Refine
Year of publication
Document Type
- Article (39)
- Preprint (20)
- Conference Proceeding (1)
- Doctoral Thesis (1)
Language
- English (61)
Has Fulltext
- yes (61)
Is part of the Bibliography
- no (61)
Keywords
- e +-e − Experiments (5)
- Particle and Resonance Production (3)
- BESIII (2)
- CC16 (2)
- Complication management (2)
- Exotics (2)
- Fistula (2)
- Flaps (2)
- Grafts (2)
- Maxillary sinus (2)
- Oral surgery (2)
- Oroantral (2)
- Quarkonium (2)
- Spectroscopy (2)
- alveolar ridge augmentation (2)
- animal experiment (2)
- uteroglobin (2)
- Alveolar ridge augmentation (1)
- Animal model (1)
- Bone remodelling (1)
- Bone substitute (1)
- Born cross section measurement (1)
- Branching fraction (1)
- CLP (1)
- COVID-19 (1)
- CP violation (1)
- Calcium (1)
- Charm Physics (1)
- Charmed mesons (1)
- Charmonium (-like) (1)
- Chemorefractory advanced gastric cancer (1)
- Clinical study (1)
- Computerlinguistik (1)
- Dark photon (1)
- Dark sector (1)
- Decision (1)
- Electroweak Interaction (1)
- Electroweak interaction (1)
- FOLFIRI (1)
- FOS: Physical sciences (1)
- Flavor symmetries (1)
- Generic NLP Architecture (1)
- HPSG Parsing (1)
- Hadronic decays (1)
- High Energy Physics - Experiment (hep-ex) (1)
- Histological analysis (1)
- IE (1)
- Implant osseointegration (1)
- Invisible decays (1)
- Laser-produced plasmas (1)
- Lepton colliders (1)
- Nephrons (1)
- Oncology (1)
- Oroantral communication (1)
- PRF (1)
- Pain management (1)
- Plasma-based accelerators (1)
- Platelet-rich fibrin (1)
- Polarization (1)
- QCD (1)
- Radical nephrectomy (1)
- Renal cancer (1)
- Renal system (1)
- Ridge preservation (1)
- Ryanodin (1)
- SARS-CoV-2 (1)
- SERCA (1)
- Shallow NLP (1)
- Socket healing (1)
- Socket preservation (1)
- Soft tissue healing (1)
- Sunitinib (1)
- Surgical and invasive medical procedures (1)
- Surgical oncology (1)
- Survival analysis (1)
- Tooth transplantation (1)
- Tyrosine kinase inhibitor (1)
- VEGF (1)
- XML (1)
- Y states (1)
- acute lung injury (1)
- acute lung injury (ALI) (1)
- animal experiments (1)
- antiresorptive agents (1)
- bone (1)
- bone‐screw (1)
- charmonium-like states (1)
- chest injury (1)
- chest trauma (1)
- clinical study (1)
- coronavirus (1)
- dental emergency treatment (1)
- dental implant (1)
- edentulous (1)
- electron-positron collision (1)
- elegans (1)
- extraction socket healing (1)
- full-arch restoration (1)
- hadron spectroscopy (1)
- helicity amplitude analysis (1)
- histological technic (1)
- implant movement (1)
- implant stability (1)
- in vivo micro‐CT (1)
- inflammation (1)
- macrophages (1)
- micro CT (1)
- monocytes (1)
- morphometry (1)
- orthodontic mini‐implant (1)
- patient questionnaire (1)
- patient triage (1)
- peri-implant disease (1)
- peri-implantitis treatment (1)
- prevalence (1)
- ridge preservation (1)
- sepsis (1)
- soft tissue (1)
- systematic review (1)
- tetraquark (1)
- tooth autotransplantation (1)
- tooth transplantation (1)
Institute
- Physik (40)
- Medizin (19)
- Biochemie, Chemie und Pharmazie (1)
- Extern (1)
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.