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The article compares the aesthetic notions of the "je ne sais quoi" (as it emerges in the Renaissance and is widely debated in the eighteenth century) and of the 'uncanny' as theorized by Ernst Jentsch and Sigmund Freud in the early twentieth century. Its hypothesis is that both notions, in situating aesthetic experience in a liminal space between pleasure and trouble, can be considered after-images of non-aesthetical notions - notions that belong to the domain of the sacred and have metamorphosed as forms of aesthetic undecidability through the paradigmatic fracture of early modernity. The article focuses on depictions of female figures directing their gaze upward - in the iconography of Sade's Justine, in popular imagery connected with Lourdes apparitions (1858), in medium photography, and in the images taken by Charcot of his hysterical patients at the Salpêtrière - and argues that they become a Warburgian Pathosformel indicating a space of undecidability and 'nonsense' between the subject and otherness.