−, the polarization parameters of the χcJ→ϕϕ decays are determined for the first time.
Using 9.9 fb−1 of e+e− collision data collected by the BESIII detector at center-of-mass energies between 4.15 and 4.30 GeV, we search for the processes e+e−→γX(3872) with X(3872)→π0χc0 and X(3872)→ππχc0. Depending on the fitting model, the statistical significance for X(3872)→π0χc0 ranges from 1.3σ to 2.8σ. We set upper limits (at 90\% C.L.) of B(X(3872)→π0χc0)B(X(3872)→π+π−J/ψ)<3.6, B(X(3872)→π+π−χc0)B(X(3872)→π+π−J/ψ)<0.68, and B(X(3872)→π0π0χc0)B(X(3872)→π+π−J/ψ)<1.7. Combined with the BESIII measurement of X(3872)→π0χc1, we also set an upper limit of B(X(3872)→π0χc0)B(X(3872)→π0χc1)<4.4.
Using 9.9 fb−1 of e+e− collision data collected by the BESIII detector at center-of-mass energies between 4.15 and 4.30 GeV, we search for the processes e+e−→γX(3872) with X(3872)→π0χc0 and X(3872)→ππχc0. Depending on the fitting model, the statistical significance for X(3872)→π0χc0 ranges from 1.3σ to 2.8σ. We set upper limits (at 90\% C.L.) of B(X(3872)→π0χc0)B(X(3872)→π+π−J/ψ)<3.6, B(X(3872)→π+π−χc0)B(X(3872)→π+π−J/ψ)<0.68, and B(X(3872)→π0π0χc0)B(X(3872)→π+π−J/ψ)<1.7. Combined with the BESIII measurement of X(3872)→π0χc1, we also set an upper limit of B(X(3872)→π0χc0)B(X(3872)→π0χc1)<4.4.
Using 9.9 fb−1 of e+e− collision data collected by the BESIII detector at center-of-mass energies between 4.15 and 4.30 GeV, we search for the processes e+e−→γX(3872) with X(3872)→π0χc0 and X(3872)→ππχc0. Depending on the fitting model, the statistical significance for X(3872)→π0χc0 ranges from 1.3σ to 2.8σ. We set upper limits (at 90\% C.L.) of B(X(3872)→π0χc0)B(X(3872)→π+π−J/ψ)<3.6, B(X(3872)→π+π−χc0)B(X(3872)→π+π−J/ψ)<0.68, and B(X(3872)→π0π0χc0)B(X(3872)→π+π−J/ψ)<1.7. Combined with the BESIII measurement of X(3872)→π0χc1, we also set an upper limit of B(X(3872)→π0χc0)B(X(3872)→π0χc1)<4.4.
Using 4.5 fb−1 of e+e− annihilation data samples collected at the center-of-mass energies ranging from 4.600~GeV to 4.699~GeV with the BESIII detector at the BEPCII collider, a first study of the semileptonic decays Λ+c→pK−e+νe, Λ+c→Λ(1520)e+νe and Λ+c→Λ(1405)e+νe is performed. The Λ+c→pK−e+νe decay is observed with a significance of 8.2σ and the branching fraction is measured to be B(Λ+c→pK−e+νe)=(0.88±0.17stat.±0.07syst.)×10−3. We also report evidence of Λ+c→Λ(1520)e+νe and Λ+c→Λ(1405)e+νe with significances of 3.3σ and 3.2σ, respectively, and measure B(Λ+c→Λ(1520)e+νe)=(1.02±0.52stat.±0.11syst.)×10−3 and B(Λ+c→Λ(1405)[→pK−]e+νe)=(0.42±0.19stat.±0.04syst.)×10−3. Combining these with the inclusive semileptonic Λ+c branching fraction measured by BESIII, the relative fraction is determined to be [B(Λ+c→pK−e+νe)/B(Λ+c→Xe+νe)]=(2.1±0.4stat.±0.2syst.)%, which provides a clear confirmation that semileptonic Λ+c decays are not saturated by the Λℓ+νℓ final state.
Using a sample of 4.3×105 η′→ηπ0π0 events selected from the 10 billion J/ψ event data set collected with the BESIII detector, we study the decay η′→ηπ0π0 within the framework of non-relativistic effective field theory. Evidence for a structure at π+π− mass threshold is observed in the invariant mass spectrum of π0π0 with a statistical significance of around 3.5σ, which is consistent with the cusp effect as predicted by the non-relativistic effective field theory. After introducing the amplitude for describing the cusp effect, the ππ scattering length combination a0−a2 is determined to be 0.226±0.060stat.±0.012syst., which is in good agreement with theoretical calculation of 0.2644±0.0051.
Using a sample of 4.3×105 η′→ηπ0π0 events selected from the ten billion J/ψ event dataset collected with the BESIII detector, we study the decay η′→ηπ0π0 within the framework of nonrelativistic effective field theory. Evidence for a structure at π+π− mass threshold is observed in the invariant mass spectrum of π0π0 with a statistical significance of around 3.5σ, which is consistent with the cusp effect as predicted by the nonrelativistic effective field theory. After introducing the amplitude for describing the cusp effect, the ππ scattering length combination a0−a2 is determined to be 0.226±0.060stat±0.013syst, which is in good agreement with theoretical calculation of 0.2644±0.0051.
Using a sample of 4.3×105 η′→ηπ0π0 events selected from the ten billion J/ψ event dataset collected with the BESIII detector, we study the decay η′→ηπ0π0 within the framework of nonrelativistic effective field theory. Evidence for a structure at π+π− mass threshold is observed in the invariant mass spectrum of π0π0 with a statistical significance of around 3.5σ, which is consistent with the cusp effect as predicted by the nonrelativistic effective field theory. After introducing the amplitude for describing the cusp effect, the ππ scattering length combination a0−a2 is determined to be 0.226±0.060stat±0.013syst, which is in good agreement with theoretical calculation of 0.2644±0.0051.
The study of the Cabibbo-favored semileptonic decay Λ+𝑐→Λ𝑒+𝜈𝑒 is reported using a 4.5 fb−1 data sample of 𝑒+𝑒− annihilations collected at center-of-mass energies ranging from 4.600 GeV to 4.699 GeV with the BESIII detector at the BEPCII collider. The branching fraction of the decay is measured to be ℬ(Λ+𝑐→Λ𝑒+𝜈𝑒)=(3.56±0.11stat±0.07syst)%, which is the most precise measurement to date. Furthermore, we perform an investigation of the internal dynamics in Λ+𝑐→Λ𝑒+𝜈𝑒. We provide the first direct comparisons of the differential decay rate and form factors with those predicted from lattice quantum chromodynamics (LQCD) calculations. Combining the measured branching fraction with a 𝑞2-integrated rate predicted by LQCD, we determine 𝑉𝑐𝑠|=0.936±0.017ℬ±0.024LQCD±0.007𝜏Λ𝑐.
Based on a sample of 4.4 fb−1 of e+e− annihilation data collected in the energy region between 4.6 GeV and 4.7 GeV with the BESIII detector at BEPCII, two singly Cabibbo-suppressed decays Λ+c→Σ0K+ and Λ+c→Σ+K0S are studied. The ratio of the branching fraction B(Λ+c→Σ0K+) relative to B(Λ+c→Σ0π+) is measured to be 0.0361±0.0073(stat.)±0.0005(syst.), and the ratio of B(Λ+c→Σ+K0S) relative to B(Λ+c→Σ+π+π−) is measured to be 0.0106±0.0031(stat.)±0.0004(syst.). After taking the world-average branching fractions of the reference decay channels, the branching fractions B(Λ+c→Σ0K+) and B(Λ+c→Σ+K0S) are determined to be (4.7±0.9(stat.)±0.1(syst.)±0.3(ref.))×10−4 and (4.8±1.4(stat.)±0.2(syst.)±0.3(ref.))×10−4, respectively. The branching fraction of the Λ+c→Σ+K0S decay is measured for the first time.
Measurement of e⁺e⁻ → π⁺π⁻D⁺D⁻ cross sections at center-of-mass energies from 4.190 to 4.946 GeV
(2022)
Using data samples collected with the BESIII detector operating at the BEPCII storage ring, we measure the cross sections of the e+e−→π+π−D+D− process at center-of-mass energies from 4.190 to 4.946 GeV with a partial reconstruction method. Two resonance structures are seen and the resonance parameters are determined from a fit to the cross section line shape. The first resonance we observe has a mass of (4373.1 ± 4.0 ± 2.2) MeV/c2 and a width of (146.5 ± 7.4 ± 1.3) MeV, in agreement with those of the Y(4390) state; the other resonance has a mass of (4706 ± 11 ± 4) MeV/c2, a width of (45 ± 28 ± 9) MeV, and a statistical significance of 4.1 standard deviations (σ). This is the first evidence for a vector state at this mass value. The spin-3 D-wave charmonium state X(3842) is searched for through the e+e−→π+π−X(3842)→π+π−D+D− process, and evidence with a significance of 4.2σ is found in the data samples with center-of-mass energies from 4.600 to 4.700 GeV.
Based on a sample of 448.1×106 ψ(3686) events collected with the BESIII detector, a study of ψ(3686)→ΛΛ¯π0 and ψ(3686)→ΛΛ¯η is performed. Evidence of the isospin-violating decay ψ(3686)→ΛΛ¯π0 is found for the first time with a statistical significance of 3.7σ, the branching fraction B(ψ(3686)→ΛΛ¯π0) is measured to be (1.42±0.39±0.59)×10−6, and its corresponding upper limit is determined to be 2.47×10−6 at 90\% confidence level. A partial wave analysis of ψ(3686)→ΛΛ¯η shows that the peak around Λη invariant mass threshold favors a Λ∗ resonance with mass and width in agreement with the Λ(1670). The branching fraction of the ψ(3686)→ΛΛ¯η is measured to be (2.34±0.18±0.52)×10−5. The first uncertainties are statistical and the second are systematic.
Measurement of e⁺e⁻ → π⁺π⁻D⁺D⁻ cross sections at center-of-mass energies from 4.190 to 4.946 GeV
(2022)
Using data samples collected with the BESIII detector operating at the BEPCII storage ring, we measure the cross sections of the e+e−→π+π−D+D− process at center-of-mass energies from 4.190 to 4.946 GeV with a partial reconstruction method. Two resonance structures are seen and the resonance parameters are determined from a fit to the cross section line shape. The first resonance we observe has a mass of (4373.1 ± 4.0 ± 2.2) MeV/c2 and a width of (146.5 ± 7.4 ± 1.3) MeV, in agreement with those of the Y(4390) state; the other resonance has a mass of (4706 ± 11 ± 4) MeV/c2, a width of (45 ± 28 ± 9) MeV, and a statistical significance of 4.1 standard deviations (σ). This is the first evidence for a vector state at this mass value. The spin-3 D-wave charmonium state X(3842) is searched for through the e+e−→π+π−X(3842)→π+π−D+D− process, and evidence with a significance of 4.2σ is found in the data samples with center-of-mass energies from 4.600 to 4.700 GeV.
We present the first search for the semileptonic decay D+s→π0e+νe using a data sample of electron-positron collisions recorded with the BESIII detector at center-of-mass energies between 4.178 and 4.226~GeV, corresponding to an integrated luminosity of 6.32~fb−1. This decay is expected to be sensitive to π0--η mixing. No significant signal is observed. We set an upper limit of 6.4×10−5 on the branching fraction at the 90% confidence level.
Measurement of the e⁺e⁻ → ωπ⁰π⁰ cross section at center-of-mass energies from 2.0 to 3.08 GeV
(2022)
The cross section of the process e+e−→ωπ0π0 is measured at nineteen center-of-mass energies from 2.0 to 3.08 GeV using data collected with the BESIII detector at the BEPCII storage ring. A resonant structure around 2.20 GeV is observed with statistical significance larger than 5σ. Using a coherent fit to the cross section line shape, the mass and width are determined to be M=2222±7±2 MeV/c2 and Γ=59±30±6 MeV, respectively, where the first uncertainties are statistical and the second ones are systematic.
Background. Intervertebral disc degeneration (IDD) at the cervicothoracic junction of spine is clinically relevant, however, little attention had been paid. T2 mapping and magnetic transfer ratio (MTR) are useful magnetic resonance imaging (MRI) techniques to quantitatively evaluate IDD, revealing the biochemical changes within the intervertebral disc. To compare T2 mapping with MTR imaging regarding their accuracy to quantitatively diagnose intervertebral disc degeneration at the cervicothoracic junction, influences of anatomical level, gender, age, and Pfrrmann grade of T2 relaxation time values and MTR values were evaluated.
Methods. Sixty-seven patients with neck and upper back pain were included and examined with both T2 mapping andMTR imaging. Te Pfrrmann grade, T2 relaxation time values, and MTR value of each disc between C7 and T3 were measured. Diferences were investigated among diferent segmental levels, genders, age ranges, and Pfrrmann grades. Te diagnostic accuracy of both MRI techniques was compared using the receiver operating characteristic (ROC) curves.
Results. No signifcant diference was detected comparing T2 relaxation time values or MTR values among diferent anatomical levels, genders, and segmental levels. And we generally found that T2 relaxation time values decreased, while MTR value increased with increasing age. Importantly, we demonstrated the signifcant correlation between either T2 relaxation time values or MTR value and Pfrrmann grade.
Conclusion. We proved the better accuracy of T2 mapping over MTR imaging to quantitatively evaluate the intervertebral disc degeneration of the cervicothoracic junction.
Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in the nucleotide‐binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs:
Formalin‐fixed, paraffin‐embedded (FFPE ), biobanked tissue samples offer an invaluable resource for clinical and biomarker research. Here, we developed a pressure cycling technology (PCT )‐SWATH mass spectrometry workflow to analyze FFPE tissue proteomes and applied it to the stratification of prostate cancer (PC a) and diffuse large B‐cell lymphoma (DLBCL ) samples. We show that the proteome patterns of FFPE PC a tissue samples and their analogous fresh‐frozen (FF ) counterparts have a high degree of similarity and we confirmed multiple proteins consistently regulated in PC a tissues in an independent sample cohort. We further demonstrate temporal stability of proteome patterns from FFPE samples that were stored between 1 and 15 years in a biobank and show a high degree of the proteome pattern similarity between two types of histological regions in small FFPE samples, that is, punched tissue biopsies and thin tissue sections of micrometer thickness, despite the existence of a certain degree of biological variations. Applying the method to two independent DLBCL cohorts, we identified myeloperoxidase, a peroxidase enzyme, as a novel prognostic marker. In summary, this study presents a robust proteomic method to analyze bulk and biopsy FFPE tissues and reports the first systematic comparison of proteome maps generated from FFPE and FF samples. Our data demonstrate the practicality and superiority of FFPE over FF samples for proteome in biomarker discovery. Promising biomarker candidates for PC a and DLBCL have been discovered.
Atmospheric aerosols and their effect on clouds are thought to be important for anthropogenic radiative forcing of the climate, yet remain poorly understood1. Globally, around half of cloud condensation nuclei originate from nucleation of atmospheric vapours2. It is thought that sulfuric acid is essential to initiate most particle formation in the atmosphere3,4, and that ions have a relatively minor role5. Some laboratory studies, however, have reported organic particle formation without the intentional addition of sulfuric acid, although contamination could not be excluded6,7. Here we present evidence for the formation of aerosol particles from highly oxidized biogenic vapours in the absence of sulfuric acid in a large chamber under atmospheric conditions. The highly oxygenated molecules (HOMs) are produced by ozonolysis of α-pinene. We find that ions from Galactic cosmic rays increase the nucleation rate by one to two orders of magnitude compared with neutral nucleation. Our experimental findings are supported by quantum chemical calculations of the cluster binding energies of representative HOMs. Ion-induced nucleation of pure organic particles constitutes a potentially widespread source of aerosol particles in terrestrial environments with low sulfuric acid pollution.