Refine
Author
- Reif, Andreas (5)
- Ebner-Priemer, Ulrich (4)
- Koch, Elena (4)
- Koch, Elias Andreas Thomas (4)
- Bechstein, Wolf Otto (3)
- Freitag, Christine M. (3)
- Geburtig-Chiocchetti, Andreas (3)
- Koch, Christine (3)
- Ortega, Francisco B. (3)
- Schnitzbauer, Andreas (3)
- Trojan, Jörg (3)
- Waidmann, Oliver (3)
- Zeuzem, Stefan (3)
- Ackermann, Jörg (2)
- Asherson, Philip (2)
- Berrevoet, Frederik (2)
- Buitelaar, Jan K. (2)
- Büchner, Hubert (2)
- Cichon, Sven (2)
- Dousset, Bertrand (2)
- Fortelny, René H. (2)
- Gossetti, Francesco (2)
- Grimm, Oliver (2)
- Henrich, Dirk (2)
- Jeekel, Johannes (2)
- Jørgensen, Lars Nannestad (2)
- Koch, Andreas (2)
- Koch, Benjamin Florian (2)
- Koch, Ina (2)
- Kuntsi, Jonna (2)
- Köckerling, Ferdinand (2)
- Lange, Johan F. (2)
- Leiblein, Maximilian (2)
- Marzi, Ingo (2)
- Mayer, Jutta (2)
- Medda, Juliane (2)
- Miserez, Marc (2)
- Muntaner-Mas, Adrià (2)
- Nau, Christoph (2)
- Piessen, Guillaume (2)
- Ramos-Quiroga, Josep Antoni (2)
- Rooijen, Mathilde van (2)
- Schaible, Alexander (2)
- Schrecker, Christopher (2)
- Tetteroo, Geert W. M. (2)
- Tollens, Tim (2)
- Vries Reilingh, Tammo S. de (2)
- Westreenen, Henderik Leendert van (2)
- Windsor, Alastair C. J. (2)
- Woeste, Guido (2)
- Zacharowski, Kai (2)
- Adam, Elisabeth (1)
- Adolfsson, Rolf (1)
- Adorjan, Kristina (1)
- Agerbo, Esben (1)
- Albani, Diego (1)
- Albrecht, Moritz Hans Ernst (1)
- Alda, Martin (1)
- Alemany, Silvia (1)
- Alfredsson, Lars (1)
- Alliey-Rodriguez, Ney (1)
- Almeida, Francisca F. (1)
- Als, Thomas D. (1)
- Alt, Jürgen (1)
- Andlauer, Till F. M. (1)
- Andreassen, Ole A. (1)
- Antoniou, Anastasia (1)
- Ask, Helga (1)
- Backlund, Lena (1)
- Baer, Patrick C. (1)
- Bankov, Katrin (1)
- Bass, Nicholas (1)
- Basten, Lajos Maximilian (1)
- Bauer, Michael (1)
- Baumgarten, Georg (1)
- Baune, Bernhard T. (1)
- Beins, Eva C. (1)
- Bellina, Mariano (1)
- Bellivier, Frank (1)
- Belz, Gabrielle T. (1)
- Bendl, Jaroslav (1)
- Bengesser, Susanne (1)
- Berger, Marc (1)
- Bergsma, Douwe (1)
- Berking, Carola (1)
- Bernatz, Simon (1)
- Berrettini, Wade H. (1)
- Bette, Theresa (1)
- Bickenbach, Johannes (1)
- Biergans, Stephanie (1)
- Biernacka, Joanna M. (1)
- Bigdeli, Tim B. (1)
- Biscaldi, Monica (1)
- Bischoff, Helge (1)
- Bodelle, Boris (1)
- Boehnke, Michael (1)
- Boks, Marco P. (1)
- Boltz, Toni (1)
- Bosch, Rosa (1)
- Brand, Hannah Antonia (1)
- Brandenburger, Timo (1)
- Breen, Gerome (1)
- Brenner, Thorsten (1)
- Brum, Murielle (1)
- Brumpton, Ben M. (1)
- Brunkhorst-Kanaan, Nathalie (1)
- Bucher, Andreas (1)
- Budde, Monika (1)
- Bybjerg-Grauholm, Jonas (1)
- Byerley, William (1)
- Børglum, Anders D. (1)
- Børte, Sigrid (1)
- Cabana-Domínguez, Judit (1)
- Cadenas-Sanchez, Cristina (1)
- Cairns, Murray J. (1)
- Carpiniello, Bernardo (1)
- Carr, Vaughan J. (1)
- Casas, Miquel (1)
- Cathomas, Richard (1)
- Catts, Stanley (1)
- Cervantes, Pablo (1)
- Chatzinakos, Chris (1)
- Chen, Hsi-Chung (1)
- Chun, Felix (1)
- Clarence, Tereza (1)
- Clarke, Toni-Kim (1)
- Claus, Isabelle (1)
- Coleman, Jonathan R. I. (1)
- Colla, Michael (1)
- Coombes, Brandon (1)
- Corfield, Elizabeth C. (1)
- Corvin, Aiden (1)
- Craddock, Nicholas (1)
- Cruceanu, Cristiana (1)
- Cuellar-Barboza, Alfredo (1)
- Czerski, Piotr M. (1)
- Dafnas, Konstantinos (1)
- Dale, Anders M. (1)
- Dalkner, Nina (1)
- Dannlowski, Udo (1)
- David, Friederike S. (1)
- DePaulo, J. Raymond (1)
- Degenhardt, Franziska (1)
- Di Florio, Arianna (1)
- Dikeos, Dimitris (1)
- Dippel, Edgar (1)
- Djurovic, Srdjan (1)
- Doener, Fatma (1)
- Drange, Ole Kristian (1)
- Duketis, Eftichia (1)
- Döring, Claudia (1)
- Edel, Andreas (1)
- Edenberg, Howard J. (1)
- Ehrentraut, Heidi (1)
- Enghard, Philipp (1)
- Escott-Price, Valentina (1)
- Etain, Bruno (1)
- Fanous, Ayman H. (1)
- Farmand, Samira (1)
- Faure, Fabrice (1)
- Fellendorf, Frederike T. (1)
- Ferentinos, Panagiotis (1)
- Ferrier, I. Nicol (1)
- Fichtner, Falk (1)
- Filmann, Natalie (1)
- Firth, Matthew (1)
- Forstner, Andreas J. (1)
- Forty, Liz (1)
- Fotin-Mleczek, Mariola (1)
- Frank, Josef (1)
- Frei, Oleksandr (1)
- Freimer, Nelson B. (1)
- Friede, Miriam Elisabeth (1)
- Frye, Mark (1)
- Früh, Martin (1)
- Fuhrmann, Dominik Christian (1)
- Fullard, John F. (1)
- Fullerton, Janice M. (1)
- Galluso, Justine (1)
- Garnham, Julie (1)
- Gawlik, Micha (1)
- Geißler, Michael (1)
- Gershon, Elliot S. (1)
- Gesierich, Anja Heike (1)
- Geßner, Alec (1)
- Giannattasio, Ariane (1)
- Gilot, Bryant (1)
- Giurgiu, Marco (1)
- Gizer, Ian R. (1)
- Gnad-Vogt, Ulrike (1)
- Goes, Fernando S. (1)
- Gordon, Scott D. (1)
- Gordon-Smith, Katherine (1)
- Green, Melissa J. (1)
- Greenwood, Tiffany A. (1)
- Griesinger, Frank (1)
- Grigoroiu-Serbanescu, Maria (1)
- Grohé, Christian (1)
- Grove, Jakob (1)
- Grützkau, Andreas (1)
- Gutzmer, Ralf (1)
- Guzman-Parra, José (1)
- Görlich, Nina (1)
- Ha, Tae Hyon (1)
- Haferkamp, Sebastian (1)
- Hahn, Tim (1)
- Hammerstingl, Renate Maria (1)
- Haraldsson, Magnus (1)
- Harder, Arvid (1)
- Haring, Robin (1)
- Harter, Patrick Nikolaus (1)
- Haslinger, Denise (1)
- Hassel, Jessica C. (1)
- Hauser, Joanna (1)
- Hautzinger, Martin (1)
- Havdahl, Alexandra (1)
- Hees, Katharina (1)
- Heilbronner, Urs (1)
- Hellgren, Dennis (1)
- Henskens, Frans A. (1)
- Heppt, Markus V. (1)
- Herms, Stefan (1)
- Herold, Marco (1)
- Herrmann, Eva (1)
- Herrmann, Johannes (1)
- Hickie, Ian B. (1)
- Hilbe, Wolfgang (1)
- Hipp, Madeleine M. (1)
- Hjerling-Leffler, Jens (1)
- Hoeft, Andreas (1)
- Hoffmann, Per (1)
- Hofmann, Pascal (1)
- Hohberger, Bettina (1)
- Holmans, Peter A. (1)
- Hong, Henoch Sangjoon (1)
- Hougaard, David M. (1)
- Hoyer, Jürgen (1)
- Huang, Ming-Chyi (1)
- Huntington, Nicholas D. (1)
- Husman, Gabriele (1)
- Hveem, Kristian (1)
- Häberle, Helene (1)
- Ibáñez, Pol (1)
- Ikeda, Masashi (1)
- Iwata, Nakao (1)
- Jairam, An (1)
- Jamain, Stéphane (1)
- Johnson, Jessica S. (1)
- Jones, Ian (1)
- Jones, Lisa A. (1)
- Jonsson, Lina (1)
- Jungwirth, Bettina (1)
- Kahn, René S. (1)
- Kalensee, Franziska (1)
- Kallen, Karl-Josef (1)
- Kalman, Janos L. (1)
- Kaltenbach, Benjamin (1)
- Kamatani, Yoichiro (1)
- Kay Yang, Jessica Mei (1)
- Kelsoe, John R. (1)
- Kennedy, James L. (1)
- Kieser, Meinhard (1)
- Kim, Euitae (1)
- Kim, Jaeyoung (1)
- Kindgen-Milles, Detlef (1)
- Kircher, Tilo (1)
- Kirov, George (1)
- Kische, Hanna (1)
- Kittel-Schneider, Sarah (1)
- Klauck, Sabine M. (1)
- Klinkhardt, Ute (1)
- Klotsche, Jens (1)
- Knorr, Harald (1)
- Knowles, James A. (1)
- Knüfermann, Pascal (1)
- Koch, Alexander (1)
- Koch, Christian (1)
- Koch, Elise (1)
- Koch, Joachim (1)
- Koch, Sven D. (1)
- Koch, Thea (1)
- Koch-Gromus, Uwe (1)
- Kogevinas, Manolis (1)
- Kohlbacher, Oliver (1)
- Koromina, Maria (1)
- Kranz, Thorsten M. (1)
- Krebs, Kristi (1)
- Kreuzberg-Brenner, Nicole (1)
- Kroese, Leonard F. (1)
- Kueh, Andrew J. (1)
- Kuo, Po-Hsiu (1)
- Kushner, Steven A. (1)
- Kähler, Katharina C. (1)
- Köllermann, Jens (1)
- Köppen, Michael (1)
- Lahmer, Tobias (1)
- Landén, Mikael (1)
- Langhans, Valerie (1)
- Lavebratt, Catharina (1)
- Lawrence, Jacob (1)
- Lay, Michael (1)
- Leber, Markus (1)
- Leboyer, Marion (1)
- Lederer, Simone (1)
- Lee, Heon-Jeong (1)
- Lehnert, Hendrik (1)
- Leiter-Stöppke, Ulrike (1)
- Li, Qingqin S. (1)
- Liao, Calwing (1)
- Liao, Yang (1)
- Lin, Keng-Han (1)
- Lind, Penelope A. (1)
- Lissowska, Jolanta (1)
- Lochner, Christine (1)
- Loquai, Carmen (1)
- Loughland, Carmel (1)
- Lucae, Susanne (1)
- Lundberg, Martin (1)
- Luong, Kylie (1)
- Luykx, Jurjen J. (1)
- MacIntyre, Donald J. (1)
- Magunia, Harry (1)
- Maier, Wolfgang (1)
- Maihofer, Adam X. (1)
- Malaspina, Dolores (1)
- Malek, Nisar Peter (1)
- Manchia, Mirko (1)
- Mandel, Philipp (1)
- Maratou, Eirini (1)
- Martin, Nicholas G. (1)
- Martinez-Nicolas, Antonio (1)
- Martinsson, Lina (1)
- Marx, Gernot (1)
- Marçais, Antoine (1)
- Mathews, Carol A. (1)
- Mattheisen, Manuel (1)
- Matura, Silke (1)
- Mayoral, Fermin (1)
- McElroy, Susan L. (1)
- McGregor, Nathaniel W. (1)
- McGrouther, Caroline C. (1)
- McInnis, Melvin G. (1)
- McIntosh, Andrew M. (1)
- McKay, James D. (1)
- McMahon, Francis J. (1)
- McQuillin, Andrew (1)
- Medeiros, Helena (1)
- Medland, Sarah E. (1)
- Meier, Friedegund (1)
- Meiser, Andreas (1)
- Meissner, Markus (1)
- Melle, Ingrid (1)
- Mercier, Francois E. (1)
- Mersmann, Jan (1)
- Meybohm, Patrick (1)
- Meyer, Rainer (1)
- Meyer-Lindenberg, Andreas (1)
- Migueles, Jairo H. (1)
- Milani, Lili (1)
- Millischer, Vincent (1)
- Mirakaj, Valbona (1)
- Mitchell, Brittany L. (1)
- Mitchell, Philip B. (1)
- Mohr, Peter (1)
- Molina-Garcia, Pablo (1)
- Morken, Gunnar (1)
- Morris, Derek W. (1)
- Mors, Ole (1)
- Mortensen, Preben Bo (1)
- Moutsatsou, Paraskevi (1)
- Mullins, Niamh (1)
- Muth, Anke (1)
- Myers, Richard M. (1)
- Myung, Woojae (1)
- März, Winfried (1)
- Mörer, Onnen (1)
- Mühleisen, Thomas W. (1)
- Müller-Myhsok, Bertram (1)
- Narni-Mancinelli, Emilie (1)
- Nau, Carla (1)
- Neale, Benjamin M. (1)
- Nievergelt, Caroline M. (1)
- Nohe, Boris (1)
- Nordentoft, Merete (1)
- Nurnberger, John I. (1)
- Nöthen, Markus M. (1)
- Nöthen, Markus Maria (1)
- Oedegaard, Ketil J. (1)
- Olsen, Catherine M. (1)
- Olsson, Tomas (1)
- Ophoff, Roel A. (1)
- Owen, Michael J. (1)
- O’Connell, Kevin S. (1)
- O’Donovan, Claire (1)
- O’Donovan, Michael C. (1)
- Paciga, Sara A. (1)
- Palacio Sanchez, Judit (1)
- Paliege, Alexander (1)
- Pall, Georg (1)
- Panagiotaropoulou, Georgia (1)
- Pantelis, Christos (1)
- Papachristofilou, Alexandros (1)
- Papiol, Sergi (1)
- Pardiñas, Antonio F. (1)
- Park, Hye Youn (1)
- Parker, Nadine (1)
- Pato, Carlos N. (1)
- Pato, Michele T. (1)
- Patrinos, George P. (1)
- Pawlak, Joanna M. (1)
- Pawley, Adam D. (1)
- Pedersen, Carsten Bøcker (1)
- Perry, Amy (1)
- Petzold, Anne (1)
- Pfennig, Andrea (1)
- Pföhler, Claudia Ursula (1)
- Pieper, Lars (1)
- Pisanu, Claudia (1)
- Pittrow, David (1)
- Pless, Miklos (1)
- Posch, Matthias (1)
- Potash, James B. (1)
- Prätsch, Florian (1)
- Putensen, Christian (1)
- Quested, Digby (1)
- Rahimi, Farnaz (1)
- Rahmel, Tim (1)
- Rais, Bushra (1)
- Ramos-Quiroga, J. Antoni (1)
- Rangan, Aaditya V. (1)
- Rapaport, Mark H. (1)
- Regeer, Eline J. (1)
- Reichert, Markus (1)
- Reinhard, Iris (1)
- Reininghaus, Eva Z. (1)
- Reinke, Petra (1)
- Ribasés, Marta (1)
- Rice, John P. (1)
- Rietschel, Marcella (1)
- Ripke, Stephan (1)
- Rivera, Margarita (1)
- Rommel, Anna-Sophie (1)
- Rommelse, Nanda (1)
- Rosbach, Nicolas (1)
- Rosenberger, Peter (1)
- Rouleau, Guy A. (1)
- Roussos, Panos (1)
- Rowlands, Alex V. (1)
- Ruf, Alea (1)
- Ruiter, Saskia de (1)
- Sachse, Michael (1)
- Saito, Takeo (1)
- Scadden, David T. (1)
- Schachtner, Thomas (1)
- Schadendorf, Dirk (1)
- Schall, Ulrich (1)
- Schalling, Martin (1)
- Scheel, Birgit (1)
- Scheer, Christian S. (1)
- Schell, Beatrice (1)
- Schiefenhövel, Fridtjof (1)
- Schlaak, Max Simon (1)
- Schleicher, Ulrike (1)
- Schneider, Gerhard (1)
- Schneider, Wolfgang (1)
- Schofield, Peter R. (1)
- Schröder, Andreas (1)
- Schröder, Katrin (1)
- Schubert, Ralf (1)
- Schuler-Thurner, Beatrice (1)
- Schulte, Eva C. (1)
- Schulte-Rüther, Martin (1)
- Schulz, Martin S. (1)
- Schulze, Thomas G. (1)
- Schwederski, Markus (1)
- Scott, Laura J. (1)
- Scott, Rodney J. (1)
- Sebastian, Martin (1)
- Sedding, Daniel (1)
- Seibel, Tobias (1)
- Sellmann, Timur (1)
- Senner, Fanny (1)
- Serretti, Alessandro (1)
- Shadrin, Alexey (1)
- Shi, Wei (1)
- Shilling, Paul D. (1)
- Sigurdsson, Engilbert (1)
- Silber, Sigmund (1)
- Sindermann, Lisa (1)
- Sirignano, Lea (1)
- Siskind, Dan (1)
- Slaney, Claire (1)
- Sloofman, Laura G. (1)
- Smeland, Olav B. (1)
- Smith, Daniel J. (1)
- Smith, Kevin (1)
- Smoller, Jordan W. (1)
- Sobell, Janet L. (1)
- Soler Artigas, Maria (1)
- Spallotta, Francesco (1)
- Spies, Claudia D. (1)
- Squassina, Alessio (1)
- Stahl, Eli A. (1)
- Stalla, Günter K. (1)
- Stefansson, Hreinn (1)
- Stefansson, Kari (1)
- Stein, Dan J. (1)
- Stein, Frederike (1)
- Steinle, Alexander (1)
- Stordal, Eystein (1)
- Stosnach, Claudia (1)
- Straub, Andreas (1)
- Streit, Fabian (1)
- Struck, Vera (1)
- Su, Mei-Hsin (1)
- Sullivan, Patrick F. (1)
- Sung, Heejong (1)
- Terao, Chikashi (1)
- Terheyden, Patrick (1)
- Tesch, Sebastian (1)
- Tesfaye, Markos (1)
- Tesli, Martin (1)
- Thomas, Niklas (1)
- Thome, Johannes (1)
- Thoms, Kai-Martin (1)
- Thorgeirsson, Thorgeir E. (1)
- Thorp, Jackson G. (1)
- Tognarelli, Sara (1)
- Toma, Claudio (1)
- Tondo, Leonardo (1)
- Tooney, Paul A. (1)
- Torres-Lopez, Lucia V. (1)
- Tsai, Shih-Jen (1)
- Tsermpini, Evangelia Eirini (1)
- Turecki, Gustavo (1)
- Ugolini, Sophie (1)
- Ugurel, Selma (1)
- Ullrich, Evelyn (1)
- Ulrich, Jens (1)
- Utikal, Jochen (1)
- Vaaler, Arne E. (1)
- Vawter, Marquis P. (1)
- Vedder, Helmut (1)
- Velten, Markus (1)
- Venz, John (1)
- Verbuecheln, Raphael (1)
- Vermehren, Johannes (1)
- Vieta, Eduard (1)
- Vincent, John B. (1)
- Vivier, Eric (1)
- Vogl, Thomas J. (1)
- Voran, Anette (1)
- Vreeker, Annabel (1)
- Waldman, Irwin D. (1)
- Walters, James T. R. (1)
- Waltes, Regina (1)
- Walzer, Thierry (1)
- Wang, Xin (1)
- Wappler, Frank (1)
- Wehler, Thomas (1)
- Weichenthal, Michael (1)
- Weickert, Cynthia S. (1)
- Weickert, Thomas W. (1)
- Weigand, Markus A. (1)
- Weil, Sandra (1)
- Weiler, Nina (1)
- Weiß, Christian (1)
- Weiß, Manfred (1)
- Welker, Martin-Walter (1)
- Wenzel, Mike (1)
- Werge, Thomas (1)
- Wessely, Anja (1)
- Whiteman, David C. (1)
- Wiesmann, Thomas (1)
- Wild, Peter Johannes (1)
- Willis, Simon N. (1)
- Winkenbach, Andreas (1)
- Winkenbach, Andreas Thomas (1)
- Winsvold, Bendik S. (1)
- Witt, Stephanie H. (1)
- Wittchen, Hans-Ulrich (1)
- Wolf, Sebastian (1)
- Won, Hong-Hee (1)
- Ye, Robert (1)
- Yel, Ibrahim (1)
- Young, Allan H. (1)
- Yousaf, Afsheen (1)
- Youzouri, Hanan el (1)
- Zandi, Peter P. (1)
- Zeiher, Andreas M. (1)
- Zhdanovich, Yauheniya (1)
- Ziller, Fabian (1)
- Zillich, Lea (1)
- Zippelius, Alfred (1)
- Zwart, John-Anker (1)
- Zöller, Tobias (1)
- van der Veen, Tracey (1)
- Świątkowska, Beata (1)
Document Type
- Article (20)
- Conference Proceeding (1)
- Doctoral Thesis (1)
- Preprint (1)
Has Fulltext
- yes (23)
Is part of the Bibliography
- no (23)
Keywords
- Biosynthetic mesh (2)
- Depression (2)
- Incisional hernia (2)
- ADHD (1)
- ARDS (1)
- Affect (1)
- Alcohol consumption (1)
- Ambulatory Assessment (1)
- Artificial intelligence (1)
- Attention-deficit / hyperactivity disorder (1)
Institute
- Medizin (23) (remove)
Koch, Elena ; Freitag, Christine M. ; Mayer, Jutta ; Medda, Juliane ; Reif, Andreas ; Grimm, Oliver ; Ramos-Quiroga, Josep Antoni ; Palacio Sanchez, Judit ; Asherson, Philip ; Kuntsi, Jonna ; Pawley, Adam D. ; Buitelaar, Jan K. ; Bergsma, Douwe ; Ortega, Francisco B. ; Muntaner-Mas, Adrià ; Reinhard, Iris ; Reichert, Markus ; Giurgiu, Marco ; Ebner-Priemer, Ulrich
Exercise interventions in mental disorders have evidenced a mood-enhancing effect. However, the association between physical activity and affect in everyday life has not been investigated in adult individuals with ADHD, despite being important features of this disorder. As physical activity and affect are dynamic processes in nature, assessing those in everyday life with e-diaries and wearables, has become the gold standard. Thus, we used an mHealth approach to prospectively assess physical activity and affect processes in individuals with ADHD and controls aged 14–45 years. Participants wore accelerometers across a four-day period and reported their affect via e-diaries twelve times daily. We used multilevel models to identify the within-subject effects of physical activity on positive and negative affect. We split our sample into three groups: 1. individuals with ADHD who were predominantly inattentive (n = 48), 2. individuals with ADHD having a combined presentation (i.e., being inattentive and hyperactive; n = 95), and 3. controls (n = 42). Our analyses revealed a significant cross-level interaction (F(2, 135.072)=5.733, p = 0.004) of physical activity and group on positive affect. In details, all groups showed a positive association between physical activity and positive affect. Individuals with a combined presentation significantly showed the steepest slope of physical activity on positive affect (slope_inattentive=0.005, p<0.001; slope_combined=0.009, p<0.001; slope_controls=0.004, p = 0.008). Our analyses on negative affect revealed a negative association only in the individuals with a combined presentation (slope=-0.003; p = 0.001). Whether this specifically pronounced association in individuals being more hyperactive might be a mechanism reinforcing hyperactivity needs to be empirically clarified in future studies.
Bernatz, Simon ; Ackermann, Jörg ; Mandel, Philipp ; Kaltenbach, Benjamin ; Zhdanovich, Yauheniya ; Harter, Patrick Nikolaus ; Döring, Claudia ; Hammerstingl, Renate Maria ; Bodelle, Boris ; Smith, Kevin ; Bucher, Andreas ; Albrecht, Moritz Hans Ernst ; Rosbach, Nicolas ; Basten, Lajos Maximilian ; Yel, Ibrahim ; Wenzel, Mike ; Bankov, Katrin ; Koch, Ina ; Chun, Felix ; Köllermann, Jens ; Wild, Peter Johannes ; Vogl, Thomas J.
Objectives: To analyze the performance of radiological assessment categories and quantitative computational analysis of apparent diffusion coefficient (ADC) maps using variant machine learning algorithms to differentiate clinically significant versus insignificant prostate cancer (PCa). Methods: Retrospectively, 73 patients were included in the study. The patients (mean age, 66.3 ± 7.6 years) were examined with multiparametric MRI (mpMRI) prior to radical prostatectomy (n = 33) or targeted biopsy (n = 40). The index lesion was annotated in MRI ADC and the equivalent histologic slides according to the highest Gleason Grade Group (GrG). Volumes of interest (VOIs) were determined for each lesion and normal-appearing peripheral zone. VOIs were processed by radiomic analysis. For the classification of lesions according to their clinical significance (GrG ≥ 3), principal component (PC) analysis, univariate analysis (UA) with consecutive support vector machines, neural networks, and random forest analysis were performed. Results: PC analysis discriminated between benign and malignant prostate tissue. PC evaluation yielded no stratification of PCa lesions according to their clinical significance, but UA revealed differences in clinical assessment categories and radiomic features. We trained three classification models with fifteen feature subsets. We identified a subset of shape features which improved the diagnostic accuracy of the clinical assessment categories (maximum increase in diagnostic accuracy ΔAUC = + 0.05, p < 0.001) while also identifying combinations of features and models which reduced overall accuracy. Conclusions: The impact of radiomic features to differentiate PCa lesions according to their clinical significance remains controversial. It depends on feature selection and the employed machine learning algorithms. It can result in improvement or reduction of diagnostic performance.
Low platelet count predicts reduced survival in potentially resectable hepatocellular carcinoma
(2022)
Schrecker, Christopher ; Waidmann, Oliver ; Youzouri, Hanan el ; Trojan, Jörg ; Schnitzbauer, Andreas ; Bechstein, Wolf Otto ; Zeuzem, Stefan ; Koch, Christine
The prognostic role of platelet count in hepatocellular carcinoma (HCC) remains unclear, and in fact both thrombocytopenia and thrombocytosis are reported as predictors of unfavourable outcomes. This study aimed to clarify the prognostic value of preoperative platelet count in potentially resectable HCC. We retrospectively reviewed 128 patients who underwent hepatic resection for HCC at a tertiary academic centre (2007–2019). Patient data were modelled by regression analysis, and platelet count was treated as a continuous variable. 89 patients had BCLC 0/A tumours and 39 had BCLC B tumours. Platelet count was higher in patients with larger tumours and lower in patients with higher MELD scores, advanced fibrosis, and portal hypertension (p < 0.001 for all listed variables). After adjusting for BCLC stage and tumour diameter, low platelet count associated with reduced overall survival (hazard ratio 1.25 per 50/nL decrease in platelet count, 95% confidence interval (CI) 1.02–1.53, p = 0.034) and increased perioperative mortality (odds ratio 1.96 per 50/nL decrease in platelet count, 95% CI 1.19–3.53, p = 0.014). Overall, low platelet count correlates with increased liver disease severity, inferior survival, and excess perioperative mortality in resectable HCC. These insights might be applied in clinical practice to better select patients for resection.