Refine
Year of publication
Document Type
- Article (408)
- Preprint (214)
- Contribution to a Periodical (8)
- Conference Proceeding (6)
- Working Paper (6)
- Book (1)
- Report (1)
Has Fulltext
- yes (644)
Is part of the Bibliography
- no (644)
Keywords
- e +-e − Experiments (12)
- BESIII (11)
- Branching fraction (8)
- Particle and Resonance Production (6)
- Charm Physics (5)
- Spectroscopy (5)
- Heavy-ion collisions (4)
- Lepton colliders (4)
- Quarkonium (4)
- portal hypertension (4)
- stochastic differential utility (4)
- COVID-19 (3)
- Charmed mesons (3)
- Diffraction (3)
- Elastic scattering (3)
- Electroweak interaction (3)
- Exotics (3)
- Hadronic decays (3)
- Polarization (3)
- e+-e− Experiments (3)
- Beam Energy Scan (2)
- Biomarkers (2)
- Branching fractions (2)
- Brassica napus (2)
- COVID-19 surveillance (2)
- Cancer (2)
- Charm physics (2)
- Charmonium (2)
- Chiral Magnetic Effect (2)
- Collectivity (2)
- Correlation (2)
- Electroweak Interaction (2)
- Epidemiology (2)
- FBSDE (2)
- Flavour Physics (2)
- Immunology (2)
- Leptonic, semileptonic & radiative decays (2)
- Mechanisms of disease (2)
- Mitochondria (2)
- Non-small cell lung cancer (2)
- Omicron (2)
- Particle decays (2)
- RHIC (2)
- Radiative decay (2)
- Radiotherapy (2)
- Rare diseases (2)
- Registries (2)
- SARS-CoV-2 (2)
- SARS-CoV-2 monitoring (2)
- STAR (2)
- Shear viscosity (2)
- Treatment (2)
- asset pricing (2)
- cirrhosis (2)
- consumption-portfolio choice (2)
- incomplete markets (2)
- microdosing (2)
- recursive utility (2)
- 140Ce (1)
- 3years (1)
- ACLF (1)
- ADGRE1 (1)
- AIS (1)
- ALK (1)
- ALK-rearranged NSCLC (1)
- ARDS (1)
- ATM (1)
- Acuris (1)
- Acute elbow dislocation (1)
- Advanced biliary tract cancer (1)
- Alpha-synuclein (1)
- Alternative oxidase (1)
- Antibiotic therapy (1)
- Antirheumatic agents (1)
- Araneae (1)
- Artificial Intelligence (1)
- Augenerkrankungen (1)
- Autosomal recessive cutis laxa type 1C (1)
- B-slope (1)
- B.1.1.529 (1)
- BA.4 (1)
- BA.5 (1)
- BESIII detector (1)
- BI1361849 (1)
- BTC (1)
- Bacterial leakage (1)
- Beam energy scan (1)
- Bhabha (1)
- Biodiversity Data (1)
- Biogeography (1)
- Biomedical engineering (1)
- Biomonitoring (1)
- Bipolar disorder (1)
- Born cross section (1)
- Born cross section measurement (1)
- Botanical Collections (1)
- Branching fraction measurement (1)
- CAD/CAM crown (1)
- CAKUT (1)
- CBA (1)
- CEP68 (1)
- COMP (1)
- COVID 19 (1)
- CP violation (1)
- CRVO (1)
- CV9202 (1)
- Cardiac implantable electronic devices (1)
- Cardiac rehabilitation (1)
- Cardiac resynchronization therapy (1)
- Cardiovascular disease risk (1)
- Cardiovascular diseases (1)
- Cement gap (1)
- Charged-particle multiplicity (1)
- Charm quark spatial diffusion coefficient (1)
- Charm vector (1)
- Charmonia (1)
- Charmonium (-like) (1)
- Chest pain unit (1)
- Child (1)
- Chiral magnetic effect (1)
- Circadian (1)
- Cirrhosis (1)
- Classification (1)
- Clinical trial (1)
- Coalescence (1)
- Cognitive impairment (1)
- Cohort studies (1)
- Cold nuclear matter effects (1)
- Colorectal cancer (1)
- Comparative effectiveness research (1)
- Complex II (1)
- Concept paper (1)
- Conometric connection (1)
- Consensus (1)
- Consensus document (1)
- Conservation (1)
- Consumption hump (1)
- Coronary intervention (1)
- Critical care (1)
- Critical point (1)
- Cross section (1)
- D meson (1)
- DME (1)
- DNA-PK (1)
- Dark photon (1)
- Dark sector (1)
- Data Standard (1)
- Data protection (1)
- Data sharing (1)
- Datenschutz (1)
- Dermatomyositis (1)
- Detection workflow (1)
- Deuteron production (1)
- Deutschland (1)
- Di-hadron correlations (1)
- Diagnosis (1)
- Digital (1)
- Digitization (1)
- ECM (1)
- EMR1 (1)
- Ecology (1)
- Ecophysiology (1)
- Ectoparasites (1)
- Education (1)
- Effective form factor (1)
- Einwanderer (1)
- Elastogenesis (1)
- Electromagnetic form factor (1)
- Electromagnetic form factors (1)
- Electromagnetic transitions (1)
- Elliptic flow (1)
- Equity (1)
- Etanercept (1)
- Exercise training (1)
- Experimental nuclear physics (1)
- Experimental particle physics (1)
- Extracellular matrix (1)
- Eye diseases (1)
- EyesiNet (1)
- F4/80 (1)
- FOS: Physical sciences (1)
- Fibulin-4 (1)
- Fibulin-5 (1)
- Flavor changing neutral currents (1)
- Flavor symmetries (1)
- Flow (1)
- Form factors (1)
- Forward physics (1)
- Fracture type (1)
- Fremdbild (1)
- GLM (1)
- Genetics (1)
- Genetics research (1)
- Geschichte 1981-1997 (1)
- Gomphus flavipes (1)
- Groomed jet radius (1)
- HCC (1)
- Hadron-Hadron scattering (experiments) (1)
- Hadronization (1)
- Hand-foot syndrome (1)
- Hantavirus (1)
- Health information (1)
- Health-seeking behaviour (1)
- Heart failure (1)
- Heavy Ion Experiments (1)
- Heavy Quark Production (1)
- Heavy ion collisions (1)
- Heavy-Ion Collision (1)
- Heavy-flavor decay electron (1)
- Heavy-ion (1)
- Helicity amplitude analysis (1)
- Helpline (1)
- Herbaria (1)
- Hif1α (1)
- High Energy Physics - Experiment (hep-ex) (1)
- Higher moments (1)
- Hyperons (1)
- Hypertension (1)
- Hypofractionated radiotherapy (1)
- ICU (1)
- IHMCIF (1)
- IL-6 (1)
- ILUVIEN (1)
- IR (1)
- ISS (1)
- Immunogenetics (1)
- Immunomonitoring (1)
- Implantable cardioverter-defibrillator (1)
- Inclusive branching fraction (1)
- Inflammation (1)
- Initial state radiation (1)
- Integrative Modeling (1)
- Interference fragmentation function (1)
- Invisible decays (1)
- J/ψ suppression (1)
- Jet substructure (1)
- K0S (1)
- K3EDTA plasma sampling (1)
- K48-linked (1)
- K63-linked (1)
- Konzeptpapier (1)
- Landscape ecology (1)
- Landschaftsökologie (1)
- Latent transforming growth factor β-binding protein 4 (1)
- Lehre (1)
- Libellen (1)
- Lifestyle (1)
- Lipidomics (1)
- Liver diseases (1)
- Ltbp-4 (1)
- Ltbp-4L (1)
- Ltbp-4S (1)
- L´evy framework (1)
- MACS (1)
- MCP-1 (1)
- MMPs (1)
- MRSA (1)
- MYCN amplification (1)
- Marginal integrity (1)
- Metabolomics (1)
- Microgap (1)
- Mitochondrial disease (1)
- Models & methods for nuclear reactions (1)
- Molecular diagnostic testing (1)
- Molecular medicine (1)
- Multiple parton interactions (1)
- Multivariate analysis (1)
- Myotis myotis (1)
- NAFLD (1)
- NET (1)
- NMDA IgA/IgM antibodies (1)
- NMDA antibody (1)
- NMR spectroscopy (1)
- NSCLC (1)
- NSTEMI (1)
- Net-charge correlations (1)
- Net-charge fluctuations (1)
- Netzhaut (1)
- Neutrinos (1)
- Neutron physics (1)
- Nonflow (1)
- Nuclear reactions (1)
- Nutzen (1)
- Oncogenes (1)
- Open Access (1)
- Ophiogomphus cecilia (1)
- Orphan disease (1)
- Osteoporosis (1)
- Outcome (1)
- Oxidative phosphorylation (1)
- PBSC (1)
- PDB-Dev (1)
- PDBx/mmCIF (1)
- PDE‐5‐inhibitor (1)
- PDGFRβ (1)
- PI3K (1)
- PRRT (1)
- PTEN (1)
- Pacemaker (1)
- Parkinson disease (1)
- Parkinson’s disease (1)
- Particle and resonance production (1)
- Particle phenomena (1)
- Patient safety (1)
- Periodontal disease (1)
- Periodontal therapy (1)
- Pest-crop interactions (1)
- Phalangeal fractures (1)
- Physical activity (1)
- Plasminogen (1)
- Platelets (1)
- Pneumonia (1)
- Portal veins (1)
- Poverty (1)
- Pre-analytics (1)
- Preclinical research (1)
- Predictive markers (1)
- Prevention (1)
- Prognosis (1)
- Prognostic models (1)
- Prostaglandin (1)
- Proton (1)
- Proton-proton collisions (1)
- Proton–proton collisions (1)
- Psychiatric disorders (1)
- Psychiatry (1)
- Puumala virus (1)
- QCD (1)
- Quantum chromodynamics (1)
- RAS pathway (1)
- RNA (1)
- RNA-binding proteins (1)
- Radiative capture (1)
- Rapps (1)
- Rare decays (1)
- Real world (1)
- Register (1)
- Remission (1)
- Research Infrastructure (1)
- Resonance reactions (1)
- Respiratory chain (1)
- Retina (1)
- Retro-IDEAL (1)
- Rh(II) catalysis (1)
- Rheumatoid arthritis (1)
- Rodent-associated infections (1)
- Roosting place (1)
- SARS CoV 2 (1)
- SD-OCT (1)
- SLC20A1 (1)
- SPSS (1)
- STED superresolution (1)
- Sampling protocol (1)
- Schulbuch (1)
- Schädling (1)
- Seasonal variation (1)
- Seltene Erkrankungen (1)
- Semantics (1)
- Semi-leptonic decays (1)
- Single-molecule biophysics (1)
- Social determinants (1)
- SoftDrop (1)
- Solar insolation (1)
- Sorafenib (1)
- Spatial scales (1)
- Spatio-temporal patterns (1)
- Spin alignment (1)
- Spine care (1)
- Spinturnix myoti (1)
- Splitting function (1)
- Standardization (1)
- Staphylococcus aureus (1)
- Stentoplasty (1)
- Steroid (1)
- Student (1)
- Suicide (1)
- Sunlight (1)
- Super-resolution microscopy (1)
- Surgical oncology (1)
- TACE (1)
- TGR(mREN2)27 (1)
- TP53 mutation status (1)
- Taxonomy (1)
- Techniques Electromagnetic calorimeters (1)
- Telemedicine (1)
- Thermal model (1)
- Thoracic trauma (1)
- Threshold effect (1)
- Thrombosis (1)
- Thromboxane (1)
- Transversity (1)
- UWB diagnostics (1)
- VEGF (1)
- VEGFR-2 (1)
- VEGFR-3 (1)
- Variant of concern (1)
- Veins (1)
- Vertebral augmentation (1)
- Vertebral body stenting (1)
- Vertebral fracture (1)
- Vitreous samples (1)
- Wastewater-based epidemiology (WBE) (1)
- Western diet (1)
- Worldwide Protein Data Bank (1)
- X-ray crystallography (1)
- Y states (1)
- accessory proteins (1)
- acute decompensation (1)
- acute myeloid leukemia (1)
- acute-on-chronic liver failure (1)
- adaptive cardiac remodelling (1)
- adverse events (1)
- alternative oxidase (1)
- anaesthesia in orthopaedics (1)
- anaesthetics (1)
- autoantibodies (1)
- azaindole (1)
- backward stochastic differential equation (1)
- bioactivity testing (1)
- bladder exstrophy-epispadias complex (1)
- bleomycin (1)
- bundle (1)
- c-kit (1)
- capture (1)
- cardiac ischaemia‐reperfusion (1)
- cartilage (1)
- cell stress (1)
- cell-free protein synthesis (1)
- center-of-mass energy (1)
- centrosome (1)
- centrosome linker (1)
- cerium (1)
- certainty equivalents (1)
- charmonium-like states (1)
- cloacal malformation (1)
- complications (1)
- computed tomography (1)
- consumption hump (1)
- convergence (1)
- cross-section (1)
- cytarabine dose (1)
- diabetic macular edema (1)
- diazo compounds (1)
- dimuon (1)
- dynamic programming (1)
- e+e − annihilation (1)
- e+e⁻ − Experiments (1)
- e+e− Experiments (1)
- easyPACId (1)
- ectosomes (1)
- education (1)
- elderly (1)
- electron transport chain (1)
- electron-positron collision (1)
- epigeic spiders (1)
- epigäische Spinnen (1)
- erectile dysfunction (1)
- exosomes (1)
- extracellular vesicles (1)
- fibrogenesis (1)
- fixed point approach (1)
- fluocinolone acetonide (1)
- fluorescent dye (1)
- functional genetics (1)
- generalist predators (1)
- generalistische Prädatoren (1)
- geriatric medicine (1)
- global change (1)
- guidelines (1)
- habit formation (1)
- habitat destruction (1)
- hadron spectroscopy (1)
- hadronic events (1)
- health information exchange (1)
- heavy-ion collisions (1)
- helicity amplitude analysis (1)
- hematotoxicity (1)
- hepatic encephalopathy (1)
- hepatic stellate cells (1)
- hepatocellular cancer (1)
- high-risk neuroblastoma (1)
- immunity (1)
- impatience (1)
- in vitro models (1)
- inclusive J/ψ decays (1)
- inflammation (1)
- intrinsically disordered region (1)
- jumps (1)
- kidney formation (1)
- land use (1)
- leisure (1)
- life-cycle utility maximization (1)
- liver (1)
- liver fibrosis (1)
- mRNA active cancer immunotherapy (1)
- macrophage (1)
- metallo β lactamases (1)
- microparticles (1)
- microvesicles (1)
- microwave ablation (1)
- microwave breast imaging (1)
- minimal information requirements (1)
- mouse (1)
- mouse model (1)
- multiresistant bacteria (1)
- n_TOF (1)
- natural products (1)
- nematophin (1)
- neuroendocrine tumor (1)
- neutralizing antibodies (1)
- neutron (1)
- nonstructural proteins (1)
- non‐selective beta‐blocker (1)
- normalization (1)
- nucleosynthesis (1)
- number of J/ψ events (1)
- optimal investment (1)
- osteoarthritis (1)
- oval split ring resonator (1)
- p+p collisions (1)
- p53 pathway (1)
- patient study (1)
- peptide receptor radionuclide therapy (1)
- peripheral blood stem cell collection (1)
- polyubiquitin (1)
- portosystemic shunt (1)
- prevention (1)
- primary biliary cholangitis (1)
- proteobacteria (1)
- qualitative research (1)
- quality control (1)
- rare diseases (1)
- reactive oxygen species (1)
- renin-angiotensin system (1)
- reproducibility (1)
- resectability (1)
- rigor (1)
- rootletin (1)
- s-process (1)
- second line therapy (1)
- sequential ALK-inhibitor therapy (1)
- simplified production (1)
- sorafenib (1)
- sphingolipid sphingosine-1-phosphate (1)
- sphingolipids (1)
- sphingosine-1-phosphate receptor 5 (1)
- spike protein (1)
- spontaneous portosystemic shunt (1)
- standardization (1)
- steatosis (1)
- stochastic volatility (1)
- structural proteins (1)
- surgery (1)
- systemic sclerosis (1)
- tetraquark (1)
- theranostics (1)
- thiol inhibitors (1)
- thrombospondins (1)
- treatment (1)
- treatment response (1)
- trigger efficiency (1)
- ubiquitin-conjugating enzymes (1)
- urinary tract development (1)
- ursodeoxycholic acid (1)
- variant of concern (1)
- variants of concern (1)
- wage hump (1)
- wastewater-based epidemiology (WBE) (1)
- welfare loss (1)
- wwPDB (1)
- zebrafish development (1)
- Λ+c baryon (1)
- Σ hyperon (1)
- Υ suppression (1)
- ψ(3686) (1)
- fibrogenesis (1)
Institute
- Physik (374)
- Frankfurt Institute for Advanced Studies (FIAS) (106)
- Medizin (91)
- Geowissenschaften (23)
- Präsidium (8)
- Biochemie und Chemie (7)
- Biochemie, Chemie und Pharmazie (7)
- Biowissenschaften (7)
- Wirtschaftswissenschaften (7)
- Center for Financial Studies (CFS) (6)
Fragestellung Vergleichende Untersuchung zweier Arthrosemodelle: komplette mediale Meniskektomie und vordere Kreuzbanddurchtrennung des Kaninchens zu frühen Zeitpunkten. Methoden 4 verschiedene Gruppen von männlichen erwachsenen NZW Kaninchen wurden untersucht: einseitige komplette mediale Meniskektomie (ME;n=32), einseitige vordere Kreuzbanddurchtrennung (ACLT;n=32),als Kontrollgruppen die einseitige Gelenkeröffnung (sham-OP;n=32) und unoperierte Kontrollen (n=40).Standardisiert erfolgte die mediale Arthrotomie.Die Kaninchen wurden in der vom Regierungspräsidium genehmigten Studie nach 2, 4, 8 und 12 Wochen getötet. Der makroskopische Befund des rechten und linken Kniegelenks wurde mittels eines 9 - Felderschemas (International Cartilage Repair Society, 1998) für Femur, Tibia und Patella beurteilt. Weitere Parameter wie Gelenkerguss (Punktion),Osteophytenbildung, Meniskusregenerat bzw. –verletzungen wurden im Zeitverlauf dokumentiert.Die Befunde wurden mit Wilcoxon und Mann-Whitney-U-Test bewertet. 4 μm Schnitte der rechten und linken Tibien wurden mit H&E und Safranin O gefärbt,das histologische Grading erfolgte mit einem modifizierten Mankin Score, die statistische Beurteilung mit Wilcoxon und Mann-Whitney-U-Test. Immunhistochemisch wurden Proteoglykan- und Kollagentypen sowie kleine Knorpelstrukturproteine im Knorpel und Osteophyten untersucht. Ergebnisse Die 136 Tiere hatten einen unauffälligen postoperativen Verlauf. Makroskopisch zeigten die medialen Tibien und medialen Femuren bereits 2 Wochen nach ME eine statistisch signifikante Arthrose (intraindividuelle kontralaterale Kontrolle und im Vergleich zu den nichtoperierten Kontrollen).2 Wochen nach ACLT war nur der mediale Femur signifikant verändert. Die Läsionsgrösse und die Anzahl betroffener Areale nahmen mit der Zeit zu. 12 Wochen nach ACLT bestanden medial wie lateral auf Tibia und Femur statistisch signifikante Läsionen, nach ME waren die Läsionen im medialen Kompartment. Beispielhaft für weitere Ergebnisse:ein signifikantes Meniskusregenerat wurde in 15 / 32 Fällen ohne zeitabhängige Grössenzunahme zu den „späten“ Zeitpunkten nachgewiesen. Mikroskopisch waren die arthrotischen Veränderungen ebenfalls bereits nach 2 Wochen nachweisbar,ein signifikantes Fortschreiten der Arthrose wurde mikroskopisch nicht nachgewiesen.Die Läsionen waren(geplantermassen) oft frühe Läsionen. Schlussfolgerungen Bisher war nicht dokumentiert,dass frühzeitig nach bereits 2 Wochen eine makroskopisch deutliche Gelenkknorpelveränderung im Kaninchenmodell sowohl der kompletten medialen ME als auch der ACLT einsetzt. Die Untersuchung erlaubte ein genaues Mapping der arthrotischen Areale im zeitlichen Verlauf.Viele Aspekte des postoperativen Verlaufs (z.B. Gelenkerguss, Meniskusregenerat, zusätzliche Meniskusrisse) konnten detailliert dokumentiert werden. Die immunhistochemischen Untersuchungen geben Hinweise für den gezielten Einsatz von Knorpelmarkern.Die erhobenen Parameter erlauben den differenzierten Einsatz beider Modelle.
Fragestellung Spontanheilungen von Rupturen des vorderen Kreuzbandes (VKB) wurden wiederholt mittels MRT beschrieben. In grundlegenden tierexperimentellen Untersuchungen wird geschlussfolgert, dass es keine Regeneration gäbe. Die Morphologie der Spontanheilung des VKB wurde im Tiermodell des Kaninchens untersucht. Methoden 32 männliche Kaninchen wurden medial arthrotomiert und das VKB durchtrennt. Die Durchtrennung erfolgte unter Sicht mittels Nr. 15 Skalpell, zusätzlich wurde die vollständige Trennung der Stümpfe durch mehrfache Instrumentenpassage kontrolliert. Eine Resektion von Fasern erfolgte nicht. Je 8 Tiere wurden 2, 4, 8 und 12 Wochen nach dem Eingriff getötet. Die Morphologie der Heilungsverläufe wurde nach Lo et al. [1] klassifiziert, neue Typen der Klassifikation hinzugefügt. Typ B (intrasynoviale Ruptur) und Typ C (knöcherner Ausriss) waren studienbedingt nicht möglich. Die Studie war vom Regierungspräsidium genehmigt. Ergebnisse Die untersuchten Tiere hatten einen unauffälligen postoperativen Verlauf. Bei unterschiedlicher Ausprägung hatten alle Tiere makroskopisch eine Knorpelschädigung. Nach chirurgischer Durchtrennung waren die VKBenden durchschnitten (mop ended Typ A). Dieser Typ wurde bei der Dissektion nicht mehr vorgefunden. Die VKBstümpfe waren bei Dissektion: retrahiert (Typ D), mit dem hinteren Kreuzband verwachsen (E), resorbiert (F), miteinander verbunden = narbengeheilt (G), oder es lag eine Kombination (H) verschiedener Typen vor. Als neue Typen wurden Verwachsungen mit dem Meniskus (I) oder mit der Gelenkkapsel bzw. dem Fettkörper (K) beschrieben. Die VKBstümpfe waren gering (G 1 = 7), deutlich (G2 = 3 bzw. 4 insges. bei zusätzlicher Verwachsung mit dem Innenmeniskus) oder hypertroph (G 3 = 3) miteinander verwachsen. [Tab. 1] Schlussfolgerungen Der VKBriss führt häufig zur Kniegelenksinstabilität und Osteoarthrose. Nach Durchtrennung des VKB wird in Studien der Osteoarthroseforschung im Kaninchenmodell der Befund nie detailliert. In einem systematischen Vergleich der Regenerationsfähigkeit von partiell und komplett durchtrennten VKBs fanden Hefti et al. [2] weder bei skeletall unreifen noch bei jungen erwachsenen Kaninchen eine Regeneration nach kompletter Durchtrennung. Sie berichteten als Regelfall die Resorption nach 3 Monaten, in 2 Fällen Verwachsungen mit dem hinteren Kreuzband. Die hier berichteten Daten sind im Gegensatz zu Hefti's Untersuchungen. Sie stimmen aber gut mit humanen MRT-Untersuchungen und Arthroskopien nach Kreuzbandverletzungen überein. Das VKB versucht durch Verwachsung eine Heilung der VKBstümpfe zu erzielen oder Anschluss an andere Kniegelenksstrukturen zu gewinnen. Somit besteht auch im Tiermodell des Kaninchens eine gewisse Spontanheilungsaktivität des VKB, deren biomechanische Stabilität allerdings oft unzureichend erschien. Eine Kniegelenksarthrose entwickelte sich in den untersuchten Gelenken.
Background: To identify variables predicting outcome in neuroblastoma patients assigned to the high-risk group solely by the presence of MYCN oncogene amplification (MNA). Methods: Clinical characteristics, genomic information, and outcome of 190 patients solely assigned to high-risk neuroblastoma by MNA were analyzed and compared to 205 patients with stage 4 neuroblastoma aged ≥18 months with MNA (control group). Results: Event-free survival (EFS) and overall survival (OS) at 10 years were 47% (95%-CI 39–54%) and 56% (95%-CI 49–63%), respectively, which was significantly better than EFS and OS of the control group (EFS 25%, 95%-CI 18–31%, p < 0.001; OS 32% 95%-CI 25–39%, p < 0.001). The presence of RAS-/p53-pathway gene alterations was associated with impaired 10-year EFS and OS (19% vs. 55%, and 19% vs. 67%, respectively; both p < 0.001). In time-dependent multivariable analyses, alterations of RAS-/p53-pathway genes and the extent of the best primary tumor resection were the only independent prognostic variables for OS (p < 0.001 and p = 0.011, respectively). Conclusions: Neuroblastoma patients attributed to high risk solely by MYCN amplification have generally a more favorable outcome. Mutations of genes of the RAS and/or p53 pathways and incomplete resection are the main risk factors predicting poor outcome.
Introduction: The Retro-IDEAL (ILUVIEN Implant for chronic DiabEtic MAcuLar edema) study is a retrospective study designed to assess real-world outcomes achieved with the ILUVIEN® (0.19 mg fluocinolone acetonide (FAc)) in patients with chronic diabetic macular edema (DME) in clinical practices in Germany.
Methods: This study was conducted across 16 sites in Germany and involved 81 eyes (63 patients) with persistent or recurrent DME and a prior suboptimal response to a first-line intravitreal therapy (primarily anti-VEGF intravitreal therapies).
Results: Patients were followed-up for 30.8 ± 11.3 months (mean ± standard deviation) and had a mean age of 68.0 ± 10.4 years. Best-recorded visual acuity (BRVA) improved by +5.5 letters at month 9 (P ⩽ 0.005, n=56; from a baseline of 49 letters) and this was maintained through to month 30 (P ⩽ 0.05, n = 42). There was a concurrent improvement in central macular thickness with a reduction from 502 µm at baseline to 338 µm at year 1 (P ⩽ 0.0001, n = 43). This effect was sustained to year 3 (i.e. 318 µm; P ⩽ 0.0001, n = 29). Mean intraocular pressure (IOP) remained constant between baseline and year 3 with a peak change of 1.9 mm Hg occurring at year 1. Elevated IOP was observed in a similar percentage of patients prior to (22.2% of cases) and following (27.2%) treatment with the FAc implant. In the majority of cases, these elevations were managed effectively with IOP medications.
Conclusions: Despite substantial amounts of prior intravitreal treatments – primarily with anti–vascular endothelial growth factor (VEGF) drugs – this real-world study showed that sustained structural and functional improvements can last for up to 3 years with a single FAc implant.
Bei der Vielzahl der Amphibiengewässer müssen für den Amphibienschutz eindeutige Präferenzen gesetzt werden. Vorrangig sind die artenreichen Gewässer und die Gewässer mit Rote-Liste-Arten zu sichern und gegebenenfalls zu optimieren (vgl. Tab. 5). Liegen die Laichgewässer isoliert, sind im Bereich geeigneter Ausbreitungsachsen Amphibiengewässer neu anzulegen, sodass mittelfristig wieder ein genetischer Austausch zwischen den isolierten Populationen möglich wird. Für den Laubfrosch wurde ein entsprechendes Artenhilfsprogramm in den letzten Jahren erarbeitet (BEINLICH & WYCISK 2000). Die dort herausgearbeiteten Ausbreitungskorridore kommen auch den meisten anderen Arten zugute und können somit übernommen werden. Lediglich für Geburtshelferkröte und Kreuzkröte müssen aufgrund abweichender Lebensraumansprüche eigene Ausbreitungsachsen definiert werden. Sie sind in schraffiert dargestellt. Aber auch Gewässer mit großen Amphibienpopulationen häufiger Arten gilt es zu sichern und zu optimieren, denn diese Vorkommen stellen aufgrund des Populationsüberschusses ein wichtiges Reservoir für die Neubesiedlung verwaister Lebensräume dar. Wo Straßen Ausbreitungsachsen queren, sind weiterhin geeignete Vorrichtungen für den Amphibienschutz zu errichten (vgl. WYCISK et al. 2000). Weiterhin sind grundsätzlich alle zurzeit ungenutzten Teiche und sonstige Kleingewässer als aktuelle oder auch potentielle Amphibienlaichgewässer zu erhalten, ggf. nachdem zuvor Optimierungsmaßnahmen durchgeführt wurden. So sind viele gefährdete Arten auf besonnte Gewässer angewiesen; schattenwerfende Gehölze sind deshalb regelmäßig zurückschneiden. Flachufer und Ufervegetation sowie Fischfreiheit sind ebenfalls von großer Bedeutung für viele Amphibienarten. Aufgrund der großen Bedeutung der Abgrabungsgewässer insbesondere für gefährdete Amphibienarten ist weiterhin bei allen zukünftigen und soweit möglich auch bei aktuellen Abgrabungen darauf zu achten, dass amphibiengerechte Klein- und Kleinstgewässer geschaffen und erhalten werden. Dies gilt insbesondere für Abgrabungen im Bereich der in dargestellten Ausbreitungskorridore für Geburtshelferkröte und Kreuzkröte. Im Bereich des Muschelkalks sollten notfalls auch Kleingewässer durch Einbau von wasserundurchlässigem Material (Ton) geschaffen werden. Die Maßnahmen können zum überwiegenden Teil im Rahmen von notwendigem Ausgleich oder Ersatz für Eingriffe in Natur und Landschaft durchgeführt werden. Weiterhin sollten die Gewässer in Naturschutzgebieten durch die zuständigen Stellen in einen für den Naturschutz optimalen Zustand gebracht werden. Der aktuelle Zustand lässt oftmals zu wünschen übrig (vgl. Tab. 5). Aber nicht nur die öffentliche Hand ist gefragt. Auch jeder Gartenbesitzer kann durch die Anlage eines Gartenteiches ohne Fischbesatz und durch naturnahe Gestaltung des Gartens einen Beitrag zur Förderung der heimischen Amphibien leisten. Amphibien werden sich in der Regel bereits nach wenigen Jahren von allein einstellen. Von gut gemeinten Besatzmaßnahmen ist aber abzuraten; denn alle heimischen Amphibienarten unterliegen dem Artenschutz und dürfen aus der Natur nicht entnommen werden!
This paper relates recursive utility in continuous time to its discrete-time origins and provides a rigorous and intuitive alternative to a heuristic approach presented in [Duffie, Epstein 1992], who formally define recursive utility in continuous time via backward stochastic differential equations (stochastic differential utility). Furthermore, we show that the notion of Gâteaux differentiability of certainty equivalents used in their paper has to be replaced by a different concept. Our approach allows us to address the important issue of normalization of aggregators in non-Brownian settings. We show that normalization is always feasible if the certainty equivalent of the aggregator is of expected utility type. Conversely, we prove that in general L´evy frameworks this is essentially also necessary, i.e. aggregators that are not of expected utility type cannot be normalized in general. Besides, for these settings we clarify the relationship of our approach to stochastic differential utility and, finally, establish dynamic programming results. JEL Classifications: D81, D91, C61
We consider the continuous-time portfolio optimization problem of an investor with constant relative risk aversion who maximizes expected utility of terminal wealth. The risky asset follows a jump-diffusion model with a diffusion state variable. We propose an approximation method that replaces the jumps by a diffusion and solve the resulting problem analytically. Furthermore, we provide explicit bounds on the true optimal strategy and the relative wealth equivalent loss that do not rely on quantities known only in the true model. We apply our method to a calibrated affine model. Our findings are threefold: Jumps matter more, i.e. our approximation is less accurate, if (i) the expected jump size or (ii) the jump intensity is large. Fixing the average impact of jumps, we find that (iii) rare, but severe jumps matter more than frequent, but small jumps.
Enhanced labeling density and whole-cell 3D dSTORM imaging by repetitive labeling of target proteins
(2018)
With continuing advances in the resolving power of super-resolution microscopy, the inefficient labeling of proteins with suitable fluorophores becomes a limiting factor. For example, the low labeling density achieved with antibodies or small molecule tags limits attempts to reveal local protein nano-architecture of cellular compartments. On the other hand, high laser intensities cause photobleaching within and nearby an imaged region, thereby further reducing labeling density and impairing multi-plane whole-cell 3D super-resolution imaging. Here, we show that both labeling density and photobleaching can be addressed by repetitive application of trisNTA-fluorophore conjugates reversibly binding to a histidine-tagged protein by a novel approach called single-epitope repetitive imaging (SERI). For single-plane super-resolution microscopy, we demonstrate that, after multiple rounds of labeling and imaging, the signal density is increased. Using the same approach of repetitive imaging, washing and re-labeling, we demonstrate whole-cell 3D super-resolution imaging compensated for photobleaching above or below the imaging plane. This proof-of-principle study demonstrates that repetitive labeling of histidine-tagged proteins provides a versatile solution to break the "labeling barrier" and to bypass photobleaching in multi-plane, whole-cell 3D experiments.
Suitable and reproducible experimental models of translational research in reconstructive surgery that allow in-vivo investigation of diverse molecular and cellular mechanisms are still limited. To this end we created a novel murine model of acute hindlimb ischemia-reperfusion to mimic a microsurgical free flap procedure. Thirty-six C57BL6 mice (n = 6/group) were assigned to one control and five experimental groups (subject to 6, 12, 96, 120 hours and 14 days of reperfusion, respectively) following 4 hours of complete hindlimb ischemia. Ischemia and reperfusion were monitored using Laser-Doppler Flowmetry. Hindlimb tissue components (skin and muscle) were investigated using histopathology, quantitative immunohistochemistry and immunofluorescence. Despite massive initial tissue damage induced by ischemia-reperfusion injury, the structure of the skin component was restored after 96 hours. During the same time, muscle cells were replaced by young myotubes. In addition, initial neuromuscular dysfunction, edema and swelling resolved by day 4. After two weeks, no functional or neuromuscular deficits were detectable. Furthermore, upregulation of VEGF and tissue infiltration with CD34-positive stem cells led to new capillary formation, which peaked with significantly higher values after two weeks. These data indicate that our model is suitable to investigate cellular and molecular tissue alterations from ischemia-reperfusion such as occur during free flap procedures.
Gemas Artikel 11 der FFH-Richtlinie ist ein Monitoring des Erhaltungszustandes der Arten von gemeinschaftlicher Bedeutung durchzufuhren. Weiterhin ist nach Artikel 12 eine fortlaufende Überwachung des unbeabsichtigten Fangs oder Tötens der Anhang IV-Tierarten vorgeschrieben, worauf gegebenenfalls weiterführende Erhaltungsmaßnahmen und Forschung aufbauen sollen. Im § 40 BNatSchG wird dieses Monitoring in die Verantwortung der Bundesländer übergeben.
The Tarim River basin, located in Xinjiang, NW China, is the largest endorheic river basin in China and one of the largest in all of Central Asia. Due to the extremely arid climate, with an annual precipitation of less than 100 mm, the water supply along the Aksu and Tarim rivers solely depends on river water. This is linked to anthropogenic activities (e.g., agriculture) and natural and semi-natural ecosystems as both compete for water. The ongoing increase in water consumption by agriculture and other human activities in this region has been enhancing the competition for water between human needs and nature. Against this background, 11 German and 6 Chinese universities and research institutes have formed the consortium SuMaRiO (Sustainable Management of River Oases along the Tarim River; http://www.sumario.de), which aims to create a holistic picture of the availability of water resources in the Tarim River basin and the impacts on anthropogenic activities and natural ecosystems caused by the water distribution within the Tarim River basin. On the basis of the results from field studies and modeling approaches as well as from suggestions by the relevant regional stakeholders, a decision support tool (DST) will be implemented that will then assist stakeholders in balancing the competition for water, acknowledging the major external effects of water allocation to agriculture and to natural ecosystems. This consortium was formed in 2011 and is funded by the German Federal Ministry of Education and Research. As the data collection phase was finished this year, the paper presented here brings together the results from the fields from the disciplines of climate modeling, cryology, hydrology, agricultural sciences, ecology, geoinformatics, and social sciences in order to present a comprehensive picture of the effects of different water availability schemes on anthropogenic activities and natural ecosystems along the Tarim River. The second objective is to present the project structure of the whole consortium, the current status of work (i.e., major new results and findings), explain the foundation of the decision support tool as a key product of this project, and conclude with application recommendations for the region. The discharge of the Aksu River, which is the major tributary of the Tarim, has been increasing over the past 6 decades. From 1989 to 2011, agricultural area more than doubled: cotton became the major crop and there was a shift from small-scale to large-scale intensive farming. The ongoing increase in irrigated agricultural land leads to the increased threat of salinization and soil degradation caused by increased evapotranspiration. Aside from agricultural land, the major natural and semi-natural ecosystems are riparian (Tugai) forests, shrub vegetation, reed beds, and other grassland, as well as urban and peri-urban vegetation. Within the SuMaRiO cluster, focus has been set on the Tugai forests, with Populus euphratica as the dominant tree species, because these forests belong to the most productive and species-rich natural ecosystems of the Tarim River basin. At sites close to the groundwater, the annual stem diameter increments of Populus euphratica correlated with the river runoffs of the previous year. However, the natural river dynamics cease along the downstream course and thus hamper the recruitment of Populus euphratica. A study on the willingness to pay for the conservation of the natural ecosystems was conducted to estimate the concern of the people in the region and in China's capital. These household surveys revealed that there is a considerable willingness to pay for conservation of the natural ecosystems, with mitigation of dust and sandstorms considered the most important ecosystem service. Stakeholder dialogues contributed to creating a scientific basis for a sustainable management in the future.
Microwave sensors in medical environments play a significant role due to the contact-less and non-invasive sensing mechanism to determine dielectric properties of tissue. In this work, a theranostic sensor based on Split Ring Resonators (SRRs) is presented that provides two operation modes to detect and treat tumor cells, exemplary in the liver. For the detection mode, resonance frequency changes due to abnormalities are evaluated, and in the treatment mode, microwave ablation is performed. The planar sensor structure can be integrated into a needle like a surgery tool that evokes challenges concerning size limitations and biocompatibility. To meet the size requirements and provide a reasonable operating frequency, properties of oval shaped SRRs are investigated. By elongating the radius of the SRR in one direction, the resonance frequency can be decreased significantly compared to circular SRR by a factor of two below 12 GHz. In order to validate the detection and treatment characteristics of the sensor, full wave simulations and measurements are examined. Clear resonance shifts are detected for loading the sensor structures with phantoms mimicking healthy and malignant tissue. For treatment mode evaluation, ex vivo beef liver tissue was ablated leading to a lesion zone 1.2 cm × 1 cm × 0.3 cm with a three minute exposure of maximum 2.1 W
Der UniReport sprach im Institut für Soziologie mit Prof. Thomas Lemke, dem Geschäftsführenden Direktor des Instituts, und den Studierenden Luisa Hecker (Master) und Adam Jendrzejewski (Bachelor) über das Selbstverständnis des Faches, über Studienbedingungen und über die gesellschaftliche Rolle der Soziologie.
Die Studie »Scale-ups in Europe: an untapped potential« ist in Zusammenarbeit der GoetheUniversität mit der Innovationsplattform TechQuartier und der Yi Shi Foundation entstanden. Dr. Thomas Funke, Co-Direktor des TechQuartiers, und Research Manager Dominik Zborek haben die Studie federführend erstellt.
Der Nationale Aktionsplan für Menschen mit Seltenen Erkrankungen (SE) enthält 52 konkrete Maßnahmen, u. a. in den Handlungsfeldern Versorgung, Forschung, Diagnose und Informationsmanagement. Mit dem Ziel, langfristig die Qualität und Interoperabilität von nationalen Registern zu erhöhen, sieht Maßnahmenvorschlag 28 die Etablierung einer Strategiegruppe „Register für Seltene Erkrankungen“ vor. Diese Strategiegruppe hat 2016 ihre Arbeit aufgenommen. Sie berichtet hier über Entwicklungen auf nationaler und internationaler Ebene, um Empfehlungen für nationale Initiativen daraus abzuleiten.
Zusätzlich werden die Konsentierung und Implementierung sowie mit der Zeit ggf. die Anpassung eines Minimaldatensatzes zur Verwendung in Registern für Seltene Erkrankungen erläutert. Zusätzlich werden die verwendeten Datenelemente bzw. -schemata in einem sog. Metadata Repository abgebildet. Dieses Positionspapier wurde durch die Strategiegruppe sowie weitere Autoren erarbeitet und innerhalb der Gruppe konsentiert. Es wird als Konzeptpapier zum Aufbau und Betrieb von Registern der Strategiegruppe „Register“ veröffentlicht.
Background: While the incidence and aspects of pneumonia in ICU patients has been extensively discussed in the literature, studies on the occurrence of pneumonia in severely injured patients are rare. The aim of the present study is to elucidate factors associated with the occurrence of pneumonia in severely injured patients with thoracic trauma.
Setting: Level-I University Trauma Centres associated with the TraumaRegister DGU®.
Methods: A total of 1162 severely injured adult patients with thoracic trauma documented in the TraumaRegister DGU® (TR-DGU) were included in this study. Demographic data, injury severity, duration of mechanical ventilation (MV), duration of ICU stay, occurrence of pneumonia, bronchoalveolar lavage, aspiration, pathogen details, and incidences of mortality were evaluated. Statistical evaluation was performed using SPSS (Version 25.0, SPSS, Inc.) software.
Results: The overall incidence of pneumonia was 27.5%. Compared to patients without pneumonia, patients with pneumonia had sustained more severe injuries (mean ISS: 32.6 vs. 25.4), were older (mean age: 51.3 vs. 47.5) and spent longer periods under MV (mean: 368.9 h vs. 114.9 h). Age, sex (male), aspiration, and duration of MV were all independent predictors for pneumonia occurrence in a multivariate analysis. The cut-off point for duration of MV that best discriminated between patients who would and would not develop pneumonia during their hospital stay was 102 h. The extent of thoracic trauma (AISthorax), ISS, and presence of pulmonary comorbidities did not show significant associations to pneumonia incidence in our multivariate analysis. No significant difference in mortality between patients with and without pneumonia was observed.
Conclusions: Likelihood of pneumonia increases with age, aspiration, and duration of MV. These parameters were not found to be associated with differences in outcomes between patients with and without pneumonia. Future studies should focus on independent parameters to more clearly identify severely injured subgroups with a high risk of developing pneumonia.
Level of evidence: Level II - Retrospective medical record review.
Background: There is absence of specific biomarkers and an incomplete understanding of the pathophysiology of exudative age-related macular degeneration (AMD).
Methods and findings: Eighty-eight vitreous samples (73 from patients with treatment naïve AMD and 15 control samples from patients with idiopathic floaters) were analyzed with capillary electrophoresis coupled to mass spectrometry in this retrospective case series to define potential candidate protein markers of AMD. Nineteen proteins were found to be upregulated in vitreous of AMD patients. Most of the proteins were plasma derived and involved in biological (ion) transport, acute phase inflammatory reaction, and blood coagulation. A number of proteins have not been previously associated to AMD including alpha-1-antitrypsin, fibrinogen alpha chain and prostaglandin H2-D isomerase. Alpha-1-antitrypsin was validated in vitreous of an independent set of AMD patients using Western blot analysis. Further systems biology analysis of the data indicated that the observed proteomic changes may reflect upregulation of immune response and complement activity.
Conclusions: Proteome analysis of vitreous samples from patients with AMD, which underwent an intravitreal combination therapy including a core vitrectomy, steroids and bevacizumab, revealed apparent AMD-specific proteomic changes. The identified AMD-associated proteins provide some insight into the pathophysiological changes associated with AMD.