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Minimal residual disease (MRD) is the strongest predictor of relapse in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In BLAST study (NCT01207388), adults with BCP-ALL in remission with MRD after chemotherapy received blinatumomab, a CD19 BiTE® immuno-oncotherapy, 15 µg/m2/day for up to four 6-week cycles (4 weeks continuous infusion, 2 weeks off). Survival was evaluated for 110 patients, including 74 who received HSCT in continuous complete remission. With a median follow-up of 59·8 months, median survival (months) was 36·5 (95% CI: 22.0–not reached [NR]). Median survival was NR (29.5–NR) for complete MRD responders (n = 84) and 14.4 (3.8–32.3) for MRD non-responders (n = 23; p = 0.002); after blinatumomab and HSCT, median survival was NR (25.7–NR) (n = 61) and 16.5 (1.1–NR) (n = 10; p = 0.065), respectively. This final analysis suggests complete MRD response during blinatumomab treatment is curative. Post-hoc analysis of study data suggests while post blinatumomab HSCT may be beneficial in appropriate patients, long-term survival without HSCT is also possible.
Während der Arbeit an den 'Thesen über den Begriff der Geschichte' hat Walter Benjamin den in der Geschichtsschreibung gebräuchlichen Begriff der "Quelle" einer radikalen Kritik unterworfen, die die Formen der Überlieferung überhaupt infrage stellt. Statt sich an das Schauspiel eines Stroms der Überlieferung zu verlieren, zu dem sich die Quellen vereinigt haben, frage der historische Materialist danach, wessen Mühlen der Strom treibe, wer sein Gefälle verwerte, wer ihn eindämmte, und indem er die Kräfte beim Namen nenne, "die in ihr am Werke gewesen sind", verändere er "das Bild der Landschaft" (GS I, 1160 f.). Diese Kritik sieht die "Quellen" in einen selber von Interessen und Macht bestimmten, weitgehend 'verderbten' Prozess der Überlieferung eingebunden. In der echten Geschichtsschreibung, heißt es in einem Entwurf der 'Thesen', erwachse daraus, und eben so stark wie ihr destruktiver Impuls, "der Impuls der Rettung", nicht nur vor "dem Verruf und der Mißachtung", in die Gewesenes geraten ist, sondern eben "vor einer bestimmten Art seiner Überlieferung" (WuN XIX, 128) selber. Der Begriff der "Quelle" gehört für Benjamin einer positivistisch verstandenen 'reinen' Wissenschaft der Geschichte an; der "wissenschaftliche" Charakter der Geschichte aber wird "erkauft mit der gänzlichen Ausmerzung alles dessen, was an ihre ursprüngliche Bestimmung als Eingedenken erinnert. Die falsche Lebendigkeit der Vergegenwärtigung, die Beseitigung jedes Nachhalls der 'Klage' aus der Geschichte bezeichnet ihre endgültige Unterwerfung unter den modernen Begriff der Wissenschaft." (GS I, 1231) Die 'Thesen' legen theoretisch-methodisch den Grund dafür, dass Referenztexte ganz anders aufgefasst werden als "Quellen" in einer begriffs- oder ideengeschichtlichen Darstellung. Wie aber dann, zumal in den 'Thesen' selber? Die Frage nach der Funktion der Referenzen in den 'Thesen' ist anders zu stellen als die nach einer Verwendung von Quellen, nämlich als die Frage danach, in welcher Weise Benjamin 'in' ihnen, 'mit' ihnen und 'gegen' sie denkt. So kommen auch die unterschiedlichen Formen der nicht explizit gemachten, verborgenen Referenzen ins Spiel.
The Born cross sections of the e+e− → D*+D*− and e+e− → D*+D− processes are measured using e+e− collision data collected with the BESIII experiment at center-of-mass energies from 4.085 to 4.600 GeV, corresponding to an integrated luminosity of 15.7 fb−1. The results are consistent with and more precise than the previous measurements by the Belle, Babar and CLEO collaborations. The measurements are essential for understanding the nature of vector charmonium and charmonium-like states.
Using 7.33 fb−1 of e+e− collision data collected by the BESIII detector at center-of-mass energies between 4.128 and 4.226~GeV, we observe for the first time the decay D±s→ωπ±η with a statistical significance of 7.6σ. The measured branching fraction of this decay is (0.54±0.12±0.04)%, where the first uncertainty is statistical and the second is systematic.
We present the first experimental search for the rare charm decay D0→π0ν¯ν. It is based on an e+e− collision sample consisting of 10.6×10^6 pairs of D0¯D0 mesons collected by the BESIII detector at √s=3.773 GeV, corresponding to an integrated luminosity of 2.93 fb^−1. A data-driven method is used to ensure the reliability of the background modeling. No significant D0→π0ν¯ν signal is observed in data and an upper limit of the branching fraction is set to be 2.1×10^-4 at the 90% confidence level. This is the first experimental constraint on charmed-hadron decays into dineutrino final states.
We report the first measurements of the absolute branching fractions of D0 → K0 Lϕ, D0 → K0Lη, D0 → K0Lω, and D0 → K0Lη0, by analyzing 2.93 fb−1 of eþe− collision data taken at a center-of-mass energy of 3.773 GeV with the BESIII detector. Taking the world averages of the branching fractions of D0 → K0Sϕ, D0 → K0Sη, D0 → K0Sω, and D0 → K0Sη0, the K0S − K0L asymmetries RðD0; XÞ in these decay modes are obtained. The CP asymmetries in these decays are also determined. No significant CP violation is observed
We report the measurement of the cross sections for e+e−→hadrons at center-of-mass (c.m.) energies from 3.645 to 3.871 GeV. We observe a new resonance R(3810) in the cross sections for the first time, and observe the R(3760) resonance with high significance in the cross sections. The R(3810) has a mass of (3804.5±0.9±0.9) ~MeV/c2, a total width of (5.4±3.5±3.2)~MeV, and an electronic partial width of (19.4±7.4±12.1)~eV. Its significance is 7.7σ. The R(3810) could be interpreted as a hadro-charmonium resonance predicted by Quantum Chromodynamics (QCD). In addition, we measure the mass (3751.9±3.8±2.8) ~MeV/c2, the total width (32.8±5.8±8.7)~MeV, and the electronic partial width (184±75±86)~eV with improved precision for the R(3760). Furthermore, for the R(3780) we measure the mass (3778.7±0.5±0.3) ~MeV/c2 and total width (20.3±0.8±1.7)~MeV with improved precision, and the electronic partial width (265±69±83)~eV. The R(3780) can be interpreted as the 13D1 state of charmonium. Its mass and total width differ significantly from the corresponding fitted values given by the Particle Data Group in 2022 by 7.1 and 3.2 times the uncertainties for ψ(3770), respectively. ψ(3770) has been interpreted as the 13D1 state for 45 years.
We search for an axion-like particle (ALP) a through the process ψ(3686)→π+π−J/ψ, J/ψ→γa, a→γγ in a data sample of (2.71±0.01)×109 ψ(3686) events collected by the BESIII detector. No significant ALP signal is observed over the expected background, and the upper limits on the branching fraction of the decay J/ψ→γa and the ALP-photon coupling constant gaγγ are set at 95% confidence level in the mass range of 0.165≤ma≤2.84GeV/c2. The limits on B(J/ψ→γa) range from 8.3×10−8 to 1.8×10−6 over the search region, and the constraints on the ALP-photon coupling are the most stringent to date for 0.165≤ma≤1.468GeV/c2.
A search has been performed for the semileptonic decays D0→K0SK−e+νe, D+→K0SK0Se+νe and D+→K+K−e+νe, using 7.9 fb−1 of e+e− annihilation data collected at the center-of-mass energy s√=3.773 GeV by the BESIII detector operating at the BEPCII collider. No significant signals are observed, and upper limits are set at the 90\% confidence level of 2.13×10−5, 1.54×10−5 and 2.10×10−5 for the branching fractions of D0→K0SK−e+νe, D+→K0SK0Se+νe and D+→K+K−e+νe, respectively.