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Institute
Faraone, Stephen V. ; Banaschewski, Tobias ; Coghill, David ; Zheng, Yi ; Biederman, Joseph ; Bellgrove, Mark A. ; Newcorn, Jeffrey H. ; Gignac, Martin ; Al Saud, Nouf M. ; Manor, Iris ; Rohde, Luis Augusto ; Yang, Li ; Cortese, Samuele ; Almagor, Doron ; Stein, Mark A. ; Albatti, Turki H. ; Aljoudi, Haya F. ; Alqahtani, Mohammed M.J. ; Asherson, Philip ; Atwoli, Lukoye ; Bölte, Sven ; Buitelaar, Jan K. ; Crunelle, Cleo L. ; Daley, David ; Dalsgaard, Søren ; Döpfner, Manfred ; Espinet, Stacey ; Fitzgerald, Michael ; Franke, Barbara ; Gerlach, Manfred ; Haavik, Jan ; Hartman, Catharina A. ; Hartung, Cynthia M. ; Hinshaw, Stephen P. ; Hoekstra, Pieter J. ; Hollis, Chris ; Kollins, Scott H. ; Kooij, Johanna Jacoba Sandra ; Kuntsi, Jonna ; Larsson, Henrik ; Li, Tingyu ; Liu, Jing ; Merzon, Eugene ; Mattingly, Gregory ; Mattos, Paulo ; McCarthy, Suzanne ; Mikami, Amori Yee ; Molina, Brooke S.G. ; Nigg, Joel T. ; Purper-Ouakil, Diane ; Omigbodun, Olayinka O. ; Polanczyk, Guilherme V. ; Pollak, Yehuda ; Poulton, Alison S. ; Reif, Andreas ; Rajkumar, Ravi Philip ; Rubia, Katya ; Reding, Andrew ; Rucklidge, Julia ; Romanos, Marcel ; Ramos-Quiroga, J. Antoni ; Schellekens, Arnt ; Scheres, Anouk ; Schoeman, Renata ; Schweitzer, Julie B. ; Shah, Henal ; Solanto, Mary V. ; Sonuga-Barke, Edmund ; Soutullo, César ; Steinhausen, Hans-Christoph ; Swanson, James M. ; Thapar, Anita ; Tripp, Gail ; Glind, Geurt van de ; Brink, Wim van den ; Oord, Saskia van der ; Venter, Andre ; Vitiello, Benedetto ; Walitza, Susanne ; Wang, Yufeng
Background: Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base. Methods: We reviewed studies with more than 2000 participants or meta-analyses from five or more studies or 2000 or more participants. We excluded meta-analyses that did not assess publication bias, except for meta-analyses of prevalence. For network meta-analyses we required comparison adjusted funnel plots. We excluded treatment studies with waiting-list or treatment as usual controls. From this literature, we extracted evidence-based assertions about the disorder. Results: We generated 208 empirically supported statements about ADHD. The status of the included statements as empirically supported is approved by 80 authors from 27 countries and 6 continents. The contents of the manuscript are endorsed by 366 people who have read this document and agree with its contents. Conclusions: Many findings in ADHD are supported by meta-analysis. These allow for firm statements about the nature, course, outcome causes, and treatments for disorders that are useful for reducing misconceptions and stigma.
Kiltz, Uta ; Buschhorn-Milberger, Verena ; Albrecht, K. ; Lakomek, Heinz-Jürgen ; Lorenz, Hanns-Martin ; Rudwaleit, M. ; Schneider, M. ; Schulze-Koops, Hendrik ; Baraliakos, Xenofon ; Behrens, Frank ; Brandt-Jürgens, Jan ; Haibel, H. ; Hammel, L. ; Karberg, K. ; Kellner, H. ; Krause, Daniela Sandra ; Lange, U. ; Märker-Herrmann, E. ; Poddubnyy, Denis ; Sieper, J. ; Syrbe, Uta ; Braun, J.
Qualitätsstandards (QS) sind messbare Konstrukte, die helfen sollen, Versorgungslücken quantitativ zu erfassen, um langfristig die Versorgungsqualität zu verbessern. Die Assessment of SpondyloArthritis International Society (ASAS) hat kürzlich erstmals internationale QS für das Management von Patient*innen mit axialer Spondyloarthritis (axSpA) konsentiert und veröffentlicht. Die Deutsche Gesellschaft für Rheumatologie (DGRh) hat daraufhin beschlossen, diese Standards durch eine Gruppe von Expert*innen aus unterschiedlichen Versorgungsbereichen zu übersetzen, zu prüfen und ggf. zu übernehmen. Vor diesem Hintergrund wurden erstmals nationale QS für das Management von Patient*innen mit axSpA für Deutschland entwickelt. Hierbei wurde v. a. auf Machbarkeit und Praxisrelevanz geachtet. Letztlich wurden 9 QS definiert, mit denen die Qualität der Versorgung in Deutschland gemessen und verbessert werden kann bzw. soll.
Peter, Alina ; Stauch, Benjamin J. ; Shapcott, Katharine A. ; Kouroupaki, Kleopatra ; Schmiedt, Joscha Tapani ; Klein, Liane ; Klon-Lipok, Johanna ; Dowdall, Jarrod Robert ; Schölvinck, Marieke L. ; Vinck, Martin ; Singer, Wolf ; Schmid, Michael Christoph ; Fries, Pascal
When a visual stimulus is repeated, average neuronal responses typically decrease, yet they might maintain or even increase their impact through increased synchronization. Previous work has found that many repetitions of a grating lead to increasing gamma-band synchronization. Here, we show in awake macaque area V1 that both repetition-related reductions in firing rate and increases in gamma are specific to the repeated stimulus. These effects show some persistence on the timescale of minutes. Gamma increases are specific to the presented stimulus location. Further, repetition effects on gamma and on firing rates generalize to images of natural objects. These findings support the notion that gamma-band synchronization subserves the adaptive processing of repeated stimulus encounters.