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Der Beitrag stellt am Beispiel der dritten Phase der Lehrer:innenbildung den Professionalisierungsansatz vor, der in dem Forschungs- und Entwicklungsprojekt „Reflexion, Leistung und Inklusion“ (ReLInk) konzipiert und in Fortbildungsworkshops für Lehrkräfte der Sekundarstufe I erprobt wurde. Nach einer Projektdarstellung (Abschnitt 1) werden ausgewählte Ergebnisse der im Rahmen von ReLInk durchgeführten qualitativen Studie vorgestellt (Abschnitt 2). Diese Ergebnisse bildeten den Ausgangspunkt für die Entwicklung kasuistischer Materialien für die Aus- und Fortbildung von (angehenden) Lehrkräften. Für die Gestaltung der Fortbildungsworkshops stellte die Arbeit mit der Methode der sequenzanalytischen praxisreflexiven Kasuistik den Kern des Professionalisierungsansatzes von ReLInk dar. Die Materialien stehen online in einem Open-Access-Themenheft zur Verfügung (Abschnitt 3). Hierzu werden Erfahrungen aus den Workshops und Ergebnisse einer qualitativen Evaluation dieses Ansatzes präsentiert (Abschnitt 4). Am Ende werden anschließende Fragen sowohl für die Professionalisierung sowie für die Forschung aufgeworfen (Abschnitt 5).
The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular blood-brain barrier (BBB), creating communication sites for sensory or secretory neurons, involved in body homeostasis. Wnt/β-catenin signaling is essential for BBB development and maintenance in endothelial cells (ECs) in most CNS vessels. Here we show that in mouse development, as well as in adult mouse and zebrafish, CVO ECs rendered Wnt-reporter negative, suggesting low level pathway activity. Characterization of the subfornical organ (SFO) vasculature revealed heterogenous claudin-5 (Cldn5) and Plvap/Meca32 expression indicative for tight and leaky vessels, respectively. Dominant, EC-specific β-catenin transcription in mice, converted phenotypically leaky into BBB-like vessels, by augmenting Cldn5+ vessels, stabilizing junctions and by reducing Plvap/Meca32+ and fenestrated vessels, resulting in decreased tracer permeability. Endothelial tightening augmented neuronal activity in the SFO of water restricted mice. Hence, regulating the SFO vessel barrier may influence neuronal function in the context of water homeostasis.
The decays J/ψ→ηΣ+Σ¯− and ψ(3686)→ηΣ+Σ¯− are observed for the first time, using (10087±44)×106 J/ψ and (448.1±2.9)×106 ψ(3686) events collected with the BESIII detector at the BEPCII collider. We determine the branching fractions of these two decays to be B(J/ψ→ηΣ+Σ¯−)=(6.34±0.21±0.37)×10−5 and B(ψ(3686)→ηΣ+Σ¯−)=(9.59±2.37±0.61)×10−6, where the first uncertainties are statistical and the second are systematic. The ratio of these two branching fractions is determined to be B(ψ(3686)→ηΣ+Σ¯−)B(J/ψ→ηΣ+Σ¯−)=(15.1±3.8)%, which is in agreement with the "12\% rule."
Using a data sample of e+e− collision data corresponding to an integrated luminosity of 19 fb−1 collected with the BESIII detector at the BEPCII collider, we search for the production of deuterons and antideuterons via e+e−→ppπ−d¯+c.c. for the first time at center-of-mass energies between 4.13 and 4.70 GeV. No significant signal is observed and the upper limit of the e+e−→ppπ−d¯+c.c. cross section is determined to be from 9.0 to 145 fb depending on the center-of-mass energy at the 90% confidence level.
Using 𝑒+𝑒− collision data corresponding to an integrated luminosity of 7.33 fb−1 recorded by the BESIII detector at center-of-mass energies between 4.128 and 4.226 GeV, we present an analysis of the decay 𝐷+𝑠→𝜋+𝜋−𝑒+𝜈𝑒, where the 𝐷+𝑠 is produced via the process 𝑒+𝑒−→𝐷*±𝑠𝐷∓𝑠. We observe the 𝑓0(980) in the 𝜋+𝜋− system and the branching fraction of the decay 𝐷+𝑠→𝑓0(980)𝑒+𝜈𝑒 with 𝑓0(980)→𝜋+𝜋− measured to be (1.72±0.13stat±0.10syst)×10−3, where the uncertainties are statistical and systematic, respectively. The dynamics of the 𝐷+𝑠→𝑓0(980)𝑒+𝜈𝑒 decay are studied with the simple pole parametrization of the hadronic form factor and the Flatté formula describing the 𝑓0(980) in the differential decay rate, and the product of the form factor 𝑓𝑓0+(0) and the 𝑐→𝑠 Cabibbo-Kobayashi-Maskawa matrix element |𝑉𝑐𝑠| is determined for the first time to be 𝑓𝑓0+(0)|𝑉𝑐𝑠|=0.504±0.017stat±0.035syst. Furthermore, the decay 𝐷+
𝑠→𝑓0(500)𝑒+𝜈𝑒 is searched for the first time but no signal is found. The upper limit on the branching fraction of 𝐷+𝑠→𝑓0(500)𝑒+𝜈𝑒, 𝑓0(500)→𝜋+𝜋− decay is set to be 3.3×10−4 at 90% confidence level.
Using a data sample corresponding to an integrated luminosity of 10.9 fb−1 collected at center-of-mass energies from 4.16 to 4.34 GeV with the BESIII detector, we search for the decay χc1(3872)→π+π−χc1 in the radiative production e+e−→γχc1(3872). No significant signal is observed, and the ratio for the branching fraction of χc1(3872)→π+π−χc1 to χc1(3872)→π+π−J/ψ is measured as R≡B[χc1(3872)→π+π−χc1]B[χc1(3872)→π+π−J/ψ]<0.18 at 90% confidence level. The upper limit on the product of the cross section σ[e+e−→γχc1(3872)] and the branching fraction B[χc1(3872)→π+π−χc1] at each center-of-mass energy is also given. These measurements favor the non-conventional charmonium nature of the χc1(3872) state.
A narrow structure in the pΛ¯ system near the mass threshold, named as X(2085), is observed in the process e+e−→pK−Λ¯ with a statistical significance greater than 20σ. Its spin and parity are determined for the first time to be JP=1+ in an amplitude analysis, with statistical significance greater than 5σ over other quantum numbers. The pole positions of X(2085) are measured to be Mpole=(2086±4±6)~MeV and Γpole=(56±5±16) MeV, where the first uncertainties are statistical and the second ones are systematic. The analysis is based on the study of the process e+e−→pK−Λ¯ and uses the data samples collected with the BESIII detector at the center-of-mass energies s√=4.008, 4.178, 4.226, 4.258, 4.416, and 4.682 GeV with a total integrated luminosity of 8.35 fb−1.
Based on a sample of 448.1×106 ψ(3686) events collected with the BESIII detector, a study of ψ(3686)→ΛΛ¯π0 and ψ(3686)→ΛΛ¯η is performed. Evidence of the isospin-violating decay ψ(3686)→ΛΛ¯π0 is found for the first time with a statistical significance of 3.7σ, the branching fraction B(ψ(3686)→ΛΛ¯π0) is measured to be (1.42±0.39±0.59)×10−6, and its corresponding upper limit is determined to be 2.47×10−6 at 90\% confidence level. A partial wave analysis of ψ(3686)→ΛΛ¯η shows that the peak around Λη invariant mass threshold favors a Λ∗ resonance with mass and width in agreement with the Λ(1670). The branching fraction of the ψ(3686)→ΛΛ¯η is measured to be (2.34±0.18±0.52)×10−5. The first uncertainties are statistical and the second are systematic.
Based on e+e− collision data corresponding to an integrated luminosity of 4.5 fb−1 collected at the center-of-mass energies between 4.600 and 4.699 GeV with the BESIII detector at BEPCII, the absolute branching fraction of the inclusive decay Λ+c→n+X, where X refers to any possible final state particles, is measured. The absolute branching fraction is determined to be B(Λ+c→n+X)=(32.4±0.7±1.5)%, where the first uncertainty is statistical and the second systematic. Assuming CP symmetry, the measurement indicates that about one-fourth of Λ+c (Λ¯−c) decay modes with a neutron (an anti-neutron) in the final state have not been observed.
Based on e+e− collision data corresponding to an integrated luminosity of 4.5 fb−1 collected at the center-of-mass energies between 4.600 and 4.699 Gev with the BESIII detector at BEPCII, the absolute branching fraction of the inclusive decay Λ¯−c→n¯+X, where X refers to any possible final state particles, is measured. The absolute branching fraction is determined to be B(Λ¯−c→n¯+X)=(33.5±0.7±1.2)%, where the first uncertainty is statistical and the second systematic. Neglecting the effect of CP violation, the measurement indicates that about one-fourth of Λ+c decay modes with a neutron in the final state have not been observed.