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Verschiedene Senfzubereitungen werden mit Formaldehydlösung (0,2 %ig) bezüglich der Austreibungswirkung auf Regenwürmer verglichen. Die Untersuchungen bestätigen die grundsätzliche Eignung einer Senfsuspension als Austreibungsmittel für Regenwürmer. Anecische Regenwürmer werden von Senfsuspension und Formalin gut ausgetrieben. Von den endogäischen Regenwürmern bleiben selbst nach Formalinanwendung noch mehr als 50 % im Boden. Für eine vollständige Regenwurmerfassung ist deshalb die Kombination von Austreibung mit Senf und Handauslese unerlässlich. Formalin ist wegen seiner ökotoxischen und humantoxischen Effekte als Austreibungsmittel für Regenwürmer abzulehnen.
While patients with chronic hepatitis C virus (HCV) infection are treated in order to prevent liver-related morbidity and mortality, we rely on sustained virological response (SVR) as a virological biomarker to evaluate treatment efficacy in both clinical practice as well as in drug development. However, conclusive evidence for the clinical benefit of antiviral therapy or validity of SVR as surrogate marker, as derived from trials randomizing patients to a treatment or control arm, is lacking. In fact, the Hepatitis C Antiviral Long-term Treatment Against Cirrhosis (HALT-C) trial recently showed an increased mortality rate among interferon-treated patients compared to untreated controls. Consequently, the recommendation to treat patients with chronic HCV infection was challenged.
Here, we argue that the possible harmful effect of long-term low-dose pegylated interferon mono therapy, as was observed in the HALT-C trial cohort, cannot be extrapolated to potentially curative short-term treatment regimens. Furthermore, we discuss SVR as a surrogate biomarker, based on numerous studies which indicated an association between SVR and improvements in health-related quality of life, hepatic inflammation and fibrosis, and portal pressure as well as a reduced risk for hepatocellular carcinoma (HCC), liver failure and mortality.