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Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small molecule inhibitors, which we call chemogenomic sets, that are designed to inhibit the catalytic function of almost half the human protein kinases. In this manuscript we share our progress towards generation of a comprehensive kinase chemogenomic set (KCGS), release kinome profiling data of a large inhibitor set (Published Kinase Inhibitor Set 2 (PKIS2)), and outline a process through which the community can openly collaborate to create a KCGS that probes the full complement of human protein kinases.
The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification
(2019)
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS) is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.
The status of endemic liverworts in the Western Ghats ‘one of the major Hot spots’ of plant biodiversity have been discussed in the present paper. The study is based on the evaluation of type and authentic specimens available in Lucknow University Hepatic Herbarium (LWU) as well as those in several international herbaria including NICH, NY, JE, FH, G and excicatae of the world and published data. An overall assessment and evaluation revealed the presence of a total of 54 liverworts endemic to Western Ghats in India. The paper also discusses those species which were earlier known as endemic to the area but now show an extended range of distribution elsewhere and also the species earlier introduced from Western Ghats but now changed their status.
Impact parameter sensitive study of inner-shell atomic processes in Xe54+, Xe52+ → Xe collisions
(2020)
In this work, we present a pilot experiment in the experimental storage ring (ESR) at GSI devoted to impact parameter sensitive studies of inner shell atomic processes for bare and He-like xenon ions (Xe54+, Xe52+) colliding with neutral xenon gas atoms. The projectile and target x-rays have been measured at different observation angles for all impact parameters as well as for the impact parameter range of ∼35 - 70 fm.
The Indian species of the genera Orionis Shaw and Stenothremma Shaw (Braconidae, Euphorinae) are reviewed. Both genera are reported for the first time from India. Three new species, Orionis shillongensis Gupta, van Achterberg & Pattar sp. nov. from north-eastern India (Meghalaya), O. femorator Gupta, van Achterberg & Pattar sp. nov. from southern India (Karnataka and Tamil Nadu) and Stenothremma flavator Gupta & van Achterberg sp. nov. from southern India (Karnataka) are illustrated and described. A key to the Old World species of Orionis Shaw is provided.