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Characteristically, most solid tumors exhibit an increased tumor interstitial fluid pressure (TIFP) that directly contributes to the lowered uptake of macromolecular therapeutics into the tumor interstitium. Abnormalities in the tumor-associated lymph vessels are a central brick in the development and prolonged sustaining of an increased TIFP. In the current study, vascular endothelial growth factor C (VEGF-C) was used to enhance tumor-associated lymphangiogenesis as a new mechanism to actively reduce the TIFP by increased lymphatic drainage of the tumor tissue. Human A431 epidermoid vulva carcinoma cells were inoculated in NMRI nu/nu mice to generate a xenograft mouse model. Seven days after tumor cell injection, VEGF-C was peritumorally injected to induce lymphangiogenesis. Tumor growth and TIFP was lowered significantly over time in VEGF-C-treated tumors in comparison to control or VEGF-A-treated animals. These data demonstrate for the first time that actively induced lymphangiogenesis can lower the TIFP in a xenograft tumor model and apparently reduce tumor growth. This model represents a novel approach to modulate biomechanical properties of the tumor interstitium enabling a lowering of TIFP in vivo.
Auf 10 Jahre kann das Tochterunternehmen der Goethe-Universität nunmehr zurückblicken: INNOVECTIS ist zuständig für den erfolgreichen Transfer von akademischem Know-how in die wirtschaftliche Praxis. Wir haben anlässlich der Festveranstaltung auf dem Campus Westend dem Aufsichtsratsvorsitzenden Prof. Manfred Schubert-Zsilavecz, dem Vorsitzenden des Bewertergremiums, Prof. Jürgen Bereiter-Hahn, und dem Geschäftsführer Dr. Otmar Schöller einige Fragen gestellt.