Refine
Author
- Grünwald, Frank (11)
- Happel, Christian (6)
- Sabet, Amir (6)
- Gröner, Daniel (5)
- Mader, Nicolai (5)
- Baumgarten, Justus (4)
- Tselis, Nikolaos (4)
- Chun, Felix (3)
- Nguyen Ngoc, Christina (3)
- Banek, Séverine (2)
- Bechstein, Wolf Otto (2)
- Bockisch, Benjamin (2)
- Davis, Karen (2)
- Wichert, Jennifer (2)
- Abazov, V. (1)
- Abdel-Rahman, Ulf (1)
- Abramov, V. (1)
- Achenbach, P. (1)
- Ackermann, Hanns (1)
- Ahmed, Samer (1)
- Akram, A. (1)
- Al-Turany, Mohammad (1)
- Albrecht, Malte (1)
- Alexeev, G. (1)
- Ali, A. (1)
- Alkakhi, W. (1)
- Amsler, C. (1)
- Andersson, W. Ikegami (1)
- Antokhin, E. (1)
- Arefiev, V. A. (1)
- Astakhov, V. (1)
- Atac, A. (1)
- Augustin, I. (1)
- Aybek, Tayfun (1)
- Azizi, K. (1)
- Badenhoop, Klaus (1)
- Balanutsa, P. (1)
- Balashoff, A. (1)
- Barabanov, M. Yu. (1)
- Barnyakov, A. Yu. (1)
- Barucca, Gianni (1)
- Basant, K. N. (1)
- Batyunya, B. V. (1)
- Beck, R. (1)
- Belias, A. (1)
- Beloborodov, K. (1)
- Belostotski, S. (1)
- Belousov, A. (1)
- Bettner, Y. (1)
- Bettoni, Diego (1)
- Bianchi, Nicola (1)
- Bianconi, A. (1)
- Biersack, Hans-Jürgen (1)
- Bittenbring, Jörg Thomas (1)
- Bitu-Moreno, José (1)
- Bleser, S. (1)
- Blinov, A. E. (1)
- Blinov, V. E. (1)
- Boca, Gianluigi (1)
- Bodenschatz, S. (1)
- Bonaventura, D. (1)
- Boukharov, A. (1)
- Bracco, G. (1)
- Bragadireanu, Mario (1)
- Brand, P. (1)
- Branford, D. (1)
- Brinkmann, K. T. (1)
- Brück, L. (1)
- Bukreeva, S. (1)
- Bumrungkoh, D. (1)
- Bussa, M. P. (1)
- Bäck, T. (1)
- Böhm, M. (1)
- Böhm, R. (1)
- Bökelmann, S. (1)
- Bölting, M. (1)
- Bühler, Paul (1)
- Calen, H. (1)
- Calvo, D. (1)
- Cao, N. (1)
- Cao, X. (1)
- Capozza, L. (1)
- Cederwall, B. (1)
- Chaurasia, Maximilian (1)
- Chernetsky, V. (1)
- Chernichenko, S. (1)
- Chlopik, A. (1)
- Ciesek, Sandra (1)
- Coen, S. (1)
- Corell, O. (1)
- Crede, V. (1)
- Damm, Dominik (1)
- Davì, F. (1)
- Dbeyssi, A. (1)
- De Remigis, P. (1)
- Deepak, P. N. (1)
- Demekhin, A. (1)
- Denig, Achim (1)
- Denizli, H. (1)
- Deppe, H. (1)
- Derevschikov, A. (1)
- Derichs, A. (1)
- Diehl, S. (1)
- Distler, M. (1)
- Dobbs, S. (1)
- Dodokhov, V. Kh. (1)
- Dolgolenko, A. (1)
- Dolles, Simon (1)
- Domagala, M. (1)
- Dormenev, V. (1)
- Dosdall, R. (1)
- Duda, D. (1)
- Dutta, K. (1)
- Dzhygadlo, R. (1)
- Döring, Claudia (1)
- Düren, M. (1)
- Eberlein, Valentina (1)
- Eckenschwiller, Manuel (1)
- Efremov, A. (1)
- Ehret, A. (1)
- Eichler, Jutta (1)
- Ensser, Armin (1)
- Er, N. (1)
- Erlen, T. (1)
- Erni, W. (1)
- Esmail, W. (1)
- Eugenio, P. (1)
- Eyrich, W. (1)
- Ezziddin, Samer (1)
- Farivar Tanha, Nadine (1)
- Fechtchenko, A. (1)
- Fedorets, P. (1)
- Fedorov, A. (1)
- Fedotov, G. (1)
- Fehre, Niklas (1)
- Feldbauer, Florian (1)
- Ferapontov, V. (1)
- Filippi, A. (1)
- Filo, G. (1)
- Finger, M. (1)
- Fink, M. (1)
- Firlej, M. (1)
- Fiutowski, T. (1)
- Flemming, H. (1)
- Fraedrich, Kirsten (1)
- Francischetti, Ieda (1)
- Frech, J. (1)
- Freudenreich, V. (1)
- Fritsch, Miriam (1)
- Fritzsch, C. (1)
- Föhl, K. (1)
- Gallus, P. (1)
- Galoyan, A. (1)
- Gandhi, K. (1)
- Gavrilov, G. (1)
- Gerasimov, A. (1)
- Gerhardt, A. (1)
- Gianotti, Paola (1)
- Gillitzer, A. (1)
- Glazier, D. (1)
- Godre, S. (1)
- Goldenbaum, F. (1)
- Golovanov, G. (1)
- Golubev, A. (1)
- Goncharenko, Y. (1)
- Goryachev, V. (1)
- Grieser, S. (1)
- Grochowski, J. (1)
- Grunwald, D. (1)
- Grunwald, Thomas (1)
- Grüner, Eva (1)
- Götzen, Klaus (1)
- Habenicht, Katharina (1)
- Haefele, Sebastian (1)
- Hagdorn, R. (1)
- Hahn, C. (1)
- Halstenberg, Jörg (1)
- Hamdi, A. (1)
- Hammann, C. (1)
- Hansmann, Martin-Leo (1)
- Hargens, C. (1)
- Hartmann, J. (1)
- Hauke, Manuela (1)
- Hayrapetyan, A. (1)
- Heinsius, Fritz-Herbert (1)
- Heinz, Andreas (1)
- Held, T. (1)
- Hergemöller, A. K. (1)
- Herold, Christoph (1)
- Hetz, B. (1)
- Himmelreich, Mathilde (1)
- Hoek, M. (1)
- Hoffmann, Markus (1)
- Hofmann, J. (1)
- Holtmann, Tobias (1)
- Holzer, Katharina (1)
- Hu, Q. (1)
- Huang, G. (1)
- Hunter, G. (1)
- Hüsken, Nils (1)
- Iazzi, F. (1)
- Idzik, M. (1)
- Ireland, D. (1)
- Isaksson, L. (1)
- Issmail, Leila (1)
- Izotov, A. (1)
- Jary, V. (1)
- Jiang, P. (1)
- Johansson, Tord (1)
- Jokhovets, L. (1)
- Jäck, Hans-Martin (1)
- Kalita, K. (1)
- Kannika, J. (1)
- Kantsyrev, A. (1)
- Kappert, R. (1)
- Karabowicz, R. (1)
- Kavatsyuk, Myroslav O. (1)
- Kazlou, D. (1)
- Kegel, S. (1)
- Kellers, J. (1)
- Keshk, I. (1)
- Kesik, G. (1)
- Keskin, U. (1)
- Kesselkaul, M. (1)
- Ketzer, Bernhard (1)
- Khosonthongkee, K. (1)
- Khoukaz, Alfons (1)
- Khreish, Fadi (1)
- Kirin, D. Y. (1)
- Kisel, Ivan (1)
- Klasen, R. (1)
- Kliemt, Ralf (1)
- Klimek, Konrad (1)
- Kobdaj, Chinorat (1)
- Koch, H. (1)
- Koch, S. (1)
- Kononov, S. (1)
- Kopf, Bertram (1)
- Korchak, O. (1)
- Korcyl, G. (1)
- Korcyl, K. (1)
- Korkusuz, Hüdayi (1)
- Korkusuz, Yücel (1)
- Korzhik, M. (1)
- Koshurnikov, E. K. (1)
- Kozela, A. (1)
- Kozlov, Grigory (1)
- Kranert, Tilmann (1)
- Kranert, Wolfgang Tilman (1)
- Kravchenko, E. A. (1)
- Krebs, M. (1)
- Kripko, A. (1)
- Kristi, N. (1)
- Krusche, B. (1)
- Kuhlmann, M. (1)
- Kulessa, P. (1)
- Kulkarni, A. (1)
- Kumawat, H. (1)
- Kunze, M. (1)
- Kupsc, Andrzej (1)
- Kurilla, U. (1)
- Kuyanov, I. A. (1)
- Kveton, A. (1)
- Köseoglu, I. (1)
- Kühn, Wolfgang (1)
- Kümmel, M. (1)
- Küßner, M. (1)
- Ladygina, E. (1)
- Lalik, R. (1)
- Lancioni, G. (1)
- Lange, Jens Sören (1)
- Lattery, M. (1)
- Lauth, W. (1)
- Lavagno, A. (1)
- Lebiedowicz, P. (1)
- Lehmann, A. (1)
- Lehmann, D. (1)
- Lehmann, I. (1)
- Leithoff, H. H. (1)
- Lersch, D. (1)
- Levin, A. (1)
- Li, H. (1)
- Li, J. (1)
- Li, Z. (1)
- Liang, Y. (1)
- Limphirat, A. (1)
- Linzen, L. (1)
- Lisowski, E. (1)
- Lisowski, F. (1)
- Liu, B. (1)
- Liu, C. (1)
- Liu, D. (1)
- Liu, Z. (1)
- Lobanov, Y. Yu. (1)
- Loehner, H. (1)
- Lucherini, V. (1)
- Luschevskaya, E. (1)
- Lynen, U. (1)
- Lögters, Tim Tobias (1)
- Lühning, J. (1)
- Ma, X. (1)
- Maas, F. (1)
- Mader, Felix Hans Alexander (1)
- Mader, Oscar Maximilian (1)
- Makonyi, K. (1)
- Maldaner, Stephan (1)
- Malige, A. (1)
- Malyshev, O. (1)
- Manaenkov, S. (1)
- Manasatitpong, K. (1)
- Mandel, Philipp (1)
- Mannweiler, C. (1)
- Marciniewski, P. (1)
- Marcisovsky, M. (1)
- Margraf, Stefan (1)
- Martin, A. (1)
- Marton, J. (1)
- Maslova, E. (1)
- Matveev, V. A. (1)
- Mazza, G. (1)
- McKay, Paul F. (1)
- Melnik, Y. (1)
- Melnychuk, D. (1)
- Mengucci, P. (1)
- Merkel, H. (1)
- Messchendorp, J. (1)
- Metag, V. (1)
- Meščanin, Aleksei P. (1)
- Michałek, M. (1)
- Miehling, D. (1)
- Mielenz, Dirk Alexander (1)
- Miklukho, O. (1)
- Minaev, N. (1)
- Missevitch, O. (1)
- Mochalov, V. (1)
- Moiseev, V. (1)
- Montalto, L. (1)
- Moritz, Anton (1)
- Moritz, M. (1)
- Moron, J. (1)
- Morozov, D. (1)
- Moskal, P. (1)
- Motzko, C. (1)
- Müller, U. (1)
- Müller-Schmucker, Sandra (1)
- Müllers, J. (1)
- Nagarajah, James (1)
- Nakhoul, S. (1)
- Nalti, W. (1)
- Nanova, M. (1)
- Nasawad, T. (1)
- Natali, P. P. (1)
- Neipel, Frank (1)
- Nerling, Frank (1)
- Neue, G. (1)
- Nguyen, Cam Tu (1)
- Nogach, L. (1)
- Noll, O. (1)
- Novotny, R. (1)
- Novy, J. (1)
- Nowakowski, K. (1)
- Olgun, A. T. (1)
- Olshevskiy, A. G. (1)
- Oppotsch, J. (1)
- Orfanitski, S. (1)
- Orsich, P. (1)
- Orth, H. (1)
- Pace, H. (1)
- Panjushkin, V. (1)
- Pankonin, S. (1)
- Pantea, D. (1)
- Paone, N. (1)
- Papenbrock, Michael (1)
- Pelizäus, Marc (1)
- Peng, H. (1)
- Penna Martinez, Marissa (1)
- Pereira-de-Lira, J. (1)
- Pesek, M. (1)
- Peskova, M. (1)
- Peter, Antonia Sophia (1)
- Peter, M. (1)
- Peterhoff, David (1)
- Peters, Klaus (1)
- Pfaffinger, M. (1)
- Pflüger, S. (1)
- Piskun, A. A. (1)
- Pitka, A. (1)
- Pivovarov, S. (1)
- Piñeiro, D. Rodríguez (1)
- Pochodzalla, J. (1)
- Pongampai, S. (1)
- Poslavskiy, S. (1)
- Pothodi Chackara, V. (1)
- Poznański, P. (1)
- Prasuhn, D. (1)
- Prencipe, E. (1)
- Preston, M. (1)
- Prochazka, I. (1)
- Przygoda, W. (1)
- Pugach, M. (1)
- Pyata, E. (1)
- Pysz, K. (1)
- Pérez Andrade, G. (1)
- Pöhlmann, Stefan (1)
- Pütz, J. (1)
- Płażek, J. (1)
- Qi, H. (1)
- Quin, N. (1)
- Rai, A. K. (1)
- Rathod, N. (1)
- Regina, J. (1)
- Reher, J. (1)
- Reicherz, G. (1)
- Richel, Elie (1)
- Rieger, J. (1)
- Rigato, V. (1)
- Rinaldi, D. (1)
- Ritman, J. (1)
- Rivetti, Angelo (1)
- Robison, L. (1)
- Rodin, Viktor (1)
- Rosenthal, E. (1)
- Rossbach, M. (1)
- Roth, Edith (1)
- Roy, B. (1)
- Roy, U. (1)
- Rudy, Z. (1)
- Ryazantsev, A. (1)
- Ryzhikov, S. (1)
- Röhlen, Natascha (1)
- Sachs, M. (1)
- Saito, T. (1)
- Salabura, P. (1)
- Salisbury, B. (1)
- Samartsev, A. (1)
- Saxena, Alok (1)
- Scalise, L. (1)
- Schadmand, S. (1)
- Schakel, P. (1)
- Schepers, G. (1)
- Schlimme, S. (1)
- Schmidt, C. J. (1)
- Schmidt, Christian Joachim (1)
- Schmidt, M. (1)
- Schmitt, L. (1)
- Schmitz, R. (1)
- Schnier, Claudius (1)
- Scholl, A. (1)
- Scholz, Martin (1)
- Schubert, R. (1)
- Schuh, Wolfgang (1)
- Schulz, Sebastian R. (1)
- Schupp, F. (1)
- Schwarz, C. (1)
- Schwiening, J. (1)
- Schäfer, W. (1)
- Schönning, K. (1)
- Sefzick, T. (1)
- Seitz, B. (1)
- Semenov, P. (1)
- Sennert, Michael (1)
- Serdyuk, V. (1)
- Seth, K. (1)
- Sfienti, C. (1)
- Shattock, Robin J. (1)
- Shein, I. (1)
- Shen, X. (1)
- Shimanski, S. (1)
- Simantathammakul, T. (1)
- Skachkov, N. B. (1)
- Skachkova, A. N. (1)
- Slunecka, M. (1)
- Smyrski, J. (1)
- Socher, Eileen (1)
- Spataro, Stefano (1)
- Srisawad, P. (1)
- Stavinskiy, A. V. (1)
- Steinacher, M. (1)
- Steinen, M. (1)
- Steinke, M. (1)
- Steinmetz, Tobit (1)
- Steinschaden, D. (1)
- Stenzel, H. (1)
- Sticht, Heinrich (1)
- Stockmanns, T. (1)
- Straube, M. (1)
- Strickert, M. (1)
- Strokovsky, E. A. (1)
- Sun, S. (1)
- Sun, Y. (1)
- Swientek, K. (1)
- Szczurek, A. (1)
- Tao, J. (1)
- Tarasiuk, J. (1)
- Tavukoglu, Z. (1)
- Tegner, P. E. (1)
- Tenbusch, Matthias (1)
- Terlecki, P. (1)
- Thiel, M. (1)
- Thoma, U. (1)
- Thöring, U. (1)
- Tikhonov, Y. (1)
- Tokmenin, V. (1)
- Tomasek, L. (1)
- Tomasek, M. (1)
- Tomasi-Gustafsson, E. (1)
- Traxler, M. (1)
- Triffterer, T. (1)
- Täschner, Alexander (1)
- Uhlig, Nadja (1)
- Urban, M. (1)
- Uzhinsky, V. (1)
- Uzunian, A. (1)
- Varentsov, V. (1)
- Vasiliev, Andrey (1)
- Vejdani, S. (1)
- Veretennikov, D. (1)
- Verkheev, A. (1)
- Vestrick, S. (1)
- Virius, M. (1)
- Vodopianov, A. (1)
- Volf, M. (1)
- Vorländer, Christian (1)
- Voss, B. (1)
- Vrba, V. (1)
- Wagner, Ralf (1)
- Walford, N. (1)
- Wasem, T. (1)
- Watts, D. (1)
- Wenzel, C. (1)
- Wheadon, R. (1)
- Widmann, Eberhard (1)
- Wieczorek, P. (1)
- Wiedner, Ulrich (1)
- Windolf, Joachim (1)
- Winkler, Thomas H. (1)
- Wintz, P. (1)
- Wohlfahrt, B. (1)
- Wojciechowski, M. (1)
- Wolff, S. (1)
- Wolke, M. (1)
- Wongprachanukul, N. (1)
- Wronka, S. (1)
- Wölbing, D. (1)
- Wölfel, Roman (1)
- Wüstner, P. (1)
- Xiao, T. (1)
- Xiong, X. A. (1)
- Xu, H. (1)
- Yabsley, B. (1)
- Yakutin, A. (1)
- Yan, Y. (1)
- Yerlikaya, S. (1)
- Yilmaz, A. (1)
- Yogesh, S. (1)
- Yu, C. (1)
- Zambrana, M. (1)
- Zaunick, H. G. (1)
- Zhang, X. (1)
- Zhao, G. (1)
- Zhao, J. (1)
- Zhdanov, A. (1)
- Zhou, X. (1)
- Zhou, Y. (1)
- Zhu, W. (1)
- Zhuravlev, N. I. (1)
- Zimmermann, I. (1)
- Zimmermann, S. (1)
- Zmeskal, Johann (1)
- Zwieglinski, B. (1)
- Zyzak, Maksym (1)
- Überla, Klaus Thomas (1)
Document Type
- Article (13)
Language
- English (13) (remove)
Has Fulltext
- yes (13)
Is part of the Bibliography
- no (13)
Keywords
- 177Lu-PSMA-617 (4)
- PSMA (4)
- metastatic castration-resistant prostate cancer (2)
- 223Radium-dichloride (1)
- 99mTc-MIBI (1)
- 99mTc-pertechnetate (1)
- COVID-19 (1)
- Effective half-life (1)
- FOXO3a (1)
- Graves’ disease (1)
Peter, Antonia Sophia ; Roth, Edith ; Schulz, Sebastian R. ; Fraedrich, Kirsten ; Steinmetz, Tobit ; Damm, Dominik ; Hauke, Manuela ; Richel, Elie ; Müller-Schmucker, Sandra ; Habenicht, Katharina ; Eberlein, Valentina ; Issmail, Leila ; Uhlig, Nadja ; Dolles, Simon ; Grüner, Eva ; Peterhoff, David ; Ciesek, Sandra ; Hoffmann, Markus ; Pöhlmann, Stefan ; McKay, Paul F. ; Shattock, Robin J. ; Wölfel, Roman ; Socher, Eileen ; Wagner, Ralf ; Eichler, Jutta ; Sticht, Heinrich ; Schuh, Wolfgang ; Neipel, Frank ; Ensser, Armin ; Mielenz, Dirk Alexander ; Tenbusch, Matthias ; Winkler, Thomas H. ; Grunwald, Thomas ; Überla, Klaus Thomas ; Jäck, Hans-Martin
TRIANNI mice carry an entire set of human immunoglobulin V region gene segments and are a powerful tool to rapidly isolate human monoclonal antibodies. After immunizing these mice with DNA encoding the spike protein of SARS-CoV-2 and boosting with spike protein, we identified 29 hybridoma antibodies that reacted with the SARS-CoV-2 spike protein. Nine antibodies neutralize SARS-CoV-2 infection at IC50 values in the subnanomolar range. ELISA-binding studies and DNA sequence analyses revealed one cluster of three clonally related neutralizing antibodies that target the receptor-binding domain and compete with the cellular receptor hACE2. A second cluster of six clonally related neutralizing antibodies bind to the N-terminal domain of the spike protein without competing with the binding of hACE2 or cluster 1 antibodies. SARS-CoV-2 mutants selected for resistance to an antibody from one cluster are still neutralized by an antibody from the other cluster. Antibodies from both clusters markedly reduced viral spread in mice transgenic for human ACE2 and protected the animals from SARS-CoV-2-induced weight loss. The two clusters of potent noncompeting SARS-CoV-2 neutralizing antibodies provide potential candidates for therapy and prophylaxis of COVID-19. The study further supports transgenic animals with a human immunoglobulin gene repertoire as a powerful platform in pandemic preparedness initiatives.
Röhlen, Natascha ; Döring, Claudia ; Hansmann, Martin-Leo ; Grünwald, Frank ; Vorländer, Christian ; Bechstein, Wolf Otto ; Holzer, Katharina ; Badenhoop, Klaus ; Penna Martinez, Marissa
Background: Protective effects of vitamin D have been reported in autoimmune and malignant thyroid diseases, though little is known about the underlying mechanism. Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis. Aim of the present study was to investigate common single nucleotide polymorphisms (SNP's) in FOXO3a gene in respect to thyroid diseases, as well as to evaluate the hypothesis of Sirtuin1-FOXO3a interaction being a mediator of anti-proliferative vitamin D effects.
Methods: The SNP's FOXO3a rs4946936/rs4945816/rs9400239 were genotyped in 257 patients with differentiated thyroid carcinoma (DTC), 139 patients with Hashimoto thyroiditis (HT) and 463 healthy controls (HC). Moreover, T-helper cells of HC and papillary thyroid cancer cell line BCPAP were incubated with 1,25(OH)2D3 and/or SIRT1 inhibitor Ex-527 in order to elucidate SIRT1- dependent vitamin D effects on cell proliferation and FOXO3a gene expression in vitro.
Results: Patients with DTC tended to carry more often allele C in FOXO3a rs4946936 in comparison to HC (pcorrected = pc = 0.08). FOXO3a rs9400239T and rs4945816C was more frequent in HT in comparison to HC (pc = 0.02 and pc = 0.01, respectively). In both DTC and HT, we could not find a correlation of FOXO3a SNP's with vitamin D status. However, on in vitro level, 1,25(OH)2D3 showed an anti-proliferative effect in both T-helper cells and BCPAP, that was blocked by SIRT1 inhibition (T-helper cells: p = 0.0059, BCPAP: p = 0.04) and accompanied by elevated FOXO3a gene expression in T-helper cells (p = 0.05).
Conclusions: FOXO3a rs9400239T and rs4945816C may constitute risk factors for HT, independent of the vitamin D status.This indicates the implication of FOXO3a in pathogenesis of autoimmune thyroid diseases. The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.
Sabet, Amir ; Mader, Nicolai ; Bittenbring, Jörg Thomas ; Khreish, Fadi ; Grünwald, Frank ; Biersack, Hans-Jürgen ; Ezziddin, Samer
Peptide receptor radionuclide therapy (PRRT) of metastatic neuroendocrine tumors (NET) can be successfully repeated but may eventually be dose-limited. Since 177Lu-DOTATATE dose limitation may come from hematological rather than renal function, hematological peripheral blood stem cell backup might be desirable. Here, we report our initial experience of peripheral blood stem-cell collection (PBSC) in patients with treatment-related cytopenia and therefore high risk of bone-marrow failure. Five patients with diffuse bone-marrow infiltration of NET and relevant myelosuppression (≥grade 2) received PBSC before one PRRT cycle with 177Lu-DOTATATE (7.6 ± 0.8 GBq/cycle). Standard stem-cell mobilization with Granulocyte-colony stimulating factor (G-CSF) was applied, and successful PBSC was defined as a collection of >2 × 106/kg CD34+ cells. In case of initial failure, Plerixafor was administered in addition to G-CSF prior to apheresis. PBSC was successfully performed in all patients with no adverse events. Median cumulative activity was 44.8 GBq (range, 21.3–62.4). Three patients had been previously treated with PRRT, two of which needed the addition of Plerixafor for stem-cell mobilization. Only one of five patients required autologous peripheral blood stem-cell transplantation during the median follow up time of 28 months. PBSC collection seems to be feasible in NET with bone-marrow involvement and might be worth considering as a backup strategy prior to PRRT, in order to overcome dose-limiting bone-marrow toxicity.