Refine
Author
- Boon, Reinier (2)
- Mägdefessel, Lars (2)
- Pauli, Jessica (2)
- Abé, Christoph (1)
- Agartz, Ingrid (1)
- Akudjedu, Theophilus N. (1)
- Allen, Nicholas B. (1)
- Ames, David (1)
- Andre, Aleman (1)
- Andreassen, Ole A. (1)
- Arias Vásquez, Alejandro (1)
- Armstrong, Nicola J. (1)
- Bastin, Mark E. (1)
- Batalla, Albert (1)
- Bauer, Jochen (1)
- Baune, Bernhard T. (1)
- Baur, Ramona (1)
- Bergo, Felipe (1)
- Biederman, Joseph (1)
- Bink, Diewertje I. (1)
- Blaine, Sara K. (1)
- Boedhoe, Premika (1)
- Bose, Anushree (1)
- Bralten, Janita (1)
- Brandeis, Daniel (1)
- Brem, Silvia (1)
- Brodaty, Henry (1)
- Brooks, Samantha J. (1)
- Bröhl, Henrieke (1)
- Buitelaar, Jan K. (1)
- Busatto Filho, Geraldo (1)
- Busch, Albert Franz Jakob (1)
- Bøen, Erlend (1)
- Bülow, Robin (1)
- Bürger, Christian (1)
- Calhoun, Vince D. (1)
- Calvo, Anna (1)
- Canales-Rodrı́guez, Erick Jorge (1)
- Canive, Jose M. (1)
- Cannon, Dara M. (1)
- Caparelli, Elisabeth C. (1)
- Castellanos, Francisco X. (1)
- Cavalleri, Gianpiero L. (1)
- Cendes, Fernando (1)
- Cervenka, Simon (1)
- Chaim-Avancini, Tiffany Moukbel (1)
- Chantiluke, Kaylita (1)
- Chen, Qun-lin (1)
- Chen, Xiayu (1)
- Cheng, Yuqi (1)
- Christakou, Anastasia (1)
- Clark, Vincent P. (1)
- Coghill, David (1)
- Collste, Karin (1)
- Connolly, Colm G. (1)
- Conzelmann, Annette (1)
- Cousijn, Janna (1)
- Crivello, Fabrice (1)
- Crow, Tim (1)
- Cubillo, Ana (1)
- Cόrdova-Palomera, Aldo (1)
- Dannlowski, Udo (1)
- De Zubicaray, Greig (1)
- Deary, Ian J. (1)
- Delanty, Norman (1)
- Demeter, Damion V. (1)
- Di Martino, Adriana (1)
- Dickie, Erin W (1)
- Dietsche, Bruno (1)
- Doan, N. Trung (1)
- Doherty, Colin P. (1)
- Doyle, Alysa (1)
- Durston, Sarah (1)
- Earl, Eric (1)
- Eckstein, Hans-Henning (1)
- Ehrlich, Stefan (1)
- Eijk, Liza van (1)
- Ekman, Carl Johan (1)
- Elvsåshagen, Torbjørn (1)
- Engberg, Goran (1)
- Epstein, Jeffery N. (1)
- Erhardt, Sophie (1)
- Fair, Damien A. (1)
- Faraone, Stephen V. (1)
- Farde, Lars (1)
- Fasolo, Francesca (1)
- Fatouros-Bergman, Helena (1)
- Fernndez, Guillen (1)
- Fisher, Simon E. (1)
- Flyckt, Lena (1)
- Forster, Katharina (1)
- Foxe, John J. (1)
- Francks, Clyde (1)
- Franke, Barbara (1)
- Fuentes-Claramonte, Paola (1)
- Fullerton, Janice M. (1)
- Garavan, Hugh (1)
- Garcia, Danielle do Santos (1)
- Glahn, David C. (1)
- Glukha, Nadiya (1)
- Gotlib, Ian H. (1)
- Goudriaan, Anna E. (1)
- Grabe, Hans Jörgen (1)
- Groenewold, Nynke A. (1)
- Grotegerd, Dominik (1)
- Gruber, Oliver (1)
- Guadalupe, Tulio (1)
- Gurholt, Tiril (1)
- Haavik, Jan (1)
- Hahn, Tim (1)
- Hansell, Narelle K. (1)
- Harris, Mathew A. (1)
- Hartman, Catharina (1)
- Hedberg, Mikael (1)
- Hernandez, Maria del Carmen Valdes (1)
- Heslenfeld, Dirk (1)
- Hester, Robert (1)
- Hibar, Derrek Paul (1)
- Ho, Beng-Choon (1)
- Ho, Tiffany C. (1)
- Hoekstra, Pieter J. (1)
- Hoogman, Martine (1)
- Hovik, Marie F. (1)
- Howells, Fleur M. (1)
- Hugdahl, Kenneth (1)
- Hultgren, Rebecka (1)
- Huyser, Chaim (1)
- Ingvar, Martind (1)
- Irwin, Lourdes (1)
- Ishikawa, Akari (1)
- Jahanshad, Neda (1)
- James, Anthony (1)
- Jean-Paul, Fouche (1)
- Jernigan, Terry L. (1)
- Jönsson, Erik G. (1)
- Kahler, Claas (1)
- Kaleda, Vasily (1)
- Kelly, Clare (1)
- Kerich, Michael (1)
- Keshavan, Matcheri S (1)
- Khadka, Sabin (1)
- Kircher, Tilo (1)
- Knappich, Christoph Magnus (1)
- Kohls, Gregor (1)
- Kong, Xiang-Zhen (1)
- Konrad, Kerstin (1)
- Korucuoglu, Ozlem (1)
- Krug, Axel (1)
- Krämer, Bernd (1)
- Kwon, Jun Soo (1)
- Lambregts-Rommelse, Nanda (1)
- Landén, Mikael (1)
- Lebedeva, Irina (1)
- Lenroot, Rhoshel (1)
- Lesch, Klaus-Peter J. (1)
- Li, Qinqin (1)
- Li, Zhaolong (1)
- Lim, Kelvin O. (1)
- Liu, Jia (1)
- Lochner, Christine (1)
- London, Edythe D. (1)
- Lonning, Vera (1)
- Lorenzetti, Valentina (1)
- Luciano, Michelle (1)
- Luijten, Maartje (1)
- Lundervold, Astri J. (1)
- Lázaro, Luisa (1)
- MacMaster, Frank P. (1)
- Mackey, Scott (1)
- Maingault, Sophie (1)
- Malmqvist, Anna (1)
- Malpas, Charles B. (1)
- Malt, Ulrik F. (1)
- Maniega, Susana Munoz (1)
- Martin-Santos, Rocio (1)
- Mataix-Cols, David (1)
- Mathias, Samuel R. (1)
- Mayer, Andrew R. (1)
- Mazoyer, Bernard (1)
- McCarthy, Hazel (1)
- McDonald, Colm (1)
- McLellan, Quinn (1)
- McMahon, Katie L. (1)
- McPhilemy, Genevieve (1)
- Meer, Dennis van der (1)
- Mitchell, Philip B. (1)
- Momenan, Reza (1)
- Morales, Angelica M. (1)
- Moreira, José Carlos Vasques (1)
- Mueller, Bryon A. (1)
- Narayanaswamy, Janardhanan C. (1)
- Nerland, Stener (1)
- Nestor, Liam (1)
- Nigg, Joel T. (1)
- Nordvik, Jan-Egil (1)
- Novotny, Stephanie (1)
- Oberwelland, Eileen (1)
- Oosterlaan, Jaap (1)
- Oranje, Bob (1)
- Orhan, Funda (1)
- Orr, Catherine (1)
- Overs, Bronwyn (1)
- O’Gorman, Ruth L. (1)
- Paloschi, Valentina (1)
- Pauli, Paul (1)
- Paulus, Martin (1)
- Piehl, Fredrik (1)
- Plessen, Kerstin (1)
- Polier, Georg von (1)
- Pomarol-Clotet, Edith (1)
- Qiu, Jiang (1)
- Radua, Joaquim (1)
- Ramos-Quiroga, J. Antoni (1)
- Reddy, Y.C. Janardhan (1)
- Reif, Andreas (1)
- Ritzer, Julia (1)
- Roberts, Gloria (1)
- Rosa, Pedro (1)
- Roy, Joy (1)
- Rubia, Katya (1)
- Sacchet, Matthew D. (1)
- Sachdev, Perminder S. (1)
- Sachs, Nadja (1)
- Salvador, Raymond (1)
- Saud, Alhusaini (1)
- Schmaal, Lianne (1)
- Schweren, Lisanne (1)
- Schwieler, Lilly (1)
- Seidman, Larry J. (1)
- Seitz, Jochen (1)
- Serpa, Mauricio Henriques (1)
- Shaw, Philip (1)
- Shumskaya, Elena (1)
- Silk, Timothy J. (1)
- Simmons, Alan N. (1)
- Simulionyte, Egle (1)
- Sinha, Rajita (1)
- Sjoerds, Zsuzsika (1)
- Smelror, Runar Elle (1)
- Soliva, Joan Carlos (1)
- Solowij, Nadia (1)
- Sponheim, Scott R. (1)
- Stein, Dan J. (1)
- Stein, Elliot A. (1)
- Stevens, Michael (1)
- Strike, Lachlan T. (1)
- Sudre, Gustavo (1)
- Sui, Jing (1)
- Tamm, Leanne (1)
- Temmingh, Hendrik S. (1)
- Thoma, Robert J. (1)
- Thompson, Paul M. (1)
- Tomyshev, Alexander S. (1)
- Tronchin, Giulia (1)
- Turner, Jessica A. (1)
- Tzourio-Mazoyer, Nathalie (1)
- Uhlmann, Anne (1)
- Vance, Alasdair (1)
- Veer, Ilya M. (1)
- Veltman, Dick J. (1)
- Venkatasubramanian, Ganesan (1)
- Victorsson, Pauliina (1)
- Vilarroya, Oscar (1)
- Vives-Gilabert, Yolanda (1)
- Voineskos, Aristotle N. (1)
- Vuletic, Daniella (1)
- Völzke, Henry (1)
- Walitza, Susanne (1)
- Walter, Henrik (1)
- Walton, Esther (1)
- Wardlaw, Joanna M. (1)
- Wen, Wei (1)
- Westlye, Lars T. (1)
- Whelan, Christopher D. (1)
- White, Tonya (1)
- Wiers, Reinout W. (1)
- Winski, Greg (1)
- Winter, Hanna (1)
- Wittfeld, Katharina (1)
- Wright, Margaret J. (1)
- Wu, Zhiyuan (1)
- Yang, Tony T. (1)
- Yasuda, Clarissa L. (1)
- Yoncheva, Yuliya (1)
- Yucel, Murat (1)
- Yun, Je-Yeon (1)
- Zanetti, Marcus Vinicius (1)
- Zeeuw, Patrick de (1)
- Zhen, Zonglei (1)
- Zhu, Xing-xing (1)
- Ziegler, Georg Christoph (1)
- Zierhut, Kathrin (1)
- Zwiers, Marcel P. (1)
- de Bruttopilo, Sara Ambrosino (1)
- van Erp, Theo G.M. (1)
- van Holst, Ruth J. (1)
- van den Heuvel, Odile (1)
Language
- English (3)
Has Fulltext
- yes (3)
Is part of the Bibliography
- no (3)
Keywords
- ATM (1)
- Ageing (1)
- Endothelial cells (1)
- MT: Non-coding RNAs (1)
- Non-coding RNA (1)
- abdominal aortic aneurysm (1)
- apoptosis (1)
- biomarker (1)
- circular RNA (1)
- doxorubicin (1)
Institute
- Medizin (3)
Highlights
• Endothelial ageing contributes significantly to atherosclerosis.
• Non-coding RNAs are gaining interest as regulators of vascular biology.
• Several microRNAs regulate endothelial cell ageing.
• Multiple lncRNAs play a role in endothelial cell ageing.
Abstract
Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA like microRNAs and long non-coding RNAs are known to play an important role in endothelial function and are implicated in the disease progression. Here, we summarize several microRNAs and long non-coding RNAs that are known to have an altered expression with endothelial aging and discuss their role in endothelial cell function and senescence. These processes contribute to aging-induced atherosclerosis development and by targeting the non-coding RNAs controlling endothelial cell function and senescence, atherosclerosis can potentially be attenuated.
Fasolo, Francesca ; Winski, Greg ; Li, Zhaolong ; Wu, Zhiyuan ; Winter, Hanna ; Ritzer, Julia ; Glukha, Nadiya ; Roy, Joy ; Hultgren, Rebecka ; Pauli, Jessica ; Busch, Albert Franz Jakob ; Sachs, Nadja ; Knappich, Christoph Magnus ; Eckstein, Hans-Henning ; Boon, Reinier ; Paloschi, Valentina ; Mägdefessel, Lars
An abdominal aortic aneurysm (AAA) is a pathological widening of the aortic wall characterized by loss of smooth muscle cells (SMCs), extracellular matrix degradation, and local inflammation. This condition is often asymptomatic until rupture occurs, leading to high morbidity and mortality rates. Diagnosis is mostly accidental and the only currently available treatment option remains surgical intervention. Circular RNAs (circRNAs) represent a novel class of regulatory non-coding RNAs that originate from backsplicing. Their highly stable loop structure, combined with a remarkable enrichment in body fluids, make circRNAs promising disease biomarkers. We investigated the contribution of circRNAs to AAA pathogenesis and their potential application to improve AAA diagnostics. Gene expression analysis revealed the presence of deregulated circular transcripts stemming from AAA-relevant gene loci. Among these, the circRNA to the Ataxia Telangiectasia Mutated gene (cATM) was upregulated in human AAA specimens, in AAA-derived SMCs, and serum samples collected from aneurysm patients. In primary aortic SMCs, cATM increased upon angiotensin II and doxorubicin stimulation, while its silencing triggered apoptosis. Higher cATM levels made AAA-derived SMCs less vulnerable to oxidative stress, compared with control SMCs. These data suggest that cATM contributes to elicit an adaptive oxidative-stress response in SMCs and provides a reliable AAA disease signature.
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
(2017)
Kong, Xiang-Zhen ; Mathias, Samuel R. ; Guadalupe, Tulio ; Abé, Christoph ; Agartz, Ingrid ; Akudjedu, Theophilus N. ; Andre, Aleman ; Saud, Alhusaini ; Allen, Nicholas B. ; Ames, David ; Andreassen, Ole A. ; Arias Vásquez, Alejandro ; Armstrong, Nicola J. ; Bergo, Felipe ; Bastin, Mark E. ; Batalla, Albert ; Bauer, Jochen ; Baune, Bernhard T. ; Baur, Ramona ; Biederman, Joseph ; Blaine, Sara K. ; Boedhoe, Premika ; Bøen, Erlend ; Bose, Anushree ; Bralten, Janita ; Brandeis, Daniel ; Brem, Silvia ; Brodaty, Henry ; Bröhl, Henrieke ; Brooks, Samantha J. ; Buitelaar, Jan K. ; Bürger, Christian ; Bülow, Robin ; Calhoun, Vince D. ; Calvo, Anna ; Canales-Rodrı́guez, Erick Jorge ; Canive, Jose M. ; Cannon, Dara M. ; Caparelli, Elisabeth C. ; Castellanos, Francisco X. ; Cavalleri, Gianpiero L. ; Cendes, Fernando ; Chaim-Avancini, Tiffany Moukbel ; Chantiluke, Kaylita ; Chen, Qun-lin ; Chen, Xiayu ; Cheng, Yuqi ; Christakou, Anastasia ; Clark, Vincent P. ; Coghill, David ; Connolly, Colm G. ; Conzelmann, Annette ; Cόrdova-Palomera, Aldo ; Cousijn, Janna ; Crow, Tim ; Cubillo, Ana ; Dannlowski, Udo ; de Bruttopilo, Sara Ambrosino ; Zeeuw, Patrick de ; Deary, Ian J. ; Delanty, Norman ; Demeter, Damion V. ; Di Martino, Adriana ; Dickie, Erin W ; Dietsche, Bruno ; Doan, N. Trung ; Doherty, Colin P. ; Doyle, Alysa ; Durston, Sarah ; Earl, Eric ; Ehrlich, Stefan ; Ekman, Carl Johan ; Elvsåshagen, Torbjørn ; Epstein, Jeffery N. ; Fair, Damien A. ; Faraone, Stephen V. ; Fatouros-Bergman, Helena ; Fernndez, Guillen ; Busatto Filho, Geraldo ; Flyckt, Lena ; Forster, Katharina ; Jean-Paul, Fouche ; Foxe, John J. ; Fuentes-Claramonte, Paola ; Fullerton, Janice M. ; Garavan, Hugh ; Garcia, Danielle do Santos ; Gotlib, Ian H. ; Goudriaan, Anna E. ; Grabe, Hans Jörgen ; Groenewold, Nynke A. ; Grotegerd, Dominik ; Gruber, Oliver ; Gurholt, Tiril ; Haavik, Jan ; Hahn, Tim ; Hansell, Narelle K. ; Harris, Mathew A. ; Hartman, Catharina ; Hernandez, Maria del Carmen Valdes ; Heslenfeld, Dirk ; Hester, Robert ; Hibar, Derrek Paul ; Ho, Beng-Choon ; Ho, Tiffany C. ; Hoekstra, Pieter J. ; van Holst, Ruth J. ; Hoogman, Martine ; Hovik, Marie F. ; Howells, Fleur M. ; Hugdahl, Kenneth ; Huyser, Chaim ; Ingvar, Martind ; Irwin, Lourdes ; Ishikawa, Akari ; James, Anthony ; Jahanshad, Neda ; Jernigan, Terry L. ; Jönsson, Erik G. ; Kahler, Claas ; Kaleda, Vasily ; Kelly, Clare ; Kerich, Michael ; Keshavan, Matcheri S ; Khadka, Sabin ; Kircher, Tilo ; Kohls, Gregor ; Konrad, Kerstin ; Korucuoglu, Ozlem ; Krämer, Bernd ; Krug, Axel ; Kwon, Jun Soo ; Lambregts-Rommelse, Nanda ; Landén, Mikael ; Lázaro, Luisa ; Lebedeva, Irina ; Lenroot, Rhoshel ; Lesch, Klaus-Peter J. ; Li, Qinqin ; Lim, Kelvin O. ; Liu, Jia ; Lochner, Christine ; London, Edythe D. ; Lonning, Vera ; Lorenzetti, Valentina ; Luciano, Michelle ; Luijten, Maartje ; Lundervold, Astri J. ; Mackey, Scott ; MacMaster, Frank P. ; Maingault, Sophie ; Malpas, Charles B. ; Malt, Ulrik F. ; Mataix-Cols, David ; Martin-Santos, Rocio ; Mayer, Andrew R. ; McCarthy, Hazel ; Mitchell, Philip B. ; Mueller, Bryon A. ; Maniega, Susana Munoz ; Mazoyer, Bernard ; McDonald, Colm ; McLellan, Quinn ; McMahon, Katie L. ; McPhilemy, Genevieve ; Momenan, Reza ; Morales, Angelica M. ; Narayanaswamy, Janardhanan C. ; Moreira, José Carlos Vasques ; Nerland, Stener ; Nestor, Liam ; Nigg, Joel T. ; Nordvik, Jan-Egil ; Novotny, Stephanie ; Oberwelland, Eileen ; O’Gorman, Ruth L. ; Oosterlaan, Jaap ; Oranje, Bob ; Orr, Catherine ; Overs, Bronwyn ; Pauli, Paul ; Paulus, Martin ; Plessen, Kerstin ; Polier, Georg von ; Pomarol-Clotet, Edith ; Qiu, Jiang ; Radua, Joaquim ; Ramos-Quiroga, J. Antoni ; Reddy, Y.C. Janardhan ; Reif, Andreas ; Roberts, Gloria ; Rosa, Pedro ; Rubia, Katya ; Sacchet, Matthew D. ; Sachdev, Perminder S. ; Salvador, Raymond ; Schmaal, Lianne ; Schweren, Lisanne ; Seidman, Larry J. ; Seitz, Jochen ; Serpa, Mauricio Henriques ; Shaw, Philip ; Shumskaya, Elena ; Silk, Timothy J. ; Simmons, Alan N. ; Simulionyte, Egle ; Sinha, Rajita ; Sjoerds, Zsuzsika ; Smelror, Runar Elle ; Soliva, Joan Carlos ; Solowij, Nadia ; Sponheim, Scott R. ; Stein, Dan J. ; Stein, Elliot A. ; Stevens, Michael ; Strike, Lachlan T. ; Sudre, Gustavo ; Sui, Jing ; Tamm, Leanne ; Temmingh, Hendrik S. ; Thoma, Robert J. ; Tomyshev, Alexander S. ; Tronchin, Giulia ; Turner, Jessica A. ; Uhlmann, Anne ; van Erp, Theo G.M. ; van den Heuvel, Odile ; Meer, Dennis van der ; Eijk, Liza van ; Vance, Alasdair ; Veer, Ilya M. ; Veltman, Dick J. ; Venkatasubramanian, Ganesan ; Vilarroya, Oscar ; Vives-Gilabert, Yolanda ; Voineskos, Aristotle N. ; Völzke, Henry ; Vuletic, Daniella ; Walitza, Susanne ; Walter, Henrik ; Walton, Esther ; Wardlaw, Joanna M. ; Wen, Wei ; Westlye, Lars T. ; Whelan, Christopher D. ; White, Tonya ; Wiers, Reinout W. ; Wright, Margaret J. ; Wittfeld, Katharina ; Yang, Tony T. ; Yasuda, Clarissa L. ; Yoncheva, Yuliya ; Yucel, Murat ; Yun, Je-Yeon ; Zanetti, Marcus Vinicius ; Zhen, Zonglei ; Zhu, Xing-xing ; Ziegler, Georg Christoph ; Zierhut, Kathrin ; De Zubicaray, Greig ; Zwiers, Marcel P. ; Glahn, David C. ; Franke, Barbara ; Crivello, Fabrice ; Tzourio-Mazoyer, Nathalie ; Fisher, Simon E. ; Thompson, Paul M. ; Francks, Clyde ; Farde, Lars ; Engberg, Goran ; Erhardt, Sophie ; Cervenka, Simon ; Schwieler, Lilly ; Piehl, Fredrik ; Collste, Karin ; Victorsson, Pauliina ; Malmqvist, Anna ; Hedberg, Mikael ; Orhan, Funda
- 1 to 3