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Der Kartograph und Mathematiker Carsten Niebuhr beteiligte sich Mitte des 18. Jahrhunderts an einer beschwerlichen Expedition in den arabischen und vorderasiatischen Raum. Seine Erkenntnisse und Erfahrungen verewigte er anschließend in seinem Buch »Die Arabische Reise«. Studierende eines Seminars der Vorderasiatischen Archäologie haben nun in einer Ausstellung, die ab Ende Oktober im Dithmarscher Dom gezeigt wird, Niebuhrs erstaunlich genaue und differenzierte Beobachtungen nachgezeichnet und mit dem heutigen Forschungsstand verglichen.
Auf Einladung des Forschungsinstituts Gesellschaftlicher Zusammenhalt (FGZ) diskutierten Prof. Dr. Nicole Deitelhoff (Politikwissenschaftlerin an der Goethe-Universität und Sprecherin des FGZ) und Prof. Dr. Michel Friedman (geschäftsführender Direktor des Center for Applied European Studies – CAES) mit zwei streiterfahrenen Gästen über das Thema »Grenzen der Meinungsfreiheit«: mit dem Staranwalt Christian Schertz und dem Kabarettisten Florian Schroeder. Die Diskussion im English Theatre Frankfurt wurde von Oberstufenschülerinnen und – schülern der Dreieichschule aus Langen analysiert, visualisiert und laufend mit Fragen ergänzt.
Neuer Band der Reihe Frankfurter Beiträge zur Erziehungswissenschaft nimmt Adornos berühmten Radioessay als Ausgangs- und Bezugspunkt für vielfältige Interpretationen und Gegenwartsanalysen.
Rezension zu: Sabine Andresen, Dieter Nittel, Christiane Thompson (Hg.) Erziehung nach Auschwitz bis heute. Aufklärungsanspruch und Gesellschaftsanalyse. Frankfurter Beiträge zur Erziehungswissenschaft, Band 22, Goethe-Universität, FB 04, 2019
Introduction: Stem cell transplantation is one of the most promising strategies to improve healing in chronic wounds as systemic administration of endothelial progenitor cells (EPC) enhances healing by promoting neovascularization and homing though a high amount of cells is needed. In the following study, we analysed whether local application can reduce the number of EPC needed achieving the same beneficial effect on wound healing.
Material and Methods: Wound healing after local or systemic treatment with EPC was monitored in vivo by creating standardized wounds on the dorsum of hairless mice measuring wound closure every second day. Systemic group received 2 × 106 EPC i.v. and locally treated group 2 × 105 EPC, locally injected. As control PBS injection was performed the same way. Expression of CD31, VEGF, CD90 and, SDF-1α was analysed immunohistochemically for evaluation of neovascularisation and amelioration of homing.
Results: Local (7.1 ± 0.45 SD) as well as systemic (6.1 ± 0.23 SD) EPC transplantation led to a significant acceleration of wound closure compared to controls (PBS local: 9.7 ± 0.5 SD, PBS systemic 10.9 ± 0.38 SD). Systemic application enhanced CD31 expression on day 6 after wounding and local EPC on 6 and 9 in comparison to control. VEGF expression was not significantly affected. Systemic and local EPC treatment resulted in a significantly enhanced SDF-1α and CD90 expression on all days investigated.
Conclusion: Local as well as systemic EPC treatment enhances wound healing. Moreover, beneficial effects are obtained with a tenfold decrease number of EPC when applied locally. Thus, local EPC treatment might be more convenient way to enhance wound healing as number of progenitor cells is limited.
TRIANNI mice carry an entire set of human immunoglobulin V region gene segments and are a powerful tool to rapidly isolate human monoclonal antibodies. After immunizing these mice with DNA encoding the spike protein of SARS-CoV-2 and boosting with spike protein, we identified 29 hybridoma antibodies that reacted with the SARS-CoV-2 spike protein. Nine antibodies neutralize SARS-CoV-2 infection at IC50 values in the subnanomolar range. ELISA-binding studies and DNA sequence analyses revealed one cluster of three clonally related neutralizing antibodies that target the receptor-binding domain and compete with the cellular receptor hACE2. A second cluster of six clonally related neutralizing antibodies bind to the N-terminal domain of the spike protein without competing with the binding of hACE2 or cluster 1 antibodies. SARS-CoV-2 mutants selected for resistance to an antibody from one cluster are still neutralized by an antibody from the other cluster. Antibodies from both clusters markedly reduced viral spread in mice transgenic for human ACE2 and protected the animals from SARS-CoV-2-induced weight loss. The two clusters of potent noncompeting SARS-CoV-2 neutralizing antibodies provide potential candidates for therapy and prophylaxis of COVID-19. The study further supports transgenic animals with a human immunoglobulin gene repertoire as a powerful platform in pandemic preparedness initiatives.