Refine
Year of publication
Document Type
- Article (47)
- Preprint (14)
- Working Paper (2)
Has Fulltext
- yes (63)
Is part of the Bibliography
- no (63)
Keywords
- LHC (3)
- ALICE (2)
- Shell model (2)
- 900 GeV (1)
- Aeroplysinin-1 (1)
- Cardiac implantable electronic devices (1)
- Cardiac rehabilitation (1)
- Cardiac resynchronization therapy (1)
- Consensus document (1)
- Desmin (1)
- Direct reactions (1)
- Electron-pion identification (1)
- Epidermolysis bullosa simplex with muscular dystrophy (1)
- Epithelioma Cells (1)
- Exercise training (1)
- Extracurricular Activities (1)
- Femtoscopy (1)
- Fibre/foam sandwich radiator (1)
- Financial Industry (1)
- Genetics (1)
- Genome-wide association studies (1)
- Great cormorant (1)
- HBT (1)
- Heart failure (1)
- Heavy Ions (1)
- Heavy-ion collisions (1)
- High-energy neutron detection (1)
- Implantable cardioverter-defibrillator (1)
- Intensity interferometry (1)
- Intermediate filaments (1)
- Inverse kinematics (1)
- Ionisation energy loss (1)
- Labor Markets (1)
- Lake Dümmer (1)
- Lymphoma Cells (1)
- Mitochondria (1)
- Multi-neutron detection (1)
- Multi-wire proportional drift chamber (1)
- Neural network (1)
- Nuclear modification factor (1)
- Nuclear reactions (1)
- Nuclear structure & decays (1)
- Nucleon induced nuclear reactions (1)
- PYTHIA (1)
- Pacemaker (1)
- Pb–Pb (1)
- Physical activity (1)
- Plastic scintillator array (1)
- Plectin (1)
- Prevention (1)
- Protein aggregates (1)
- Public Goods (1)
- QCD (1)
- Quark gluon plasma (1)
- Quasi-free scattering (1)
- Reactions with relativistic radioactive beams (1)
- Red blood cell transfusion (1)
- SARS-CoV-2 (1)
- Selection (1)
- Signaling (1)
- Skeletal muscle (1)
- Spectroscopic factors (1)
- Spectroscopic factors & electromagnetic moments (1)
- TR (1)
- Tracking (1)
- Transition radiation detector (1)
- Transverse momentum (1)
- Trigger (1)
- Trust (1)
- Trustworthiness (1)
- Viral infection (1)
- Xenon-based gas mixture (1)
- anaemia (1)
- atrial fibrillation (1)
- bortezomib (1)
- catheter ablation (1)
- cryoballoon (1)
- dE/dx (1)
- diet patterns (1)
- eel (1)
- elderly patients (1)
- health economics (1)
- induction regimen (1)
- kidney (1)
- lenalidomide (1)
- multiple myeloma (1)
- pellet analysis (1)
- pikeperch (1)
- pulmonary vein isolation (1)
- renal failure (1)
- surgery (1)
- √sN N = 2.76 TeV (1)
Institute
- Physik (46)
- Frankfurt Institute for Advanced Studies (FIAS) (24)
- Informatik (24)
- Medizin (10)
- ELEMENTS (4)
- Center for Financial Studies (CFS) (2)
- Wirtschaftswissenschaften (2)
- Biowissenschaften (1)
- House of Finance (HoF) (1)
- Pharmazie (1)
(±)-Aeroplysinin-1, an optically active 1.2-dihydroarene-1.2-diol. was isolated from the marine sponges Verongia aerophoba (+-isomer) and lanthella ardis (--isomer). For the experiments presented we used the +-isomer from Verongia aerophoba. Here we describe the hitherto unknown biological and pharmacological property of this compound to display pronounced anticancer activity against L5178y mouse lymphoma cells (ED50: 0.5 μm). Friend erythroleukemia cells (ED50: 0.7μm) , human mamma carcinoma cells (ED50: 0.3μm) and human colon carcinoma cells (ED50: 3.0 μm) in vitro. Furthermore, aeroplysinin caused a preferential inhibition of [3H]thymidine (dThd) incorporation rates in L5178y mouse lymphoma cells if compared with murine spleen lymphocytes in vitro. At concentrations between 1.1 and 28.5 μm, the [3H]dThd incorporation rates in L5178y cells were suppressed to 28% -0% but only to 78% -18% in murine spleen lymphocytes. The same differential effect in vitro was found with the following epithelial cells: 14.70 μm of the compound were required to inhibit normal human fibroblasts to 50% , but only 2.9 μm in the assays with human malign keratinocytes or malignant melanoma cells to observe the same inhibitory effect. Moreover, aeroplysinin-1 displayed antileukemic activity in vivo using the L5178y cell/NMRI mouse system; administered at a dose of 50 mg/kg for five consecutive days, the T/C (% ) value was determined to be 338. Preliminary toxicology studies revealed an acute LD50 of 202 mg/kg and a subacute LD50 of 150 mg/kg. Aeroplysinin-1 is neither a direct mutagen nor a premutagen in the umu/Salmonella typhimurium test system.
We measured the Coulomb dissociation of 16O into 4He and 12C at the R3B setup in a first campaign within FAIR Phase 0 at GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt. The goal was to improve the accuracy of the experimental data for the 12C(α,γ)16O fusion reaction and to reach lower center-ofmass energies than measured so far.
The experiment required beam intensities of 109 16O ions per second at an energy of 500 MeV/nucleon. The rare case of Coulomb breakup into 12C and 4He posed another challenge: The magnetic rigidities of the particles are so close because of the same mass-to-charge-number ratio A/Z = 2 for 16O, 12C and 4He. Hence, radical changes of the R3B setup were necessary. All detectors had slits to allow the passage of the unreacted 16O ions, while 4He and 12C would hit the detectors' active areas depending on the scattering angle and their relative energies. We developed and built detectors based on organic scintillators to track and identify the reaction products with sufficient precision.
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.