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Background We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angioedema: a current state-of-the-art review: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Objective To update the International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema (circa 2010). Methods The Canadian Hereditary Angioedema Network (CHAEN)/Reseau Canadien d'angioedeme hereditaire (RCAH) (www.haecanada.com) and cosponsors University of Calgary and the Canadian Society of Allergy and Clinical Immunology (with an unrestricted educational grant from CSL Behring) held our third Conference May 15th to 16th, 2010 in Toronto Canada to update our consensus approach. The Consensus document was reviewed at the meeting and then circulated for review. Results This manuscript is the 2010 International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema that resulted from that conference. Conclusions Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches including quality of life and cost benefit analyses, followed by large head-to-head clinical trials and then evidence-based guidelines and standards for HAE disease management.
Nuclear transport models are important tools for interpretation of many heavy-ion experiments and are essential in efforts to probe the nuclear equation of state. In order to fulfill these roles, the model predictions should at least agree with observed single-particle-inclusive momentum spectra; however, this agreement has recently been questioned. The present work compares the Vlasov-Uehling-Uhlenbeck model to data for mass-symmetric systems ranging from 12C+12C to 139La+139La, and we find good agreement within experimental uncertainties at 0.4A and 0.8A GeV. For currently available data, these uncertainties are too large to permit effective nucleon-nucleon scattering cross sections in the nuclear medium to be extracted at a useful level of precision.